CN103142870A - Pharmaceutical composition containing Herba Lopatheri - Google Patents
Pharmaceutical composition containing Herba Lopatheri Download PDFInfo
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- CN103142870A CN103142870A CN2011104016344A CN201110401634A CN103142870A CN 103142870 A CN103142870 A CN 103142870A CN 2011104016344 A CN2011104016344 A CN 2011104016344A CN 201110401634 A CN201110401634 A CN 201110401634A CN 103142870 A CN103142870 A CN 103142870A
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Abstract
The invention belongs to the technical field of medicine, and discloses an antitussive and a preparation method thereof. The medicament is prepared from the Herba Lopatheri, mulberry bark and loquat leaves. The medicament can be prepared into any clinically or pharmaceutically acceptable dosage form, preferably oral preparations. The medicament has efficacies of clearing lung, eliminating phlegm, and relieving sore throat and cough, and can be used for treating various cough, throat itch and pain.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of cough medicine and preparation method thereof.
Background technology
Cough is a kind of protectiveness respiratory reflex action of human body.The generation of cough is during due to the sensor in foreign body, irritative gas, respiratory tract endocrine etc. stimulate respiratory mucosa, gets excited and passes to the oblongata coughing centre by afferent nerve fiber, causes cough.The action of cough is very brief deeply air-breathing, and glottis closes, and respiratory muscle, Intercostal muscle and diaphram be fierce the contraction fast, makes the gas of lung inner high voltage spouting, just becomes cough.Along with the air-flow of going out rapidly, foreign body or secretions in respiratory tract are excreted.The traditional Chinese medical science is thought: cough is because of the diseases caused by exogenous pathogenic factor six climate exopathogens, and the internal organs internal injury affects the sound card that expectorant is arranged due to the lung.See " the Plain Questions the five internal organs generate a piece of writing "." Plain Questions pathogenesis gas should save one's life collection ": " cough meaning sound without expectorant, lung qi wound and also unclear; It is noiseless and expectorant arranged coughing, spleen wet moving and be expectorant also.Cough meaning has expectorant and sound, and it is wet that lid moves in spleen in lung qi due to wound, cough and for coughing also ".Because exopathogen is violated lung, or the internal organs internal injury, involve due to the lung.Doctor trained in Western medicine is thought: cough is a kind of protectiveness respiratory reflex action of human body.Can effectively remove the secretions in respiratory tract or enter the foreign body of air flue by coughre flex.But cough, disadvantageous one side is arranged also, violent cough can cause respiratory tract hemorrhage, and as for a long time, frequent, acutely coughing affects work, has a rest, and even causes laryngalgia, and hoarseness and breathing myalgia belong to pathological phenomenon.
At present, using the most effective cough medicine is depressor of nerve centre, can block the afferent conduction of coughre flex, cause the root of coughre flex because producing abnormal transmembrane potential but can not fundamentally eliminate injured neuronal cell surface, i.e. depressor of nerve centre treatment cough is cured the symptoms, not the disease.Therefore, remarkable in the urgent need to the research therapeutic effect, treating both the principal and secondary aspects of a disease, the Chinese medicine preparation that has no side effect.
Herba Lophatheri is the dry stem and leaf of grass Herba Lophatheri.Sweet in the mouth, light, cold in nature.GUIXIN, stomach, small intestine meridian.Cure mainly clearing heat and relieving fidgetness, diuresis.Be used for the calentura excessive thirst, hot urination drenches pain, aphtha of the mouth and tongue.
Cortex Mori is the dry root bark of moraceae plants Mulberry, and sweet in the mouth is cold in nature, returns lung meridian, cures mainly eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.Be used for dyspnea and cough due to lung-heat, edema distension oliguria, appearance skin edema.
Criticizing is leaf the leaf of dicotyledon medicine rosaceous plant Folium Eriobotryae, and bitter in the mouth is cool in nature, attaches to the lung and stomach meridians, and has cough-relieving, lung heat clearing stomach function regulating, lowering the adverse-rising QI to resolve phlegm effect.Cure mainly the lung-heat phlegmatic cough, hemoptysis, epistaxis, the gastric heat sound of vomiting of vomitting.
At present, utilize the interaction of Herba Lophatheri, Cortex Mori, Folium Eriobotryae, composition of prescription for the preparation of the itch medicine of pain for the treatment of various coughs, throat, there is not yet report.
Summary of the invention
In order to meet clinical needs, enlarge medicine variety, the invention provides that a kind of prescription science, preparation are simple, the cough medicine of determined curative effect and preparation method thereof.
The traditional Chinese medical science is thought: cough is because of the diseases caused by exogenous pathogenic factor six climate exopathogens, and the internal organs internal injury affects the sound card that expectorant is arranged due to the lung.See " the Plain Questions the five internal organs generate a piece of writing "." Plain Questions pathogenesis gas should save one's life collection ": " cough meaning sound without expectorant, lung qi wound and also unclear; It is noiseless and expectorant arranged coughing, spleen wet moving and be expectorant also.Cough meaning has expectorant and sound, and it is wet that lid moves in spleen in lung qi due to wound, cough and for coughing also ".Because exopathogen is violated lung, or the internal organs internal injury, involve due to the lung.
The present invention tries hard to from the angle of the traditional Chinese medical science take Herba Lophatheri, Cortex Mori, Folium Eriobotryae as primary raw material, provides a kind of drug formulation with antitussive effect, especially in the cough due to pathogenic wind-heat.
For this reason, drug main of the present invention will be made by the crude drug of following parts by weight:
Herba Lophatheri-10 part, Cortex Mori 4-8 part, Folium Eriobotryae 4-8 part.
Preferably, this medicine is made by the crude drug of following parts by weight:
8 parts of Herba Lophatheris, 6 parts of Cortex Mori, 6 parts of Folium Eriobotryaes.
The preparation method of said medicine comprises the following steps:
1) take Herba Lophatheri, Cortex Mori, the Folium Eriobotryae of described parts by weight, standby;
2) Herba Lophatheri, Cortex Mori, the Folium Eriobotryae that weighs up decocted with water together, merge extractive liquid, filters, and filtrate is concentrated into finite concentration, and precipitate with ethanol stirs, and cold preservation is standing, filters, and decompression filtrate recycling ethanol is to distinguishing the flavor of and be concentrated into thick paste without alcohol;
3) with above-mentioned thick paste oven dry, pulverize, get the active component of medicine of the present invention.
The preparation method of said medicine is preferably:
1) take Herba Lophatheri, Cortex Mori, the Folium Eriobotryae of described parts by weight, standby;
2) Herba Lophatheri, Cortex Mori, the Folium Eriobotryae that weighs up decocted with water secondary together, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1 hour, merge extractive liquid, filters, it is 1.15～1.20 that filtrate is concentrated into relative density, adding ethanol is 65% to containing the alcohol amount, stirs, and cold preservation is standing, filter, decompression filtrate recycling ethanol is to distinguishing the flavor of and be concentrated into thick paste without alcohol;
3) with above-mentioned thick paste oven dry, pulverize, get the active component of medicine of the present invention.
Medicine of the present invention has the effect of removing heat from the lung and dissipating phlegm, smooth throat to stop cough, itches bitterly for various coughs, throat, and effect is remarkable.
Medicine of the present invention can be mixed and made into clinically any or pharmaceutically acceptable dosage form, preferred oral preparation with one or more pharmaceutically acceptable carriers.When being applied in the mode of oral administration the patient who needs this treatment, can be made into conventional solid preparation, as tablet, capsule, soft capsule, dispersible tablet, chewable tablet, oral cavity disintegration tablet, oral liquid, granule, drop pill, slow releasing tablet, slow releasing capsule, controlled release tablet, controlled release capsule etc.
When medicine of the present invention is made preparation, the conventional method production in existing pharmaceutical field can be adopted, various pharmaceutically acceptable carriers can be added when needing.Described carrier comprises diluent, excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant of pharmaceutical field routine etc.
Medicine of the present invention is when making oral formulations, and selectable filler has: starch, Icing Sugar, calcium phosphate, calcium sulfate two water things, dextrin, microcrystalline Cellulose, lactose, pregelatinized Starch, mannitol etc.; Selectable binding agent has: complete sodium carboxymethylcellulose pyce, PVP-K30, through propyl cellulose, starch slurry, methylcellulose, ethyl cellulose, light the third methylcellulose, gelling starch etc.; Selectable disintegrating agent has: dried starch, polyvinylpolypyrrolidone, crosslinked sodium carboxymethylcellulose pyce, shuttle methyl starch sodium, the low light propyl cellulose etc. that replaces pressed; Selectable lubricant has: magnesium stearate, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.
The advantage of medicine of the present invention is:
(1) provide a kind of itch medicine of pain of various coughs and throat for the treatment of, increased the clinical application kind, satisfied clinical needs.
(2) pharmacological evaluation shows, medicine of the present invention has antitussive effect to the cough that mice ammonia causes, the eliminate the phlegm experimental result of experiment of phenol red method shows that medicine of the present invention has obvious phlegm-dispelling functions, clinical verification shows that Drug therapy laryngopharynx swelling and pain effect of the present invention is remarkable, and curative effect that medicine of the present invention reaches is that those of ordinary skills are beyond thought.
(3) pharmaceutical preparation of the present invention is simple, and between the different batches medicine, mass discrepancy is little, and drug quality is uniform and stable.
The specific embodiment of form, be described in further detail foregoing of the present invention by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following embodiment.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
The specific embodiment
The preparation of embodiment 1. tablets
Rhizoma Pinelliae 400g, Cortex Mori 300g, batch leaf 300g.
1) take Herba Lophatheri, Cortex Mori, the Folium Eriobotryae of described parts by weight, standby;
2) Herba Lophatheri, Cortex Mori, the Folium Eriobotryae that weighs up decocted with water secondary together, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1 hour, merge extractive liquid, filters, it is 1.15～1.20 that filtrate is concentrated into relative density, adding ethanol is 65% to containing the alcohol amount, stirs, and cold preservation is standing, filter, decompression filtrate recycling ethanol is to distinguishing the flavor of and be concentrated into thick paste without alcohol;
3) with above-mentioned thick paste oven dry, pulverize, get the active component of medicine of the present invention, add binding agent, disintegrating agent and lubricant granulation, drying is pressed into 1000.
The preparation of embodiment 2. capsules
Rhizoma Pinelliae 500g, Cortex Mori 200g, batch leaf 250g.
1) take Herba Lophatheri, Cortex Mori, the Folium Eriobotryae of described parts by weight, standby;
2) Herba Lophatheri, Cortex Mori, the Folium Eriobotryae that weighs up decocted with water secondary together, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1 hour, merge extractive liquid, filters, it is 1.15～1.20 that filtrate is concentrated into relative density, adding ethanol is 65% to containing the alcohol amount, stirs, and cold preservation is standing, filter, decompression filtrate recycling ethanol is to distinguishing the flavor of and be concentrated into thick paste without alcohol;
3) with above-mentioned thick paste oven dry, pulverize, get the active component of medicine of the present invention, add the binding agent granulation, dress up 1000 hard capsules.
The preparation of embodiment 3. granules
Rhizoma Pinelliae 500g, Cortex Mori 400g, batch leaf 200g.
1) take Herba Lophatheri, Cortex Mori, the Folium Eriobotryae of described parts by weight, standby;
2) Herba Lophatheri, Cortex Mori, the Folium Eriobotryae that weighs up decocted with water secondary together, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1 hour, merge extractive liquid, filters, it is 1.15～1.20 that filtrate is concentrated into relative density, adding ethanol is 65% to containing the alcohol amount, stirs, and cold preservation is standing, filter, decompression filtrate recycling ethanol is to distinguishing the flavor of and be concentrated into thick paste without alcohol;
3) with above-mentioned thick paste oven dry, pulverize, add Icing Sugar, binding agent to make 1000 bag granules.
Embodiment 4. antitussive effectiveness are observed
Experimental technique: 50 of mices, male and female half and half are divided into 5 groups at random, 10 every group.After fasting 6h, press medicine shown in table 1 and dosage gastric infusion 1 time.0.5h pneumoretroperitoneum injection 5% phenol red solution (0.5g/kg).0.5h after put to death animal, peel off the trachea surrounding tissue, cut one section trachea down to the trachea bifurcation from thyroid cartilage, put in the test tube that fills the 1ml normal saline, add again 0.1mLNaOH (1mmol/L), with 721 type spectrophotometers, wavelength 546nm, survey the OD value, calculate phenol red content.The results are shown in Table 1.
The impact of table 1 medicine of the present invention on the phenol red excretion of Respiratory Tract of Mice
Compare with matched group
△ △P＜0.01
By as seen from Table 1, the phenol red excretion of each dosage group trachea of medicine of the present invention is compared with matched group all significant differences.Illustrate that medicine of the present invention has obvious eliminating phlegm and relieving cough effect, and dose dependent is arranged, middle and high dose effect is better.
Claims (6)
1. an antitussive medicine, is characterized in that, this medicine is made by the crude drug of following parts by weight: Herba Lophatheri 6-10 part, Cortex Mori 4-8 part, Folium Eriobotryae 4-8 part.
2. according to claim 1, preferably, this medicine is made by the crude drug of following parts by weight: 8 parts of Herba Lophatheris, 6 parts of Cortex Mori, 6 parts of Folium Eriobotryaes.
3. the preparation method of the described medicine of claim 1-2, comprise the following steps:
1) take Herba Lophatheri, Cortex Mori, the Folium Eriobotryae of described parts by weight, standby;
2) Herba Lophatheri, Cortex Mori, the Folium Eriobotryae that weighs up decocted with water together, merge extractive liquid, filters, and filtrate is concentrated into finite concentration, and precipitate with ethanol stirs, and cold preservation is standing, filters, and decompression filtrate recycling ethanol is to distinguishing the flavor of and be concentrated into thick paste without alcohol;
3) with above-mentioned thick paste oven dry, pulverize, get the active component of medicine of the present invention.
4. the preparation method of according to claim 1-2 described medicines comprises the following steps:
1) take Herba Lophatheri, Cortex Mori, the Folium Eriobotryae of described parts by weight, standby;
2) Herba Lophatheri, Cortex Mori, the Folium Eriobotryae that weighs up decocted with water secondary together, add for the first time 10 times of amounts of water, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1 hour, merge extractive liquid, filters, it is 1.15～1.20 that filtrate is concentrated into relative density, adding ethanol is 65% to containing the alcohol amount, stirs, and cold preservation is standing, filter, decompression filtrate recycling ethanol is to distinguishing the flavor of and be concentrated into thick paste without alcohol;
3) with above-mentioned thick paste oven dry, pulverize, get the active component of medicine of the present invention.
5. according to claim 1-4 described medicines, is characterized in that, this medicine can be mixed and made into arbitrary preparation with pharmaceutically acceptable adjuvant.
6. according to claim 1-4 described medicines, is characterized in that, this medicine can be mixed and made into oral formulations with pharmaceutically acceptable adjuvant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104016344A CN103142870A (en) | 2011-12-07 | 2011-12-07 | Pharmaceutical composition containing Herba Lopatheri |
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| CN2011104016344A CN103142870A (en) | 2011-12-07 | 2011-12-07 | Pharmaceutical composition containing Herba Lopatheri |
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| CN103142870A true CN103142870A (en) | 2013-06-12 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104474335A (en) * | 2014-12-03 | 2015-04-01 | 大新县生产力促进中心 | Traditional Chinese medicine preparation for preventing and treating upper respiratory infection and preparation method of traditional Chinese medicine preparation |
| CN108720017A (en) * | 2018-06-11 | 2018-11-02 | 沈阳永大制药有限公司 | A kind of anti-fatigue health-product containing preparation process |
| CN111388617A (en) * | 2020-04-21 | 2020-07-10 | 广东一力罗定制药有限公司 | Traditional Chinese medicine composition for eliminating phlegm and relieving cough and preparation method thereof |
| CN115251452A (en) * | 2022-06-28 | 2022-11-01 | 深圳市艾普生物科技有限公司 | Atomized liquid for relieving cough and moistening lung and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104474335A (en) * | 2014-12-03 | 2015-04-01 | 大新县生产力促进中心 | Traditional Chinese medicine preparation for preventing and treating upper respiratory infection and preparation method of traditional Chinese medicine preparation |
| CN108720017A (en) * | 2018-06-11 | 2018-11-02 | 沈阳永大制药有限公司 | A kind of anti-fatigue health-product containing preparation process |
| CN111388617A (en) * | 2020-04-21 | 2020-07-10 | 广东一力罗定制药有限公司 | Traditional Chinese medicine composition for eliminating phlegm and relieving cough and preparation method thereof |
| CN115251452A (en) * | 2022-06-28 | 2022-11-01 | 深圳市艾普生物科技有限公司 | Atomized liquid for relieving cough and moistening lung and preparation method thereof |
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Application publication date: 20130612 |