CN101380411A - Traditional Chinese medicine preparation for relieving cough and reducing sputum - Google Patents

Traditional Chinese medicine preparation for relieving cough and reducing sputum Download PDF

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CN101380411A
CN101380411A CNA2008100729675A CN200810072967A CN101380411A CN 101380411 A CN101380411 A CN 101380411A CN A2008100729675 A CNA2008100729675 A CN A2008100729675A CN 200810072967 A CN200810072967 A CN 200810072967A CN 101380411 A CN101380411 A CN 101380411A
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chinese medicine
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adjuvant
herba
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何茁
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Abstract

The invention relates to the traditional Chinese medicine pharmacy field, in particular to a Chinese medicinal herb used for curing diseases such as colds and coughs and acute and chronic tracheitis, etc. The Chinese medicinal herb comprises four medicines of monarch drug in a prescription, adjuvant drug, adjuvant and conductant drug. The oral preparation is prepared by using existing conventional traditional Chinese medicine pharmacy technique and excipients, wherein, the components of the medicine are moxibustion ephedrine, bitter almond, cordate houttuynia, agrimony, golden buckwheat rhizone, geranium nepalense, prunella, caladium, cicada slough, larva of a silkworm withbatrytis, scorpion, lumbricus, chilopod and liquorice. The invention has more satisfactory healing efficacy on coughs and acute and chronic tracheitis which are caused by colds; the total cure rate is 78.08% and the total effective rate can reach 95.47%.

Description

The Chinese medicine preparation of relieving cough and resolving phlegm
Technical field
The present invention relates to field of traditional Chinese medicine pharmacy, relate to particularly with diseases such as treatment by Chinese herbs cold cough, acute and chronic tracheitis.
Background technology
Diseases such as common flu, bronchitis, pneumonia, pharyngitis and asthma all can cause bad diseases such as cough, expectoration, asthma, laryngopharynx swelling and pain, doctor trained in Western medicine mainly adopts the antibiotic medicine to carry out antiinflammatory clinically, when increasing the weight of, the state of an illness then adopt antibiosis usually to treat, but adopt western medical treatment not have the disease-resistant potential of effective exciting human, make and to ask for great treatment only minor illness that obstinate spends thousands of units easily and curative effect does not show, increase patient's financial burden on foot, and be mostly to cure the symptoms, not the disease.
Traditional Chinese medical science medical science is of long standing and well established, and modern Chinese medicine adopts traditional Chinese herbal medicine to treat this type of disease, can reach the effect for the treatment of both the principal and secondary aspects of a disease.The traditional Chinese medical science is thought the many YANG QI deficiency that cause because of suffering from a deficiency of the kidney of this type of disease, make body resistance against diseases descend, cause in the cold intrusive body and must not dissolve, causing in the body cold virus and toxin thereof eventually can not effectively remove, and causes respiratory system freely not cause diseases such as cough, asthma, laryngopharynx swelling and pain.
Through State Intellectual Property Office's internet retrieval, the Chinese medicine composition or the preparation that much relate to the treatment preventing phlegm from forming and stopping coughing are arranged, below only choose two examples, prior art as a comparison:
Documents 1: " Chinese medicine preparation of relieving cough and resolving phlegm and production method thereof ", its Granted publication number: CN10039623C, open day be: 2006.10.4 Granted publication day is: 2008.2.20, " a kind of Chinese medicine preparation particularly can be treated the Chinese medicine preparation and the production method thereof of cough, asthma, laryngopharynx swelling and pain to this disclosure of the Invention.Said preparation is to be made by Herba Ephedrae, Gypsum Fibrosum, Semen Armeniacae Amarum, the Radix Stemonae, Flos Farfarae, Bulbus Fritillariae Thunbergii, Cortex Mori, Herba Houttuyniae, Caulis Mahoniae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, it is according to China's Chinese medicine theory, give the medicine of some heat-clearing and toxic substances removing, dispersing and descending lung-QI, blood circulation promoting and blood stasis dispelling, spleen invigorating QI invigorating, make it have the heat clearing away of inducing sweat, relieving cough and resolving phlegm and relieving exterior-interior syndrome, the effect that alleviates respiratory tract disease.Through pharmacodynamics test and clinical trial, obtained better therapeutic effect.", its major defect is: this side only is suitable for treating the disease of lung-heat, but sympotoms caused by cold factors are not suitable for, and also may cause retroaction sometimes.
Documents 2: " a kind of medicine for the treatment of tachypnea, cough with asthma, coughing up phlegm ", its Granted publication number: CN1301120C, open day 2006.1.18, Granted publication day is: 2007.2.21, this disclosure of the Invention " a kind of medicine for the treatment of tachypnea, cough with asthma, coughing up phlegm; it is to be raw material with Herba Ephedrae (processed), Pheretima, Semen Armeniacae Amarum, Herba Houttuyniae, Radix Platycodonis, Fructus Xanthii, Pulvis concha Mactrae, Radix Glycyrrhizae, Flos Magnoliae, Flos Farfarae, and is according to the different qualities of every flavor Chinese medicine, formulated in proportion.Medicine of the present invention is used for clinical treatment tachypnea, cough with asthma, coughs up phlegm, have pleasantly relieving asthma, the effect of cough-relieving expectoration, antiinflammatory antiallergic and detoxifcation.", its major defect is: though this side is stronger to the disease effect of treatment tachypnea, cough with asthma, it is not enough that its power of reducing phlegm is owed slightly.
My clinical practice by is for many years used and is found, Herba Ephedrae and Semen Armeniacae Amarum, Radix Glycyrrhizae compatibility can strengthen the effect of relieving cough and asthma effectively.The Herba Ephedrae opening lung-energy is with antiasthmatic-antitussive, and the Semen Armeniacae Amarum lowering the adverse-rising QI to resolve phlegm is with antiasthmatic-antitussive, and Radix Glycyrrhizae grows and coughs lung moistening and cough-relieving is quenched the thirst; Herba Ephedrae property is fiery and forthright, and Semen Armeniacae Amarum is soft and moist, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, and three medicines share, and can play the effect that strengthens antiasthmatic-antitussive.
Herba Ephedrae also has the effect of tangible depressed lung-energy dispersing except diaphoresis with drugs pungent in flavor and warm in nature, the cold expelling that induces sweat.Every wind and cold invades outward, a hair key bundle closes and cause lung qi and must not declare logical diseases caused by exogenous pathogenic factor to breath with cough, all available Herba Ephedrae treatment.Herba Ephedrae diaphoresis diuresis is stronger, a little less than the moxibustion Herba Ephedrae diaphoresis power, is particularly useful for cough and asthma.Herba Ephedrae (processed) is generally concocted with Mel, to play the dry property that relaxes Herba Ephedrae, the effect that effect is rather coughed in the increase lung moistening.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine preparation that effect obviously is used for the treatment of diseases such as cold cough, acute and chronic tracheitis that has.
The present invention's technical scheme disclosed and protection is: the Chinese medicine preparation of relieving cough and resolving phlegm is characterized in the oral formulations of being formed and being made by following bulk drugs employing existing conventional pharmaceutical technology (tcd) and adjuvant by monarch drug, ministerial drug, adjuvant drug and messenger drug four class medicines; Wherein, the monarch drug weight portion is: Herba Ephedrae (processed) 12-18; The ministerial drug weight portion is: Semen Armeniacae Amarum 12-18, Herba Houttuyniae 24-36, Herba Agrimoniae 24-36, Rhizoma Fagopyri Dibotryis 24-36, geranium 24-36, BAIYIXIAKUCAO 24-36; The adjuvant drug weight portion is: Bulbus Fritillariae Uninbracteatae 8-12, Periostracum Cicadae 10-15, Bombyx Batryticatus 8-12, Scorpio 4-6, Pheretima 12-18, Scolopendra 4-6; The messenger drug weight portion is: Radix Glycyrrhizae 24-36.
As improvement of the technical scheme, wherein preferred, the monarch drug weight portion is: Herba Ephedrae (processed) 15; The ministerial drug weight portion is: Semen Armeniacae Amarum 15, Herba Houttuyniae 30, Herba Agrimoniae 30, Rhizoma Fagopyri Dibotryis 30, geranium 30, BAIYIXIAKUCAO 30; The adjuvant drug weight portion is: Bulbus Fritillariae Uninbracteatae 10, Periostracum Cicadae 12, Bombyx Batryticatus 10, Scorpio 5, Pheretima 15, Scolopendra 5; The messenger drug weight portion is: Radix Glycyrrhizae 30.
Combination according to the crude drug of above-mentioned composition form of the present invention, mix with the multi-form auxiliary adding ingredient of acceptable in the oral drug preparation and corresponding the processing after, can be made into the oral drugs of corresponding different dosage forms with existing conventional pharmaceutical technology (tcd) and adjuvant, as the oral drugs of pill, granule, capsule, powder, tablet or other solid preparation form; Can also make oral drugs as liquid preparation forms such as water decoction, syrup.
The present invention is made up of 14 flavor Chinese medicines, and its compatibility characteristics are that lung qi dispersing gas is relievingd asthma and coughed diseases such as treating acute and chronic tracheitis and cold cough.Herba Ephedrae have the effect of lung qi dispersing gas, flat cough with asthma and is monarch drug.Sharp lung qi falls in Semen Armeniacae Amarum, falls with Herba Ephedrae compatibility one a surname one, and function falls in a surname who recovers lung qi, more help with the falling clearly of Herba Houttuyniae, Herba Agrimoniae, Rhizoma Fagopyri Dibotryis, geranium, Herba Ajugae, and the merit that strengthens depressed lung-energy dispersing is to be ministerial drug.Bulbus Fritillariae Uninbracteatae, Periostracum Cicadae, Bombyx Batryticatus, Scorpio, Scolopendra, Pheretima can be reduced phlegm and the spasm of separating air flue is to be adjuvant drug, and Radix Glycyrrhizae can warming the middle warmer and descending qi, cough-relieving is quenched the thirst, and coordinating the actions of various ingredients in a prescription is to be messenger drug.All medicine compatibilities are played strengthening vital QI to eliminate pathogenic factors altogether, improve the body disease-resistant function, to reach the effect of relieving cough and asthma effectively.
The Chinese crude drug effect of each component of the present invention:
The little hardship of Herba Ephedrae-Xin Wen, diaphoresis cold expelling, depressed lung-energy dispersing, relieving cough and expelling phlegm.Be usually used in treating anemofrigid cold, uncomfortable in chest breathing with cough, bronchial asthma.
Herba Houttuyniae-suffering, be slightly cold the detoxifcation of purging heat, eliminating carbuncle evacuation of pus.Can be used for dyspnea and cough due to lung-heat.
Geranium-hardship, hot, flat, dispel rheumatism; Be used for rheumatic arthralgia.
Rhizoma Fagopyri Dibotryis-little suffering, puckery, cold; Heat-clearing and toxic substances removing, the evacuation of pus blood stasis dispelling.
Herba Ajugae-hardship is sweet, and is cold, clearing away lung-heat to relieve cough, and the merit of have cough-relieving, eliminate the phlegm, relievining asthma can be used for treating diseases such as tracheitis.
Herba Agrimoniae-suppressing the hyperactive liver pathogenic fire reducing, antitussive is antipruritic. control the cough due to lung-heat,
Semen Armeniacae Amarum-warm in nature, bitter in the mouth; Slightly poisonous.The sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.Be usually used in cough and asthma, fullness in the chest abundant expectoration, withered, the dryness of the intestine constipation in blood deficiency Tianjin.
Bulbus Fritillariae Uninbracteatae-cold nature and sweet-bitter flavor is gone into the cardiopulmonary warp, but lung moistening, cough-relieving, reduce phlegm.
Periostracum Cicadae-suffering, sweet, cold, expelling wind to relieve convulsion
Bombyx Batryticatus-expelling wind for relieving convulsion, dissipating phlegm and resolving masses.
Scorpio-suffering, flat, poisonous; Spasmolytic, antiinflammatory counteracting toxic substances, removing obstruction in the collateral to relieve pain relieve dizziness, high fever, infantile convulsions, epilepsy, etc.
Scolopendra-suffering, warm, poisonous; The spasmolytic that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., merit poison eliminating stagnation, removing obstruction in the collateral to relieve pain.
Pheretima-property is salty-cold, clearing away heat and relieving spasm; Can be used for diseases such as cough with asthma, headache conjunctival congestion, laryngopharynx swelling and pain.
The flat sweet in the mouth of Radix Glycyrrhizae-property, but invigorating the spleen and replenishing QI are grown and to be coughed lung moistening, and cough-relieving is quenched the thirst, and are in harmonious proportion hundred medicines.
The clinical drug effect checking of Chinese medicine preparation of the present invention:
One, the preparation of test medicine of the present invention " cough syrup ":
With the weight portion ratio, ratio in Herba Ephedrae (processed) 15, Semen Armeniacae Amarum 15, Herba Houttuyniae 30, Herba Agrimoniae 30, Rhizoma Fagopyri Dibotryis 30, geranium 30, BAIYIXIAKUCAO 30, Bulbus Fritillariae Uninbracteatae 10, Periostracum Cicadae 12, Bombyx Batryticatus 10, Scorpio 5, Pheretima 15, Scolopendra 5 and Radix Glycyrrhizae 30 is got Chinese crude drug ready, crushed after being dried becomes fine powder, cross and standbyly behind the 80-120 order dusting cover extract twice with decocting, each 1-2 hours, extracted twice liquid is merged and be condensed into the clear paste that relative concentration is 1.10-1.15 (50-70 ℃), standby.Refine into simple syrup with sucrose in right amount with distilled water in addition; With simple syrup and standby clear paste mix homogeneously, according to being routinely added to an amount of preservative benzoic acid, add distilled water again to capacity, packing is promptly then.
Two, instructions of taking:
Every day 3 times, each 25ml, warm water delivery service.
Three, treatment time:
Take 10 days courses of treatment uninterruptedly.
Four, identifying object and therapeutic outcome:
In recent years, the clinical treatment that " cough syrup " is applied to certain institute of traditional Chinese medicine reached nearly thousand routine patients, by the observation analysis to clinical data, proved that the present invention has comparatively satisfied curative effect for treatment because of cough and the various acute and chronic tracheitis that flu causes.
2004-2,006 three years clinical inpatients are added up for 397 person-times, and wherein the cough that causes of flu is 157 person-times, cures to reach 128 person-times, transfers 22 person-times well to, and invalid is 7 person-times, and cure rate can reach 81.52%, and effective percentage can reach 95.5%; 132 person-times of acute tracheitiss, healing reaches 106 person-times, transfers 21 person-times well to, and invalid is 5 person-times, and cure rate can reach 80.30%, and effective percentage can reach 96.21%; 108 person-times of chronic tracheitiss, healing reaches 76 person-times, transfers 26 person-times well to, and invalid is 6 person-times, and cure rate can reach 70.37%, and effective percentage can reach 94.44%; Its total cure rate is 78.08%, and total effective rate can reach 95.47%.
Five, untoward reaction: all case is not seen untoward reaction, provable its safety.
Six, conclusion:
Practice according to traditional Chinese medical science pharmacology and clinical treatment can draw: " cough syrup " has the effect and the effect of diseases such as good curing cold cough, acute and chronic tracheitis really, can be widely used in clinical treatment and use.
The specific embodiment
The preparation of embodiment 1, extract
The ratio of Herba Ephedrae (processed) 15, Semen Armeniacae Amarum 15, Herba Houttuyniae 30, Herba Agrimoniae 30, Rhizoma Fagopyri Dibotryis 30, geranium 30, BAIYIXIAKUCAO 30, Bulbus Fritillariae Uninbracteatae 10, Periostracum Cicadae 12, Bombyx Batryticatus 10, Scorpio 5, Pheretima 15, Scolopendra 5 and Radix Glycyrrhizae 30 is got Chinese crude drug ready, twice of the water boiling and extraction that adds 8 times of amounts, the each decoction about 2 hours, merge routinely and filter, leave standstill, filter, it is the clear paste of 1.15-1.20 (50-70 ℃) that concentrating under reduced pressure becomes relative density, and this clear paste is active component extract.
The preparation of embodiment 2, oral agents
The active component extract that embodiment 1 extracted is equipped with corresponding medicinal adjuvant (dextrin, magnesium stearate etc.) can adopt conventional pharmaceutical technology can make dosage forms such as granule and capsule.For example: resulting clear paste among the embodiment 1 is added starch, mixing, spray drying is granulated, and drying adds 0.5% magnesium stearate mix homogeneously again and makes graininess, incapsulates and can obtain capsule.
The preparation of embodiment 3, powder
Weight portion ratio scope according to Herba Ephedrae (processed) 12-18, Semen Armeniacae Amarum 12-18, Herba Houttuyniae 24-36, Herba Agrimoniae 24-36, Rhizoma Fagopyri Dibotryis 24-36, geranium 24-36, BAIYIXIAKUCAO 24-36, Bulbus Fritillariae Uninbracteatae 8-12, Periostracum Cicadae 10-15, Bombyx Batryticatus 8-12, Scorpio 4-6, Pheretima 12-18, Scolopendra 4-6, Radix Glycyrrhizae 24-36 is got the former material of Chinese medicine ready, crushed after being dried becomes fine powder, cross 80-120 order dusting cover, can get fine powder after getting the fine powder dry heat sterilization again, directly be powder (can take after mixing it with hot water) after the pack.
The preparation of embodiment 4, tablet
With the weight portion ratio, weight portion ratio in Herba Ephedrae (processed) 12, Semen Armeniacae Amarum 12, Herba Houttuyniae 24, Herba Agrimoniae 24, Rhizoma Fagopyri Dibotryis 24, geranium 24, BAIYIXIAKUCAO 24, Bulbus Fritillariae Uninbracteatae 8, Periostracum Cicadae 10, Bombyx Batryticatus 8, Scorpio 4, Pheretima 12, Scolopendra 4, Radix Glycyrrhizae 24 is got Chinese crude drug ready, produces pharmaceutical technology according to routine and can be made into tablet.
The preparation of embodiment 5, electuary
With the weight portion ratio, the weight portion ratio of Herba Ephedrae (processed) 18, Semen Armeniacae Amarum 18, Herba Houttuyniae 36, Herba Agrimoniae 36, Rhizoma Fagopyri Dibotryis 36, geranium 36, BAIYIXIAKUCAO 36, Bulbus Fritillariae Uninbracteatae 12, Periostracum Cicadae 15, Bombyx Batryticatus 12, Scorpio 6, Pheretima 18, Scolopendra 6, Radix Glycyrrhizae 36 is got Chinese crude drug ready, and pharmaceutical technology can be made into electuary routinely.
The preparation of embodiment 6, syrup
With the weight portion ratio, ratio in Herba Ephedrae (processed) 15, Semen Armeniacae Amarum 15, Herba Houttuyniae 30, Herba Agrimoniae 30, Rhizoma Fagopyri Dibotryis 30, geranium 30, BAIYIXIAKUCAO 30, Bulbus Fritillariae Uninbracteatae 10, Periostracum Cicadae 12, Bombyx Batryticatus 10, Scorpio 5, Pheretima 15, Scolopendra 5 and Radix Glycyrrhizae 30 is got Chinese crude drug ready, crushed after being dried becomes fine powder, cross and standbyly behind the 80-120 order dusting cover extract twice with decocting, each 1-2 hours, extracted twice liquid is merged and be condensed into the clear paste that relative concentration is 1.10-1.15 (50-70 ℃), standby.Refine into simple syrup with sucrose in right amount with distilled water in addition; With simple syrup and standby clear paste mix homogeneously, the preservative benzoic acid that adds routinely about 0.2% is received or benzoic acid, adds water to capacity again, and packing promptly then.
Present invention focuses on to provide a kind of Chinese medicine preparation that is used for the treatment of diseases such as cold cough, acute and chronic tracheitis, its core is its each component and proportioning thereof.The invention is not restricted to the above embodiment of lifting; can make various oral formulations with existing conventional pharmaceutical processing technology; above example is intended to exemplify the simple embodiment that is suitable for of the present invention; under the situation that does not deviate from the invention spirit and essence thereof; be familiar with all equivalent variations of making according to the present invention of those of ordinary skill in the art, all should belong to the protection domain that claims of the present invention limit.

Claims (4)

1, a kind of Chinese medicine preparation of relieving cough and resolving phlegm, it is made up of monarch drug, ministerial drug, adjuvant drug and messenger drug four class medicines and adopts existing conventional pharmaceutical technology (tcd) and adjuvant and the oral formulations made by following bulk drugs; Wherein, described monarch drug weight portion is: moxibustion Herba Ephedrae 12-18; Described ministerial drug weight portion is: Semen Armeniacae Amarum 12-18, Herba Houttuyniae 24-36, Herba Agrimoniae 24-36, Rhizoma Fagopyri Dibotryis 24-36, geranium 24-36, BAIYIXIAKUCAO 24-36; Described adjuvant drug weight portion is: Bulbus Fritillariae Uninbracteatae 8-12, Periostracum Cicadae 10-15, Bombyx Batryticatus 8-12, Scorpio 4-6, Pheretima 12-18, Scolopendra 4-6; Described messenger drug weight portion is: Radix Glycyrrhizae 24-36.
2, the Chinese medicine preparation of relieving cough and resolving phlegm according to claim 1, wherein, described monarch drug weight portion is: moxibustion Herba Ephedrae 15; Described ministerial drug weight portion is: Semen Armeniacae Amarum 15, Herba Houttuyniae 30, Herba Agrimoniae 30, Rhizoma Fagopyri Dibotryis 30, geranium 30, BAIYIXIAKUCAO 30; Described adjuvant drug weight portion is: Bulbus Fritillariae Uninbracteatae 10, Periostracum Cicadae 12, Bombyx Batryticatus 10, Scorpio 5, Pheretima 15, Scolopendra 5; Described messenger drug weight portion is: Radix Glycyrrhizae 30.
3, the Chinese medicine preparation of relieving cough and resolving phlegm according to claim 1 and 2, wherein, described oral formulations includes water decoction, pill, granule, capsule, powder, tablet or the oral liquid made from existing conventional pharmaceutical technology (tcd) and adjuvant.
4, the application of Chinese medicine composition according to claim 1 and 2 in the Chinese medicine preparation of preparation relieving cough and resolving phlegm.
CNA2008100729675A 2008-10-14 2008-10-14 Traditional Chinese medicine preparation for relieving cough and reducing sputum Pending CN101380411A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102688428A (en) * 2012-05-31 2012-09-26 张西菊 Chinese medicinal atomized liquid for relieving cough and reducing sputum
CN104721766A (en) * 2013-12-19 2015-06-24 上海市嘉定区中医医院 Chinese medicinal composition for treatment of cough and asthma, preparation method and application thereof
CN105168931A (en) * 2015-09-29 2015-12-23 济南伟传信息技术有限公司 Traditional Chinese medicine composite for treating chronic trachitis
CN112316065A (en) * 2020-06-05 2021-02-05 武汉立志保健品有限责任公司 Chinese medicinal compound preparation for treating new coronary pneumonia

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102688428A (en) * 2012-05-31 2012-09-26 张西菊 Chinese medicinal atomized liquid for relieving cough and reducing sputum
CN102688428B (en) * 2012-05-31 2014-01-29 张西菊 Chinese medicinal atomized liquid for relieving cough and reducing sputum
CN104721766A (en) * 2013-12-19 2015-06-24 上海市嘉定区中医医院 Chinese medicinal composition for treatment of cough and asthma, preparation method and application thereof
CN104721766B (en) * 2013-12-19 2019-04-02 上海市嘉定区中医医院 The Chinese medicine composition and its preparation method and application for treating cough and asthma
CN105168931A (en) * 2015-09-29 2015-12-23 济南伟传信息技术有限公司 Traditional Chinese medicine composite for treating chronic trachitis
CN112316065A (en) * 2020-06-05 2021-02-05 武汉立志保健品有限责任公司 Chinese medicinal compound preparation for treating new coronary pneumonia

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