CN105381291A - Traditional Chinese medicine composition for preventing and treating pneumonia, preparation method and applications thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating pneumonia, preparation method and applications thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for preventing and/or treating pneumonia. Pholidota chinensis is taken as the monarch drug and then is compounded with reed root, welsh onion stalk, loquat leaf, ephedra stem, fritillaria cirrhosa, honeysuckle flower, kelp, perilla, dandelion, and haw. The traditional Chinese medicine has a prominent and quick effect on treating pneumonia, and is suitable for clinical treatment of various pneumonias. The relapse is difficult.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition preventing and/or treating pneumonia and its preparation method and application.
Background technology
Pneumonia refers to the inflammation of last air flue, alveolar and interstitial lung, it is a kind of ancient disease, the Egyptian mummy of 1200 BC just have found the evidence that pneumonia exists, pneumonia can by pathogenic microorganism, immunologic injury, allergy and drug-induced, cause the cause of disease of pneumonia complicated and changeable, comprise antibacterial, virus, mycoplasma etc.The clinical symptoms of pneumonia mainly comprises heating, cough, dyspnea, the visible inflammatory infiltration shade of conducting lung X-ray examination.Before antibiotic occurs, the mortality rate of pneumonia is up to 1/3rd, and antibiotic appearance, the very big mortality rate reducing pneumonia, but the pneumonia of one of commonly encountered diseases as department of pediatrics, still can cause the death of about 1,400,000 children every year.Change because of organism aging process, Respiratory ft tive resistance causes the defence of whole body respiratory tract local and immunologic function to reduce, and the mortality rate of the old people that pneumonia causes is also very high.
Doctor trained in Western medicine for the treatment of pneumonia generally according to the treatment such as different choice antibiotic, hormone of its cause of disease, there is the advantage of instant effect, can be used for the treatment of pneumonia especially severe pneumonia, but it is not thorough to there is treatment yet, easy recurrence, the shortcoming that side effect is large, as SARS epidemic period, due to the use of the hormone of heavy dose, although play a significant role for alleviation symptoms of pneumonia, saved the life of a lot of boiling point patient, but result also in the side effect such as serious femur head necrosis, greatly reduce patient more after quality of life.
The traditional Chinese medical science takes the dialectical method treated for the treatment of pneumonia, there is side effect little, the advantage for the treatment of both the principal and secondary aspects of a disease, pneumonia is divided into by the different traditional Chinese medical science according to clinical symptoms: (1) wind-heat invading the lung: show as rapid breathing, have antiperspirant, thirsty, slight agitation, swallowing red, tongue fur BOHUANG, red tip of the tongue, often laying particular emphasis on loose wind heat clearing away, lung qi dispersing cough-relieving when treating; (2) cold closed lung type, symptom mainly contains cough, rapid breathing, generates heat not high, lossless, aversion to cold, thin white fur of tongue, and body of the tongue is light red, floating and tense pulse, lays particular emphasis on expelling wind and cold during treatment, relieving cough and relieving asthma; (3) phlegm-heat closed lung type, symptom is primarily of fever without perspiration or hypohidrosis, and cough, breathes heavily and suppress, rale, abdominal distention, fullness in the chest, dysphoria, yellowish fur, red tongue, rolling pulse, lay particular emphasis on removing heat-phlegm during treatment, lung qi dispersing opening and closing, lowering the adverse QI to relieve asthma; (4) exterior cold and interior heat type, symptom mainly contains that high heat is lossless, cough is breathed heavily and suppressed, and dysphoria, muffle pastiness, flaring of alaenasi, red tongue, yellow fur, attaches most importance to lung qi dispersing cold expelling, clearing heat and relieving dyspnea during treatment.
Pseudobulbus Pholidotae Chinensis, have another name called tor lotus, stone Fructus Canarii albi, for pseudobulb or the herb of orchid Pseudobulbus Pholidotae Chinensis, there is effect of nourishing YIN and moistening the lung, heat-clearing and toxic substances removing, dampness removing repercussive, it is the common drug of the symptoms such as cough due to lung-heat, as Pseudobulbus Pholidotae Chinensis herb can be used for treating pneumonia with after crystal sugar decoction, Chinese patent CN101940760A discloses after Pseudobulbus Pholidotae Chinensis and Radix Curcumae, Folium Artemisiae Argyi, Poria, Cortex Mori, Radix Peucedani, Flos Inulae, Herba Houttuyniae, Radix Codonopsis, Flos Caryophylli, Folium Eriobotryae etc. combine and can be used for treating chronic bronchitis; Chinese patent CN103417841A discloses Pseudobulbus Pholidotae Chinensis and basket eucalyptus globulus, reddish tone father-in-law, Flos Gomphrenae, Herba Tripterospermi, jingle bell bean, Caulis Marsdeniae Tenacissimae, northern bedstraw, Herba Equiseti Arvinsis, Herba Hedyotis scandentis, Fructus Mume, Plantula Brassicae chinensis etc. and combines and can be used for treating pneumonia; Chinese patent CN104338040A discloses that Pseudobulbus Pholidotae Chinensis and Herba Schizonepetae, Concretio Silicea Bambusae, Rhizoma Cynanchi Stauntonii, Fructus Trichosanthis, Semen Lepidii (Semen Descurainiae) combine can safe and effective treatment chronic pneumonia; Chinese patent CN104888011A discloses a kind of Chinese medicinal capsule for the treatment of pneumonia and preparation method thereof, and described Chinese medicine is made up of Shi Shanglian, Herba Houttuyniae, Folium Isatidis, Herba Ardisiae Japonicae, Folium Eriobotryae, Eucheuma muricatum (Gmel.) Web.Van Bos., Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Radix Angelicae Sinensis, Herba Taraxaci, Semen Lepidii (Semen Descurainiae), Bulbus Allii Fistulosi, Pericarpium Citri Reticulatae, Herba Ephedrae, Fructus Perillae, Rhizoma Imperatae, Fructus Forsythiae, Radix Platycodonis, Flos Chrysanthemi, Radix Gentianae, Radix Glycyrrhizae.
Summary of the invention
The invention provides a kind of Chinese medicine composition comprising the treatment pneumonia of Pseudobulbus Pholidotae Chinensis newly, by there is the effect for the treatment of pneumonia significantly with the compatibility of Rhizoma Phragmitis, Bulbus Allii Fistulosi, Folium Eriobotryae, Herba Ephedrae, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Thallus Laminariae (Thallus Eckloniae), Folium Perillae, Herba Taraxaci, Fructus Crataegi, rapid-action, not easily recur, be suitable for the clinical treatment of various pneumonia.
On the one hand, the invention provides a kind of Chinese medicine composition preventing and/or treating pneumonia, it is prepared from by the raw material of following weight proportion: Pseudobulbus Pholidotae Chinensis 10-15 part, Rhizoma Phragmitis 5-8 part, Bulbus Allii Fistulosi 3-5 part, Folium Eriobotryae 3-5 part, Herba Ephedrae 3-5 part, Bulbus Fritillariae Cirrhosae 3-5 part, Flos Lonicerae 3-5 part, Thallus Laminariae (Thallus Eckloniae) 1-3 part, Folium Perillae 1-3 part, Herba Taraxaci 1-3 part, Fructus Crataegi 1-3 part.
Preferably prevent and/or treat the Chinese medicine composition of pneumonia, be prepared from by the raw material of following weight proportion: Pseudobulbus Pholidotae Chinensis 12 parts, Rhizoma Phragmitis 8 parts, Bulbus Allii Fistulosi 3 parts, Folium Eriobotryae 4 parts, 4 parts, Herba Ephedrae, Bulbus Fritillariae Cirrhosae 4 parts, Flos Lonicerae 4 parts, Thallus Laminariae (Thallus Eckloniae) 3 parts, Folium Perillae 3 parts, Herba Taraxaci 2 parts, Fructus Crataegi 2 parts.
On the other hand, the invention provides a kind of preparation method preventing and/or treating the Chinese medicine composition of pneumonia, it comprises the following steps:
(1) get the raw materials ready: take Pseudobulbus Pholidotae Chinensis, Rhizoma Phragmitis, Bulbus Allii Fistulosi, Folium Eriobotryae, Herba Ephedrae, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Thallus Laminariae (Thallus Eckloniae), Folium Perillae, Herba Taraxaci, Fructus Crataegi by formula;
(2) extract: add raw material of Chinese medicine medicine 5-10 50-80% ethanol doubly, reflux, extracts 2-3 time, and filtrate merges;
(3) concentrated: the decompression filtrate recycling ethanol after extraction is to without alcohol taste, and when being concentrated into 25 DEG C, the clear paste of 1.2-1.3, to obtain final product;
The ethanol of 75% of 8 times amount is added, heating and refluxing extraction 2 times in preferred step (2).
Chinese medicine composition clear paste of the present invention can add pharmaceutically acceptable adjuvant and be prepared into conventional peroral dosage form, and described dosage form comprises tablet, capsule, pill, granule, powder etc.
Again on the one hand, the invention still further relates to above-mentioned Chinese medicine composition and prepare the purposes prevented and/or treated in the medicine of pneumonia.
In crude drug used in the present invention:
Pseudobulbus Pholidotae Chinensis: yin nourishing, heat clearing away, dampness removing, dissipating blood stasis.Cure mainly cough due to lung-heat, spit blood, dizzy, headache, nocturnal emission, laryngopharynx swelling and pain, rheumatalgia, damp and hot edema, dysentery, leucorrhea, infantile malnutrition, traumatic injury;
Rhizoma Phragmitis: sweet, cold.Attach to the lung and stomach meridians.Clearing away heat-fire, promoting the production of body fluid to quench thirst, relieving restlessness, preventing or arresting vomiting, diuresis;
Bulbus Allii Fistulosi: pungent, warm; Relieving the exterior syndrome by diaphoresis, dispelling cold and activating YANG;
Folium Eriobotryae: lung heat clearing, stomach function regulating, sending down the abnormal ascending QI, quenches the thirst.Cure mainly cough due to lung-heat, deficiency of YIN chronic cough, gastric heat is vomitted the sound of vomiting, and pregnancy reactions, quenches one's thirst, lung-wind syndrome acne vulgaris;
Herba Ephedrae: pungent, micro-hardship, temperature.Return lung, urinary bladder channel.Heating is induced sweat, antiasthmatic-antitussive, inducing diuresis to remove edema;
Bulbus Fritillariae Cirrhosae: sweet, bitter, be slightly cold.Return lung, heart channel.Removing heat-phlegm, nourishing the lung to arrest cough, mass dissipating and swelling eliminating;
Flos Lonicerae: pungent, cold.Return lung, stomach, the heart, large intestine channel.Heat-clearing and toxic substances removing, dispelling wind to relieve the exterior syndrome, thin throat, relieving restlessness of relieving summer heat;
Thallus Laminariae (Thallus Eckloniae): salty, returns liver, stomach, kidney channel; Hard masses softening and resolving, expectorant diuretic;
Folium Perillae: pungent, temperature.Return lung meridian.Sending down the abnormal ascending QI expectorant, intestine moistening of relievining asthma;
Herba Taraxaci: sweet, micro-hardship, cold.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds;
Fructus Crataegi: acid is sweet, and tepor, returns spleen, stomach, Liver Channel, promoting digestion and invigorating the stomach, circulation of qi promoting scattered silt, for meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain, hyperlipemia etc.
Beneficial effect of the present invention:
The present invention take Pseudobulbus Pholidotae Chinensis as monarch drug, by the combination with Rhizoma Phragmitis, Bulbus Allii Fistulosi, Folium Eriobotryae, Herba Ephedrae, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Thallus Laminariae (Thallus Eckloniae), Folium Perillae, Herba Taraxaci, Fructus Crataegi, there is the effect of significant treatment pneumonia, and rapid-action, not easily repeatedly, the treatment of clinical various pneumonia is suitable for.
Detailed description of the invention
Following examples are intended to illustrate that the present invention instead of the present invention further limit, and the present invention can implement by the either type described in summary of the invention.
Embodiment 1: a kind of Chinese medicine composition preventing and/or treating pneumonia, it is prepared from by the raw material of following weight proportion:
Pseudobulbus Pholidotae Chinensis 12g, Rhizoma Phragmitis 8g, Bulbus Allii Fistulosi 3g, Folium Eriobotryae 4g, Herba Ephedrae 4g, Bulbus Fritillariae Cirrhosae 4g, Flos Lonicerae 4g, Thallus Laminariae (Thallus Eckloniae) 3g, Folium Perillae 3g, Herba Taraxaci 2g, Fructus Crataegi 2g.
Described Chinese medicine composition is prepared by the following method, and concrete comprises the following steps:
(1) get the raw materials ready: take Pseudobulbus Pholidotae Chinensis, Rhizoma Phragmitis, Bulbus Allii Fistulosi, Folium Eriobotryae, Herba Ephedrae, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Thallus Laminariae (Thallus Eckloniae), Folium Perillae, Herba Taraxaci, Fructus Crataegi by formula;
(2) extract: 75% ethanol adding raw material of Chinese medicine medicine 8 times, reflux, extracts 2 times, and filtrate merges;
(3) concentrated: the decompression filtrate recycling ethanol after extraction to without alcohol taste, when being concentrated into 25 DEG C 1.2 clear paste, clear paste adds tabletting after pharmaceutically acceptable adjuvant, obtains the Chinese medicinal tablet that the present invention prevents and/or treats pneumonia;
Embodiment 2: a kind of Chinese medicine composition preventing and/or treating pneumonia, it is prepared from by the raw material of following weight proportion:
Pseudobulbus Pholidotae Chinensis 10g, Rhizoma Phragmitis 5g, Bulbus Allii Fistulosi 3g, Folium Eriobotryae 5g, Herba Ephedrae 5g, Bulbus Fritillariae Cirrhosae 3g, Flos Lonicerae 5g, Thallus Laminariae (Thallus Eckloniae) 3g, Folium Perillae 3g, Herba Taraxaci 3g, Fructus Crataegi 3g.
Described Chinese medicine composition is prepared by following methods, and concrete comprises the following steps:
(1) get the raw materials ready: take Pseudobulbus Pholidotae Chinensis, Rhizoma Phragmitis, Bulbus Allii Fistulosi, Folium Eriobotryae, Herba Ephedrae, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Thallus Laminariae (Thallus Eckloniae), Folium Perillae, Herba Taraxaci, Fructus Crataegi by formula;
(2) extract: 50% ethanol adding raw material of Chinese medicine medicine 10 times, reflux, extracts 3 times, and filtrate merges;
(3) concentrated: the decompression filtrate recycling ethanol after extraction to without alcohol taste, when being concentrated into 25 DEG C 1.2 clear paste, load gelatine capsule shell after adding pharmaceutically acceptable adjuvant, obtain the Chinese medicine capsules that the present invention prevents and/or treats pneumonia;
Embodiment 3: a kind of Chinese medicine composition preventing and/or treating pneumonia, it is prepared from by the raw material of following weight proportion:
On the one hand, the invention provides a kind of Chinese medicine composition preventing and/or treating pneumonia, it is prepared from by the raw material of following weight proportion: Pseudobulbus Pholidotae Chinensis 15g, Rhizoma Phragmitis 5g, Bulbus Allii Fistulosi 3g, Folium Eriobotryae 3g, Herba Ephedrae 5g, Bulbus Fritillariae Cirrhosae 5g, Flos Lonicerae 3g, Thallus Laminariae (Thallus Eckloniae) 2g, Folium Perillae 2g, Herba Taraxaci 2g, Fructus Crataegi 3g.
Described Chinese medicine composition is prepared by following methods, and concrete comprises the following steps:
(1) get the raw materials ready: take Pseudobulbus Pholidotae Chinensis, Rhizoma Phragmitis, Bulbus Allii Fistulosi, Folium Eriobotryae, Herba Ephedrae, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Thallus Laminariae (Thallus Eckloniae), Folium Perillae, Herba Taraxaci, Fructus Crataegi by formula;
(2) extract: 80% ethanol adding raw material of Chinese medicine medicine 10 times, reflux, extracts 2 times, and filtrate merges;
(3) concentrated: the decompression filtrate recycling ethanol after extraction to without alcohol taste, when being concentrated into 25 DEG C 1.2 clear paste, be prepared into granule after adding pharmaceutically acceptable adjuvant, obtain the Chinese medicine granules that the present invention prevents and/or treats pneumonia;
Effect example: the prevention effect of pneumonia
1, experimental subject, patients with pneumonia 120 example of clinical definite, wherein man 60 example, female 60 example, the age be 5-75 year between, be divided into two groups at random, give the Chinese medicine composition group preventing and/or treating pneumonia of (1) embodiment of the present invention 1 respectively, oral, one time 4, three times on the one, warm water takes after meal; (2) according to the Chinese medicinal capsule that patent CN104888011A embodiment 1 prepares, oral, one time 4, three times on the one, warm water takes after meal, record patient take medicine after clinical symptoms change and healing time, statistics effective percentage.
2, curative effect judging standard:
Cure: clinical symptoms is generated heat, cough, disappearance of coughing up phlegm, and temperature recovery is normal;
Effective: clinical symptoms is generated heat, cough, alleviation of coughing up phlegm, body temperature reduces;
Invalid: clinical symptoms is generated heat, cough, cough up phlegm without alleviate and/or increase the weight of, body temperature does not fall and/or raises;
Effective percentage=(curing number of cases+effectively number of cases)/60 × 100%
Table 1 patients with pneumonia clinical trial results
Clinical trial results shows Chinese medicine composition of the present invention and has significant therapeutic effect for pneumonia, and total effective rate reaches 98.33%, and rapid-action, short treating period, therefore, is suitable for the clinical treatment of pneumonia.
Model case:
Money, female, 56 years old, x-ray was diagnosed as pneumonia, heating, body temperature 38.6 DEG C, cough, take Chinese medicine composition of the present invention after 8 days clinical symptoms disappear completely.
Wang, man, 69 years old, x-ray was diagnosed as pneumonia, and cough is suppressed and breathed heavily, and heating is lossless, body temperature 38.4 DEG C, take Chinese medicine composition of the present invention after 12 days temperature recovery normal, clinical symptom disappearance.
Lee, man, 6 years old, x-ray was diagnosed as pneumonia, cough is suppressed and is breathed heavily, and sleep and cough in morning increase the weight of, and generate heat 37.5 DEG C, take azithromycin after 5 days symptom slightly alleviate, but still fever on and off, time medical, x-ray is diagnosed as pneumonia, takes Chinese medicine composition of the present invention clinical symptom disappearance after 14 days.
Content of the present invention merely illustrates some claimed specific embodiments; one of them or more described technical characteristic can be combined with arbitrary one or more technical scheme in technical scheme; these technical schemes obtained through combination also in the application's protection domain, just as these technical schemes obtained through combination in the disclosure of invention concrete record.
Claims (7)
1. prevent and/or treat a Chinese medicine composition for pneumonia, it is characterized in that being prepared from by the raw material of following weight proportion: Pseudobulbus Pholidotae Chinensis 10-15 part, Rhizoma Phragmitis 5-8 part, Bulbus Allii Fistulosi 3-5 part, Folium Eriobotryae 3-5 part, Herba Ephedrae 3-5 part, Bulbus Fritillariae Cirrhosae 3-5 part, Flos Lonicerae 3-5 part, Thallus Laminariae (Thallus Eckloniae) 1-3 part, Folium Perillae 1-3 part, Herba Taraxaci 1-3 part, Fructus Crataegi 1-3 part.
2. the Chinese medicine composition preventing and/or treating pneumonia according to claim 1, is characterized in that being prepared from by the raw material of following weight proportion: Pseudobulbus Pholidotae Chinensis 12 parts, Rhizoma Phragmitis 8 parts, Bulbus Allii Fistulosi 3 parts, Folium Eriobotryae 4 parts, 4 parts, Herba Ephedrae, Bulbus Fritillariae Cirrhosae 4 parts, Flos Lonicerae 4 parts, Thallus Laminariae (Thallus Eckloniae) 3 parts, Folium Perillae 3 parts, Herba Taraxaci 2 parts, Fructus Crataegi 2 parts.
3. the Chinese medicine composition preventing and/or treating pneumonia according to claim 1 and 2, is characterized in that adding pharmaceutically acceptable adjuvant is prepared into peroral dosage form.
4. the Chinese medicine composition preventing and/or treating pneumonia according to claim 3, is characterized in that described peroral dosage form is selected from tablet, capsule, pill, granule or powder.
5. the preparation method preventing and/or treating the Chinese medicine composition of pneumonia described in claim 1-4, is characterized in that comprising the following steps:
(1) get the raw materials ready: take Pseudobulbus Pholidotae Chinensis, Rhizoma Phragmitis, Bulbus Allii Fistulosi, Folium Eriobotryae, Herba Ephedrae, Bulbus Fritillariae Cirrhosae, Flos Lonicerae, Thallus Laminariae (Thallus Eckloniae), Folium Perillae, Herba Taraxaci, Fructus Crataegi by formula;
(2) extract: add raw material of Chinese medicine medicine 5-10 50-80% ethanol doubly, reflux, extracts 2-3 time, and filtrate merges;
(3) concentrated: the decompression filtrate recycling ethanol after extraction is to without alcohol taste, and when being concentrated into 25 DEG C, the clear paste of 1.2-1.3, adds pharmaceutically acceptable adjuvant and be prepared into peroral dosage form, to obtain final product.
6. the preparation method preventing and/or treating the Chinese medicine composition of pneumonia according to claim 5, is characterized in that the ethanol adding 75% of 8 times amount in step (2), heating and refluxing extraction 2 times.
7. the Chinese medicine composition described in any one of claim 1-4 is preparing the purposes prevented and/or treated in the medicine of pneumonia.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114931214A (en) * | 2022-03-30 | 2022-08-23 | 无限极（中国）有限公司 | Chinese herbal medicine composition for improving hearing impairment and preparation method and application thereof |
| CN115040619A (en) * | 2022-05-27 | 2022-09-13 | 博济医药科技股份有限公司 | A Chinese medicinal composition and its application in preparing medicine for treating pneumonia |
Citations (1)
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| CN104888011A (en) * | 2015-06-17 | 2015-09-09 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine capsule for treating pneumonia and preparation method of traditional Chinese medicine capsule |
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2015
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104888011A (en) * | 2015-06-17 | 2015-09-09 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine capsule for treating pneumonia and preparation method of traditional Chinese medicine capsule |
Non-Patent Citations (1)
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| 中国人民解放军第三十一野战院: "《丰顺常用中草药》", 31 July 1973 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114931214A (en) * | 2022-03-30 | 2022-08-23 | 无限极（中国）有限公司 | Chinese herbal medicine composition for improving hearing impairment and preparation method and application thereof |
| CN114931214B (en) * | 2022-03-30 | 2024-05-07 | 无限极（中国）有限公司 | Chinese herbal medicine composition for improving hearing impairment and preparation method and application thereof |
| CN115040619A (en) * | 2022-05-27 | 2022-09-13 | 博济医药科技股份有限公司 | A Chinese medicinal composition and its application in preparing medicine for treating pneumonia |
| CN115040619B (en) * | 2022-05-27 | 2023-08-08 | 博济医药科技股份有限公司 | Traditional Chinese medicine composition and application thereof in preparation of medicine with function of treating pneumonia |
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