CN107243071B - Traditional Chinese medicine preparation for assisting lung cancer chemotherapy and preparation method thereof - Google Patents

Traditional Chinese medicine preparation for assisting lung cancer chemotherapy and preparation method thereof Download PDF

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CN107243071B
CN107243071B CN201710028639.4A CN201710028639A CN107243071B CN 107243071 B CN107243071 B CN 107243071B CN 201710028639 A CN201710028639 A CN 201710028639A CN 107243071 B CN107243071 B CN 107243071B
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traditional chinese
chinese medicine
radix
rhizome
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CN107243071A (en
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杨喜花
任连生
张蘋
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Shanxi Tumour Institute
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Shanxi Tumour Institute
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    • A61K36/906—Zingiberaceae (Ginger family)
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Abstract

The invention relates to a traditional Chinese medicine preparation for assisting lung cancer chemotherapy, which comprises the following raw materials of, by weight, adenophora tetraphylla, rabdosia rubescens, radix ophiopogonis, dandelion, radix rehmanniae, lalang grass rhizome, codonopsis pilosula, astragalus membranaceus, herba cirsii, garden burnet, lily, rhizoma anemarrhenae, purslane, Chinese pulsatilla root, paris rhizome, reed rhizome, cassia seed, plantain seed, tuckahoe, mulberry leaf, radix bupleuri, fructus cannabis, cortex lycii radicis, radix sophorae flavescentis, cistanche, bighead atractylodes rhizome, cynanchum glaucescens, greater celandine, ginkgo, liquorice, ginger and Chinese date. Soaking the raw materials, extracting with water, collecting extractive solution, filtering, concentrating into soft extract, adding sucrose powder, and granulating. The traditional Chinese medicine preparation is used as an auxiliary medicine in the process of radiotherapy and chemotherapy of lung cancer, and has the effects of nourishing yin and moistening lung, clearing away heat and toxic materials, tonifying qi and nourishing blood, relaxing bowel, inhibiting tumors and improving the effect of radiotherapy and chemotherapy.

Description

Traditional Chinese medicine preparation for assisting lung cancer chemotherapy and preparation method thereof
Technical Field
The invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine preparation prepared by extracting a traditional Chinese medicine compound, which can be used for adjuvant therapy in the processes of radiotherapy and chemotherapy of lung cancer.
Background
In the advanced stage of lung cancer, chemotherapy or radiotherapy can be adopted only because the chance of operation is lost, so that the aim of relieving the disease progression is fulfilled. In the course of chemotherapy or radiotherapy, the patient mostly has the complications of body weakness, fever, high fever and the like, and the complications do not work by using common anti-inflammatory and antipyretic medicines, thereby bringing great pain to the patient. And most patients will therefore discontinue treatment, affecting the effectiveness of clinical treatment.
Disclosure of Invention
The invention provides a traditional Chinese medicine preparation for assisting lung cancer chemotherapy and a preparation method thereof.
In order to solve the technical problems, according to one aspect of the invention, the traditional Chinese medicine preparation for assisting lung cancer chemotherapy comprises, by weight, 9-15 parts of adenophora tetraphylla, 9-15 parts of rabdosia rubescens, 9-15 parts of radix ophiopogonis, 6-9 parts of dandelion, 9-15 parts of radix rehmanniae, 9-15 parts of lalang grass rhizome, 9-15 parts of codonopsis pilosula, 9-15 parts of astragalus membranaceus, 9-15 parts of field thistle, 3-9 parts of sanguisorba officinalis, 3-9 parts of lily, 3-9 parts of rhizoma anemarrhenae, 9-15 parts of purslane, 9-15 parts of pulsatilla chinensis, 3-9 parts of manyleaf paris rhizome, 9-15 parts of rhizoma phragmitis, 9-15 parts of semen cassiae, 6-9 parts of semen plantaginis, 9-15 parts of tuckahoe, 6-9 parts of mulberry leaves, 6-9 parts of radix bupleuri, 9-15 parts of fructus, 6-9 parts of cortex lycii radicis, 6-9 parts of radix sophorae flavescentis, 9-15 parts of cistanche, 9-15 parts of bighead atractylodes rhizome, 3-9 parts of cynanchum glaucescens, 9-15 parts of celandine, 6-9 parts of ginkgo, 6-9 parts of liquorice, 6-9 parts of ginger and 9-15 parts of Chinese date.
Further, the traditional Chinese medicine preparation for assisting lung cancer chemotherapy comprises the following raw material medicines of 15 parts of adenophora tetraphylla, 15 parts of rabdosia rubescens, 15 parts of radix ophiopogonis, 9 parts of dandelion, 15 parts of radix rehmanniae, 15 parts of lalang grass rhizome, 15 parts of codonopsis pilosula, 15 parts of astragalus membranaceus, 15 parts of herba cephalanoploris, 9 parts of garden burnet, 9 parts of lily, 9 parts of rhizoma anemarrhenae, 15 parts of purslane, 15 parts of Chinese pulsatilla root, 9 parts of manyleaf paris rhizome, 15 parts of reed rhizome, 15 parts of semen cassiae, 9 parts of semen plantaginis, 15 parts of tuckahoe, 9 parts of folium mori, 9 parts of radix bupleuri, 15 parts of fructus cannabis, 9 parts of cortex lycii radicis, 9 parts of radix sophorae flavescentis, 15 parts of cistanche, 15 parts of rhizoma atractylodis macrocephalae, 9 parts of cynanchum glaucescens.
According to the theory of clearing away heat and toxic materials and strengthening body resistance to eliminate pathogenic factors of the traditional Chinese medicine, the traditional Chinese medicines such as the rehmannia root, the adenophora tetraphylla, the dwarf lilyturf tuber and the rhizoma anemarrhenae for nourishing yin and clearing away heat, tonifying qi and promoting fluid production are selected to nourish yin and clear away heat, the traditional Chinese medicines such as the codonopsis pilosula, the bighead atractylodes rhizome, the poria cocos, the astragalus mongholicus and the liquorice are selected to strengthen spleen and tonify qi, tonify qi and nourish blood, and the traditional Chinese medicines such as the; chinese herbal medicines with anti-tumor effect, such as radix sophorae flavescentis, paris rhizome, rabdosia rubescens and the like, are selected to inhibit the growth of tumor cells; semen Cassiae, semen plantaginis, Poria, rhizoma Phragmitis, etc. with effects of clearing heat and promoting diuresis are selected to promote discharge of toxic substances; meanwhile, cistanche for tonifying kidney and replenishing essence and fructus cannabis for relaxing bowel are selected; herba Chelidonii has spasmolytic and analgesic effects; radix bupleuri harmonizes yin and yang, combines various medicines, and has the effects of nourishing yin, clearing heat, expelling toxin, eliminating evil, strengthening spleen, tonifying qi and inhibiting tumor cells.
According to another aspect of the invention, a preparation method of a traditional Chinese medicine preparation for assisting lung cancer chemotherapy is provided, wherein raw material medicines are soaked and extracted with water, then an extracting solution is collected, the extracting solution is filtered and concentrated into thick paste, and sucrose powder is added into the thick paste to prepare granules.
Further, adding water with the mass 6-8 times of the total mass of the raw material medicines into the raw material medicines, soaking for 20-50 minutes, heating and boiling, keeping for 40-70 minutes for carrying out first extraction, and collecting first extraction liquid; adding water with the mass 3-5 times of the total mass of the raw materials into the residue, heating and boiling for 20-60 minutes, and collecting the second extracting solution; mixing the two extractive solutions, filtering with gauze, concentrating the filtrate under reduced pressure to obtain soft extract, adding sucrose powder into the soft extract, granulating, drying, sieving, packaging, and sealing.
According to another aspect of the invention, the invention also provides application of the traditional Chinese medicine preparation in preparation of a medicine for assisting lung cancer radiotherapy and chemotherapy. Experiments show that the traditional Chinese medicine preparation disclosed by the invention can be used together with mitomycin, so that the average survival time of mice bearing Lewis lung cancer tumors can be remarkably prolonged, the treatment effect of the chemotherapeutic mitomycin is improved, and the traditional Chinese medicine preparation has remarkable synergistic and attenuated effects.
The traditional Chinese medicine preparation of the invention has the main function indications: is used as adjuvant medicine for radiotherapy and chemotherapy of lung cancer, and has effects of nourishing yin, moistening lung, clearing away heat and toxic materials, invigorating qi, nourishing blood, loosening bowel to relieve constipation, inhibiting tumor, and improving radiotherapy and chemotherapy effects.
The using method comprises the following steps: the medicine is taken after meals, 15 g is taken after being mixed with boiled water, and the medicine is taken twice a day.
The invention applies the theories of traditional Chinese medicine for nourishing yin, moistening lung, nourishing yin, promoting the production of body fluid and clearing heat and toxic materials, selects a plurality of traditional Chinese medicines with corresponding functions to form a compound preparation, solves the practical problems encountered in clinic, and adds the traditional Chinese medicine compound preparation in the process of chemotherapy to treat or condition various fever symptoms of tumors caused by radiotherapy or chemotherapy so as to achieve the purposes of relieving pain and improving treatment effect.
Detailed Description
In a typical embodiment of the invention, the traditional Chinese medicine preparation for assisting lung cancer chemotherapy comprises, by weight, 9-15 parts of adenophora tetraphylla, 9-15 parts of rabdosia rubescens, 9-15 parts of radix ophiopogonis, 6-9 parts of dandelion, 9-15 parts of radix rehmanniae, 9-15 parts of lalang grass rhizome, 9-15 parts of codonopsis pilosula, 9-15 parts of astragalus membranaceus, 9-15 parts of field thistle, 3-9 parts of sanguisorba officinalis, 3-9 parts of lily, 3-9 parts of rhizoma anemarrhenae, 9-15 parts of purslane, 9-15 parts of pulsatilla chinensis, 3-9 parts of manyleaf paris rhizome, 9-15 parts of rhizoma phragmitis, 9-15 parts of semen cassiae, 6-9 parts of semen plantaginis, 9-15 parts of tuckahoe, 6-9 parts of folium mori, 6-9 parts of radix bupleuri, 9-15 parts of fructus cannabis, 6-9 parts of cortex lycii radicis, and a, 6-9 parts of radix sophorae flavescentis, 9-15 parts of cistanche, 9-15 parts of bighead atractylodes rhizome, 3-9 parts of cynanchum glaucescens, 9-15 parts of celandine, 6-9 parts of ginkgo, 6-9 parts of liquorice, 6-9 parts of ginger and 9-15 parts of Chinese date.
In a preferred embodiment, the traditional Chinese medicine preparation for assisting lung cancer chemotherapy comprises the following raw material medicines of 15 parts of adenophora tetraphylla, 15 parts of rabdosia rubescens, 15 parts of radix ophiopogonis, 9 parts of dandelion, 15 parts of radix rehmanniae, 15 parts of lalang grass rhizome, 15 parts of codonopsis pilosula, 15 parts of astragalus membranaceus, 15 parts of herba cirsii, 9 parts of sanguisorba officinalis, 9 parts of lily, 9 parts of rhizoma anemarrhenae, 15 parts of purslane, 15 parts of pulsatilla chinensis, 9 parts of pariphyllin, 15 parts of reed rhizome, 15 parts of semen cassiae, 9 parts of semen plantaginis, 15 parts of tuckahoe, 9 parts of folium mori, 9 parts of radix bupleuri, 15 parts of fructus cannabis, 9 parts of cortex lycii radicis, 9 parts of radix sophorae flavescentis, 15 parts of cistanche, 15 parts of rhizoma atractylodis macrocephalae, 9 parts of cynanchum glaucescens, 15 parts of cel.
In a typical embodiment of the present invention, a preparation method of a traditional Chinese medicine preparation for assisting lung cancer chemotherapy is provided, wherein raw material medicines are soaked and extracted with water, then an extracting solution is collected, the extracting solution is filtered and concentrated into a thick paste, and sucrose powder is added into the thick paste to prepare granules.
In a specific embodiment, the raw material medicines are added with water with 6-8 times of the total mass of the raw material medicines and soaked for 20-50 minutes, the mixture is heated and boiled and then kept for 40-70 minutes for carrying out first extraction, and a first extracting solution is collected; adding water with the mass 3-5 times of the total mass of the raw materials into the residue, heating and boiling for 20-60 minutes, and collecting the second extracting solution; mixing the two extractive solutions, filtering with gauze, concentrating the filtrate under reduced pressure to obtain soft extract, adding sucrose powder into the soft extract, granulating, drying, sieving, packaging, and sealing.
The technical solution and the advantages of the present invention will be further clearly and completely described with reference to the following embodiments.
Example 1
The prescription composition is as follows: 15 g of adenophora tetraphylla, 15 g of rabdosia rubescens, 15 g of radix ophiopogonis, 9 g of dandelion, 15 g of radix rehmanniae, 15 g of lalang grass rhizome, 15 g of codonopsis pilosula, 15 g of astragalus membranaceus, 15 g of herba cephalanoploris, 9 g of garden burnet, 9 g of lily, 9 g of rhizoma anemarrhenae, 15 g of purslane, 15 g of Chinese pulsatilla root, 9 g of paris rhizome, 15 g of rhizoma phragmitis, 15 g of semen cassiae, 9 g of semen plantaginis, 15 g of tuckahoe, 9 g of mulberry leaf, 9 g of radix bupleuri, 15 g of fructus cannabis, 9 g of cortex lycii radicis, 9 g of radix sophorae flavescentis, 15 g of cistanche, 15 g of bighead atractylodes rhizome, 9 g of cynanchum glaucescens, 15 g of celandi.
Adding 3072ml of purified water into the raw materials, soaking for 30 minutes, heating to boil, keeping for 60 minutes for carrying out primary extraction, and collecting primary extract; adding 1920ml purified water into the residue, heating and boiling, maintaining for 40 min, and collecting the second extractive solution; mixing the two extractive solutions, filtering with 4 layers of gauze, concentrating the filtrate under reduced pressure to obtain soft extract, oven drying, pulverizing to obtain dried extract 115.2 g, adding sucrose powder 82.8 g, mixing, granulating, drying, sieving, subpackaging into 15 g small bags, and sealing.
Example 2
The prescription composition is as follows: 9 g of adenophora tetraphylla, 9 g of rabdosia rubescens, 9 g of radix ophiopogonis, 6 g of dandelion, 9 g of radix rehmanniae, 9 g of lalang grass rhizome, 9 g of codonopsis pilosula, 9 g of astragalus membranaceus, 9 g of herba cephalanoploris, 3 g of garden burnet, 3 g of lily, 3 g of rhizoma anemarrhenae, 9 g of purslane, 9 g of Chinese pulsatilla root, 3 g of paris rhizome, 9 g of rhizoma phragmitis, 9 g of semen cassiae, 6 g of semen plantaginis, 9 g of tuckahoe, 6 g of mulberry leaf, 6 g of radix bupleuri, 9 g of fructus cannabis, 6 g of cortex lycii radicis, 6 g of radix sophorae flavescentis, 9 g of cistanche, 9 g of bighead atractylodes rhizome, 3 g of rhizoma cynanchi, 9 g of celandine, 6.
Adding 1386ml of purified water into the raw materials, soaking for 20 minutes, heating and boiling, keeping for 40 minutes for carrying out primary extraction, and collecting primary extract; adding 693ml purified water into the residue, heating and boiling, maintaining for 20 min, and collecting the second extractive solution; mixing the two extractive solutions, filtering with 4 layers of gauze, concentrating the filtrate under reduced pressure to obtain soft extract, oven drying, pulverizing to obtain dry extract 75 g, adding sucrose powder 40.5 g, mixing, granulating, drying, sieving, subpackaging into 15 g small bags, and sealing.
Example 3
The prescription composition is as follows: 10 g of adenophora tetraphylla, 12 g of rabdosia rubescens, 14 g of dwarf lilyturf tuber, 8 g of dandelion, 12 g of radix rehmanniae, 13 g of cogongrass rhizome, 10 g of codonopsis pilosula, 14 g of astragalus membranaceus, 12 g of field thistle, 5 g of garden burnet root, 6 g of lily, 8 g of rhizoma anemarrhenae, 11 g of purslane, 13 g of Chinese pulsatilla root, 7 g of paris rhizome, 12 g of reed rhizome, 14 g of cassia seed, 7 g of plantain seed, 13 g of tuckahoe, 8 g of mulberry leaf, 8 g of radix bupleuri, 13 g of fructus cannabis, 8 g of cortex lycii radicis, 7 g of sophora flavescens, 11 g of cistanche, 12 g of bighead atractylodes rhizome, 7 g of cynanchum glaucescens, 13 g of celandi.
Adding 2584ml of purified water into the raw materials, soaking for 50 minutes, heating to boil, keeping for 70 minutes for carrying out primary extraction, and collecting primary extract; adding 1615ml purified water into the residue, boiling, maintaining for 60 min, and collecting the second extractive solution; mixing the two extractive solutions, filtering with 4 layers of gauze, concentrating the filtrate under reduced pressure to obtain soft extract, oven drying, pulverizing to obtain dried extract 92 g, adding sucrose powder 69.5 g, mixing, granulating, drying, sieving, subpackaging into 15 g small bags, and sealing.
Example 4
The prescription composition is as follows: 12 g of adenophora tetraphylla, 11 g of rabdosia rubescens, 12 g of ophiopogon root, 7 g of dandelion, 10 g of radix rehmanniae, 11 g of cogongrass rhizome, 14 g of codonopsis pilosula, 10 g of astragalus membranaceus, 14 g of herba cephalanoploris, 7 g of sanguisorba officinalis, 8 g of lily, 4g of rhizoma anemarrhenae, 13 g of purslane, 10 g of Chinese pulsatilla root, 5 g of paris rhizome, 10 g of rhizoma phragmitis, 11 g of semen cassiae, 8 g of semen plantaginis, 11 g of tuckahoe, 7 g of mulberry leaf, 7 g of radix bupleuri, 10 g of fructus cannabis, 7 g of cortex lycii radicis, 8 g of radix sophorae flavescentis, 14 g of cistanche, 13 g of bighead atractylodes rhizome, 5 g of rhizoma cynanchi, 10 g of celandi.
Adding 1950ml of purified water into the raw materials, soaking for 40 minutes, heating to boil, keeping for 50 minutes for primary extraction, and collecting primary extract; adding 1200ml of purified water into the residue, heating and boiling, keeping for 30 minutes, and collecting the second extracting solution; mixing the two extractive solutions, filtering with 4 layers of gauze, concentrating the filtrate under reduced pressure to obtain soft extract, oven drying, pulverizing to obtain dried extract 90 g, adding sucrose powder 62.5 g, mixing, granulating, drying, sieving, subpackaging into 15 g small bags, and sealing.
The following is the experimental process and results of the adjuvant therapy effect of the traditional Chinese medicine compound preparation of the invention on the mouse transplanted lung cancer.
The purpose is as follows: the synergistic effect of the traditional Chinese medicine compound preparation on mitomycin on inhibition of mouse transplanted Lewis lung cancer is observed. The method comprises the following steps: c57BL/6 mouse is inoculated with Lewis lung cancer cells, a mouse lung cancer abdominal cavity transplantation tumor animal model is established, a model control group, a mitomycin control group and a mitomycin and traditional Chinese medicine compound preparation high, medium and low dose group are respectively established, the average survival time of animals in each group after administration is observed, and the influence of the compound traditional Chinese medicine preparation and the chemotherapeutic mitomycin on the tumor inhibition effect is evaluated. As a result: the average survival time of the model control group animals is 19.50 +/-3.12 days; the average survival time of the mitomycin control group animals is 23.42 plus or minus 4.65 days; the average survival time of the mice in the high and medium dose groups of the mitomycin and traditional Chinese medicine compound preparation is 27.83 +/-4.33 days and 28.36 +/-4.47 days respectively, and the significant difference is compared with that in the model group. And (4) conclusion: the compound traditional Chinese medicine preparation and the mitomycin are used together, so that the average survival time of mice bearing tumor of Lewis lung cancer can be obviously prolonged, the treatment effect of the chemotherapeutic mitomycin is improved, and the compound traditional Chinese medicine preparation has obvious synergistic attenuation effect.
1. Materials and methods
50 clean-grade C57BL/6 mice were purchased from Beijing Wittingle laboratory animals Co., Ltd, and were male and female for use, weighing 18-22 g. The complete granulated feed for mice is produced by Beijing Olympic experiment animal feed company, drinking water is sterilized tap water, animals freely eat the drinking water during the experiment, the temperature in the laboratory is 21 +/-2 ℃, the humidity is 40-70 percent, and the license number in the laboratory is as follows: SYXK (jin) 2012 and 0001.
Lewis lung cancer cell strain is purchased from Shanghai bioscience research institute of Chinese academy of sciences, and is subcultured in RPMI1640 medium containing 10% fetal bovine serum, and cells in logarithmic growth phase on day 3 after passage are used for experiments.
The traditional Chinese medicine preparation for assisting lung cancer radiotherapy and chemotherapy, which is obtained in the embodiment 1, is prepared into liquid medicine with corresponding content by purified water when in use, and the liquid medicine is administrated by gastric lavage.
Establishment and administration of animal models: taking Lewis lung cancer cells in logarithmic growth phase, and adjusting cell density by PBSIs 1X107The cell suspension of each ml is inoculated in the abdominal cavity of the mouse, the inoculation amount is 0.1ml for each animal, and the inoculated animals are randomly divided into the following 5 groups, each group comprises 10 animals: (1) model group, no drug administration; (2) the mitomycin groups are respectively injected into the abdominal cavity for 1 time on the 1 st day and the 6 th day after the experiment, and the dosage is 1 mg/Kg; (3) the mitomycin and the traditional Chinese medicine compound preparation of the invention are in a high-dose group, except for the administration of the mitomycin, 4g/Kg of the traditional Chinese medicine compound preparation is administered by intragastric administration every day, and the continuous administration is carried out for 10 days; (4) in the mitomycin and the dosage group in the traditional Chinese medicine compound preparation, except for the administration of the mitomycin, the traditional Chinese medicine compound preparation is administered by 2g/Kg per day through intragastric administration and is continuously administered for 10 days; (5) in the mitomycin and traditional Chinese medicine compound preparation low-dose group, except for the administration of the mitomycin, the traditional Chinese medicine compound preparation is administered by 1g/Kg by intragastric administration every day for 10 days continuously.
The observation method comprises the following steps: animals were dosed starting 24 hours after inoculation and animals were weighed once every 3 days and the dose was adjusted according to body weight. Observing and recording the survival time of the animals, wherein the observation time is 60 days, the survival time of the animals with the survival time exceeding 60 days is calculated according to 60 days, respectively counting the average survival days of each group of animals, performing data processing by adopting a t test, comparing the animals with model groups by using medicines, and having significance by taking the P value of less than 0.05.
2. Results
The average survival time of the animals in the model group is 19.50 +/-3.12 days, the survival time of the animals with mitomycin is prolonged to 23.42 +/-4.65 days compared with the animals in the model group, the life prolonging rate is 20.1 percent, but the life prolonging rate is not obviously different from that of the animals in the model group. The average survival time of animals in each dose group of the mitogen-added traditional Chinese medicine is obviously prolonged compared with that in a model group, particularly the life prolonging rates of the animals in the high dose group and the middle dose group reach 42.7 percent and 45.3 percent respectively, and the significant difference is obvious compared with the model group, so that the traditional Chinese medicine compound provided by the invention has a synergistic effect on the curative effect of the chemotherapeutic drugs (see table 1).
TABLE 1 influence of the Compound preparation on the chemotherapy effect of Lewis lung carcinoma model in mice
Group of Number of animals Dosage to be administered Average number of days to live Life extension Rate (%) P value
Model set 10 —————— 19.50±3.12
Mitomycin group 10 1mg/kgX2 silk break 23.42±4.65 20.1 >0.05
Mitosis and traditional Chinese medicine high-dose group 10 1mg/kgX2+ 4g/kgX10 of traditional Chinese medicine 27.83±4.33* 42.7 <0.05
Mitosis and traditional Chinese medicine high-dose group 10 1mg/kgX2+ 2g/kgX10 of traditional Chinese medicine 28.36±4.47* 45.4 <0.05
Mitosis and traditional Chinese medicine high-dose group 10 1mg/kgX2+ 1g/kgX10 of traditional Chinese medicine 25.26±3.28 29.5 >0.05
3. Discussion of the related Art
The experimental result shows that the chemotherapeutic mitomycin has certain treatment effect on the lung cancer of the mice, but the effect of the chemotherapeutic drug is not ideal, and compared with a model group, although the life prolonging rate reaches 20.1%, the effect is not obviously different compared with the model group. After the traditional Chinese medicine compound preparation is added while mitomycin is used, the survival time of animals is obviously prolonged, particularly the life prolonging rates of animals in high and medium dose groups reach 42.7 percent and 45.4 percent respectively, and the traditional Chinese medicine compound preparation has significant difference compared with a model group, shows good effect of inhibiting tumors by cooperating with chemotherapeutic drugs, and shows that the traditional Chinese medicine compound preparation can improve the treatment effect of the tumors and the treatment effect of lung cancer while the traditional Chinese medicine compound preparation is used for tumor chemotherapy.

Claims (3)

1. A traditional Chinese medicine preparation for assisting lung cancer chemotherapy is characterized in that: the traditional Chinese medicine composition comprises, by weight, 9-15 parts of adenophora tetraphylla, 9-15 parts of rabdosia rubescens, 9-15 parts of radix ophiopogonis, 6-9 parts of dandelion, 9-15 parts of radix rehmanniae, 9-15 parts of lalang grass rhizome, 9-15 parts of codonopsis pilosula, 9-15 parts of astragalus membranaceus, 9-15 parts of field thistle, 3-9 parts of sanguisorba officinalis, 3-9 parts of lily, 3-9 parts of rhizoma anemarrhenae, 9-15 parts of purslane, 9-15 parts of Chinese pulsatilla root, 3-9 parts of manyleaf paris rhizome, 9-15 parts of reed rhizome, 9-15 parts of cassia seed, 6-9 parts of semen plantaginis, 9-15 parts of poria cocos, 6-9 parts of mulberry leaf, 6-9 parts of radix bupleuri, 9-15 parts of fructus cannabis, 6-9 parts of cortex lycii radicis, 6-9 parts of radix sophorae flavescentis, 9, 3-9 parts of cynanchum glaucescens, 9-15 parts of celandine, 6-9 parts of ginkgo, 6-9 parts of liquorice, 6-9 parts of ginger and 9-15 parts of Chinese date; adding water with 6-8 times of the total mass of the raw materials into the raw materials, soaking for 20-50 minutes, heating to boil, keeping for 40-70 minutes for first extraction, and collecting the first extract; adding water with the mass 3-5 times of the total mass of the raw materials into the residue, heating and boiling for 20-60 minutes, and collecting the second extracting solution; mixing the two extractive solutions, filtering with gauze, concentrating the filtrate under reduced pressure to obtain soft extract, adding sucrose powder into the soft extract, granulating, drying, sieving, packaging, and sealing; the traditional Chinese medicine preparation is used together with mitomycin to improve the effect of radiotherapy and chemotherapy.
2. The traditional Chinese medicine preparation for assisting lung cancer chemotherapy according to claim 1, which is characterized in that: the traditional Chinese medicine composition is prepared from the following raw materials of 15 parts of adenophora tetraphylla, 15 parts of rabdosia rubescens, 15 parts of radix ophiopogonis, 9 parts of dandelion, 15 parts of radix rehmanniae, 15 parts of lalang grass rhizome, 15 parts of codonopsis pilosula, 15 parts of astragalus membranaceus, 15 parts of herba cephalanoploris, 9 parts of sanguisorba officinalis, 9 parts of lily, 9 parts of rhizoma anemarrhenae, 15 parts of purslane, 15 parts of Chinese pulsatilla root, 9 parts of manyleaf paris rhizome, 15 parts of rhizoma phragmitis, 15 parts of semen cassiae, 9 parts of semen plantaginis, 15 parts of poria cocos, 9 parts of folium mori, 9 parts of radix bupleuri, 15 parts of fructus cannabis, 9 parts of cortex lycii radicis, 9 parts of radix sophorae flavescentis, 15 parts of cistanche, 15 parts of rhizoma atractylodis macrocephal.
3. The use of the Chinese medicinal preparation of claim 1 or 2 in the preparation of a medicament for adjuvant chemotherapy of lung cancer for improving the effect of mitomycin chemotherapy.
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Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
中医药治疗肺癌概况;朱洁等;《湖南中医杂志》;20130228(第02期);第138页第3.2节 *
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肺癌证治三法;周宜强;《中原医刊》;19900831(第04期);第46页第2段 *

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