CN107362311B

CN107362311B - Medicine 'Baicheqingjin' for treating cough

Info

Publication number: CN107362311B
Application number: CN201710739223.3A
Authority: CN
Inventors: 熊磊
Original assignee: Yunnan University of Traditional Chinese Medicine TCM
Current assignee: Yunnan University of Traditional Chinese Medicine TCM
Priority date: 2017-08-25
Filing date: 2017-08-25
Publication date: 2020-12-22
Anticipated expiration: 2037-08-25
Also published as: CN107362311A

Abstract

The invention relates to a myrobalan Qingjin granule for treating infantile cough, which comprises the following raw materials in percentage by weight: 4-30g of radix stemonae, 4-30g of myrobalan, 4-30g of fried scutellaria baicalensis, 4-30g of indigo naturalis, 4-30g of sea clam meal, 4-30g of honey-fried edestan, 4-30g of fried white mulberry root-bark, 4-30g of fried aster, 1-30g of oroxylum indicum, 4-30g of hairyvein agrimonia herb and bud, 4-30g of fried loquat leaf, 4-30g of dittany bark, 2-30g of cicada slough, 4-30g of cortex lycii radicis and 4-30g of almond. Starts from the aspects of changing the dosage form, improving the drug effect, enhancing the taste and the like, and is the myrobalan Qingjin granules which are convenient to take, safe and effective.

Description

Medicine 'Baicheqingjin' for treating cough

Technical Field

The invention relates to the field of traditional Chinese medicines, and in particular relates to a myrobalan Qingjin granule for treating infantile cough.

Background

Cough is generally caused by viral infection or mycoplasma, chlamydia infection. Research has shown that about 11% -25% of people suffer from subacute or even chronic cough, and in the epidemic season, the incidence rate of cough after infection can reach 25% -50%, so the disease is very common in pediatric respiratory diseases, and the incidence is in growing trend in recent years. However, the actual pathogenesis of cough after infection is still unclear, and satisfactory treatment is still lacked so far, so that doctors are easy to misdiagnose clinically or other complications are caused; although most children patients can be self-healed, the cough symptoms are stubborn and delayed in the process, and the physical and psychological health of the children patients is also seriously affected, so that unnecessary economic loss and psychological burden are caused, and therefore, the more effective method for treating the cough after the children are infected becomes urgent.

At present, according to the cough diagnosis and treatment guidelines (2009 edition) issued by the respiratory syndrome of the Chinese medical society, asthma group, β 2 receptor agonists (such as tylosin aerosol), glucocorticoid nebulization (such as dexamethasone and budesonide), antitussives (such as dextromethorphan) and the like are mostly selected for symptomatic treatment in western medicine, but the effect is not ideal, side effects such as sleepiness, dry mouth, nausea, constipation and the like may occur, few critically ill children need to inhale or take glucocorticoid to treat symptoms, but the symptoms can be relieved, and the symptoms are often repeated after the medicine is stopped, so that part of doctors unreasonably use antibiotics, which also becomes an important reason for the rise of bacterial drug resistance.

The traditional Chinese medicine has rich experience in treating cough and obvious advantages. Through retrieval, clinical research reports of treating post-infection cough by methods of dispelling wind, dispersing pathogen accumulation, freeing lung, relieving and strengthening body resistance and the like are common at present, but the research of the action mechanism of the traditional Chinese medicine aiming at the disease is rare, and the research of the action mechanism and the action target point still lacks experimental basis.

The invention relates to a formula which is distinguished from Jingyue quan Shu & cough and aims to overcome the defect that body fluid in lung is insufficient and withers and falls when cough happens, and the formula comprises radix stemonae, myrobalan, ephedra herb, cortex mori radicis, radix scutellariae, radix asteris, indigo naturalis, sea clam powder and cortex dictamni. In the formula, the stemona root is sweet, moist, bitter and descending, slightly warm and not dry, enters lung channels, has the effect of moistening lung to relieve cough, the myrobalan is sour, astringent and bitter, can lower energy, can astringe lung qi to relieve cough, can clear lung heat, relieve sore throat and produce sound, and the two medicines are used for moistening lung and astringing transverse reversed flow of liver qi; the ephedra herb is pungent, bitter and warm, has ascending and dispersing properties, the mulberry bark has sweet taste, is cold in nature and descends, can lower adverse qi in the lung and purge stagnated heat in the lung, and has the advantages of ascending, descending, immediate relief and moderate opening and closing; scutellariae radix, for clearing lung heat, eliminating phlegm, and relieving cough and asthma; natural indigo, for clearing liver fire and purging lung heat; haiha powder has the effects of lowering qi and reducing phlegm, and has the effects of moistening lung and reducing phlegm, clearing liver and relieving spasm, and lowering adverse qi and relieving cough with other medicines in a formula. However, the traditional decoction is time-consuming in decoction processing, bitter in taste, large in amount, inconvenient to take and poor in children compliance. Therefore, the invention starts with changing the formulation, improving the drug effect, enhancing the taste and the like, and develops the medicine terminalia fruit Qingjin granules which are convenient to take, safe and effective.

The relevant articles/academic papers and studies that have been published to date in connection with the present invention are based on the following:

[1] influence of Mingxi, Dingjun, Jiuyu Huayun, Wanyan, Xiongyizi, Bai Chebula Qingjin granules on airway inflammation of airway hyperreactivity rats [ J ] Sichuan TCM, 2017, (06):52-55.

[2] Study of clinical efficacy of Mingxi, Wangyan, Qianjiang, Urliu, Chenbojun, Baihe and Qingjin granules on cough after infection of wood fire criminal jin type children [ J ]. proceedings of Hubei university of traditional Chinese medicine 2016,01:51-53.

[3] Liu Rong, Xiu Lei, Xianju, Chen Baijun, Liu Dan, professor of Xiu Lei for treating cough variant asthma experience [ J ]. proceedings of Yunnan college of traditional Chinese medicine 2015,06:90-92.

[4] Liu Rong, Xiu Yi, Xiji Xuan, Wang Advance and Liu Dan summary of TCM treatment of infantile cough variant asthma [ J ] J of TCM pediatrics 2016,02:62-65.

[5] Pandai, li xiaoshan, wuwen, david 32741reed stem decoction, pediatric clinical application experience [ J ]. proceedings of the national academy of traditional Chinese medicine of Yunnan, 2008,05:34-36.

[6] Mingxi, Xiu Lei professor differentiation and treatment of children cough experience [ A ] Chinese medicine society of medicine, pediatrics division, national institute of education, advanced medicine, pediatrics teaching research, No. 24 th national institute of medicine, pediatrics teaching research compilation [ C ] Chinese medicine conference of medicine, pediatrics teaching research, and national institute of education, pediatrics teaching research, 2007:4.

[7] Bear Lei, Li Xiaoshan, He Wen, Dai \32741reedstem decoction, pediatric clinical application experience [ A ] Chinese traditional medicine society, pediatrics division, 25 th national Chinese traditional medicine pediatrics academic seminar and Chinese medicine advanced education, pediatrics teaching research conference, collection [ C ] Chinese traditional medicine society, pediatrics division, 2008:2.

[8] The experience of Yangbai, Xiu Lei Jia Feng ren physicians in treating children's cough is summarized [ J ]. J. TCM J. pediatrics, 2006,03:4-6.

[9] Bear epididymis, Li Xiaoshan, He Wen, three stages of treatment of cough syndrome in children, nine methods [ J ]. proceedings of Yunnan college of traditional Chinese medicine, 2005,03:41-43.

[10] Professor heavenly bear, Yunan academy of traditional Chinese medicine, 2005,01:47-48.

[11] Wangli, Xionglin, Erlingu soup uses ruminant [ J ]. proceedings of Yunnan academy of traditional Chinese medicine, 2004,01:23-24.

[12] Clinical observation of YI Wei Na, Yang Sha bang, Xiong Lei, Xuan Fei Zhi He mixture for treating wind-heat type exogenous cough in children [ J ]. proceedings of Yunnan college of traditional Chinese medicine, 2001,04:13-15.

[13] Xiongliu Yangpang Zhike ten methods introduction [ J ] Yunnan J.TCM 1997,04:13-14.

Disclosure of Invention

The inventor is engaged in the pediatric clinical and teaching work of traditional Chinese medicine for more than 30 years, the clinical effective proved formula of the hundred-myrobalam Qingjin decoction is based on the special clinical manifestations of cough, paroxysmal cough and irritable cough after children are infected, and after the children are chronically cough, the symptoms of liver channel fire hyperactivity such as strange sex, crying and screaming are often appeared, and the physiological and pathological characteristics of the children 'the liver is always surplus and the lung is always insufficient' are combined, so that the disease is considered to be marked with the pathogenesis of 'cough with adverse rising of qi', the diseased position is still in the lung but not separated from the liver, and the treatment should be based on 'clearing liver and relieving spasm, lowering adverse qi and relieving cough'. The Bai He QING JIN TANG has the functions of dispersing lung qi and eliminating phlegm, and clearing liver and lowering adverse qi, and is mainly used for treating cough and shortness of breath, excessive and sticky phlegm, difficult expectoration, yellow and thick color, red tongue with yellow and greasy coating, and rapid and wiry and smooth pulse.

The technical scheme of the invention is composed of 4-30g of honey-fried edestan, 4-30g of fried white mulberry root-bark, 4-30g of fried scutellaria baicalensis, 4-30g of fried aster, 4-30g of radix stemonae, 4-30g of myrobalan, 4-30g of indigo naturalis, 4-30g of sea clam meal, 4-30g of dittany bark, 4-30g of cicada slough, 4-30g of oroxylum indicum, 4-30g of hairyvein agrimonia herb and bud, 4-30g of fried loquat leaf, 4-30g of cortex lycii radicis and 4-30g of almond.

In the formula, the stemona root is sweet, moist, bitter and descended, enters lung channel, is warm but not dry, is good at moistening lung and relieving cough, can be used for treating external infection and internal injury, new cough, chronic cough and cold and heat, is an essential drug for treating chronic cough and deficiency cough, is sour, astringent, bitter and flat, enters lung and large intestine channels, can reduce energy, can astringe lung qi and relieve cough, can clear lung and relieve sore throat and produce sound, astringes intestines and stops diarrhea, and is particularly suitable for chronic cough, vomiting and vomiting with severe constipation; the two herbs are combined to moisten lung and astringe lung, astringe qi of lung and intestine, and mother and child are combined to be the monarch herbs. Bai Qin is bitter and cold in nature, mainly enters lung meridian and is good at clearing lung heat in upper energizer; indigo naturalis is salty in flavor and cold in nature, enters liver and lung meridians, and clears liver fire to purge lung heat; the sea clam powder is salty and cold in nature, clears away the lung-heat and reduces phlegm, eliminates stubborn phlegm and prevents chronic diseases, has pungent and slightly bitter taste and descending property, enters lung and bladder channels, can open the stasis of skin and hair outside to ensure that lung qi is smooth, pathogenic wind is dispersed from the exterior, can reduce the adverse qi in the interior, has the effect of relieving asthma by recovering the normal descending function of the lung, is an important medicine for mainly treating asthma and cough caused by the obstruction of the lung qi, has the sweet and cold taste of the white mulberry root-bark, mainly enters the lung channels, can clear lung fire and purge water and gas in the lung to relieve asthma, is used for clearing lung heat and purging liver fire to eliminate stubborn phlegm and regulating qi activity as ministerial medicines; aster tataricus is sweet, moist, bitter and lax, warm in nature but not hot, moist in nature but not dry, and good at moistening lung and descending qi, opening lung depression, resolving phlegm and turbidity and relieving cough; the Indian mockstrawberry herb is bitter, sweet and cool, enters lung channel, clears lung heat and relieves sore throat, soothes liver and harmonizes stomach, is hairyvein agrimony, is bitter, astringent and flat, can astringe and tonify deficiency, is bitter and slightly cold in loquat leaf taste, clears lung heat and relieves cough, relieves cough and asthma, strengthens the effects of clearing liver and purging fire, astringes lung and relieving cough, and is an adjuvant drug; the cortex dictamni is bitter in taste and cold in nature, clears heat and dries dampness, dispels wind and relieves itching, and the periostracum cicadae is sweet and cold in taste, dispels wind and dissipates heat, relieves sore throat and makes sound; cortex lycii radicis sweet and cold, can clear away lung heat and reduce deficient fire, and almond is bitter, slightly pungent and warm, can relieve cough and asthma, and can relax bowel; the above herbs are used as guiding herbs together, to dispel wind, relieve itching, moisten intestines, relieve constipation and make phlegm-fire out of the way. The formula has strict compatibility, combines the functions of clearing liver and moistening lung, and combines the functions of dispersing lung qi and lowering qi to play the effects of nourishing yin and moistening dryness, clearing liver and dispersing lung qi, dispersing lung qi and relieving cough, eliminating phlegm and moistening intestines. Clinical application proves that the cough-relieving traditional Chinese medicine composition has the advantages of rapid cough relieving, difficulty in relapse and less side effect. Particularly, after the cicada slough, the oroxylum indicum, the agrimony, the roasted loquat leaf, the cortex lycii radicis, the almond and other raw material medicines are added, the lung ventilating and cough relieving effects of the original formula can be enhanced, the stomach invigorating and deficiency tonifying effects are improved according to the characteristics of children, and a remarkable effect is obtained.

The invention aims to provide the myrobalan Qingjin granules which have remarkable effect and are used for treating infantile cough. The technical scheme is as follows:

the myrobalan Qingjin granules are characterized by comprising the following raw materials in parts by weight: 4-30g of radix stemonae, 4-30g of myrobalan, 4-30g of fried scutellaria baicalensis, 4-30g of indigo naturalis, 4-30g of sea clam meal, 4-30g of honey-fried edestan, 4-30g of fried white mulberry root-bark, 4-30g of fried aster, 1-30g of oroxylum indicum, 4-30g of hairyvein agrimonia herb and bud, 4-30g of fried loquat leaf, 4-30g of dittany bark, 2-30g of cicada slough, 4-30g of cortex lycii radicis and 4-30g of almond; the radix Stemonae is radix Stemonae or radix Stemonae processed with Mel.

Further preferably, the weight ratio of each component is as follows: 20-30g of radix stemonae, 20-30g of myrobalan, 15-25g of fried scutellaria baicalensis, 8-18g of indigo naturalis, 8-18g of sea clam meal, 15-25g of honey-fried edestan, 15-25g of fried white mulberry root-bark, 15-25g of fried aster, 3-25g of oroxylum indicum, 15-25g of hairyvein agrimonia herb and bud, 8-18g of fried loquat leaf, 8-18g of dittany bark, 5-18g of cicada slough, 5-15g of cortex lycii radicis and 5-15g of almond.

Further preferably, the weight ratio of each component is as follows: 25g of radix stemonae, 25g of myrobalan, 20g of fried scutellaria baicalensis, 10g of indigo naturalis, 10g of sea clam powder, 20g of honey-fried edestan, 20g of fried white mulberry root-bark, 20g of fried aster, 5g of oroxylum indicum, 20g of hairyvein agrimonia herb, 15g of fried loquat leaf, 10g of dittany bark, 10g of cicada slough, 10g of cortex lycii radicis and 10g of almond.

In particular, the efficacy of the drug is as follows:

radix Stemonae is sweet, moist, bitter and descending, warm and not dry, enters lung meridian, and has the special effect of moistening lung to arrest cough. Ming Yi Bie Lu (miscellaneous records of famous physicians) governing cough and ascending qi. The pottery and the potpourri are considered as' treating cough by processing wine stain with Bai fire and drinking. In addition, dust mite is a common and harmful allergen recognized globally, and radix stemonae has insecticidal efficacy and indirectly treats the disease. Modern researches show that radix stemonae contains various alkaloids, wherein the stemonine can reduce respiratory center excitation and has the effects of relieving cough, eliminating phlegm and relieving asthma. In addition, the 3, 5-dihydroxy-4-methyl biphenyl has the effects of inhibiting cancer cells, promoting various immune functions and antagonizing the effect of cyclophosphamide on reducing the immune function of the organism.

Myrobalan is bitter, sour and astringent in taste and neutral in nature. It enters lung and large intestine meridians. Has the functions of astringing lung, relieving cough, relieving sore throat and producing sound. Sour flavor enters liver, can astringe and descend, astringe lung and descend qi to relieve cough, clear liver and relieve sore throat to produce sound. It is used clinically in treating lung deficiency, dyspnea with cough, chronic cough, pharyngalgia, hoarseness and other diseases. The Ben Jing He Jie Yuan (the origin of Ben Jing meeting), unprocessed Qing jin Zhi Shu, stewed to strengthen the spleen to check diarrhea. Modern researches show that the myrobalan has spasmolytic effect on smooth muscle. The results of clinical strain bacteriostasis tests of 335 strains on the myrobalan decoction show that the myrobalan has good bacteriostasis to gram-positive cocci and 90% of bacteriostasis concentration to staphylococcus aureus, staphylococcus epidermidis, escherichia coli, pseudomonas aeruginosa and enterococcus faecalis.

Scutellaria baicalensis Georgi is dried root of Scutellaria baicalensis Georgi of Labiatae. Collected in spring and autumn, removed fibrous root and silt, dried in the sun, removed the rough skin, and dried in the sun. Clear heat and dry dampness, purge fire and remove toxicity, stop bleeding, prevent abortion. Can be used for treating chest distress, nausea, damp-heat, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.

Qing Dai is salty in flavor and cold in nature. It enters liver meridian. Has the functions of clearing liver-fire, clearing heat and detoxicating. Mainly clear liver fire and purge lung heat, it is commonly used for cough due to liver fire invading lung. The book Jing meets the former, it is said to purge liver and gallbladder and dispel stagnated fire. Modern researches have shown that indigo naturalis and indigo naturalis have antiviral and hepatoprotective effects. In addition, it has effects in dilating cardiovascular system, resisting hepatitis B virus, and resisting cancer.

Hai Ge fen is salty, cold in nature, non-toxic and natural by the yin qi in water. Decrease the rate. Yin is also involved. Those who are recorded in the sea. It is different from the generation of Jianghu and Di ze. Mainly heat-phlegm. Dampness-phlegm. Old phlegm. Stubborn phlegm. Hernia is caused. White turbidity. With leucorrhea. Enter heart and kidney meridians. It is a soft, hard and moist herb.

Ma Huang is pungent in flavor and warm in nature. It enters lung and bladder meridians. Has the functions of ventilating lung and relieving asthma. Can open the stasis of skin and hair to make the lung qi smooth and the pathogenic wind disperse; the ascending qi is descending, so that the lung governs descending. It excels at relieving dyspnea, and is the key herb for dyspnea and cough due to lung qi obstruction. Moxibustion Ma Huang has stronger action of moistening lung than raw Ma Huang. Shen nong Ben Cao Jing (Shen nong's herbal), where Ma Huang relieves cough and reverses the flow of qi upward. Modern researches have shown that ephedra mainly contains various components such as ephedrine, pseudoephedrine, methyl pseudoephedrine and the like. Ephedrine in the mix-fried ephedra has obvious relaxation effect on bronchial smooth muscle, and volatile oil of the mix-fried ephedra has strong inhibition effect on influenza virus; the ephedrine has long spasmolytic effect on bronchial smooth muscle, and especially has more remarkable effect when the bronchus is in a spastic state. The effects of ephedra such as asthma relieving, inflammation resisting, allergy resisting and the like are the pharmacological basis of freeing lung and relieving asthma.

Sang Bai Pi is sweet in flavor, cold in nature and descending, mainly enters lung meridian, and has the actions of purging lung fire, relieving asthma, inducing diuresis and relieving swelling. It can clear lung fire, purge water and qi in lung to relieve dyspnea, induce diuresis to alleviate edema to treat eye edema. The treatise on the lung-qi dyspnea with fullness and distention is published in the treatise on the property of herbs. The book of medical science: "purging excess of lung, not sang Pi". The miscellaneous records of famous physicians: it is used to eliminate lung water, stop saliva and blood, and to quench thirst and edema. Modern researches show that the acetone extract of the white mulberry root-bark has obvious effects of relieving cough and eliminating phlegm, and the inhibition effect of the processed honey-fried white mulberry root-bark water extract on the cough of mice caused by sulfur dioxide is obviously stronger than that of the raw white mulberry root-bark. The acetone extract has antiasthmatic effect by increasing the content of Nitric Oxide (NO) in trachea and relaxing smooth muscle of bronchus, and scopoletin (6-methoxy-7-hydroxy-coumarin) is considered as the effective antiasthmatic component of cortex Mori. In addition, it also has analgesic, antiinflammatory, immunity regulating, platelet aggregation inhibiting, blood vessel dilating, diuretic, and blood glucose lowering effects.

Tatarian aster root, radix Asteris, bitter in flavor and warm in nature. The functional indications are as follows: warm lung, descend qi, resolve phlegm and relieve cough. It is used to treat cough and asthma due to wind-cold evil, cough with pus and blood, throat impediment, and dysuria.

Qian Bing Wan is named as Mao Wan, because the wood is like hyacinth bean and big, the middle is like accumulated paper, the wood is like cicada's wing, and the pieces are full of the middle, it is named as Mao Ling Qian paper. Entering lung meridian, relieving asthma, and eliminating phlegm; enter the spleen and stomach meridians to break venomous food stagnation, circulate qi and blood of the twelve meridians to remove the toxic substances of venomous food and qi venomous food. It can also tonify deficiency, relieve epigastric distention and eat food. In the national region, the herb is called three hundred and two silver herbs, so it is also indicated for parasitic tympanties.

Herba et Gemma Agrimoniae has effects of invigorating stomach and tonifying deficiency. It is indicated for hemoptysis, hematemesis, hematuria, hematochezia, red and white dysentery, metrorrhagia and metrostaxis, leukorrhagia, traumatic injury, carbuncle and swelling, traumatic hemorrhage.

Loquat leaves can clear away lung-heat, relieve cough, harmonize stomach, check adverse rise of qi, and quench thirst. Lung heat with phlegm cough; cough due to yin deficiency; hemoptysis; bleeding; vomiturition due to stomach heat.

Cicada slough can dispel wind-heat, ventilate lung and relieve spasm. It is used to treat wind-heat common cold, cough, hoarseness, measles without adequate eruption, rubella, infantile convulsion, conjunctival congestion, nebula, furuncle, toxic swelling, and tetanus.

Cortex Lycii, being effective in clearing heat and cooling blood. It is used to treat tidal fever and night sweat due to asthenia, cough and asthma due to lung heat, hematemesis, epistaxis, stranguria with blood, diabetes, hypertension, carbuncle, swelling, and skin ulcer.

Semen Armeniacae amarum, dried seeds of bitter taste of Prunus Armeniaca or Prunus Armeniaca of Rosaceae. Picking in summer when fruit is mature, removing pulp and core shell, taking out kernel, and air drying. Placing in shady and dry place for preventing worm damage. Eliminating phlegm and relieving cough; relieving asthma; moistening intestines; descending qi and relieving arthralgia. Cough due to exogenous pathogenic factors; gasp and fullness; impairment by dryness with cough; cold running dolphin; fright epilepsy; chest stuffiness; epigastric pain due to food stagnation; metrorrhagia; deafness; malnutrition with swelling; stranguria due to damp-heat; scabies; pharyngitis; constipation due to intestinal dryness.

In conclusion, the myrobalan Qingjin formula is rigorous in prescription, exquisite in compatibility, and suitable for the physiological and pathological characteristics of 'more frequent liver and frequent insufficiency of lung' of children and the etiology of 'wind and adverse qi', is gentle and flexible in medication, and abandons a group of cold and cool drugs due to the trend of guiding, and is selected to ventilate lung and descend qi, clear liver and purge lung, and moisten lung and relieve cough. Therefore, the cough relieving effect is good, the recurrence is not easy, and the cough symptoms and accompanying symptoms of children with cough variant asthma can be obviously improved.

The preparation method of the myrobalan Qingjin granules comprises the following steps:

the fructus terminaliae Billericae Qingjin granules are prepared by decocting the medicinal materials in water twice, adding 4-10 times of water for the first time, adding 4-10 times of water for the second time, decocting for 1-4 hours each time, filtering, collecting filtrate, concentrating, drying, adding a proper amount of dextrin and sucrose, and preparing into granules.

The fructus terminaliae Billericae Qingjin granules are prepared by decocting the medicinal materials in water twice, adding 8 times of water for the first time, adding 6 times of water for the second time, decocting for 2 hours each time, filtering, collecting filtrate, concentrating, drying, adding a proper amount of dextrin and sucrose, and preparing into granules.

The myrobalan Qingjin granules are prepared by adding 95% ethanol into the medicinal materials for refluxing twice, adding 4-10 times of ethanol for the first time, adding 4-10 times of ethanol for the second time, wherein the refluxing time is 0.5-2 hours each time, filtering, collecting filtrate, concentrating, drying, adding a proper amount of dextrin and sucrose, and preparing into granules.

The myrobalan Qingjin granules are prepared by adding 95% ethanol into the medicinal materials for refluxing twice, adding 8 times of ethanol for the first time and 6 times of ethanol for the second time, wherein the refluxing time is 0.5-2 hours each time, filtering, collecting filtrate, concentrating, drying, adding a proper amount of dextrin and sucrose, and preparing into granules.

The fructus terminaliae Billericae Qingjin granules can be prepared into dosage forms of granules, paste, pills, oral liquid, pills, powder, dripping pills, capsules and the like according to actual needs.

Detailed Description

Example 1 preparation example of Terminalia Billerica Qingjin granules

Selecting raw material medicines of 20g of radix stemonae, 20g of myrobalan, 20g of fried scutellaria baicalensis, 10g of indigo naturalis, 10g of sea clam meal, 25g of honey-fried edestan, 25g of fried white mulberry root-bark, 20g of fried aster, 5g of oroxylum indicum, 20g of hairyvein agrimonia herb, 15g of fried loquat leaf, 10g of dittany bark, 10g of cicada slough, 10g of cortex lycii radicis and 10g of almond; decocting the above materials in water twice, adding 4-10 times of water for the first time, adding 4-10 times of water for the second time, decocting for 1-4 hr each time, filtering, collecting filtrate, concentrating, drying, adding appropriate amount of dextrin and sucrose, and making into granule.

Example 2 preparation example of Terminalia Billerica Qingjin granules

Selecting raw material medicines of 20g of radix stemonae, 20g of myrobalan, 20g of fried scutellaria baicalensis, 10g of indigo naturalis, 10g of sea clam meal, 25g of honey-fried edestan, 25g of fried white mulberry root-bark, 20g of fried aster, 5g of oroxylum indicum, 20g of hairyvein agrimonia herb, 15g of fried loquat leaf, 10g of dittany bark, 10g of cicada slough, 10g of cortex lycii radicis and 10g of almond; adding 8 times of water into the medicinal materials, refluxing for two times by using 50-95% ethanol, adding 8 times of ethanol for the first time, adding 6 times of ethanol for the second time, wherein the refluxing time is 0.5-2 hours each time, filtering, collecting filtrate, concentrating, drying, adding a proper amount of dextrin and sucrose, and preparing into granules.

Example 3 preparation example of Terminalia Billerica Qingjin granules

Selecting 30g of radix stemonae, 30g of myrobalan, 25g of fried scutellaria baicalensis, 8g of indigo naturalis, 8g of sea clam powder, 20g of honey-fried edestan, 20g of fried white mulberry root-bark, 15g of fried aster, 5g of oroxylum indicum, 15g of hairyvein agrimonia herb and bud, 20g of fried loquat leaf, 12g of dittany bark, 8g of cicada slough, 5g of cortex lycii radicis and 5g of almond as raw materials; decocting the above materials in water twice, adding 8 times of water for the first time and 8 times of water for the second time, decocting for 3 hr each time, filtering, collecting filtrate, concentrating, drying, adding appropriate amount of dextrin and sucrose, and making into granule.

EXAMPLE 4 efficacy test for treatment of infantile cough

150 children with cough variant asthma with liver-fire attacking lung meeting the inclusion criteria were randomly divided into 50 patients in each of the treatment group, control 1 group and control 2 group.

The oral medicine of fructus terminaliae bellericae and Qingjin granules is prepared according to the preparation method of the medicine in the embodiment 1.

Control 1 group was inhaled by combined nebulization of budesonide suspension and terbutaline sulfate nebulization solution.

The preparation method of the oral control granule for the control 2 groups comprises the following steps: 25g of radix stemonae, 25g of myrobalan, 20g of fried scutellaria baicalensis, 10g of indigo naturalis, 10g of hayata powder, 25g of honey-fried edestan, 25g of fried white mulberry root-bark, 20g of fried aster, 5g of oroxylum indicum, 20g of hairyvein agrimonia herb, 10g of cortex lycii radicis, 10g of almond and 5g of liquorice; decocting the above materials in water twice, adding 4-10 times of water for the first time, adding 4-10 times of water for the second time, decocting for 1-4 hr each time, filtering, collecting filtrate, concentrating, drying, adding appropriate amount of dextrin and sucrose, and making into granule.

Three groups were treated continuously for 14 days. Compared with the children patients in the treatment group and the control group, the differences in age, sex, disease course and the like have no statistical significance (P >0.05) and are comparable. The total effective rate of the treatment group is 92%, the total effective rate of the control group 1 is 86%, the total effective rate of the control group 2 is 84%, the total curative effect of the treatment group is better than that of the control group, and the difference has statistical significance (P is less than 0.05).

Example 5 Effect on airway inflammation in airway hyperresponsiveness rat

The purpose is as follows: observing the interference effect of the myrobalan qingjin granules on airway inflammation of the rat with airway hyperresponsiveness. The method comprises the following steps: randomly dividing 48 SD rats into a blank group, a model group, a dexamethasone group and a myrobalan gold-clearing granule low, medium and high dose groups, wherein each group comprises 8 rats; ovalbumin was used for sensitization, replicating the airway hyperreactivity rat model. Recording the total number and the classified count of the white blood cells in each group of bronchoalveolar lavage fluid (BALF) according to the experimental plan for dry prognosis; detecting the content of interleukin-4 (IL-4), interleukin-6 (IL-6), interferon-gamma (IFN-gamma) and tumor necrosis factor (TNF-alpha); and observing the pathological features of HE staining of lung tissues. As a result: the myrobalan Qingjin granules with high and medium dosage can obviously reduce the quantity of leucocytes, eosinophils (P is less than 0.001) and neutrophils (P is less than 0.05) in the BALF of the rat with high airway response, and reduce the inflammatory injury of lung tissues. Compared with the blank group, the model group has obviously increased IL-4, IL-6 and TNF-alpha levels (P < 0.001) and obviously reduced IFN-gamma levels (P < 0.001). The high-dose group can obviously reduce the expression of IL-4(P is less than 0.001), IL-6 and TNF-alpha (P is less than 0.01), and increase the level of IFN-gamma (P is less than 0.01), and the effect is equivalent to that of the nostoc; although the IL-4 and TNF-alpha levels in the medium and low dose groups are obviously lower than those in the model group, the difference has no statistical significance. And (4) conclusion: the fructus terminaliae billericae Qingjin granules can inhibit airway inflammatory reaction of rats with airway hyperresponsiveness, reduce airway hyperresponsiveness and have an obvious dose-effect relationship; this may be part of the mechanism of action for treating diseases with increased airway reactivity, such as cough after infection.

Specific experimental details can be found in published articles: mingxi et al, Bai He Qing jin granules influence on airway inflammation in rat with airway hyperresponsiveness, Sichuan TCM, 35 vol.6 th in 2017, page 52-55. The myrobalan Qingjin granules adopted in the method are the granules prepared in the example 1 of the invention.

Example 6 animal test for antitussive Effect

60 guinea pigs were randomly divided into 3 groups of 20 animals each. One week before the experiment, the stomach is perfused and administrated 2 times every day, each time the stomach is administrated 2mL/100g, the experiment is administrated 1 time on the day, 2 hours later, the guinea pig is placed into a spraying device, ammonia water is sprayed at a constant speed, the time from the spraying to the cough and the times within 3min after the cough is started are recorded, and T test is carried out on the result.

The treatment group adopts fructus terminaliae terminalia granules prepared in example 1 to carry out intragastric administration;

the negative control group adopts normal saline for gastric perfusion administration;

the positive control group adopts the Kebiqing and the intragastric administration, and the dosage is as follows: 500mg/100 g.

The results are shown in the following table:

comparison of latency and cough frequency in rats of each group

The results confirmed that: the treatment group can obviously prolong the cough latency period and reduce the cough frequency, has significant difference (P <0.05) compared with a negative control group, and has no significant difference compared with the effect of a positive control group.

Example 7 exemplary diseases

The first medical record is:

wangzhi, female, 6 years old, 2016, 7 months and 12 days for diagnosis.

Cough is more than half a year, especially at night, with difficulty in expectoration, nasal obstruction, thick nasal discharge, profuse sweating, pale red tongue with white greasy coating, poor appetite, dry stool.

Allergy to milk and egg.

Checking: pharynx red (+), bilateral tonsil swelling at I degree, heart and lung (-)

Preparing a formula: bai He Qing jin Jie (Bai He Qing jin granule).

Decoct them with boiling water for 6 doses.

The second medical record:

cao Zhi, woman, 4 years old. The physician needs to see the disease 3, 2 days in 2015.

Cough for 2 weeks, occasional cough, no nasal obstruction, sweating, defecation for 2-3 times/day, thin nature, clear urine, red tongue with yellow and greasy coating.

Checking: pharynx red (+), heart and lung (-).

Preparing a formula: bai He Qing jin Jie (Bai He Qing jin granule).

Decocted in cold water for 6 doses to heal.

The third medical record:

zhu Ching, male, 3 years old. The doctor is treated 5 months and 3 days in 2014.

Cough for more than 1 month, especially at night, difficult expectoration with phlegm, sneezing, no nasal discharge, nasal obstruction, poor sleep, large and clear tongue with red tongue and yellow and greasy coating.

Checking: pharynx red (++), bilateral tonsil II degree enlargement, cardiopulmonary (-)

Preparing a formula: bai He Qing jin Jie (Bai He Qing jin granule).

Decocted in cold water for 6 doses to heal.

The fourth medical record:

zhao, a man, 15 years old. The doctor visits 10 months and 20 days in 2013.

Cough is more than 1 month, especially at night. There are symptoms of difficult expectoration of phlegm, pharyngalgia, pharynx itch, thick nasal discharge, nasal obstruction, pain in the occiput, low fever, profuse sweating, constipation, poor sleep, red tongue with thick and greasy coating.

Checking: pharynx red (+), heart and lung (-).

Preparing a formula: bai He Qing jin Jie (Bai He Qing jin granule).

Decoct them with boiling water for 6 doses.

The fifth medical record is:

jiang some, women, 4 years old. Visit 3/16/2012.

Cough for more than 4 days, especially in the morning, with difficult expectoration, thick nasal discharge, no nasal obstruction, constipation, dry stool followed by thin stool, poor sleep, profuse sweating, red tongue with white greasy coating.

Preparing a formula: bai He Qing jin Jie (Bai He Qing jin granule).

Decoct them with boiling water for 6 doses.

Claims

1. A fructus terminaliae billericae Qingjin particle for treating cough after children infection is characterized by comprising the following raw material medicines: 4-30g of radix stemonae, 4-30g of myrobalan, 4-30g of fried scutellaria baicalensis, 4-30g of indigo naturalis, 4-30g of sea clam meal, 4-30g of honey-fried edestan, 4-30g of fried white mulberry root-bark, 4-30g of fried aster, 1-30g of oroxylum indicum, 4-30g of hairyvein agrimonia herb and bud, 4-30g of fried loquat leaf, 4-30g of dittany bark, 2-30g of cicada slough, 4-30g of cortex lycii radicis and 4-30g of almond; the radix Stemonae is radix Stemonae or radix Stemonae processed with Mel.

2. The myrobalan Qingjin particle of claim 1, which comprises the following components in parts by weight: 20-30g of radix stemonae, 20-30g of myrobalan, 15-25g of fried scutellaria baicalensis, 8-18g of indigo naturalis, 8-18g of sea clam meal, 15-25g of honey-fried edestan, 15-25g of fried white mulberry root-bark, 15-25g of fried aster, 1-10g of oroxylum indicum, 15-25g of hairyvein agrimonia herb and bud, 8-18g of fried loquat leaf, 8-18g of dittany bark, 2-18g of cicada slough, 5-15g of cortex lycii radicis and 5-15g of almond.

3. The myrobalan Qingjin particle of claim 2, which comprises the following components in parts by weight: 25g of radix stemonae, 25g of myrobalan, 20g of fried scutellaria baicalensis, 10g of indigo naturalis, 10g of sea clam powder, 20g of honey-fried edestan, 20g of fried white mulberry root-bark, 20g of fried aster, 5g of oroxylum indicum, 20g of hairyvein agrimonia herb, 15g of fried loquat leaf, 10g of dittany bark, 10g of cicada slough, 10g of cortex lycii radicis and 10g of almond.

4. A method for preparing fructus Chebulae Qingjin granules of claim 1, which comprises decocting the above herbs in water twice, the first time adding 4-10 times of water, the second time adding 4-10 times of water, each time decocting for 1-4 hr, filtering, collecting filtrate, concentrating, drying, adding appropriate amount of dextrin and sucrose, and granulating.

5. A method for preparing fructus Chebulae Qingjin granules as claimed in any one of claims 1-3, which comprises refluxing the above herbs with 95% ethanol twice, 4-10 times of ethanol for the first time and 4-10 times of ethanol for the second time, each refluxing time being 0.5-2 hr, filtering, collecting filtrate, concentrating, drying, adding appropriate amount of dextrin and sucrose, and granulating.

6. A fructus terminaliae bellericae and Qingjin traditional Chinese medicine composition for treating cough after children are infected is characterized by comprising the following raw material medicines: 4-30g of radix stemonae, 4-30g of myrobalan, 4-30g of fried scutellaria baicalensis, 4-30g of indigo naturalis, 4-30g of sea clam meal, 4-30g of honey-fried edestan, 4-30g of fried white mulberry root-bark, 4-30g of fried aster, 1-30g of oroxylum indicum, 4-30g of hairyvein agrimonia herb and bud, 4-30g of fried loquat leaf, 4-30g of dittany bark, 2-30g of cicada slough, 4-30g of cortex lycii radicis and 4-30g of almond; the radix Stemonae is radix Stemonae or radix Stemonae processed with Mel.

7. The fructus terminaliae bellericae heat-clearing traditional Chinese medicine composition according to claim 6, wherein the weight ratio of each component is as follows: 20-30g of radix stemonae, 20-30g of myrobalan, 15-25g of fried scutellaria baicalensis, 8-18g of indigo naturalis, 8-18g of sea clam meal, 15-25g of honey-fried edestan, 15-25g of fried white mulberry root-bark, 15-25g of fried aster, 3-25g of oroxylum indicum, 15-25g of hairyvein agrimonia herb and bud, 8-18g of fried loquat leaf, 8-18g of dittany bark, 5-18g of cicada slough, 5-15g of cortex lycii radicis and 5-15g of almond.

8. The fructus terminaliae bellericae heat-clearing traditional Chinese medicine composition according to claim 7, wherein the weight ratio of each component is as follows: 25g of radix stemonae, 25g of myrobalan, 20g of fried scutellaria baicalensis, 10g of indigo naturalis, 10g of sea clam powder, 20g of honey-fried edestan, 20g of fried white mulberry root-bark, 20g of fried aster, 5g of oroxylum indicum, 20g of hairyvein agrimonia herb, 15g of fried loquat leaf, 10g of dittany bark, 10g of cicada slough, 10g of cortex lycii radicis and 10g of almond.

9. The fructus terminaliae bellericae qingjin traditional Chinese medicine composition according to any one of claims 6 to 8, wherein the dosage form of the fructus terminaliae bellericae qingjin traditional Chinese medicine composition is as follows: granule, unguent, pill, oral liquid, pill, powder, or capsule.

10. A preparation method of the fructus terminaliae Billericae Qingjin traditional Chinese medicine composition according to any one of claims 6 to 8, adding 95% ethanol into the above medicinal materials for refluxing twice, wherein 4 to 10 times of ethanol is added for the first time, and 4 to 10 times of ethanol is added for the second time, the refluxing time is 0.5 to 2 hours each time, filtering, collecting filtrate, concentrating, drying to obtain extract, and preparing a pharmaceutically acceptable preparation.