CN104606465A - Medicine for treating acute pharyngitis and preparation method for medicine - Google Patents
Medicine for treating acute pharyngitis and preparation method for medicine Download PDFInfo
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- CN104606465A CN104606465A CN201510098149.2A CN201510098149A CN104606465A CN 104606465 A CN104606465 A CN 104606465A CN 201510098149 A CN201510098149 A CN 201510098149A CN 104606465 A CN104606465 A CN 104606465A
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Abstract
The invention belongs to the technical field of medicines and particularly relates to a medicine for treating acute pharyngitis and a preparation method for the medicine. The provided medicine for treating the acute pharyngitis mainly comprises the following components: 7-9 parts of fresh rehmannia, 9-11 parts of folium sennae, 5-7 parts of moutan bark, 9-11 parts of rhizoma anemarrhenae, 6-10 parts of cicada slough, 3-5 parts of burdock, 7-9 parts of schizonepeta and 3-5 parts of licorice root. The medicine has a very good curative effect in an aspect of treating the acute pharyngitis, is low in side effect, and has a remarkable clinical promotion value.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of medicine for the treatment of acute pharyngitis and preparation method thereof.
Background technology
Acute pharyngitis is otorhinolaryngologic commonly encountered diseases, frequently-occurring disease, is pharynx mucosa and under involving mucosa and adenoid acute inflammation, being often secondary to acute tonsillitis or acute rhinitis, also can occurring separately, is a part for upper respiratory tract infection.Also be often the topical manifestations of general disease or the prodrome for acute infectious disease.Primary disease is common in the autumn and winter and Winter-Spring replaces season.The treatment of acute pharyngitis mainly contains Chinese traditional treatment and western medical treatment two kinds, and doctor trained in Western medicine is based on antiviral, and the traditional Chinese medical science is determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs then.The category that acute pharyngitis belongs to " acute inflammation of the throat " is said from traditional Chinese medical science medical angle, in conjunction with modern Chinese medicine theory of development, from improving curative effect of medication, reducing the angle of side effect, through carrying out to Chinese medicine the Chinese medicine preparation that screening is extracted and/or compatibility is obtained, side effect is little, instant effect, and curative effect is generally obvious is better than Western medicine, and side effect is little, clinic is studied further and is promoted.
Summary of the invention
The invention provides a kind of medicine for the treatment of acute pharyngitis, this curative effect of medication is good, and side effect is little, is obtained by following crude drug: Radix Rehmanniae, Folium Sennae, Cortex Moutan, the Rhizoma Anemarrhenae, Periostracum Cicadae, Fructus Arctii, Herba Schizonepetae, Radix Glycyrrhizae.
Described Radix Rehmanniae, GUIXIN, liver, kidney channel.Radix Rehmanniae: clearing away heat and promoting production of body fluid, removing heat from blood, hemostasis.For consumption of YIN caused by febrile disease, crimson tongue excessive thirst, sends out speckle dermexanthesis, spits blood, epistaxis, laryngopharynx swelling and pain.Radix Rehmanniae: clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid.For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis sends out speckle dermexanthesis.
Folium Sennae, sweet, bitter, cold.Return large intestine channel.The row that purges heat is stagnant, relieving constipation, diuretic.Stagnate for accumulation of heat, constipation is suffered from abdominal pain, edema distension.
Cortex Moutan, bitter, pungent, be slightly cold.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.
The Rhizoma Anemarrhenae, bitter, sweet, cold.Return lung, stomach, kidney channel.Clearing away heat-fire, promotes the production of body fluid and moisturizes.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.
Periostracum Cicadae, sweet, cold.Return lung, Liver Channel.Loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.
Fructus Arctii is pungent, bitter, cold.Attach to the lung and stomach meridians.Dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps erysipelas, carbuncle sore tumefacting virus
Herba Schizonepetae, pungent, tepor.Return lung, Liver Channel.Induce sweat loose wind, rash.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.
Radix Glycyrrhizae, sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Medicine of the present invention on Chinese medicinal components is selected with clearing heat for detumescence sore-throat relieving for main standard, the parts by weight of the present invention to above-mentioned all taste Chinese medicine carry out preferably, preferred condition be after drug matching uses medicine to the enhancing of acute pharyngitis therapeutic effect.Preferably, medicine of the present invention is obtained by the crude drug of following weight portion: Radix Rehmanniae 7-9 part, Folium Sennae 9-11 part, Cortex Moutan 5-7 part, Rhizoma Anemarrhenae 9-11 part, Periostracum Cicadae 6-10 part, Fructus Arctii 3-5 part, Herba Schizonepetae 7-9 part, Radix Glycyrrhizae 3-5 part.As a most preferred embodiment of the present invention, medicine of the present invention is obtained by the crude drug of following weight portion: Radix Rehmanniae 8 parts, Folium Sennae 10 parts, Cortex Moutan 6 parts, the Rhizoma Anemarrhenae 10 parts, Periostracum Cicadae 8 parts, Fructus Arctii 4 parts, Herba Schizonepetae 8 parts, 4 parts, Radix Glycyrrhizae.
Radix Rehmanniae described in we, Cortex Moutan clearing away heat and cooling blood, Folium Sennae, Rhizoma Anemarrhenae clearing away heat and promoting production of body fluid, Periostracum Cicadae, Fructus Arctii, Herba Schizonepetae wind-dispelling heat-dissipating, relieving sore throat and diminishing swelling, Radix Glycyrrhizae relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.The same use of all medicine compatibilities, play heat-clearing and toxic substances removing altogether, promote the production of body fluid moisturize, effect of removing heat from blood sore-throat relieving.
Present invention also offers a kind of preparation method of medicine described above, it comprises following step: each crude drug getting recipe quantity is ground into coarse powder respectively, decoct with water twice, add the water of medical material gross weight 5-7 times amount for the first time, decocting time is 2h, second time adds the water of medical material gross weight 4-5 times amount, decocting time is 2h, merge decoction liquor, filter, after filtrate cools, adding ethanol to concentration is 50-70%, leave standstill 24 hours, reflux, extract, three times, return time is 2h, filter, filtrate recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, add pharmaceutically acceptable adjuvant again, mix homogeneously, conveniently technique is prepared into each dosage form.Preferably, medicine of the present invention conveniently preparation technology is prepared into oral formulations, can be oral liquid, powder, granule, buccal tablet, electuary or capsule.
The present invention also asks the purposes in preparation treatment acute pharyngitis medicine, the purposes especially in preparation treatment lung excess of the stomach pattern of fever acute pharyngitis medicine.The results of pharmacodynamic test display of specific embodiment 7, compare with model group, pharmaceutical composition of the present invention three groups and positive controls all significantly can reduce the ear swelling value (P < 0.01) of dimethylbenzene induced mice, show that pharmaceutical composition of the present invention has the effect of the mice ear significantly suppressing dimethylbenzene induction, show that medicament composing prescription compatibility of the present invention is reasonable, antiphlogistic effects is remarkable.Under same experiment condition, compared with positive controls, the present invention II group, III group, the present invention I group reduces the effect more remarkable (P < 0.05) of ear swelling value, and it is more reasonable that this also reflects the present invention's I group of prescription, and antiphlogistic effects is more remarkable.In the clinical observation of specific embodiment 8, patient all completes clinical observation.Efficacy result statistics is as follows: treatment group clinical recovery 16 example (40%), effective 21 examples (52.5%), effective 3 examples (7.5%), invalid 0 example, total effective rate 100%, and clinical effectiveness is remarkable; Matched group clinical recovery 9 example (22.5%), effective 10 examples (25%), effective 9 examples (22.5%), invalid 12 examples (30%), total effective rate 70%.Two groups of total effective rates compare, and have significant difference, treatment group is significantly better than matched group, illustrate that medicine of the present invention is the active drug for the treatment of acute pharyngitis.In treatment group patient treatment procedure, vital sign steadily and without serious adverse reactions such as allergy, show that the clinical application of we is safely and effectively, is worth research further.
In sum, pharmaceutical composition of the present invention, in treatment acute pharyngitis, compared with prior art, has prescription and more simplifies, dosage is lower, preparation technology simply easily operation waits clear superiority, simultaneously clinical drug instant effect of the present invention and lasting, and cure rate is high, evident in efficacy, have no side effect, illustrate that medicine of the present invention is the active drug for the treatment of acute pharyngitis particularly lung excess of the stomach pattern of fever acute pharyngitis, be applicable to clinical application.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
EXAMPLE l
Each raw material is taken: Radix Rehmanniae 8 parts, Folium Sennae 10 parts, Cortex Moutan 6 parts, the Rhizoma Anemarrhenae 10 parts, Periostracum Cicadae 8 parts, Fructus Arctii 4 parts, Herba Schizonepetae 8 parts, 4 parts, Radix Glycyrrhizae by following weight portion.
Preparation method: each crude drug getting recipe quantity is ground into coarse powder respectively, decoct with water twice, add the water of medical material gross weight 6 times amount for the first time, decocting time is 2h, and second time adds the water of medical material gross weight 4 times amount, decocting time is 2h, merge decoction liquor, filter, after filtrate cools, adding ethanol to concentration is 60%, leave standstill 24 hours, reflux, extract, three times, return time is 2h, filter, filtrate recycling ethanol, is concentrated into extractum, and extract dry becomes fine powder, add pharmaceutically acceptable adjuvant again, mix homogeneously; Conveniently preparation technology is prepared into capsule, and every capsules is containing crude drug 0.3g.
Embodiment 2
Each raw material is taken: Radix Rehmanniae 8 parts, Folium Sennae 10 parts, Cortex Moutan 6 parts, the Rhizoma Anemarrhenae 10 parts, Periostracum Cicadae 8 parts, Fructus Arctii 4 parts, Herba Schizonepetae 8 parts, 4 parts, Radix Glycyrrhizae by following weight portion.
Preparation method: each crude drug getting recipe quantity is ground into coarse powder respectively, decoct with water twice, add the water of medical material gross weight 6 times amount for the first time, decocting time is 2h, and second time adds the water of medical material gross weight 4 times amount, decocting time is 2h, merge decoction liquor, filter, after filtrate cools, adding ethanol to concentration is 60%, leave standstill 24 hours, reflux, extract, three times, return time is 2h, filter, filtrate recycling ethanol, is concentrated into extractum, and extract dry becomes fine powder, add pharmaceutically acceptable adjuvant again, mix homogeneously; Conveniently preparation technology is prepared into granule, and every bag of granule is containing crude drug 3g.
Embodiment 3
Each raw material is taken: Radix Rehmanniae 8 parts, Folium Sennae 10 parts, Cortex Moutan 6 parts, the Rhizoma Anemarrhenae 10 parts, Periostracum Cicadae 8 parts, Fructus Arctii 4 parts, Herba Schizonepetae 8 parts, 4 parts, Radix Glycyrrhizae by following weight portion.
Preparation method: each crude drug getting recipe quantity is ground into coarse powder respectively, decoct with water twice, add the water of medical material gross weight 6 times amount for the first time, decocting time is 2h, and second time adds the water of medical material gross weight 4 times amount, decocting time is 2h, merge decoction liquor, filter, after filtrate cools, adding ethanol to concentration is 60%, leave standstill 24 hours, reflux, extract, three times, return time is 2h, filter, filtrate recycling ethanol, is concentrated into extractum, and extract dry becomes fine powder, add pharmaceutically acceptable adjuvant again, mix homogeneously; Conveniently preparation technology is prepared into into buccal tablet, and every buccal tablet is containing crude drug 0.3g.
Embodiment 4
Each raw material is taken: Radix Rehmanniae 8 parts, Folium Sennae 10 parts, Cortex Moutan 6 parts, the Rhizoma Anemarrhenae 10 parts, Periostracum Cicadae 8 parts, Fructus Arctii 4 parts, Herba Schizonepetae 8 parts, 4 parts, Radix Glycyrrhizae by following weight portion.
Preparation method: each crude drug getting recipe quantity is ground into coarse powder respectively, decoct with water twice, add the water of medical material gross weight 6 times amount for the first time, decocting time is 2h, and second time adds the water of medical material gross weight 4 times amount, decocting time is 2h, merge decoction liquor, filter, after filtrate cools, adding ethanol to concentration is 60%, leave standstill 24 hours, reflux, extract, three times, return time is 2h, filter, filtrate recycling ethanol, is concentrated into extractum, and extract dry becomes fine powder, add pharmaceutically acceptable adjuvant again, mix homogeneously; Conveniently preparation technology is prepared into oral liquid, and every bottle containing crude drug 2g.
Embodiment 5
Each raw material is taken: Radix Rehmanniae 7 parts, Folium Sennae 9 parts, Cortex Moutan 5 parts, the Rhizoma Anemarrhenae 9 parts, Periostracum Cicadae 6 parts, Fructus Arctii 3 parts, Herba Schizonepetae 7 parts, 3 parts, Radix Glycyrrhizae by following weight portion.
Preparation method: each crude drug getting recipe quantity is ground into coarse powder respectively, decoct with water twice, add the water of medical material gross weight 7 times amount for the first time, decocting time is 2h, and second time adds the water of medical material gross weight 5 times amount, decocting time is 2h, merge decoction liquor, filter, after filtrate cools, adding ethanol to concentration is 60%, leave standstill 24 hours, reflux, extract, three times, return time is 2h, filter, filtrate recycling ethanol, is concentrated into extractum, and extract dry becomes fine powder, add pharmaceutically acceptable adjuvant again, mix homogeneously; Conveniently preparation technology is prepared into capsule, and every capsules is containing crude drug 0.3g.
Embodiment 6
Each raw material is taken: Radix Rehmanniae 9 parts, Folium Sennae 11 parts, Cortex Moutan 7 parts, the Rhizoma Anemarrhenae 11 parts, Periostracum Cicadae 10 parts, Fructus Arctii 5 parts, Herba Schizonepetae 9 parts, 5 parts, Radix Glycyrrhizae by following weight portion.
Preparation method: each crude drug getting recipe quantity is ground into coarse powder respectively, decoct with water twice, add the water of medical material gross weight 5 times amount for the first time, decocting time is 2h, second time adds the water of medical material gross weight 4 times amount, decocting time is 2h, merges decoction liquor, filters, obtain filtrate, after cooling, adding ethanol to concentration is 60%, leaves standstill 24 hours, reflux, extract, three times, return time is 2h, filters, filtrate recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, then adds pharmaceutically acceptable adjuvant, mix homogeneously; Conveniently preparation technology is prepared into capsule, and every capsules is containing crude drug 0.3g.
Embodiment 7 pharmaceutical composition xylol of the present invention causes the impact of mice ear
Get healthy ICR mice 40, ♀ ♂ half and half, divide 5 groups, 8/group, namely model group, positive controls (dexamethasone 20mg/kg), Chinese medicine composition of the present invention I group, II group, III group (obtain by Chinese medicine composition prescription described in embodiment 1,5,6 and preparation technology, dosage is 0.6g/kg, 0.1g/kg, 1.8g/kg, all by crude drug gauge).Every ig administration 1 time/d; Administration 14d, 60min after last medicine, mouse right ear uniform application dimethylbenzene 0.03mL/ only causes swollen, cuts ears and beat auricle and weigh after 2h, calculates ear swelling value (mg).Ear swelling value (mg)=auris dextra weight-left ear weight.
The impact of table 1. xylol induced mice ear swelling
| Group | Dosage (g/kg) | Ear swelling value (mg) |
| Model group | -- | 10.92±5.45 |
| Positive controls | 0.02 | 6.55±3.42 ** |
| I group | 0.6 | 5.92±3.12 **●▲※ |
| II group | 0.1 | 6.83±3.45 ** |
| III group | 1.8 | 6.72±3.50 ** |
Note: compare with model group,
*p < 0.01; Compare with positive controls,
●p < 0.05; Compare with II group,
▲p < 0.05; Compare with III group,
※p < 0.05.
The result display of table 1, compare with model group, pharmaceutical composition of the present invention and positive controls all significantly can reduce the ear swelling value (P < 0.01) of dimethylbenzene induced mice, show that pharmaceutical composition of the present invention has the effect of the mice ear significantly suppressing dimethylbenzene induction, show that medicament composing prescription compatibility of the present invention is reasonable, antiphlogistic effects is remarkable.Under same experiment condition, compared with positive controls, the present invention II group, III group, the present invention I group reduces the effect more remarkable (P < 0.05) of ear swelling value, and it is more reasonable that this also reflects the present invention's I group of prescription, and antiphlogistic effects is more remarkable.
The clinical observation of embodiment 8 medicine composite for curing acute pharyngitis of the present invention
1, case-data:
Include lung excess of the stomach pattern of fever case in reference to " acute inflammation of the throat " medicine typing standard in " People's Republic of China's traditional Chinese medicine industry standard Chinese medical disease Standardization of diagnosis and curative effect ", get rid of the patient of the other diseases such as tonsillitis, acute pyogenic infection of the pharynx simultaneously.Select patient 80 example of hospital ward and outpatient clinic.Be divided into two groups at random, treatment group 40 example, man 22 example, female 18 example; Age 23-55 year, average 34 years old; Matched group 40 example, man 24 example, female 16 example; Age 25-55 year, average 35 years old.All cases are all through clinical definite.Two groups of there was no significant differences in sex, age, the course of disease etc., have comparability.
2, case diagnosis standard:
1) pharyngalgia, state of an illness severe one has dysphagia and the disease such as aversion to cold, heating.
2) pharyngeal inspection: mucous hyperemia, swelling, lateral pharyngeal band is red and swollen, retropharyneal folliculosis.
3) onset is comparatively anxious, and the course of disease is shorter.
4) should differentiate with tonsillitis, acute pyogenic infection of the pharynx.
Lung sthenia gastropyrexia disease: pharyngalgia is more acute, thirsty polydipsia, cough, thick sputum, heating, defecates partially dry, oliguria with yellow urine.Pharyngeal congestion more very.Red tongue, yellow fur, rapid pulse is strong.
3, usage and dosage:
Treatment group: take medicine composite for curing of the present invention, capsule prepared by Example 1, every capsules containing crude drug amount 0.3g, every day 3 times, each 4-6 grain, after meal half an hour warm water delivery service.
Matched group: Amoxicillin Capsules (accurate word H44021351, the 0.25g*12s*2 plate of traditional Chinese medicines), a 0.5g, every day 3 times.
All treat 1 week for two groups, after 1 week, carry out therapeutic evaluation.
4, curative effect determinate standard:
1) clinical recovery: medication within 3 days symptom alleviate, within 1 week, clinical symptoms and sign disappear.
2) effective: medication within 5 days symptom alleviate, within 1 week, clinical symptoms and most of sign disappear.
3) effective: medication within 5 days symptom alleviate, within 1 week, clinical symptoms and part sign disappear.
4) invalid: medication can not make clinical symptoms and sign disappear within 1 week.
5, therapeutic effect:
In clinical observation process, patient all completes clinical observation.
Efficacy result statistics is as follows: clinical recovery 16 example (40%), effective 21 examples (52.5%), effective 3 examples (7.5%), invalid 0 example, total effective rate 100%, and clinical effectiveness is remarkable; Matched group clinical recovery 9 example (22.5%), effective 10 examples (25%), effective 9 examples (22.5%), invalid 12 examples (30%), total effective rate 70%.Two groups of total effective rates compare, and have significant difference, treatment group is significantly better than matched group, illustrate that medicine of the present invention is the active drug for the treatment of acute pharyngitis.In treatment group patient treatment procedure, vital sign steadily and without serious adverse reactions such as allergy, show that the clinical application of we is safely and effectively, is worth studying and applying further.
Claims (7)
1. treat the medicine of acute pharyngitis for one kind, it is characterized in that, it obtains primarily of the crude drug of following weight portion: Radix Rehmanniae 7-9 part, Folium Sennae 9-11 part, Cortex Moutan 5-7 part, Rhizoma Anemarrhenae 9-11 part, Periostracum Cicadae 6-10 part, Fructus Arctii 3-5 part, Herba Schizonepetae 7-9 part, Radix Glycyrrhizae 3-5 part.
2. medicine as claimed in claim 1, is characterized in that, it obtains primarily of the crude drug of following weight portion: Radix Rehmanniae 8 parts, Folium Sennae 10 parts, Cortex Moutan 6 parts, the Rhizoma Anemarrhenae 10 parts, Periostracum Cicadae 8 parts, Fructus Arctii 4 parts, Herba Schizonepetae 8 parts, 4 parts, Radix Glycyrrhizae.
3. the medicine as described in claim 1,2, is characterized in that, it is oral formulations.
4. medicine as claimed in claim 3, it is characterized in that, described solid orally ingestible is oral liquid, powder, granule, buccal tablet, electuary or capsule.
5. prepare the method for medicine as claimed in claim 4 for one kind, it is characterized in that, it comprises the following steps: each crude drug getting recipe quantity is ground into coarse powder respectively, decocts with water twice, adds the water of medical material gross weight 5-7 times amount for the first time, decocting time is 2h, second time adds the water of medical material gross weight 4-5 times amount, and decocting time is 2h, merges decoction liquor, filter, after filtrate cools, adding ethanol to concentration is 60%, leaves standstill 24 hours, reflux, extract, three times, return time is 2h, filters, filtrate recycling ethanol, be concentrated into extractum, extract dry becomes fine powder; Add pharmaceutically acceptable adjuvant again, mix homogeneously, conveniently technique is prepared into each dosage form.
6. the purposes of the medicine as described in claim 1,2 in the medicine of preparation treatment acute pharyngitis.
7. the purposes of the medicine as described in claim 1,2 in the medicine of preparation treatment lung excess of the stomach pattern of fever acute pharyngitis.
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Application publication date: 20150513 |