CN1056064C

CN1056064C - Medicine for curing liver cancer and its making method

Info

Publication number: CN1056064C
Application number: CN93110434A
Authority: CN
Inventors: 潘敏求
Original assignee: Individual
Current assignee: Individual
Priority date: 1993-01-20
Filing date: 1993-01-20
Publication date: 2000-09-06
Anticipated expiration: 2013-01-20
Also published as: CN1075886A

Abstract

The present invention relates to a traditional Chinese medicine for treating liver cancer and a manufacturing method thereof. The traditional Chinese medicine comprises the components of pilose asiabell root, astragalus root, barbat skullcap, turtle shell, tuckahoe, bupleurum root, oyster, peach kernel, cockroache, radix et rhizoma rhei, sappan wood, aristolochiae lignum, curcuma root, white atractylodes rhizome, eaglewood, rhizoma, oriental wormwood, nutagrass flatsedge rhizome, dried orange peel, patriniae radix, pearl barley, rhiizoma dioscoreae from hena of China, safflower, eupatorium, spatholobus stem, medicated leaven, malt, kelp, prism tuber, melia toosendan, paris rhizome, angelica, etc. The traditional Chinese medicine can be made into tablets, pills, glue agents, syrups, etc. The traditional Chinese medicine is superior to a radiotherapy, a chemotherapy and other traditional Chinese medicine preparations. The present invention has a certain effect of inhibiting tumor pain, and can effectively relieve clinical symptoms.

Description

Medicine for curing liver cancer and its making method

The present invention relates to a kind of medicine and manufacture method thereof for the treatment of hepatocarcinoma.

Primary hepatocarcinoma is one of common cancer, has belonged to middle and advanced stage when having the patient of 80-90% to go to a doctor, and survival rate is extremely short, and mortality rate is high.Its treatment is that current medical circle is felt one of stubborn problem most.General X-ray therapy, chemotherapy, the effect that adopts is all undesirable, and serious side effects is arranged, existing treatment by Chinese herbs is a starting point to attack heresy merely all, objective curative effect is still undesirable, China's soup is encouraged the formal plan professor and once reported 54 routine Chinese medicine groups in " Primary Liver Cancer ChinaAcad Bejing Springer-Verlag Berlin 1,989 487 " literary composition, and 61 routine chemotherapy group, 34 routine combination radiotherapy group are controlled back one annual survival rate and are respectively 5.8%, 2.1%, 14.7%.

The object of the present invention is to provide a kind of a kind of Chinese medicine and manufacture method thereof for the treatment of hepatocarcinoma that human body is had no side effect, during this Chinese medicine can prolong effectively, advanced liver cancer patient's survival rate, suppress the development of tumor; Alleviate the clinical symptoms of hepatocarcinoma patient; Improve overall health of patients.

The object of the present invention is achieved like this:

Comprise Radix Codonopsis 2～8 weight %, the Radix Astragali 2～8 weight %, Herba Scutellariae Barbatae 2～8 weight %, Carapax Trionycis 0.5～4 weight %, Poria 2～8 weight %, Radix Bupleuri 1～4 weight %, Concha Ostreae 2～8 weight %, Semen Persicae 1～5 weight %, Eupolyphaga Seu Steleophaga 1～4 weight %, Radix Et Rhizoma Rhei 1～5 weight %, Lignum Sappan 2～8%, Caulis Akebiae 2～8%, Radix Curcumae 2～8 weight %, the Rhizoma Atractylodis Macrocephalae 2～8 weight %, Lignum Aquilariae Resinatum 0.5～4 weight % in this Chinese medicine preparation.

Can also comprise Rhizoma Paridis 0～8 weight %, Herba Artemisiae Scopariae 0～8 weight %, Rhizoma Cyperi 0～8 weight %, Pericarpium Citri Reticulatae 0～8 weight %, Herba Patriniae 0～8 weight %, Semen Coicis 0～8 weight % in this Chinese medicine preparation.

Can also comprise Rhizomadioscoreae 0～8 weight %, Flos Carthami 0～8 weight %, Herba Lycopi 0～8 weight %, Caulis Spatholobi 0～8 weight %, Massa Medicata Fermentata 0～8 weight %, Fructus Hordei Germinatus 0～8 weight %, Thallus Laminariae (Thallus Eckloniae) 0～8 weight %, Rhizoma Paridis 0～8 weight %, Radix Angelicae Sinensis 0～8 weight % in this Chinese medicine preparation.

It is blood stasis, the insufficiency of the spleen and viewpoint of seeing that this prescription has been taken into account hepatocarcinoma, sets upright and combines to attack heresy, and full side is long memorial liver spleen, softening hardness and resolving stasis altogether, the merit of heat-clearing and toxic substances removing.

The preparation method of this medicine is for to make coarse powder with Lignum Aquilariae Resinatum, and half extracts volatile oil, and half is ground into 100 order fine powders, and all the other each medicines decoct with water secondary, and collecting decoction filters, and filter is crossed and is concentrated into relative density 1.1g/cm ³, add the ethanol mix homogeneously.Make and mix liquid measure and contain alcohol and reach 50% and left standstill 24 hours, get supernatant and reclaim ethanol, be condensed into relative density 1.3g/cm ³Above thick paste adds the Lignum Aquilariae Resinatum fine powder, mixes, and oven drying at low temperature is pulverized, alcohol granulation, and oven dry is treated coldly, and spray adds Lignum Aquilariae Resinatum volatile oil, is pressed into tablet or pill, and sugar coating is promptly.

This Chinese medicine can also be made hydration dosage form, syrup preparation, capsule formulation.

Chinese medicine of the present invention is taken and controlled observation through clinical 164 people, and learns by statistics and handle, and proves to be better than X-ray therapy, chemotherapy of using at present and the various Chinese medicine preparation of in the past reporting, and one annual survival rate 328% is significantly higher than other therapies.And proof has certain inhibitory action to tumor, oral tablet 136～150g/l＜g, 10～12 days is 31.74～34.13% to the hepatocarcinoma suppression ratio, tumor body coefficient of stabilization is 78.7%, can effectively alleviate the clinical symptoms of liver cancer patient, its pain relief rate is 76.3%, poor appetite improvement rate is 80.5%, and diarrhoea loose stool remission rate is 66.7%; The animation enhancer reaches 93%.Prove that through toxicity test this medicine can be taken for a long time to human body avirulence, safety.

Embodiment:

Radix Codonopsis 800g, Radix Astragali 1000g, Herba Scutellariae Barbatae 1000g, Semen Persicae 500g, Poria 800g, Eupolyphaga Seu Steleophaga 200g, Radix Bupleuri 400g, Concha Ostreae 600g, Semen Persicae 300g, Carapax Trionycis 200g, Radix Et Rhizoma Rhei 100g, Lignum Sappan 1000g, Caulis Akebiae 1000g, Radix Curcumae 800g, Rhizoma Atractylodis macrocephalae 1000g, Lignum Aquilariae Resinatum 200g, Rhizoma Paridis 800g, Rhizoma Cyperi 800g, Herba Artemisiae Scopariae 800g, Pericarpium Citri Reticulatae 1000g, Herba Patriniae 800g, Radix Angelicae Sinensis 500g.

Lignum Aquilariae Resinatum is made coarse powder, half extracts volatile oil, second half is ground into 100 order fine powders again, and all the other each medicinal decoctings boil secondary, and collecting decoction filters, filtrate is concentrated into relative density 1.1g/cm, add the ethanol mix homogeneously makes mixed liquor contain the alcohol amount to reach 50%, left standstill 24 hours, and got supernatant recovery ethanol and be condensed into relative density 1.3g/cm, above thick paste, add Lignum Aquilariae Resinatum volatile oil, compacting is in blocks, and sugar coating promptly.

Claims

1. a medicine for the treatment of hepatocarcinoma is characterized in that being made by following raw material and percentage by weight: Radix Codonopsis 2-8, Radix Astragali 2-8, Herba Scutellariae Barbatae 2-8, Carapax Trionycis 0.5-4, Poria 2-8, Radix Bupleuri 1-4, Concha Ostreae 2-8, Semen Persicae 1-5, Eupolyphaga Seu Steleophaga 1-4, Radix Et Rhizoma Rhei 1-5, Lignum Sappan 2-8, Caulis Akebiae 2-8, Radix Curcumae 2-8, Rhizoma Atractylodis Macrocephalae 2-8, Lignum Aquilariae Resinatum 0.5-4, Rhizoma Paridis 0-8, Rhizoma Cyperi 0-8, Herba Artemisiae Scopariae 0-8, Pericarpium Citri Reticulatae 0-8, Herba Patriniae 0-8.

2. the manufacture method of medicine according to claim 1, it is characterized in that: except that Lignum Aquilariae Resinatum, all the other each medicinal decoctings boil secondary, and collecting decoction filters, and filtrate is concentrated into relative density 1.1g/cm ³, add the ethanol mix homogeneously, make mixed liquor contain the alcohol amount and reach 50%, left standstill 24 hours, get supernatant and reclaim ethanol, be condensed into relative density 1.3g/cm ³About thick paste, add half fine powder of Lignum Aquilariae Resinatum consumption, mix, oven drying at low temperature is pulverized, alcohol granulation, dries, treats that cold, spray adds second half the volatile oil that extracts in advance of Lignum Aquilariae Resinatum consumption, is compressed to finished product.