CN108815376B - Throat-clearing and sore-throat-relieving tea - Google Patents
Throat-clearing and sore-throat-relieving tea Download PDFInfo
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- CN108815376B CN108815376B CN201810923246.4A CN201810923246A CN108815376B CN 108815376 B CN108815376 B CN 108815376B CN 201810923246 A CN201810923246 A CN 201810923246A CN 108815376 B CN108815376 B CN 108815376B
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- fire
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Abstract
The invention relates to a throat-clearing and sore-throat-relieving tea which is prepared from the following raw material medicines: radix Ophiopogonis, rhizoma Polygonati Odorati, semen Armeniacae amarum, flos Chrysanthemi, semen Scaphii Lychnophori, and herba Menthae. The invention also provides application of the traditional Chinese medicine in preparing a medicament for clearing throat and relieving sore throat. The advantages are that: 1. the invention mainly takes flowers, fruits and seeds as medicines, has dual purposes of medicine and food, is safe without side effect, and is suitable for being decocted to drink instead of tea. 2. The tea prepared by the invention can play an instant effect on swollen and red throat, pain, hoarseness, phlegm asthma and cough. 3. The components of the traditional Chinese medicines and the proportion of the components are screened through experiments, and the tea has the advantage of remarkable effect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a throat-clearing and sore-throat-relieving tea.
Background
With the acceleration of urbanization and industrial processes, the disordered discharge of pollutants such as industrial waste gas, automobile exhaust, coal dust and the like causes the pollutants such as dust, bacteria, viruses and inhalable particles in the air to be seriously overproof, and the pollutants are combined with fog to form haze weather, and in the weather, when people go out or in daily work and life, tiny particles (mainly particles with the diameter less than or equal to 2.5 micrometers, namely PM2.5) in the air can invade respiratory tracts and lung leaves of human bodies when people take precautions against the weather. After sulfur dioxide in haze components is inhaled into respiratory tracts by a human body, most of sulfur dioxide is blocked on the upper respiratory tracts due to easy water solubility, corrosive sulfurous acid is generated on wet mucous membranes, one part of sulfur dioxide is further oxidized into sulfuric acid, the stimulation effect is enhanced, if the human body inhales 100PPM sulfur dioxide every day, after 8 hours, the bronchus and the lung can have obvious stimulation symptoms to damage lung tissues, if the sulfur dioxide enters the deep layer of the lung of the human body, the toxicity is increased by 3-4 times, and the diseases such as fibroplasia of alveolar walls and the like are caused, and as the PM2.5 particles are small, the sulfur dioxide can easily enter the tissues such as the bronchus and the alveolus through the nasal cavities, the oral cavities and the throats of the human body to further cause the diseases of respiratory tract systems of the human body, such as sphagitis, allergy, asthma, rhinitis, nasosinusitis, emphysema and the like, Nasal obstruction, spouting, choking, dry throat and the like, and lung cancer, myocardial ischemia and injury can be induced to cause great harm to human bodies after being in the environment for a long time.
Pharyngolaryngitis is an inflammation of the mucous membrane of the throat and the tissues under the mucous membrane. According to the difference of the length of the disease course and the nature of pathological changes, the disease is divided into two major categories, namely acute pharyngitis and chronic pharyngitis. Acute pharyngitis is mainly caused by virus and germ infection or stimulation of various physical and chemical factors to cause acute congestion, swelling, pain and other inflammatory reactions of pharyngeal mucosa, submucosal tissues and lymphatic tissues. Chronic pharyngitis is diffuse inflammation of pharyngeal mucosa, submucosal tissues and lymphatic tissues caused by repeated attack of acute pharyngitis, oral and nasal diseases or long-term physical and chemical factor stimulation and various systemic chronic phlegm diseases. The symptoms are pharyngeal discomfort, dryness, foreign body sensation or mild pain, dry cough, nausea, pharyngeal congestion with dark red color, lymphatic bleb in the posterior pharyngeal wall and the like. Chronic pharyngitis patient often clears noise and spits white sputum because of the increase of pharyngeal secretion. The clinical symptoms of the traditional Chinese medicine include pharyngalgia, dry pharynx, fever, cough, expectoration, foreign body sensation, pharyngeal blockage, hoarseness, mouth opening, dysphagia and the like, the pharyngeal mucosa can be checked to show symptoms such as pharyngeal posterior wall lymphoproliferation, tonsil swelling, pharyngeal mucosa congestion and the like, and the incidence rate of the traditional Chinese medicine is extremely high in patients diagnosed in internal medicine, pediatrics and the department of five sense organs; it is more likely to recur for patients with acute and chronic bronchitis and bronchial asthma. Swelling and pain of gum and oral ulcer are the most common diseases in outpatient department of stomatology. The characteristics of the diseases bring physical and psychological pains to patients and inconvenience to life. Traditional Chinese medicine considers that the pharyngitis is characterized by throat, but the pathological formation of the pharyngitis is closely related to lung, liver, stomach and kidney. Therefore, some anti-inflammatory western medicines cannot be used for acute pharyngolaryngitis. The pathogenesis of chronic pharyngolaryngitis is that viscera deficiency damages, yin deficiency damages, deficient fire flaming up the throat, or repeated attack due to wind-heat pharyngitis, retention of residual pathogen, or dust, stimulation of foul breath, addiction to tobacco and wine, excessive strain and the like, lung yin deficiency causes fluid insufficiency, the throat fails to be nourished by soft-heat, and the deficient fire flaming up along the channels; kidney yin deficiency, the meridians of the kidney are connected to the lung, and yin deficiency of the lung also causes up-flaming of deficient fire, which leads to obstruction of the throat. In addition, the deficient fire steaming up and causing the body fluid to turn into phlegm, and the obstruction of the channels and collaterals and the obstruction of qi movement cause qi stagnation and phlegm coagulation and phlegm-fire stagnation. The throat is the mouth of the lung and stomach, for example, the lung and stomach have intrinsic heat, fire-heat flaming up, qi and blood stagnation in the throat, local chronic congestion can be seen, and the mucosa is dry and the disease is developed. In addition, the pharyngitis may occur due to kidney water deficiency, flaring up of deficient fire, dry throat and snoring. Western medicine has poor effect on treating the exterior by using multiple anti-inflammatory medicines for treating pharyngolaryngitis. The traditional Chinese medicine treatment focuses on conditioning lung, liver, stomach and kidney functions, focuses on treating the root causes, can eliminate the root causes of throat diseases, and has good treatment effect, so the traditional Chinese medicine treatment of the sphagitis has wide research space.
The Chinese patent application: CN102416093B discloses an anti-inflammatory and throat-benefiting traditional Chinese medicine composition taking wild buckwheat as a monarch drug, which comprises the following raw material medicines: 80-120 parts of radix scrophulariae; 60-100 parts of radix ophiopogonis; 80-120 parts of honeysuckle stem; 60-100 parts of blackberrykiky rhizome; 60-100 parts of scutellaria baicalensis; 100 portions of wild buckwheat rhizome and 150 portions of wild buckwheat rhizome; 60-80 parts of radix rehmanniae; 80-120 parts of laggera pterodonta; 60-100 parts of gypsum; 2-4 parts of menthol. It can be used for treating swelling and pain of throat caused by acute tonsillitis, angina or upper respiratory infection. The Chinese patent application: CN101229290A discloses a Chinese medicinal composition for treating common cold and sore throat and its preparing process, wherein the composition is prepared mainly from subprostrate sophora, isatis leaf, honeysuckle flower, belamcanda rhizome, arctium fruit, emblic leafflower fruit, oroxylum indicum, scrophularia root, mentha and licorice root, and has the functions of clearing away heat and toxic material, dispelling wind and heat, relieving sore throat and reducing swelling, nourishing yin and moistening lung, and can be used for treating fever and headache, common cold, sore throat and cough aphonia caused by affection of exogenous wind-heat or epidemic febrile disease, as well as acute pharyngitis and acute tonsillitis. However, no report is found about the throat clearing and sore throat relieving tea.
Disclosure of Invention
The first purpose of the invention is to provide a traditional Chinese medicine composition for clearing throat and relieving sore throat aiming at the defects of the prior art.
The second purpose of the invention is to provide the application of the traditional Chinese medicine composition for clearing throat and relieving sore throat aiming at the defects of the prior art.
The third purpose of the invention is to provide the throat-clearing and sore-throat-relieving tea aiming at the defects of the prior art.
In order to achieve the first purpose, the invention adopts the technical scheme that:
the traditional Chinese medicine composition for clearing throat and relieving sore throat is prepared from the following raw material medicines in parts by weight: 1-5 parts of dwarf lilyturf tuber, 1-3 parts of fragrant solomonseal rhizome, 1-3 parts of sweet almond, 0.5-1.5 parts of chrysanthemum flower from Hangzhou, 0.5-1.5 parts of boat-fruited sterculia seed and 0.5-1.5 parts of mint.
As a preferred scheme of the invention, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 3 parts of dwarf lilyturf tuber, 2 parts of fragrant solomonseal rhizome, 2 parts of sweet almond, 1 part of chrysanthemum flower from Hangzhou, 1 part of boat-fruited sterculia seed and 1 part of mint.
As a preferred scheme of the invention, the Chinese medicinal preparation is prepared into a clinically acceptable medicinal preparation according to a conventional Chinese medicinal preparation method.
As a preferable embodiment of the present invention, the pharmaceutical preparation is a granule, powder, capsule, tablet, mixture or oral liquid.
In order to achieve the second object, the invention adopts the technical scheme that:
the application of the traditional Chinese medicine composition in preparing the medicine for clearing throat and relieving sore throat.
In order to achieve the third object, the invention adopts the technical scheme that:
the throat-clearing and sore-throat-relieving tea is prepared by decocting the traditional Chinese medicine composition in water.
As a preferred scheme of the invention, the preparation method of the throat-clearing and sore-throat-relieving tea comprises the following steps:
(1) taking the raw materials according to the mixture ratio of claim 1, and decocting radix ophiopogonis, radix polygonati officinalis and sweet almond in water for 0.5-1.5 hours;
(2) adding flos Chrysanthemi and semen Scaphii Lychnophori, and decocting for 20-40 min;
(3) finally adding mint, boiling with strong fire, and decocting with slow fire for 15 minutes;
(4) and (4) leaching out juice, precipitating, taking clear liquid, and bottling for later use.
(5) The whole preparation process only needs to be decocted once.
As a preferred scheme of the invention, the preparation method of the throat-clearing and sore-throat-relieving tea comprises the following steps:
(1) selecting a pottery medicine decocting pot with proper size, adding 3 g of radix ophiopogonis, 2g of polygonatum odoratum and 2 sweet almonds, adding 1500 ml of water, boiling with strong fire, and decocting with slow fire for 0.5-1.5 hours;
(2) adding 1g of chrysanthemum and 1g of boat-fruited sterculia seed, boiling with big fire, and decocting with small fire for 20-40 minutes;
(3) finally, 1g of mint is added, the mixture is boiled with strong fire, and the mixture is decocted for 15 minutes with small fire;
(4) leaching out juice, precipitating, collecting clear liquid, and bottling;
(5) the whole preparation process only needs to be decocted once.
Radix Ophiopogonis has sweet and slightly bitter taste and cold nature, enters stomach, lung and heart channels, has effects of nourishing yin, moistening lung, benefiting stomach, promoting fluid production, clearing heart fire and relieving restlessness, and can be used as principal drug for treating pharyngitis, pharyngalgia, body fluid injury, thirst, internal heat, diabetes, vexation, insomnia, intestinal dryness and constipation etc. Ophiopogon japonicus has the functions of promoting the recovery of islet cell function, increasing hepatic glycogen and reducing blood sugar, and is listed as the superior product of nourishing yin and moistening lung in Shen nong Ben Cao Jing, which is said to be taken for a long time and light in weight, not old and hungry.
Yu Zhu is sweet and neutral and moist, and has the effects of nourishing yin, moistening dryness, promoting the production of body fluid and quenching thirst, although tonifying without hindering pathogenic factors. Compendium of materia Medica: its advantages are sure curative effect, agreeable nature, sweet taste and gentle taste. The book materia Medica is just written: the fragrant solomonseal rhizome, rhizoma Polygonati Odorati, a moist material, is the best herb for cultivating spleen-lung yin, but it is also effective for dispelling wind and dissipating heat, similar to non-moist sweet taste. It is also indicated for wind-heat and wind-warm syndrome due to deficiency.
Sweet almond: sweet and mild in nature and taste, and has the functions of moistening lung and relieving cough. It is mainly used for cough due to asthenia, pharyngalgia.
The polygonatum and the sweet almond are used as ministerial drugs and matched with the monarch drug of dwarf lilyturf tuber, so that the Chinese medicinal preparation has the effects of clearing lung and nourishing yin, and relieving sore throat and moistening throat.
The chrysanthemum is light in weight, soft and moist in quality, crisp when dried, fragrant in smell, sweet in taste and slightly bitter. Hangzhou chrysanthemum is pungent, sweet, bitter and slightly cold in nature. It enters lung and liver meridians. Has the effects of dispelling wind and heat, calming liver, improving eyesight, and clearing away heat and toxic materials. If the product is drunk frequently, the effects of spring warming and dehumidification, summer heat and thirst quenching, autumn dryness relieving and winter fire clearing can be achieved. It has effects of caring skin, replenishing blood, refreshing, enhancing vitality, and delaying aging.
Boat-fruited sterculia seed, sweet in taste, cool in nature and cold in nature. Has effects in removing toxic substance and relieving sore throat, and can be used for treating sore throat, xerostomia, dry throat, and gingival swelling and pain. And clearing lung-heat, resolving phlegm, relieving sore throat, relieving voice, moistening intestine and relaxing bowels. It can clear heat and moisten lung, and it can clear lung heat, treat dry cough without phlegm, thick phlegm and difficult expectoration. It is also indicated for the possibility of phlegm generation due to the action of Mai Dong.
The flos Chrysanthemi and semen Scaphii Lychnophori are used as adjuvant drugs.
The mint is a common Chinese medicine in China, young stem tips can be eaten as vegetables, and whole herbs can be used as medicines, so that the mint can be used for treating symptoms such as cold, fever, sore throat, headache, conjunctival congestion, muscle pain, pruritus due to skin rubella, measles imperviousness and the like.
The invention has the advantages that:
1. the invention mainly takes flowers, fruits and seeds as medicines, has dual purposes of medicine and food, is safe without side effect, and is suitable for being decocted to drink instead of tea.
2. The invention adopts a special preparation method according to the property of each Chinese medicament and carries out decoction preparation twice in sequence, thereby further ensuring the curative effect.
3. The whole tea drink prescription consists of natural herbal flowers, has aromatic smell, accurate and complete syndrome differentiation and good curative effect, is suitable for most people (pregnant women are not suitable) to take, and is also suitable for being taken for a long time.
5. The tea prepared by the invention can play an instant effect on swollen and red throat, pain, hoarseness, phlegm asthma and cough.
6. The components of the traditional Chinese medicines and the proportion of the components are screened through experiments, and the tea has the advantage of remarkable effect.
Detailed Description
The invention will be further illustrated with reference to specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, it should be understood that various changes and modifications can be made by those skilled in the art after reading the disclosure of the present invention, and equivalents fall within the scope of the appended claims.
EXAMPLE 1 throat-clearing and sore-throat-relieving traditional Chinese medicine composition 1
Taking the traditional Chinese medicine raw materials in proportion: 3 parts of dwarf lilyturf tuber, 2 parts of fragrant solomonseal rhizome, 2 parts of sweet almond, 1 part of chrysanthemum flower from Hangzhou, 1 part of boat-fruited sterculia seed and 1 part of mint.
EXAMPLE 2 throat-clearing and sore-throat-relieving Chinese medicinal composition (II)
Taking the traditional Chinese medicine raw materials in proportion: 1 part of dwarf lilyturf tuber, 1 part of fragrant solomonseal rhizome, 1 part of sweet almond, 1.5 parts of chrysanthemum flower from Hangzhou, 1.5 parts of boat-fruited sterculia seed and 1.5 parts of mint.
EXAMPLE 3 throat-clearing and sore-throat-relieving traditional Chinese medicine composition III
Taking the traditional Chinese medicine raw materials in proportion: 5 parts of dwarf lilyturf tuber, 3 parts of fragrant solomonseal rhizome, 3 parts of sweet almond, 0.5 part of chrysanthemum flower from Hangzhou, 0.5 part of boat-fruited sterculia seed and 0.5 part of mint.
Example 4 throat-clearing and sore-throat-relieving traditional Chinese medicine composition (IV)
Taking the traditional Chinese medicine raw materials in proportion: 1 part of dwarf lilyturf tuber, 3 parts of fragrant solomonseal rhizome, 1 part of sweet almond, 1.5 parts of chrysanthemum flower from Hangzhou, 0.5 part of boat-fruited sterculia seed and 1.5 parts of mint.
Example 5 throat-clearing and sore-throat-relieving traditional Chinese medicine composition (V)
Taking the traditional Chinese medicine raw materials in proportion: 5 parts of dwarf lilyturf tuber, 1 part of fragrant solomonseal rhizome, 3 parts of sweet almond, 0.5 part of chrysanthemum flower from Hangzhou, 1.5 parts of boat-fruited sterculia seed and 0.5 part of mint.
EXAMPLE 6 throat-clearing and sore-throat-relieving traditional Chinese medicine composition (VI)
Taking the traditional Chinese medicine raw materials in proportion: 2 parts of polygonatum odoratum, 2 parts of sweet almond, 1 part of chrysanthemum flower, 1 part of boat-fruited sterculia seed and 1 part of mint.
Example 7 preparation of decoction
The Chinese medicinal composition of any one of embodiments 1 to 5 is taken and added with water to be decocted according to a conventional method. The Chinese medicinal materials are taken according to the weight part ratio, and are decocted into decoction by adding water.
Example 8 preparation of tea for clearing throat and relieving sore-throat
(1) Selecting a pottery medicine decocting pot with proper size, adding 3 g of radix ophiopogonis, 2g of polygonatum odoratum and 2 sweet almonds, adding 1500 ml of water, boiling with strong fire, and decocting with slow fire for 0.5-1.5 hours;
(2) 1g of chrysanthemum and 1g of boat-fruited sterculia seed are added, and the mixture is boiled with big fire and decocted with small fire for 30 minutes;
(3) finally, 1g of mint is added, the mixture is boiled with strong fire, and the mixture is decocted for 15 minutes with small fire;
(4) leaching out juice, precipitating, collecting clear liquid, and bottling;
(5) the whole preparation process only needs to be decocted once.
EXAMPLE 9 preparation of granules
3 g of dwarf lilyturf tuber, 2g of fragrant solomonseal rhizome and 2 sweet almonds are taken, 1500 ml of water is added, the mixture is boiled with strong fire and decocted with small fire for 1 hour; adding 1g of chrysanthemum and 1g of boat-fruited sterculia seed, boiling with big fire, and decocting with small fire for 30 minutes; finally, 1g of mint is added, the mixture is boiled with strong fire and decocted for 15 minutes with small fire. Filtering, concentrating the filtrate, and cooling to room temperature; concentrating the supernatant, adding water, stirring, standing, and concentrating the supernatant into fluid extract. Taking the clear paste, and preparing into granules. The whole preparation process only needs to be decocted once.
EXAMPLE 10 preparation of tablets/capsules
3 g of dwarf lilyturf tuber, 2g of fragrant solomonseal rhizome and 2 sweet almonds are taken, 1500 ml of water is added, the mixture is boiled with strong fire and decocted with small fire for 1 hour; adding 1g of chrysanthemum and 1g of boat-fruited sterculia seed, boiling with big fire, and decocting with small fire for 30 minutes; finally, 1g of mint is added, the mixture is boiled with strong fire and decocted for 15 minutes with small fire. Filtering, concentrating the filtrate, and cooling to room temperature; taking supernatant, and concentrating to obtain thick extract; adding pharmaceutical adjuvants, vacuum drying, pulverizing, granulating, and making into tablet or capsule. The whole preparation process only needs to be decocted once.
Example 11 toxicity test
Experimental animals and groups
Experimental animals: 30 mice were purchased from Shanghai Slek Inc., half male and female, and weighing 20-22 g.
Grouping: the random number table method is adopted to divide the mice into 3 groups, each group comprises 10 mice, and the groups respectively comprise an experimental group, an experimental group and a control group.
Second, Experimental methods
The drugs prepared in the gavage example 1 of the mice in the experimental group and the normal gavage normal saline of the mice in the control group can not detect the LD of the gavage administration of the mice because of the limitation of the drug concentration and the administration route50The value is obtained. The maximum dose of the drug in the mouse is 120ml/kg per day, and the drug in the mouse is continuously administered for 90 days.
Third, detection method
Every 30 days, the blood routine, urine routine, liver and kidney functions of each group of mice were measured.
Fourth, experimental results
The long-term toxicity test result shows that: the bagged tea preparation is orally taken by 25g/kg, 16g/kg and 6g/kg for 90 days continuously, and compared with the control group of mice, the mice in the experimental group and the experimental group have no obvious influence on blood routine, urine routine, liver and kidney functions, no obvious change is found in the pathological examination of main organs, and no obvious difference is found in comparison with the blank control group.
Example 12 antitussive test
Experimental animals and groups
Experimental animals: 40 mice were purchased from Shanghai Slek Inc., half female and half, weighing 20-22 g.
Grouping: the random number table method is adopted to divide the mice into 4 groups, each group comprises 10 mice, and the groups respectively comprise an experimental group, an experimental group and a control group.
Second, Experimental methods
After fasting for 12 hours, the gavage dose of one group of mice is 8mg/20g of the traditional Chinese medicine composition prepared in the embodiment 1, the gavage dose of the other group of mice is 8mg/20g of the traditional Chinese medicine composition prepared in the embodiment 2, the gavage dose of the other group of mice is 8mg/20g of the traditional Chinese medicine composition prepared in the embodiment 6, and the gavage dose of the control group of mice is the same as the gavage dose of the normal saline. After 1 hour of administration, each group of mice was placed in a glass jar containing 1000ml of a solvent, concentrated ammonia water atomized by ultrasonic waves was sprayed into the glass jar for 5 seconds, the cough latency and the number of coughs in 2 minutes were observed immediately after the start of spraying, and the cough suppression rate was calculated.
Third, experimental results
The antitussive results for each group of mice are shown in table 1 below.
Cough latency refers to the time required for an ammonia spray to begin until a cough occurs.
The cough suppression rate (%) - (number of coughs in control group-number of coughs in experimental group)/number of coughs in control group ]. 100%
Table 1 results of antitussive effect (x ± s) (n ═ 10) for each group of mice
| Group of | Incubation period(s) | Number of coughs (times/2 min) | Inhibition ratio (%) |
| Experiment group | 50.1±0.3 | 18.3±1.1 | 87.5 |
| Two groups of experiments | 45.1±0.6 | 23.3±2.3 | 82.1 |
| Three groups of experiments | 40.2±0.5 | 25.4±5.5 | 81.3 |
| Control group | 26.1±3.6 | 59.6±7.2 |
The data results in table 1 show that: the data show that the medicine prepared by the raw material medicines and the mixture ratio has the best cough relieving effect.
Example 13 phlegm eliminating test
Experimental animals and groups
Experimental animals: 40 mice were purchased from Shanghai Slek Inc., half female and half, weighing 20-22 g.
Grouping: the random number table method is adopted to divide the mice into 4 groups, each group comprises 10 mice, and the groups respectively comprise an experimental group, an experimental group and a control group.
Second, Experimental methods
The gavage dose of one experimental group of mice is 8mg/20g of the medicine prepared in the embodiment 1, the gavage dose of two experimental groups of mice is 8mg/20g of the medicine prepared in the embodiment 2, the gavage dose of three experimental groups of mice is 8mg/20g of the medicine prepared in the embodiment 6, and the gavage dose of the control group of the same medical physiological saline is administrated 1 time a day for 3 days. After 1 hour of last administration, 1g/kg of urethane is anesthetized by intraperitoneal injection, and then the medicine is fixed in a supine position. Separating the trachea, pricking a small hole between two cartilages at the center of the lower edge of the thyroid cartilage by using a sharp injection needle, inserting one capillary glass tube into the small hole, enabling the capillary glass tube to just contact the bottom surface of the trachea, sucking the sputum by using the capillary glass tube, and taking the length of the sputum as the phlegm-resolving effect of the evaluation medicine. The secretion was observed and recorded for 2h in each mouse.
Third, experimental results
The expectorant effect of each group of mice is shown in table 2 below.
TABLE 2 phlegm-resolving effect of the mice in each group
| Group of | 2 hours sputum excretion (mm) |
| Experiment group | 32.2±0.1 |
| Two groups of experiments | 25.3±0.3 |
| Three groups of experiments | 22.3±0.5 |
| Control group | 11.2±2.3 |
The data in table 2 show that the traditional Chinese medicine composition has a good phlegm eliminating effect, wherein the effect of example 1 is the best.
EXAMPLE 14 clinical trial
First, data
1. General data
180 patients are selected from hospitals from 6 months to 2017 months in 2015 to visit in 8 months, and are divided into four groups by adopting a random number table method, wherein the four groups are respectively a treatment group, a treatment group and a control group. Before treatment, four groups of patients have no significant difference in sex, age, disease course and the like, and have good balance among the groups and comparability.
2. Diagnostic criteria
Chronic, aggravated, dark red, or dendritic congestion of the pharynx; proliferation of lymphatic follicles in the posterior pharyngeal wall, or enlargement of the lateral pharyngeal cord; the pharyngeal mucosa is hypertrophic or dry, atrophic, thinned, and attached with secretion. One or more symptoms of each of the above symptoms can be detected, i.e., pharyngitis can be diagnosed.
3. Inclusion criteria
(1) The pharyngitis diagnosis standard is met;
(2) the age is 18-60 years, and male and female are not limited;
(3) the subject signs an informed consent.
4 rejection criteria
Cases that were misincorporated without meeting inclusion criteria; cases that were not treated with the study protocol after inclusion, although meeting inclusion criteria; the abscission cases stopped in the middle of the test due to non-curative effect reasons and adverse reactions; adding other medicines; the data is not complete and cannot be counted.
5 termination and withdrawal of clinical trial criteria
Other diseases appear in the test, affecting the test performers; other situations are not foreseeable.
Second, method
1. Method of treatment
The treatment group was given the throat-clearing and sore-throat-relieving tea as follows: selecting a pottery medicine decocting pot with proper size, adding 3 g of radix ophiopogonis, 2g of polygonatum odoratum and 2 sweet almonds, adding 1500 ml of water, boiling with strong fire, and decocting with slow fire for 0.5-1.5 hours; 1g of chrysanthemum and 1g of boat-fruited sterculia seed are added, and the mixture is boiled with big fire and decocted with small fire for 30 minutes; finally, 1g of mint is added, the mixture is boiled with strong fire, and the mixture is decocted for 15 minutes with small fire; leaching out juice, precipitating, collecting clear liquid, and bottling; the whole preparation process only needs to be decocted once. The taking method comprises the following steps: one dose is taken every day, and a treatment course is 15 days after continuous taking. The treatment course is 2. The preparation method can also multiply at the same ratio, and can be used for preparing dosage for multiple days at one time, bottling, and placing into refrigerator for daily administration. The product can be taken with hot beverage, or after cooling, sealing with a cover, and heating with microwave oven. It can be taken in the morning, daytime and evening, before and after meal, or on empty stomach. Contraindications are as follows: 1, avoiding drinking wine, spicy diet and uncooked and cold diet. 2, it should be used with cautions for pregnant women.
The treatment groups were given the throat-clearing and sore-throat-relieving tea as follows: selecting a pottery medicine decocting pot with proper size, adding 5g of radix ophiopogonis, 3 g of radix polygonati officinalis and 3 sweet almonds, adding 1500 ml of water, boiling with strong fire, and decocting with slow fire for 0.5-1.5 hours; adding 0.5 g of chrysanthemum and 0.5 g of boat-fruited sterculia seed, boiling with big fire and decocting with small fire for 30 minutes; finally, putting 0.5 g of mint, boiling with strong fire, and decocting for 15 minutes with slow fire; leaching out juice, precipitating, collecting clear liquid, and bottling; the whole preparation process only needs to be decocted once. The taking method comprises the following steps: one dose is taken every day, and a treatment course is 15 days after continuous taking. The treatment course is 2. The preparation method can also multiply at the same ratio, and can be used for preparing dosage for multiple days at one time, bottling, and placing into refrigerator for daily administration. The product can be taken with hot beverage, or after cooling, sealing with a cover, and heating with microwave oven. It can be taken in the morning, daytime and evening, before and after meal, or on empty stomach. Contraindications are as follows: 1, avoiding drinking wine, spicy diet and uncooked and cold diet. 2, it should be used with cautions for pregnant women.
The throat-clearing tea described below was administered to three groups of patients: selecting a pottery medicine decocting pot with proper size, adding 2g of polygonatum odoratum and 2 sweet almonds, adding 1500 ml of water, boiling with strong fire, and decocting with slow fire for 0.5-1.5 hours; 1g of chrysanthemum and 1g of boat-fruited sterculia seed are added, and the mixture is boiled with big fire and decocted with small fire for 30 minutes; finally, 1g of mint is added, the mixture is boiled with strong fire, and the mixture is decocted for 15 minutes with small fire; leaching out juice, precipitating, collecting clear liquid, and bottling; the whole preparation process only needs to be decocted once. The taking method comprises the following steps: one dose is taken every day, and a treatment course is 15 days after continuous taking. The treatment course is 2. The preparation method can also multiply at the same ratio, and can be used for preparing dosage for multiple days at one time, bottling, and placing into refrigerator for daily administration. The product can be taken with hot beverage, or after cooling, sealing with a cover, and heating with microwave oven. It can be taken in the morning, daytime and evening, before and after meal, or on empty stomach. Contraindications are as follows: 1, avoiding drinking wine, spicy diet and uncooked and cold diet. 2, it should be used with cautions for pregnant women.
The control group was administered with Huasu tablets (manufactured by Beijing Huasu pharmaceutical Co., Ltd.) and kept in mouth for 1 tablet at a time, 3 times a day, and 15 consecutive days as a treatment course, 2 treatment courses were used in total.
2. Score criteria
(1) Dry throat and itching throat: occasionally feel dry and itchy throat, 2 points; dry throat and itching throat are often felt for 4 minutes; dry throat and itching throat exist continuously, affecting food intake in 6 minutes.
(2) Foreign body sensation in pharynx: occasionally, foreign body sensation in the pharynx, 2 points; there is often foreign body sensation in the pharynx, 4 points; foreign body sensation in the pharynx persists and affects the intake of food, 6 points.
(3) Pharyngeal burning sensation: occasionally, there is a burning sensation in the pharynx, 2 points; often there is a burning sensation in the pharynx, divided into 4 points; the burning sensation in the pharynx persists and affects the intake of food, 6 points.
(4) Pharyngeal mucosa: the pharyngeal mucosa has no thickening and no small vessel dilatation, but is dark red for 2 minutes; the pharyngeal mucosa has no thickening phenomenon, but has the small blood vessel expansion phenomenon, and is dark red for 4 minutes; the pharyngeal mucosa appeared thickened and small blood vessel dilated, and it was dark red, 6 minutes.
(5) Thick or purulent secretions behind the pharynx: occasionally, there are sticky or purulent secretions on the posterior pharyngeal wall, for 2 minutes; usually there are sticky or purulent secretions on the posterior pharyngeal wall, 4 minutes; the thick or purulent secretion persists behind the pharynx, affecting food intake for 6 minutes.
3. Criteria for therapeutic effect
The efficacy index (pre-treatment score-post-treatment score)/pre-treatment score was calculated from the pre-and post-treatment scores.
And (3) healing: after treatment, the integral value is reduced by more than 95%, and symptoms such as sore throat and the like disappear;
the effect is shown: the integral value is reduced by 70 to 95 percent after treatment, and the symptoms such as sore throat and the like are obviously improved;
the method has the following advantages: the integral value is reduced by 30 to 70 percent after treatment, and symptoms such as sore throat and the like are relieved;
and (4) invalidation: the integral value after treatment is reduced by less than 30 percent, and the symptoms such as sore throat and the like are not obviously improved.
Three, result in
The treatment results are shown in table 3 below.
TABLE 3 therapeutic Effect of the groups
The treatment results are shown in table 3, and the treatment results of a group of patients with 12 cure cases, 18 obvious effects, 10 effective cases and 2 ineffective cases show that the total effective rate is 95.24 percent; 10 cases are cured in two groups, 15 cases are obviously effective, 15 cases are effective, 6 cases are ineffective, the total effective rate is 86.96%, 11 cases are cured in three groups, 13 cases are obviously effective, 14 cases are effective, 8 cases are ineffective, and the total effective rate is 82.61%; the control group is cured by 5 cases, the obvious effect is 7 cases, the effective effect is 14 cases, the ineffective effect is 20 cases, and the total effective rate is 56.52%. The total effective rate of a group of the tea is obviously higher than that of a control group, which shows that the throat clearing and relieving tea has the obvious effect of treating pharyngitis. Compared with the treatment of one group and the treatment of two groups, the total effective rate of the treatment of one group is superior to that of the treatment of two groups, which shows that the traditional Chinese medicine composition has the advantage of remarkable pharyngitis treatment effect within a certain proportion range. Compared with the three groups of treatment, the total effective rate of the treatment of one group is better than that of the treatment of the three groups, which shows that the traditional Chinese medicine composition of the formula has obvious effect of treating pharyngitis.
Radix Ophiopogonis has sweet and slightly bitter taste and cold nature, enters stomach, lung and heart channels, has effects of nourishing yin, moistening lung, benefiting stomach, promoting fluid production, clearing heart fire and relieving restlessness, and can be used as principal drug for treating pharyngitis, pharyngalgia, body fluid injury, thirst, internal heat, diabetes, vexation, insomnia, intestinal dryness and constipation etc. Ophiopogon japonicus has the functions of promoting the recovery of islet cell function, increasing hepatic glycogen and reducing blood sugar, and is listed as the superior product of nourishing yin and moistening lung in Shen nong Ben Cao Jing, which is said to be taken for a long time and light in weight, not old and hungry.
Yu Zhu is sweet and neutral and moist, and has the effects of nourishing yin, moistening dryness, promoting the production of body fluid and quenching thirst, although tonifying without hindering pathogenic factors. Compendium of materia Medica: its advantages are sure curative effect, agreeable nature, sweet taste and gentle taste. The book materia Medica is just written: the fragrant solomonseal rhizome, rhizoma Polygonati Odorati, a moist material, is the best herb for cultivating spleen-lung yin, but it is also effective for dispelling wind and dissipating heat, similar to non-moist sweet taste. It is also indicated for wind-heat and wind-warm syndrome due to deficiency.
Sweet almond: sweet and mild in nature and taste, and has the functions of moistening lung and relieving cough. It is mainly used for cough due to asthenia, pharyngalgia.
The polygonatum and the sweet almond are used as ministerial drugs and matched with the monarch drug of dwarf lilyturf tuber, so that the Chinese medicinal preparation has the effects of clearing lung and nourishing yin, and relieving sore throat and moistening throat.
The chrysanthemum is light in weight, soft and moist in quality, crisp when dried, fragrant in smell, sweet in taste and slightly bitter. Hangzhou chrysanthemum is pungent, sweet, bitter and slightly cold in nature. It enters lung and liver meridians. Has the effects of dispelling wind and heat, calming liver, improving eyesight, and clearing away heat and toxic materials. If the product is drunk frequently, the effects of spring warming and dehumidification, summer heat and thirst quenching, autumn dryness relieving and winter fire clearing can be achieved. It has effects of caring skin, replenishing blood, refreshing, enhancing vitality, and delaying aging.
Boat-fruited sterculia seed, sweet in taste, cool in nature and cold in nature. Has effects in removing toxic substance and relieving sore throat, and can be used for treating sore throat, xerostomia, dry throat, and gingival swelling and pain. And clearing lung-heat, resolving phlegm, relieving sore throat, relieving voice, moistening intestine and relaxing bowels. It can clear heat and moisten lung, and it can clear lung heat, treat dry cough without phlegm, thick phlegm and difficult expectoration. It is also indicated for the possibility of phlegm generation due to the action of Mai Dong.
The flos Chrysanthemi and semen Scaphii Lychnophori are used as adjuvant drugs.
The mint is a common Chinese medicine in China, young stem tips can be eaten as vegetables, and whole herbs can be used as medicines, so that the mint can be used for treating symptoms such as cold, fever, sore throat, headache, conjunctival congestion, muscle pain, pruritus due to skin rubella, measles imperviousness and the like.
The invention mainly uses flowers, fruits and seeds, has dual purposes of medicine and food, is safe without side effect, and is suitable for being decocted to drink instead of tea; according to the invention, a special preparation method is adopted according to the medicinal properties of the traditional Chinese medicines, and the traditional Chinese medicine is prepared by decocting twice in sequence, so that the curative effect is further ensured; the whole tea drink prescription consists of natural herbal flowers, has aromatic smell, accurate and complete syndrome differentiation and good curative effect, is suitable for most people (pregnant women are not suitable) to take, and is also suitable for being taken for a long time; the tea prepared by the invention can play an instant effect on swollen and red throat, pain, hoarseness, phlegm asthma and cough; the components of the traditional Chinese medicines and the proportion of the components are screened through experiments, and the tea has the advantage of remarkable effect.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and additions can be made without departing from the principle of the present invention, and these should also be considered as the protection scope of the present invention.
Claims (7)
1. The traditional Chinese medicine composition for clearing throat and relieving sore throat is characterized by being prepared from the following raw material medicines in parts by weight: 3 parts of dwarf lilyturf tuber, 2 parts of fragrant solomonseal rhizome, 2 parts of sweet almond, 1 part of chrysanthemum flower from Hangzhou, 1 part of boat-fruited sterculia seed and 1 part of mint.
2. The traditional Chinese medicine composition of claim 1, which is prepared into a clinically acceptable pharmaceutical preparation according to a conventional traditional Chinese medicine preparation method.
3. The traditional Chinese medicine composition of claim 2, wherein the pharmaceutical preparation is a granule, a powder, a capsule, a tablet, a mixture or an oral liquid.
4. The use of the Chinese medicinal composition of claim 1 in the preparation of a medicament for clearing throat.
5. A tea for clearing throat and relieving sore throat, which is characterized in that the tea for clearing throat and relieving sore throat is prepared by decocting the traditional Chinese medicine composition of claim 1 in water.
6. The tea for clearing throat and relieving sore throat according to claim 5, which is prepared by the following steps:
(1) taking the raw materials according to the mixture ratio of claim 1, and decocting radix ophiopogonis, radix polygonati officinalis and sweet almond in water for 0.5-1.5 hours;
(2) adding flos Chrysanthemi and semen Scaphii Lychnophori, and decocting for 20-40 min;
(3) finally adding mint, boiling with strong fire, and decocting with slow fire for 15 minutes;
(4) leaching out juice, precipitating, collecting clear liquid, and bottling;
(5) the whole preparation process only needs to be decocted once.
7. The tea for clearing throat and relieving sore throat according to claim 5, which is prepared by the following steps:
(1) selecting a pottery medicine decocting pot with proper size, adding 3 g of radix ophiopogonis, 2g of polygonatum odoratum and 2 sweet almonds, adding 1500 ml of water, boiling with strong fire, and decocting with slow fire for 0.5-1.5 hours;
(2) adding 1g of chrysanthemum and 1g of boat-fruited sterculia seed, boiling with big fire, and decocting with small fire for 20-40 minutes;
(3) finally, 1g of mint is added, the mixture is boiled with strong fire, and the mixture is decocted for 15 minutes with small fire;
(4) leaching out juice, precipitating, collecting clear liquid, and bottling;
(5) the whole preparation process only needs to be decocted once.
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| CN1666674A (en) * | 2005-04-27 | 2005-09-14 | 邵建国 | Throat-protecting tea and preparation method thereof |
| CN101732558A (en) * | 2008-11-04 | 2010-06-16 | 戚寰 | Traditional Chinese medicine granules used for treating chronic pharyngitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1666674A (en) * | 2005-04-27 | 2005-09-14 | 邵建国 | Throat-protecting tea and preparation method thereof |
| CN101732558A (en) * | 2008-11-04 | 2010-06-16 | 戚寰 | Traditional Chinese medicine granules used for treating chronic pharyngitis |
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| Title |
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| 咽宁茶治疗干燥性咽炎42例;傅晓东等;《湖北中医杂志》;20011231;第23卷(第01期);33 * |
| 咽炎袋泡剂的制备与临床疗效观察;田晓燕等;《黑龙江医药》;19991231;第12卷(第06期);372-373 * |
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