CN104056234A - Drug for dispelling alcohol effect and preparing method thereof - Google Patents
Drug for dispelling alcohol effect and preparing method thereof Download PDFInfo
- Publication number
- CN104056234A CN104056234A CN201410304905.8A CN201410304905A CN104056234A CN 104056234 A CN104056234 A CN 104056234A CN 201410304905 A CN201410304905 A CN 201410304905A CN 104056234 A CN104056234 A CN 104056234A
- Authority
- CN
- China
- Prior art keywords
- parts
- pericarpium citri
- citri reticulatae
- volatile oil
- effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a drug for dispelling the alcohol effect and a preparing method thereof. The drug is formed by preparing pericarpium citri reticulatae viride, radix aucklandiae, pericarpium citri reticulatae, ginseng, polyporus umbellatus, white poria cocos, medicated leaven, rhizoma alismatis, dry ginger, rhizoma atractylodis, white alpiniakatat sumadai hayata, flos puerariae, fructus amomi, turtle shells, curcuma zedoaria, rabdosia rubescens, humulus, radix ranunculi ternate, herba lysimachiae, hypericum japonicum and auxiliary materials. The drug has the effects of dispelling the alcohol damp, regulating qi and strengthening the spleen, has the exact curative effect on liquor accumulation, emesis, diarrhea, glomus blockage, headache and difficult urination, is remarkable in medicinal cure effect and has no toxic and side effect.
Description
Invention field:
The present invention relates to a kind of medicine relieving the effect of alcohol and preparation method thereof, belong to the field of medicine technology.
Technical background:
Many people can drink in a large number because of dinner party, and this makes health be subject to serious harm, but in order to work, in order to communicate, often have to drink.Drunk is acute alcoholism in fact, when ethanol enters after human body, can suppress the generation of vassopressin.When health lacks after this parahormone, kidney will be suppressed the absorption of moisture, moisture in body is a large amount of run off after, the electrolyte balance of body fluid will be damaged, and causes nausea, the ill symptoms such as dizzy and headache.Expert studies discovery, drinks and surpasses after 6 minutes, and brain cell just starts to be damaged.If excessive drinking for a long time, memory just there will be the phenomenon of decline.After excessive drinking, ethanol will acceleration bodies in calcareous a large amount of losses, be easy to occur osteoporosis symptom, or even fracture.So the drunk kidney to human body, liver, taste, brain, skeleton has serious impact.But people but often do not plead dinner party and continue to drink, so antialcoholic drug is rescued, arise at the historic moment.At present, for drunk, doctor trained in Western medicine does not temporarily have better way.The chemical composition energy and the alcohol molecule generation chemical reaction that on market, yet there is no a kind of finished medicines, relieving the effect of alcohol on the market can only be played the effect of respite mostly, cannot eliminate the infringement of ethanol to human liver and stomach organ, even have some antialcoholic drugs also can cause the damage of Liver and kidney.Someone thinks the healthy effect of benefit of relieving the effect of alcohol of having tea after drinking, and Chinese medical theory is thought like this: vinosity is pungent, enters lung, lung governing skin and hair, and the lung and the large intestine being interior-exteriorly related, drinks and should get the property that its yang invigorating is dispersed, and makes yang-energy increase, and lung qi is stronger, promotes qi and blood circulation.Tea flavour is bitter, belongs to cloudy, and main falling, can drive alcoholic strength in kidney if drink tea after drinking.Have tea after drinking and can bring damage to kidney.And the main water of kidney is aquatic wet, so form cold stagnant.Cold stagnant frequent micturition, sexual impotence, the testis of causing falls the diseases such as pain, constipation due to dry stool.These methods all can only temporarily be suppressed drunk or not effect, even also increase the weight of human body burden, make human lesion.Therefore, invent and a kind ofly can have the effect of relieving the effect of alcohol to be of value to again Chinese patent medicine health and that carry taking convenience to have important practical significance.
Summary of the invention:
Technical problem to be solved by this invention is to provide a kind of medicine relieving the effect of alcohol and preparation method thereof.It is wet that described medicine has the wine that minute disappears, the effect of regulating qi-flowing for strengthening spleen, and to the wine painful abdominal mass plug that amasss, vomits, has loose bowels, headache, dysuria etc. have definite curative effect.
For solving above technical problem, the present invention realizes by the following technical solutions:
A kind of medicine relieving the effect of alcohol, according to composition by weight, calculate, by Pericarpium Citri Reticulatae Viride 15-50 part, Radix Aucklandiae 30-60 part, Pericarpium Citri Reticulatae 100-150 part, Radix Ginseng 100-150 part, Polyporus 100-150 part, Poria 100-150 part, Massa Medicata Fermentata 150-200 part, Rhizoma Alismatis 150-200 part, dry Rhizoma Zingiberis Recens 150-200 part, Rhizoma Atractylodis Macrocephalae 150-200 part, Semen Vignae Cylindricae KOUREN 300-500 part, Flos puerariae lobatae 300-500 part, Fructus Amomi 300-500 part, Carapax Trionycis 400-600 part, Rhizoma Curcumae 100-200 part, Rabdosia rubescens 400-600 part, Herba humuli scandentis 400-600 part, Radix Ranunculi Ternati 400-600 part, Herba Lysimachiae 400-600 part, Herba Hyperici Japonici 400-600 part and adjuvant are prepared from.
Specifically, the aforementioned medicine relieving the effect of alcohol calculates according to composition by weight, by 27 parts, Pericarpium Citri Reticulatae Viride, 45 parts of the Radix Aucklandiae, 135 parts of Pericarpium Citri Reticulataes, 135 parts of Radix Ginsengs, 135 parts of Polyporus, 135 parts of Porias, 180 parts of Massa Medicata Fermentata, 180 parts of Rhizoma Alismatis, 180 parts, dry Rhizoma Zingiberis Recens, 180 parts of the Rhizoma Atractylodis Macrocephalaes, 450 parts of Semen Vignae Cylindricae KOUREN, 450 parts of Flos puerariae lobataes, 450 parts of Fructus Amomis, 500 parts of Carapax Trionycis, 150 parts of Rhizoma Curcumae, 500 parts of Rabdosia rubescens, 500 parts of Herba humuli scandentis, 500 parts of Radix Ranunculi Ternatis, 500 parts of Herba Lysimachiaes, 500 parts of Herba Hyperici Japonici and adjuvant, is prepared from.
The preparation method of the aforementioned medicine relieving the effect of alcohol is: proportionally take each medical material, combine, and process according to conventional preparation method with acceptable pharmaceutic adjuvant in medicine, make corresponding pharmaceutical preparation.
Specifically, the preparation method of the aforementioned medicine relieving the effect of alcohol, it is characterized in that: get Semen Vignae Cylindricae KOUREN, Fructus Amomi, dry Rhizoma Zingiberis Recens, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, it is 40 object granules that Rhizoma Curcumae is pulverized respectively, the water that adds 8 times of amounts, with extraction by steam distillation volatile oil 3 hours, collect volatile oil, in medicinal residues and side, remaining medical material merges, add 8 times of water gagings, extract 3 times, each 1 hour, filter, dregs pressing, merge 3 times extracting solution, standing over night, the remove impurity of supernatant high speed centrifugation, medicinal liquid is condensed into extractum, combine with acceptable pharmaceutic adjuvant in above-mentioned volatile oil and medicine, and process according to conventional preparation method, make corresponding pharmaceutical preparation.
Described pharmaceutical preparation is soft extract, hard capsule, ointment, tablet, granule, pill, oral liquid, syrup, powder, sublimed preparation, suspensoid, solution, injection, freeze-dried powder, bulk capacity injection, suppository, plaster, cream, spray or patch.
Specifically, described pharmaceutical preparation is soft extract, capsule, granule or oral liquid.
Described soft extract is prepared like this: get Semen Vignae Cylindricae KOUREN, Fructus Amomi, dry Rhizoma Zingiberis Recens, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Rhizoma Curcumae is pulverized is respectively 40 object granules, adds the water of 8 times of amounts, with extraction by steam distillation volatile oil 3 hours, collect volatile oil, in medicinal residues and side, remaining medical material merges, and adds 8 times of water gagings, extract 3 times, each 1 hour, filter dregs pressing, merge 3 times extracting solution, standing over night, the remove impurity of supernatant high speed centrifugation, the extractum that when medicinal liquid is concentrated into 60 ℃, relative density is 1.15-1.20; Separately get the Mel of the amount of making 10-50%, add in extractum, stir, with slow fire heating, receive cream, waiting to get a little can horizontal drawing filamentation, or while dripping on paper not water breakthrough mark, adds volatile oil, stirs evenly, and obtains.
Described capsule is prepared like this: get Semen Vignae Cylindricae KOUREN, Fructus Amomi, dry Rhizoma Zingiberis Recens, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, it is 40 object granules that Rhizoma Curcumae is pulverized respectively, the water that adds 8 times of amounts, with extraction by steam distillation volatile oil 3 hours, collect volatile oil, in medicinal residues and side, remaining medical material merges, add 8 times of water gagings, extract 3 times, each 1 hour, filter, dregs pressing, merge 3 times extracting solution, standing over night, the remove impurity of supernatant high speed centrifugation, the extractum that when medicinal liquid is concentrated into 60 ℃, relative density is 1.15-1.20, 70 ℃ of drying under reduced pressure become dry extract, pulverize, add above-mentioned volatile oil, the Icing Sugar of the amount of making 10%, after 10% dextrin mix homogeneously, using the ethanol of 85%-90% as wetting agent, wet granulation, dry, granulate, load capsule, obtain.
Described granule is prepared like this: get Semen Vignae Cylindricae KOUREN, Fructus Amomi, dry Rhizoma Zingiberis Recens, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, it is 40 object granules that Rhizoma Curcumae is pulverized respectively, the water that adds 8 times of amounts, with extraction by steam distillation volatile oil 3 hours, collect volatile oil, in medicinal residues and side, remaining medical material merges, add 8 times of water gagings, extract 3 times, each 1 hour, filter, dregs pressing, merge 3 times extracting solution, standing over night, the remove impurity of supernatant high speed centrifugation, the extractum that when medicinal liquid is concentrated into 60 ℃, relative density is 1.15-1.20, extractum is dry in 60 ℃, and be ground into fine powder, the cane sugar powder that adds the amount of making 15%, 15% dextrin and above-mentioned volatile oil mix, with 80% ethanol, it is wetting agent granule processed, dry in 60 ℃ after granulation, after 12 mesh sieve 1 time, and separate fine powder with 60 mesh sieves, obtain.
Described oral liquid is prepared like this: get Semen Vignae Cylindricae KOUREN, Fructus Amomi, dry Rhizoma Zingiberis Recens, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, it is 40 object granules that Rhizoma Curcumae is pulverized respectively, the water that adds 8 times of amounts, with extraction by steam distillation volatile oil 3 hours, collect volatile oil, in medicinal residues and side, remaining medical material merges, add 8 times of water gagings, extract 3 times, each 1 hour, filter, dregs pressing, merge 3 times extracting solution, standing over night, the remove impurity of supernatant high speed centrifugation, the extractum that when medicinal liquid is concentrated into 60 ℃, relative density is 1.10-1.15, the sucrose of separately getting the amount of making 40% adds in the water boiling to be made to be uniformly dissolved, filter, make simple syrup, simple syrup is added in standby extractum, add the sodium benzoate of the amount of making 0.2%, boil dissolving, add above-mentioned volatile oil to stir evenly, with pure water, be settled to full dose, stir evenly, filter, embedding, obtains oral liquid.
Pharmaceutical composition of the present invention is when making medicament, and the medicament of unit dose can contain pharmaceutically active substance 0.1-1000mg of the present invention, and all the other are pharmaceutically acceptable adjuvant.Pharmaceutically acceptable adjuvant can be the 0.1-99.9% of total formulation weight amount by weight.
Medicine of the present invention is prepared from by Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, Pericarpium Citri Reticulatae, Radix Ginseng, Polyporus, Poria, Massa Medicata Fermentata, Rhizoma Alismatis, dry Rhizoma Zingiberis Recens, the Rhizoma Atractylodis Macrocephalae, Semen Vignae Cylindricae KOUREN, Flos puerariae lobatae, Fructus Amomi, Carapax Trionycis, Rhizoma Curcumae, Rabdosia rubescens, Herba humuli scandentis, Radix Ranunculi Ternati, Herba Lysimachiae, Herba Hyperici Japonici and adjuvant.Wherein, Pericarpium Citri Reticulatae Viride is hot peel or the young fruit that do not become of the multiple Fructus Citri tangerinae classes such as Folium Symplocoris Caudatae profit plant tangerine produced in fujian province or Zhu's Fructus Citri tangerinae.Its nature and flavor toil, tepor, enters liver, gallbladder meridian, has soothing the liver dispelling the stagnated QI, eliminating stagnation expectorant.Be usually used in treating breast side of body gastralgia, hernia, food stagnation, swelling of the breast, nodule in the breast, the diseases such as chronic malaria addiction piece.The Radix Aucklandiae is the dry root of the feverfew Radix Aucklandiae.Its nature and flavor are pungent, hardship, and temperature, returns spleen, large intestine, tri-jiao channel.There is circulation of qi promoting, pain relieving, spleen invigorating, the effect helping digestion.Be usually used in promoting the circulation of QI to relieve pain; Intestinal stasis relieving in tune; Main born of the same parents coerce distension foot; Abdominal distention; Tell and have loose bowels; Heavy after dysentery, heavy after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, anorexia; Middle gas is not economized; Burst is deaf; Snake bite and insect sting; The diseases such as toothache.Pericarpium Citri Reticulatae is the mature peel of rutaceae orange and variety thereof.Nature and flavor temperature, pungent, bitter; Return spleen, lung meridian.There is regulating qi-flowing for strengthening spleen, in tune, dampness, the effect of reducing phlegm.Be usually used in the distension and fullness in the abdomen of stagnation of QI in spleen and stomach or pain, dyspepsia.Abdominal distention uncomfortable in chest, indigestion and loss of appetite loose stool in turbid damp resistance.Phlegm-damp is stopped up the diseases such as cough and asthma of lung.Radix Ginseng is the dry root of Araliaceae, Panax herbaceos perennial; Its sweet in the mouth, micro-hardship, slightly warm in nature, returns spleen, lung, the heart, kidney channel.There is invigorating QI to relieve exhaustion, spleen invigorating lung benefiting, mind calming Fructus Alpiniae Oxyphyllae, the effect of nourishing blood to promote the production of body fluid; Be usually used in treating serious disease, prolonged illness, lose blood, vigour wish is de-due to de-liquid, Mental fatigue faint pulse; The lack of appetite asthenia of deficiency of spleen-QI, vomiting is had loose bowels; The dyspnea with shortness of breath of insufficiency of lung-QI, coughs unable; The insomnia and dreamful sleep that insufficiency of heart-QI declines, palpitates with fear forgetful, the empty hyperhidrosis of body; Body fluid deficiency thirsty, quenches one's thirst; Blood deficiency sallow, dizzy; Impotence due to deficiency of the kidney, frequent micturition, the diseases such as deficiency of vital energy diseases caused by exogenous pathogenic factor.Polyporus is the dry sclerotia of On Polyporaceae Polyporus.Property slightly sweet flavor flat, return kidney, urinary bladder channel.The effect that has promoting diuresis to eliminate damp pathogen.Be used for the treatment of dysuria, edema, has loose bowels, and stranguria with turbid discharge is with inferior disease.Poria is the dry sclerotia of On Polyporaceae Poria.Nature and flavor are sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Have promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming obtains effect.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia waits disease.Massa Medicata Fermentata is after the medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran to mix, the herbal leaven forming through fermentation.Nature and flavor sweet, acrid, warm.Enter spleen, stomach warp.There is invigorating the spleen and regulating the stomach, the effect helping digestion in adjusting.Be used for controlling retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, postnatal blood stasis stomachache, the hard long-pending disease of waiting of children's's enlarged abdomen.Rhizoma Alismatis is the dry tuber of this plant of the perennial swampweed of Alismataceae Rhizoma Alismatis.Nature and flavor are sweet, cold.Return kidney, urinary bladder channel.There is diuresis, the effect of clearing away damp-heat.For dysuria, edema distension, the oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Modern study class is for diseases such as hyperlipidemia.Rhizoma Zingiberis is the dry rhizome of zingiber.Nature and flavor are pungent, heat.Return spleen, stomach, kidney, the heart, lung meridian.Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.For coldness and pain in the epigastrium, vomiting is had loose bowels, cold extremities faint pulse, and phlegm retention is breathed with cough.The Rhizoma Atractylodis Macrocephalae belongs to herbaceos perennial, root stock nodositas.Stem is upright, conventionally the long branch from middle and lower part, all Glabrous.The nice and cool weather of happiness, is used as medicine with rhizome, has invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis, antiabortive effect, for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.< < medicine origin > > records: " dehumidifying benefit is dry, and middle QI invigorating, and warming middle-JIAO goes to wet in taste, and except gastric heat, strong taste, enter diet, antiabortive." Fructus Amomi Rotundus is that Zingiberaceae is the dry mature fruit of Zingiberaceae herbaceos perennial Fructus Amomi Rotundus.Its property and flavor of peppery and warm, enters lung, spleen, stomach warp, has the merit of removing dampness warming middle-JIAO, activating QI to stop vomiting, especially with " temperatureization ", is good at.Be usually used in treating the diseases such as fullness in the epigastrium and chest due to dampness taste, disorder of movement of QI or Deficiency and coldness of spleen and stomach, anorexia, regurgitation vomiting, dirty and greasy fur.Flos puerariae lobatae is the dried floral of leguminous plant Pueraria lobota.Nature and flavor are sweet, flat.The effect that has relieving acute alcoholism and recuperating the spleen.For insobriety, headache, dizziness, excessive thirst.Chest and diaphragm is glutted, and acid regurgitation etc. injure the disease of gastric qi.In traditional Chinese medical science field, just there is saying of " thousand glasss of not liquor-saturated Pueraria lobata flowers ".Fructus Amomi is the fruits and seeds nature and flavor of zingiberaceous plant Amomum xanthioides spring arenaceous shell sand: acrid in the mouth, and warm in nature.Return spleen channel, stomach warp, kidney channel.There is removing dampness appetizing, warming spleen and stopping diarrha, the antiabortive effect of regulating the flow of vital energy.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.Carapax Trionycis salty in the mouth, is slightly cold, and returns liver, kidney channel; Have nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, brings down a fever except the effect of steaming, for fever due to yin deficiency, and consumptive fever hectic fever due to YIN-deficiency, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea ， WEIJIA, chronic malaria malaria with splenomegaly.Modern pharmacological research demonstration, Carapax Trionycis has resisting fatigue, immunologic enhancement and antitumor action.Rhizoma Curcumae acrid in the mouth, hardship, warm in nature, return liver, spleen channel, there are removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving, promoting the circulation of QI to relieve pain, the effect of removing blood stasis removing food stagnancy and promoting digestion and removing stagnation; Main containing volatile oil in rhizome, there are antitumor action, antiearly pregnancy effect, antibacterial action etc.Rabdosia rubescens bitter in the mouth, sweet, be slightly cold, heat clearing away, removing toxic substances, promoting blood circulation and stopping pain, for laryngopharynx swelling and pain, tonsillitis, snake bite and insect sting, rheumatic ostalgia etc.Main Function has: antitumor, antibacterial action are conciliate the effects such as heat drop is dry.Research find Rabdosia rubescens also have antipyretic, fall dryly wet one's whistle, the effect such as blood fat reducing, blood pressure lowering.Cold, fever, aphtha of the mouth and tongue, burnt heat are got angry etc. and to be had good preventive and therapeutic action.Herba humuli scandentis has heat-clearing and toxic substances removing, the effect of inducing diuresis to remove edema.For pulmonary tuberculosis hectic fever, gastroenteritis, dysentery, cold, fever, dysuria, pyelonephritis, acute nephritis, cystitis, urinary system calculus; Carbuncle furuncle and phyma poison, eczema, venom are controlled in external.Radix Ranunculi Ternati sweet in the mouth is pungent, warm in nature.Enter liver, lung two warps; Have dissipating phlegm and resolving masses, the effect of removing toxic substances and promoting subsidence of swelling, controls pulmonary tuberculosis, malaria, scrofula sucutaneous nodule, furuncle, worm venom, migraine, malaria, toothache.Tuberculous lymphadenitis, lymphadenitis, pharyngolaryngitis.Herba Lysimachiae original name Herba Dichodrae, sweet in the mouth, micro-hardship, cool in nature.Return liver, gallbladder, kidney, urinary bladder channel; Herb hyoscine, has the merit of clearing away heat and promoting diuresis, wind-expelling pain-stopping, hemostasia and promoting granulation, eliminating inflammation and expelling toxin, parasite killing.Can treating acute and chronic hepatitis, icterohepatitis, cholecystitis, nephritis, urinary system infection, tonsillitis, stomatitis and carbuncle furuncle are treated poison, venom, acute mastitis, dysentery, malaria, pneumorrhagia etc.Herba Hyperici Japonici is the dry herb of Guttiferae hypericum Herba Hyperici Japonici Hypericumjaponicum Thunb.; Sweet in the mouth, micro-hardship, cold nature, returns liver, spleen channel.There is heat-clearing and toxic substances removing, dampness removing jaundice eliminating, the effect of detumescence dissipating blood stasis; For jaundice due to damp-heat, acute appendicitis, conjunctival congestion and swelling pain, hot carbuncle toxin etc.Each medicine is played regulating qi-flowing for strengthening spleen altogether above, divides the wet effect of wine that disappears.For wet imapirment of the spleen and stomach, insobriety.
In side, the Six-element Chinese medicine such as Semen Vignae Cylindricae KOUREN, Fructus Amomi, Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, Rhizoma Curcumae contains abundant volatile ingredient, if the borneol acetate in Fructus Amomi, the eucalyptole in Fructus Amomi Rotundus etc. are all effective active compositions, therefore in preparation process, adopt that steam distillation first extracts volatile oil, after separation, medicinal residues again with the common formulation process method extracting of other medical material.Because considering the needs of large production, from clinical practice angle, consider to adopt water extraction process to obtain extracting solution, medical material can be dissolved out effective ingredient substantially through extracted twice, but extraction process by water is subject to the impact of a lot of conditions to a certain extent.As amount of water, decoction number of times, decocting time etc.For this reason, we adopt orthogonal experimental design method, filter out best extraction process condition.
The present invention has carried out a large amount of experimentatioies, is below the result of experimentation of the present invention:
Experimental example 1: technical study
1 orthogonal test factor level arranges
1.1 Extraction Process of Volatile Oils are preferred
Degree of grinding (A) with medical material, adds water multiple (B), and soak time (C) is boiled the time of putting forward (D) four factors, and every factor is equipped with 3 levels for investigating index.Take respectively roud cardamon seed 45g, Fructus Amomi 45g, Rhizoma Zingiberis 18g, Radix Aucklandiae 4.5g, Pericarpium Citri Reticulatae 13.5g, Pericarpium Citri Reticulatae Viride 2.7g, Rhizoma Atractylodis Macrocephalae 18g, Rhizoma Curcumae 15g, carry out orthogonal experiment by table 2.
Table 1 factor level
According to the arrangement of appeal factor level, adopt L
9(3
7) table arrangement orthogonal test, using volatile oil yield as evaluation index, preferred best extraction process, in Table 2.
Table 2
Optimised process is as shown in Table 2: A
2b
2c
1d
3.Be that degree of grinding is 40 orders:, adding water multiple is 8 times, and soak time is 0h, and boiling the time of carrying is 3h.
1.2 extract medicinal residues and other medicinal material extract optimal processes after volatile oil
To add water multiple (A), to boil, carry number of times (B), boil the time of putting forward (C) three factors, every factor is equipped with 3 levels for investigating index.Take Radix Ginseng 13.5g, Polyporus 13.5g, Poria 13.5g, Massa Medicata Fermentata 18g, Rhizoma Alismatis 18g, Rhizoma Atractylodis Macrocephalae 18g, Flos puerariae lobatae 45g, Carapax Trionycis 50g, Rabdosia rubescens 50g, Herba humuli scandentis 50g, Radix Ranunculi Ternati 50g, Herba Lysimachiae 50g, Herba Hyperici Japonici 50g, by table 4, carry out orthogonal experiment.
Table 3
According to the arrangement of appeal factor level, adopt L
9(3
4) table arrangement orthogonal test, using paste-forming rate and total flavones amount as evaluation index, preferred best extraction process, in Table 4
Table 4
Note: press L
9(3
4) show to extract, precision is drawn equivalent concentrated solution 25mL respectively.Be placed in the evaporating dish (W that is dried to constant weight
1), water bath method, dry 3h, moves in exsiccator at 105 ℃, cooling 30min, rapidly accurately weighed its quality (W
2), calculate as follows yield of extract, orthogonal experiments is in Table 4.
The mensuration of general flavone content adopts ultraviolet spectrophotometry, take puerarin as reference substance, and at 250nm wavelength, place is measured.
By table 4, analyzed, optimised process is: A
1b
3c
1.Add 8 times of water, extract 3 times, each 1h.
Embodiment 2: pharmacodynamic study
1 hepatoprotective effect
1.1 laboratory animals adopt 50 of Wistar rats, and body weight 180-200g is male.
1.2 medicines, reagent and instrument adopt the preparation method of embodiment 1 to make soft extract, and adding distil water is made the solution of 2g/mL.High dose administration group is 0.64g/mL, and low dose group is 0.16g/mL.DONGBAO GANTAI sheet, is produced by Tonghua Dongbao Pharmaceutical Co., Ltd, specification: 48, every box, substrate is heavily 0.4g.With distilled water, be made into the solution use that concentration is 0.036g/mL.56 ° of Red Star strong, colourless liquor distilled from sorghum, Beijing Red Star wine brewing limited company produces (lot number: 20070424); 20070615), malonaldehyde (MDA) test kit (lot number: 20070619), glutathion (GSH) test kit (lot number: 20071108) all build up Bioengineering Research Institute purchased from Nanjing superoxide dismutase (SOD) is measured test kit (lot number:.
The common instruments such as analytical balance.
1.3 experiment content
By giving the method for rat Chinese liquor gavage every day, copy alcohol-induced liver injury in rats model.110 rats are divided at random to 5 groups after adapting to raising 4d: blank group (N); Model group (M), medicine low dose group of the present invention, medicine high dose group of the present invention, positive control drug DONGBAO GANTAI sheet (GT) group, each 10.Except normal nursing, press 1mL/100g gavage respectively morning every day: blank group gavage distilled water; Medicine group gavage soft extract of the present invention, soft extract adding distil water is made solution; The sweet safe sheet aqueous solution of sweet safe sheet group gavage 0.036g/mL, every day 1 time.3h after each administration, except blank group to distilled water, all the other each groups are all used the strong, colourless liquor distilled from sorghum Chinese liquor gavage of 56 °, and consumption first week is 0.8mL/100g, increases weekly 0.1mL (until increasing to 1.5mL/100g) later, and gavage is 8 weeks continuously.The 8th weekend, the equal fasting 12h of all rats, abdominal aortic blood.Animal is got after blood, at once takes out whole liver, weighs, and gets leftlobe of liver and organizes about 0.2g, is prepared into 10% liver homogenate after the normal saline flushing with pre-cooling, standby SOD, MDA, the GSH of surveying, and its detection all operates by test kit description.The results are shown in Table 5
Table 5
Note: with the comparison of blank group, * P<0.05, * * * P<0.001; Compare #P<0.05, ##<0.01. with model group
By above experimental result, shown, the hepatic tissue SOD activity of medicine group of the present invention and sweet safe sheet group is significantly higher than model group and close to normal level (P<0.01, P<0.05); This Liver MDA of two groups compared with model group by remarkable decline (P<0.05, P<0.01); This hepatic tissue GSH content of two groups compared with model group by obvious raising (P<0.05).Illustrate that medicine of the present invention has the effect of obvious control alcoholic liver injury, i.e. hepatoprotective effect.
Experimental example 3: anxious malicious experimentation
1 experimental technique
Kunming mouse, through prerun, gives the equal 1mL/20g of gavage of white mice pharmaceutical composition unguentum of the present invention, do not cause death, the concentration and the administration volume that are limited to medicine can not increase, and can not measure median lethal dose(LD 50) (LD50), therefore carry out maximum tolerance determination experiment.
Select 20 of healthy Kunming mouses, weight (20 ± 2) g, male and female half and half, with 24 hours in minute gavage pharmaceutical composition unguentum of the present invention for 2 times, 1mL/ time, always measure and reach 100mL/kg, be equivalent to 163g/kg crude drug.This dosage is equivalent to 200 times of Coming-of-Age Day dosing.
2 experimental results
Mice, to observation post administration 7 days, has no untoward reaction, whole bouncings, and Weight gain, without dead.
Compared with prior art, the present invention selects Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, Pericarpium Citri Reticulatae, Radix Ginseng, Polyporus, Poria, Massa Medicata Fermentata, Rhizoma Alismatis, dry Rhizoma Zingiberis Recens, the Rhizoma Atractylodis Macrocephalae, Semen Vignae Cylindricae KOUREN, Flos puerariae lobatae, Fructus Amomi, Carapax Trionycis, Rhizoma Curcumae, Rabdosia rubescens, Herba humuli scandentis, Radix Ranunculi Ternati, Herba Lysimachiae, Herba Hyperici Japonici and adjuvant to be prepared from.It is wet that described medicine has the wine that minute disappears, the effect of regulating qi-flowing for strengthening spleen, and to the wine painful abdominal mass plug that amasss, vomits, has loose bowels, headache, dysuria etc. have definite curative effect, and the curative effect of medication of making is remarkable, has no side effect, and has reached goal of the invention.
Further illustrate by the following examples the present invention, but not as limitation of the present invention.
The specific embodiment:
Embodiment 1:
Prescription: Pericarpium Citri Reticulatae Viride 27g, Radix Aucklandiae 45g, Pericarpium Citri Reticulatae 135g, Radix Ginseng 135g, Polyporus 135g, Poria 135g, Massa Medicata Fermentata 180g, Rhizoma Alismatis 180g, dry Rhizoma Zingiberis Recens 180g, Rhizoma Atractylodis Macrocephalae 180g, Semen Vignae Cylindricae KOUREN 450g, Flos puerariae lobatae 450g, Fructus Amomi 450g, Carapax Trionycis 500g, Rhizoma Curcumae 150g, Rabdosia rubescens 500g, Herba humuli scandentis 500g, Radix Ranunculi Ternati 500g, Herba Lysimachiae 500g, Herba Hyperici Japonici 500g.
Technique: get Semen Vignae Cylindricae KOUREN, Fructus Amomi, dry Rhizoma Zingiberis Recens, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Rhizoma Curcumae is pulverized is respectively 40 object granules, adds the water of 8 times of amounts, with extraction by steam distillation volatile oil 3 hours, collect volatile oil, in medicinal residues and side, remaining medical material merges, and adds 8 times of water gagings, extract 3 times, each 1 hour, filter dregs pressing, merge 3 times extracting solution, standing over night, the remove impurity of supernatant high speed centrifugation, the extractum that when medicinal liquid is concentrated into 60 ℃, relative density is 1.15-1.20; Separately get the Mel of 600g, add in extractum, stir, with slow fire heating, receive cream, waiting to get a little can horizontal drawing filamentation, or while dripping on paper not water breakthrough mark, adds volatile oil, stirs evenly, and obtains soft extract.
Usage and dosage: oral, sooner or later each once (before or after meals all can), each 15g, puts into hot water and melts rear oral; Also can directly swallow.
Embodiment 2:
Prescription: Pericarpium Citri Reticulatae Viride 50g, Radix Aucklandiae 60g, Pericarpium Citri Reticulatae 150g, Radix Ginseng 150g, Polyporus 150g, Poria 150g, Massa Medicata Fermentata 200g, Rhizoma Alismatis 200g, dry Rhizoma Zingiberis Recens 200g, Rhizoma Atractylodis Macrocephalae 200g, Semen Vignae Cylindricae KOUREN 500g, Flos puerariae lobatae 500g, Fructus Amomi 500g, Carapax Trionycis 600g, Rhizoma Curcumae 200g, Rabdosia rubescens 600g, Herba humuli scandentis 600g, Radix Ranunculi Ternati 600g, Herba Lysimachiae 600g, Herba Hyperici Japonici 600g.
Technique: get Semen Vignae Cylindricae KOUREN, Fructus Amomi, dry Rhizoma Zingiberis Recens, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, it is 40 object granules that Rhizoma Curcumae is pulverized respectively, the water that adds 8 times of amounts, with extraction by steam distillation volatile oil 3 hours, collect volatile oil, in medicinal residues and side, remaining medical material merges, add 8 times of water gagings, extract 3 times, each 1 hour, filter, dregs pressing, merge 3 times extracting solution, standing over night, the remove impurity of supernatant high speed centrifugation, the extractum that when medicinal liquid is concentrated into 60 ℃, relative density is 1.15-1.20, 70 ℃ of drying under reduced pressure become dry extract, pulverize, add above-mentioned volatile oil, the Icing Sugar of the amount of making 10%, after 10% dextrin mix homogeneously, using the ethanol of 85%-90% as wetting agent, wet granulation, dry, granulate, load capsule, obtain capsule.
Usage and dosage: oral, one time 3,3 times on the one.
Embodiment: 3:
Prescription: Pericarpium Citri Reticulatae Viride 15g, Radix Aucklandiae 30g, Pericarpium Citri Reticulatae 100g, Radix Ginseng 100g, Polyporus 100g, Poria 100g, Massa Medicata Fermentata 150g, Rhizoma Alismatis 150g, dry Rhizoma Zingiberis Recens 150g, Rhizoma Atractylodis Macrocephalae 150g, Semen Vignae Cylindricae KOUREN 300g, Flos puerariae lobatae 300g, Fructus Amomi 300g, Carapax Trionycis 400g, Rhizoma Curcumae 100g, Rabdosia rubescens 400g, Herba humuli scandentis 400g, Radix Ranunculi Ternati 400g, Herba Lysimachiae 400g, Herba Hyperici Japonici 400g.
Technique: get Semen Vignae Cylindricae KOUREN, Fructus Amomi, dry Rhizoma Zingiberis Recens, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, it is 40 object granules that Rhizoma Curcumae is pulverized respectively, the water that adds 8 times of amounts, with extraction by steam distillation volatile oil 3 hours, collect volatile oil, in medicinal residues and side, remaining medical material merges, add 8 times of water gagings, extract 3 times, each 1 hour, filter, dregs pressing, merge 3 times extracting solution, standing over night, the remove impurity of supernatant high speed centrifugation, the extractum that when medicinal liquid is concentrated into 60 ℃, relative density is 1.15-1.20, extractum is dry in 60 ℃, and be ground into fine powder, the cane sugar powder that adds the amount of making 15%, 15% dextrin and above-mentioned volatile oil mix, with 80% ethanol, it is wetting agent granule processed, dry in 60 ℃ after granulation, after 12 mesh sieve 1 time, and separate fine powder with 60 mesh sieves, obtain granule.
Usage and dosage: take a 10g, 3 times on the one after mixing it with hot water.
Embodiment: 4:
Prescription: Pericarpium Citri Reticulatae Viride 50g, Radix Aucklandiae 60g, Pericarpium Citri Reticulatae 150g, Radix Ginseng 100g, Polyporus 100g, Poria 150g, Massa Medicata Fermentata 150g, Rhizoma Alismatis 150g, dry Rhizoma Zingiberis Recens 200g, Rhizoma Atractylodis Macrocephalae 200g, Semen Vignae Cylindricae KOUREN 300g, Flos puerariae lobatae 300g, Fructus Amomi 500g, Carapax Trionycis 400g, Rhizoma Curcumae 100g, Rabdosia rubescens 600g, Herba humuli scandentis 400g, Radix Ranunculi Ternati 400g, Herba Lysimachiae 400g, Herba Hyperici Japonici 600g.
Technique: get Semen Vignae Cylindricae KOUREN, Fructus Amomi, dry Rhizoma Zingiberis Recens, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, it is 40 object granules that Rhizoma Curcumae is pulverized respectively, the water that adds 8 times of amounts, with extraction by steam distillation volatile oil 3 hours, collect volatile oil, in medicinal residues and side, remaining medical material merges, add 8 times of water gagings, extract 3 times, each 1 hour, filter, dregs pressing, merge 3 times extracting solution, standing over night, the remove impurity of supernatant high speed centrifugation, the extractum that when medicinal liquid is concentrated into 60 ℃, relative density is 1.10-1.15, the sucrose of separately getting the amount of making 40% adds in the water boiling to be made to be uniformly dissolved, filter, make simple syrup, simple syrup is added in standby extractum, add the sodium benzoate of the amount of making 0.2%, boil dissolving, add above-mentioned volatile oil to stir evenly, with pure water, be settled to 10L, stir evenly, filter, embedding, obtains oral liquid.
Usage and dosage: oral, a 15ml, 3 times on the one.
Claims (9)
1. the medicine relieving the effect of alcohol, it is characterized in that: according to composition by weight, calculate, by Pericarpium Citri Reticulatae Viride 15-50 part, Radix Aucklandiae 30-60 part, Pericarpium Citri Reticulatae 100-150 part, Radix Ginseng 100-150 part, Polyporus 100-150 part, Poria 100-150 part, Massa Medicata Fermentata 150-200 part, Rhizoma Alismatis 150-200 part, dry Rhizoma Zingiberis Recens 150-200 part, Rhizoma Atractylodis Macrocephalae 150-200 part, Semen Vignae Cylindricae KOUREN 300-500 part, Flos puerariae lobatae 300-500 part, Fructus Amomi 300-500 part, Carapax Trionycis 400-600 part, Rhizoma Curcumae 100-200 part, Rabdosia rubescens 400-600 part, Herba humuli scandentis 400-600 part, Radix Ranunculi Ternati 400-600 part, Herba Lysimachiae 400-600 part, Herba Hyperici Japonici 400-600 part and adjuvant are prepared from.
2. the medicine relieving the effect of alcohol as claimed in claim 1, it is characterized in that: according to composition by weight, calculate, by 27 parts, Pericarpium Citri Reticulatae Viride, 45 parts of the Radix Aucklandiae, 135 parts of Pericarpium Citri Reticulataes, 135 parts of Radix Ginsengs, 135 parts of Polyporus, 135 parts of Porias, 180 parts of Massa Medicata Fermentata, 180 parts of Rhizoma Alismatis, 180 parts, dry Rhizoma Zingiberis Recens, 180 parts of the Rhizoma Atractylodis Macrocephalaes, 450 parts of Semen Vignae Cylindricae KOUREN, 450 parts of Flos puerariae lobataes, 450 parts of Fructus Amomis, 500 parts of Carapax Trionycis, 150 parts of Rhizoma Curcumae, 500 parts of Rabdosia rubescens, 500 parts of Herba humuli scandentis, 500 parts of Radix Ranunculi Ternatis, 500 parts of Herba Lysimachiaes, 500 parts of Herba Hyperici Japonici and adjuvant, be prepared from.
3. the method for the medicine relieving the effect of alcohol described in preparation claim 1 or 2, is characterized in that: proportionally take each medical material, combine, and process according to conventional preparation method with acceptable pharmaceutic adjuvant in medicine, make corresponding pharmaceutical preparation.
4. the preparation method of the medicine relieving the effect of alcohol as claimed in claim 3, it is characterized in that: get Semen Vignae Cylindricae KOUREN, Fructus Amomi, dry Rhizoma Zingiberis Recens, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, it is 40 object granules that Rhizoma Curcumae is pulverized respectively, the water that adds 8 times of amounts, with extraction by steam distillation volatile oil 3 hours, collect volatile oil, in medicinal residues and side, remaining medical material merges, add 8 times of water gagings, extract 3 times, each 1 hour, filter, dregs pressing, merge 3 times extracting solution, standing over night, the remove impurity of supernatant high speed centrifugation, medicinal liquid is condensed into extractum, combine with acceptable pharmaceutic adjuvant in above-mentioned volatile oil and medicine, and process according to conventional preparation method, make corresponding pharmaceutical preparation.
5. the preparation method of the medicine relieving the effect of alcohol as described in claim 3 or 4, is characterized in that: described pharmaceutical preparation is soft extract, hard capsule, ointment, tablet, granule, pill, oral liquid, syrup, powder, sublimed preparation, suspensoid, solution, injection, freeze-dried powder, bulk capacity injection, suppository, plaster, cream, spray or patch.
6. the preparation method of the medicine relieving the effect of alcohol as claimed in claim 5, is characterized in that: described pharmaceutical preparation is soft extract, capsule, granule or oral liquid.
7. the preparation method of the medicine relieving the effect of alcohol as claimed in claim 6, it is characterized in that: described soft extract is prepared like this: get Semen Vignae Cylindricae KOUREN, Fructus Amomi, dry Rhizoma Zingiberis Recens, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, it is 40 object granules that Rhizoma Curcumae is pulverized respectively, the water that adds 8 times of amounts, with extraction by steam distillation volatile oil 3 hours, collect volatile oil, in medicinal residues and side, remaining medical material merges, add 8 times of water gagings, extract 3 times, each 1 hour, filter, dregs pressing, merge 3 times extracting solution, standing over night, the remove impurity of supernatant high speed centrifugation, the extractum that when medicinal liquid is concentrated into 60 ℃, relative density is 1.15-1.20, separately get the Mel of the amount of making 10-50%, add in extractum, stir, with slow fire heating, receive cream, waiting to get a little can horizontal drawing filamentation, or while dripping on paper not water breakthrough mark, adds volatile oil, stirs evenly, and obtains.
8. the preparation method of the medicine relieving the effect of alcohol as claimed in claim 6, it is characterized in that: described capsule is prepared like this: get Semen Vignae Cylindricae KOUREN, Fructus Amomi, dry Rhizoma Zingiberis Recens, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, it is 40 object granules that Rhizoma Curcumae is pulverized respectively, the water that adds 8 times of amounts, with extraction by steam distillation volatile oil 3 hours, collect volatile oil, in medicinal residues and side, remaining medical material merges, add 8 times of water gagings, extract 3 times, each 1 hour, filter, dregs pressing, merge 3 times extracting solution, standing over night, the remove impurity of supernatant high speed centrifugation, the extractum that when medicinal liquid is concentrated into 60 ℃, relative density is 1.15-1.20, 70 ℃ of drying under reduced pressure become dry extract, pulverize, add above-mentioned volatile oil, the Icing Sugar of the amount of making 10%, after 10% dextrin mix homogeneously, using the ethanol of 85%-90% as wetting agent, wet granulation, dry, granulate, load capsule, obtain.
9. the preparation method of the medicine relieving the effect of alcohol as claimed in claim 6, it is characterized in that: described granule is prepared like this: get Semen Vignae Cylindricae KOUREN, Fructus Amomi, dry Rhizoma Zingiberis Recens, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, it is 40 object granules that Rhizoma Curcumae is pulverized respectively, the water that adds 8 times of amounts, with extraction by steam distillation volatile oil 3 hours, collect volatile oil, in medicinal residues and side, remaining medical material merges, add 8 times of water gagings, extract 3 times, each 1 hour, filter, dregs pressing, merge 3 times extracting solution, standing over night, the remove impurity of supernatant high speed centrifugation, the extractum that when medicinal liquid is concentrated into 60 ℃, relative density is 1.15-1.20, extractum is dry in 60 ℃, and be ground into fine powder, the cane sugar powder that adds the amount of making 15%, 15% dextrin and above-mentioned volatile oil mix, with 80% ethanol, it is wetting agent granule processed, dry in 60 ℃ after granulation, after 12 mesh sieve 1 time, and separate fine powder with 60 mesh sieves, obtain.10. the preparation method of the medicine relieving the effect of alcohol as claimed in claim 6, it is characterized in that: described oral liquid is prepared like this: get Semen Vignae Cylindricae KOUREN, Fructus Amomi, dry Rhizoma Zingiberis Recens, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, it is 40 object granules that Rhizoma Curcumae is pulverized respectively, the water that adds 8 times of amounts, with extraction by steam distillation volatile oil 3 hours, collect volatile oil, in medicinal residues and side, remaining medical material merges, add 8 times of water gagings, extract 3 times, each 1 hour, filter, dregs pressing, merge 3 times extracting solution, standing over night, the remove impurity of supernatant high speed centrifugation, the extractum that when medicinal liquid is concentrated into 60 ℃, relative density is 1.10-1.15, the sucrose of separately getting the amount of making 40% adds in the water boiling to be made to be uniformly dissolved, filter, make simple syrup, simple syrup is added in standby extractum, add the sodium benzoate of the amount of making 0.2%, boil dissolving, add above-mentioned volatile oil to stir evenly, with pure water, be settled to full dose, stir evenly, filter, embedding, obtains oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410304905.8A CN104056234A (en) | 2014-06-30 | 2014-06-30 | Drug for dispelling alcohol effect and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410304905.8A CN104056234A (en) | 2014-06-30 | 2014-06-30 | Drug for dispelling alcohol effect and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104056234A true CN104056234A (en) | 2014-09-24 |
Family
ID=51544353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410304905.8A Pending CN104056234A (en) | 2014-06-30 | 2014-06-30 | Drug for dispelling alcohol effect and preparing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104056234A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106620282A (en) * | 2016-12-23 | 2017-05-10 | 赤水市信天中药产业开发有限公司 | Herba dendrobii nobilis and American ginseng capsules and preparation method thereof |
| CN111821415A (en) * | 2020-08-12 | 2020-10-27 | 马小舟 | Traditional Chinese medicine for dispelling effects of alcohol and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1973895A (en) * | 2006-09-06 | 2007-06-06 | 陈昊 | Medicine for sober-up and treating acute alcoholism and its prepn |
| CN101306190A (en) * | 2008-06-14 | 2008-11-19 | 王跃进 | Kudzuvine flower de-inebriating capsules |
| CN101623489A (en) * | 2008-07-08 | 2010-01-13 | 张成赟 | Chinese medicinal composition for treating vomiting and diarrhea after drinking |
| CN101890147A (en) * | 2009-05-22 | 2010-11-24 | 陈亮 | Dealcoholic traditional Chinese medicinal composition |
| CN102698083A (en) * | 2012-07-04 | 2012-10-03 | 贵阳中医学院 | Oldenlandia liver-tonifying and toxicity-eliminating particles and preparation method thereof, as well as detection method |
-
2014
- 2014-06-30 CN CN201410304905.8A patent/CN104056234A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1973895A (en) * | 2006-09-06 | 2007-06-06 | 陈昊 | Medicine for sober-up and treating acute alcoholism and its prepn |
| CN101306190A (en) * | 2008-06-14 | 2008-11-19 | 王跃进 | Kudzuvine flower de-inebriating capsules |
| CN101623489A (en) * | 2008-07-08 | 2010-01-13 | 张成赟 | Chinese medicinal composition for treating vomiting and diarrhea after drinking |
| CN101890147A (en) * | 2009-05-22 | 2010-11-24 | 陈亮 | Dealcoholic traditional Chinese medicinal composition |
| CN102698083A (en) * | 2012-07-04 | 2012-10-03 | 贵阳中医学院 | Oldenlandia liver-tonifying and toxicity-eliminating particles and preparation method thereof, as well as detection method |
Non-Patent Citations (2)
| Title |
|---|
| 伍嘉宁等: ""葛花解醒汤抗乙醇中毒的研究"", 《中国中西医结合杂志 1995年基础理论研究特集》 * |
| 苗彦妮 等: ""葛花对大鼠酒精性肝损伤的预防作用研究"", 《科技导报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106620282A (en) * | 2016-12-23 | 2017-05-10 | 赤水市信天中药产业开发有限公司 | Herba dendrobii nobilis and American ginseng capsules and preparation method thereof |
| CN111821415A (en) * | 2020-08-12 | 2020-10-27 | 马小舟 | Traditional Chinese medicine for dispelling effects of alcohol and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101698028B (en) | Fat-reducing and weight-losing composite and preparation method thereof | |
| CN104435775A (en) | Chinese medicinal health-care spirit and preparation method thereof | |
| CN103656238A (en) | Traditional Chinese medicine composition for treating rheumatic bone diseases | |
| CN104338043B (en) | A kind of medicine for improving immunity and preparation method thereof | |
| CN103690919A (en) | Medicine for treating piglet iron-deficiency anemia and preparation method of medicine | |
| CN101607051B (en) | Traditional Chinese medicine composition for losing weight and preparation method thereof | |
| CN101805687A (en) | Radix rehmanniae health care wine and production method thereof | |
| CN103301413A (en) | Traditional Chinese medicine composition for treating hyperlipemia and hyperglycemia | |
| CN103301267B (en) | Traditional Chinese medicine composition for treating hypertension and/or atherosclerosis and application thereof | |
| CN101011562B (en) | Novel formulation of shenqiwendan decoction and production method thereof | |
| CN104208623A (en) | Yao-nationality bathing medicine with effect of enhancing health after delivery of women and preparation method thereof | |
| CN103877438B (en) | Traditional Chinese medicine preparation for treating gout and production method thereof | |
| CN106215118A (en) | Antineoplastic health preparation and preparation method thereof | |
| CN105343593A (en) | Spica prunellae health oral liquid capable of decreasing blood pressure and blood lipid as well as preparation method of spica prunellae health oral liquid | |
| CN104056234A (en) | Drug for dispelling alcohol effect and preparing method thereof | |
| CN105211441A (en) | Red sage root leaf health-care tea of a kind of hypertension and hyperlipemia and preparation method thereof | |
| CN106994141B (en) | Traditional Chinese medicine composition for treating constipation and preparation method thereof | |
| CN104906507A (en) | Traditional Chinese medicine combination for lowering blood pressure and toning physical fitness | |
| CN104127683A (en) | Traditional Chinese medicine composition for treating or preventing female postmenopausal osteoporosis | |
| CN103690869B (en) | Chinese medicine for the treatment of irritable bowel syndrome and preparation method thereof | |
| CN105056170A (en) | Application of traditional Chinese medicine composition in preparing drug for treating acute gastritis | |
| CN104107308A (en) | Medicament for treating haemorrhoids and preparation method thereof | |
| CN108142930A (en) | For improving the Chinese herbal ointment formula of damp-heat constitution and its processing method | |
| CN102327549A (en) | Chinese herbal medicine for treating palpitation due to yin deficiency and liver depression induced by heart-qi deficiency | |
| CN103417836B (en) | Chinese medicine composition for the treatment of tumor and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140924 |
|
| RJ01 | Rejection of invention patent application after publication |