CN102266434B - Chinese medicinal composition for resisting tumor metastasis and preparation method thereof - Google Patents
Chinese medicinal composition for resisting tumor metastasis and preparation method thereof Download PDFInfo
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- CN102266434B CN102266434B CN 201110223422 CN201110223422A CN102266434B CN 102266434 B CN102266434 B CN 102266434B CN 201110223422 CN201110223422 CN 201110223422 CN 201110223422 A CN201110223422 A CN 201110223422A CN 102266434 B CN102266434 B CN 102266434B
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Abstract
The invention discloses a Chinese medicinal composition for resisting tumor metastasis and a preparation method thereof. The Chinese medicinal composition for resisting tumor metastasis consists of antidesma bunius, tungoiltree juvenile leaf and winter daphne root. In combination with the result of the conventional Chinese medicinal compound efficacious material basis research and on the basis of a Chinese medicinal compound effective position group, the Chinese medicinal composition has a tumor metastasis resisting effect. The Chinese medicinal composition is suitable for a large quantity of patients, can be taken for a long time after surgeries of stomach cancer, lung cancer and the like or radiation treatment and chemo-treatment, has low cost and curative effect advantage and is hopeful to achieve a good economic benefit; and the medical expenses can be saved, and the national health and medicine investment can be reduced directly.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to Chinese medicine composition of a kind of anti metastasis and preparation method thereof.
Background technology
Tumor is one of main illness of current harm humans health.Invasion and metastasis of tumor is a kind of biological behaviour and the most essential feature that malignant tumor is the most general, and being also affects tumor patient existence and prognosis key factor.
Chinese invention patent publication number CN1990031A discloses " natural drug of prophylaxis of tumours ", adopts Rhizoma Alismatis, Semen Coicis, Rabdosia rubescens, Radix Scutellariae, Ganoderma, Radix Glycyrrhizae to form; This natural drug is to form with Chinese medicine replenishing QI to invigorate the spleen Chinese crude drug, embodiment be made as the master for improving the immunity therapeutic apparatus.
Chinese invention patent publication number CN101067006A once disclosed " low molecule Agaricus Blazei Murrill polysaccharide and preparation method and the application in medicine for treating tumor metastasis ", adopting the Agaricus blazei Murrill sporophore is that raw material extracts preparation and take polysaccharide component as the effect position, embodiment be made as the master for improving the immunity therapeutic apparatus.
Summary of the invention
The object of the invention is to according to the deficiencies in the prior art, a kind of Chinese medicine composition of new anti metastasis is provided.
Another purpose of the present invention is to provide the preparation method of the Chinese medicine composition of above-mentioned anti metastasis.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
A kind of Chinese medicine composition of anti metastasis, be comprised of the following component according to the mass fraction meter: Radix seu Folium Antidesmae bunii 10 ~ 30, Folium Aleuritis Fordii 10 ~ 30, Radix daphnes odorae 10 ~ 30.
The preparation method of the Chinese medicine composition of the above-mentioned anti metastasis of the present invention comprises the steps:
(1) by weight ratio, take each crude drug Radix seu Folium Antidesmae bunii, Folium Aleuritis Fordii and Radix daphnes odorae standby;
(2) add Radix seu Folium Antidesmae bunii, Folium Aleuritis Fordii and 8 ~ 10 times of water gagings of Radix daphnes odorae gross weight and soak 2`3 hour, heating decocts, and decoction liquor is filtered; Medicinal residues add 8 ~ 10 times of water gaging heating again, and decoction liquor is filtered, and filtrate merges, and obtains supernatant;
(3) supernatant concentration to relative density is 1.05 ~ 1.06 o'clock, advances spray dryer, and inlet temperature is controlled 140 ~ 160 ℃, 100 ~ 110 ℃ of leaving air temps, and charging rate is 3 ~ 6 ml/ minute, obtains the Chinese medicine composition that spray drying powder is anti metastasis.
The Chinese medicine composition of anti metastasis of the present invention can add the conventional formulation of this area, according to conventional method, prepares oral formulations.
Compared with prior art, the present invention has following beneficial effect:
Chinese medicine composition of the present invention comprises: Radix seu Folium Antidesmae bunii acid, and temperature, have the promoting flow of QI and blood effect; Folium Aleuritis Fordii has the subduing swelling and detoxicating effect; Radix daphnes odorae is sweet, salty, is the Isolated From Thymelaeaceae Species winter daphne
'sroot
orroot bark
,there is removing toxic substances, the promoting blood circulation and stopping pain effect.Above-mentioned three herbal medicines form, and embody detoxicating and resolving stagnation of pathogens, the blood-activating and qi-promoting effect, and for " stasis of blood, the poison " pathological state in tumor patient later stage, the rule for the treatment of compatibility Chinese medicine composition of the present invention with detoxicating and resolving stagnation of pathogens, blood circulation promoting and blood stasis dispelling, play inhibiting effect on tumor metastasis.At present openly the Chinese medicine patent is main for neoplasm metastasis patient " void ", take the rule for the treatment of such as QI invigorating as main.
The specific embodiment
Further explain the present invention below in conjunction with embodiment, but embodiment does not limit in any form to the present invention.
the Chinese medicine composition that embodiment 1 has inhibiting effect on tumor metastasis prepares water decoction
1. the raw material medicines in portions by weight proportioning is as follows: Radix seu Folium Antidesmae bunii 100 grams, Folium Aleuritis Fordii 100 grams, Radix daphnes odorae 100 grams;
2. preparation method is as follows:
(1) get crude drug by above-mentioned weight portion proportioning;
(2) add Radix seu Folium Antidesmae bunii, Folium Aleuritis Fordii and 8 times of water gagings of Radix daphnes odorae gross weight to soak 2 hours, heating decocts, the rear filtration of boiling; Medicinal residues add 8 times of water gagings again and are heated to boil, the rear filtration of boiling, and filtrate merges, and is water decoction.
embodiment 2
1. the raw material medicines in portions by weight proportioning is as follows
:radix seu Folium Antidesmae bunii 300, Folium Aleuritis Fordii 300, Radix daphnes odorae 300.
2. preparation method is as follows:
(1) get crude drug by above-mentioned weight portion proportioning;
(2) add Radix seu Folium Antidesmae bunii, Folium Aleuritis Fordii, 10 times of water gagings of Radix daphnes odorae gross weight to soak 3 hours, heating decocts, the rear filtration of boiling; Medicinal residues add 10 times of water gagings again and are heated to boil, the rear filtration of boiling, and filtrate merges, and obtains supernatant;
(3) supernatant concentration to relative density is 1.05 o'clock, advances spray dryer, and inlet temperature is controlled 140 ℃, 100 ℃ of leaving air temps, and charging rate is 3ml/ minute, obtains spray drying powder 180 grams.
By spray drying powder, technique can be made oral formulations routinely, as oral liquid, capsule, tablet or electuary etc.
embodiment 3
1. the raw material medicines in portions by weight proportioning is as follows
:radix seu Folium Antidesmae bunii 150, Folium Aleuritis Fordii 150, Radix daphnes odorae 150.
2. preparation method is as follows:
(1) get crude drug by above-mentioned weight portion proportioning;
(2) add Radix seu Folium Antidesmae bunii, Folium Aleuritis Fordii, 10 times of water gagings of Radix daphnes odorae gross weight to soak 3 hours, heating decocts, the rear filtration of boiling; Medicinal residues add 10 times of water gagings again and are heated to boil, the rear filtration of boiling, and filtrate merges, and obtains supernatant;
(3) supernatant concentration to relative density is 1.05 o'clock, advances spray dryer, and inlet temperature is controlled 140 ℃, 100 ℃ of leaving air temps, and charging rate is 3ml/ minute, obtains spray drying powder 35 grams.
By spray drying powder, technique can be made oral formulations routinely, as oral liquid, capsule, tablet or electuary etc.
the impact of embodiment 4 Chinese medicine composition of the present invention on FC gastric cancer mouse tumor metastasis inhibition rate
The present embodiment Chinese medicine composition used is the Chinese medicine composition that embodiment 3 makes.Inbred line 615 mices, male, body weight 18 ~ 22g, 40.Get front squamous cell carcinoma of stomach (FC) tissue of the portability of 8 ~ 10d after transplanting, be prepared into 1 * 10
10the cell suspension of/L, in the right axil subcutaneous injection of mice cell suspension 0.2ml/ only.Be divided at random 4 groups after the strain of mouse inoculation tumor, 10 every group.Does grouping comprise that (this matched group is positive control or negative control to matched group? if negative control, also need to provide again the correction data of positive control), high dose group (20g/kg), middle dosage group (10g/kg), low dose group (5g/kg).Every treated animal is second day difference gastric infusion after connecing tumor, and be administered once every day, and continuous 3 weeks, the matched group gavage waited and measures normal saline.Anatomy experiment mice after experiment finishes, take out lungs, the total metastasis number of counting pulmonary.Metastasis is ecru, edge polishing, similar round tuberosity.Metastasis inhibition rate=(blank group metastasis number-administration group metastasis number)/blank group metastasis number * 100%.The results are shown in following table.
Claims (2)
1. the Chinese medicine composition of an anti metastasis, is characterized in that by making according to the component of mass fraction meter as follows: Radix seu Folium Antidesmae bunii 10 ~ 30, Folium Aleuritis Fordii 10 ~ 30, Radix daphnes odorae 10 ~ 30.
2. the preparation method of the Chinese medicine composition of the described anti metastasis of claim 1, is characterized in that comprising the steps:
(1) by weight ratio, take each crude drug Radix seu Folium Antidesmae bunii, Folium Aleuritis Fordii and Radix daphnes odorae standby;
(2) add Radix seu Folium Antidesmae bunii, Folium Aleuritis Fordii and 8 ~ 10 times of water gagings of Radix daphnes odorae gross weight and soak 2 hours or 3 hours, heating decocts, and decoction liquor is filtered; Medicinal residues add 8 ~ 10 times of water gaging heating again, and decoction liquor is filtered, and filtrate merges, and obtains supernatant;
(3) supernatant concentration to relative density is 1.05 ~ 1.06 o'clock, advances spray dryer, and inlet temperature is controlled 140 ~ 160 ℃, 100 ~ 110 ℃ of leaving air temps, and charging rate is 3 ~ 6 ml/ minute, obtains the Chinese medicine composition that spray drying powder is anti metastasis.
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| CN 201110223422 CN102266434B (en) | 2011-08-05 | 2011-08-05 | Chinese medicinal composition for resisting tumor metastasis and preparation method thereof |
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| CN 201110223422 CN102266434B (en) | 2011-08-05 | 2011-08-05 | Chinese medicinal composition for resisting tumor metastasis and preparation method thereof |
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| CN102266434B true CN102266434B (en) | 2013-04-10 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110559334A (en) * | 2019-10-23 | 2019-12-13 | 中国热带农业科学院海口实验站 | May tea and fruit extract and application thereof in preventing and treating breast cancer |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102940761B (en) * | 2012-11-08 | 2014-01-08 | 梁立周 | Traditional Chinese medicine for treating graphospasm |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879842A (en) * | 2006-05-17 | 2006-12-20 | 郭富红 | A Chinese medicine for treating cancer |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1879842A (en) * | 2006-05-17 | 2006-12-20 | 郭富红 | A Chinese medicine for treating cancer |
Non-Patent Citations (4)
| Title |
|---|
| 张玲玲等.油桐资源价值及其开发利用前景.《经济林研究》.2011,第29卷(第2期),第130-136页. |
| 张薇等.瑞香属植物化学成分及其药理与临床作用的研究.《药学进展》.2005,第29卷(第1期),第22-27页. |
| 油桐资源价值及其开发利用前景;张玲玲等;《经济林研究》;20110630;第29卷(第2期);第130-136页 * |
| 瑞香属植物化学成分及其药理与临床作用的研究;张薇等;《药学进展》;20050131;第29卷(第1期);第22-27页 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110559334A (en) * | 2019-10-23 | 2019-12-13 | 中国热带农业科学院海口实验站 | May tea and fruit extract and application thereof in preventing and treating breast cancer |
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