CN100563706C - A kind of pharmaceutical composition that is used for infantile diarrhea - Google Patents
A kind of pharmaceutical composition that is used for infantile diarrhea Download PDFInfo
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Abstract
The invention belongs to medical technical field, disclose a kind of pharmaceutical composition that is mainly used in infantile diarrhea and preparation method thereof.This pharmaceutical composition mainly is prepared from by certain weight proportion by Herba Sarcandrae, Pericarpium Granati and carbonized Rhizoma Zingiberis (processed).It can be made into clinical or pharmaceutically acceptable arbitrary dosage form, preferred oral preparation.This pharmaceutical composition has the poison of dispelling and holds back intestinal, warming spleen and stopping diarrha effect, can be used for infantile diarrhea, and is especially effective to infantile autumn diarrhea.
Description
1, technical field
The invention belongs to medical technical field, particularly a kind of pharmaceutical composition that is mainly used in infantile diarrhea, this pharmaceutical composition is mainly made by Herba Sarcandrae, Pericarpium Granati and carbonized Rhizoma Zingiberis (processed).
2, background technology
Infantile diarrhea is a kind of digestive tract syndrome, all can take place throughout the year, but the most multiple with summer and autumn especially.Rotavirus enteritis is caused by rotavirus that mainly next has Calicivirus, Astrovirus etc.Virus invades the Epithelium of intestinal villus cell, causes crypts and gland nest cell dysfunction, causes secretion and malabsorption diarrhoea.Belong to the traditional Chinese medical science diseases caused by exogenous pathogenic factor category of having loose bowels.The traditional Chinese medical science think have loose bowels originally be taste, stomach is a reservoir of food and drink, main being received, the spleen is the source of growth and development, main fortuneization is precise and tiny, ascending the clear and descending the turbid.Spleen and stomach function is healthy and vigorous, and then digest, absorb, transmit normally, but precise and tiny activating QI hemopoietic.Because it is imperfect that the spleen and stomach in children is grown, and mostly be the only child, the head of a family too spoils, and gives a large amount of high protein, high heat, nondigestible food, has increased the burden of taste on the contrary, causes water instead for wet, Gu Fanwei stagnate, and water paddy is regardless of, and walks large intestine and have loose bowels.
Still there is not the specific treatment method for infantile autumn diarrhea, it is comparatively general that antibiotic is used in treatment at present, but it is invalid mostly to treat, Chinese patent medicine is quite a few, and as " infantile diarrhea electuary ", " infantum tetanus is loose " etc., but the most onset speed of these medicines is slow, therapeutic effect is not obvious, so it is little to press for the exploitation toxic and side effects, eutherapeutic Chinese medicine.
Herba Sarcandrae is the dry Herb of gold chestnut orchid Herba Pileae Scriptae Sarcandra glabra (Thunb.) Nakai.Bitter in the mouth, suffering, property is flat.GUIXIN, Liver Channel.Clearing away heat and cooling blood is arranged, the speckle removing of invigorating blood circulation, the effect of dispelling wind and removing obstruction in the collateral.Be used for heat in blood purpura, purpura, rheumatic arthralgia, traumatic injury.Modern pharmacological research proves that Herba Sarcandrae has effects such as human body immunity improving power, resisting pathogenic microbes, anti-gastric-ulcer.
Pericarpium Granati is the dry peel of Punicaceae plant Punica granatum L. Punica granatum L..Sour in the mouth, puckery, warm in nature.Return large intestine channel.Relieving diarrhea with astringents is arranged, hemostasis, the effect of anthelmintic.Be used for chronic diarrhea, chronic dysentery is had blood in stool, proctoptosis, metrorrhagia, leucorrhea, abdominal pain due to worm stagnation.Compendium of Material Medica meaning: " ending dysentery hematochezia, proctoptosis, metrorrhagia, leukorrhagia ".Modern age is clinical all effective in order to treat acute and chronic dysentery.
Rhizoma Zingiberis Recens is the fresh rhizome of zingiber Zingiber officinale Rosc..Rhizoma Zingiberis is that the perennial root of Rhizoma Zingiberis Recens digs out that afterwash impurity section is dried or the low baking temperature oven dry forms.Carbonized Rhizoma Zingiberis (processed) is that Rhizoma Zingiberis is put the fiery big gun that blows slowly of going up to the burned black heart, but still the tool bulk.Acrid in the mouth, hot in nature.Return spleen, stomach, kidney, the heart, lung meridian.Warming spleen and stomach for dispelling cold is arranged, the effect of warming the meridian for stopping bleeding.Be used for Deficiency and coldness of spleen and stomach, stomachache is vomited and diarrhoea, and tells the nosebleed metrorrhagia, and yang deficiency is lost blood.
At present, utilize Herba Sarcandrae, Pericarpium Granati and carbonized Rhizoma Zingiberis (processed) interaction, composition of prescription, be used to prepare the pharmaceutical composition for the treatment of infantile diarrhea, do not appear in the newspapers as yet.
3, summary of the invention
In order to meet clinical needs, enlarge medicine variety, the invention provides a kind of infantile diarrhea that is mainly used in, be particularly useful for pharmaceutical composition of infantile autumn diarrhea and preparation method thereof.
Infantile autumn diarrhea belongs to the traditional Chinese medical science diseases caused by exogenous pathogenic factor category of having loose bowels, and is children's " the spleen tending to insufficiency usually ", the wet spleen that easily is stranded, make hypoactivity of spleen-YANG, fortuneization mistake department, damp heap soil or fertilizer over and around the roots stagnate in large intestine, clear QI being mixed up with turbid QI, lifting disloyal due to.Can adopt the principle treatment of " heat clearing and damp drying, relieving diarrhea with astringents " in view of the above.Herba Sarcandrae bitter in the mouth, suffering in the side, slightly warm in nature is returned lung, large intestine, Liver Channel, and major function is clearing away heat and cooling blood, dispelling wind and removing obstruction in the collateral, blood circulation promoting and dispersing pathogen accumulation; Pericarpium Granati sour in the mouth, puckery, warm in nature, return large intestine channel, relieving diarrhea with astringents, yang invigorating take off admittedly; The carbonized Rhizoma Zingiberis (processed) acrid in the mouth, slightly warm in nature, warming middle-JIAO to stop diarrhea, spleen invigorating removing food stagnancy.The three share, and the spleen sun must be shaken, damp and hot must removing, and the various symptoms of infantile diarrhea are improved or eliminate.Be used for the treatment of infantile diarrhea, effect is remarkable.
The consumption of making the crude drug of the contained composition and effectiveness of pharmaceutical composition of the present invention is that the inventor draws through groping in a large number to sum up, and it consists of: 5～25 parts of Herba Sarcandraes, 5～25 parts of Pericarpium Granatis, 2～20 parts of carbonized Rhizoma Zingiberis (processed).
The composition of making the crude drug of the contained composition and effectiveness of pharmaceutical composition of the present invention is preferably: 10～20 parts of Herba Sarcandraes, 10～20 parts of Pericarpium Granatis, 8～15 parts of carbonized Rhizoma Zingiberis (processed).
Make the contained composition and effectiveness of pharmaceutical composition of the present invention crude drug composition more preferably: 15 parts of Herba Sarcandraes, 15 parts of Pericarpium Granatis, 12 parts of carbonized Rhizoma Zingiberis (processed).
The crude drug of making the contained composition and effectiveness of pharmaceutical composition of the present invention is by weight as proportioning, when producing, can or reduce according to the corresponding proportion increase, as large-scale production can kilogram be unit, or be unit with the ton, small-scale production also can restrain and be unit, weight can increase or reduce, but the weight proportion between each composition is constant.The weight proportion of making the crude drug of the contained composition and effectiveness of pharmaceutical composition of the present invention obtains through science screening, and for especial patient, the ratio of can corresponding adjustment forming increases or reduce being no more than 100%.
As above weight portion can be that preparation is made by unit with the gram:
Herba Sarcandrae 450g Pericarpium Granati 450g carbonized Rhizoma Zingiberis (processed) 360g
Can be made into 1000 doses pharmaceutical preparation, can be made into 1000 as capsule, tablet can be made into 1000.
Aforementioned pharmaceutical compositions can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional formulation.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also these crude drug decocting together can be taken decocting liquid; In order to make the crude drug of making the contained composition and effectiveness of pharmaceutical composition of the present invention better bring into play drug effect, the invention provides following selection process, but these can not limit protection scope of the present invention.
The preparation method of aforementioned pharmaceutical compositions may further comprise the steps:
Take by weighing Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) of described parts by weight; The Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) that weigh up are decocted with water, merge the water extract, filter, filtrate is concentrated into finite concentration, add ethanol to finite concentration, stir, precipitate with ethanol is left standstill in cold preservation, filter, decompression filtrate recycling ethanol continues to be concentrated into thick paste to there not being the alcohol flavor, oven dry, pulverize, add adjuvant and make various preparations.
In the above-mentioned preparation method, preferred steps is:
Take by weighing Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) of described parts by weight; The Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) that weigh up are decocted with water the extraction secondary, add 6～8 times of amounts of water, extracted 2～3 hours, merge the water extract, filter, it is 1.10～1.20 that filtrate is concentrated into relative density, adding ethanol is 60～80% to containing the alcohol amount, stirs, and cold preservation was left standstill precipitate with ethanol 12～24 hours, filter, decompression filtrate recycling ethanol continues to be concentrated into thick paste to there not being the alcohol flavor, oven dry, pulverize, add adjuvant and make various preparations.
The step of above-mentioned preparation method is more preferably:
Take by weighing Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) of described parts by weight; The Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) that weigh up are decocted with water the extraction secondary, add 8 times of amounts of water for the first time, extracted 3 hours, for the second time add 6 times of amounts of water, extracted 2 hours, merge the water extract, filter, it is 1.15～1.18 that filtrate is concentrated into relative density, and adding ethanol is 70% to containing the alcohol amount, stir, cold preservation was left standstill precipitate with ethanol 24 hours, filtered, decompression filtrate recycling ethanol continues to be concentrated into thick paste to there not being the alcohol flavor, oven dry, pulverize, add adjuvant and make various preparations.
Pharmaceutical composition of the present invention has the poison of dispelling to hold back intestinal, warming spleen and stopping diarrha effect, is used for infantile autumn diarrhea.
Pharmaceutical composition of the present invention can add one or more pharmaceutically acceptable carriers and be mixed and made into clinically any or pharmaceutically acceptable dosage form, preferred oral preparation.When being applied to the patient who needs this treatment in the mode of oral administration, can be made into conventional solid preparation, as tablet, capsule, soft capsule, dispersible tablet, chewable tablet, oral cavity disintegration tablet, oral liquid, granule, drop pill, slow releasing tablet, slow releasing capsule, controlled release tablet, controlled release capsule etc.
When pharmaceutical composition of the present invention is made preparation, the conventional method production in the existing pharmaceutical field can be adopted, various pharmaceutically acceptable carriers can be added when needing.Described carrier comprises diluent, excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant of pharmaceutical field routine etc.
Pharmaceutical composition of the present invention is when making oral formulations, and selectable filler has: starch, Icing Sugar, calcium phosphate, calcium sulfate two water things, dextrin, microcrystalline Cellulose, lactose, pregelatinized Starch, mannitol etc.; Selectable binding agent has: sodium carboxymethyl cellulose, PVP-K30, hydroxypropyl cellulose, starch slurry, methylcellulose, ethyl cellulose, hypromellose, gelling starch etc.; Selectable disintegrating agent has: dried starch, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose etc.; Selectable lubricant has: magnesium stearate, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.
The advantage of pharmaceutical composition of the present invention is:
(1) provides a kind of new being used to prepare the pharmaceutical composition for the treatment of infantile autumn diarrhea, satisfied urgent clinical needs;
(2) show through pharmaceutical research, the pharmaceutical composition of making by Herba Sarcandrae, Pericarpium Granati and carbonized Rhizoma Zingiberis (processed) compatibility of the present invention, can significantly suppress the Oleum Ricini induced mice has loose bowels, significantly suppress the intestinal propulsion motion, significantly reduce rotavirus experimental rat faecal viruses and check number positive, clinical data shows that Drug therapy infantile autumn diarrhea effect of the present invention is remarkable.Show that Herba Sarcandrae, Pericarpium Granati and carbonized Rhizoma Zingiberis (processed) drug combination have synergism, drug effect is remarkable, and consequently those skilled in the art institute is beyond thought;
(3) preparation of pharmaceutical compositions technology of the present invention is simple, and mass discrepancy is little between the different batches medicine, and drug quality is uniform and stable.
Below example is further set forth the beneficial effect of pharmaceutical composition of the present invention by experiment, i.e. the pharmacological evaluation of the pharmaceutical composition of being made up of Herba Sarcandrae, Pericarpium Granati and carbonized Rhizoma Zingiberis (processed).
Experimental example 1 pharmaceutical composition of the present invention is to the have loose bowels influence of model of Oleum Ricini induced mice
Laboratory animal: ICR mice, 50.
Test sample: medicament composition granule agent of the present invention, prescription and method for making are seen embodiment 3;
Dioctahedral smectite, Bo Fu-beneficial general life (Tianjin) pharmaceutical Co. Ltd, 3g.
Experimental technique: get 50 of ICR mices, male and female half and half are divided into model control group at random, smecta group, the basic, normal, high dosage group of pharmaceutical composition of the present invention.Irritate stomach respectively by group and give relative medicine, model group gives the equal-volume normal saline, once a day, and continuous three days.After the last administration 40 minutes, every animal is irritated stomach and gives 0.2ml Oleum Ricini.The cell isolation cage that filter paper is arranged under then mice being put into, one of every lattice.Observation index: muck counting; The filter paper of shop one 10cm * 10cm area is made the muck counting under every cell.Reflect the degree of having loose bowels with muck grain number, changed filter paper once in preceding 1～6 hour, changed paper once in 7～24 hours, write down the accumulation muck sum of each animal in 24 hours, compare, organize a t check with SPSS software with model control group.The results are shown in Table 1.
Table 1 pharmaceutical composition of the present invention is to the anti-diarrhea effect of having loose bowels due to the Oleum Ricini (X ± SD)
Annotate: compare with model control group,
*P＜0.01.
Result: as seen by table 1, compare with model group, each dosage group of pharmaceutical composition of the present invention all can significantly suppress Oleum Ricini induced mice have loose bowels (p＜0.01), compare with smecta group, better effects if, show that the medicine composite for curing of being made by Herba Sarcandrae, Pericarpium Granati and carbonized Rhizoma Zingiberis (processed) of the present invention has loose bowels, effect is remarkable.
Experimental example 2 pharmaceutical compositions of the present invention are to the intestinal propulsion exercise testing
Laboratory animal: ICR mice, 50.
Test sample: medicament composition granule agent of the present invention, prescription and method for making are seen embodiment 3;
Imodium, Xian-Janssen Pharmaceutical Ltd., 2mg.
Experimental technique: get 50 of ICR mices, male and female half and half are divided into the normal control group at random, imodium group, the basic, normal, high dosage group of pharmaceutical composition of the present invention.Irritate stomach respectively by group and give relative medicine respectively, the normal control group gives the equal-volume normal saline, once a day, and continuous four days.Each organizes mice beginning fasting 24 hours in the 3rd day after administration.Tested the 4th day, and after the administration 1 hour, irritated stomach 5% Insta-Char 0.2ml/10g B.W..After 20 minutes, take off cervical vertebra and put to death animal, open the abdominal cavity, separate mesentery, on the clip to pylorus, down to the intestinal tube between the ileocecus, place on the flat low pallet, gently small intestinal is pulled into straight line, measure intestinal tube length as " small intestinal total length ", the distance from pylorus to the prepared Chinese ink forward position is as " prepared Chinese ink advances anxious distance at enteral ".Calculate prepared Chinese ink and advance percentage rate, organize a t check with SPSS software.The results are shown in Table 2.
The influence that table 2 pharmaceutical composition of the present invention moves to intestinal propulsion (X ± SD)
Annotate: compare with the normal control group,
*P＜0.05,
*P＜0.01.
Result: as seen by table 2, compare with the normal control group, pharmaceutical composition low dose group of the present invention has notable difference (p＜0.05) to the inhibitory action of intestinal propulsion motion, in the pharmaceutical composition of the present invention, there were significant differences (p＜0.01) for the inhibitory action that high dose group is moved to intestinal propulsion, compare with the imodium group, pharmaceutical composition low dose group weak effect of the present invention, in the pharmaceutical composition of the present invention, the high dose group effect is all better, show by Herba Sarcandrae, the pharmaceutical composition of the present invention that Pericarpium Granati and carbonized Rhizoma Zingiberis (processed) are made can reach the antidiarrheal purpose by suppressing the intestinal propulsion motion, and effect is remarkable.
Experimental example 3 pharmaceutical composition rotavirus experiments of the present invention
Laboratory animal: SD rat, 60.
Test sample: medicament composition granule agent of the present invention, prescription and method for making are seen embodiment 3;
Ribavirin tablet, Tianshikang Chinese Medicines Co., Ltd., Jiangxi, 20mg.
Experimental technique: 60 of SD rats, be divided into 6 groups at random, be respectively the normal control group, model control group, the ribavirin group, the basic, normal, high dosage group of pharmaceutical composition of the present invention, 10 every group, male and female half and half are all raised separately.During test, the rat of respectively organizing except that the normal control group is all irritated stomach with the rotavirus Cell sap, and each 2ml/ only (contains virus-4 * 10
4TCID50 virus).Every day 2 times is continuous 2 days.Played each group on the 3rd and irritate stomach with relative medicine respectively, dosage sees the following form, every day 1 time, continuous use 3 days.Normal control group, model control group are irritated stomach with normal saline, and method is together to the medicine group.
Observe rat every day and symptom whether occurs.From the 3rd day, gather rat feces every day and do virus inspection, taking internal organ was done the pathology inspection on 1.
The virus checking number positive relatively adopts the definite probability computing method of four fold table.
Rotavirus check result in the table 3 rat feces
Annotate:
#P＜0.05,
##Compare with the normal control group p＜0.01; Compare with model control group,
*P＜0.05,
*P＜0.01.
Result: learn that by table 3 during the beginning medication (the 3rd day), model control group and normal control group relatively have significant difference (p＜0.05); Compare with model control group, each administration group rat faecal viruses is checked number positive there was no significant difference.But rose in the 4th day, medication respectively group more all has explicitly or significant difference (p＜0.05, p＜0.01) with model control group, compares zero difference between investigational agent and positive group.
The internal organs pathologic finding shows that model control group rat large intestine mucous hyperemia is dispersed in lymphocytic infiltration, and the part rat has the special mess mucosal necrosis, comes off.Each dosage group mucous membrane of small intestine of pharmaceutical composition of the present invention is not seen obvious pathological change.All the other internal organs there is no pathological change.The result shows that pharmaceutical composition of the present invention has better protect effect and tangible anti-rotavirus effect to the laboratory animal of rotavirus infection.
The clinical prerun data of experimental example 4 pharmaceutical compositions of the present invention
Physical data: infantile autumn diarrhea patient 30 examples, all cases are all from outpatient service, male 18 examples, women 12 examples; Age is between 0～14 years old.All patients make a definite diagnosis by following standard.
The tcm diagnosis standard: (1) times of defecation increases, and is faint yellow every day 3～5 times or more, and as egg soup sample, or color is brown and smelly, and a small amount of mucus can be arranged.Or with feel sick, vomiting, stomachache, heating, disease such as thirsty.(2) excess in feeding is arranged, unhygienic diet or experience the medical history of damp.(3) stool is water sample or egg is flower-shaped about 20 times every day for severe diarrhoea, vomiting frequently, oliguria, fervescence, excessive thirst god withers, skin is shrivelled, sunken fontanel, the order nest sink, crying without tears, the lip cherry is red, breathes profoundly, and diseases such as abdominal distention also can be arranged.Possess above-mentioned (1) or (3) item, can make a definite diagnosis in conjunction with (2) item.
Therapeutic Method: medicament composition granule agent of the present invention is oral, each 3.5g, and every day 3 times, eliminating cold for resuscitation water is taken after mixing with liquid.5 days is 1 course of treatment.Carry out efficacy evaluation after finishing the course of treatment.
Criterion of therapeutical effect
Cure: times of defecation, character are recovered normally fully in 1 course of treatment, and unusual physical and chemical index recovers normal.Produce effects: in 1 course of treatment times of defecation obviously be reduced to 1/3 before the treatment or below, character takes a turn for the better, unusual physical and chemical index obviously improves.Effectively: in 1 course of treatment times of defecation reduce to 1/2 before the treatment or below, character takes a turn for the better, unusual physical and chemical index has improvement.Invalid: as not meet above standard person.
Therapeutic outcome: the present invention cures 15 examples, produce effects 10 examples, effective 3 examples, invalid 2 examples, total effective rate 93.3%.
Show that medicine composite for curing infantile autumn diarrhea of the present invention has good curative effect.
4, the specific embodiment
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following embodiment.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1: the preparation of pharmaceutical composition tablet of the present invention
Herba Sarcandrae 450g Pericarpium Granati 450g carbonized Rhizoma Zingiberis (processed) 360g
Take by weighing Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) of described parts by weight; The Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) that weigh up are decocted with water the extraction secondary, add 8 times of amounts of water for the first time, extracted 3 hours, add 6 times of amounts of water for the second time, extracted 2 hours, and merged the water extract, filter, it is 1.15～1.18 that filtrate is concentrated into relative density, and adding ethanol is 70% to containing the alcohol amount, stirs, cold preservation was left standstill precipitate with ethanol 24 hours, filtered, and decompression filtrate recycling ethanol is to there not being the alcohol flavor, continue to be concentrated into thick paste, oven dry is pulverized, add adjuvant and make granule, drying, compacting is in flakes.
Embodiment 2: the preparation of medicament composition capsule agent of the present invention
Herba Sarcandrae 400g Pericarpium Granati 400g carbonized Rhizoma Zingiberis (processed) 320g
Take by weighing Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) of described parts by weight; The Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) that weigh up are decocted with water the extraction secondary, add 8 times of amounts of water for the first time, extracted 3 hours, for the second time add 6 times of amounts of water, extracted 2 hours, merge the water extract, filter, it is 1.15～1.18 that filtrate is concentrated into relative density, and adding ethanol is 70% to containing the alcohol amount, stir, cold preservation was left standstill precipitate with ethanol 24 hours, filtered, decompression filtrate recycling ethanol continues to be concentrated into thick paste to there not being the alcohol flavor, oven dry, pulverize the snap fit capsule of packing into.
Embodiment 3: the preparation of medicament composition granule agent of the present invention
Herba Sarcandrae 450g Pericarpium Granati 450g carbonized Rhizoma Zingiberis (processed) 360g
Take by weighing Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) of described parts by weight; The Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) that weigh up are decocted with water the extraction secondary, add 8 times of amounts of water for the first time, extracted 3 hours, for the second time add 6 times of amounts of water, extracted 2 hours, merge the water extract, filter, it is 1.15～1.18 that filtrate is concentrated into relative density, and adding ethanol is 70% to containing the alcohol amount, stir, cold preservation was left standstill precipitate with ethanol 24 hours, filtered, decompression filtrate recycling ethanol continues to be concentrated into thick paste to there not being the alcohol flavor, oven dry, pulverize, adding Icing Sugar, binding agent are made granule.
Embodiment 4: the preparation of medicinal composition soft capsule of the present invention
Herba Sarcandrae 450g Pericarpium Granati 450g carbonized Rhizoma Zingiberis (processed) 360g
Take by weighing Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) of described parts by weight; The Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) that weigh up are decocted with water the extraction secondary, add 8 times of amounts of water for the first time, extracted 3 hours, add for the second time 6 times of amounts of water, extracted 2 hours, and merged the water extract, filter, it is 1.15～1.18 that filtrate is concentrated into relative density, adding ethanol is 70% to containing the alcohol amount, stirs, and cold preservation was left standstill precipitate with ethanol 24 hours, filter, decompression filtrate recycling ethanol continues to be concentrated into thick paste to there not being the alcohol flavor, oven dry, pulverize, with soybean oil and soybean phospholipid, Cera Flava heating and melting, mixing is put cold, add medicated powder, be pressed into soft capsule.
Embodiment 5: the preparation of medicament composition dropping pills of the present invention
Herba Sarcandrae 400g Pericarpium Granati 400g carbonized Rhizoma Zingiberis (processed) 320g
Take by weighing Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) of described parts by weight; With the Herba Sarcandrae that weighs up, Pericarpium Granati and carbonized Rhizoma Zingiberis (processed) decoct with water the extraction secondary, add 8 times of amounts of water for the first time, extract 3 hours, add for the second time 6 times of amounts of water, extracted 2 hours, and merged the water extract, filter, it is 1.15～1.18 that filtrate is concentrated into relative density, adding ethanol is 70% to containing the alcohol amount, stirs, and cold preservation was left standstill precipitate with ethanol 24 hours, filter, decompression filtrate recycling ethanol continues to be concentrated into thick paste to there not being the alcohol flavor, oven dry, pulverize, with polyethylene glycol 6000 heating and melting in water-bath, treat to add medicated powder after whole fusions, stirring and dissolving, 60 mesh sieves filter, and keep 60 ℃ to splash in the liquid paraffin that is chilled to below 10 ℃ and make ball.
Claims (7)
1. a pharmaceutical composition that is used for infantile diarrhea is characterized in that, the composition parts by weight of making the crude drug of the contained composition and effectiveness of this pharmaceutical composition are: 5～25 parts of Herba Sarcandraes, 5～25 parts of Pericarpium Granatis, 2～20 parts of carbonized Rhizoma Zingiberis (processed).
2. pharmaceutical composition according to claim 1 is characterized in that, the parts by weight of making the crude drug of the contained composition and effectiveness of this pharmaceutical composition are: 10～20 parts of Herba Sarcandraes, 10～20 parts of Pericarpium Granatis, 8～15 parts of carbonized Rhizoma Zingiberis (processed).
3. pharmaceutical composition according to claim 2 is characterized in that, the parts by weight of making the crude drug of the contained composition and effectiveness of this pharmaceutical composition are: 15 parts of Herba Sarcandraes, 15 parts of Pericarpium Granatis, 12 parts of carbonized Rhizoma Zingiberis (processed).
4. according to each described pharmaceutical composition of claim 1～3, it is characterized in that this pharmaceutical composition and mixing acceptable accessories are made arbitrary preparation.
5. pharmaceutical composition according to claim 4 is characterized in that this pharmaceutical composition and mixing acceptable accessories are made oral formulations.
6. according to each described preparation of drug combination method of claim 1～3, it is characterized in that:
Take by weighing Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) of described parts by weight, Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) that weighs up decocted with water the extraction secondary, add 6～8 times of amounts of water, extracted 2～3 hours, and merged the water extract, filter, it is 1.10～1.20 that filtrate is concentrated into relative density, and adding ethanol is 60～80% to containing the alcohol amount, stirs, cold preservation was left standstill precipitate with ethanol 12～24 hours, filtered, and decompression filtrate recycling ethanol is to there not being the alcohol flavor, continue to be concentrated into thick paste, oven dry is pulverized, and adds adjuvant and makes various preparations.
7. preparation of drug combination method according to claim 6 is characterized in that:
Take by weighing Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) of described parts by weight, the Herba Sarcandrae, Pericarpium Granati and the carbonized Rhizoma Zingiberis (processed) that weigh up are decocted with water the extraction secondary, add for the first time 8 times of amounts of water, extracted 3 hours, and added 6 times of amounts of water for the second time, extracted 2 hours, merge the water extract, filter, it is 1.15～1.18 that filtrate is concentrated into relative density, and adding ethanol is 70% to containing the alcohol amount, stir, cold preservation was left standstill precipitate with ethanol 24 hours, filtered, and decompression filtrate recycling ethanol is to there not being the alcohol flavor, continue to be concentrated into thick paste, oven dry is pulverized, and adds adjuvant and makes various preparations.
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| CNB2006100684020A CN100563706C (en) | 2006-08-18 | 2006-08-18 | A kind of pharmaceutical composition that is used for infantile diarrhea |
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| CNB2006100684020A CN100563706C (en) | 2006-08-18 | 2006-08-18 | A kind of pharmaceutical composition that is used for infantile diarrhea |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106109828A (en) * | 2016-08-01 | 2016-11-16 | 朱玉水 | A kind of oral preparation of Chinese traditional medicinal treating infant, infantile diarrhea and preparation method thereof |
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| CN102697850B (en) * | 2012-05-08 | 2014-12-24 | 广州市和生堂动物药业有限公司 | Traditional Chinese medicine composition for preventing and treating pig diarrhea |
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Non-Patent Citations (6)
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| 中药"肉蔻石榴汤"对婴幼儿秋季腹泻疗效观察. 阳照军，郭华.赣南医学院学报，第26卷第3期. 2006 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109828A (en) * | 2016-08-01 | 2016-11-16 | 朱玉水 | A kind of oral preparation of Chinese traditional medicinal treating infant, infantile diarrhea and preparation method thereof |
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