CN100548358C - A kind of cough medicine - Google Patents
A kind of cough medicine Download PDFInfo
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- CN100548358C CN100548358C CNB2006100696579A CN200610069657A CN100548358C CN 100548358 C CN100548358 C CN 100548358C CN B2006100696579 A CNB2006100696579 A CN B2006100696579A CN 200610069657 A CN200610069657 A CN 200610069657A CN 100548358 C CN100548358 C CN 100548358C
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Abstract
The invention belongs to medical technical field, disclose a kind of cough medicine and preparation method thereof.This drug main will be prepared from for 2～20 parts by 2～20 parts in Semen Armeniacae Amarum, 5～25 parts of the Radixs Stemonae, 1～15 part of Lasiosphaera Seu Calvatia and Bombyx Batryticatus.It can be made into clinical or pharmaceutically acceptable arbitrary dosage form, preferred oral preparation.This medicine has the effect of removing heat from the lung and dissipating phlegm, smooth throat to stop cough, can be used for treating various coughs, the throat pain of itching.
Description
1, technical field
The invention belongs to medical technical field, be specifically related to a kind of cough medicine and preparation method thereof.
2, background technology
Cough is a kind of frequently-occurring disease and commonly encountered diseases, is the main clinic symptoms of diseases such as influenza, tracheitis, bronchitis.Cough is a kind of protectiveness respiratory tract reflection; be that respiratory tract is upset after (as inflammation, foreign body); send impulsion and import a kind of physiological reflex that the oblongata coughing centre causes into; can discharge respiratory secretions or foreign body; the cleaning of protection respiratory tract and unobstructed; therefore, cough generally is a kind of useful action, also sees healthy human body sometimes.In the ordinary course of things, to slightly and not frequent cough, as long as sputum or foreign body are discharged, just can natural remission, need not use cough medicine.But, to those no expectorant and violent dry cough, or expectorant is arranged and too frequent play is coughed, not only increase patient's misery, influence is had a rest and sleep, increases physical demands, even promotes the development of disease to produce other complication, and this moment is more harm than good.So, should suitably use cough medicine, with relieving cough.
At present, using the most effective cough medicine is depressor of nerve centre, can block the afferent conduction of coughre flex, but can not fundamentally eliminate injured neuronal cell surface because of producing the root that unusual transmembrane potential causes coughre flex, i.e. depressor of nerve centre treatment cough is cured the symptoms, not the disease.Therefore, it is remarkable to press for the research therapeutic effect, treating both the principal and secondary aspects of a disease, the Chinese medicine preparation that has no side effect.
Semen Armeniacae Amarum is the dry mature seed of rosaceous plant Prunus armeniaca L.var.ansu Maxim. Prunus armeniaca L.var.ansu Maxim., Siberia Fructus Pruni Prunus sibiricaL, prunus mandshuricaKoehne Prunus mandshurica (Maxim.) Koehne or Fructus Pruni Prunus armeniaca L..Hardship, tepor; Slightly poisonous.Return lung, large intestine channel.The sending down the abnormal ascending QI relieving cough and asthma is arranged, the effect of loosening bowel to relieve constipation.Be used for cough and asthma, the fullness in the chest abundant expectoration, blood deficiency Tianjin is withered.
The Radix Stemonae is the dried root of Stemonaceae plant Radix Stemonae Stemona sessilifolia (Miq.) Miq., Radix stemonae japonicae Stemona japonica (Bl.) Miq. or radix stemonae tuberosae Stemona tuberosa Lour..Sweet, bitter, tepor.Return lung meridian.The effect that nourishing the lung to keep the adverse QI downward cough-relieving is arranged.Be used for new chronic cough and cough, lung impairment and cough, pertussis.
Lasiosphaera Seu Calvatia is the dry sporophore of the grey bag fungus lasiosphaera fenzlii Reics Lasiosphaera fenzlii Reich. of section, calvatia gigantea Calvatia gigantea (Batschex Pers.) Lloyd or purple Lasiosphaera Seu Calvatia Calvatia Lilacina (Mont.et Berk.) Lloyd.Suffering, flat.Return lung meridian.The effect that removing heat from the lung and relieving sorethroat is arranged.Be used for the strongly fragrant lung pharyngalgia of wind heat, cough, hoarseness.Amplification on Canon of Materia Medica: " control the sore throat pharyngalgia." Compendium of Material Medica: " and lung heat clearing is analgesic, and the sore throat pharyngalgia is controlled in the blood cough-relieving of loosing, epistaxis, and aphonia, all skin ulcers are applied in external.”
Bombyx Batryticatus is that the larva in the insecticide silkworm Bombyx mori Linnaeus.4 of silkworm pretty young woman section～5 ages infects (or artificial vaccination) Bombyx Batryticatus Beauveria bassiana (Bals.) Vuillant. and lethal dry body.Salty, hot, flat.Return liver, lung, stomach warp.Expelling wind for relieving convulsion is arranged, the effect of dissipating phlegm and resolving masses.Be used for convulsion with spasms, laryngopharynx swelling and pain, submandibular lymph nodes inflammation.
At present, utilize the interaction of Semen Armeniacae Amarum, the Radix Stemonae, Lasiosphaera Seu Calvatia and Bombyx Batryticatus, composition of prescription is used to prepare the itch medicine of pain of the various coughs of treatment, throat, does not appear in the newspapers as yet.
3, summary of the invention
In order to meet clinical needs, enlarge medicine variety, the invention provides that a kind of prescription science, preparation are simple, the cough medicine of determined curative effect and preparation method thereof.
The traditional Chinese medical science is thought: lung the master give vent to anger, kidney governing inspiration, and cough caused by long-lasting diseases, not only the lung kidney is all empty, and middle burnt temper is stranded, the spleen being the source of producing phlegm, the lung being the utensil for storing phlegm, therefore abundant expectoration is seen in cough more, the full vexed disease of waiting of chest and diaphragm.
Semen Armeniacae Amarum is gone into lung meridian in the medicine of the present invention, and bitter in the mouth can fall, and hold concurrently to dredge the property that profit is opened, and falls to have the merit of lung qi dispersing concurrently among the lung qi and reach relieving cough and asthma, for controlling the key medicine of cough with asthma; The sweet profit hardship of the Radix Stemonae is fallen, and tepor is not dry, the special nourishing the lung to arrest cough of merit, no matter the diseases caused by exogenous pathogenic factor internal injury, cough cruelly, chronic cough, all available it; Both are we's monarch drug altogether; Lasiosphaera Seu Calvatia acrid in the mouth light weight is gone into lung meridian, can declare diffusing wind and heat in the lung meridian, and eliminating the pathogens from the lung is longer than resolving toxin and disinhibiting the throat through excess-fire clearly again, cooperates monarch drug, strengthens the treatment laryngopharynx swelling and pain, cough with aphonia's effect; The Bombyx Batryticatus wind-expelling pain-stopping, dissipating phlegm and resolving masses, the side of going into strengthens the effect of reducing phlegm.
Drug main of the present invention will be made by the crude drug of following parts by weight:
2～20 parts in Semen Armeniacae Amarum, 5～25 parts of the Radixs Stemonae, 1～15 part of Lasiosphaera Seu Calvatia, 2～20 parts of Bombyx Batryticatus.
The parts by weight of each component of medicine of the present invention are preferably:
5～15 parts in Semen Armeniacae Amarum, 8～20 parts of the Radixs Stemonae, 2～10 parts of Lasiosphaera Seu Calvatia, 5～15 parts of Bombyx Batryticatus.
The parts by weight of each component of medicine of the present invention are more preferably:
9 parts in Semen Armeniacae Amarum, 12 parts of the Radixs Stemonae, 6 parts of Lasiosphaera Seu Calvatia, 9 parts of Bombyx Batryticatus.
Manufacturing method for above mentioned medicine may further comprise the steps:
1) take by weighing Semen Armeniacae Amarum, the Radix Stemonae, Lasiosphaera Seu Calvatia and the Bombyx Batryticatus of described parts by weight, standby;
2) Semen Armeniacae Amarum, the Radix Stemonae and the Lasiosphaera Seu Calvatia that weighs up decocted with water together, merge extractive liquid, filters, and filtrate is concentrated into finite concentration, and precipitate with ethanol stirs, and cold preservation is left standstill, and filters, and decompression filtrate recycling ethanol is to not having the alcohol flavor and being concentrated into thick paste;
3) Bombyx Batryticatus that weighs up is added alcohol reflux, merge extractive liquid, filters, and filtrate recycling ethanol continues to be concentrated into thick paste to there not being the alcohol flavor;
4) merge above-mentioned two kinds of thick pastes, oven dry is pulverized, and gets the active component of medicine of the present invention.
Manufacturing method for above mentioned medicine is preferably:
1) take by weighing Semen Armeniacae Amarum, the Radix Stemonae, Lasiosphaera Seu Calvatia and the Bombyx Batryticatus of described parts by weight, standby;
2) Semen Armeniacae Amarum, the Radix Stemonae and the Lasiosphaera Seu Calvatia that weighs up decocted with water secondary together, add 10 times of amounts of water for the first time, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1 hour, merge extractive liquid, filters, it is 1.15～1.20 that filtrate is concentrated into relative density, adding ethanol is 65% to containing the alcohol amount, stirs, and cold preservation is left standstill, filter, decompression filtrate recycling ethanol is to not having the alcohol flavor and being concentrated into thick paste;
3) Bombyx Batryticatus that weighs up is added 60% alcohol reflux secondary, add 6 times of amounts of alcohol for the first time, refluxed 1.5 hours, add 4 times of amounts of alcohol for the second time, refluxed 1 hour, merge extractive liquid, filters, and filtrate recycling ethanol continues to be concentrated into thick paste to there not being the alcohol flavor;
4) merge above-mentioned two kinds of thick pastes, oven dry is pulverized, and gets the active component of medicine of the present invention.
The crude drug of medicine of the present invention is by weight as proportioning, can increase or reduce according to corresponding proportion when producing, and can kilogram be unit as large-scale production, or be unit with the ton that small-scale production also can restrain and be unit, and weight can increase or reduce.The weight proportion of medicine material medicine of the present invention obtains through science screening, and for especial patient, the ratio of can corresponding adjustment forming increases or reduce being no more than 100%.
Medicine of the present invention has the effect of removing heat from the lung and dissipating phlegm, smooth throat to stop cough, is used for various coughs, the throat pain of itching, and effect is remarkable.
Medicine of the present invention can be mixed and made into clinically any or pharmaceutically acceptable dosage form, preferred oral preparation with one or more pharmaceutically acceptable carriers.When being applied to the patient who needs this treatment in the mode of oral administration, can be made into conventional solid preparation, as tablet, capsule, soft capsule, dispersible tablet, chewable tablet, oral cavity disintegration tablet, oral liquid, granule, drop pill, slow releasing tablet, slow releasing capsule, controlled release tablet, controlled release capsule etc.
When medicine of the present invention is made preparation, the conventional method production in the existing pharmaceutical field can be adopted, various pharmaceutically acceptable carriers can be added when needing.Described carrier comprises diluent, excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant of pharmaceutical field routine etc.
Medicine of the present invention is when making oral formulations, and selectable filler has: starch, Icing Sugar, calcium phosphate, calcium sulfate two water things, dextrin, microcrystalline Cellulose, lactose, pregelatinized Starch, mannitol etc.; Selectable binding agent has: sodium carboxymethyl cellulose, PVP-K30, hydroxypropyl cellulose, starch slurry, methylcellulose, ethyl cellulose, hypromellose, gelling starch etc.; Selectable disintegrating agent has: dried starch, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose etc.; Selectable lubricant has: magnesium stearate, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.
The advantage of medicine of the present invention is:
(1) provides a kind of itch medicine of pain of various coughs and throat for the treatment of, increased the clinical application kind, satisfied clinical needs.
(2) pharmacological evaluation shows, medicine of the present invention has antitussive effect to the cough that mice ammonia causes, the eliminate the phlegm experimental result of experiment of phenol red method shows that medicine of the present invention has tangible phlegm-dispelling functions, clinical verification shows that Drug therapy laryngopharynx swelling and pain effect of the present invention is remarkable, and curative effect that medicine of the present invention reaches is that those of ordinary skills are beyond thought.
(3) pharmaceutical preparation of the present invention is simple, and mass discrepancy is little between the different batches medicine, and drug quality is uniform and stable.
Below routine by experiment beneficial effect of further setting forth the medicine of making by Semen Armeniacae Amarum, the Radix Stemonae, Lasiosphaera Seu Calvatia and Bombyx Batryticatus.
Experimental example 1: medicine of the present invention causes the influence of the effect of coughing to mice ammonia
Animal subject: Kunming mouse, male and female half and half, body weight 20 ± 2g.
Test sample: the basic, normal, high dosage group of medicinal granule of the present invention, self-control
Positive control drug: carbetapentane citrate tablet
Experimental technique: mice ammonia causes the method for coughing: 50 of mices, male and female half and half are divided into 5 groups at random, 10 every group.Behind the fasting 6h, press medicine shown in the table 1 and dosage gastric infusion 1 time.Behind the 1h, mice is put into holder, start aerosol apparatus, making mice accept ammonia stimulates, and to the scheduled time, closes aerosol apparatus, takes out mice immediately, observes cough number of times in the 1min.If the interior appearance of 1min is typical case's cough action (the abdominal muscle contraction or breast that contracts more than 3 times, magnify mouth simultaneously, sometimes audible is coughed sound) person can be regarded as " cough is arranged ", otherwise can be regarded as " not having cough ", press statistics " upward purgation (sequential method) " principle, change every mice and accept spray time, obtain the spray time (EDT that administration group and matched group cause that the half mouse cough is required
50).And, obtain the R value: R=administration group EDT by following formula
50/ matched group EDT
50* 100%.The result judges that evaluating medicine with the R value has or not antitussive effect and action intensity, all R values＞130%, and tentatively thinking has antitussive effect; R value＞150%, can think has obvious antitussive effect.The results are shown in Table 1.
Table 1 medicine of the present invention causes the influence of the effect of coughing to mice ammonia
Experimental result and conclusion:
By table 1 as seen, drug dose of the present invention be the R value of 1.5g/kg, 3g/kg, 6g/kg group distinguish＞130%,＞150%,＞150%, and the R value of medicine high dose group of the present invention is greater than the R value of carbetapentane citrate group.Show that medicine of the present invention has antitussive effect to the cough that mice ammonia causes, and dose dependent is arranged, middle and high dose effect is better.
Experimental example 2: medicine of the present invention is to the phenol red excretory influence in mouse breathing road
Animal subject: Kunming mouse, male and female half and half, body weight 20 ± 2g.
Test sample: the basic, normal, high dosage group of medicinal granule of the present invention, self-control
Ammonium chloride positive control drug group
Phenol red
Experimental technique: the phenol red method of experiment of eliminating the phlegm: 50 of mices, male and female half and half are divided into 5 groups at random, 10 every group.Behind the fasting 6h, press medicine shown in the table 2 and dosage gastric infusion 1 time.0.5h pneumoretroperitoneum is injected 5% phenol red solution (0.5g/kg).0.5h animal is put to death in the back, peel off the trachea surrounding tissue, cut one section trachea down to the trachea bifurcation from thyroid cartilage, put in the test tube that fills the 1ml normal saline, add 0.1mlNaOH (1mmol/L) again, with 721 type spectrophotometers, wavelength 546nm, survey the OD value, calculate phenol red content (μ g/ml).The results are shown in Table 2.
Table 2 medicine of the present invention is to the phenol red excretory influence in mouse breathing road (x ± s) (n=10)
Annotate: compare with matched group,
*P＜0.05,
*P＜0.01.
Experimental result and conclusion:
By table 2 as seen, the phenol red excretion of each dosage group trachea of medicine of the present invention is compared with matched group all has significance (p＜0.05, p＜0.01), and the phenol red excretion of medicine high dose group trachea of the present invention is higher than the ammonium chloride group, illustrate that medicine of the present invention has tangible phlegm-dispelling functions, and dose dependent is arranged, and middle and high dose effect is better.
Experimental example 3: clinical drug treatment laryngopharynx swelling and pain 66 routine observation of curative effect of the present invention
Physical data
66 routine patients, male's 39 examples, women's 27 examples; 3～14 years old 10 age example, 15～78 years old 56 example; The course of disease 1～45 day; Acute tonsillitis 21 examples wherein, chronic tonsillitis acute attack 15 examples, acute pharyngolaryngitis 22 examples, chronic pharyngolaryngitis acute attack 8 examples.
Diagnostic criteria
Recovery from illness: have sore throat and heating waits other simultaneous phenomenons to disappear;
Invalid: as to have sore throat and heating waits other simultaneous phenomenons not have improvement, need to cooperate the Western medicine antibiotic therapy.
Therapeutic outcome
This is organized in 66 examples, recovery from illness 48 examples in 3 days, 4～10 days recovery from illness 17 examples, invalid 1 example.Total effective rate 98.48%.
Conclusion:
Use checking through 66 routine patients, the total effective rate of treatment laryngopharynx swelling and pain is 98.48%, illustrates that medicine of the present invention has significant curative effect to the treatment laryngopharynx swelling and pain.
4, the specific embodiment
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following embodiment.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1: the preparation of medicinal tablet of the present invention
Semen Armeniacae Amarum 450g Radix Stemonae 600g Lasiosphaera Seu Calvatia 300g Bombyx Batryticatus 450g
1) take by weighing Semen Armeniacae Amarum, the Radix Stemonae, Lasiosphaera Seu Calvatia and the Bombyx Batryticatus of described parts by weight, standby;
2) Semen Armeniacae Amarum, the Radix Stemonae and the Lasiosphaera Seu Calvatia that weighs up decocted with water secondary together, add 10 times of amounts of water for the first time, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1 hour, merge extractive liquid, filters, it is 1.15～1.20 that filtrate is concentrated into relative density, adding ethanol is 65% to containing the alcohol amount, stirs, and cold preservation is left standstill, filter, decompression filtrate recycling ethanol is to not having the alcohol flavor and being concentrated into thick paste;
3) Bombyx Batryticatus that weighs up is added 60% alcohol reflux secondary, add 6 times of amounts of alcohol for the first time, refluxed 1.5 hours, add 4 times of amounts of alcohol for the second time, refluxed 1 hour, merge extractive liquid, filters, and filtrate recycling ethanol continues to be concentrated into thick paste to there not being the alcohol flavor;
4) merge above-mentioned two kinds of thick pastes, oven dry is pulverized, and gets the active component of medicine of the present invention, adds binding agent, disintegrating agent and lubricant and makes granule, and drying is pressed into 1000.
Embodiment 2: the preparation of medicine capsule of the present invention
Semen Armeniacae Amarum 450g Radix Stemonae 600g Lasiosphaera Seu Calvatia 300g Bombyx Batryticatus 450g
1) take by weighing Semen Armeniacae Amarum, the Radix Stemonae, Lasiosphaera Seu Calvatia and the Bombyx Batryticatus of described parts by weight, standby;
2) Semen Armeniacae Amarum, the Radix Stemonae and the Lasiosphaera Seu Calvatia that weighs up decocted with water secondary together, add 10 times of amounts of water for the first time, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1 hour, merge extractive liquid, filters, it is 1.15～1.20 that filtrate is concentrated into relative density, adding ethanol is 65% to containing the alcohol amount, stirs, and cold preservation is left standstill, filter, decompression filtrate recycling ethanol is to not having the alcohol flavor and being concentrated into thick paste;
3) Bombyx Batryticatus that weighs up is added 60% alcohol reflux secondary, add 6 times of amounts of alcohol for the first time, refluxed 1.5 hours, add 4 times of amounts of alcohol for the second time, refluxed 1 hour, merge extractive liquid, filters, and filtrate recycling ethanol continues to be concentrated into thick paste to there not being the alcohol flavor;
4) merge above-mentioned two kinds of thick pastes, oven dry is pulverized, and adds binding agent and makes granule, dresses up 1000 hard capsules.
Embodiment 3: the preparation of medicinal granule of the present invention
Semen Armeniacae Amarum 450g Radix Stemonae 600g Lasiosphaera Seu Calvatia 300g Bombyx Batryticatus 450g
1) take by weighing Semen Armeniacae Amarum, the Radix Stemonae, Lasiosphaera Seu Calvatia and the Bombyx Batryticatus of described parts by weight, standby;
2) Semen Armeniacae Amarum, the Radix Stemonae and the Lasiosphaera Seu Calvatia that weighs up decocted with water secondary together, add 10 times of amounts of water for the first time, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1 hour, merge extractive liquid, filters, it is 1.15～1.20 that filtrate is concentrated into relative density, adding ethanol is 65% to containing the alcohol amount, stirs, and cold preservation is left standstill, filter, decompression filtrate recycling ethanol is to not having the alcohol flavor and being concentrated into thick paste;
3) Bombyx Batryticatus that weighs up is added 60% alcohol reflux secondary, add 6 times of amounts of alcohol for the first time, refluxed 1.5 hours, add 4 times of amounts of alcohol for the second time, refluxed 1 hour, merge extractive liquid, filters, and filtrate recycling ethanol continues to be concentrated into thick paste to there not being the alcohol flavor;
4) merge above-mentioned two kinds of thick pastes, oven dry is pulverized, and adding Icing Sugar, binding agent are made 1000 bag granules.
Embodiment 4: the preparation of medicinal soft capsule of the present invention
Semen Armeniacae Amarum 360g Radix Stemonae 480g Lasiosphaera Seu Calvatia 240g Bombyx Batryticatus 360g
1) take by weighing Semen Armeniacae Amarum, the Radix Stemonae, Lasiosphaera Seu Calvatia and the Bombyx Batryticatus of described parts by weight, standby;
2) Semen Armeniacae Amarum, the Radix Stemonae and the Lasiosphaera Seu Calvatia that weighs up decocted with water secondary together, add 10 times of amounts of water for the first time, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1 hour, merge extractive liquid, filters, it is 1.15～1.20 that filtrate is concentrated into relative density, adding ethanol is 65% to containing the alcohol amount, stirs, and cold preservation is left standstill, filter, decompression filtrate recycling ethanol is to not having the alcohol flavor and being concentrated into thick paste;
3) Bombyx Batryticatus that weighs up is added 60% alcohol reflux secondary, add 6 times of amounts of alcohol for the first time, refluxed 1.5 hours, add 4 times of amounts of alcohol for the second time, refluxed 1 hour, merge extractive liquid, filters, and filtrate recycling ethanol continues to be concentrated into thick paste to there not being the alcohol flavor;
4) merge above-mentioned two kinds of thick pastes, oven dry is pulverized, the active component of medicine of the present invention, with soybean oil and soybean phospholipid, Cera Flava heating and melting, mixing is put coldly, adds the gained active component, is pressed into 1000 soft capsules.
Embodiment 5: the preparation of medicinal dropping ball of the present invention
Semen Armeniacae Amarum 270g Radix Stemonae 360g Lasiosphaera Seu Calvatia 180g Bombyx Batryticatus 270g
1) take by weighing Semen Armeniacae Amarum, the Radix Stemonae, Lasiosphaera Seu Calvatia and the Bombyx Batryticatus of described parts by weight, standby;
2) Semen Armeniacae Amarum, the Radix Stemonae and the Lasiosphaera Seu Calvatia that weighs up decocted with water secondary together, add 10 times of amounts of water for the first time, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1 hour, merge extractive liquid, filters, it is 1.15～1.20 that filtrate is concentrated into relative density, adding ethanol is 65% to containing the alcohol amount, stirs, and cold preservation is left standstill, filter, decompression filtrate recycling ethanol is to not having the alcohol flavor and being concentrated into thick paste;
3) Bombyx Batryticatus that weighs up is added 60% alcohol reflux secondary, add 6 times of amounts of alcohol for the first time, refluxed 1.5 hours, add 4 times of amounts of alcohol for the second time, refluxed 1 hour, merge extractive liquid, filters, and filtrate recycling ethanol continues to be concentrated into thick paste to there not being the alcohol flavor;
4) merge above-mentioned two kinds of thick pastes, oven dry is pulverized, get the active component of medicine of the present invention,, treat to add the gained active component after whole fusions polyethylene glycol 6000 heating and melting in water-bath, stirring and dissolving, 60 mesh sieves are filtered, and keep 60 ℃ to splash in the liquid paraffin that is chilled to below 10 ℃ and make ball.
Claims (5)
1. an antitussive medicine is characterized in that, this medicine is made by the crude drug of following parts by weight:
9 parts in Semen Armeniacae Amarum, 12 parts of the Radixs Stemonae, 6 parts of Lasiosphaera Seu Calvatia, 9 parts of Bombyx Batryticatus.
2. the preparation method of the described medicine of claim 1 comprises the following steps:
1) take by weighing Semen Armeniacae Amarum, the Radix Stemonae, Lasiosphaera Seu Calvatia and the Bombyx Batryticatus of described parts by weight, standby;
2) Semen Armeniacae Amarum, the Radix Stemonae and the Lasiosphaera Seu Calvatia that weighs up decocted with water together, merge extractive liquid, filters, and filtrate is concentrated into finite concentration, and precipitate with ethanol stirs, and cold preservation is left standstill, and filters, and decompression filtrate recycling ethanol is to not having the alcohol flavor and being concentrated into thick paste;
3) Bombyx Batryticatus that weighs up is added alcohol reflux, merge extractive liquid, filters, and filtrate recycling ethanol continues to be concentrated into thick paste to there not being the alcohol flavor;
4) merge above-mentioned two kinds of thick pastes, oven dry is pulverized, and gets the active component of medicine of the present invention.
3. the preparation method of medicine according to claim 2 may further comprise the steps:
1) take by weighing Semen Armeniacae Amarum, the Radix Stemonae, Lasiosphaera Seu Calvatia and the Bombyx Batryticatus of described parts by weight, standby;
2) Semen Armeniacae Amarum, the Radix Stemonae and the Lasiosphaera Seu Calvatia that weighs up decocted with water secondary together, add 10 times of amounts of water for the first time, decocted 2 hours, add for the second time 8 times of amounts of water, decocted 1 hour, merge extractive liquid, filters, it is 1.15～1.20 that filtrate is concentrated into relative density, adding ethanol is 65% to containing the alcohol amount, stirs, and cold preservation is left standstill, filter, decompression filtrate recycling ethanol is to not having the alcohol flavor and being concentrated into thick paste;
3) Bombyx Batryticatus that weighs up is added 60% alcohol reflux secondary, add 6 times of amounts of alcohol for the first time, refluxed 1.5 hours, add 4 times of amounts of alcohol for the second time, refluxed 1 hour, merge extractive liquid, filters, and filtrate recycling ethanol continues to be concentrated into thick paste to there not being the alcohol flavor;
4) merge above-mentioned two kinds of thick pastes, oven dry is pulverized, and gets the active component of medicine of the present invention.
4. according to the described medicine of claim 1, it is characterized in that this medicine can be made arbitrary preparation with mixing acceptable accessories.
5. medicine according to claim 1 is characterized in that this medicine can be made oral formulations with mixing acceptable accessories.
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