CN107582939B - A Chinese medicinal composition for treating chronic bronchitis, and its preparation method - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic bronchitis, which is prepared from the following raw material medicines in parts by weight: 220-230 parts of changium smyrnioides, 220-230 parts of radix scrophulariae, 220-230 parts of rhizoma polygonati, 85-95 parts of adenophora tetraphylla, 85-95 parts of radix glehniae, 130-140 parts of radix pseudostellariae, 130-140 parts of acanthopanax senticosus, 85-95 parts of glossy privet fruit, 85-95 parts of radix polygonati officinalis, 85-95 parts of radix paeoniae alba, 40-50 parts of cacumen biotae, 40-50 parts of pyrrosia lingua, 40-50 parts of radix semiaquilegiae, 40-50 parts of polygala tenuifolia, 40-50 parts of dark plum and 40. The invention has definite curative effect, can effectively relieve clinical symptoms and shorten the treatment time, is economic and cheap, is easy to be received by patients, is convenient for clinical popularization, forms scale effect and generates good economic benefit.

Description

A Chinese medicinal composition for treating chronic bronchitis, and its preparation method

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating chronic bronchitis and a preparation method thereof.

Background

Chronic bronchitis is a chronic nonspecific inflammation of the trachea, bronchial mucosa and surrounding tissues. Clinically, cough and expectoration are the main symptoms, and the disease lasts for 3 months every year, and is continued for 2 years or more than 2 years. Eliminating other diseases with cough, expectoration, and asthma symptoms (such as pulmonary tuberculosis, pneumoconiosis, lung abscess, heart disease, cardiac insufficiency, bronchiectasis, bronchial asthma, chronic nasopharyngitis, and esophageal reflux syndrome).

The etiology of this disease is unclear and may be related to the following factors: (1) cigarettes, smoke, dust, irritating gases (sulphur dioxide, nitrogen dioxide, chlorine, ozone, etc.), harmful gases and harmful particles. (2) Viral, mycoplasma, bacterial, etc. (3) Immunity, age, and climate.

The disease has slow onset and long course of disease, and can be aggravated by repeated acute attacks. The main symptoms are cough, expectoration, or with wheezing. The acute exacerbation refers to sudden exacerbation of symptoms such as cough, expectoration, wheeze and the like.

Modern medicine adopts anti-infection, cough relieving, phlegm eliminating and asthma relieving treatments in acute exacerbation period, and common medicines comprise quinolones, macrocyclic esters, beta-lactams or sulfonamides, compound chloridizing agent, bromhexine, ambroxol hydrochloride, dextromethorphan, narcotine, aminophylline and the like. In the remission stage, smoking cessation, physique enhancement, cold prevention, immunomodulator and other treatment methods are adopted.

Modern medicine can well control the acute attack of the disease, but has defects in the treatment of remission stage, the control of symptoms and the treatment effect of treatment methods and treatment medicines on the disease are not ideal, the disease is easy to relapse, and in addition, part of medicines have certain side effects. Therefore, there is an urgent need to develop a drug with good therapeutic effect and no toxic and side effects.

The traditional Chinese medicine has unique advantages for treating chronic bronchitis. The traditional Chinese medicine does not have the name of chronic bronchitis, but mainly belongs to the category of cough in the traditional Chinese medicine according to symptoms and clinical manifestations of the chronic bronchitis. The traditional Chinese medicine considers that the attack of the cough has two types of exogenous pathogenic factors and internal injury, the exogenous pathogenic factors are six exogenous pathogenic factors attacking the lung, the internal injury is dysfunction of internal organs, the internal pathogenic factors dry the lung, and the lung fails to disperse and descend to cause cough. The diseased part is mainly in the lung, related to the liver and spleen, and often in the kidney. Chronic bronchitis caused by lung-kidney yin deficiency syndrome, failure of lung to control qi, failure of kidney deficiency to receive qi and cough. Yin deficiency of the lung and kidney failing to generate the same fluid, fire inflammation due to yin deficiency and fluid burning may lead to phlegm, qi deficiency of the lung and kidney failing to transform the fluid, and fluid accumulation leading to phlegm.

The traditional Chinese medicine theory considers that the treatment method of nourishing lung and kidney, resolving phlegm and relieving cough is adopted for the lung-kidney yin deficiency syndrome of chronic bronchitis.

Disclosure of Invention

The present invention aims at providing the traditional Chinese medicine composition for treating chronic bronchitis and the preparation method thereof, aiming at the defects of the prior art. The invention has the functions of nourishing lung and kidney, reducing phlegm and relieving cough, and has good curative effect and no side effect.

The object of the invention is achieved in the following way:

a traditional Chinese medicine composition for treating chronic bronchitis is prepared from the following raw material medicines in parts by weight: 220-230 parts of changium smyrnioides, 220-230 parts of radix scrophulariae, 220-230 parts of rhizoma polygonati, 85-95 parts of adenophora tetraphylla, 85-95 parts of radix glehniae, 130-140 parts of radix pseudostellariae, 130-140 parts of acanthopanax senticosus, 85-95 parts of glossy privet fruit, 85-95 parts of radix polygonati officinalis, 85-95 parts of radix paeoniae alba, 40-50 parts of cacumen biotae, 40-50 parts of pyrrosia lingua, 40-50 parts of radix semiaquilegiae, 40-50 parts of polygala tenuifolia, 40-50 parts of dark plum and 40.

The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 222-228 parts of changium smyrnioides, 222-228 parts of radix scrophulariae, 222-228 parts of rhizoma polygonati, 87-93 parts of adenophora tetraphylla, 87-93 parts of radix glehniae, 132-138 parts of radix pseudostellariae, 132-138 parts of acanthopanax senticosus, 87-93 parts of glossy privet fruit, 87-93 parts of radix polygonati officinalis, 87-93 parts of radix paeoniae alba, 42-48 parts of cacumen biotae, 42-48 parts of pyrrosia lingua, 42-48 parts of radix semiaquilegiae, 42-48 parts of polygala tenuifolia, 42-48 parts of dark plum and 42.

The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 225 parts of changium smyrnioides, 225 parts of radix scrophulariae, 225 parts of rhizoma polygonati, 90 parts of radix adenophorae, 90 parts of radix glehniae, 135 parts of radix pseudostellariae, 135 parts of acanthopanax, 90 parts of glossy privet fruit, 90 parts of radix polygonati officinalis, 90 parts of radix paeoniae alba, 45 parts of cacumen biotae, 45 parts of pyrrosia lingua, 45 parts of radix semiaquilegiae, 45 parts of polygala tenuifolia, 45 parts of dark plum fruit and 45 parts of.

The rhizoma Polygonati is steamed rhizoma Polygonati, and radix Stemonae is honey radix Stemonae.

The Chinese medicinal composition is an oral Chinese medicinal pill.

The traditional Chinese medicine pill is water pill, honeyed pill, water honeyed pill or concentrated pill.

The traditional Chinese medicine pill is a concentrated pill.

The preparation method of the traditional Chinese medicine composition concentrated pill for treating chronic bronchitis comprises the following specific steps:

(a) pulverizing radix Changii, fructus Ligustri Lucidi, radix Paeoniae alba, and cortex et radix Polygalae into fine powder, sieving, and mixing; sieving to obtain coarse powder;

(b) mixing radix scrophulariae, rhizoma Polygonati, radix Adenophorae, radix Glehniae, radix Pseudostellariae, radix Acanthopanacis Senticosi, rhizoma Polygonati Odorati, cacumen Platycladi, folium Pyrrosiae, radix Semiaquilegiae, mume fructus, and radix Stemonae with the coarse powder obtained in step (a), decocting with 8-10 times of water for 2 times, 2.5 hr for the first time and 2 hr for the second time, and mixing decoctions;

(c) filtering the decoction obtained in step (b), and concentrating the filtrate to obtain soft extract with relative density of 1.30-1.40 at 60 deg.C;

(d) and (c) uniformly mixing the uniformly mixed medicine fine powder obtained in the step (a) and the thick paste obtained in the step (c), making pills, drying and polishing to obtain the traditional Chinese medicine composition concentrated pills.

The effects and pharmacological actions of the raw material medicaments in the invention are as follows:

chang Dang Shen is sweet, slightly bitter and slightly cold. It enters lung, spleen and liver meridians. Moisten lung and resolve phlegm, nourish yin and harmonize stomach, calm liver and remove toxicity. Can be used for treating cough due to lung heat, emesis, regurgitation, anorexia, xerostomia, conjunctival congestion, vertigo, furuncle, and pyocutaneous disease. Pharmacological research proves that the changium smyrnioides has the effects of eliminating phlegm, relieving cough, relieving asthma, regulating immunity, resisting coagulation and improving circulation.

Xuan Shen is sweet, bitter, salty and slightly cold. It enters lung, stomach and kidney meridians. Clear heat and cool blood, nourish yin to reduce fire, remove toxicity and dissipate nodulation. Can be used for treating heat entering nutrient-blood, toxic heat and macula, yin impairment due to fever, crimson tongue with dipsosis, constipation due to body fluid consumption, bone-steaming cough, conjunctival congestion, pharyngalgia, diphtheria, scrofula, carbuncle, and sore. Pharmacological research proves that the figwort has the functions of antipyresis, antibiosis, anti-inflammation and antioxidation. Article Hui Jing Yao (essence of article): to clear the swelling of throat and purge the fire without root. "Shanxi Chinese medicine Zhi (Shanxi Chinese medicine Zhi)": nourishing yin to reduce pathogenic fire, clearing heat and cooling blood, promoting the production of body fluid, and relieving sore throat. "(materia Medica): the bitter taste is bitter and sweet, bitter can clear fire, sweet can nourish yin, and sweet taste is sweet, so the descending nature is also slow. In Ben Cao, it enters kidney meridian and goes beyond lung, so it can clear root-free floating fire and disperse phlegm, accumulation of heat and abscess in whole body. "

Huang Jing is sweet and neutral. It enters spleen, lung and kidney meridians. Tonify qi and yin, invigorate spleen, moisten lung and tonify kidney. Can be used for treating deficiency of spleen-stomach qi, asthenia, stomach yin deficiency, xerostomia, cough with little appetite, lung deficiency, cough with excessive consumption, hemoptysis, essence and blood deficiency, soreness of waist and knees, premature gray hair, and internal heat with thirst quenching effect. Pharmacological research proves that the sealwort has the functions of resisting pathogenic microorganisms and regulating immunity. Compendium of materia Medica: to tonify deficiency, stop cold and heat, and fill essence and marrow. "

Nan Sha Shen is sweet and slightly cold. It enters lung and stomach meridians. To nourish yin and clear lung-heat, nourish stomach and promote fluid production, resolve phlegm and tonify qi. Can be used for treating lung heat dry cough, yin deficiency chronic cough, dry cough with sticky phlegm, stomach yin deficiency, anorexia, emesis, qi yin deficiency, dysphoria, and xerostomia. Pharmacological research proves that the adenophora tetraphylla can improve cellular immunity and non-specific immunity, inhibit humoral immunity, have the effect of regulating immune balance, and have the effects of eliminating phlegm and resisting fungi.

Bei Sha Shen is sweet, slightly bitter and slightly cold. It enters lung and stomach meridians. To nourish yin, clear lung-heat, nourish stomach and promote fluid production. Can be used for treating lung heat dry cough, overstrain cough with phlegm and blood, stomach yin deficiency, fever with body fluid deficiency, dry throat, and thirst. Pharmacological research proves that the radix glehniae has the effects of immunosuppression and antipyretic and analgesic effects. Des-join materia Medica: nourishing yin to control yang, clearing away heat and nourishing water, treating chronic cough and consumptive lung disease. "compilation of medicinal plants in northeast China: it is used to treat chronic bronchitis, pulmonary tuberculosis, pulmonary atelectasis, lung abscess, etc. "Xiaopin medicine cage" (products for medicine cage): for cough due to lung deficiency, it is usually combined with Dang Shen, Yuan Shen and Bei Shen, or with Jiang Qi-descending and phlegm-resolving herbs, named san Shen Yin, to treat cough due to lung deficiency. "

Taizi Shen is sweet, slightly bitter and neutral. It enters spleen and lung meridians. To replenish qi, invigorate the spleen, promote the production of body fluid and moisten the lung. Can be used for treating spleen deficiency, asthenia, deficiency of both qi and yin, spontaneous perspiration, thirst, and dry cough due to lung dryness. Pharmacological research proves that the radix pseudostellariae has the effects of regulating immunity, resisting fatigue and stress and enhancing hypoxia tolerance.

Acanthopanax senticosus, pungent and slightly bitter. It enters spleen, kidney and heart meridians. To replenish qi, invigorate the spleen, tonify the kidney and induce tranquilization. Can be used for treating deficiency of spleen-lung qi, asthenia, anorexia, deficiency of both lung and kidney, cough, asthma, soreness of waist and knees, deficiency of heart and spleen, insomnia, and dreaminess. Pharmacological research proves that acanthopanax has the functions of enhancing immunity, resisting inflammation, relieving cough and eliminating phlegm. Changbai mountain plant medicine records: qi invigorating and essence replenishing are indicated for qi deficiency and hypodynamia, chronic bronchitis. "

Glossy privet fruit, sweet, bitter and cool. It enters liver and kidney meridians. Nourishing liver and kidney, improving eyesight and blackening hair. Can be used for treating liver and kidney yin deficiency, giddiness, tinnitus, soreness of waist and knees, premature gray hair, dim eyesight, internal heat, diabetes, and hectic fever. Pharmacological research proves that the glossy privet fruit has the effects of resisting inflammation, promoting immunologic function, inhibiting allergic reaction and the like. Shen nong Ben Cao Jing: to strengthen the middle energizer, calm the five internal organs, nourish the spirit and cure various diseases. "(renewal of materia Medica): nourishing yin, tonifying kidney, invigorating qi and soothing liver. "(Ben Cao Jing Shu): for the deficiency of essence, the essence is supplemented with the flavor, the kidney is covered with the cold, the kidney is soft due to deficiency heat, the medicine has all yin smell, enters the essential product of the kidney for removing heat and replenishing essence, and the kidney is supplemented, so that the five internal organs are self-calmed, the spirit is self-sufficient, the body is fattened and healthy is got after all diseases are treated. "

Yu Zhu is sweet and slightly cold. It enters lung and stomach meridians. To nourish yin, moisten dryness, promote the production of body fluid and quench thirst. Can be used for treating yin injury of lung and stomach, cough due to dryness-heat, dry throat, thirst, and diabetes due to internal heat. Pharmacological research proves that the polygonatum odoratum has the function of regulating the immunity. Guangxi Zhi TCM (TCM treatise on Guangxi): it is indicated for yin deficiency, hyperhidrosis, dry cough and lung atrophy. "(this herbal is easy to read): herbs with moistening property, it is the best herb for nourishing yin for its excellence of … …, for instance, it is the deficiency due to warm wind and hot wind, and … … herbs with warm wind and hot wind are most apt to damage yin, while yin-nourishing herbs are also apt to obstruct pathogens, Yu Zhu is sweet and mild in nature and moisten, but tonify without obstructing pathogens. "

White peony root, radix Paeoniae alba, bitter and sour, and slightly cold. It enters liver and spleen meridians. Nourish blood and regulate menstruation, astringe yin and check sweating, soften liver and relieve pain, and calm liver yang. Can be used for treating blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm and pain, headache, and vertigo. Pharmacological research proves that the white peony root has the effects of resisting inflammation, easing pain, resisting bacteria and microorganisms and regulating immunity. The book materia Medica is as follows: white herbs are sweet in flavor and rich in tonics, so they enter blood system to tonify deficiency of blood heat, purge excess of liver fire, clear deficiency heat and relieve the three syndromes due to heat. "meaning of pharmacy": the property of white peony root is slightly bitter and can tonify yin, and slightly sour can astringe. Liver regeneration is caused by liver-qi stagnation due to acid. Liver desire to disperse and astringe, and take acid to suppress liver. "

Ce Bai Ye, bitter, astringent and cold. It enters lung, liver and spleen meridians. Cool blood to stop bleeding, resolve phlegm to stop cough, promote hair growth and blacken hair. Can be used for treating hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, metrostaxis, cough due to lung heat, alopecia due to blood heat, and premature gray hair. Pharmacological research proves that the cacumen biotae has the effects of relieving cough, eliminating phlegm, relieving asthma and stopping bleeding, has the effects of resisting staphylococcus aureus, catacoccus, dysentery bacillus, typhoid bacillus, diphtheria bacillus, streptococcus B, bacillus anthracis and the like, and has the effects of inhibiting influenza viruses and herpes viruses. Treatise on medilin: to purge the adverse flow of lung qi and clear heat in blood system. "

Shi Wei is sweet, bitter and slightly cold. It enters lung and bladder meridians. Induce diuresis to treat stranguria, clear lung to relieve cough, cool blood to stop bleeding. Can be used for treating heat stranguria, bloody stranguria, stranguria with stone, urinary obstruction, stranguria with pain, lung heat cough and asthma, hematemesis, epistaxis, hematuria, and metrorrhagia. Pharmacological research proves that the pyrrosia lingua has the effects of relieving cough and eliminating phlegm, and has the effects of resisting bacteria and viruses. Compendium of materia Medica: to clear lung qi. "(the materia Medica is New): the lung-heat clearing herbs are used as resources to promote diuresis by dredging the bladder. The essential essentials of medilin codification states that clearing lung-heat and lowering qi can produce kidney water, strengthen kidney, soothe liver and promote diuresis. "materia Medica Chong Source: shiwei helps the essence qi of lung and kidney to pass through the upper and lower parts, and water and fluid are moistening upward to open the upper orifice and the outer orifice, while lung qi is transforming downward to promote the flow of water to promote urination . "

Tian Ma Zi is sweet, bitter and cold. It enters liver and stomach meridians. Clear heat and remove toxicity, resolve swelling and dissipate nodulation. Can be used for treating carbuncle, furuncle, pharyngalgia, mammary abscess, scrofula, and snake and insect bite. Treatise on medilin: to purge pathogenic fire related to liver, gallbladder and kidney, and to remove all heat-toxicity. "the materia Medica is required: mainly injure phlegm fire internally. "Guizhou folk prescription drug Collection: clearing away heat and toxic material, relieving asthma. "

Yuan Zhi is bitter, pungent and warm. It enters heart, kidney and lung meridians. Tranquilization and intelligence development, heart and kidney communication, phlegm elimination and swelling reduction. Can be used for treating insomnia, dreaminess, amnesia, pavor, absentmindedness, expectoration, skin and external diseases, swelling and pain of breast caused by imbalance between heart-yang and kidney-yin. Pharmacological research proves that polygala has the effect of eliminating phlegm, can reflexively increase the secretion of bronchus to effectively eliminate phlegm, and also has the obvious effect of relieving cough. Shen nong Ben Cao Jing: "mainly cough and dyspnea impairment, tonify deficiency. "(renewal of materia Medica): "moving qi and dispersing qi stagnation" and excelling in eliminating phlegm. (for acute paralysis of the throat and night sweat due to yin deficiency) is described in the materia Medica of materia Medica. "(the summary of the present materia Medica): polygala tenuifolia, radix Ginseng, SHASHEN, and Ophiopogon japonicus can tonify lung, and rehmanniae radix, fructus Lycii, and rhizoma Dioscoreae can tonify kidney. "the West records of medical professions: its property is good at regulating lung, making the lung xi Xin be pure and natural, while the lung breathes in the right direction and phlegm and saliva are dissolved, i.e. cough can be stopped , it is good as the essential drug for nourishing lung. "

Dark plum, sour, astringent and flat. It enters liver, spleen, lung and large intestine meridians. Astringe lung, astringe intestine, promote fluid production and relieve ascaris. Can be used for treating lung deficiency, chronic cough, chronic diarrhea, dysentery, asthenia heat, diabetes, ascariasis, emesis, and abdominal pain. Pharmacological research proves that the dark plum has an antimicrobial effect, and dark plum water decoction has an inhibiting and killing effect on bacillus foeniculi, shigella, salmonella, escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, meningococcus, various clinically-separated enterococcus and the like. Compendium of materia Medica: astringe lung and astringe intestine, it is indicated for chronic cough. "

Stemona root, radix Stemonae, sweet and bitter, slightly warm. It enters lung meridian. Moistening lung, descending qi to relieve cough, killing parasite and killing louse. Can be used for treating chronic cough, pulmonary tuberculosis cough, and cough; it is used for treating head louse, body louse, enterobiasis, and pudendal pruritus. Honey radix Stemonae has effects of moistening lung and relieving cough, and can be used for treating deficiency-type cough. Pharmacological research proves that radix stemonae has the effects of resisting pathogenic microorganisms, relieving cough, eliminating phlegm and relieving asthma.

The prescription structure and the compatibility mechanism of the traditional Chinese medicine composition are as follows:

the common chronic bronchitis syndrome is lung-kidney yin deficiency syndrome, which is caused by lung-kidney yin deficiency, wherein the lung is the mother of the kidney, and cough and asthma are caused by lung-kidney yin deficiency, yin deficiency generating internal heat, deficient fire flaming up and lung failing to descend for a long time; when the deficient fire burns body fluids, it can cause dry and sore throat, tidal fever in the afternoon, and even burn lung collaterals, resulting in blood in the phlegm; fire due to yin deficiency can burn fluid into phlegm, and qi of lung and kidney can not transform fluid into phlegm. It is indicated for both yin and blood of lung and kidney, and also for resolving phlegm and stopping cough.

The prescription is prepared by improving the prescription ' Sanshen drink ' in the Qing Dynasty ' from the Xiao Pin of the drug cage, and the original text records that: for cough due to lung deficiency, it is usually combined with Dang Shen, Yuan Shen (scrophularia root), Bei Sha Shen or with Jiang Qi-descending and phlegm-resolving herbs, named san Shen Yin, to treat cough due to lung deficiency. The theory that cough is treated by the traditional Chinese medicine "treating the cough in the upper part, treating the cough in the middle part and treating the cough in the lower part" means treating the cough from the lung, "treating the cough in the middle part" means treating the cough from the spleen, "treating the cough in the lower part" means treating the cough from the kidney. The sanshen yin is indicated for lung with Bei Sha Shen, spleen with Dang Shen and kidney with Xuan Shen. The invention is based on the three-ginseng drink, and changium smyrnioides is used for replacing codonopsis pilosula. Radix Codonopsis is neutral in nature, and radix Changii is slightly cold in nature, has effects of invigorating spleen, benefiting lung, nourishing blood, and promoting fluid production, and can be used for treating cough and asthma due to lung-spleen qi deficiency; the changium smyrnioides has the effects of moistening lung, reducing phlegm, nourishing yin and harmonizing stomach, is used for treating cough with lung heat, and can clear heat, moisten lung, reduce phlegm and relieve cough besides supplementing qi and nourishing yin. Therefore, the change of the codonopsis pilosula into the changium smyrnioides is beneficial to clearing heat, moistening lung, reducing phlegm and relieving cough, and is more in line with the characteristics of lung-kidney yin deficiency syndrome of chronic bronchitis. The invention adds a plurality of qi-tonifying and yin-nourishing products for nourishing lung and kidney, adds products for astringing lung, eliminating phlegm, relieving cough, nourishing blood, cooling blood, clearing heat and relieving sore throat, enhances the curative effect of the ancient formula and can effectively treat the accompanying symptoms of chronic bronchitis.

The prescription takes changium smyrnioides, figwort and sealwort as monarch drugs. Changium smyrnioides moistens lung to reduce phlegm, and nourishes yin and harmonizes stomach; radix scrophulariae enters lung, stomach and kidney channels, has effects of clearing heat and cooling blood, nourishing yin and lowering fire, promoting fluid production and relieving sore throat, and purging floating fire without root; rhizoma Polygonati is sweet and neutral, and has effects of invigorating qi, nourishing yin, invigorating spleen, moistening lung, invigorating kidney, and tonifying deficiency and marrow. The three medicines are combined to supplement qi and nourish yin, reduce phlegm and clear heat, lower fire and relieve sore throat, clear and nourish qi yin of lung, spleen and kidney and especially nourish lung and kidney, enable metal water to grow mutually, nourish yin and strengthen water and clear floating fire of yin deficiency, and are monarch medicines together.

Radix adenophorae, radix glehniae, radix pseudostellariae, acanthopanax, glossy privet fruit, radix polygonati officinalis and radix paeoniae alba are used as ministerial medicines, and the radix adenophorae has the effects of nourishing yin, clearing away the lung-heat, tonifying stomach, promoting the secretion of saliva, reducing phlegm and tonifying qi; bei Sha Shen can nourish yin and clear lung-heat, tonify stomach and promote fluid production. The two herbs are commonly used in the same pair, and are often combined in mutual reinforcement for tonifying qi and yin, clearing lung-heat and resolving phlegm, especially good at treating dry cough due to yin deficiency of lung and kidney. Radix pseudostellariae has the effects of tonifying qi and spleen, promoting the production of body fluid and moistening lung; acanthopanax senticosus has the functions of tonifying qi and spleen, tonifying kidney and soothing nerves, and is combined with radix adenophorae and radix glehniae to strengthen the functions of tonifying qi and nourishing yin. Fructus Ligustri Lucidi has effects in nourishing essence and blood of liver and kidney; yuzhu has effects of nourishing yin, moistening dryness, promoting fluid production, quenching thirst, clearing and nourishing yin injury of lung and stomach, and can eliminate dryness-heat cough, dry throat and thirst; the white peony root has the functions of nourishing blood, astringing yin and reducing deficiency heat, and the three medicines are used together to nourish yin blood of lung and kidney. The medicines are used as ministerial medicines together, and the effects of supplementing qi, nourishing yin and clearing heat of monarch medicines are assisted.

The Chinese arborvitae twig, the pyrrosia lingua, the semiaquilegia root, the polygala tenuifolia and the dark plum are taken as adjuvant drugs, and the Chinese arborvitae twig can eliminate phlegm and relieve cough, cool blood and stop bleeding and clear heat in the lung channel and blood system; shiwei clears lung to relieve cough, cools blood to stop bleeding, clears lung to reduce qi, can generate kidney water, leads the upper part and the lower part to be communicated, generates mutually golden water, combines the two medicines, can clear lung to eliminate phlegm to relieve cough, can cool blood to nourish blood, and clear heat of lung meridian and blood. Tian Ma Zi can clear heat and remove toxicity, relieve swelling and dissipate stagnation, and improve pharyngalgia due to yin deficiency and fire heat. Polygala root, radix polygalae, radix adenophorae, radix scrophulariae, radix polygalae, radix adenophorae and radix polygalae, and can eliminate phlegm and relieve cough, regulate lung qi, serve as an essential drug for nourishing lung and tonify kidney; wu Mei astringes lung, so it is suitable for chronic cough due to lung deficiency, and both herbs are used together to dispel phlegm, tonify kidney, astringe lung and relieve cough. The above drugs are used as adjuvant drugs.

Radix Stemonae is used as a guiding drug. Radix Stemonae is sweet, bitter and slightly warm, and enters lung meridian. Moisten lung and descend qi to stop cough, and is used for treating chronic cough.

The compatibility of the whole formula is characterized in that: nourish kidney and protect lung, generate golden water phase, remove floating fire due to yin deficiency, and treat both principal and secondary aspect of disease. Replenishing qi and nourishing yin, mainly clearing and nourishing, preventing warm heat from damaging yin, and replenishing qi without using the sweet and warm ginseng and astragalus root, but instead of the sweet and flat, sweet and cool and slightly cold radix adenophorae, radix glehniae, radix pseudostellariae and changium smyrnioides; nourishing, cooling blood and stopping bleeding, clearing heat from lung meridian and blood system, and preventing yin deficiency and fire heat from damaging blood and consuming blood; moisten lung and resolve phlegm, astringe lung and stop cough, lower fire and relieve sore throat, treat both manifestation and root cause of disease. The formula is mainly used for nourishing lung and kidney, can tonify qi and nourish yin, benefit yin and blood, clear deficiency fire, reduce phlegm and astringe lung to relieve cough after being taken, has reasonable formula and hits the pathogenesis.

In addition, the medicaments with the phlegm reducing effect, such as changium smyrnioides, adenophora tetraphylla, acanthopanax, polygala tenuifolia, and the like, are compatible with the medicaments for nourishing kidney yin, such as figwort, rhizoma polygonati, glossy privet fruit, polygonatum, radix paeoniae alba, and the like, so that the defect that the yin nourishing medicaments are greasy and generate phlegm can be avoided. The combination of figwort and radix semiaquilegiae is helpful for improving pharyngalgia symptoms frequently appearing in chronic bronchitis.

The traditional Chinese medicine composition provided by the invention has the functions of nourishing lung and kidney, eliminating phlegm and relieving cough, is mainly used for treating lung and kidney yin deficiency syndrome of chronic bronchitis, and has the clinical manifestations of no phlegm or little white and sticky phlegm, difficult cough, blood in phlegm, dry mouth and throat. Dysphoria with feverish sensation in the chest, palms and soles, tidal fever, night sweat, shortness of breath, mental fatigue, headache, vertigo, soreness of the waist and limbs, red tongue with little coating or smooth coating, thready and rapid pulse.

Compared with the prior art, the invention has the beneficial effects that:

1. the traditional Chinese medicine compound preparation has the functions of nourishing lung and kidney, eliminating phlegm and relieving cough, treats both principal and secondary aspects of diseases, and has no phlegm or little white and sticky phlegm, difficult coughing-out, blood in phlegm, dry mouth and dry throat in chronic bronchitis. Dysphoria with feverish sensation in the chest, palms and soles, tidal fever, night sweat, shortness of breath, mental fatigue, headache, vertigo, soreness of the waist and limbs, red tongue with little coating or smooth coating, thready and rapid pulse, etc.

2. The invention has less medicinal ingredients and simple preparation process, can be prepared into water-paste pills, honeyed pills, water-paste honeyed pills or concentrated pills and other dosage forms according to requirements, and is convenient to take.

3. The preparation method of the concentrated pill of the invention takes part of the medicinal powder and part of the medicinal materials to extract into paste to be used as adhesive for preparing the pill, thereby reducing the dosage and improving the compliance of the taking medicine.

4. Clinical application shows that the traditional Chinese medicine composition has definite curative effect, can effectively relieve clinical symptoms and shorten treatment time, is economic and cheap, is easy to be received by patients, is convenient for clinical popularization, forms scale effect and generates good economic benefit.

Detailed Description

The water-honeyed pill, the honeyed pill and the water-honeyed pill are prepared by the existing preparation method.

Example 1:

a traditional Chinese medicine composition for treating chronic bronchitis is prepared from the following raw material medicines in parts by weight: 220-230 parts of changium smyrnioides, 220-230 parts of radix scrophulariae, 220-230 parts of rhizoma polygonati, 85-95 parts of adenophora tetraphylla, 85-95 parts of radix glehniae, 130-140 parts of radix pseudostellariae, 130-140 parts of acanthopanax senticosus, 85-95 parts of glossy privet fruit, 85-95 parts of radix polygonati officinalis, 85-95 parts of radix paeoniae alba, 40-50 parts of cacumen biotae, 40-50 parts of pyrrosia lingua, 40-50 parts of radix semiaquilegiae, 40-50 parts of polygala tenuifolia, 40-50 parts of dark plum and 40.

The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 222-228 parts of changium smyrnioides, 222-228 parts of radix scrophulariae, 222-228 parts of rhizoma polygonati, 87-93 parts of adenophora tetraphylla, 87-93 parts of radix glehniae, 132-138 parts of radix pseudostellariae, 132-138 parts of acanthopanax senticosus, 87-93 parts of glossy privet fruit, 87-93 parts of radix polygonati officinalis, 87-93 parts of radix paeoniae alba, 42-48 parts of cacumen biotae, 42-48 parts of pyrrosia lingua, 42-48 parts of radix semiaquilegiae, 42-48 parts of polygala tenuifolia, 42-48 parts of dark plum and 42.

The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 225 parts of changium smyrnioides, 225 parts of radix scrophulariae, 225 parts of rhizoma polygonati, 90 parts of radix adenophorae, 90 parts of radix glehniae, 135 parts of radix pseudostellariae, 135 parts of acanthopanax, 90 parts of glossy privet fruit, 90 parts of radix polygonati officinalis, 90 parts of radix paeoniae alba, 45 parts of cacumen biotae, 45 parts of pyrrosia lingua, 45 parts of radix semiaquilegiae, 45 parts of polygala tenuifolia, 45 parts of dark plum fruit and 45 parts of.

The rhizoma Polygonati is steamed rhizoma Polygonati, and radix Stemonae is honey radix Stemonae.

The Chinese medicinal composition is an oral Chinese medicinal pill.

The traditional Chinese medicine pill is water pill, honeyed pill, water honeyed pill or concentrated pill.

The traditional Chinese medicine pill is a concentrated pill.

The preparation method of the traditional Chinese medicine composition concentrated pill for treating chronic bronchitis comprises the following specific steps:

(a) pulverizing radix Changii, fructus Ligustri Lucidi, radix Paeoniae alba, and cortex et radix Polygalae into fine powder, sieving, and mixing; sieving to obtain coarse powder;

(b) mixing radix scrophulariae, rhizoma Polygonati, radix Adenophorae, radix Glehniae, radix Pseudostellariae, radix Acanthopanacis Senticosi, rhizoma Polygonati Odorati, cacumen Platycladi, folium Pyrrosiae, radix Semiaquilegiae, mume fructus, and radix Stemonae with the coarse powder obtained in step (a), decocting with 8-10 times of water for 2 times, 2.5 hr for the first time and 2 hr for the second time, and mixing decoctions;

(c) filtering the decoction obtained in step (b), and concentrating the filtrate to obtain soft extract with relative density of 1.30-1.40 at 60 deg.C;

(d) and (c) uniformly mixing the uniformly mixed medicine fine powder obtained in the step (a) and the thick paste obtained in the step (c), making pills, drying and polishing to obtain the traditional Chinese medicine composition concentrated pills.

Example 2:

a traditional Chinese medicine composition for treating chronic bronchitis is prepared from the following raw material medicines in parts by weight: 220g of changium smyrnioides, 220g of figwort root, 220g of steamed sealwort, 85g of adenophora tetraphylla, 85g of radix glehniae, 130g of radix pseudostellariae, 130g of acanthopanax senticosus, 85g of glossy privet fruit, 85g of radix polygonati officinalis, 85g of radix paeoniae alba, 40g of cacumen biotae, 40g of pyrrosia lingua, 40g of muskmelon semiaquilegia, 40g of polygala tenuifolia, 40g of.

The Chinese medicinal composition is in the form of oral watered pill. The preparation method comprises the following steps: pulverizing the raw materials into fine powder, sieving, and mixing. Adding 2g of starch into every 100g of powder, and mixing uniformly. Adding appropriate amount of water, making into pill, drying, coating with carbon coat, and polishing to obtain watered pill.

Example 3:

a traditional Chinese medicine composition for treating chronic bronchitis is prepared from the following raw material medicines in parts by weight: 221g of changium smyrnioides, 221g of figwort root, 221g of steamed sealwort, 86g of adenophora tetraphylla, 86g of radix glehniae, 131g of radix pseudostellariae, 131g of acanthopanax senticosus, 86g of glossy privet fruit, 86g of radix polygonati officinalis, 86g of radix paeoniae alba, 41g of cacumen biotae, 41g of pyrrosia lingua, 41g of radix semiaquilegiae, 41g of polygala tenuifolia, 41g of dark plum fruit.

The Chinese medicinal composition is oral honeyed pill. The preparation method comprises the following steps: pulverizing the raw materials into fine powder, sieving, and mixing. Adding 40-60 g of refined honey into every 100g of powder, making pills, and drying to obtain honeyed pills.

Example 4:

a traditional Chinese medicine composition for treating chronic bronchitis is prepared from the following raw material medicines in parts by weight: 222g of changium smyrnioides, 222g of figwort root, 222g of steamed sealwort, 87g of adenophora tetraphylla, 87g of radix glehniae, 132g of radix pseudostellariae, 132g of acanthopanax senticosus, 87g of glossy privet fruit, 87g of radix polygonati officinalis, 87g of radix paeoniae alba, 42g of cacumen biotae, 42g of pyrrosia lingua, 42g of radix semiaquilegiae, 42g of polygala tenuifolia, 42g of dark plum fruit.

The Chinese medicinal composition is oral water-honeyed pill. The preparation method comprises the following steps: pulverizing the raw materials into fine powder, sieving, and mixing. Adding a proper amount of water into every 100g of the powder by using 20-30 g of refined honey, making pills, and drying to obtain the water-honeyed pills.

Example 5:

a traditional Chinese medicine composition for treating chronic bronchitis is prepared from the following raw material medicines in parts by weight: 223g of changium smyrnioides, 223g of radix scrophulariae, 223g of steamed rhizoma polygonati, 88g of radix adenophorae, 88g of radix glehniae, 133g of radix pseudostellariae, 133g of acanthopanax, 88g of glossy privet fruit, 88g of radix polygonati officinalis, 88g of radix paeoniae alba, 43g of cacumen biotae, 43g of pyrrosia lingua, 43g of radix semiaquilegiae, 43g of polygala tenuifolia, 43g of dark plum fruit and 43g of honey.

The Chinese medicinal composition is oral concentrated pill.

The preparation method of the traditional Chinese medicine composition concentrated pill for treating chronic bronchitis comprises the following specific steps:

(a) pulverizing radix Changii, fructus Ligustri Lucidi, radix Paeoniae alba, and cortex et radix Polygalae into fine powder, sieving, and mixing; sieving to obtain coarse powder;

(b) decocting radix scrophulariae, rhizoma Polygonati, radix Adenophorae, radix Glehniae, radix Pseudostellariae, radix Acanthopanacis Senticosi, rhizoma Polygonati Odorati, cacumen Platycladi, folium Pyrrosiae, radix Semiaquilegiae, mume fructus, and radix Stemonae with 8 times of water for 2 times, 2.5 hr for the first time and 2 hr for the second time, and mixing decoctions;

(c) filtering the decoction obtained in the step (b), and concentrating the filtrate into thick paste with the relative density of 1.30 at 60 ℃;

(d) and (c) uniformly mixing the uniformly mixed medicine fine powder obtained in the step (a) and the thick paste obtained in the step (c), making pills, drying and polishing to obtain the traditional Chinese medicine composition concentrated pills.

Example 6:

a traditional Chinese medicine composition for treating chronic bronchitis is prepared from the following raw material medicines in parts by weight: 224g of changium smyrnioides, 224g of figwort root, 224g of steamed sealwort, 89g of adenophora tetraphylla, 89g of radix glehniae, 134g of radix pseudostellariae, 134g of acanthopanax, 89g of glossy privet fruit, 89g of radix polygonati officinalis, 89g of white paeony root, 44g of cacumen biotae, 44g of pyrrosia lingua, 44g of muskroot-like semiaquilegia root, 44g of polygala tenuifolia, 44g of dark.

The Chinese medicinal composition is oral concentrated pill.

The preparation method of the traditional Chinese medicine composition concentrated pill for treating chronic bronchitis comprises the following specific steps:

(a) pulverizing radix Changii, fructus Ligustri Lucidi, radix Paeoniae alba, and cortex et radix Polygalae into fine powder, sieving, and mixing; sieving to obtain coarse powder;

(b) mixing radix scrophulariae, rhizoma Polygonati, radix Adenophorae, radix Glehniae, radix Pseudostellariae, radix Acanthopanacis Senticosi, rhizoma Polygonati Odorati, cacumen Platycladi, folium Pyrrosiae, radix Semiaquilegiae, mume fructus, and radix Stemonae with the coarse powder obtained in step (a), decocting with 9 times of water for 2 times, 2.5 hr for the first time and 2 hr for the second time, and mixing decoctions;

(c) filtering the decoction obtained in the step (b), and concentrating the filtrate into thick paste with the relative density of 1.32 at 60 ℃;

(d) and (c) uniformly mixing the uniformly mixed medicine fine powder obtained in the step (a) and the thick paste obtained in the step (c), making pills, drying and polishing to obtain the traditional Chinese medicine composition concentrated pills.

Example 7:

a traditional Chinese medicine composition for treating chronic bronchitis is prepared from the following raw material medicines in parts by weight: 225g of changium smyrnioides, 225g of figwort root, 225g of steamed sealwort, 90g of adenophora tetraphylla, 90g of radix glehniae, 135g of radix pseudostellariae, 135g of acanthopanax senticosus, 90g of glossy privet fruit, 90g of radix polygonati officinalis, 90g of radix paeoniae alba, 45g of cacumen biotae, 45g of pyrrosia lingua, 45g of radix semiaquilegiae, 45g of polygala tenuifolia, 45g of dark plum fruit.

The Chinese medicinal composition is oral concentrated pill.

The preparation method of the traditional Chinese medicine composition concentrated pill for treating chronic bronchitis comprises the following specific steps:

(a) pulverizing radix Changii, fructus Ligustri Lucidi, radix Paeoniae alba, and cortex et radix Polygalae into fine powder, sieving, and mixing; sieving to obtain coarse powder;

(b) taking radix scrophulariae, rhizoma polygonati, radix adenophorae, radix glehniae, radix pseudostellariae, acanthopanax, radix polygonati officinalis, cacumen biotae, pyrrosia lingua, radix semiaquilegiae, dark plum and radix stemonae, adding 10 times of water into the coarse powder obtained in the step (a), decocting for 2 times, 2.5 hours for the first time and 2 hours for the second time, and combining decoction;

(c) filtering the decoction obtained in the step (b), and concentrating the filtrate into thick paste with the relative density of 1.34 at 60 ℃;

(d) and (c) uniformly mixing the uniformly mixed medicine fine powder obtained in the step (a) and the thick paste obtained in the step (c), making pills, drying and polishing to obtain the traditional Chinese medicine composition concentrated pills.

Example 8:

a traditional Chinese medicine composition for treating chronic bronchitis is prepared from the following raw material medicines in parts by weight: 226g of changium smyrnioides, 226g of figwort root, 226g of steamed sealwort, 91g of adenophora tetraphylla, 91g of radix glehniae, 136g of radix pseudostellariae, 136g of acanthopanax, 91g of glossy privet fruit, 91g of radix polygonati officinalis, 91g of radix paeoniae alba, 46g of cacumen biotae, 46g of pyrrosia lingua, 46g of radix semiaquilegiae, 46g of polygala tenuifolia, 46g of dark plum fruit and 46 g.

The Chinese medicinal composition is oral concentrated pill.

The preparation method of the traditional Chinese medicine composition concentrated pill for treating chronic bronchitis comprises the following specific steps:

(a) pulverizing radix Changii, fructus Ligustri Lucidi, radix Paeoniae alba, and cortex et radix Polygalae into fine powder, sieving, and mixing; sieving to obtain coarse powder;

(b) decocting radix scrophulariae, rhizoma Polygonati, radix Adenophorae, radix Glehniae, radix Pseudostellariae, radix Acanthopanacis Senticosi, rhizoma Polygonati Odorati, cacumen Platycladi, folium Pyrrosiae, radix Semiaquilegiae, mume fructus, and radix Stemonae with 8 times of water for 2 times, 2.5 hr for the first time and 2 hr for the second time, and mixing decoctions;

(c) filtering the decoction obtained in the step (b), and concentrating the filtrate into thick paste with the relative density of 1.35 at 60 ℃;

(d) and (c) uniformly mixing the uniformly mixed medicine fine powder obtained in the step (a) and the thick paste obtained in the step (c), making pills, drying and polishing to obtain the traditional Chinese medicine composition concentrated pills.

Example 9:

a traditional Chinese medicine composition for treating chronic bronchitis is prepared from the following raw material medicines in parts by weight: 227g of changium smyrnioides, 227g of figwort root, 227g of steamed sealwort, 92g of adenophora tetraphylla, 92g of radix glehniae, 137g of radix pseudostellariae, 137g of acanthopanax, 92g of glossy privet fruit, 92g of radix polygonati officinalis, 92g of white paeony root, 47g of cacumen biotae, 47g of pyrrosia lingua, 47g of radix semiaquilegiae, 47g of polygala tenuifolia, 47g of dark plum fruit and 47 g.

The Chinese medicinal composition is oral concentrated pill.

The preparation method of the traditional Chinese medicine composition concentrated pill for treating chronic bronchitis comprises the following specific steps:

(a) pulverizing radix Changii, fructus Ligustri Lucidi, radix Paeoniae alba, and cortex et radix Polygalae into fine powder, sieving, and mixing; sieving to obtain coarse powder;

(b) mixing radix scrophulariae, rhizoma Polygonati, radix Adenophorae, radix Glehniae, radix Pseudostellariae, radix Acanthopanacis Senticosi, rhizoma Polygonati Odorati, cacumen Platycladi, folium Pyrrosiae, radix Semiaquilegiae, mume fructus, and radix Stemonae with the coarse powder obtained in step (a), decocting with 9 times of water for 2 times, 2.5 hr for the first time and 2 hr for the second time, and mixing decoctions;

(c) filtering the decoction obtained in the step (b), and concentrating the filtrate into thick paste with the relative density of 1.36 at 60 ℃;

(d) and (c) uniformly mixing the uniformly mixed medicine fine powder obtained in the step (a) and the thick paste obtained in the step (c), making pills, drying and polishing to obtain the traditional Chinese medicine composition concentrated pills.

Example 10:

a traditional Chinese medicine composition for treating chronic bronchitis is prepared from the following raw material medicines in parts by weight: 228g of changium smyrnioides, 228g of figwort root, 228g of steamed sealwort, 93g of adenophora tetraphylla, 93g of radix glehniae, 138g of radix pseudostellariae, 138g of acanthopanax senticosus, 93g of glossy privet fruit, 93g of radix polygonati officinalis, 93g of white paeony root, 48g of cacumen biotae, 48g of pyrrosia lingua, 48g of muskmelon semiaquilegia seed, 48g of polygala tenuifolia, 48 g.

The Chinese medicinal composition is oral concentrated pill.

The preparation method of the traditional Chinese medicine composition concentrated pill for treating chronic bronchitis comprises the following specific steps:

(a) pulverizing radix Changii, fructus Ligustri Lucidi, radix Paeoniae alba, and cortex et radix Polygalae into fine powder, sieving, and mixing; sieving to obtain coarse powder;

(b) taking radix scrophulariae, rhizoma polygonati, radix adenophorae, radix glehniae, radix pseudostellariae, acanthopanax, radix polygonati officinalis, cacumen biotae, pyrrosia lingua, radix semiaquilegiae, dark plum and radix stemonae, adding 10 times of water into the coarse powder obtained in the step (a), decocting for 2 times, 2.5 hours for the first time and 2 hours for the second time, and combining decoction;

(c) filtering the decoction obtained in the step (b), and concentrating the filtrate into thick paste with the relative density of 1.38 at 60 ℃;

(d) and (c) uniformly mixing the uniformly mixed medicine fine powder obtained in the step (a) and the thick paste obtained in the step (c), making pills, drying and polishing to obtain the traditional Chinese medicine composition concentrated pills.

Example 11:

a traditional Chinese medicine composition for treating chronic bronchitis is prepared from the following raw material medicines in parts by weight: 229g of changium smyrnioides, 229g of figwort root, 229g of steamed sealwort, 94g of adenophora tetraphylla, 94g of radix glehniae, 139g of radix pseudostellariae, 139g of acanthopanax senticosus, 94g of glossy privet fruit, 94g of radix polygonati officinalis, 94g of radix paeoniae alba, 49g of cacumen biotae, 49g of pyrrosia lingua, 49g of radix semiaquilegiae, 49g of polygala tenuifolia, 49g of dark plum fruit.

The Chinese medicinal composition is oral concentrated pill.

The preparation method of the traditional Chinese medicine composition concentrated pill for treating chronic bronchitis comprises the following specific steps:

(a) pulverizing radix Changii, fructus Ligustri Lucidi, radix Paeoniae alba, and cortex et radix Polygalae into fine powder, sieving, and mixing; sieving to obtain coarse powder;

(b) mixing radix scrophulariae, rhizoma Polygonati, radix Adenophorae, radix Glehniae, radix Pseudostellariae, radix Acanthopanacis Senticosi, rhizoma Polygonati Odorati, cacumen Platycladi, folium Pyrrosiae, radix Semiaquilegiae, mume fructus, and radix Stemonae with the coarse powder obtained in step (a), decocting with 9 times of water for 2 times, 2.5 hr for the first time and 2 hr for the second time, and mixing decoctions;

(c) filtering the decoction obtained in the step (b), and concentrating the filtrate into thick paste with the relative density of 1.39 at 60 ℃;

(d) and (c) uniformly mixing the uniformly mixed medicine fine powder obtained in the step (a) and the thick paste obtained in the step (c), making pills, drying and polishing to obtain the traditional Chinese medicine composition concentrated pills.

Example 12:

a traditional Chinese medicine composition for treating chronic bronchitis is prepared from the following raw material medicines in parts by weight: 230g of changium smyrnioides, 230g of figwort root, 230g of steamed sealwort, 95g of adenophora tetraphylla, 95g of radix glehniae, 140g of radix pseudostellariae, 140g of acanthopanax senticosus, 95g of glossy privet fruit, 95g of radix polygonati officinalis, 95g of radix paeoniae alba, 50g of cacumen biotae, 50g of pyrrosia lingua, 50g of radix semiaquilegiae, 50g of polygala tenuifolia, 50g of dark plum fruit.

The Chinese medicinal composition is oral concentrated pill.

The preparation method of the traditional Chinese medicine composition concentrated pill for treating chronic bronchitis comprises the following specific steps:

(a) pulverizing radix Changii, fructus Ligustri Lucidi, radix Paeoniae alba, and cortex et radix Polygalae into fine powder, sieving, and mixing; sieving to obtain coarse powder;

(b) decocting radix scrophulariae, rhizoma Polygonati, radix Adenophorae, radix Glehniae, radix Pseudostellariae, radix Acanthopanacis Senticosi, rhizoma Polygonati Odorati, cacumen Platycladi, folium Pyrrosiae, radix Semiaquilegiae, mume fructus, and radix Stemonae with 8 times of water for 2 times, 2.5 hr for the first time and 2 hr for the second time, and mixing decoctions;

(c) filtering the decoction obtained in the step (b), and concentrating the filtrate into thick paste with the relative density of 1.40 at 60 ℃;

(d) and (c) uniformly mixing the uniformly mixed medicine fine powder obtained in the step (a) and the thick paste obtained in the step (c), making pills, drying and polishing to obtain the traditional Chinese medicine composition concentrated pills.

Typical cases

Case 1

Zhang somewhere, woman, 75 years old, Zheng Zhou City, Henan province. The patient is hospitalized in the first subsidiary hospital of the university of traditional Chinese medicine in Henan for pneumonia and bronchitis in 1 month in 2015, and is discharged after improvement. Coughing and little white sticky phlegm appear after catching a cold in 2017, 3 and 7 days, accompanied by chest pain, dry mouth, dry throat and other symptoms, the discomfort is not improved after 1 week of spiramycin self-administration, and the medicine is stopped automatically without systemic treatment. No obvious inducement for aggravation of cough and little white sticky phlegm in 17 months in 2017 is caused, and the cough is accompanied by chest distress, chest pain, distending pain in the hypochondrium, nausea, poor appetite, dry mouth and throat, short breath, hypodynamia, capability of receiving food, poor sleep, normal stool and urine, red tongue with little coating and thready and rapid pulse. The body-checking shows that the lips are light red, the throat is congested, the tonsil is not swollen, the breathing sound of the two lungs is thick, the body-checking can be heard and dispersed in the fine wet gong sound, and the chest CT shows: inflammatory changes in both lungs, small cavities in the left inferior lung lobe, inflammatory changes were considered. The medicine of the invention in the embodiment 7 is taken 3 times a day, 6g once, and taken with warm boiled water. After taking the medicine for 4 days, the cough is relieved earlier, the chest distress, chest pain and dry mouth are obviously improved earlier, and the appetite and the sleep are normal. After the medicine is taken for 10 days, the patient occasionally has chest distress, no cough and expectoration, no mouth dryness and throat dryness, no other discomfort, and the subjective symptom is improved, and the patient is required to be discharged. After discharge, the drug of the invention example 7 is continuously taken for 1 week, and all follow-up visits are normal.

Case 2

Some Ju, woman, 66 years old, Zheng Zhou in Henan province. The patient has a medical history of chronic bronchitis for 10 years, the patient is hospitalized in our hospital for 3 months due to lumbago and backhip pain of 2 years in 2016 (4-month and 11-month), the patient complaints cough and expectoration in 2016 (4-month and 14-month without other discomfort, and the Jingdu Mianxi Sichuan fritillary and loquat ointment is orally taken for symptomatic treatment. The patient still coughs and expectorates in 2016, 4 months and 20 days, and the blood is checked conventionally: white blood cell 7.17X 10⁹L, lymphocyte fraction 14.9%, neutrophil fraction 75.3%, CT in lungs: 1. the upper lobes of the double lungs are old lesions, 2, lower lobes of the left lung are mild inflammation, 3, mediastinal lymph nodes are swollen, 4, pleura on both sides are thickened and adhered, and the history of the existing chronic bronchitis of a patient is considered, and the medicine is treated by using the medicine of the embodiment 8, wherein the medicine is taken 3 times a day, 6g is taken once, and the medicine is taken with warm water. After 1 week, the patient has no cough and expectoration and does not complain of other discomforts, and the patient is discharged after the waist pain symptom is improved in 2016, 4 and 30 days, and the patient is followed for 1 month without reciting the recurrence of the chronic bronchitis.

Case 3

Somebody in summer, a woman, 61 years old, people in Huayin city, province of Shaanxi. The patient has a history of chronic bronchitis for 40 years without systemic treatment, and is hospitalized in our hospital for 'waist and left lower limb pain for 4 years' in 2016, 9 and 21 days, and cough, dry cough without phlegm, fever and pharyngalgia appear in 2016, 9 and 23 days. The medicine of the invention in example 9 is taken 3 times a day by 6g once with warm water, the symptoms improve after 1 week, and the cough, fever and pharyngalgia are relieved and discharged from the hospital in 2016, 10 and 8 days. After discharge, the patient was followed up for 1 month without recurrence.

Case 4

Somebody of Wei, male, 66 years old, Shanxi county, Henan province. The patient has a history of chronic bronchitis for 20 years, and takes 2016 years of budesonide formoterol powder inhalation for Pinsu treatment. In 2016, 2 and 23 days, patients are treated in our hospital because of the symptoms of aggravated cough, little white sticky phlegm, dry mouth, short breath and hypodynamia. The medicine of the invention in the embodiment 10 is taken 3 times a day by 6g once with warm water, the symptoms of the patient are relieved after 1 week, the symptoms are controlled after the patient continues to take the medicine for 1 week, and the patient does not relapse after 1 month of follow-up visit.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various changes and modifications can be made without departing from the overall concept of the present invention, and these should also be considered as the protection scope of the present invention.

Claims (7)

1. A traditional Chinese medicine composition for treating chronic bronchitis is characterized in that: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 220-230 parts of changium smyrnioides, 220-230 parts of radix scrophulariae, 220-230 parts of rhizoma polygonati, 85-95 parts of adenophora tetraphylla, 85-95 parts of radix glehniae, 130-140 parts of radix pseudostellariae, 130-140 parts of acanthopanax senticosus, 85-95 parts of glossy privet fruit, 85-95 parts of radix polygonati officinalis, 85-95 parts of radix paeoniae alba, 40-50 parts of cacumen biotae, 40-50 parts of pyrrosia lingua, 40-50 parts of radix semiaquilegiae, 40-50 parts of polygala tenuifolia, 40-50 parts of dark plum and 40; rhizoma Polygonati is steamed rhizoma Polygonati, and radix Stemonae is honey radix Stemonae.

2. The traditional Chinese medicine composition for treating chronic bronchitis according to claim 1, wherein: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 222-228 parts of changium smyrnioides, 222-228 parts of radix scrophulariae, 222-228 parts of rhizoma polygonati, 87-93 parts of adenophora tetraphylla, 87-93 parts of radix glehniae, 132-138 parts of radix pseudostellariae, 132-138 parts of acanthopanax senticosus, 87-93 parts of glossy privet fruit, 87-93 parts of radix polygonati officinalis, 87-93 parts of radix paeoniae alba, 42-48 parts of cacumen biotae, 42-48 parts of pyrrosia lingua, 42-48 parts of radix semiaquilegiae, 42-48 parts of polygala tenuifolia, 42-48 parts of dark plum and 42.

3. The traditional Chinese medicine composition for treating chronic bronchitis according to claim 2, wherein: the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 225 parts of changium smyrnioides, 225 parts of radix scrophulariae, 225 parts of rhizoma polygonati, 90 parts of radix adenophorae, 90 parts of radix glehniae, 135 parts of radix pseudostellariae, 135 parts of acanthopanax, 90 parts of glossy privet fruit, 90 parts of radix polygonati officinalis, 90 parts of radix paeoniae alba, 45 parts of cacumen biotae, 45 parts of pyrrosia lingua, 45 parts of radix semiaquilegiae, 45 parts of polygala tenuifolia, 45 parts of dark plum fruit and 45 parts of.

4. The traditional Chinese medicine composition for treating chronic bronchitis according to any one of claims 1 to 3, wherein: the Chinese medicinal composition is an oral Chinese medicinal pill.

5. The traditional Chinese medicine composition for treating chronic bronchitis according to claim 4, wherein: the traditional Chinese medicine pill is water pill, honeyed pill, water honeyed pill or concentrated pill.

6. The traditional Chinese medicine composition for treating chronic bronchitis according to claim 5, wherein: the traditional Chinese medicine pill is a concentrated pill.

7. The method for preparing a Chinese medicinal composition concentrated pill for treating chronic bronchitis as claimed in claim 5, wherein: the method comprises the following specific steps:

(a) pulverizing radix Changii, fructus Ligustri Lucidi, radix Paeoniae alba, and cortex et radix Polygalae into fine powder, sieving, and mixing; sieving to obtain coarse powder;

(b) mixing radix scrophulariae, rhizoma Polygonati, radix Adenophorae, radix Glehniae, radix Pseudostellariae, radix Acanthopanacis Senticosi, rhizoma Polygonati Odorati, cacumen Platycladi, folium Pyrrosiae, radix Semiaquilegiae, mume fructus, and radix Stemonae with the coarse powder obtained in step (a), decocting with 8-10 times of water for 2 times, 2.5 hr for the first time and 2 hr for the second time, and mixing decoctions;

(c) filtering the decoction obtained in step (b), and concentrating the filtrate to obtain soft extract with relative density of 1.30-1.40 at 60 deg.C;

(d) and (c) uniformly mixing the uniformly mixed medicine fine powder obtained in the step (a) and the thick paste obtained in the step (c), making pills, drying and polishing to obtain the traditional Chinese medicine composition concentrated pills.