CN101007058B - Medicinal composition for treating bronchial asthma, chronic bronchitis and emphysema - Google Patents
Medicinal composition for treating bronchial asthma, chronic bronchitis and emphysema Download PDFInfo
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- CN101007058B CN101007058B CN200610023544A CN200610023544A CN101007058B CN 101007058 B CN101007058 B CN 101007058B CN 200610023544 A CN200610023544 A CN 200610023544A CN 200610023544 A CN200610023544 A CN 200610023544A CN 101007058 B CN101007058 B CN 101007058B
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Abstract
The invention relates to a medicinal composition for treating bronchial asthma, chronic bronchitis and pulmonary emphysema, which is prepared from Chinese ephedra, baikal skullcap root, tabasheer seeds, thorny elaeagnus leaf, scorpion and lepidium seed.
Description
Technical field
The present invention relates to a kind of compound medicament composition that comes from the treatment cough with asthma of Chinese medicine, be specifically related to treat the pharmaceutical composition of chronic bronchitis, bronchial asthma and emphysema.
Background technology
Bronchial asthma is a kind of chronic respiratory tract disease of common multiple, serious harm health.According to the literature, the pathogenesis of asthma rate from China 1% to Zelanian 13%, Philippine even reach 17%, and still have the trend of increase.The medical expense that its dispensary needs also is surprising, reach more than 4,000,000,000 dollars as the spending of U.S.'s year, Britain is more than 800,000,000 pounds, Brazil be more than 5,000 ten thousand dollars (Zhong Nanshan's (arrangement). international " global asthma control strategy is proposed " the seminar summary of promoting. Chinese tuberculosis and breathe magazine, 2000,23 (6): 330-331).China's five metropolitan teenager asthma prevalence are 3.3%-5.5%, be high far beyond (about 1%) before 10 years, and mortality rate increase.The prevalence of Shanghai childhood asthma from 1.92% of nineteen ninety rise to 2000 4.52% (Chinese medicine bronchial asthma information and analysis. Chinese Chinese medicine information magazine .1995,2 (8): 21-23).Deng Weiwu introduces, and just with the speed increase in every year 10%, every year is died from asthma up to 180,000 people in the whole world to present asthma prevalence from the whole world.The chronic episode process repeatedly of asthma and asthmatic patient and family members' body and mind thereof and loss and influence economic and that society causes caused global concern.
Bronchial asthma is the complicated clinical syndrome of infective inflammation and allergic inflammation, be airway reactivity inflammation and airway hyperreactivity based on the reaction of eosinophilic granulocyte, the mastocyte disease that is feature (Chen Haozhu. internal medicine. the 4th edition. Beijing: the People's Health Publisher, 1996:32).The treatment of asthma target is to reduce to the side effect of treatment minimum when reducing airway inflammation and protection.Treatment of asthma be subjected to again genetic background, individual factors, regions resources,, keep pulmonary function economic situation and all multifactor impacts such as disease accompanied.Therefore choose reasonable medication in treating asthma, with minimum dose, minimum economic burden reach optimum curative effect be crucial (Wu Ling, Rong Lei. the THE TREATMENT OF BRONCHIAL ASTHMA progress. practical general family medicine .2005,3 (2): 173-174).
Doctor trained in Western medicine is first-selected at present sucks antiphlogistic adrenocortical hormone, and cooperates β
2Receptor agonist, anticholinergic agents, theophylline class medicine, leukotriene antagonist etc. are treated. and suck 17-hydroxy-11-dehydrocorticosterone and be considered to treat at present asthma safe and effective procedure the most, but to the partial stimulation of throat and suppress adrenocortical side effect by the increasing doctor (Gao Hong that pays close attention to of family, Liu Shiying, Lin Zhifeng. the side effect that sucks hydrocortisone treatment childhood asthma is observed. the Chinese department of pediatrics .1998 of periodical publisher; 36 (12): 755; Gu Xuefan. the prognosis of acute bronchial asthma and the cause of death thereof. foreign medical science pediatrics fascicle, 1985; (1): 29-32; Zhu Ruiqun, Wang Yiqin, Gong Bin etc., the 1128 routine clinical observations of herbal application iontophoresis asthma. journal of shanghai Chinese medicine .1992; 4:21-23). and have document to point out, nearly more than ten years asthma case fatality rate rises and may change relevant with the treating asthma scheme, toxic action with theophylline, the side effect of bronchiectasis aerosol and intend sympathetic dose " spring syndrome " etc. relevant (Chinese medicine bronchial asthma information and analysis. Chinese Chinese medicine information magazine .1995,2 (8): 21-23). Chinese medicine has accumulated rich experience to treatment of asthma and prevention, Chinese medicine, acupuncture, the qigong, new therapys such as point application are to treatment of asthma and prevent that much gratifying reports are arranged (Gu Xuefan. the prognosis of acute bronchial asthma and the cause of death thereof. foreign medical science pediatrics fascicle, 1985; (1): 29-32; Zhu Ruiqun, Wang Yiqin, Gong Bin etc., the 1128 routine clinical observations of herbal application iontophoresis asthma. journal of shanghai Chinese medicine .1992; 4:21-23; Chen Yanping, Wang Yiqin, Chen Weibin, etc. the hot agent of compound recipe fiber crops sucks the observation of curative effect and the experimentation of treatment infantile asthma. the journal .2002 of Shanghai Univ. of Traditional Chinese Medicine; 16 (2): 42-45). and the clinical research that also has the scholar to carry out Chinese medicine to substitute hormone therapy asthma (Sun Zhijia. the utilization Chinese medicine substitutes the clinical research of hormone therapy asthma. Chinese practical Chinese and western medicine magazine .2005,18 (1): 70). the Chinese medicine decoction has the inadequate shortcoming of extraction in decoction process, many liposoluble constituents are difficult to be suggested, though some contains under the Chinese medicine back of volatile oil component, also loss to some extent in high temperature decocts unavoidably, and medicinal residues also can adsorb many effective ingredient usually. the form improvement of Chinese medicine is very important and necessary. suppress asthma attack fast but still lack in the market, the Chinese medicine preparation of control recurrence. the Chinese patent medicine of relievining asthma is very many, but the dosage form imperfection, curative effect is undesirable.
Chinese patent CN1626162A discloses a kind of atomizing liquid (Rhizoma Belamcandae: Herba Ephedrae: the Rhizoma Pinelliae: Ramulus Cinnamomi: Semen Armeniacae Amarum: Radix Platycodonis: the Radix Astragali: Fructus Perillae=3: 2: 3: 2: 3: 3: 5: the 2) method of Zhi Zuoing of relievining asthma on 06 15th, 2005.The patient who is used for the treatment of acute bronchial asthma and prevention outbreak.The data support of no clinical efficacy.
Chinese patent CN1557435A disclosed capsule of a kind of inflammation-diminishing and cough-controlling and preparation method thereof (Folium Elaeagni 200g, Radix Platycodonis 150g, Radix Pseudostellariae 200g, Radix Stemonae 100g, Pericarpium Papaveris 12.5g, Herba Ephedrae 25g, Fructus Viticis Negundo 125g, Radix Adenophorae 37.5g, Herba Andrographis 125g) on the 29th in December in 2004.This medicine is used for the cough of acute upper respiratory tract infection and the cough and asthma patient of acute/chronic bronchitis, but effect is mainly used in acute attack than limitation.Be used for chronic bronchitis through clinical observation and send out author's totally 96 examples winter, its effective percentage is 86%.
Chinese patent CN1106273A discloses the syndromic Chinese medicine preparation of a kind of treatment upper respiratory tract infection (Radix Scutellariae 10-30g, process Semen Armeniacae Amarum 6-20g, Semen Lepidii (Semen Descurainiae) 10-30g, Radix Platycodonis 10-30g, Gypsum Fibrosum 15-50g, Radix Glycyrrhizae 6-20g) in 08 month 09 day nineteen ninety-five.Be mainly used in treatment diseases caused by exogenous pathogenic factor, cough, laryngopharynx swelling and pain and asthma.100 parts of cases of statistics treatment, healing person's 92 examples, significant curative effect person 6 examples, no significant curative effect person 2 examples, total effective rate 98%.But its effect is limitation, is mainly used in upper respiratory tract infection.
Do not find and the same or analogous pharmaceutical composition of the present invention in the prior art.The medicine of at present numerous treatment cough with asthma, as JIZHI TANGJIANG, cough-relieving breathe heavily, MILIAN CHUANBEI PIPA GAO etc.Curative effect is not good enough, can not effectively control the outbreak of asthma.
Summary of the invention
At the above-mentioned deficiency of prior art, this bright technical problem that will solve be to propose a kind of pharmaceutical composition for the treatment of chronic bronchitis, bronchial asthma and emphysema etc.This pharmaceutical composition has no side effect substantially, but life-time service, and have treatment and preventive effect simultaneously.
In order to solve the problems of the technologies described above, the pharmaceutical composition of treatment bronchial asthma, chronic bronchitis and emphysema that the present invention proposes is the medicament of being made by following raw material medicaments:
Herba Ephedrae (processed) 2-8 part; Radix Scutellariae 6-20 part; Scorpio 2-6 part;
Semen Lepidii (Semen Descurainiae) 4-15 part; Fructus Nandinae Domesticae 6-20 part; Folium Elaeagni 4-20 part.
As optimal technical scheme of the present invention, further include in the crude drug of aforementioned pharmaceutical compositions and be selected from Fructus Xanthii, Flos Magnoliae and the Flos Mume one or more.
The crude drug weight proportion of aforementioned pharmaceutical compositions is most preferably: 6 parts of Herba Ephedrae (processed), 15 parts of Radix Scutellariaes, 4 parts of Scorpio, 10 parts of Semen Lepidii (Semen Descurainiae)s, 10 parts of Fructus Nandinae Domesticaes, 10 parts of Folium Elaeagnis.
The above-mentioned medicament of the present invention is a said dosage form on any pharmaceutics, preferred propellant, tablet, pill, capsule or tincture.
Herba Ephedrae is Ephedraceae plant plait Herba Ephedrae Ephedra sinica Stapf., the dry herb stem of epheday intermedia E intermedia Schrenket C.A.Mey. or ephedra equisetina E equisetina Bge.. main product is in Hebei, Shanxi, the Inner Mongol, ground such as Gansu. the present invention is raw materials used for producing in Gansu. the nature and flavor suffering of Herba Ephedrae, little hardship, temperature. return lung, urinary bladder channel. relieving the exterior syndrome by diaphoresis is arranged, depressed lung-energy dispersing, the effect of inducing diuresis to remove edema. Shennong's Herbal is said: Herba Ephedrae " is ended cough with dyspnea, removes cold and heat ". say Herba Ephedrae " controlling asthma due to stagnation of phlegm pants " in the essentials of Matea Medica. Herba Ephedrae mainly contains multiple alkaloid and a small amount of volatile oil. and main effective ingredient is a sanedrine in the alkaloid, account for the 80%-85% of total alkaloids; Secondly be pseudoephedrine. contain the I-alpha-terpineol in the volatile oil, still contain tannin etc. in addition. mainly contain diaphoresis, relieving asthma, diuresis, antiinflammatory, antiallergic, antitussive, eliminate the phlegm, effect such as analgesic, antibiotic, antiviral. other also have stimulating central nervous system system, heart tonifying, rising blood pressure, suppress effect such as myenteron contraction. pharmacological research shows: ephedrine has tangible relexation to bronchial smooth muscle, and its volatile oil has very strong inhibitory action to influenza virus.
Radix Scutellariae is the dry root of labiate Radix Scutellariae Scutellaria baicalcnsis Georgi.Main product in Hebei, ground such as Shanxi, the Inner Mongol, Henan and Shaanxi.The present invention is raw materials used for producing in Hebei.The nature and flavor bitter cold of Radix Scutellariae is returned lung, gallbladder, spleen, large intestine, small intestine meridian, and the effect of heat clearing and damp drying, eliminating fire and detoxication, arresting bleeding and miscarriage prevention is arranged, kind lung heat clearing, large intestine and gallbladder fire.Main chemical compositions is a flavone compound, and kind surplus definite structure has 30 is the highest with content of baicalin, still contains compositions such as aminoacid, volatile oil, sugar, sterols in addition.That Radix Scutellariae mainly contains is antibiotic, antiallergic action, blood pressure lowering, diuresis, antiinflammatory, pharmacological action such as analgesic.
Scorpio is the dry body of Buthidae animal Scorpio Buthus martensii kirsch.Catch at the beginning of spring end to autumn, remove silt, put boiling water or the saline that boils in, boil to whole body stiffly, pull out, put the ventilation, dry in the shade.Nature and flavor suffering, flat.Return Liver Channel.Effect with endogenous wind stopping relieving convulsion, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Chemical constituent has fatty acid, inorganic elements and scorpion venom.
Fructus Nandinae Domesticae is the fruit of Berberidaceae plant Fructus Nandinae Domesticae Nandina Domestica Thunb.Nature and flavor acid, sweet, flat.Astringe the lung, cough-relieving, liver heat removing, function makes eye bright.Fructus Nandinae Domesticae contains that alkaloid is mainly O-methyl domesticine, other also have protopine, isocorydine, nandinine, 1-hydroxy-2-methoxy-9,10-methylenedioxyaporphine. etc.Contain hoof stricture of vagina India-3-primaverose, callistephin in addition.Seed contains unsaturated fatty acid (being mainly linoleic acid), and contains protopine.That pharmacological action has is antibiotic, suppress heart, cholesterol reducing, inhibition respiratory center, paralysis striped muscle etc.
Folium Elaeagni is the dried leaves of Elaeangnaceae plant Fructus Elaeagni Elaeagnus pungens Thunb.All there is distribution in most of area, the whole nation.The acid of Folium Elaeagni nature and flavor, little hardship, flat are returned lung meridian.Have that astringing lung-QI and relieving cough is relievingd asthma, stopped blooding, the detumescence function, often be cough and asthma, the hemoptysis etc. controlled among the people, " control dyspnea and cough due to adverse raising of QI " as " Huatuo's Zhongzang classic ".Folium Elaeagni contains alkaloid, flavonoid, Coumarins, triterpenes and organic acid.Also contain cupreol, ursolic acid, oleanolic acid, cupreol-β-D-glucopyanoside.Pharmacological action have relieving asthma, antibiotic, antivirus action.
Semen Lepidii (Semen Descurainiae) is the dry mature seed of crucifer Lepidium sativum L. Lepidium apetalum Willd. or descurainia sophia (l.) webb ex prantl Descurainia Sophia (L.) Webb ex prantl..The former practises title " lepidii,semen ", and the latter practises title " Semen Descurainiae ".Nature and flavor suffering, hardship, Great Cold.Return lung, urinary bladder channel.Effect with eliminating pathogen from the lung for relieving asthma, line water detumescence is that the treatment lung qi is stopped up the good merchantable brand that excess-dyspnea is coughed.Be mainly used in accumulation and obstruction of sputum, cough with asthma and can not put down for sleeping in, edema, hydrothorax, breast abdomen hydrops, dysuria etc.Pharmacological evaluation confirms that Semen Lepidii (Semen Descurainiae) stimulates the mouse cough reaction that causes that obvious antitussive action is arranged to the ammonia mist, and it is phenol red to strengthen the drainage of mice trachea, and bronchial smooth muscle is had spasmolysis.The effective ingredient of its cough-relieving is a sinigrin.Benzyl mustard oil in the Semen Lepidii (Semen Descurainiae) has broad-spectrum antibacterial action.
" card control converge mend bronchial wheezing " said: " and heavy breathing is phlegm dyspnea Chang Fazhe, because of in the gas that is jammed is arranged, the sense when non-is arranged outward, diaphragm has the solid expectorant of glue, the three is harmonious, and closes according to air flue, fights with soundly, is bronchial wheezing." Ming Dynasty's Li Shizhen (1518-1593 A.D.) to Semen Lepidii (Semen Descurainiae) eliminating the pathogens from the lung eliminate the phlegm very and to praise highly, its cloud: " aqueous vapor Ben Yu is completely anxious in the lung, and non-this can not remove." think that as long as there is phlegm retention water wet in the lung be available and rush down it.Above-mentioned composition epheday intermedia of the present invention and Semen Lepidii (Semen Descurainiae) dispersing and descending lung-QI, the clearing away phlegm of relievining asthma, Radix Scutellariae has the merit of clearing and antitussive concurrently, and full side has the effect of eliminating pathogen from the lung for relieving asthma, removing heat-phlegm, lung qi dispersing cough-relieving.
Preparation of drug combination process of the present invention there is no special requirement.To be described in detail the preparation method of various dosage forms in the present invention's specific embodiment subsequently.
The following experiment of the present invention shows that aforementioned pharmaceutical compositions can effectively treat bronchial asthma, chronic bronchitis, emphysema etc.It has no side effect substantially, but life-time service.
In recent years discover lung blood vessel, bronchial smooth muscle shrink, may with TXA
2And PGI
2Dysequilibrium is relevant, and blood plasma TXB
2And 6-Keto-PGF
1α is respectively TXA
2And PGI
2Metabolite.Bronchial asthma patient when acute attack, TXB in its blood plasma
2Level obviously raises, 6-Keto-PGF
1Alpha levels obviously reduces, TXB
2/ 6-Keto-PGF
1α ratio obviously raises.Aforementioned pharmaceutical compositions of the present invention can be by reducing TXB
2/ 6-Keto-PGF
1The ratio of α and bring into play the diastole bronchial smooth muscle and suppress the effect of asthma inflammatory reaction.
The eosinophilic granulocyte is the key cells that causes tardy phase asthma reaction and airway hyperreactivity, is the main effects cell in the bronchial asthma pathogenesis, plays an important role in the adjusting of mediation airway inflammation participation bronchial asthma morbidity.Eosinophilic granulocyte's number significantly increases in the zoopery prompting asthmatic guinea pigs model group bronchoalveolar lavage fluid, and aforementioned pharmaceutical compositions of the present invention can effectively reduce eosinophilic granulocyte's number in the bronchoalveolar lavage fluid.
MEFV, FEV are assessment airway obstruction sensitive indicators, and all there is airway obstruction in various degree in bronchial asthma patient.After aforementioned pharmaceutical compositions of the present invention treatment, the function of asthmatic patient big airways and little air flue all is significantly improved, and with the alleviation of clinical symptoms, sign mutually-cause.Zoopery confirms that pharmaceutical composition of the present invention really can reduce airway resistance, and improves the compliance of lung.
The using method of pharmaceutical composition of the present invention can adopt multiple administration form such as atomizing sucks, applies ointment or plaster, acupuncture point iontophoresis, all obtains clinical effectiveness preferably.Pharmacodynamics and clinical observation on the therapeutic effect result are as follows:
1. pharmaceutical composition atomizing of the present invention sucks asthmatic model guinea pig plasma TXB
2, 6-Keto-PGF
1The influence of alpha content.
The preparation that contains above pharmaceutical composition: the Shanghai Univ. of Traditional Chinese Medicine institute of Chinese materia medica provides, and is made up of Herba Ephedrae, Herba Asari, Radix Scutellariae, Radix Glycyrrhizae etc., and every 10ml contains crude drug 10g.80 of pure white Cavia porcelluss (providing by Shanghai Univ. of Traditional Chinese Medicine's Experimental Animal Center) are provided, regular grade, male and female half and half, body weight is at 150-250g.Be divided into totally four groups of normal group, model group, Chinese herbal aerosol group, Western medicine atomizing group, 20 every group.Except that normal group, each organizes lumbar injection 1% egg protein 0.5ml sensitization.2 week backs suck to draw with the atomizing of 2% egg protein liquid breathes heavily, the next day 1 time, finish to experiment, draw and begin medication after breathing heavily.The Chinese herbal aerosol group sucks 10min with above compound preparation 1ml atomizing, the next day once; Western medicine atomizing group atomizing sucks 15% and breathes heavily happy peaceful 0.15ml, the next day once, each 1min all treated for 3 weeks.Measure guinea pig plasma TXB
2, 6-Keto-PGF
1Alpha content, as shown in table 1, after sucking, pharmaceutical composition atomizing of the present invention can significantly reduce 6-Keto-PGF in the blood plasma
1The level of α.
Table 1
| Group | TXB 2(ng/L) | 6-Keto-PGF 1α(pg/ml) |
| Normal group | 62.12±6.36 | 195.77±6.17 * |
| Model group | 63.73±6.21 | 175.16±14.01 |
| The Chinese herbal aerosol group | 63.08±10.49 | 184.06±14.05 * |
| Western medicine atomizing group | 73.67±10.85 | 185.54±8.16 * |
Annotate: compare with model group,
*P＜0.05; Compare #P＜0.05 with Western medicine atomizing group
2. the observation of curative effect of pharmaceutical composition point application iontophoresis infantile asthma of the present invention.
The preparation that contains above pharmaceutical composition:, select percolation for use, and formulate certain qualitative and semiquantitative charge index by pharmacopeia method tincture preparation technology.Select infant 71 examples of asthma in acute attack.Be divided into treatment group, oral matched group and the matched group of applying ointment or plaster at random.The treatment group is soaked into gauze with above preparation, is applied on Gaomang point and the both sides FEIYU acupoint, puts pulsed ion introducing apparatus battery lead plate then on above-mentioned acupuncture point, perfectly straight stream pulse current 4mA, and each 30min, every day 1 time, 7 days is 1 course of treatment.Oral matched group takes juice with the former dosage water of the former side of XIAOQINGLONG TANG, and it is oral to contain crude drug 1g/ml.The matched group of applying ointment or plaster paddy Fructus Hordei Germinatus tincture, method is with the treatment group.Observe infant breathing, heart rate, cough with asthma, cough up phlegm, many index such as pulmonary's wheezing sound and detect pulmonary function.
Treatment group total effective rate is 91.25%, and pulmonary function is significantly improved.
3. the observation of curative effect of drug composition oral treatment infantile asthma of the present invention.
In late May, 2005 is observed asthma infant 120 examples to early December the same period at Longhua Hospital affiliated Shanghai University Of Chinese Traditional Medicine and the 9th the People's Hospital, Shanghai City.In age 5-14 year, 60 examples are organized in treatment, I level 43 people, II level 7 people, III level 10 people: matched group 60 examples, I level 48 people, II level 5 people, III level 7 people.Asthma diagnosis and degree of being in a bad way classification all meet " child's prevention and control of bronchial asthma routine " standard.Two groups of patient clinical datas compare, and difference does not have significance (P＞005), has comparability.Diagnostic criteria is " the child's prevention and control of bronchial asthma routine " that department of pediatrics branch of Chinese Medical Association pneumatology group is worked out.Therapeutic scheme is worked out by Chinese and western medicine asthma expert respectively, and treatment group and matched group adopt therapy of combining Chinese and Western medicine scheme and simple western medical treatment scheme respectively.Curative effect judging standard is with reference to Chinese Medical Association's respiratory disease credit meeting " prevention and control of bronchial asthma guide "
Therapeutic outcome shows: clinic control 48 examples (80%), produce effects 8 examples (13.3%), 4 examples that take a turn for the better (6.7%), total effective rate 100%.Matched group: clinic control 40 examples (66.7%), produce effects 6 examples (10%), 9 examples that take a turn for the better (15%), invalid 5 (8.3%) examples, total effective rate 91.7%.Two groups relatively: treatment group cure rate, total effective rate all are higher than matched group.60 routine infants are during therapy of combining Chinese and Western medicine scheme treatment in this experiment, with the sings and symptoms of simple WM therapy group infant be improved significantly, attack times obviously reduces, and is enhanced to the resistance of flu and to the adaptability of climate change.
The specific embodiment
Below in conjunction with embodiment the present invention is further described.
Embodiment 1
Get Herba Ephedrae (processed) 100g, Radix Scutellariae 300g, Scorpio 100g, Semen Lepidii (Semen Descurainiae) 200g, Fructus Nandinae Domesticae 300g, Folium Elaeagni 200g.The water logging that adds 8 times of medical material weight was steeped 60 minutes, decocted, and back 1/2 hour after-filtration taking liquid boils, the decocting that medicinal residues add 8 times of medical material weight boils 1h after-filtration taking liquid, merges 2 times filtrate, is condensed into 3200ml, add dehydrated alcohol to containing alcohol amount 60%, 12h is left standstill in cold preservation, get supernatant after, sucking filtration, merging filtrate reclaims ethanol, fine straining, be settled to distilled water and contain crude drug 0.5g/ml, promptly get medicinal liquid.Suck with the ultrasound atomizer atomizing, each 15min, seven days is a course of treatment.
Embodiment 2
Get Herba Ephedrae (processed) 160g, Radix Scutellariae 400g, Scorpio 120g, Semen Lepidii (Semen Descurainiae) 300g, Fructus Nandinae Domesticae 400g, Folium Elaeagni 400g.Above pulverizing medicinal materials is become coarse granule (200 order), with 60% alcohol dipping 10h.Use the percolator percolation, percolation speed be 3-5 drip/minute.Collect with big conical flask, adjusting determining alcohol at last is 52%.Promptly get tincture.With 6 layers of big or small battery lead plate that gets of gauze parcel 8 * 12cm, soak into the tincture medicinal liquid, pass to dc pulse current, positive pole places region below the heart, FEIYU acupoint, and negative pole places hundred labor caves.30 minutes time, every day 1 time, 5 times is a course of treatment.
Embodiment 3
Get Herba Ephedrae (processed) 120g, Radix Scutellariae 300g, Scorpio 80g, Semen Lepidii (Semen Descurainiae) 200g, Fructus Nandinae Domesticae 200g, Folium Elaeagni 200g. decoct with water 2 times, 2 hours for the first time, 1 hour for the second time, collecting decoction, filter, be concentrated into thick paste. above-mentioned thick paste is carried out spray drying, add 10% acrylic resin I number 80% alcoholic solution 60ml, stirred 9 minutes, add the 2.5g magnesium stearate, make granule, in 60 ℃ of oven dry, incapsulate, capsule.
Embodiment 4
Get Herba Ephedrae (processed) 180g, Radix Scutellariae 450g, Scorpio 120g, Semen Lepidii (Semen Descurainiae) 300g, Fructus Nandinae Domesticae 300g, Folium Elaeagni 300g.Decoct with water 2 times, 2 hours for the first time, 1 hour for the second time, collecting decoction, be evaporated to density and be 1.05-1.15 (90-95 ℃) heat and survey, put coldly, add ethanol, placed 12 hours to containing alcohol amount 75%, filter, filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and is concentrated to the thick paste (about 400ml) that density is 1.17-1.30 (90-95 ℃ of heat is surveyed), add beta-schardinger dextrin-12.5g, starch 20g, magnesium stearate 0.5g, mixing is made granule, drying, tabletting, sugar coating promptly gets tablet.
Embodiment 5
Get Herba Ephedrae (processed) 240g, Radix Scutellariae 600g, Scorpio 160g, Semen Lepidii (Semen Descurainiae) 400g, Fructus Nandinae Domesticae 400g, Folium Elaeagni 400g, Fructus Xanthii 400g.Decoct with water 2 times, 2 hours for the first time, 1 hour for the second time, collecting decoction filters, and filtrate is condensed into the concentrated solution that relative density is 1.08-1.10, spray drying is collected dried cream powder, with the appropriate amount of auxiliary materials mixing, make ball, drying in addition with a little anhydrous alcohol solution of Mentholum, sprays in the ball, coating promptly gets pill.
Embodiment 6
Get Herba Ephedrae (processed) 240g, Radix Scutellariae 600g, Scorpio 160g, Semen Lepidii (Semen Descurainiae) 400g, Fructus Nandinae Domesticae 400g, Folium Elaeagni 400g, Fructus Xanthii 400g, Flos Magnoliae 400g, Flos Mume 400g.Decoct with water 2 times, 2 hours for the first time, 1 hour for the second time, collecting decoction filters, and filtrate is condensed into the concentrated solution that relative density is 1.08-1.10, spray drying is collected dried cream powder, with the appropriate amount of auxiliary materials mixing, make ball, drying in addition with a little anhydrous alcohol solution of Mentholum, sprays in the ball, coating promptly gets pill.
Claims (4)
1. pharmaceutical composition for the treatment of bronchial asthma, chronic bronchitis and emphysema is characterized in that it is the medicament of being made by following materials of weight proportions medicine:
Herba Ephedrae (processed) 2-8 part;
Radix Scutellariae 6-20 part;
Scorpio 2-6 part;
Semen Lepidii (Semen Descurainiae) 4-15 part;
Fructus Nandinae Domesticae 6-20 part;
Folium Elaeagni 4-20 part.
2. the pharmaceutical composition of treatment bronchial asthma according to claim 1, chronic bronchitis and emphysema is characterized in that it is the medicament that is prepared from by following raw materials by weight proportions:
6 parts of Herba Ephedrae (processed); 15 parts of Radix Scutellariaes; 4 parts of Scorpio;
10 parts of Semen Lepidii (Semen Descurainiae)s; 10 parts of Fructus Nandinae Domesticaes; 10 parts of Folium Elaeagnis.
3. according to the pharmaceutical composition of any one described treatment bronchial asthma, chronic bronchitis and emphysema in claim 1 or 2, it is characterized in that described medicament is a said dosage form on any pharmaceutics.
4. the pharmaceutical composition of treatment bronchial asthma according to claim 3, chronic bronchitis, emphysema is characterized in that described medicament is propellant, tablet, pill, capsule or tincture.
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| CN103251863B (en) * | 2013-05-12 | 2014-09-24 | 张磊 | Chinese medicinal decoction for treating stagnant pathogen of Shaoyang type pleural effusion |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634340A (en) * | 2004-11-16 | 2005-07-06 | 南京开来医药科技开发有限责任公司 | Medicinal composition for preventing and treating children respiratory system diseases and preparation method thereof |
| CN1704100A (en) * | 2004-05-27 | 2005-12-07 | 江西省药物研究所 | Chinese compound medicinal preparation for treating asthma and method for preparing the same |
-
2006
- 2006-01-23 CN CN200610023544A patent/CN101007058B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1704100A (en) * | 2004-05-27 | 2005-12-07 | 江西省药物研究所 | Chinese compound medicinal preparation for treating asthma and method for preparing the same |
| CN1634340A (en) * | 2004-11-16 | 2005-07-06 | 南京开来医药科技开发有限责任公司 | Medicinal composition for preventing and treating children respiratory system diseases and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 朱慧华等.辛苍汤对小儿支气管哮喘缓解期慢性气道炎症的治疗作用.中西医结合学报3 1.2005,3(1),23-27. |
| 朱慧华等.辛苍汤对小儿支气管哮喘缓解期慢性气道炎症的治疗作用.中西医结合学报3 1.2005,3(1),23-27. * |
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| Publication number | Publication date |
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| CN101007058A (en) | 2007-08-01 |
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