CN102973833A - Pharmaceutical composition for treating bronchitis - Google Patents
Pharmaceutical composition for treating bronchitis Download PDFInfo
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- CN102973833A CN102973833A CN2012105665040A CN201210566504A CN102973833A CN 102973833 A CN102973833 A CN 102973833A CN 2012105665040 A CN2012105665040 A CN 2012105665040A CN 201210566504 A CN201210566504 A CN 201210566504A CN 102973833 A CN102973833 A CN 102973833A
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Abstract
The invention relates to a pharmaceutical composition for treating bronchitis, which is prepared from active components and medicinal auxiliary materials, wherein the active components are prepared from the following traditional Chinese medicinal materials in parts by weight: 12-22 parts of dangshen, 16-22 parts of bighead atractylodes rhizome, 15-25 parts of liquorice, 15-25 parts of prepared dried orange peel, 10-16 parts of prepared pinellia tuber, 18-30 parts of Chinese yam, 12-20 parts of asparagus, 12-20 parts of rehmannia root, 12-20 parts of muskroot-like semiaquilegia root, 10-16 parts of astragalus root, 15-25 parts of angelica sinensis, 15-22 parts of stringy stonecrop, 15-25 parts of figwort root, 15-25 parts of cornel, 16-22 parts of self-heal, 15-22 parts of coastal glehnia root, 15-22 parts of cogongrass rhizome and 13-20 parts of oldenlandia diffusa. The pharmaceutical composition for treating bronchitis has the effects on relieving cough, reducing sputum and relieving asthma, inhibits common bacterial infection of the respiratory tract, and has notable therapeutic effects on bronchitic lesion.
Description
Technical field
The invention belongs to technical field of Chinese medicines, treat bronchitic pharmaceutical composition in particular to a kind of, relate in particular to a kind of pharmaceutical composition for the treatment of acute bronchitis.
Background technology
Bronchitis comprises two kinds of acute bronchitis and chronic bronchitiss.Acute bronchitis is a kind of common respiratory system disease, shows as the acute inflammation of trachea, bronchial mucosa.Clinical cardinal symptom has cough, expectoration; Thick or the doing of being dispersed in of chest health check-up two pulmonary respiration sounds, moist rale can disappear after the cough.Be easy to morbidity when winter or abrupt change of climate.Particularly being exposed to over a long time in smoke from cigarette and the atmospheric pollution environment, can causing a gas. the lasting infringement of bronchial tree, this and recurrent bronchitis also have certain relation.The most onsets of chronic bronchitis are very hidden, and it is special that the beginning symptom there is no except tussiculaing, so be difficult for being noted by patient.Before the some patients were onset medical histories such as acute upper respiratory tract infection such as acute pharyngolaryngitis, flu, acute bronchitis are arranged first, and originally many in morbidity cold season, later symptom is namely lasting, repeatedly outbreak.The main clinical manifestation of chronic bronchitis is cough, expectoration, asthma and recurrent respiratory tract infection.
The bronchitis main cause has formed bronchial chronic nonspecific inflammation for the repeated infection of virus and antibacterial.When there's a sudden fall in temperature, degradation is beneficial to pathogenic under the respiratory tract small blood vessel spasm ischemia, defense function; The chronic stimulations such as smog dust, atmosphere pollution also can be fallen ill; Smoking makes bronchospasm, mucosa variation, ciliary movement reduction, mucous secretion increase favourable infection; Irritated factor also has certain relation.
Because atmospheric pollution, smoker remain high, national physique constantly descends, the factors such as limitation of Western learning analytical thinking, often have the bronchitis patient repeatedly to show effect or protracted course of disease.The Supporting Therapy of as western medical treatment, at first suiting the medicine to the illness, or empirical application antibiotic, but still patient cough protracted course of disease or repeatedly outbreak are often arranged.Chinese medicine has its wide prospect.Zhang Jingyue was once advocated saying of " six gas all making us coughing, and wind and cold is main "." General Treatise on the Cause and Symptoms of Diseases " cloud " cough person, the lung sense is in cold, little person becomes cough also ".It is fallen ill in early days normal and experiences " outside cold-evil " important relationship, or enters from mouth and nose, or enters from fur, lung opening at nose closes fur outward, and is " tender dirty ", " three-character medical verses cough " piece of writing is said " lung must not be subjected to external courteous, courteous dried then choking and cough ".The strongly fragrant lung of cold-evil, gas is cloth Tianjin not, condenses to be expectorant.Its pathogenesis many and exogenous cold, phlegm-damp are disturbed lung, and impaired depurative descending of lung QI is relevant.Its clinical cardinal symptom has cough, expectoration, or accompanies uncomfortable in chest, tachypnea, tcm diagnosis mainly to consider " cough " or " asthma ".
In sum, seek the bronchitic medicine for the treatment of of a science safety, for the acute bronchitis protracted course of disease or repeatedly send out the author important realistic price is arranged.
Summary of the invention
The object of the present invention is to provide a kind of bronchitic pharmaceutical composition for the treatment of.This medical instrument has the relieving cough and resolving phlegm antiasthmatic effect, suppresses the infection of respiratory tract common bacteria, and the bronchus inflammatory lesion is had significant therapeutic effect.
The object of the present invention is achieved like this:
A kind ofly treat bronchitic pharmaceutical composition, comprise active component and pharmaceutic adjuvant, wherein said active component is prepared from by the Chinese crude drug of following weight portion: Radix Codonopsis 12-22 part, Rhizoma Atractylodis Macrocephalae 16-22 part, Radix Glycyrrhizae 15-25 part, Pericarpium Citri Reticulatae 15-25 part processed, Rhizoma Pinelliae Preparatum 10-16 part, Rhizoma Dioscoreae 18-30 part, Radix Asparagi 12-20 part, Radix Rehmanniae 12-20 part, Radix Semiaquilegiae 12-20 part, Radix Astragali 10-16 part, Radix Angelicae Sinensis 15-25 part, Herba Sedi 15-22 part, Radix Scrophulariae 15-25 part, Fructus Corni 15-25 part, Spica Prunellae 16-22 part, Radix Glehniae 15-22 part, Rhizoma Imperatae 15-22 part, Herba Hedyotidis Diffusae 13-20 part.
Preferably, the bronchitic pharmaceutical composition of above-mentioned treatment, wherein said active component is prepared from by the Chinese crude drug of following weight portion: Radix Codonopsis 15-20 part, Rhizoma Atractylodis Macrocephalae 16-20 part, Radix Glycyrrhizae 17-21 part, Pericarpium Citri Reticulatae 18-22 part processed, Rhizoma Pinelliae Preparatum 10-15 part, Rhizoma Dioscoreae 24-30 part, Radix Asparagi 14-18 part, Radix Rehmanniae 14-18 part, Radix Semiaquilegiae 14-18 part, Radix Astragali 10-14 part, Radix Angelicae Sinensis 18-22 part, Herba Sedi 16-20 part, Radix Scrophulariae 18-22 part, Fructus Corni 17-20 part, Spica Prunellae 16-20 part, Radix Glehniae 16-20 part, Rhizoma Imperatae 16-20 part, Herba Hedyotidis Diffusae 15-20 part.
Further preferably, the bronchitic pharmaceutical composition of above-mentioned treatment, wherein said active component is prepared from through water extraction by the Chinese crude drug of following weight portion: 18 parts of Radix Codonopsis, 18 parts of Rhizoma Atractylodis Macrocephalae, 19 parts of Radix Glycyrrhizae, 20 parts of Pericarpium Citri Reticulataes processed, 13 parts of Rhizoma Pinelliae Preparatum, 27 parts of Rhizoma Dioscoreaes, 16 parts of Radix Asparagis, 16 parts of Radix Rehmanniae, 16 parts of Radix Semiaquilegiaes, 12 parts of Radix Astragali, 20 parts of Radix Angelicae Sinensis, 18 parts of Herba Sedis, 20 parts of Radix Scrophulariaes, 18 parts of Fructus Corni, 18 parts of Spica Prunellaes, 20 parts of Radix Glehniaes, 20 parts of Rhizoma Imperataes, 18 parts of Herba Hedyotidis Diffusaes.
The bronchitic pharmaceutical composition for the treatment of of the present invention, it is made into oral formulations.Described oral formulations is preferably granule, tablet, oral liquid or capsule.
According to the Chinese medicine Historical Data Data About, above-mentioned Chinese crude drug has following pharmacologically active and function cures mainly:
Radix Codonopsis: invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the dyspnea due to deficiency cough, interior-heat is quenched one's thirst etc.Select the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf..
The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Select the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Select the Fisch. for dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensis, Glycyrrhiza inflata Bat. G.inflata Bat., or the root and rhizome of Glycyrrhiza glabra L. G.glabra L..
Pericarpium Citri Reticulatae: have regulating qi-flowing for strengthening spleen, in the accent, dampness, the effect of reducing phlegm.Cure mainly the distension and fullness in the abdomen of stagnation of QI in spleen and stomach or pain, dyspepsia.Abdominal distention uncomfortable in chest, indigestion and loss of appetite loose stool in the turbid damp resistance.Phlegm-damp is stopped up the cough and asthma of lung.Select the dry mature skin for rutaceae orange and variety thereof.
Rhizoma Pinelliae Preparatum: drying dampness to eliminate phlegm.Be used for the abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache.Select the tuber of the aroid Rhizoma Pinelliae (Pinellia ternata (Thunb) Breit.).
Rhizoma Dioscoreae: spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Be used for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.Select the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb..
Radix Asparagi: nourshing Yin and drynsessmoistening prescription; Lung heat clearing is promoted the production of body fluid.Be used for the treatment of cough caused by dryness-heat; Deficiency of YIN chronic cough; Consumption of YIN caused by febrile disease; Interior-heat is quenched one's thirst; The dryness of the intestine constipation; Laryngopharynx swelling and pain.Select the tuber of liliaceous plant Radix Asparagi (Radix Asparagi).
Radix Rehmanniae: clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid.Be used for calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.Fresh or dry tuber for Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch..
Radix Semiaquilegiae: heat-clearing and toxic substances removing; Dispersing swelling and dissipating binds; Relieving stranguria by diuresis.It is frightened to cure mainly children's's heat; Epilepsy; Carbuncle; Furuncle; Acute mastitis; Scrofula; The skin itching sore; Conjunctival congestion and swelling pain; Pharyngalgia; Snake bite and insect sting; Pyretic stranguria; Sand Stranguria.Select the dried root of ranunculaceae plant Radix Semiaquilegiae Semiaquilegiaadoxoides (DC.) Makino.
The Radix Astragali: have benefiting QI for strengthening the superficies, arresting sweating admittedly to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema.It is weak to be used for the treatment of the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating is given birth to consolidating superficial resistance holder skin ulcer.
Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Select the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.
Herba Sedi: eliminating damp-heat, detoxifcation.Be used for jaundice due to damp-heat, dysuria, carbuncle skin infection, acute hepatitis, chronic hepatitis.The effect of the glutamate pyruvate transaminase of reduction is arranged.The activeness that is used for acute hepatitis, chronic persistent hepatitis, chronic hepatitis.Select the fresh or dry herb of crassulaceae plants Herba Sedi Sedum sarmentosum Bunge.
Radix Scrophulariae: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing.Cure mainly pathogenic warmth and join the army, the pericardium that caves in, maculae caused by violent heat pathogen, constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin.Be selected from the dry root of dicotyledon Scrophulariaceae Scrophulariaceae Radix Scrophulariae Scrophularia ningpoensisHemsl..
Fructus Corni: liver and kidney tonifying, to restrain astringent or styptic treatment for spontaneous sweatingly, controlling nocturnal emission with astringent drugs reducing urination leukorrhagia stopping only collapses, and hidroschesis also has the promoting the production of body fluid to quench thirst effect in addition.Be used for the soreness of waist and knee joint dizziness and tinnitus, forgetful emission and spermatorrhea, enuresis frequent micturition, the bleeding not during menses menoxenia, the profuse sweating collapse, interior-heat is quenched one's thirst.Select the drying and ripening sarcocarp of Cornaceae plant Fructus Corni Cornus officinalis Sieb.et Zucc..
Spica Prunellae: liver heat removing, eliminating stagnation, diuresis; Control the diseases such as pestilence, acute mastitis, ophthalmalgia, jaundice, gonorrhea, hypertension; Leaf can be for tea.Control that lymphoid tuberculosis, thyromegaly, scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia are shed tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leukorrhagia.Select the dry fruit ear of dicotyledon Labiatae Labiatae Spica Prunellae Prunella vulgarisLinn..
Radix Glehniae: nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.It is thirsty to be used for lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound.Select the dry root of samphire glehnia littoralis Glehnia littoralis Fr.Schmidt ex Miq..
Rhizoma Imperatae: removing heat from blood, hemostasis, heat clearing away, diuresis.Control the calentura excessive thirst, spit blood epistaxis, lung-heat dyspnea with rapid respiration, gastric heat hiccup, gonorrhea, dysuria, edema, jaundice.Select the rhizome of grass Herba Imperatae lmperata cylindrica (L.) Beauv.var.major (Nees) C.K.Hubb.
Herba Hedyotidis Diffusae: latin name Herba Hedyotis Diffusae has the effect of heat-clearing and toxic substances removing, dampness removing; Cure mainly: dyspnea and cough due to lung-heat; Laryngopharynx swelling and pain; The intestinal carbuncle; The furuncle and phyma skin infection; Venom; The puckery pain of pyretic stranguria; Edema; Dysentery; Intestinal is scorching; Jaundice due to damp-heat; Cancerous protuberance.Be selected from the dry herb of Maguireothamnus speciosus Herba Hedyotidis Diffusae Hedyotis diffusa Willd..
The preparation technology that above-mentioned each Chinese crude drug is prepared into oral formulations comprises the steps: to take by weighing the various Chinese crude drugs of recipe quantity, cleans roguing, dries, and is ground into granule, mixes; Again above-mentioned graininess medical material is added water and cover powder, soak 1-1.5h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up the water that medical material 8-15 doubly measures for the first time, decoct 2h, get decocting liquid, filter, add up the water that medical material 6-10 doubly measures for the second time, decoct 2h, get twice decocting liquid and merge, filter, relative density is 1.20 concentrated solution when being concentrated into 90 ℃; Concentrated solution is put 4 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter; The filtrate reconcentration is contained 3-4g crude drug amount to every milliliter, add or do not add pharmaceutic adjuvant, get Chinese medicine oral liquid.Perhaps filtrate decompression being concentrated into relative density is 1.10-1.20, and with the concentrated solution spray drying, the gained granular powder is broken into dry extract, adds pharmaceutic adjuvant, the routinely agent of technique granulation, tablet or capsule.
Compared with prior art, when the Chinese medicine composition that the present invention relates to is used for the treatment of bronchitis, can obviously improve the bronchus inflammatory lesion, show that this medical instrument has the relieving cough and resolving phlegm antiasthmatic effect, suppress the infection of respiratory tract common bacteria, the bronchus inflammatory lesion is had significant therapeutic effect.
The specific embodiment
Further specify the present invention below by embodiment.Embodiments of the invention are only used for illustrating the present invention, rather than limitation of the present invention, and the simple modifications to preparation method of the present invention under design prerequisite of the present invention all belongs to the scope of protection of present invention.
The preparation of embodiment 1 Chinese medicine oral liquid
Crude drug prescription: Radix Codonopsis 180 grams, Rhizoma Atractylodis Macrocephalae 180 grams, Radix Glycyrrhizae 190 grams, Pericarpium Citri Reticulatae processed 200 grams, Rhizoma Pinelliae Preparatum 130 grams, Rhizoma Dioscoreae 270 grams, Radix Asparagi 160 grams, Radix Rehmanniae 160 grams, Radix Semiaquilegiae 160 grams, Radix Astragali 120 grams, Radix Angelicae Sinensis 200 grams, Herba Sedi 180 grams, Radix Scrophulariae 200 grams, Fructus Corni 180 grams, Spica Prunellae 180 grams, Radix Glehniae 200 grams, Rhizoma Imperatae 200 grams, Herba Hedyotidis Diffusae 180 grams.
Preparation technology: the Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae processed, Rhizoma Pinelliae Preparatum, Rhizoma Dioscoreae, Radix Asparagi, Radix Rehmanniae, Radix Semiaquilegiae, Radix Astragali, Radix Angelicae Sinensis, Herba Sedi, Radix Scrophulariae, Fructus Corni, Spica Prunellae, Radix Glehniae, Rhizoma Imperatae and the Herba Hedyotidis Diffusae that take by weighing recipe quantity, clean roguing, dry, be ground into granule, mix; Again above-mentioned graininess medical material is added water and cover powder, soak 1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up the water of 12 times of amounts of medical material for the first time, decoct 2h, get decocting liquid, filter, add up the water of 8 times of amounts of medical material for the second time, decoct 2h, get twice decocting liquid and merge, filter, relative density is 1.20 concentrated solution when being concentrated into 90 ℃; Concentrated solution is put 4 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter; The filtrate reconcentration is contained 3.5g crude drug amount to every milliliter, get Chinese medicine oral liquid.
The preparation of embodiment 2 Chinese medicine oral liquid
Crude drug prescription: Radix Codonopsis 220 grams, Rhizoma Atractylodis Macrocephalae 160 grams, Radix Glycyrrhizae 150 grams, Pericarpium Citri Reticulatae processed 250 grams, Rhizoma Pinelliae Preparatum 130 grams, Rhizoma Dioscoreae 200 grams, Radix Asparagi 120 grams, Radix Rehmanniae 190 grams, Radix Semiaquilegiae 120 grams, Radix Astragali 160 grams, Radix Angelicae Sinensis 160 grams, Herba Sedi 150 grams, Radix Scrophulariae 250 grams, Fructus Corni 220 grams, Spica Prunellae 220 grams, Radix Glehniae 150 grams, Rhizoma Imperatae 150 grams, Herba Hedyotidis Diffusae 150 grams.
Preparation technology: the Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae processed, Rhizoma Pinelliae Preparatum, Rhizoma Dioscoreae, Radix Asparagi, Radix Rehmanniae, Radix Semiaquilegiae, Radix Astragali, Radix Angelicae Sinensis, Herba Sedi, Radix Scrophulariae, Fructus Corni, Spica Prunellae, Radix Glehniae, Rhizoma Imperatae and the Herba Hedyotidis Diffusae that take by weighing recipe quantity, clean roguing, dry, be ground into granule, mix; Again above-mentioned graininess medical material is added water and cover powder, soak 1.5h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up the water of 10 times of amounts of medical material for the first time, decoct 2h, get decocting liquid, filter, add up the water of 6 times of amounts of medical material for the second time, decoct 2h, get twice decocting liquid and merge, filter, relative density is 1.20 concentrated solution when being concentrated into 90 ℃; Concentrated solution is put 4 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter; The filtrate reconcentration is contained 3.5g crude drug amount to every milliliter, get Chinese medicine oral liquid.
The preparation of embodiment 3 Chinese medicine oral liquid
Crude drug prescription: Radix Codonopsis 150 grams, Rhizoma Atractylodis Macrocephalae 200 grams, Radix Glycyrrhizae 250 grams, Pericarpium Citri Reticulatae processed 150 grams, Rhizoma Pinelliae Preparatum 160 grams, Rhizoma Dioscoreae 300 grams, Radix Asparagi 200 grams, Radix Rehmanniae 120 grams, Radix Semiaquilegiae 200 grams, Radix Astragali 100 grams, Radix Angelicae Sinensis 250 grams, Herba Sedi 220 grams, Radix Scrophulariae 150 grams, Fructus Corni 150 grams, Spica Prunellae 160 grams, Radix Glehniae 220 grams, Rhizoma Imperatae 220 grams, Herba Hedyotidis Diffusae 200 grams.
Preparation technology: the Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae processed, Rhizoma Pinelliae Preparatum, Rhizoma Dioscoreae, Radix Asparagi, Radix Rehmanniae, Radix Semiaquilegiae, Radix Astragali, Radix Angelicae Sinensis, Herba Sedi, Radix Scrophulariae, Fructus Corni, Spica Prunellae, Radix Glehniae, Rhizoma Imperatae and the Herba Hedyotidis Diffusae that take by weighing recipe quantity, clean roguing, dry, be ground into granule, mix; Again above-mentioned graininess medical material is added water and cover powder, soak 1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up the water of 12 times of amounts of medical material for the first time, decoct 2h, get decocting liquid, filter, add up the water of 8 times of amounts of medical material for the second time, decoct 2h, get twice decocting liquid and merge, filter, relative density is 1.20 concentrated solution when being concentrated into 90 ℃; Concentrated solution is put 4 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter; The filtrate reconcentration is contained 3.5g crude drug amount to every milliliter, get Chinese medicine oral liquid.
Embodiment 4 Chinese medicine oral liquid of the present invention are on the impact on mice chronic bronchitis model
The animal model method is that passive sulfur dioxide+Nicotiana tabacum L. replaces fumigation, amounts to 21d.SO2 modeling in morning every day: animal is put respectively in the people 4L closed box by group, produce SO2 with anhydrous sodium sulfite and sulfuric acid reaction, make the interior SO2 initial concentration of 4L closed box reach 0.09mg/ml, smoked 40min finishes, and mice is put back to raising; Afternoon every day, fumigation continued modeling: get tobacco shred 12g, and sawdust 12g, mixing ignition is put into airtight experiment cabinet 30min together with mice, has smoked cigarette at every turn mice is placed the ventilation.
With chronic bronchitis model mice random packet, and establish in addition Normal group, each group is gastric infusion (model group and Normal group are given with volume aquae destillata 10ml/kg, the Chinese medicine oral liquid 40ml/kg/d of the Chinese drug-treated group gavage embodiment of the invention 1 preparation) respectively, 1 time/d, continuous 15d.Behind the last administration 24h, put to death mice, clip trachea, bronchus are fixed with 10% formalin, routine paraffin wax embedding, HE dyeing, and the pathology inspection is done in the strip of tissue section.
Light microscopy checking molding result following (specifically referring to table 1):
Normal group: trachea, bronchial mucosa epithelium and wall tubular construction are normal.
Model group: trachea, the degeneration of bronchial mucosa visible part epithelium come off, the obvious hypertrophy of goblet cell, the flat or cubical epithelium of mucomembranous surface coating monolayer that has, obvious squamous metaplasia occurs in regional area, tube wall has more lymphocytic infiltration, the degeneration of bronchioles epithelium.
The treatment by Chinese herbs group: trachea, bronchial mucosa epithelium and wall pipe are slight chronic inflammatory pathological changes, and degree of inflammation all alleviates than model group, and the bronchioles epithelium is without obvious pathological changes.
Table 1 is respectively organized mice trachea, bronchus pathological changes situation
++ pathological changes is heavier; + pathological changes is lighter;-without obvious pathological changes
In addition, compare with the model group mice, the cough latent period time for the treatment of by Chinese herbs group mice obviously prolongs, cough frequency effectively reduces, sputum eliminating amount obviously increases, and can affirm that therefore Chinese medicine composition of the present invention has the antitussive of relievining asthma and the effect of eliminating the phlegm to Chronic Bronchitis Mice.
Claims (5)
1. treat bronchitic pharmaceutical composition for one kind, comprise active component and pharmaceutic adjuvant, it is characterized in that described active component is prepared from by the Chinese crude drug of following weight portion: Radix Codonopsis 12-22 part, Rhizoma Atractylodis Macrocephalae 16-22 part, Radix Glycyrrhizae 15-25 part, Pericarpium Citri Reticulatae 15-25 part processed, Rhizoma Pinelliae Preparatum 10-16 part, Rhizoma Dioscoreae 18-30 part, Radix Asparagi 12-20 part, Radix Rehmanniae 12-20 part, Radix Semiaquilegiae 12-20 part, Radix Astragali 10-16 part, Radix Angelicae Sinensis 15-25 part, Herba Sedi 15-22 part, Radix Scrophulariae 15-25 part, Fructus Corni 15-25 part, Spica Prunellae 16-22 part, Radix Glehniae 15-22 part, Rhizoma Imperatae 15-22 part, Herba Hedyotidis Diffusae 13-20 part.
2. the bronchitic pharmaceutical composition of described treatment according to claim 1, it is characterized in that: described active component is prepared from by the Chinese crude drug of following weight portion: Radix Codonopsis 15-20 part, Rhizoma Atractylodis Macrocephalae 16-20 part, Radix Glycyrrhizae 17-21 part, Pericarpium Citri Reticulatae 18-22 part processed, Rhizoma Pinelliae Preparatum 10-15 part, Rhizoma Dioscoreae 24-30 part, Radix Asparagi 14-18 part, Radix Rehmanniae 14-18 part, Radix Semiaquilegiae 14-18 part, Radix Astragali 10-14 part, Radix Angelicae Sinensis 18-22 part, Herba Sedi 16-20 part, Radix Scrophulariae 18-22 part, Fructus Corni 17-20 part, Spica Prunellae 16-20 part, Radix Glehniae 16-20 part, Rhizoma Imperatae 16-20 part, Herba Hedyotidis Diffusae 15-20 part.
3. the bronchitic pharmaceutical composition of described treatment according to claim 2, it is characterized in that: described active component is prepared from through water extraction by the Chinese crude drug of following weight portion: 18 parts of Radix Codonopsis, 18 parts of Rhizoma Atractylodis Macrocephalae, 19 parts of Radix Glycyrrhizae, 20 parts of Pericarpium Citri Reticulataes processed, 13 parts of Rhizoma Pinelliae Preparatum, 27 parts of Rhizoma Dioscoreaes, 16 parts of Radix Asparagis, 16 parts of Radix Rehmanniae, 16 parts of Radix Semiaquilegiaes, 12 parts of Radix Astragali, 20 parts of Radix Angelicae Sinensis, 18 parts of Herba Sedis, 20 parts of Radix Scrophulariaes, 18 parts of Fructus Corni, 18 parts of Spica Prunellaes, 20 parts of Radix Glehniaes, 20 parts of Rhizoma Imperataes, 18 parts of Herba Hedyotidis Diffusaes.
4. it is characterized in that according to claim 1 and 2 or the bronchitic pharmaceutical composition of 3 described treatments: it is oral formulations.
5. it is characterized in that according to claim 1 and 2 or the bronchitic pharmaceutical composition of 3 described treatments: it is granule, tablet, oral liquid or capsule.
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| CN201210566504.0A CN102973833B (en) | 2012-12-25 | 2012-12-25 | Pharmaceutical composition for treating bronchitis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104398889A (en) * | 2014-11-29 | 2015-03-11 | 高春娟 | Traditional Chinese medicine composition capable of expelling phlegm and arresting coughing and preparation method of traditional Chinese medicine composition |
| CN107582939A (en) * | 2017-10-26 | 2018-01-16 | 郑州中医骨伤病医院 | It is a kind of to be used to treat Chinese medicine composition of chronic bronchitis and preparation method thereof |
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| CN101711830A (en) * | 2009-12-14 | 2010-05-26 | 陈玲 | Traditional Chinese medicine composition for treating chronic bronchitis |
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| CN1245695C (en) * | 2003-09-15 | 2006-03-15 | 苏盛辉 | Type II public pin and code system based on level function |
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| CN1245695A (en) * | 1998-08-21 | 2000-03-01 | 马树昆 | Deodorant oral liquor |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398889A (en) * | 2014-11-29 | 2015-03-11 | 高春娟 | Traditional Chinese medicine composition capable of expelling phlegm and arresting coughing and preparation method of traditional Chinese medicine composition |
| CN107582939A (en) * | 2017-10-26 | 2018-01-16 | 郑州中医骨伤病医院 | It is a kind of to be used to treat Chinese medicine composition of chronic bronchitis and preparation method thereof |
| CN107582939B (en) * | 2017-10-26 | 2020-10-20 | 郑州中医骨伤病医院 | A Chinese medicinal composition for treating chronic bronchitis, and its preparation method |
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| CN102973833B (en) | 2014-08-13 |
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