CN105031556A - Chinese herb preparation for treating cough variant asthma - Google Patents
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- CN105031556A CN105031556A CN201510602326.6A CN201510602326A CN105031556A CN 105031556 A CN105031556 A CN 105031556A CN 201510602326 A CN201510602326 A CN 201510602326A CN 105031556 A CN105031556 A CN 105031556A
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Abstract
The invention discloses a Chinese herb preparation for treating the cough variant asthma. The Chinese herb preparation comprises the raw material herbs of embelia parviflora, bicolor limonium, choerospondias axillaries, straw nutgrass galingale rhizome, radix curcumae, balloon flowers, uncaria roots, honeysuckle stems, passion flowers, stiff silkworms, lindley eupatorium herbs and pearl viburnum fruits. The Chinese herb preparation for treating the cough variant asthma has the advantages of having a remarkable treatment effect, being free of side effects, making a patient have good compliance and the like. The Chinese herb preparation for treating the cough variant asthma is decocted with water to treat 36 patients for four weeks, the result shows that 10 patients are cured through clinical treatment, and the preparation shows an effect on 13 patients and is effective for 9 patients and ineffective for 4 patients, and therefore the total effective rate is 88.9%.
Description
Technical field
The present invention relates to Chinese medicine sciemtifec and technical sphere, particularly a kind of Chinese medicine preparation for the treatment of cough variant asthma.
Background technology
The specific type asthma that cough variant asthma is is feature with chronic, intractable cough, cough is its main or unique clinical manifestation, and the patient of about 35.7% will develop into typical asthma in 5 years.Cough variant asthma often in morbidity at night or aggravation, has a strong impact on the quality of life of patient.Current cough variant asthma western medical treatment mainly inhaled, although most of patient can take effect at short notice, symptom of coughing after discontinuing medication is easy repeatedly, and some patients can not adhere to medication because worrying the side effect of hormone.Chinese medicine cough variant asthma has some superiority, few side effects, and patient compliance is good, short term effect and doctor trained in Western medicine close, late result is better.But along with climate warming, the change of mass food and drink custom and the quickening of rhythm of life, the traditional Chinese medical science pathogeny of cough variant asthma also there occurs change.Therefore, again inquire into the traditional Chinese medical science pathogeny of cough variant asthma, the Chinese medicine preparation of research and development treatment cough variant asthma has important clinical significance.
Summary of the invention
The object of the invention is to the deficiency overcoming prior art, namely provide one to treat cough variant asthma Chinese medicine preparation.
In order to realize foregoing invention object, the invention provides following technical scheme: a kind of Chinese medicine preparation for the treatment of cough variant asthma, be made up of the crude drug of following mass ratio: Radix seu Caulis Embeliae Parviflorae 15 ~ 25 parts, Herba Limoii Bicoloris 20 ~ 30 parts, Fructus Choerospondiatis 30 ~ 50 parts, Juncus amplifolius A. Camus 3 ~ 9 parts, Radix Curcumae 6 ~ 12 parts, Radix Platycodonis 6 ~ l0 part, Radix Uncariae rhynchophyllae 20 ~ 40 parts, Caulis Lonicerae 10 ~ 30 parts, Herba Passiflorae Caeruleae 10 ~ 20 parts, Bombyx Batryticatus 6 ~ 10 parts, Herba Eupatorii Lindleyani 30 ~ 50 parts, Fructus Viburni Ceanothoidis 9 ~ 15 parts.
The pharmacological action of raw material of Chinese medicine medicine of the present invention is as follows:
Radix seu Caulis Embeliae Parviflorae: bitter, puckery, warm.Tonifying blood and regulating menstruation, strong waist knee joint.Cure mainly anemia, amenorrhea, menoxenia, leucorrhea, lumbago and skelalgia.
Herba Limoii Bicoloris: sweet, micro-hardship, flat.Benefiting vital QI and blood, dissipating blood stasis stops blooding.Cure mainly weak after being ill, gastric abscess, dyspepsia, menoxenia, metrorrhagia, leukorrhagia, hematuria, hemorrhoidal bleeding.
Fructus Choerospondiatis: sweet is sour, flat.Promoting flow of QI and blood, nourishing blood to tranquillize the mind, removing food stagnancy, removing toxic substances.Cure mainly qi depression to blood stasis, chest pain, shortness of breath and palpitation, neurasthenia, insomnia, bronchitis, dyspepsia abdominal distention, diarrhoea, hernia, scald.
Juncus amplifolius A. Camus: flat, pungent, micro-hardship.Regulating QI to relieve pain, regulating menstruation and activating blood.Cure mainly stagnation of QI due to depression of the liver, pain in chest and hypochondrium, menoxenia, metrorrhagia leukorrhagia.
Radix Curcumae: pungent, bitter, cold, returns liver, gallbladder, heart channel.Promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clear away heart-fire removing heat from blood, promoting the function of the gallbladder to alleviate jaundice.Cure mainly the breast of qi depression to blood stasis, the side of body, stomachache; Calentura coma, epilepsy unconsciousness due to blockage of phlegm; Spit blood, epistaxis, vicarious menstruation, hematuria, stranguria with blood; Dampness-heat in the liver and gallbladder jaundice, cholelithiasis.
Radix Platycodonis: bitter, pungent, flat, returns lung meridian.Lung qi dispersing, eliminates the phlegm, sore-throat relieving, evacuation of pus.Cure mainly cough with copious phlegm, uncomfortable in chest not smooth; Laryngopharynx swelling and pain, aphonia; Lung abscess vomiting pus.
Radix Uncariae rhynchophyllae: sweet, bitter, is slightly cold.Relaxing muscles and tendons and activating QI and blood in the collateral, clearing heat for detumescence.Cure mainly arthragra, hemiplegia, depressive psychosis, infantile hyperpyrexia, edema, injury from falling down.
Caulis Lonicerae: sweet, cold, attaches to the lung and stomach meridians.Heat-clearing and toxic substances removing, dispelling wind and heat pathogens, removing obstruction in the collateral to relieve pain.Cure mainly epidemic febrile disease heating, beriberoid pyretic arthralgia, redness and swelling of joints burning pain, the diseases such as joint stuffiness.
Herba Passiflorae Caeruleae: bitter, warm.Dispel the wind, dehumidifying, invigorates blood circulation, pain relieving.Cure mainly headache due to common cold, wind-heat cough, Fengshi Guanjie arthralgia pain, colic, dysmenorrhea, insomnia.
Bombyx Batryticatus: salty, pungent, flat, returns liver, lung, stomach warp.Expelling wind for relieving convulsion, dissipating phlegm and resolving masses.
Cure mainly infantile convulsion to twitch; Wind apoplex involving the channels and collaterals, facial hemiparalysis; Headache due to pathogenic wind-heat, conjunctival congestion, pharyngalgia, rubella pruritus; Sucutaneous nodule, scrofula.
Herba Eupatorii Lindleyani: bitter, flat.Clearing away lung-heat to relieve cough, resolving phlegm and relieving asthma.Mainly treating bronchitis, cough with asthma excessive phlegm.
Fructus Viburni Ceanothoidis: sour, micro-sweet, flat.Heat-clearing and toxic substances removing, cough-relieving, hemostasis.Cure mainly cough, pneumonia, pertussis.
Cough variant asthma, without definite names of disease of tcm, according to its dry cough, few symptom such as expectorant, itching throat, and has the features such as chronic delay, obstinate refractory and recurrent exerbation, can belong to the different categories such as cough, chronic cough, lung-QI stagnation syndrome.Cough variant asthma pathogenesis is complicated, is commonly considered as caused by outer wind disturbance incubative pathogen (endogenous wind).But lung governing qi, has adjustment whole body mechanism of qi, promotes blood operation, the effects such as compress body fluid and regulating fluid apssage.With the passing of time, water liquid can not normal defeated cloth for pneumonopathy, poly-and be drink, then becomes expectorant; Disturbance of lung-QI, can not promote blood operation, so that stop in blood stasis.Visible, the stasis of blood, expectorant, wind (exogenous wind, endogenous wind) are the main pathological change of primary disease.The present invention adopts Radix seu Caulis Embeliae Parviflorae, Herba Limoii Bicoloris, Fructus Choerospondiatis nourishing blood and promoting blood circulation; Juncus amplifolius A. Camus, Radix Curcumae promoting QI circulation for relieving depression; Lung qi dispersing gas opened by Radix Platycodonis, and medicine carrying is up; Radix Uncariae rhynchophyllae, Caulis Lonicerae with the unimpeded venation of rattan class medicine, to increase the power of blood stasis dispelling; Herba Passiflorae Caeruleae expelling wind and removing dampness is to refuse exopathogen; Bombyx Batryticatus expelling wind for relieving convulsion, dissipating phlegm and resolving masses is with the endogenous wind that disappears; Herba Eupatorii Lindleyani, Fructus Viburni Ceanothoidis heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing.Above medicine is worked in coordination and is made blood lively atmosphere row, and lung network is fluent, and it is clear that wind puts out expectorant.Modern pharmacological research confirms, blood-activating stasis-removing kind medicine has quickening micro-circulation flow rate, makes the depolymerization of cohesion erythrocyte, thus improves microcirculatory effect; And can suppress fibrinogenic and ooze out and solidify, strengthen the vigor of cytophagous function and reticuloendothelial cell, suppress inflammatory reaction.
Preferably, the Chinese medicine preparation of described treatment cough variant asthma is made up of the crude drug of following mass ratio: Radix seu Caulis Embeliae Parviflorae 18 ~ 22 parts, Herba Limoii Bicoloris 23 ~ 27 parts, Fructus Choerospondiatis 35 ~ 45 parts, Juncus amplifolius A. Camus 5 ~ 7 parts, Radix Curcumae 8 ~ 10 parts, Radix Platycodonis 7 ~ 9 parts, Radix Uncariae rhynchophyllae 25 ~ 35 parts, Caulis Lonicerae 15 ~ 25 parts, Herba Passiflorae Caeruleae 13 ~ 17 parts, Bombyx Batryticatus 7 ~ 9 parts, Herba Eupatorii Lindleyani 35 ~ 45 parts, Fructus Viburni Ceanothoidis 11 ~ 13 parts.
Preferred further, the Chinese medicine preparation of described treatment cough variant asthma is made up of the crude drug of following mass ratio: Radix seu Caulis Embeliae Parviflorae 20 parts, Herba Limoii Bicoloris 25 parts, Fructus Choerospondiatis 40 parts, Juncus amplifolius A. Camus 6 parts, Radix Curcumae 9 parts, Radix Platycodonis 8 parts, Radix Uncariae rhynchophyllae 30 parts, Caulis Lonicerae 20 parts, Herba Passiflorae Caeruleae 15 parts, Bombyx Batryticatus 8 parts, Herba Eupatorii Lindleyani 40 parts, Fructus Viburni Ceanothoidis 12 parts.
The Chinese medicine preparation of described treatment cough variant asthma can adopt existing Chinese medicine preparation technology to be prepared into any conventional oral preparations, such as can decocting be adopted to obtain water decoction said components, by other existing Chinese medicine preparation technology, the Chinese medicine preparation of described treatment cough variant asthma can also be prepared into tablet, water-honeyed pill, capsule, powder, unguentum, oral liquid, granule.
compared with prior art, beneficial effect of the present invention
Chinese medicine preparation treatment cough variant asthma provided by the invention has evident in efficacy, has no side effect, the advantages such as patient compliance is good.
treat a Chinese medicine preparation for cough variant asthma, clinical efficacy is summed up
1 physical data
36 routine patients, wherein man 22 example, female 14 example, 18 ~ 67 years old age, the mean age (37.2 ± 10.6) year, the course of disease the shortest March, the longest 5 years.
2 diagnostic criterias
" the Clinics and Practices guide of cough " formulated with reference to respirology branch of Chinese Medical Association asthma group in 2009 [respirology branch of Chinese Medical Association asthma group. the Clinics and Practices guide (2009 editions) of cough. Chinese tuberculosis and breathe magazine, 2009,32 (6): 408-409.] diagnostic criteria of cough variant asthma in: 1. chronic cough (course of disease is greater than 8 weeks), often with obvious irritable cough at night; 2. brinchial provocation test is positive, or End--tidal PCO_2 aberration rate > 20% in the daytime, or Bronchodilation Test is positive; 3. antibiotic, cough suppressing medicine are invalid, and bronchodilators treatment effectively; 4. the chronic cough that other reasons causes is got rid of.
3 Therapeutic Method
Radix seu Caulis Embeliae Parviflorae 20 grams, Herba Limoii Bicoloris 25 grams, Fructus Choerospondiatis 40 grams, Juncus amplifolius A. Camus 6 grams, Radix Curcumae 9 grams, Radix Platycodonis 8 grams, Radix Uncariae rhynchophyllae 30 grams, Caulis Lonicerae 20 grams, Herba Passiflorae Caeruleae 15 grams, Bombyx Batryticatus 8 grams, Herba Eupatorii Lindleyani 40 grams, Fructus Viburni Ceanothoidis 12 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
4 therapeutic outcomes
4.1 efficacy assessment standards: reference " new Chinese medicine guideline of clinical investigations " (Ministry of Health of the People's Republic of China. new Chinese medicine guideline of clinical investigations. Beijing: China Medical Science Press, 2002,58.) standard envisages: clinical cure: clinical symptoms, sign disappear or substantially disappear, syndrome integral reduces >=95%; Effective: clinical symptoms, sign are obviously improved, syndrome integral reduces >=70%; Effective: clinical symptoms, sign all take a favorable turn, syndrome integral reduces >=30%; Invalid: clinical symptoms, sign are all not improved, even increase the weight of, syndrome integral reduces less than 30%.Integration × 100% before therapeutic index=(before treatment the rear integration of integration-treatment)/treatment.
4.2 results: through treatment in 4 weeks, clinical cure 10 example, effective 13 examples, effective 9 examples, invalid 4 examples, total effective rate 88.9%.
5 model cases
Lee, man, 16 years old.More than cough recurrent exerbation March, cough based on night or early morning, expectorant is few.Once repeatedly at certain hospital's Western medicine infection and symptomatic treatment, symptom was without improvement.Its mother, elder sister have allergic rhinitis medical history.Have a medical check-up: vital sign is without exception, cardiopulmonary are without exception; Tuberculin test (-), three is large conventional normal, and chest positive X sheet is without exception.Diagnosis: cough variant asthma.Oral Chinese medicine composition water decoction provided by the invention, transference cure of coughing after treatment in 4 weeks, follows up a case by regular visits to 1 year without outbreak.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
Embodiment 1
A kind of Chinese medicine preparation for the treatment of cough variant asthma, by Radix seu Caulis Embeliae Parviflorae 25 grams, Herba Limoii Bicoloris 30 grams, Fructus Choerospondiatis 50 grams, Juncus amplifolius A. Camus 9 grams, Radix Curcumae 12 grams, Radix Platycodonis l0 gram, Radix Uncariae rhynchophyllae 40 grams, Caulis Lonicerae 30 grams, Herba Passiflorae Caeruleae 20 grams, Bombyx Batryticatus 10 grams, Herba Eupatorii Lindleyani 50 grams, Fructus Viburni Ceanothoidis 15 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Embodiment 2
A kind of Chinese medicine preparation for the treatment of cough variant asthma, by Radix seu Caulis Embeliae Parviflorae 22 grams, Herba Limoii Bicoloris 27 grams, Fructus Choerospondiatis 45 grams, Juncus amplifolius A. Camus 7 grams, Radix Curcumae 10 grams, Radix Platycodonis 9 grams, Radix Uncariae rhynchophyllae 35 grams, Caulis Lonicerae 25 grams, Herba Passiflorae Caeruleae 17 grams, Bombyx Batryticatus 9 grams, Herba Eupatorii Lindleyani 45 grams, Fructus Viburni Ceanothoidis 13 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Embodiment 3
A kind of Chinese medicine preparation for the treatment of cough variant asthma, by Radix seu Caulis Embeliae Parviflorae 20 grams, Herba Limoii Bicoloris 25 grams, Fructus Choerospondiatis 40 grams, Juncus amplifolius A. Camus 6 grams, Radix Curcumae 9 grams, Radix Platycodonis 8 grams, Radix Uncariae rhynchophyllae 30 grams, Caulis Lonicerae 20 grams, Herba Passiflorae Caeruleae 15 grams, Bombyx Batryticatus 8 grams, Herba Eupatorii Lindleyani 40 grams, Fructus Viburni Ceanothoidis 12 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Embodiment 4
A kind of Chinese medicine preparation for the treatment of cough variant asthma, by Radix seu Caulis Embeliae Parviflorae 18 grams, Herba Limoii Bicoloris 23 grams, Fructus Choerospondiatis 35 grams, Juncus amplifolius A. Camus 5 grams, Radix Curcumae 8 grams, Radix Platycodonis 7 grams, Radix Uncariae rhynchophyllae 25 grams, Caulis Lonicerae 15 grams, Herba Passiflorae Caeruleae 13 grams, Bombyx Batryticatus 7 grams, Herba Eupatorii Lindleyani 35 grams, Fructus Viburni Ceanothoidis 11 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Embodiment 5
A kind of Chinese medicine preparation for the treatment of cough variant asthma, by Radix seu Caulis Embeliae Parviflorae 15 grams, Herba Limoii Bicoloris 20 grams, Fructus Choerospondiatis 30 grams, Juncus amplifolius A. Camus 3 grams, Radix Curcumae 6 grams, Radix Platycodonis 6 grams, Radix Uncariae rhynchophyllae 20 grams, Caulis Lonicerae 10 grams, Herba Passiflorae Caeruleae 10 grams, Bombyx Batryticatus 6 grams, Herba Eupatorii Lindleyani 30 grams, Fructus Viburni Ceanothoidis 9 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Claims (4)
1. treat a Chinese medicine preparation for cough variant asthma, it is characterized in that being made up of the crude drug of following mass ratio:
Radix seu Caulis Embeliae Parviflorae 15 ~ 25 parts, Herba Limoii Bicoloris 20 ~ 30 parts, Fructus Choerospondiatis 30 ~ 50 parts, Juncus amplifolius A. Camus 3 ~ 9 parts, Radix Curcumae 6 ~ 12 parts, Radix Platycodonis 6 ~ l0 part, Radix Uncariae rhynchophyllae 20 ~ 40 parts, Caulis Lonicerae 10 ~ 30 parts, Herba Passiflorae Caeruleae 10 ~ 20 parts, Bombyx Batryticatus 6 ~ 10 parts, Herba Eupatorii Lindleyani 30 ~ 50 parts, Fructus Viburni Ceanothoidis 9 ~ 15 parts.
2. the Chinese medicine preparation for the treatment of cough variant asthma as claimed in claim 1, is characterized in that being made up of the crude drug of following mass ratio:
Radix seu Caulis Embeliae Parviflorae 18 ~ 22 parts, Herba Limoii Bicoloris 23 ~ 27 parts, Fructus Choerospondiatis 35 ~ 45 parts, Juncus amplifolius A. Camus 5 ~ 7 parts, Radix Curcumae 8 ~ 10 parts, Radix Platycodonis 7 ~ 9 parts, Radix Uncariae rhynchophyllae 25 ~ 35 parts, Caulis Lonicerae 15 ~ 25 parts, Herba Passiflorae Caeruleae 13 ~ 17 parts, Bombyx Batryticatus 7 ~ 9 parts, Herba Eupatorii Lindleyani 35 ~ 45 parts, Fructus Viburni Ceanothoidis 11 ~ 13 parts.
3. the Chinese medicine preparation for the treatment of cough variant asthma as claimed in claim 1, is characterized in that being made up of the crude drug of following mass ratio:
Radix seu Caulis Embeliae Parviflorae 20 parts, Herba Limoii Bicoloris 25 parts, Fructus Choerospondiatis 40 parts, Juncus amplifolius A. Camus 6 parts, Radix Curcumae 9 parts, Radix Platycodonis 8 parts, Radix Uncariae rhynchophyllae 30 parts, Caulis Lonicerae 20 parts, Herba Passiflorae Caeruleae 15 parts, Bombyx Batryticatus 8 parts, Herba Eupatorii Lindleyani 40 parts, Fructus Viburni Ceanothoidis 12 parts.
4. treat the preparation method of the Chinese medicine preparation of cough variant asthma as claimed in claim 1, it is characterized in that the Chinese medicinal components of described mass ratio to be prepared into water decoction, tablet, water-honeyed pill, capsule, powder, unguentum, oral liquid, granule.
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CN104906472A (en) * | 2014-03-13 | 2015-09-16 | 刘黎明 | Traditional Chinese medicine composition for preventing and treating cough-variant asthma |
CN103990025A (en) * | 2014-06-17 | 2014-08-20 | 刘青振 | Traditional Chinese medicine for treating children cough variant asthma and preparation method of traditional Chinese medicine |
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