CN102526431B - Traditional Chinese medicine preparation for treating gastric cancer and preparation method - Google Patents
Traditional Chinese medicine preparation for treating gastric cancer and preparation method Download PDFInfo
- Publication number
- CN102526431B CN102526431B CN2012100866541A CN201210086654A CN102526431B CN 102526431 B CN102526431 B CN 102526431B CN 2012100866541 A CN2012100866541 A CN 2012100866541A CN 201210086654 A CN201210086654 A CN 201210086654A CN 102526431 B CN102526431 B CN 102526431B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- radix
- achyranthis bidentatae
- portions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 40
- 208000005718 Stomach Neoplasms Diseases 0.000 title claims abstract description 21
- 206010017758 gastric cancer Diseases 0.000 title claims abstract description 21
- 201000011549 stomach cancer Diseases 0.000 title claims abstract description 21
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 241000237903 Hirudo Species 0.000 claims description 16
- 241000283956 Manis Species 0.000 claims description 16
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 16
- 241000180649 Panax notoginseng Species 0.000 claims description 16
- 238000012545 processing Methods 0.000 claims description 13
- 235000005903 Dioscorea Nutrition 0.000 claims description 12
- 241000234273 Dioscorea Species 0.000 claims description 12
- 235000000504 Dioscorea villosa Nutrition 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 241000545442 Radix Species 0.000 claims description 12
- 235000004879 dioscorea Nutrition 0.000 claims description 12
- 239000004615 ingredient Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 238000005325 percolation Methods 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- 230000003179 granulation Effects 0.000 claims description 4
- 238000005469 granulation Methods 0.000 claims description 4
- 230000001476 alcoholic effect Effects 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 239000000314 lubricant Substances 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 abstract description 25
- 201000011510 cancer Diseases 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 10
- 230000036039 immunity Effects 0.000 abstract description 4
- 230000001717 pathogenic effect Effects 0.000 abstract description 3
- 238000011160 research Methods 0.000 abstract description 3
- 230000004087 circulation Effects 0.000 abstract description 2
- 230000004060 metabolic process Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 241000427159 Achyranthes Species 0.000 abstract 1
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 240000008537 Burchellia bubalina Species 0.000 abstract 1
- 235000004415 Burchellia bubalina Nutrition 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 235000002722 Dioscorea batatas Nutrition 0.000 abstract 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 abstract 1
- 240000001811 Dioscorea oppositifolia Species 0.000 abstract 1
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 abstract 1
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 1
- 241000545744 Hirudinea Species 0.000 abstract 1
- 244000241838 Lycium barbarum Species 0.000 abstract 1
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 1
- 235000015468 Lycium chinense Nutrition 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 abstract 1
- 241000283966 Pholidota <mammal> Species 0.000 abstract 1
- 241000157352 Uncaria Species 0.000 abstract 1
- 230000001914 calming effect Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 238000005728 strengthening Methods 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 description 10
- 210000004072 lung Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 7
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 210000003734 kidney Anatomy 0.000 description 6
- 210000000952 spleen Anatomy 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 3
- 230000034994 death Effects 0.000 description 3
- 210000002216 heart Anatomy 0.000 description 3
- 206010010904 Convulsion Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000406668 Loxodonta cyclotis Species 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 241000270708 Testudinidae Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001815 biotherapy Methods 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000001037 epileptic effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000000505 pernicious effect Effects 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
Abstract
The invention relates to a traditional Chinese medicine preparation for treating gastric cancer and a preparation method, and the traditional Chinese medicine preparation comprises twelve medicinal materials of achyranthes roots, wolfberry, uncaria, buffalo horns, angelica, tangerine peel, pangolin, gallnut, pseudo-ginseng, leech, Chinese yam, and dahurian angelica roots. The invention forms the traditional Chinese medicine preparation based on traditional Chinese medicine theory and modern research results; through synergism among the raw materials, the preparation can regulate yin-yang, remove pathogenic factors and strengthen body resistance, soften hardness and dissipate binds, promote the circulation of qi and absorb clots, clear heat and remove toxicity, promote metabolism, improve body immunity, improve internal environment, effectively inhibit and treat gastric malignant tumors, and reach the efficacy of reducing reflux, calming, removing tumor and strengthening body resistance, has no toxic or side effect, is low in price, convenient for taking, and convenient for large-scale popularization and application.
Description
Affiliated technical field
The present invention relates to the field of Chinese medicines, relate in particular to a kind of Chinese medicine preparation and preparation method for the treatment of gastric cancer.
Background technology
Along with the fast development of economy, the continuous deterioration of the quickening of rhythm of life and ecological environment, the cancer patient is also increasing year by year, brings white elephant and pressure for society and family.According to statistics, tumor incidence is with annual 3% to 5% Speed improving, and 80% new tumor occurs in China, India, the such developing country of Brazil among the newly-increased patient.Tumor is divided into optimum and pernicious, and malignant tumor is exactly the cancer that is commonly called as, and gastric cancer has accounted for again sizable proportion in malignant tumor, compatriots' cause of the death 1/4 is cancer at present, 1/4 of the cancer cause of the death is gastric cancer, and in the alimentary system malignant tumour death, approximately half is died from gastric cancer.The annual new gastric cancer more than 100 ten thousand in the whole world, China accounts for 42%, and is dead approximately 800,000, and China accounts for 35%, is one of the highest country of incidence gastric cancer rate and mortality rate, and M ﹠ M is that the world average level twice is many.
China has the name of disease of " tumor " as far back as apart from the modern approximately abundant Zhou Shidai in more than 3500 year on the inscriptions on bones or tortoise shells of Yin Dynasty ruins, this word reaches " staying " by " Epileptic " and forms, and the pathology understanding that at that time this disease is had " staying poly-not going " has been described.Tumor is that congestion, phlegm retention, foul smell stop gathering the vegetation that produces in tissue, and " rock " refers to the malignant tumor of body surface, therefore because of its quality very hard being referred to as, its meaning is with cancer word and general.The traditional Chinese medical science thinks that its etiology and pathogenesis is: the heresy of six climate exopathogens, the pent-up of feelings will, eating and drinking without temperance, internal organs are become estranged congenital factors.Its treatment is expelled pathogenetic factors and reinforced antipathogenetic qi also according to the pathology YIN and YANG balance regulating.Chinese medicine contains Multiple components, has the characteristics of multipath, too many levels and many target spots, can suppress from integral body generation, the development of tumor.Doctor trained in Western medicine then obtains certain effect mainly with operation, chemicotherapy processing, biotherapy, but its traumatic large, toxic and side effects is high and treatment cost is expensive is difficult to acceptance for ordinary populace, normal because over-treatment causes the adverse consequences that things turn out contrary to one's wishes, and the side effect severe patient can cause single system or multisystem nonfunction.
Preventing and treating in the process of tumor, Chinese medicine is improving body's immunity, is promoting apoptosis of tumor cells, inhibition tumor cell transfer etc. conveniently bringing into play outstanding effect, and Chinese medicine provides wide drug resource for the research of medicine for treating tumor thing.Chinese medicine and pharmacy be the Chinese nation with disease long-term struggle process in the treasure that accumulates, of long standing and well established, of extensive knowledge and profound scholarship.Chinese medicine and pharmacy is controlled and principle-method-recipe-medicines the cause of disease, pathogenesis, the dialectical opinion of cancer, unique theory and experience are arranged, especially modern age, centering medical applications modern science and technology were carried out system, deep research, inherited and developed theory and the method for Chinese medicine treatment cancer.
Summary of the invention
Task of the present invention provides a kind of Chinese medicine preparation and preparation method for the treatment of gastric cancer, and simultaneously, the present invention also provides the preparation method of the Chinese medicine preparation of this treatment gastric cancer.Under the guidance of theory of Chinese medical science, by the rational proportion of each medical material, synergism has good curative effect to treatment gastric cancer.
For achieving the above object, being implemented as follows of technical scheme of the present invention:
A kind of Chinese medicine preparation for the treatment of gastric cancer, raw material composition and the parts by weight of making described Effective Component of Chinese Medicine are:
50～70 parts of 50～75 parts of Cornu Bubalis of 60～80 parts of Ramulus Uncariae Cum Uncis of 60～80 parts of Fructus Lycii of Radix Achyranthis Bidentatae
60～80 parts of 45～55 parts of Galla Chinensiss of 50～75 parts of Squama Maniss of 40～60 parts of Pericarpium Citri Reticulataes of Radix Angelicae Sinensis
8～16 parts of 20～40 parts of Radixs Angelicae Dahuricae of 15～25 portions of Rhizoma Dioscoreaes of 30～50 portions of Hirudos of Radix Notoginseng
Raw material composition and the parts by weight of making described effective ingredient are:
55～68 parts of 56～70 parts of Cornu Bubalis of 68～75 parts of Ramulus Uncariae Cum Uncis of 68～75 parts of Fructus Lycii of Radix Achyranthis Bidentatae
68～75 parts of 47～52 parts of Galla Chinensiss of 56～70 parts of Squama Maniss of 42～57 parts of Pericarpium Citri Reticulataes of Radix Angelicae Sinensis
10～15 parts of 26～35 parts of Radixs Angelicae Dahuricae of 18～23 portions of Rhizoma Dioscoreaes of 35～45 portions of Hirudos of Radix Notoginseng
Raw material composition and the parts by weight of making described effective ingredient are:
60 parts of 65 parts of Cornu Bubalis of 70 parts of Ramulus Uncariae Cum Uncis of 70 parts of Fructus Lycii of Radix Achyranthis Bidentatae
70 parts of 50 parts of Galla Chinensiss of 65 parts of Squama Maniss of 48 parts of Pericarpium Citri Reticulataes of Radix Angelicae Sinensis
13 parts of 28 parts of Radixs Angelicae Dahuricae of 22 portions of Rhizoma Dioscoreaes of 40 portions of Hirudos of Radix Notoginseng
Raw material composition and the parts by weight of making described effective ingredient are:
65 parts of 68 parts of Cornu Bubalis of 74 parts of Ramulus Uncariae Cum Uncis of 74 parts of Fructus Lycii of Radix Achyranthis Bidentatae
72 parts of 51 parts of Galla Chinensiss of 67 parts of Squama Maniss of 55 parts of Pericarpium Citri Reticulataes of Radix Angelicae Sinensis
14 parts of 30 parts of Radixs Angelicae Dahuricae of 23 portions of Rhizoma Dioscoreaes of 42 portions of Hirudos of Radix Notoginseng
A kind of Chinese medicine preparation and preparation method for the treatment of gastric cancer comprises following processing step:
(1) Radix Achyranthis Bidentatae is carried out pulverization process, porphyrize is crossed 100 order fine powders, described Radix Achyranthis Bidentatae fine powder is carried out percolation with alcoholic solution process, and Recycled ethanol obtains the Radix Achyranthis Bidentatae percolate; During described percolation was processed, the w/v of Radix Achyranthis Bidentatae fine powder and ethanol was 1: 6～12.
(2) Fructus Lycii, Ramulus Uncariae Cum Uncis, Cornu Bubali, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Squama Manis, Galla Chinensis, Radix Notoginseng, Hirudo, Rhizoma Dioscoreae, the Radix Angelicae Dahuricae are decocted processing, obtain the decocting liquid of this ten Herba indigoferae Pseudotinctoriae, in decocting processing, the gross weight of this ten Herba indigoferae Pseudotinctoriae and the w/v of water are 1: 7～15.
(3) decocting liquid with gained ten Herba indigoferae Pseudotinctoriae in the step (2) filter, concentration, obtain concentrated solution; The relative density of described concentrated solution is 1.12～1.16 (45～50 ℃).
(4) concentrated solution and the Radix Achyranthis Bidentatae percolate that makes in the step (3) merged, carry out again filtration treatment, obtain described total filtrate.
(5) the total filtrate in the step (4) is concentrated, dried, add fluidizer, antiseptic and lubricant an amount of, granulate again, during granulation is incapsulated, and get final product.
The property of medicine of the used Chinese medicine of the present invention is as follows:
Radix Achyranthis Bidentatae: bitter, sour, property is put down; Return liver, kidney channel; Dispel the wind, blood circulation promoting and blood stasis dispelling, cure mainly the carbuncle malignant boil.
Fructus Lycii: sweet in the mouth, property are put down; Return liver, kidney, lung meridian; Nourishing the liver, nourishing kidney, lung moistening.
Ramulus Uncariae Cum Uncis: sweetness and bitterness, be slightly cold; Return Liver Channel, heart channel; Heat clearing away suppressing the hyperactive liver, endogenous wind stopping relieving convulsion.
Cornu Bubali: bitter salty, cold; Enter the heart, liver, spleen, stomach four warps; Heat clearing away, removing heat from blood, arresting convulsion, detoxifcation.
Radix Angelicae Sinensis: warm in nature, sweet in the mouth; Return liver, the heart, spleen channel; Enrich blood invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation, regulate body's immunity.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, bitter in the mouth; Enter spleen channel, stomach warp, lung meridian; In the accent, dampness, reduce phlegm.Temperature can circulation of qi promoting, and suffering can be dispersed, and is bitter and sluice.
Squama Manis: salty in the mouth, cold nature; Enter liver, stomach two warps; The logical internal organs of a surname, happy meridians, thoroughly reach close key, open blood clotting, loose blood is poly-, detumescence and apocenosis.
Galla Chinensis: sour in the mouth, puckery, cold in nature; Return lung, large intestine, kidney channel; Astringe the lung, hidroschesis, astringing intestine to stop diarrhea, controlling nocturnal emission with astringent drugs, hemostasis, detoxifcation.
Radix Notoginseng: warm in nature, sweet in the mouth, little hardship; Return liver, stomach warp; Hemostasis, dissipating blood stasis, detumescence, pain relieving, antiinflammatory, antitumor.
Hirudo: salty, bitter, flat, slightly poisonous; Return Liver Channel; Removing blood stasis, removing blood stasis, stimulate the menstrual flow.
Rhizoma Dioscoreae: sweet in the mouth, property are put down; Enter lung, spleen, kidney channel; Tonifying the spleen and stomach, lung benefiting kidney.
The Radix Angelicae Dahuricae: warm in nature, acrid in the mouth; Enter lung, spleen, stomach warp; Wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.
The present invention compared with prior art has following beneficial effect:
The present invention is as according to the Chinese medicine preparation that forms take theory of Chinese medical science and modern study result, synergism between each raw material, can YIN and YANG balance regulating, expel pathogenetic factors and reinforce antipathogenetic qi, hard masses softening and resolving, regulating qi to disperse stagnation, heat-clearing and toxic substances removing, promotion metabolism, improve immunity of organisms, improve internal milieu, can establishment and treatment stomach malignant tumor, reach sending down the abnormal ascending QI, gentle, dispersing tumor righting effect, have no side effect, cheap, taking convenience is convenient to large scale application.
The specific embodiment
Below in conjunction with specific embodiment the present invention is further elaborated.
Embodiment 1
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and parts by weight are:
50～70 parts of 50～75 parts of Cornu Bubalis of 60～80 parts of Ramulus Uncariae Cum Uncis of 60～80 parts of Fructus Lycii of Radix Achyranthis Bidentatae
60～80 parts of 45～55 parts of Galla Chinensiss of 50～75 parts of Squama Maniss of 40～60 parts of Pericarpium Citri Reticulataes of Radix Angelicae Sinensis
8～16 parts of 20～40 parts of Radixs Angelicae Dahuricae of 15～25 portions of Rhizoma Dioscoreaes of 30～50 portions of Hirudos of Radix Notoginseng
The processing step of the above-mentioned Chinese medicine preparation preparation method of the present invention is:
(1) Radix Achyranthis Bidentatae is carried out pulverization process, porphyrize is crossed 100 order fine powders, described Radix Achyranthis Bidentatae fine powder is carried out percolation with alcoholic solution process, and Recycled ethanol obtains the Radix Achyranthis Bidentatae percolate; During described percolation was processed, the w/v of Radix Achyranthis Bidentatae fine powder and ethanol was 1: 6～12.
(2) Fructus Lycii, Ramulus Uncariae Cum Uncis, Cornu Bubali, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Squama Manis, Galla Chinensis, Radix Notoginseng, Hirudo, Rhizoma Dioscoreae, the Radix Angelicae Dahuricae are decocted processing, obtain the decocting liquid of this ten Herba indigoferae Pseudotinctoriae, in decocting processing, the gross weight of this ten Herba indigoferae Pseudotinctoriae and the w/v of water are 1: 7～15.
(3) decocting liquid with gained ten Herba indigoferae Pseudotinctoriae in the step (2) filter, concentration, obtain concentrated solution; The relative density of described concentrated solution is 1.12～1.16 (45～50 ℃).
(4) concentrated solution and the Radix Achyranthis Bidentatae percolate that makes in the step (3) merged, carry out again filtration treatment, obtain described total filtrate.
(5) the total filtrate in the step (4) is concentrated, dried, add fluidizer, antiseptic and lubricant an amount of, granulate again, during granulation is incapsulated, and get final product.
Embodiment 2
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and parts by weight are:
55～68 parts of 56～70 parts of Cornu Bubalis of 68～75 parts of Ramulus Uncariae Cum Uncis of 68～75 parts of Fructus Lycii of Radix Achyranthis Bidentatae
68～75 parts of 47～52 parts of Galla Chinensiss of 56～70 parts of Squama Maniss of 42～57 parts of Pericarpium Citri Reticulataes of Radix Angelicae Sinensis
10～15 parts of 26～35 parts of Radixs Angelicae Dahuricae of 18～23 portions of Rhizoma Dioscoreaes of 35～45 portions of Hirudos of Radix Notoginseng
The Chinese medicine preparation preparation method processing step of the present embodiment is identical with embodiment 1.
Embodiment 3
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and parts by weight are:
60 parts of 65 parts of Cornu Bubalis of 70 parts of Ramulus Uncariae Cum Uncis of 70 parts of Fructus Lycii of Radix Achyranthis Bidentatae
70 parts of 50 parts of Galla Chinensiss of 65 parts of Squama Maniss of 48 parts of Pericarpium Citri Reticulataes of Radix Angelicae Sinensis
13 parts of 28 parts of Radixs Angelicae Dahuricae of 22 portions of Rhizoma Dioscoreaes of 40 portions of Hirudos of Radix Notoginseng
The Chinese medicine preparation preparation method processing step of the present embodiment is identical with embodiment 1.
Embodiment 4
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and parts by weight are:
65 parts of 68 parts of Cornu Bubalis of 74 parts of Ramulus Uncariae Cum Uncis of 74 parts of Fructus Lycii of Radix Achyranthis Bidentatae
72 parts of 51 parts of Galla Chinensiss of 67 parts of Squama Maniss of 55 parts of Pericarpium Citri Reticulataes of Radix Angelicae Sinensis
14 parts of 30 parts of Radixs Angelicae Dahuricae of 23 portions of Rhizoma Dioscoreaes of 42 portions of Hirudos of Radix Notoginseng
The Chinese medicine preparation preparation method processing step of the present embodiment is identical with embodiment 1.
Clinical data:
1, case is selected
As the Chinese medicine preparation for the treatment of gastric cancer, the patients with gastric cancer 258 routine clinical observations that selection is made a definite diagnosis, patient is divided into two groups at random, treatment group 129 examples, male's 66 examples wherein, women's 63 examples, 22～80 years old age, 56.7 years old mean age, the course of disease 5～20 months, average 9.8 months.Matched group 129 examples, male's 71 examples wherein, women's 58 examples, 25～78 years old age, 55.4 years old mean age, the course of disease 7～18 months, average 8.6 months.Two groups of qualifications and record of service are basically identical, without significant difference, have comparability.
2, the treatment group patient takes Chinese medicine preparation of the present invention, oral 3 times of every day of adult, each 2 capsules, 40 days courses for the treatment of.Matched group adopts chemotherapy and radiation.
3, efficacy determination:
(1) produce effects: tumor tumor body dwindles more than 10%, and subjective symptoms is obviously improved, and cardinal symptom disappears;
(2) effective: tumor tumor body dwindles 3～10%, and clinical symptoms is obviously improved;
(3) improve: tumor tumor body dwindles 1～3%, and clinical symptoms is improved;
(4) invalid: tumor tumor body continues to increase, and clinical symptoms is without improving or increasing the weight of.
4, result
Take in the treatment group of Chinese medicine preparation of the present invention, produce effects 69 examples, effective 34 examples are improved 21 examples, invalid 5 examples, total effective rate 96.1%
Produce effects 48 examples in the matched group, effective 25 examples are improved 11 examples, invalid 45 examples, total effective rate 65.1%.
Above result's demonstration, the total effective rate for the treatment of group is apparently higher than matched group.
Claims (5)
1. Chinese medicine preparation for the treatment of gastric cancer is characterized in that: the raw material of making described Effective Component of Chinese Medicine forms and parts by weight are:
50～70 parts of 50～75 parts of Cornu Bubalis of 60～80 parts of Ramulus Uncariae Cum Uncis of 60～80 parts of Fructus Lycii of Radix Achyranthis Bidentatae
60～80 parts of 45～55 parts of Galla Chinensiss of 50～75 parts of Squama Maniss of 40～60 parts of Pericarpium Citri Reticulataes of Radix Angelicae Sinensis
8～16 parts of 20～40 parts of Radixs Angelicae Dahuricae of 15～25 portions of Rhizoma Dioscoreaes of 30～50 portions of Hirudos of Radix Notoginseng.
2. a kind of Chinese medicine preparation for the treatment of gastric cancer according to claim 1 is characterized in that: the raw material of making described effective ingredient forms and parts by weight are:
55～68 parts of 56～70 parts of Cornu Bubalis of 68～75 parts of Ramulus Uncariae Cum Uncis of 68～75 parts of Fructus Lycii of Radix Achyranthis Bidentatae
68～75 parts of 47～52 parts of Galla Chinensiss of 56～70 parts of Squama Maniss of 42～57 parts of Pericarpium Citri Reticulataes of Radix Angelicae Sinensis
10～15 parts of 26～35 parts of Radixs Angelicae Dahuricae of 18～23 portions of Rhizoma Dioscoreaes of 35～45 portions of Hirudos of Radix Notoginseng.
3. a kind of Chinese medicine preparation for the treatment of gastric cancer according to claim 1 is characterized in that: the raw material of making described effective ingredient forms and parts by weight are:
60 parts of 65 parts of Cornu Bubalis of 70 parts of Ramulus Uncariae Cum Uncis of 70 parts of Fructus Lycii of Radix Achyranthis Bidentatae
70 parts of 50 parts of Galla Chinensiss of 65 parts of Squama Maniss of 48 parts of Pericarpium Citri Reticulataes of Radix Angelicae Sinensis
13 parts of 28 parts of Radixs Angelicae Dahuricae of 22 portions of Rhizoma Dioscoreaes of 40 portions of Hirudos of Radix Notoginseng.
4. a kind of Chinese medicine preparation for the treatment of gastric cancer according to claim 1 is characterized in that: the raw material of making described effective ingredient forms and parts by weight are:
65 parts of 68 parts of Cornu Bubalis of 74 parts of Ramulus Uncariae Cum Uncis of 74 parts of Fructus Lycii of Radix Achyranthis Bidentatae
72 parts of 51 parts of Galla Chinensiss of 67 parts of Squama Maniss of 55 parts of Pericarpium Citri Reticulataes of Radix Angelicae Sinensis
14 parts of 30 parts of Radixs Angelicae Dahuricae of 23 portions of Rhizoma Dioscoreaes of 42 portions of Hirudos of Radix Notoginseng.
5. preparation method such as claim 1-4 Chinese medicine preparation for the treatment of gastric cancer as described in each is characterized in that: comprise following processing step:
(1) Radix Achyranthis Bidentatae is carried out pulverization process, porphyrize is crossed 100 order fine powders, described Radix Achyranthis Bidentatae fine powder is carried out percolation with alcoholic solution process, and Recycled ethanol obtains the Radix Achyranthis Bidentatae percolate; During described percolation was processed, the w/v of Radix Achyranthis Bidentatae fine powder and ethanol was 1: 6～12;
(2) Fructus Lycii, Ramulus Uncariae Cum Uncis, Cornu Bubali, Radix Angelicae Sinensis, Pericarpium Citri Reticulatae, Squama Manis, Galla Chinensis, Radix Notoginseng, Hirudo, Rhizoma Dioscoreae, the Radix Angelicae Dahuricae are decocted processing, obtain the decocting liquid of this ten Herba indigoferae Pseudotinctoriae, in decocting processing, the gross weight of this ten Herba indigoferae Pseudotinctoriae and the w/v of water are 1: 7～15;
(3) decocting liquid with gained ten Herba indigoferae Pseudotinctoriae in the step (2) filter, concentration, obtain concentrated solution; The relative density of described concentrated solution in the time of 45～50 ℃ is 1.12～1.16;
(4) concentrated solution and the Radix Achyranthis Bidentatae percolate that makes in the step (3) merged, carry out again filtration treatment, obtain described total filtrate;
(5) the total filtrate in the step (4) is concentrated, dried, add fluidizer, antiseptic and lubricant an amount of, granulate again, during granulation is incapsulated, and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100866541A CN102526431B (en) | 2012-03-29 | 2012-03-29 | Traditional Chinese medicine preparation for treating gastric cancer and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100866541A CN102526431B (en) | 2012-03-29 | 2012-03-29 | Traditional Chinese medicine preparation for treating gastric cancer and preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102526431A CN102526431A (en) | 2012-07-04 |
| CN102526431B true CN102526431B (en) | 2013-10-16 |
Family
ID=46335251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100866541A Active CN102526431B (en) | 2012-03-29 | 2012-03-29 | Traditional Chinese medicine preparation for treating gastric cancer and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102526431B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104771553A (en) * | 2015-05-07 | 2015-07-15 | 王小华 | Invigorating spleen and kidney preparation for treatment of gastric cancer and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1695719A (en) * | 2005-04-26 | 2005-11-16 | 上海千兆商务咨询有限公司 | Chinese traditional medicine for preventing and treating cancer |
| CN101862360A (en) * | 2010-05-25 | 2010-10-20 | 中国中医科学院中药研究所 | New application of achyranthes for preparing medicines for preventing and/or treating gastric precancerous lesion and gastric cancer |
-
2012
- 2012-03-29 CN CN2012100866541A patent/CN102526431B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1695719A (en) * | 2005-04-26 | 2005-11-16 | 上海千兆商务咨询有限公司 | Chinese traditional medicine for preventing and treating cancer |
| CN101862360A (en) * | 2010-05-25 | 2010-10-20 | 中国中医科学院中药研究所 | New application of achyranthes for preparing medicines for preventing and/or treating gastric precancerous lesion and gastric cancer |
Non-Patent Citations (6)
| Title |
|---|
| 吴洁等.孙桂芝治疗胃癌的常用药对释义.《北京中医药》.2009,第28卷(第2期),第96-97页. |
| 吴绪祥等.祛邪法在胃癌治疗中的运用.《第二十一届全国中西医结合学会消化系统疾病学术会议》.2009,第486-487页. |
| 孙桂芝治疗胃癌的常用药对释义;吴洁等;《北京中医药》;20090225;第28卷(第2期);第96-97页 * |
| 杨健武.胃癌的中医病机证治.《云南中医学院学报》.1993,第16卷(第3期),第34-38、43页. |
| 祛邪法在胃癌治疗中的运用;吴绪祥等;《第二十一届全国中西医结合学会消化系统疾病学术会议》;20090723;第486-487页 * |
| 胃癌的中医病机证治;杨健武;《云南中医学院学报》;19931001;第16卷(第3期);第34-38、43页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102526431A (en) | 2012-07-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103768398B (en) | Traditional Chinese medicine composition for treating advanced lung tumors | |
| CN102579755A (en) | Chinese medicinal formula for treating chronic renal failure | |
| CN102526431B (en) | Traditional Chinese medicine preparation for treating gastric cancer and preparation method | |
| CN102988781A (en) | Traditional Chinese medicine liniment for inhibiting cancer and relieving pain | |
| CN102228504A (en) | Formula of anticancer Chinese medicine and process for preparing products of anticancer Chinese medicine | |
| CN102579677B (en) | Chinese medicinal composition for treating brain glioma | |
| CN102697984B (en) | Chinese medicinal external application preparation for treating acute mastitis | |
| CN103610896A (en) | Exogenous cough treatment traditional Chinese medicine | |
| CN105902897A (en) | Pharmaceutical preparation for treating pancreatic cancer and application thereof | |
| CN102266434B (en) | Chinese medicinal composition for resisting tumor metastasis and preparation method thereof | |
| CN103611057A (en) | Breast cancer capsule for treating breast cancer and preparation method therefor | |
| CN103768519B (en) | A kind of compound medicine improving cyclophosphamide antitumor curative effect and preparation method thereof | |
| CN103494939A (en) | Traditional Chinese medicine for treating senile habitual constipation | |
| CN102772763B (en) | Traditional Chinese medicinal composition for resisting tumor metastasis and method for preparing traditional Chinese medicinal composition | |
| CN101693096A (en) | Medicament for treating liver cancer and preparation method thereof | |
| CN102688422B (en) | Glabrous greenbrier rhizome Chinese medicinal oral liquid for treating chronic hepatitis and preparation method thereof | |
| CN102488804A (en) | Traditional Chinese medicine for treating cirrhosis | |
| CN107243071B (en) | Traditional Chinese medicine preparation for assisting lung cancer chemotherapy and preparation method thereof | |
| CN105770515A (en) | Traditional Chinese medicinal composition for treating prostatitis and preparation method of traditional Chinese medicinal composition | |
| CN105456447A (en) | Folium artemisiae argyi-containing traditional Chinese medicine composition with function of promoting blood circulation to remove stasis and preparation method thereof | |
| CN105617207A (en) | Formula of traditional Chinese medicine for treating Qi deficiency and evil stasis type tympanitis | |
| CN105381444A (en) | Traditional Chinese medicine decoction for treating thyroid cancer | |
| CN102302718B (en) | Antitumor medicinal composition and preparation method thereof | |
| CN115501314A (en) | Compound traditional Chinese medicine composition for inhibiting tumor liver metastasis and preparation method and application thereof | |
| CN104258276A (en) | Traditional Chinese medicine composition for treating non-alcoholic fatty liver disease and preparation method of traditional Chinese medicine composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: RUDONG TECHNOLOGY CENTER Free format text: FORMER OWNER: ZHAI XIJU Effective date: 20150104 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 271000 TAIAN, SHANDONG PROVINCE TO: 226400 NANTONG, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20150104 Address after: 226400 No. 66 Youyi West Road, dug Town, Rudong County, Jiangsu, Nantong Patentee after: Rudong science and Technology Center Address before: 271000 Tai'an Tumour Prevention and Treatment Hospital, 262 Tai Dong Road, Taishan District, Shandong, Tai'an Patentee before: Di Xiju |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20200415 Address after: No. 10, Fandi South Road, juegang Town, Rudong County, Nantong City, Jiangsu Province Patentee after: Rudong industrial and commercial information consulting service center Address before: 226400 No. 66 Youyi West Road, dug Town, Rudong County, Jiangsu, Nantong Patentee before: Rudong science and Technology Center |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20210827 Address after: 226400 No.8, wisdom Avenue, Donghu scenic area, Dayu Town, Rudong County, Nantong City, Jiangsu Province Patentee after: Nantong Donghu International Travel Agency Co., Ltd Address before: 226400 No.10 Fandi South Road, juegang Town, Rudong County, Nantong City, Jiangsu Province Patentee before: Rudong industrial and commercial information consulting service center |
|
| TR01 | Transfer of patent right |