CN111870658A - Traditional Chinese medicine formula for treating chronic cough variant asthma of elderly patients and preparation method - Google Patents

Abstract

The invention relates to a traditional Chinese medicine formula for treating chronic cough variant asthma of an elderly patient and a preparation method thereof, wherein the formula comprises the following components: bitter apricot seed, mulberry leaf, thunberg fritillary bulb, aster, rhizoma pinellinae praeparata, salvia miltiorrhiza, dried orange peel, flos farfarae, fried spina date seed, radix pseudostellariae, radix ophiopogonis, schisandra chinensis, snakegourd fruit, poria with hostwood, Chinese yam, platycodon grandiflorum, bamboo shavings, stiff silkworm, cicada slough, liquorice and lactose. The traditional Chinese medicine formula particles for treating the chronic cough variant asthma of the elderly patients are elaborately developed according to the traditional Chinese medicine formula and the preparation principle, and the effective components are extracted according to the modern traditional Chinese medicine extraction technology, so that the traditional Chinese medicine formula particles have the advantages of strong pertinence, good curative effect, short period and no toxic or side effect, can quickly relieve the clinical symptoms of the patients, shortens the treatment course of the patients, is not easy to relapse, saves time and cost, and reduces the death rate.

Description

Traditional Chinese medicine formula for treating chronic cough variant asthma of elderly patients and preparation method

Technical Field

The invention relates to a traditional Chinese medicine composition, and in particular relates to a traditional Chinese medicine formula for treating chronic cough variant asthma of an elderly patient and a preparation method thereof.

Background

Cough asthma is a special type of cough variant asthma, and chronic cough is taken as a main clinical manifestation, and the course of disease lasts for more than 4 weeks or even years. The elderly patients are special population with cough asthma, because the immunity and the resistance to diseases of the elderly are far inferior to those of young people, the elderly patients are easy to be misdiagnosed as infectious diseases due to atypical clinical symptoms, and abuse of antibiotics is caused; in turn, abuse of antibiotics can lead to progression of lung disease; if the basic diseases such as hypertension and coronary heart disease are combined, the condition of the old can be more complicated and changeable, and the death rate is increased finally.

Western medicine considers that the disease is caused by interaction of various inflammatory mediators, inflammatory cells and cytokines. In addition, it also includes various factors such as nerve factor, immunity factor, infection factor and genetic factor. Clinically, chronic cough is the main or only symptom, and the cough is usually irritant dry cough with or without a small amount of sticky phlegm, the cough frequency or degree is aggravated at night, and no obvious urgency or asthma exists, but the cough has airway hyperreactivity. In traditional Chinese medicine, the disease is mostly classified into 'asthma' or 'chronic cough', and most doctors think that the pathogenesis of the disease is wind pathogen, and the lung fails to disperse, descend and descend; the cough variant asthma has the clinical characteristics of acute attack, rapid transmission, easy relapse and the like, and is not in conflict with the characteristic of the wind pathogen which is good at going and changes frequently. Wind is the long cause of many diseases and is easy to be accompanied by cold, summer-heat, dampness, dryness, fire and other pathogens; long-term pathogenic wind, which is apt to transform heat into fire and damage body fluids; so the old patients have a long course of disease, and the deficiency of lung qi and the disturbance of dry phlegm to the lung are caused; wind-pathogen determines the progress and prognosis of the disease during the development of the disease, and aggravates the disease course.

At present, the traditional Chinese medicine for treating the senile cough variant asthma (qi deficiency and chronic cough) does not exist, in clinic, hormones, antibiotics and asthma-relieving western medicines or combined cough-relieving and phlegm-reducing traditional Chinese medicines are mostly adopted, the treatment course is long, the condition is prolonged and difficult to cure, the progress of the condition is caused, and the western medicines can generate inevitable side effects after long-term use, so that the disease is easy to repeatedly occur.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine formula for treating chronic cough variant asthma of an elderly patient and a preparation method thereof, and overcomes the defect that no traditional Chinese medicine formula for treating cough variant asthma (qi deficiency chronic cough) is clear at present.

The technical scheme adopted by the invention is as follows:

the traditional Chinese medicine formula for treating the chronic cough variant asthma of the elderly patients is characterized in that:

the formula comprises the following components:

bitter apricot seed, mulberry leaf, thunberg fritillary bulb, aster, rhizoma pinellinae praeparata, salvia miltiorrhiza, dried orange peel, flos farfarae, fried spina date seed, radix pseudostellariae, radix ophiopogonis, schisandra chinensis, snakegourd fruit, poria with hostwood, Chinese yam, platycodon grandiflorum, bamboo shavings, stiff silkworm, cicada slough, liquorice and lactose.

The formula comprises the following components:

6-10 g of bitter almond, 9-12 g of mulberry leaf, 6-9 g of thunberg fritillary bulb, 9-12 g of aster, 6-9 g of rhizoma pinellinae praeparata, 10-30 g of salvia miltiorrhiza, 9-12 g of dried orange peel, 9-12 g of tussilago farfarfara, 10-15 g of fried spina date seed, 12-15 g of radix pseudostellariae, 9-12 g of radix ophiopogonis, 12-18 g of schisandra chinensis, 9-12 g of trichosanthes kirilowii maxim, 12-15 g of poria with hostwood, 15-30 g of Chinese yam, 9-12 g of platycodon grandiflorum, 12-15 g of bamboo shavings, 9-12 g of stiff silkworm, 6-9 g of periostracum cica.

The formula comprises the following components:

9g of bitter almond, 12g of mulberry leaf, 9g of thunberg fritillary bulb, 10g of aster, 9g of rhizoma pinellinae praeparata, 30g of salvia miltiorrhiza, 12g of dried orange peel, 10g of common coltsfoot flower, 15g of fried spina date seed, 15g of radix pseudostellariae, 9g of dwarf lilyturf tuber, 18g of Chinese magnoliavine fruit, 10g of snakegourd fruit, 15g of poria with hostwood, 30g of Chinese yam, 10g of platycodon grandiflorum, 12g of bamboo shavings, 9g of stiff silkworm, 9 g.

The formula comprises the following components:

8g of bitter almond, 10g of mulberry leaf, 7g of thunberg fritillary bulb, 10g of aster, 7g of rhizoma pinellinae praeparata, 20g of salvia miltiorrhiza, 10g of dried orange peel, 10g of common coltsfoot flower, 12g of fried spina date seed, 13g of radix pseudostellariae, 10g of dwarf lilyturf tuber, 15g of Chinese magnoliavine fruit, 10g of snakegourd fruit, 13g of poria with hostwood, 22g of Chinese yam, 10g of platycodon grandiflorum, 13g of bamboo shavings, 10g of stiff silkworm, 7g of cicada slou.

The formula is prepared into granules.

The preparation method of the traditional Chinese medicine for treating the chronic cough variant asthma of the elderly patient is characterized by comprising the following steps:

the traditional Chinese medicine dosage form is granules, and the preparation method comprises the following steps:

decocting all the components in water twice, each for 2 hr, filtering, mixing filtrates, concentrating, adding ethanol, standing, filtering, recovering ethanol from filtrate, standing, filtering, concentrating under reduced pressure to obtain soft extract, granulating, and drying.

Ethanol was added to make the alcohol content 50%.

The relative density of the thick paste obtained by decompression concentration is 1.30-1.35, and the temperature is 60-70 ℃.

Adding sucrose as required after obtaining thick paste, and mixing well.

The invention has the following advantages:

the traditional Chinese medicine formula granules for treating the chronic cough variant asthma of the elderly patients are elaborately developed according to the traditional Chinese medicine formula and the preparation principle, and the effective components are extracted according to the modern traditional Chinese medicine extraction technology, so that the traditional Chinese medicine formula granules have the advantages of strong pertinence, good curative effect, short period and no toxic or side effect, can quickly relieve the clinical symptoms of the patients, shorten the treatment course of the patients, prevent relapse, save time and cost and reduce the death rate.

Detailed Description

The present invention will be described in detail with reference to specific embodiments.

The invention relates to a traditional Chinese medicine formula for treating chronic cough variant asthma of an elderly patient, which comprises the following components: bitter apricot seed, mulberry leaf, thunberg fritillary bulb, aster, rhizoma pinellinae praeparata, salvia miltiorrhiza, dried orange peel, flos farfarae, fried spina date seed, radix pseudostellariae, radix ophiopogonis, schisandra chinensis, snakegourd fruit, poria with hostwood, Chinese yam, platycodon grandiflorum, bamboo shavings, stiff silkworm, cicada slough, liquorice and lactose.

The specific mixture ratio of the formula is as follows:

6-10 g of bitter almond, 9-12 g of mulberry leaf, 6-9 g of thunberg fritillary bulb, 9-12 g of aster, 6-9 g of rhizoma pinellinae praeparata, 10-30 g of salvia miltiorrhiza, 9-12 g of dried orange peel, 9-12 g of tussilago farfarfara, 10-15 g of fried spina date seed, 12-15 g of radix pseudostellariae, 9-12 g of radix ophiopogonis, 12-18 g of schisandra chinensis, 9-12 g of trichosanthes kirilowii maxim, 12-15 g of poria with hostwood, 15-30 g of Chinese yam, 9-12 g of platycodon grandiflorum, 12-15 g of bamboo shavings, 9-12 g of stiff silkworm, 6-9 g of periostracum cica.

The formula I is as follows:

9g of bitter almond, 12g of mulberry leaf, 9g of thunberg fritillary bulb, 10g of aster, 9g of rhizoma pinellinae praeparata, 30g of salvia miltiorrhiza, 12g of dried orange peel, 10g of common coltsfoot flower, 15g of fried spina date seed, 15g of radix pseudostellariae, 9g of dwarf lilyturf tuber, 18g of Chinese magnoliavine fruit, 10g of snakegourd fruit, 15g of poria with hostwood, 30g of Chinese yam, 10g of platycodon grandiflorum, 12g of bamboo shavings, 9g of stiff silkworm, 9 g.

As in formulation 2:

8g of bitter almond, 10g of mulberry leaf, 7g of thunberg fritillary bulb, 10g of aster, 7g of rhizoma pinellinae praeparata, 20g of salvia miltiorrhiza, 10g of dried orange peel, 10g of common coltsfoot flower, 12g of fried spina date seed, 13g of radix pseudostellariae, 10g of dwarf lilyturf tuber, 15g of Chinese magnoliavine fruit, 10g of snakegourd fruit, 13g of poria with hostwood, 22g of Chinese yam, 10g of platycodon grandiflorum, 13g of bamboo shavings, 10g of stiff silkworm, 7g of cicada slou.

The formulation can be prepared into granules, but is not limited to the formulation, and other formulations with mature preparation methods are also within the protection scope of the invention.

A preparation method of a traditional Chinese medicine for treating chronic cough variant asthma of an elderly patient comprises the following steps of:

decocting all the components in water twice, each for 2 hr, filtering, mixing filtrates, concentrating, adding ethanol, standing, filtering, recovering ethanol from filtrate, standing, filtering, concentrating under reduced pressure to obtain soft extract, granulating, and drying.

The method comprises the following steps:

adding ethanol to make ethanol content 50%;

the relative density of the thick paste concentrated under reduced pressure is 1.30-1.35, and the temperature is 60-70 ℃;

adding sucrose as required after obtaining thick paste, and mixing well.

The formula provided by the invention has the following characteristics:

1. the prescription is based on pulse-activating powder according to qi deficiency and chronic cough of old patients, and comprises radix pseudostellariae, radix ophiopogonis and schisandra chinensis, wherein: the fried spina date seed, the poria with hostwood, the snakegourd fruit and the platycodon root are compatible with the conventional cough medicine and are not commonly used; aiming at the obvious characteristics of cough at night, the wild jujube seeds and the poria with hostwood which are fried by tranquilizer are specially added, and the synergistic effect is achieved by combining the snakegourd fruit and the platycodon root which have the effects of relieving chest stuffiness and regulating qi.

2. Compared with similar applicable symptoms, the chronic cough variant asthma of the old patient has the advantages of being easy to relapse, unclear in induction reason and mainly caused by immune factors; therefore, aiming at the characteristic, the insect medicaments of the stiff silkworm and the cicada slough are specially added, and a large number of experimental researches prove that the insect medicaments have the effect similar to an immunomodulator; therefore, the insect drugs are specially added for the patients, and the recurrence rate of the disease is reduced. While for other types of coughing, this drug is not suitable.

3. The formula takes qi deficiency and chronic cough of old patients as main differentiation key points, takes pulse-activating powder and mulberry-apricot soup as base formulas, is specially matched with nerve-soothing medicines, chest-soothing and qi-regulating medicines, blood-activating and spleen-tonifying medicines and worm medicines, and summarizes all clinical manifestations of the cough comprehensively. The clinical observation can play a better role.

The prescription of the invention is precise and exquisite in compatibility aiming at the characteristics of patients with qi deficiency and chronic cough, has obvious curative effect on chronic cough variant asthma (qi deficiency and chronic cough) types of old patients through a large number of clinical verifications, has no obvious toxic or side effect, and has the advantages of short treatment course, quick response and effective rate of over 90 percent.

Example (b):

1. case selection:

the western medicine diagnosis conforms to the diagnosis standard of cough variant asthma in the ninth edition of internal medicine in 2018, and the traditional Chinese medicine diagnosis standard conforms to the diagnosis standard of dryness-syndrome lung in the traditional Chinese medicine disease diagnosis curative effect standard released by the State administration of traditional Chinese medicine in 2002. The clinical symptoms are: cough is mainly dry cough, no or little phlegm, white phlegm, thin and foamy texture, chronic cough, short breath, hypodynamia, pale or white complexion, pale red tongue with red or white coating, and thready and smooth pulse.

100 patients with age of 60-80 years were selected and randomized into 2 treatment groups of 50 patients each with no significant difference in samples.

2. The treatment method comprises the following steps: the two treatment groups both adopt the traditional Chinese medicine formula granules, and the using method comprises the following steps: taking the above formula granule, 15g, soaking in water for drinking, 3 times per day.

The traditional Chinese medicine formula is as follows: 9g of bitter almond, 12g of mulberry leaf, 9g of thunberg fritillary bulb, 10g of aster, 9g of rhizoma pinellinae praeparata, 30g of salvia miltiorrhiza, 12g of dried orange peel, 10g of common coltsfoot flower, 15g of fried spina date seed, 15g of radix pseudostellariae, 9g of dwarf lilyturf tuber, 18g of Chinese magnoliavine fruit, 10g of snakegourd fruit, 15g of poria with hostwood, 30g of Chinese yam, 10g of platycodon grandiflorum, 12g of bamboo shavings, 9g of stiff silkworm, 9 g.

3. The therapeutic effect judgment standard is as follows: refer to the diagnosis and treatment guidelines for common diseases in internal medicine of traditional Chinese medicine

Clinical cure: light cough occasionally occurs, but can be relieved without administration;

the effect is shown: the clinical symptoms are obviously relieved, and the cough still has regular attack but the times are obviously reduced;

the method has the following advantages: cough still has attacks, but the number of times is relatively reduced;

and (4) invalidation: there was no reduction in the number of cough episodes or even an exacerbation of clinical symptoms.

4. As a result:

after a treatment course, the results are evaluated according to the curative effect judgment standard, and the statistical result and the total effective rate are as follows:

as can be seen from the above table, the examples have significant effects on the chronic cough variant asthma (qi deficiency chronic cough) of the elderly patients, and the effective rate reaches over 90%.

The invention is not limited to the examples, and any equivalent changes to the technical solution of the invention by a person skilled in the art after reading the description of the invention are covered by the claims of the invention.

Claims (9)

1. The traditional Chinese medicine formula for treating the chronic cough variant asthma of the elderly patients is characterized in that:

the formula comprises the following components:

bitter apricot seed, mulberry leaf, thunberg fritillary bulb, aster, rhizoma pinellinae praeparata, salvia miltiorrhiza, dried orange peel, flos farfarae, fried spina date seed, radix pseudostellariae, radix ophiopogonis, schisandra chinensis, snakegourd fruit, poria with hostwood, Chinese yam, platycodon grandiflorum, bamboo shavings, stiff silkworm, cicada slough, liquorice and lactose.

2. The traditional Chinese medicine formula for treating chronic cough variant asthma in elderly patients according to claim 1, wherein:

the formula comprises the following components:

6-10 g of bitter almond, 9-12 g of mulberry leaf, 6-9 g of thunberg fritillary bulb, 9-12 g of aster, 6-9 g of rhizoma pinellinae praeparata, 10-30 g of salvia miltiorrhiza, 9-12 g of dried orange peel, 9-12 g of tussilago farfarfara, 10-15 g of fried spina date seed, 12-15 g of radix pseudostellariae, 9-12 g of radix ophiopogonis, 12-18 g of schisandra chinensis, 9-12 g of trichosanthes kirilowii maxim, 12-15 g of poria with hostwood, 15-30 g of Chinese yam, 9-12 g of platycodon grandiflorum, 12-15 g of bamboo shavings, 9-12 g of stiff silkworm, 6-9 g of periostracum cica.

3. The traditional Chinese medicine formula for treating chronic cough variant asthma in elderly patients according to claim 2, wherein:

the formula comprises the following components:

9g of bitter almond, 12g of mulberry leaf, 9g of thunberg fritillary bulb, 10g of aster, 9g of rhizoma pinellinae praeparata, 30g of salvia miltiorrhiza, 12g of dried orange peel, 10g of common coltsfoot flower, 15g of fried spina date seed, 15g of radix pseudostellariae, 9g of dwarf lilyturf tuber, 18g of Chinese magnoliavine fruit, 10g of snakegourd fruit, 15g of poria with hostwood, 30g of Chinese yam, 10g of platycodon grandiflorum, 12g of bamboo shavings, 9g of stiff silkworm, 9 g.

4. The traditional Chinese medicine formula for treating chronic cough variant asthma in elderly patients according to claim 2, wherein:

the formula comprises the following components:

8g of bitter almond, 10g of mulberry leaf, 7g of thunberg fritillary bulb, 10g of aster, 7g of rhizoma pinellinae praeparata, 20g of salvia miltiorrhiza, 10g of dried orange peel, 10g of common coltsfoot flower, 12g of fried spina date seed, 13g of radix pseudostellariae, 10g of dwarf lilyturf tuber, 15g of Chinese magnoliavine fruit, 10g of snakegourd fruit, 13g of poria with hostwood, 22g of Chinese yam, 10g of platycodon grandiflorum, 13g of bamboo shavings, 10g of stiff silkworm, 7g of cicada slou.

5. The traditional Chinese medicine formulation for treating chronic cough variant asthma in an elderly patient according to claim 2, 3 or 4, wherein:

the formula is prepared into granules.

6. The preparation method of the traditional Chinese medicine for treating the chronic cough variant asthma of the elderly patient is characterized by comprising the following steps:

the traditional Chinese medicine dosage form is granules, and the preparation method comprises the following steps:

decocting all the components in water twice, each for 2 hr, filtering, mixing filtrates, concentrating, adding ethanol, standing, filtering, recovering ethanol from filtrate, standing, filtering, concentrating under reduced pressure to obtain soft extract, granulating, and drying.

7. The method for preparing a Chinese medicine for treating chronic cough variant asthma of an elderly patient according to claim 6, wherein the method comprises the following steps:

ethanol was added to make the alcohol content 50%.

8. The method for preparing a Chinese medicine for treating chronic cough variant asthma of an elderly patient according to claim 7, wherein the method comprises the following steps:

the relative density of the thick paste obtained by decompression concentration is 1.30-1.35, and the temperature is 60-70 ℃.

9. The method for preparing a Chinese medicine for treating chronic cough variant asthma of an elderly patient according to claim 8, wherein the method comprises the following steps:

adding sucrose as required after obtaining thick paste, and mixing well.