CN103520405B - A kind of have that heat clearing away is nourshing Yin and drynsessmoistening prescription, the pure Traditional Chinese medicine health-preserving preparation of benefiting QI and nourishing blood, function of relaxing bowel - Google Patents
A kind of have that heat clearing away is nourshing Yin and drynsessmoistening prescription, the pure Traditional Chinese medicine health-preserving preparation of benefiting QI and nourishing blood, function of relaxing bowel Download PDFInfo
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Abstract
The present invention relates to and a kind ofly have that heat clearing away is nourshing Yin and drynsessmoistening prescription, the pure Chinese medicine composition of benefiting QI and nourishing blood, function of relaxing bowel, said composition is made up of the crude drug of following weight: Aloe vulgaris lyophilized powder 40-80g, Radix Angelicae Sinensis extract 15-35g, Radix Panacis Quinquefolii extract 5-25g.Inventor bases oneself upon the rule for the treatment of of Chinese medical theory by benefiting QI and nourishing blood, treatment for clearing heat and moistening dryness by Sheng constipation, and by the raw material of three taste integration of edible and medicinal herbs, rigorous compatibility, specimen is same to be executed, heat clearing away, nourshing Yin and drynsessmoistening prescription, benefiting QI and nourishing blood, the effect of the relieving constipation that really secures good health.Prove that there is the health care of loosening bowel to relieve constipation through human experiment and animal function test.Meanwhile, said composition is sayed less for spiritlessness and weakness, shallow complexion, asthenia, insomnia forgetfulness, skin aging etc. have remarkable effect.
Description
Technical field
The present invention relates to a kind of compositions, have that heat clearing away is nourshing Yin and drynsessmoistening prescription, the pure Traditional Chinese medicine health-preserving preparation of benefiting QI and nourishing blood, function of relaxing bowel.
Background technology
Constipation is a symptom of common digestive system.Functional constipation is many because of caused by irrational diet and bowl evacuation habit; Minority is caused by organic disease.It is reported, U.S.'s statistics is 14.7% of people group's sickness rate, and have 4,000,000 people to suffer from constipation every year, 200-300 ten thousand people need take cathartic defecation assisting, has 920,000 people to suffer from constipation in inpatient, wherein 1% dies from constipation or constipation relevant disease.The multiple complications produced due to constipation, has had a strong impact on the quality of life of patient, has day by day paid attention to clinically to its diagnosis and treatment.
The objectify degree of modern medicine to the concept of constipation, classification, medicament categories and operative treatment is becoming better and approaching perfection day by day, and has promoted the reasonable cognition of constipation diagnosis and treatment.The Western medicine of the treatment constipation of applying clinically at present has: osmotic laxative, irritant laxative, emollient laxative, permeability caccagogue, dynamics-promoting medicine and 5-HT4 receptor stimulating agent etc.Osmotic laxative is also referred to as Epsom salts, because it is not absorbed by intestinal wall and water-soluble, therefore large quantity of moisture can be absorbed in intestinal, the capacity of stool is increased, play catharsis effect, the main representative medicine of such cathartic is magnesium sulfate, but because it can not make colon tension force increase, so should not be used for the slow patient of those intestinal movements; Irritant laxative effect is fast, effect is strong, the product of medicine or its metabolism can produce stimulation to intestinal wall, and enterokinesia is increased, and such medicine mainly contains: Oleum Ricini, Radix Et Rhizoma Rhei, Folium Sennae etc., but, this type of medicine because stimulate intestinal mucosa and intestinal wall plexus nervorum, and may cause large intestine myasthenia, forms drug dependence, thus be mainly used in stool incarceration and need rapid relieving constipation person, unsuitable prolonged application; Emollient laxative is also known as stool softener, and the major function of this type of medicine is lubrication intestinal wall, softening stool, makes to be convenient to greatly discharge, and as liquid paraffin etc., the main shortcoming of this kind of medicine is that mouthfeel is poor, and act on weak, prolonged application can cause fat soluble vitamin absorption bad; Permeability caccagogue, as lactulose, it is not absorbed by the body, work at colon by discharging organic acid after bacterial decomposition, especially old people, pregnant and lying-in women, child and postoperative constipation person is suitable for, but diabetic is cautious use of, the major defect of this type of medicine produces gas at bacterial action bottom fermentation, causes the senses of discomfort such as abdominal distention; Intestinal motive force medicine plays a role by strengthening myenteron tension force, but normal needs and other medicine conbined usage, 5-HT4 receptor stimulating agent, there are tegaserod, Polyethylene Glycol etc., the irritable bowel syndrome of tegaserod to constipation type has certain curative effect, is suitable for especially and uses osmotic laxative treatments and the still invalid patient of intestinal cellulose.Polyethylene Glycol is not because it is by intestinal absorption, also can not decompose in intestinal and produce acid, can be used for the constipation caused by many reasons of adult, but this medicine should not be used for struvite organic bowel diseases and not yet diagnosed stomachache patient, when taking this medicine preferably and other drug interval 2 hours.
The traditional Chinese medical science is thought, constipation is mainly caused by dryness-heat stagnating in the interior, depression and stagnation of QI, deficiency of body fluid and spleen-kidney vacuity cold.Treatment by Chinese herbs constipation has self characteristic and advantage, but at present in actual clinical, most of doctor still rest on use the irritant purgative such as Radix Et Rhizoma Rhei, Folium Sennae iatrogenic injury treatment on, lag behind the development of modern Chinese medicine completely.Therefore inquire into development to the harmless Chinese medicine composition of intestinal, and to deepen the reasonable cognition of modern Chinese medicine to intestinal tract disease diagnosis and treatment such as constipation with this be a very urgent task.
Aloe, for liliaceous plant Aloe vulgaris AloebarbadensisMiller, Aloe ferox Miller AloeferoxMiller or other belong to the dry product of concentrated juice of kindred plant leaf together.Hardship, cold.Return liver, stomach, large intestine channel.Removing heat from the liver, relieving constipation.For constipation, infantile malnutrition, infantile convulsion; External treatment exudative dermatitis.
Radix Angelicae Sinensis is the dry root of umbelliferae angelica Angelicasinensis (Oliv.) Diels.Autumn end excavates, and removing fibrous root and silt, after moisture slightly evaporates, be bundled into wisp, upper canopy, with pyrotechnics slowly smoke-dried beancurd.Sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Radix Panacis Quinquefolii is the dry root of Araliaceae Radix Panacis Quinquefolii PanaxquinquefoliumL..Be all cultivation product, autumn excavates, and cleans, dries or cold drying.Sweet, micro-hardship, cool.GUIXIN, lung, kidney channel.Boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Lose for deficiency of vital energy the moon, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired of tired, quenches one's thirst, dryness of the mouth and throat.
Summary of the invention
For reaching above object, one is provided to have heat clearing away nourshing Yin and drynsessmoistening prescription, benefiting QI and nourishing blood, function of relaxing bowel, and greatly reduce the Chinese medicine composition that intestinal stimulates and physiological is damaged, we according to motherland's medical science to the understanding of the intestinal tract diseases such as constipation, base oneself upon Chinese medicine and pass through benefiting QI and nourishing blood, the rule for the treatment of of treatment for clearing heat and moistening dryness by Sheng constipation, with reference to modern pharmacological research achievement and former various proved recipes, grain is gone to get essence, by the raw material of three taste integration of edible and medicinal herbs, rigorous compatibility, be prepared into a kind of Chinese medicine composition of loosening bowel to relieve constipation, simultaneously, said composition is for spiritlessness and weakness, shallow complexion, asthenia is sayed less, insomnia forgetfulness, skin aginges etc. have remarkable effect.
This Chinese medicine composition is made up of the crude drug of following weight: Aloe vulgaris full leaf lyophilized powder 40-80g, Radix Angelicae Sinensis extract 15-35g, Radix Panacis Quinquefolii extract 5-25g.
Preferred: Aloe vulgaris lyophilized powder 50-70g, Radix Angelicae Sinensis extract 20-30g, Radix Panacis Quinquefolii extract 10-20g.
Further preferably: Aloe vulgaris lyophilized powder 55-65g, Radix Angelicae Sinensis extract 22-28g, Radix Panacis Quinquefolii extract 12-18g.
Most preferably: Aloe vulgaris lyophilized powder 60g, Radix Angelicae Sinensis extract 25g, Radix Panacis Quinquefolii extract 15g.
Wherein, Radix Angelicae Sinensis extract, Radix Panacis Quinquefolii extract processing technology are: water boiling and extraction 1-3 time, each 1-3 hour, and amount of water is 8-10 times amount, and medicinal liquid filtration, purification, concentrating under reduced pressure, drying under reduced pressure, pulverizing, to obtain final product;
The preparation method of Chinese medicine composition of the present invention comprises the following steps:
(1) take according to crude drug part by weight, sieve 80 orders, for subsequent use;
(2) Radix Angelicae Sinensis extract, Radix Panacis Quinquefolii extract processing technology are water boiling and extraction 1-3 time, each 1-3 hour, and amount of water is 8-10 times amount, and medicinal liquid filtration, purification, concentrating under reduced pressure, drying under reduced pressure, pulverizing, to obtain final product;
(3), after Aloe vulgaris defibrination, vacuum lyophilization obtains lyophilized powder;
(4) lyophilized powder of the powder of step (2) gained and step (3) gained is merged, be prepared into pharmaceutically acceptable preparation.
Those skilled in the art prepare knowledge according to common preparation, can be out of shape arbitrarily on this basis, and such as, the preparation method of soft capsule of the present invention is:
Get crude drug: Aloe vulgaris lyophilized powder, Radix Angelicae Sinensis extract, Radix Panacis Quinquefolii extract;
Wherein, Radix Angelicae Sinensis extract processing technology: water boiling and extraction 2 times, each 2 hours, amount of water was 8 times amount, and medicinal liquid filtration, purification, concentrating under reduced pressure, drying under reduced pressure, pulverizing, to obtain final product;
Radix Panacis Quinquefolii extract processing technology: water boiling and extraction 3 times, each 1.5 hours, amount of water was 10 times amount, and medicinal liquid filtration, purification, concentrating under reduced pressure, drying under reduced pressure, pulverizing, to obtain final product;
After Aloe vulgaris defibrination, vacuum lyophilization obtains Aloe vulgaris lyophilized powder:
(1) take according to crude drug part by weight, cross 80 mesh sieves respectively, for subsequent use;
(2) feed liquid preparation, get appropriate soybean oil and Cera Flava is put in material-compound tank, heating makes the complete melting of Cera Flava and stirs, obtain oily wax liquid: add in material-compound tank by above-mentioned Aloe vulgaris lyophilized powder for subsequent use, Radix Angelicae Sinensis extract, Radix Panacis Quinquefolii extract, stir with oily wax liquid, cross colloid mill grinding, obtain feed liquid for subsequent use;
(3) glue preparation: by purified water and putting of glycerol glue tank, after being heated to 60-65 DEG C, adds gelatin and red ferric oxide glue and stirs; Stop heating after temperature rises to 80 DEG C, and filter, it is for subsequent use that plastic emitting obtains glue;
(4) pelleting: carried out being pressed into ball by machine in the glue prepared and feed liquid with soft capsule pellet press, regulates every loading amount to be 0.5g, to obtain final product.
In invention formulation, described Chinese medicine composition dosage form is soft or hard capsule, tablet, granule, powder or oral liquid, for enabling above-mentioned dosage form realize, can add the acceptable adjuvant of pharmacy when preparing these dosage forms, such as: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic etc., filler comprises: starch, pregelatinized Starch, maltodextrin, mannitol, microcrystalline Cellulose, Semen sojae atricolor wet goods, disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone etc., lubricant comprises: magnesium stearate, Pulvis Talci, silicon dioxide etc., suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, Cera Flava, agar, hydroxypropyl emthylcellulose etc., binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc., sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc., correctives comprises: sweeting agent and various essence, and antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters etc.
Detailed description of the invention
Embodiment 1
Get crude drug: Aloe vulgaris lyophilized powder 60g, Radix Angelicae Sinensis extract 25g, Radix Panacis Quinquefolii extract 15g.
(1) take according to crude drug part by weight, cross 80 mesh sieves;
(2) Radix Angelicae Sinensis extract, Radix Panacis Quinquefolii extract processing technology are water boiling and extraction 3 times, and each 3 hours, amount of water was 8 times amount, and medicinal liquid filtration, purification, concentrating under reduced pressure, drying under reduced pressure, pulverizing, to obtain final product;
(3), after Aloe vulgaris defibrination, vacuum lyophilization obtains lyophilized powder;
(4) lyophilized powder of the powder of step (2) gained and step (3) gained is merged, mix with appropriate amount of starch, fully mix after sieving, be distributed in capsule and get final product, every 0.2g or every 0.4g.
Embodiment 2
Get crude drug: Aloe vulgaris lyophilized powder 5g, Radix Angelicae Sinensis extract 28g, Radix Panacis Quinquefolii extract 12g.
(1) take according to crude drug part by weight, cross 80 mesh sieves;
(2) Radix Angelicae Sinensis extract, Radix Panacis Quinquefolii extract processing technology water boiling and extraction 1-3 time, each 1-3 hour, amount of water is 8-10 times amount, and medicinal liquid filtration, purification, concentrating under reduced pressure, drying under reduced pressure, pulverizing, to obtain final product;
(3), after Aloe vulgaris defibrination, vacuum lyophilization obtains lyophilized powder;
(4) merged by the lyophilized powder of the powder of step (2) gained and step (3) gained, use appropriate distilled water diluting, filter, diluent is 20% containing crude drug amount, adds simple syrup, potassium sorbate, obtained oral liquid.
Embodiment 3
Get crude drug: Aloe vulgaris lyophilized powder 70g, Radix Angelicae Sinensis extract 20g, Radix Panacis Quinquefolii extract 20g.
(1) take according to crude drug part by weight, cross 80 mesh sieves;
(2) Radix Angelicae Sinensis extract, Radix Panacis Quinquefolii extract processing technology water boiling and extraction 1-3 time, each 1-3 hour, amount of water is 8-10 times amount, and medicinal liquid filtration, purification, concentrating under reduced pressure, drying under reduced pressure, pulverizing, to obtain final product;
(3), after Aloe vulgaris defibrination, vacuum lyophilization obtains lyophilized powder;
(4) lyophilized powder of the powder of step (2) gained and step (3) gained is merged, use appropriate distilled water diluting, with appropriate amount of starch, Pulvis Talci and magnesium stearate, mixing, direct compression and get final product after sieving.Every sheet 0.4g.
Embodiment 4
Get crude drug: Aloe vulgaris lyophilized powder 80g, Radix Angelicae Sinensis extract 25g, Radix Panacis Quinquefolii extract 10g.
(1) take according to crude drug part by weight, cross 80 mesh sieves;
(2) Radix Angelicae Sinensis extract, Radix Panacis Quinquefolii extract processing technology water boiling and extraction 1-3 time, each 1-3 hour, amount of water is 8-10 times amount, and medicinal liquid filtration, purification, concentrating under reduced pressure, drying under reduced pressure, pulverizing, to obtain final product;
(3), after Aloe vulgaris defibrination, vacuum lyophilization obtains lyophilized powder;
(4) lyophilized powder of the powder of step (2) gained and step (3) gained is merged, add 30mL anhydrous alcohol for medical use, stir, make soft material.Added in the oscillating granulator that 14 eye mesh screens are housed by soft material, make wet granular, 50 DEG C of oven dry in heated-air circulation oven, granulate, adds magnesium stearate 5g, mixing, uses composite film packaging, inspection, obtains granular pattern electuary.
Embodiment 5
Get crude drug: Aloe vulgaris lyophilized powder 60g, Radix Angelicae Sinensis extract 25g, Radix Panacis Quinquefolii extract 15g.
Wherein, Radix Angelicae Sinensis extract processing technology: water boiling and extraction 2 times, each 2 hours, amount of water 8 times amount, medicinal liquid filtration, purification, concentrating under reduced pressure, drying under reduced pressure, pulverizing, to obtain final product; Radix Panacis Quinquefolii extract processing technology: water boiling and extraction 3 times, each 1.5 hours, amount of water 10 times amount, medicinal liquid filtration, purification, concentrating under reduced pressure, drying under reduced pressure, pulverizing, to obtain final product:
After Aloe vulgaris defibrination, vacuum lyophilization obtains the full leaf lyophilized powder of Aloe vulgaris;
(1) take according to crude drug part by weight, cross 80 mesh sieves respectively, for subsequent use;
(2) feed liquid preparation, gets appropriate soybean oil and Cera Flava is put in material-compound tank, and heating makes the complete melting of Cera Flava and stirs, and obtains oily wax liquid; Complete for above-mentioned Aloe vulgaris for subsequent use leaf lyophilized powder, Radix Angelicae Sinensis extract, Radix Panacis Quinquefolii extract are added in material-compound tank, stirs with oily wax liquid, cross colloid mill grinding, obtain feed liquid for subsequent use;
(3) glue preparation: by purified water and putting of glycerol glue tank, after being heated to 60-65 DEG C, adds gelatin and red ferric oxide glue and stirs; Stop heating after temperature rises to 80 DEG C, and filter, it is for subsequent use that plastic emitting obtains glue;
(4) pelleting: carried out being pressed into ball by machine in the glue prepared and feed liquid with soft capsule pellet press, regulates every loading amount to be 0.5g, to obtain final product.
Embodiment 6 clinical experiment is reported
1. sample and experimental subject
Test-meal group: soft capsule prepared by embodiment 5,0.5 gram every, every day 2 times, each 2.
Matched group: with Aloe vulgaris lyophilized powder 100g for raw material, the soft capsule prepared according to the same method of embodiment 5,0.5 gram every, every day 2 times, each 2.
Clinical experiment object: select connect voluntarily subject constipation patient 100 example, man 50 example, female 50 example, age 28-56 year, average 45 years old.Patient is all habitual constipation by clinical diagnosis, before experiment, it is divided into 2 groups at random, often organizes 50 people.
2. Appreciation gist
" health food inspection and assessment technical specification " (version in 2003)
3. on the impact of defecation frequency
Defecation frequency compares (secondary/week) before table 1 test-meal and during test-meal
* self compares P<0.01, compares P<0.01 between ## group
Before test-meal, the defecation frequency of test-meal group and matched group does not have significant difference, has comparability.Second week after test-meal, test-meal group defecation frequency increases than before test-meal, and difference has extremely significantly meaning (P<0.01) compared with before test-meal; And difference has extremely significantly meaning (P<0.01) compared with the defecation frequency of matched group, illustrates and takes the defecation frequency that soft capsule of the present invention can increase constipation person.
4. on the impact of experimenter's defecation condition
Integral of defecation condition compares before table 2 test-meal and during test-meal
* self compares P<0.01, compares P<0.01 between ## group
Last integral of defecation condition before two groups of experimenter's test-meals does not have significant difference, has comparability.After test-meal, the last integral of defecation condition of test-meal group reduces, difference has extremely significantly meaning (P<0.01) compared with before test-meal, and has extremely significantly meaning (P<0.01) with matched group comparing difference.Illustrate and take the defecation condition that soft capsule of the present invention can improve constipation person.
5. on the impact of experimenter's feces character
Feces character integral contrast before table 3 test-meal and during test-meal
* self compares P<0.01, compares P<0.01 between ## group, compares P<0.05 between # group
Last feces character integration before two groups of experimenter's test-meals does not have significant difference, has comparability.After test-meal, test-meal group last feces character integration reduces, and has extremely significantly reduce (P<0.01) with comparing difference before test-meal; And compare with matched group and have pole significant difference (P<0.01).Illustrate and take the feces character that soft capsule of the present invention can improve constipation person.
6. conclusion
Result shows: after test-meal group takes soft capsule of the present invention, self compare defecation frequency before test-meal and after test-meal and on average increase 1.42+1.07 time/week (P<0.01), last integral of defecation condition decreased average 0.92 ± 0.85 (P<0.01), last feces character integral mean reduces 0.64+0.80 (P<0.01); Compare defecation frequency after test-meal between test-meal group with matched group group to increase (P<0.01), last integral of defecation condition and feces character integration reduce (P<0.01).During test-meal, the dietary habit of two groups of experimenters, food and dietary fiber intake thereof do not have difference, without significant change before and after the safety indexes test-meal such as blood routine, blood parameters, routine urinalysis, blood pressure of two groups, normally, not there is untoward reaction in experimenter simultaneously for electrocardiogram, Chest X-rays, Abdominal B type ultrasonography.Prove that soft capsule of the present invention has bowel relaxing functions to human body, and without obvious damage effect.There is the significant difference on statistical significance simultaneously compared with matched group, after proving crude drug of the present invention combination, create synergism, there is unforeseeable technique effect.
Embodiment 7 Report on Animal
1. given the test agent and experimental subject
Solvent control group: normal saline, normal mouse.
Aloe vulgaris lyophilized powder group: be dissolved in normal saline is 20% (w/w) containing crude drug amount, mice with constipation, 1.00g/kg.
Radix Angelicae Sinensis extract group: the method process Radix Angelicae Sinensis extract adopting embodiment 5, being dissolved in normal saline, is 20% (w/w) containing crude drug amount, mice with constipation, 1.00g/kg.
Radix Panacis Quinquefolii extract group: the method process Radix Panacis Quinquefolii extract adopting embodiment 5, being dissolved in normal saline, is 20% (w/w) containing crude drug amount, mice with constipation, 1.00g/kg.
Positive controls: adopt powder prepared by CN102362970A embodiment 1 method, being dissolved in normal saline, is 20% (w/w) containing crude drug amount, mice with constipation, 1.00g/kg.
Invention group: be divided into basic, normal, high dosage three groups, is equivalent to crude drug amount and is respectively 0.17g/kg; 0.33g/kg and 1.00g/kg, soft capsule prepared by embodiment 5 gets contents melting in normal saline, is 20% (w/w) containing crude drug amount, mice with constipation.
Model control group: normal saline, mice with constipation.
Above matched group is except invention group, and dosage is 1.00g/kg.
Zoopery object: normal mouse: healthy adult Kunming kind male white mouse, body weight 18-22g.
Mice with constipation: carry out modeling to healthy adult Kunming kind male white mouse according to literature method, obtains mice with constipation.
2. Appreciation gist and experimental technique
Appreciation gist: " health food inspection and assessment technical specification " (version in 2003)
Experimental technique: mice is designed to invention group (being divided into high, medium and low dosage three groups), solvent control group, model control group, positive controls, Aloe vulgaris lyophilized powder group, Radix Angelicae Sinensis extract group, Radix Panacis Quinquefolii extract group totally 9 groups, often organizes 24.Oral administration gastric infusion, continuous 7 days, respectively organized and first carried out the experiment of mice defecation with half mice, within the 9th day, carry out intestinal propulsion experiment with second half mice of residue on the 8th day every day.
3. on the impact of mouse small intestine ahead running
Fasting 24h before experiment, take burnt black ink as label, blank group gavage gives the burnt black ink solution of normal saline; Administration group is then with the burnt black ink solution preparation medicinal liquid of same concentration, after gavage after 30min, cervical dislocation process mice, take out the whole section small intestinal of stomach to blind portion, be laid on glass plate, measure pylorus to ileocecum total length as small intestinal total length, and pylorus to ink advances the distance in forward position as ink advance distance, calculate ink propelling rate.
Table 4 is on the impact of mouse small intestine ahead running
Note: each dosage group compares with to model control group
From table 4, per os gives the given the test agent 9 days of mice various dose, and model control group Intestinal propulsive rate is lower than solvent control group, and difference has extremely significantly meaning (P<0.01), represents that Constipation Model is successfully established.1.00g/kg dosage group Intestinal propulsive rate is higher than model control group, and difference has extremely significantly meaning (P<0.01), and under pointing out this experiment condition, given the test agent has potentiation to mouse small intestine ahead running.
In addition, compare positive controls and each single medicinal material group, of the present invention group also achieves better effect, especially 1.00g/kg dosage group, successful is better than matched group, and this also points out the combination through the rigorous screening of inventor and three taste crude drug of compatibility to create obvious synergism.
4. on the impact of mice defecation time and feces volume
Table 5 is on the impact of mice defecation time and feces volume
Note: each dosage group compares according to group with to model
From table 5, the first grain of model control group mice arranges melena time, melena grain number, melena weight and solvent control group comparing difference all extremely significantly meaning (P<0.01), represents that Constipation Model is successfully established.Per os gives the given the test agent 7 days of mice various dose, first grain row's melena time of 1.00g/kg dosage group mice is shorter than model control group, in 5 hours, mice row melena grain number, weight are higher than model control group, with model control group comparing difference significance (P<0.05).Under pointing out this experiment condition, given the test agent can shorten little mouse's head grain row's melena time, increase mice row's melena grain number and weight.
In addition, compare positive controls and each single medicinal material group, of the present invention group also achieves better effect, especially 1.00g/kg dosage group, successful is better than matched group, and this also points out the combination through the rigorous screening of inventor and three taste crude drug of compatibility to create obvious synergism.
Claims (8)
1. a Chinese medicine composition for loosening bowel to relieve constipation, is characterized in that, is made up of the crude drug of following weight: Aloe vulgaris lyophilized powder 50-70g, Radix Angelicae Sinensis extract 20-30g, Radix Panacis Quinquefolii extract 10-20g;
Wherein, Radix Angelicae Sinensis extract, Radix Panacis Quinquefolii extract processing technology water boiling and extraction 1-3 time, each 1-3 hour, amount of water 8-10 times amount, medicinal liquid filtration, purification, concentrating under reduced pressure, drying under reduced pressure, pulverizing, to obtain final product; After Aloe vulgaris defibrination, vacuum lyophilization obtains lyophilized powder.
2. Chinese medicine composition as claimed in claim 1, is characterized in that, be made up of the crude drug of following weight: Aloe vulgaris lyophilized powder 55-65g, Radix Angelicae Sinensis extract 22-28g, Radix Panacis Quinquefolii extract 12-18g.
3. Chinese medicine composition as claimed in claim 1, is characterized in that, be made up of the crude drug of following weight: Aloe vulgaris lyophilized powder 60g, Radix Angelicae Sinensis extract 25g, Radix Panacis Quinquefolii extract 15g.
4. the Chinese medicine composition as described in any one of claim 1-3, is characterized in that: described Chinese medicine composition dosage form is soft or hard capsule, tablet, granule, powder, pill or oral liquid.
5. the preparation method of the Chinese medicine composition as described in any one of claim 1-3, is characterized in that: comprise the following steps:
(1) take according to crude drug part by weight, cross 80 mesh sieves;
(2) Radix Angelicae Sinensis extract, Radix Panacis Quinquefolii extract processing technology water boiling and extraction 1-3 time, each 1-3 hour, amount of water 8-10 times amount, medicinal liquid filtration, purification, concentrating under reduced pressure, drying under reduced pressure, pulverizing, to obtain final product;
(3), after Aloe vulgaris defibrination, vacuum lyophilization obtains lyophilized powder;
(4) lyophilized powder of the powder of step (2) gained and step (3) gained is merged, be prepared into pharmaceutically acceptable preparation.
6. the preparation method of the Chinese medicine composition as described in any one of claim 1-3, is characterized in that: comprise the following steps:
Get crude drug: Aloe vulgaris lyophilized powder, Radix Angelicae Sinensis extract, Radix Panacis Quinquefolii extract;
Wherein, Radix Angelicae Sinensis extract processing technology: water boiling and extraction 2 times, each 2 hours, amount of water 8 times amount, medicinal liquid filtration, purification, concentrating under reduced pressure, drying under reduced pressure, pulverizing, to obtain final product;
Radix Panacis Quinquefolii extract processing technology: water boiling and extraction 3 times, each 1.5 hours, amount of water 10 times amount, medicinal liquid filtration, purification, concentrating under reduced pressure, drying under reduced pressure, pulverizing, to obtain final product;
After Aloe vulgaris defibrination, vacuum lyophilization obtains the full leaf lyophilized powder of Aloe vulgaris;
(1) take according to crude drug part by weight, cross 80 mesh sieves respectively, for subsequent use;
(2) feed liquid preparation, gets appropriate soybean oil and Cera Flava is put in material-compound tank, and heating makes the complete melting of Cera Flava and stirs, and obtains oily wax liquid; Above-mentioned Aloe vulgaris lyophilized powder for subsequent use, Radix Angelicae Sinensis extract, Radix Panacis Quinquefolii extract are added in material-compound tank, stirs with oily wax liquid, cross colloid mill grinding, obtain feed liquid for subsequent use;
(3) glue preparation: by purified water and putting of glycerol glue tank, after being heated to 60-65 DEG C, adds gelatin and red ferric oxide glue and stirs; Stop heating after temperature rises to 80 DEG C, and filter, it is for subsequent use that plastic emitting obtains glue;
(4) pelleting: carried out being pressed into ball by machine in the glue prepared and feed liquid with soft capsule pellet press, regulates every loading amount to be 0.5g, to obtain final product.
7. the Chinese medicine composition as described in any one of claim 1-3 is preparing the application in loosening bowel to relieve constipation medicine.
8. the application of the Chinese medicine composition as described in any one of claim 1-3 in preparation treatment constipation medicine.
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| CN104524050A (en) * | 2015-01-10 | 2015-04-22 | 黄家亨 | Compound cathartic agent and preparing method thereof |
| CN105341890A (en) * | 2015-11-17 | 2016-02-24 | 广东红珊瑚药业有限公司 | Health food possessing bowel-relaxing effect and preparation method thereof |
| CN107753514A (en) * | 2017-11-23 | 2018-03-06 | 铜陵市东方矿冶机械有限责任公司 | Liquid paraffin breast and preparation method thereof |
| CN116966238A (en) * | 2019-03-21 | 2023-10-31 | 清华德人西安幸福制药有限公司 | Traditional Chinese medicine composition for relaxing bowel, preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1104895A (en) * | 1993-11-18 | 1995-07-12 | 王英行 | Quick acting catharsis pill |
| CN103211215A (en) * | 2013-04-25 | 2013-07-24 | 福建永生活力生物工程有限公司 | Health food with function of relaxing bowels and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1104895A (en) * | 1993-11-18 | 1995-07-12 | 王英行 | Quick acting catharsis pill |
| CN103211215A (en) * | 2013-04-25 | 2013-07-24 | 福建永生活力生物工程有限公司 | Health food with function of relaxing bowels and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 芦荟通便功能的临床观察;曹文瑜等;《海峡预防医学杂志》;20051231;第11卷(第06期);参见第36页材料部分及第37页讨论部分第2-3段 * |
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