CN112316065A - Chinese medicinal compound preparation for treating new coronary pneumonia - Google Patents

Abstract

A compound Chinese medicinal preparation and oral liquid for treating, relieving and relieving fever in winter cold season, dry cough, and asthenia; double ephedra and fritillaria prescription. Comprises herba Ephedrae, herba Ephedrae preparata, semen Armeniacae amarum, Bulbus Fritillariae Cirrhosae, Bulbus Fritillariae Thunbergii, radix Platycodi, rhizoma Phragmitis, and Glycyrrhrizae radix. The medicine is also suitable for patients with common cold, fever, dry cough and hypodynamia; according to the theory of treatment based on syndrome differentiation of traditional Chinese medicine, the symptoms are the same as the therapeutic formula. The prescription has effects of relieving exterior syndrome, dispelling cold, dispersing lung qi, and relieving cough. In 29 months of 1 year 2020, the news was published and published in the hundred seats news website.

Description

Chinese medicinal compound preparation for treating new coronary pneumonia

The technical field is as follows:

the invention relates to a Chinese medicinal compound preparation for treating, relieving and relieving fever in winter cold season, dry cough and hypodynamia which are main symptoms of new coronary pneumonia; is a decoction or a mixture, and is packaged into oral liquid. Prepared by adding, subtracting and changing the combination of ephedra decoction from Shanghai treatise on Cold-induced diseases; the treatise on Cold-induced diseases is written in the book Zhang Zhong Jing of the east Han dynasty.

The invention relates to a dual ephedra fritillary prescription, which is also called a dual ephedra fritillary prescription for ChengZhi. [ coronavirus pneumonia traditional Chinese medicine formula: fever and dry cough in winter cold season; chinese ephedra, mix-fried Chinese ephedra each 6 g; 12 g of almond; sichuan fritillary bulb and thunberg fritillary bulb each 12 g; 15 parts of platycodon grandiflorum; 24 g of reed rhizome; licorice root, radix Glycyrrhizae Praeparata 6 g. Herba Ephedrae and semen Armeniacae amarum have effects of inducing sweat, relieving exterior syndrome, dispersing lung qi, and relieving cough; ephedrine expands bronchus; is beneficial to the discharge of sputum and virus. Bulbus Fritillariae Cirrhosae and Bulbus Fritillariae Thunbergii have antitussive and expectorant effects, and relax smooth muscles of bronchus; the platycodon grandiflorum has the effects of eliminating phlegm, relieving cough and resisting inflammation; rhizoma phragmitis has the effects of clearing heat and promoting fluid production, eliminating phlegm and expelling pus; it is combined with Jie Geng to remove lung sepsis; licorice root, radix Glycyrrhizae coordinates the effects of the other drugs and clears away heat and toxic materials! "C (B)

Typical symptoms of new coronary pneumonia: fever, dry cough and hypodynamia are the main manifestations; a few patients are accompanied by the symptoms of nasal obstruction, watery nasal discharge, pharyngalgia, diarrhea and muscular soreness; lung sepsis develops and severe persons develop dyspnea. Early as common cold; the new coronary pneumonia has infectivity, and the nucleic acid detection is positive. The common cold is not contagious. (the country has issued the first to seventh releases). The traditional Chinese medicine compound preparation can treat early-stage new coronary pneumonia with symptoms of winter cold season fever, dry cough and hypodynamia as main symptoms; and is suitable for patients with common cold, fever, dry cough and asthenia in winter and spring. According to the theory of treatment based on syndrome differentiation, the prescription is a traditional Chinese medicine prescription for treating cold in winter and cold in early spring and lung-attacked by wind-cold; has the effects of relieving exterior syndrome, dispelling cold, dispersing lung qi and relieving cough.

Background

Excess syndrome, Ma Huang Tang syndrome; [ PRIOR ] Sun disease, headache, fever, body pain, lumbago, arthralgia, aversion to wind, asthma without sweat, and is mainly treated with Ma Huang Tang. (treatise on typhoid fever, Shanghai science and technology Press, first edition of 5 months in 1985; page 26)

Ephedra, cassia twig, almond and licorice. [ EFFECT ] induce sweat to release exterior, ventilate lung and relieve dyspnea. [ INDICATIONS ] the syndrome of exterior excess due to exogenous wind-cold. Aversion to cold, fever, headache, body pain, no sweat, dyspnea, thin and white tongue coating, and superficial and tense pulse. [ APPLICATION ] 1 the recipe is a representative prescription for treating exterior syndrome due to exogenous wind-cold. The key points of the treatment are aversion to cold, fever, no sweat, dyspnea and superficial and tense pulse. Because it is a drastic herb with pungent and warm naturation, it is contraindicated in Shang Han Lun for treating "sores", "stranguria", "epistaxis", "bleeding, exogenous exterior deficiency, spontaneous sweating, blood deficiency and pulse accompanied by" late pulse in chi ", and" heavy palpitation "due to mistaking down. 2. Common cold, influenza, acute bronchitis and bronchial asthma are all the patients with exterior syndrome due to wind-cold and excess syndrome, and can be treated by the recipe. [ ATTACHMENT ] TRI-BORONG TANG (Taiping Huimin and He Ji Ju Fang); ephedra, almond and licorice. The efficacy is as follows: to ventilate lung and relieve exterior syndrome. The main treatment is as follows: common cold, wind pathogen, stuffy nose, loud voice, cough and chest stuffiness. (formulary, Shanghai science and technology Press, 6 months in 1995, 1 st edition, pages 18 to 19)

Herba ephedrae: unprocessed and stir-baked with honey; pungent, slightly bitter and warm. It enters lung and bladder meridians. Induce sweating to release exterior, free the lung-qi, relieve dyspnea, induce diuresis to alleviate edema. Can be used for treating wind-cold type common cold, cough, asthma, and edema due to wind-damp evil. Unprocessed for sweating and relieving exterior syndrome, stir-baked with honey for relieving cough and dyspnea. It has strong dispersing power. It should be used with cautions for spontaneous sweating due to exterior deficiency, night sweat due to yin deficiency and dyspnea due to deficiency.

Cassia twig: pungent and sweet with warm property enter heart, lung and bladder meridians. Induce sweating to expel pathogenic factors from the muscles, warm and dredge meridians, strengthen yang and transform qi. Can be used for treating common cold due to wind-cold, pain due to cold accumulation and blood stagnation, phlegm retention, and water retention, and palpitation. It is contraindicated for exogenous febrile disease, fire excess due to yin deficiency, recklessly blood flow due to blood heat because it is pungent and warm in property and can tonify yang, and it is easy to damage yin and move blood.

Almond (bitter almond): bitter and slightly warm; has little toxicity. It enters lung and large intestine meridians. Relieve cough and dyspnea, moisten intestines to relieve constipation. Can be used for treating cough, asthma, and constipation due to intestinal dryness.

Licorice root: unprocessed or stir-baked with honey. Sweet and neutral. It is entered into the heart, lung, spleen and stomach. Tonify qi, strengthen the middle energizer, clear away heat and toxic material, dispel phlegm, relieve cough, relieve spasm, alleviate pain, and harmonize property of the drugs. Can tonify qi of heart and spleen, is used for treating excessive phlegm cough, relieving spasm and pain, relieving the severity or alleviating the toxic and side effects of the medicine, and clearing away heat and toxic materials.

Balloon flower: bitter, pungent and even. It enters lung meridian. Disperse lung qi, resolve phlegm, relieve sore throat and expel pus. Can be used for treating cough with excessive phlegm, chest distress, sore throat, loss of throat, lung abscess, cough with purulent phlegm.

Bulbus Fritillariae Cirrhosae: bitter, sweet and slightly cold. It enters lung and heart meridians. Can be used for treating cough due to asthenia, cough due to lung heat and dryness, scrofula, sore, mammary abscess, and pulmonary abscess.

Thunberg fritillary bulb: bitter and cold. It enters lung and heart meridians. Clear heat and resolve phlegm, relieve depression and dissipate nodulation. It can be used for treating wind-heat, dryness-heat, phlegm-heat cough, scrofula, goiter, carbuncle, ulcer, and pulmonary abscess.

Reed rhizome: sweet and cold in nature. It enters lung and stomach meridians. Clear heat and promote fluid production, relieve restlessness and arrest vomiting. Can be used for treating fever, polydipsia and stomach diseases. Vomiting due to adverse rising of heat, it is indicated for cough due to lung heat, lung abscess and vomiting of pus. (TCM recorded in TCM, Shanghai science and technology Press, first 6 months, 1995).

The Shanghai science and technology publishing society of traditional Chinese medicine pharmacology; first edition of month 1 of 2008, pages 37 to 39. Extracting: ma Huang is pungent, slightly bitter and warm in nature. It enters lung and bladder meridians. Has effects of inducing sweat, relieving exterior syndrome, dispersing lung qi, relieving asthma, inducing diuresis, and relieving swelling. Can be used for treating common cold due to wind-cold, chest distress, cough, and edema; bronchial asthma. The pharmacological action is as follows: sweating, relieving asthma, strengthening muscle strength, increasing blood pressure, resisting inflammation, resisting allergy, exciting central nervous system, and other effects. Note that: in the specification of the pharmacopoeia of the people's republic of China in 2005 edition, the ephedrine hydrochloride content of the ephedra is not less than 1% calculated according to dry products, the ephedrine content is limited to 20-90 mg calculated according to the recommended dosage of 2-9 g in the pharmacopoeia of the people's republic of China, and the ephedrine hydrochloride content is equivalent to the common dosage of clinical ephedrine hydrochloride. Ephedrine hydrochloride, pseudoephedrine hydrochloride, herba Ephedrae extract, and herba Ephedrae extract are all used as psychotropic drugs.

Bitter apricot kernel, bitter in taste, slightly warm in nature and slightly toxic. It enters lung and large intestine meridians. Has the effects of relieving cough and asthma, loosening bowel to relieve constipation, and the like. Can be used for treating cough, asthma, chest fullness, excessive phlegm, blood deficiency, dry body fluid, intestinal dryness, and constipation. The pharmacological action is as follows: eliminating phlegm, relieving cough, relieving asthma, enhancing immunity, resisting tumor, resisting inflammation, relieving pain, and other effects.

Licorice root, radix Glycyrrhizae is sweet in flavor and neutral in nature. It has effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature. The pharmacological action is as follows: the adrenocortical hormone has the effects of regulating immunity, relieving cough, eliminating phlegm, resisting inflammation, resisting allergic reaction, resisting bacteria, resisting virus, removing toxic substance, resisting arrhythmia, reducing blood lipid, resisting atherosclerosis, and resisting tumor. Modern pharmacology proves that the Chinese medicinal compound preparation has exact and reliable medical effect on the diseases with fever, dry cough and hypodynamia as main symptoms.

Disclosure of Invention

The invention relates to a Chinese medicinal composition for treating fever, dry cough and hypodynamia caused by cold winter; later on, the new coronary pneumonia develops into sepsis. The Chinese medicinal composition comprises 6 g of ephedra, 6 g of fried ephedra, 12 g of bitter apricot kernel (almond), 12 g of bulbus fritillariae cirrhosae, 12 g of thunberg fritillary bulb, 15 g of platycodon grandiflorum, 24 g of reed rhizome and 6 g of liquorice. The traditional Chinese medicine composition of the application is a brand-new formula, and the prior art is not recorded to be similar to the formula. The invention relates to ephedra, namely mix-fried ephedra (monarch drug); bitter apricot seeds, liquorice (ministerial drug); platycodon grandiflorum, bulbus fritillariae cirrhosae and thunberg fritillary bulb (adjuvant); phragmites communis rhizome (guiding drug). The use method comprises the following steps: decoction, mixture and single-package oral liquid; the instant decoction is taken without adding preservative, and the preservative and the flavoring agent are added in large-scale production; the antiseptic comprises sodium benzoate, ethyl p-hydroxybenzoate (or ethylparaben), and potassium sorbate; the correctant includes sucrose, stevioside, and saccharin sodium.

The compound traditional Chinese medicine preparation is a famous prescription of Chinese dynasty and Song dynasty pharmacopoeia, is used for treating diseases according to symptoms, and has already proved the medical effect; and need not be further demonstrated.

In the prescription, in order to reduce the drastic property of the ephedra, the mix-fried ephedra is adopted in half dosage; the rhizoma phragmitis is aggravated in weight, the effects of clearing heat and promoting fluid can prevent the warm and dry Chinese ephedra, and the rhizoma phragmitis has the functions of expelling lung and removing sepsis; the compatibility is creative.

The fact that the ephedra decoction in Shang Han Lun (treatise on Cold-induced diseases) has the effects of inducing sweat, relieving exterior syndrome, ventilating lung and relieving asthma is determined for thousands of years. Subtracting ramulus Cinnamomi to obtain Sanao decoction; is a monarch and ministerial drug of the dual ephedra fritillary prescription.

The 'Taiping Huimin He Ji Ju Fang' is the original prescription of the Song Dynasty official drug administration, the pharmacopoeia compiled by the head official, and the prescription recorded in the Sanao Tang; the medical effect is positive!

The licorice has the effects of tonifying qi and strengthening the middle-jiao, can tonify qi of heart and spleen, and is effective in treating the symptoms of hypodynamia. Adjuvant drugs such as platycodon grandiflorum, bulbus fritillariae cirrhosae, thunberg fritillary bulb and rhizoma phragmitis for relieving cough and reducing sputum, clearing heat and expelling pus, and promoting the production of body fluid and moistening lung are added to a patient with fever, dry cough and hypodynamia as main symptoms; the preparation has improved therapeutic effect and reduced side effects. The main components of the ephedra include ephedrine and pseudoephedrine, levo-ephedrine, dextro-pseudoephedrine, mutual stereoisomer, which are phenylpropylamine derivatives; the stability of the intramolecular hydrogen bond formed by the conjugate acid of pseudoephedrine and C-OH is greater than that of ephedrine.

The differentiation of the disease location in TCM is mainly classified into zang-fu organ differentiation, six-meridian differentiation, wei-defensive qi-ying-blood differentiation and trifocal differentiation. Differentiation of syndromes of wei-defensive, qi, ying-nutrient and blood and of syndromes of triple energizer are commonly used in the traditional Chinese medicine treatment of infectious diseases. The creativity of the invention lies in the theoretical updating, and the ephedra decoction from Shanghai treatise on the new coronary pneumonia for the first time; enriches the vision field of differentiation of six meridians and the theory of clinical treatment of infectious diseases.

Differentiation of syndromes by six meridians is established in Shang Han Lun by Zhang Zhong Jing of Chinese physicians. Differentiation of syndromes according to six meridians the different syndromes of exogenous diseases in the development and development process are classified into three-yang diseases (taiyang disease, yangming disease, shaoyang disease) and three-yin diseases (taiyin disease, shaoyin disease, jueyin disease) according to yin and yang principles. Syndrome of cold injury from the greater yang: pathogenic wind-cold attacking the taiyang meridians and causing aversion to cold, a strong and painful head and neck and a floating pulse. For exterior syndrome due to external wind-cold, Ma Huang Tang is a typical prescription for relieving exterior syndrome with pungent and warm natured drugs.

Differentiation of syndromes according to the theory of wei-defensive qi, ying-nutrient and blood is a differentiation of syndromes for treating exogenous febrile diseases established by "chapter of exogenous febrile diseases" from "Tianshi of family of Qing Dynasty medical sciences and physicians of Qing Dynasty. The "external cold and warm chapter" points out: the dialectic qi of the ying and the dialectic blood of the ying are behind the defense. The pathogenic heat entering from the mouth and nose firstly invades the lung, enters the blood from the ying-nutrient part and the wei-defensive part and qi, and then enters the blood from qi, so the disease condition gradually deepens. The three-jiao syndrome differentiation is proposed in Wu Jutong "Wen Bing tiao Bian" of Qing Dynasty doctor, and the various syndromes of exogenous febrile disease are summarized as the upper, middle and lower three-jiao syndromes. The representative prescription is Yinqiao powder, sang Ju Yin. Yinqiao san (Lonicera and Forsythia syndrome differentiation & treatment of epidemic febrile diseases): fructus forsythiae, honeysuckle, platycodon grandiflorum, mint, bamboo leaves, raw liquorice, schizonepeta, fermented soybean and great burdock achene. Pungent and cool to expel superficial evils, clear heat and remove toxicity. The onset of warm disease. Fever without sweating, or sweating disorder, slight aversion to wind-cold, headache, thirst, cough, pharyngalgia, red tongue tip, thin white or yellowish fur, and superficial and rapid pulse. Sang Ju Yin (sang Ju Yin) (differentiation of epidemic febrile diseases) is: mulberry leaf, chrysanthemum, almond, forsythia, mint, platycodon root, liquorice and reed root (reed rhizome). Dispel wind and clear heat, ventilate lung and relieve cough. The wind temperature is at the beginning. But cough, mild fever, slight fever in mouth, and superficial and rapid pulse. (diagnostics of traditional Chinese medicine, Shanghai science and technology Press; 1 st edition in 12 months 2006, 142 pages, 137 pages, 138 pages, 143 pages in seventh chapter, 142 pages, 143 pages in syndrome differentiation, Ministry of medicine, Shanghai science and technology Press; 1 st edition in 6 months in 1995, 28-29 pages).

In 6 days 2 and 6 months in 2020, the lung-clearing and toxin-expelling decoction printed by the national health and health committee and the national institute of traditional Chinese medicine in combination with the 'Notification of lung-clearing and toxin-expelling decoction' on the recommendation of using the lung-clearing and toxin-expelling decoction in the combined treatment of new coronary pneumonia by traditional Chinese and western medicines comprises the traditional Chinese medicine classic formulas of Maxingshigan decoction, blackberry lily Mahuang decoction, Xiaochaihu decoction and Wuling san. The main drugs are ephedra, almond and liquorice. The prescription of the Chinese ephedra and fritillaria is the same as the monarch and ministerial medicines. The current national recommended prescriptions have proved the medical effect, and the treatment effect of the invention can also be confirmed! The invention is published and announced earlier than the recommended lung-heat clearing and toxin expelling soup for eight days.

The Chengli dual ephedra fritillary virus pneumonia is dialectical; prescription of Chinese medicine for treating coronavirus pneumonia: fever and dry cough in winter cold season; chinese ephedra, mix-fried Chinese ephedra each 6 g; 12 g of almond (bitter almond); sichuan fritillary bulb and thunberg fritillary bulb each 12 g; 15 parts of platycodon grandiflorum; 24 g of reed rhizome; licorice root, radix Glycyrrhizae Praeparata 6 g. Herba Ephedrae and semen Armeniacae amarum have effects of inducing sweat, relieving exterior syndrome, dispersing lung qi, and relieving cough; ephedrine expands bronchus; is beneficial to the discharge of sputum and virus. Bulbus Fritillariae Cirrhosae and Bulbus Fritillariae Thunbergii have antitussive and expectorant effects, and relax smooth muscles of bronchus; the platycodon grandiflorum has the effects of eliminating phlegm, relieving cough and resisting inflammation; rhizoma phragmitis has the effects of clearing heat and promoting fluid production, eliminating phlegm and expelling pus; it is combined with Jie Geng to remove lung sepsis; licorice root, radix Glycyrrhizae coordinates the effects of the other drugs and clears away heat and toxic materials! Summer 12 g for thick and sticky phlegm; 15 g of orange red; 18 g of tuckahoe; and 15 g of scutellaria baicalensis is added into the yellow wine. For patients with excessive heat and dry cough, 12 g of rhizoma anemarrhenae is added; 8 g of snakegourd peel; 20 g of bergamot pear. For patients with light phlegm and severe cough, 5 g of thin pungent herbs are added; 10 g of dried ginger, 50 g of gypsum for heavy patients; for chest pain, add Ting Li Zi 10 g.

The traditional Chinese medicine compound preparation is a practical proved formula. The application of the method in winter is used as data information. Examples of treatment by differentiation of syndromes: cold in winter, common cold due to wind-cold; syndrome of wind-cold invading the lung (wind-cold attacking the lung). Some certain, female, 40 years old; 2011, 1 month, 25 days; [ clinical manifestations ] cough, dry cough with little phlegm, aversion to cold, fever, nasal obstruction, sore throat, tiredness, debilitation; pain in the body without sweating, thin and white coating on the tongue, and superficial and tense pulse. (Note: this case is different from diagnostics of traditional Chinese medicine, Shanghai science and technology Press, second 8 months in 2011, page 119 (the manifestation of the syndrome of wind-cold attacking the lung is different) [ therapeutic prescriptions ] double ephedra and fritillary bulb prescriptions, three prescriptions, improvement after taking, fever, and cough relief

Detailed Description

The raw materials prepared before the preparation are calculated according to the amount of 10000ml of liquid medicine:

ephedra herb, herba Ephedrae 6 g × 50; mix-fried ephedra herb 6 g is multiplied by 50; bitter apricot kernel, semen Armeniacae amarum 12 g, x 50; sichuan fritillary bulb 12 g × 50; thunberg fritillary bulb 12 g multiplied by 50; 15 g of balloonflower root and 50 times; 24 g of reed rhizome is multiplied by 50; licorice root, radix Glycyrrhizae 6 g × 50. Drinking water; a proper amount of preservative; and a proper amount of flavoring agent. (Chinese ephedra 300 g, bitter apricot seed 600 g, Sichuan fritillary bulb 600 g, thunberg fritillary bulb 600 g, balloonflower root 750 g, reed rhizome 1200 g, licorice 300 g.)

The dosage of the double ephedra fritillaria prescription is 200ml of solution for each prescription; each prescription of the traditional Chinese medicine is 93 g, and the traditional Chinese medicine is dissolved in 200ml of liquid, namely 46.5 percent g/ml.

The Chinese medicinal decoction pieces are soaked in drinking water and decocted. The process comprises the following steps: 1. decocting twice, and mixing; 2. purifying, filtering the extractive solution to remove impurities, and collecting supernatant; 3. concentrating, filtering, concentrating the clear solution, and adding antiseptic and correctant to required amount; 4, subpackaging (filling) and sealing in a container; 5. and (3) sterilization, wherein: sometimes sterilized and then filled.

Claims (2)

1. One can treat, relieve and relieve symptoms of fever in winter cold season, dry cough and hypodynamia; a few patients have other symptoms accompanied by nasal obstruction, watery nasal discharge, pharyngalgia, diarrhea and muscular soreness; and the nucleic acid detection result is positive early stage new coronary pneumonia; and the Chinese medicinal compound preparation for detecting the common cold with negative nucleic acid is a mixture and an oral liquid single package, and is characterized in that the Chinese medicinal composition contains Chinese ephedra, mix-fried Chinese ephedra, bitter apricot seed, bulbus fritilariae, thunberg fritillary bulb, platycodon grandiflorum, reed rhizome and liquorice.

2. The traditional Chinese medicine composition as claimed in claim 1, wherein the dosage is 6 g of ephedra herb, 6 g of mix-fried ephedra herb, 12 g of bitter apricot seed, 12 g of unibract fritillary bulb, 12 g of thunberg fritillary bulb, 15 g of platycodon root, 24 g of reed rhizome and 6 g of liquorice; the process for producing the oral liquid comprises the steps of decocting water, soaking the traditional Chinese medicine decoction pieces; decocting, mixing decoctions, purifying, concentrating, adding antiseptic and correctant, bottling, sealing, and sterilizing.