CN1330366C - Piles ointment and its preparation method - Google Patents
Piles ointment and its preparation method Download PDFInfo
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- CN1330366C CN1330366C CNB2004100676307A CN200410067630A CN1330366C CN 1330366 C CN1330366 C CN 1330366C CN B2004100676307 A CNB2004100676307 A CN B2004100676307A CN 200410067630 A CN200410067630 A CN 200410067630A CN 1330366 C CN1330366 C CN 1330366C
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Abstract
The present invention discloses a piles treating ointment and a preparation method thereof. The preparation method comprises the following steps: after adding specified proportion of coarse powder of original medicines such as rhubarb, pagodatree flower, largetrifoliolious bugbane rhizome, turmeric root tuber, bezoar, raw licorice to alcohol with the concentration of 70% for immersion for 48 hours, filtering the coarse powder at the speed of 3 ml/min; collecting percolating liquid; continuing to percolate the percolating liquid until the percolating liquid is almost slight yellow; collecting the last percolating liquid, evaporating the last percolating liquid into a thick ointment at the temperature of 50DEGC; adding the primary percolating liquid; mixing the primary percolating liquid and the last percolating liquid; adding ethanol with the concentration of 70% for dilution; making the mixture stand for 5 days; after filtering the mixture, adding borneol, musk and pearl powder to the mixture to make fluidextract; adding substrates to the fluidextract to obtain the piles treating ointment of the present invention. The piles treating ointment can improve the cure rate of patients having piles to larger extent and lower side effects during medicine treatment.
Description
Technical field
The present invention relates to a kind of ZHICHUANG GAO and preparation method thereof, particularly a kind of is the ZHICHUANG GAO of feedstock production by Chinese crude drug.
Background technology
Hemorrhoid are the modal anorectal diseases of China, and its sickness rate is up to 87.25%.Because hemorrhoid bring inconvenience and huge misery for patient's work, life, therefore, physicians are exploring the treatment to hemorrhoid always for these years.Up to the present, though existing several different methods and means, the result of treatment makes us satisfied fully.
At present, the definite pathogenesis about hemorrhoid is unclear fully yet.Thinking every can make limited, the intrinsic pressure increase of hemorrhoidal plexus backflow, wall of vein attenuation all help the generation of internal hemorrhoid, and propose multiple hypothesis in the past.1975, the anus pad slip theory that Thomson proposes had deep understanding to the cause of disease, the pathogenesis of hemorrhoid.He at first proposes hemorrhoid is normal anatomical structures that everybody all has, and is the lip shape wart of rectum lower end or the pathologic hypertrophy of anus pad.This new theory receives the very big concern that anorectal disease is learned the expert, also makes the treatment idea that change has taken place.Now, people recognize that progressively the treatment of hemorrhoid should be based on non-operative treatment, and the emphasis of treatment is not at blood stasis itself, but eliminate or relief of symptoms.
In view of hemorrhoid Therapeutic Principle's renewal, and medicine in the past still exists many drawbacks, and it is extremely necessary therefore researching and developing novel medicine for external use.At present, about 50 kinds of domestic and international various ZHICHUANG GAO (bolt) mostly are the Western medicine or the combination of Chinese and Western medicine mix preparation based on Western medicine, only are used for I, II phase internal hemorrhoid, act on of short duration, curative effect is not good enough.
Summary of the invention
Technical problem to be solved by this invention provides a kind of ZHICHUANG GAO and preparation method thereof, and it can improve the cure rate of hemorrhoid patients more, reduces the side effect in the Drug therapy process.
For solving the problems of the technologies described above, the present invention by the following technical solutions: a kind of ZHICHUANG GAO is characterized in that making the raw materials of effective components medicine and consists of by weight:
Radix Et Rhizoma Rhei 800 ~ 1000g
Flos Sophorae 300 ~ 500g
Rhizoma Cimicifugae 300 ~ 500g
Rhizoma Curcumae Longae 50 ~ 150g
Margarita 50 ~ 100g
Calculus Bovis 10 ~ 30g
Borneolum Syntheticum 10 ~ 20g
Moschus 1g
Radix Glycyrrhizae 150 ~ 250g
Above-mentioned raw materials medicine best group by weight becomes:
Radix Et Rhizoma Rhei 1000g
Flos Sophorae 500g
Rhizoma Cimicifugae 500g
Rhizoma Curcumae Longae 150g
Margarita 100g
Calculus Bovis 30g
Borneolum Syntheticum 20g
Moschus 1g
Radix Glycyrrhizae 250g
The preparation method of ZHICHUANG GAO of the present invention; comprise Radix Et Rhizoma Rhei with the regulation proportioning; Flos Sophorae; Rhizoma Cimicifugae; Rhizoma Curcumae Longae; Calculus Bovis; the former medicine coarse powder of Radix Glycyrrhizae is in former medicine gross weight (g): the ratio of ethanol (ml)=1: 6 added 70% alcohol dipping after 48 hours; filter with 3ml/min speed; collect first percolate by 85% milliliter of number of former medicine gross weight quantity; device is preserved in addition; continue diafiltration; till the nearly little Huang of percolate; collect continuous percolate; be evaporated to the thick paste shape at 50 ℃; add percolate just; mix, add 70% ethanol dilution, left standstill 5 days; add Borneolum Syntheticum after the filtration; Moschus; Margarita powder becomes fluid extract, and above-mentioned fluid extract is mixed by white vaseline; stearic acid; glycerol; the substrate that sodium lauryl sulphate is formed is ZHICHUANG GAO of the present invention.
In the ZHICHUANG GAO raw material of the present invention, Radix Et Rhizoma Rhei has the intestinal stasis relieving dehumidifying, invigorates blood circulation, stops blooding, the effect of heat-clearing and toxic substances removing; Flos Sophorae has heat clearing away, removing heat from blood, hemostatic function, can improve capillary permeability; Margarita endemic element angle shell globulin can be restrained wound, promotes healing; Rhizoma Cimicifugae, Rhizoma Curcumae Longae, Borneolum Syntheticum and Radix Et Rhizoma Rhei share, and have elevate a turnable ladder yang-energy, promoting the circulation of QI to relieve pain, heat-clearing toxin-expelling functions.The curative effect of ZHICHUANG GAO of the present invention is verified through animal experiment and clinical use.
Further specify the present invention below by embodiment.
The specific embodiment
Embodiment 1
The preparation of ZHICHUANG GAO of the present invention: with Radix Et Rhizoma Rhei 1000g; Flos Sophorae 500g; Rhizoma Cimicifugae 500g; Rhizoma Curcumae Longae 150g; Calculus Bovis 30g; the coarse powder of Radix Glycyrrhizae 250g is in former medicine gross weight (g): ethanol (ml)=ratio of 1: 6 adds 70% ethanol of 14580ml; flood after 48 hours; filter with 3ml/min speed; collect percolate 2065ml (being 85% milliliter of number of former medicine gross weight quantity) just; device is preserved in addition; continue diafiltration; till the nearly little Huang of percolate; collect continuous percolate; be evaporated to the thick paste shape at 50 ℃; add percolate just; mix, add 70% ethanol dilution, left standstill 5 days; add Borneolum Syntheticum 20g after the filtration; Moschus 1g; Margarita powder 100g becomes fluid extract, and above-mentioned fluid extract is mixed by white vaseline 100g; stearic acid 100g; glycerol 50g; the substrate that sodium lauryl sulphate 4g forms is ZHICHUANG GAO of the present invention.
Embodiment 2
Experiment material and animal: select Kunming kind white mice for use, the male and female dual-purpose, mice body weight 18～22g, dosage group in the ZHICHUANG GAO of the present invention, high dose group (patent medicine 0.5 times), low dose group (dosage is 0.25 times of high dose group patent medicine) and MAYINGLONG MUSK HEMORRHOID UNGUENTUM (Wuhan Mayinglong Pharmaceutical Group Corp., Ltd's production) are observed
Get 50 of male white mouses, random packet.Evenly be applied to two sides, ear front and back, a mice left side with dimethylbenzene 0.05ml and cause inflammation, 0.5h after, each experimental mice causes and evenly is coated with ZHICHUANG GAO of the present invention or MAYINGLONG MUSK HEMORRHOID UNGUENTUM on the scorching auricle respectively, control group mice is coated with excipient, every 4h, the mice dislocation of cervical vertebra is caused death, cut two ears along the auricle baseline, lay an auricle at same position respectively with diameter 8mm card punch, on analytical balance, weigh, ask poor (Δ mg) reflection swelling degree of two auricle weight, the result is as shown in table 1, and the swelling degree of the height of ZHICHUANG GAO group of the present invention, middle dosage group auricle all is lower than other groups.
Table 1 ZHICHUANG GAO xylol of the present invention causes the influence of mice auricular concha swelling
| Group | Number of animals (n) | Dosage (mg/ only) | Swelling degree (mg) |
| Matched group | 10 | 10 | 10.19±1.19 |
| The MAYINGLONG MUSK HEMORRHOID UNGUENTUM group | 10 | 10 | 7.77±0.47 △ |
| ZHICHUANG GAO group of the present invention (high dose) | 10 | 10 | 6.62±0.36 △▲※ |
| ZHICHUANG GAO group of the present invention (middle dosage) | 10 | 10 | 6.84±0.82 △▲※ |
| ZHICHUANG GAO group of the present invention (low dosage) | 10 | 10 | 7.93±0.65 |
| The F value | 35.17 | ||
| The P value | ＜0.001 |
Compare Δ p＜0.01 with matched group, with MAYINGLONG MUSK HEMORRHOID UNGUENTUM group comparison ▲ p＜0.01
Embodiment 3
Get 75 of white mice, divide excipient matched group, the high, medium and low dosage group of ZHICHUANG GAO of the present invention, MAYINGLONG MUSK HEMORRHOID UNGUENTUM group at random, after intraperitoneal injection is subjected to reagent 1h, blue every the 0.1ml of tail vein injection 0.5%Evans, every 0.2ml of 0.6% acetic acid of intraperitoneal injection immediately, mice is put to death in dislocation of cervical vertebra behind the 30min, with 5ml distilled water flushing abdominal cavity for several times, draw peritoneal fluid, the centrifugal 5min of 1000r/min, get supernatant, in 590nm place colorimetric, read optical density (0D) value with 721 type spectrophotometers.The result is as shown in table 2, and the OD value of ZHICHUANG GAO height of the present invention, middle dosage group is starkly lower than other groups, shows that ZHICHUANG GAO of the present invention has the effect of significant inflammation limitation.
Table 2 ZHICHUANG GAO of the present invention is to putting the influence of abdominal cavity capillary permeability for a short time
Compare Δ p＜0.01 with matched group,, compare ※ p＜0.01 with the low group of the present invention with horse group comparison ▲ p＜0.01
Embodiment 4
ZHICHUANG GAO of the present invention is through clinical verification, and the result is as follows:
Observe in JIUYUE, 2000 between January calendar year 2001, in the patient that outpatient service is accepted for medical treatment, select 150 examples.Man's 76 examples, women 74 examples, 7～84 years old age, mean age (42.1 ± 13.6).Diagnostic criteria is by the traditional Chinese medical science anorectal section disease diagnostic criteria of nineteen ninety-five State Administration of Traditional Chinese Medicine's issue, selection have have blood in stool, pain, deviate from, hemorrhoid and the anal fissure patient of six big symptoms such as edema, bob expand, pruritus, eliminating intentionally, the serious disease person of internal organs such as liver, kidney.Use CASIO fx-4500p computer to be divided into two groups at random, ZHICHUANG GAO group 83 examples of the present invention, MAYINGLONG MUSK HEMORRHOID UNGUENTUM group 67 examples.Adopt double blind method, medicine adopts the 10g dress aluminum hull packing of unified appearance, is respectively charged into ZHICHUANG GAO of the present invention and MAYINGLONG MUSK HEMORRHOID UNGUENTUM.Using method is that unguentum is coated outside the anal, and 2 times on the one, each consumption 1～2g wraps up with dressing as far as possible.Work out special-purpose case history, the next day observe the clinical manifestation of each symptom, the observation period is limited to seven days.The viewing duration other drug of stopping using.The traditional Chinese medical science anorectal section disease diagnosis criterion of therapeutical effect that criterion of therapeutical effect is implemented by the issue of State Administration of Traditional Chinese Medicine nineteen ninety-five is divided three grades: transference cure is recovery from illness, and doing well,improving is for taking a turn for the better, symptom do not have obviously change into invalid.Date processing adopts Ridit to analyze and u-test, and curative day is relatively checked with t.
1, two group six big primary symptom curative effect is relatively by analyzing us as can be seen, and ZHICHUANG GAO treatment of the present invention is had blood in stool, the effect of pain obviously is better than MAYINGLONG MUSK HEMORRHOID UNGUENTUM (p＜0.05), has significant difference, sees Table 3.
Table 3 liang group six big primary symptom curative effects relatively
| Symptom | Group | n | Recovery from illness | Effectively | Invalid | R | u | P |
| Have blood in stool | ZHICHUANG GAO MAYINGLONG MUSK HEMORRHOID UNGUENTUM of the present invention | 47 42 | 37 21 | 9 18 | 1 3 | 0.5689 0.4230 | 2.84 | ＜0.01 |
| Pain | ZHICHUANG GAO MAYINGLONG MUSK HEMORRHOID UNGUENTUM of the present invention | 48 32 | 34 14 | 13 17 | 1 1 | 0.5536 0.4195 | 2.37 | ＜0.05 |
| Deviate from | ZHICHUANG GAO MAYINGLONG MUSK HEMORRHOID UNGUENTUM of the present invention | 19 21 | 3 2 | 11 11 | 5 8 | 0.5382 0.4655 | 0.88 | ＞0.05 |
| Edema | ZHICHUANG GAO MAYINGLONG MUSK HEMORRHOID UNGUENTUM of the present invention | 15 11 | 8 5 | 6 5 | 1 1 | 0.5179 0.4755 | 0.41 | ＞0.05 |
| Weigh down and expand | ZHICHUANG GAO MAYINGLONG MUSK HEMORRHOID UNGUENTUM of the present invention | 22 16 | 7 2 | 13 10 | 2 4 | 0.5598 0.4178 | 1.69 | ＞0.05 |
| Pruritus | ZHICHUANG GAO MAYINGLONG MUSK HEMORRHOID UNGUENTUM of the present invention | 13 10 | 3 3 | 8 5 | 2 2 | 0.4950 0.5065 | 0.01 | ＞0.05 |
2, the comparison of two groups of curative days, two group six big primary symptom recovery from illness natural law relatively sees Table 4.
Table 4 liang group six big primary symptom recovery from illness natural law are (unit: the sky) relatively
2, two groups of primary symptom total effectses of the comparison of two groups of patient's primary symptoms relatively see Table 5.
Table 5 liang group primary symptom total effects relatively
| Group | The primary symptom sum | Recovery from illness | Effectively | Invalid | R | u | p | |||
| The example number | ％ | The example number | ％ | The example number | ％ | |||||
| ZHICHUANG GAO MAYINGLONG MUSK HEMORRHOID UNGUENTUM of the present invention | 164 132 | 92 47 | 56.09 35.61 | 60 66 | 36.59 50.00 | 12 19 | 7.32 14.39 | 0.5493 0.4388 | 3.6 1 | ＜0.01 |
3, two groups of patient treatment results relatively cure 66 examples in the Jin Shi ZHICHUANG GAO treatment group, 15 examples that take a turn for the better, and invalid 2 examples, its cure rate is 79.5%, total effective rate is 97.6%; And cure 38 examples in the MAYINGLONG MUSK HEMORRHOID UNGUENTUM group, and 21 examples that take a turn for the better, its cure rate is 56.7%, total effective rate is 88.1%.Two groups cure rate is compared the former apparently higher than the latter (p＜0.05), the results are shown in Table 6.
Table 6 liang group patient's therapeutic outcome (unit: routine number)
| n | Cure | Take a turn for the better | Invalid | Cure rate | Total effective rate | |
| MAYINGLONG MUSK HEMORRHOID UNGUENTUM | 67 | 38 | 21 | 8 | 56.7％ | 88.1％ |
| ZHICHUANG GAO of the present invention | 83 | 66 | 15 | 2 | 79.5％ ※ | 97.6％ |
Claims (3)
1, a kind of ZHICHUANG GAO is characterized in that making the raw materials of effective components medicine and consists of by weight:
Radix Et Rhizoma Rhei 800 ~ 1000g
Flos Sophorae 300 ~ 500g
Rhizoma Cimicifugae 300 ~ 500g
Rhizoma Curcumae Longae 50 ~ 150g
Margarita 50 ~ 100g
Calculus Bovis 10 ~ 30g
Borneolum Syntheticum 10 ~ 20g
Moschus 1g
Radix Glycyrrhizae 150 ~ 250g.
2,, it is characterized in that making the raw materials of effective components medicine and consist of by weight according to the described ZHICHUANG GAO of claim 1:
Radix Et Rhizoma Rhei 1000g
Flos Sophorae 500g
Rhizoma Cimicifugae 500g
Rhizoma Curcumae Longae 150g
Margarita 100g
Calculus Bovis 30g
Borneolum Syntheticum 20g
Moschus 1g
Radix Glycyrrhizae 250g.
3; preparation method according to the described ZHICHUANG GAO of claim 1; comprise Radix Et Rhizoma Rhei with the regulation proportioning; Flos Sophorae; Rhizoma Cimicifugae; Rhizoma Curcumae Longae; Calculus Bovis; the former medicine coarse powder of Radix Glycyrrhizae is in former medicine gross weight (g): the ratio of ethanol (ml)=1: 6 added 70% alcohol dipping after 48 hours; filter with 3ml/min speed; collect first percolate by 85% milliliter of number of former medicine gross weight quantity; device is preserved in addition; continue diafiltration; till the nearly little Huang of percolate; collect continuous percolate; be evaporated to the thick paste shape at 50 ℃; add percolate just; mix, add 70% ethanol dilution, left standstill 5 days; add Borneolum Syntheticum after the filtration; Moschus; Margarita powder becomes fluid extract, and above-mentioned fluid extract is mixed by white vaseline; stearic acid; glycerol; the substrate that sodium lauryl sulphate is formed is ZHICHUANG GAO of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100676307A CN1330366C (en) | 2004-10-29 | 2004-10-29 | Piles ointment and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100676307A CN1330366C (en) | 2004-10-29 | 2004-10-29 | Piles ointment and its preparation method |
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| CN1765415A CN1765415A (en) | 2006-05-03 |
| CN1330366C true CN1330366C (en) | 2007-08-08 |
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| CNB2004100676307A Expired - Fee Related CN1330366C (en) | 2004-10-29 | 2004-10-29 | Piles ointment and its preparation method |
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| CN105148024B (en) * | 2015-10-09 | 2018-11-13 | 刘桂沅 | Chemicals curing piles ointment machin manufacture craft |
| CN106176914A (en) * | 2016-07-08 | 2016-12-07 | 刘福坤 | A kind of method of Traditional Chinese Medicine for external application treatment hemorrhoid |
| CN106177564A (en) * | 2016-08-12 | 2016-12-07 | 林海燕 | A kind of pharmaceutical composition treating hemorrhoid and preparation method thereof |
| CN110123976A (en) * | 2019-06-28 | 2019-08-16 | 中国医学科学院药用植物研究所云南分所 | It is a kind of to treat hemorrhoid dai medicine smearing cream and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1247075A (en) * | 1998-09-09 | 2000-03-15 | 王奉炳 | Chinese patent medicine for treating piles |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1247075A (en) * | 1998-09-09 | 2000-03-15 | 王奉炳 | Chinese patent medicine for treating piles |
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