CN103285329B - Medicament for treating women dysmenorrhea and preparation method thereof - Google Patents
Medicament for treating women dysmenorrhea and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for treating women dysmenorrhea. The traditional Chinese medicine is prepared from thirteen main drugs and five adjuvants, wherein the main drugs comprise the following components in mass ratio: 6-8 parts of zedoary, 3-6 parts of asarum, 8-12 parts of radix curcumae, 8-12 parts of tuckahoe, 8-12 parts of radix astragali, 12-17 parts of bidentate achyranthes root, 8-10 parts of safflower, 8-15 parts of peach kernel, 8-10 parts of bitter orange, 8-10 parts of ligusticum wallichii, 8-10 parts of radix paeoniae rubra, 12-16 parts of rhizoma cyperi and 12-16 parts of angelica sinensis; the adjuvants comprise the following components in mass ratio: 6-8 parts of fructus evodiae, 6-8 parts of costus root, 10-14 parts of radix bupleuri, 3-5 parts of liquorice and 8-10 parts of pericarpium citri reticulatae viride. A preparation method of the traditional Chinese medicine comprises the following steps of: respectively cleaning the drugs; drying, crushing and sterilizing the drugs; mixing the drugs according to the formula; adding water into the drugs for soaking; heating the drugs through vapor until boiling three times; extracting effective components; filtering the effective components to obtain a liquid medicine, and preparing an extractum; drying the extractum, crushing and grinding into powder; pressing the powder into a tablet or encapsulating the powder to obtain the traditional Chinese medicine. The traditional Chinese medicine is obvious in curative effect and is suitable for treatment of women dysmenorrhea.
Description
Technical field
The present invention is relevant with medicinal preparation, in particular to the medicine for the treatment of dysmenorrhes, also relates to the preparation method of this Chinese medicine.
Background technology
Dysmenorrhea, or be called pain in menstrual period, be one of modal symptom of gynecological.Many women have slight discomfort in menstrual period, but dysmenorrhea refer to menstrual period ache influence normal activity, and need Drug therapy.Periodically pain was common and betided most of menstrual cycle menstrual period.Dysmenorrhea be often angor and with lower back portion pain, feel sick, vomiting, headache or diarrhoea, have a strong impact on healthy and quality of life of women.
A lot of with the Chinese patent application part of Chinese crude drug treatment dysmenorrhes disease, as No. 200410018563.X " a kind of Chinese medicine preparation for the treatment of dysmenorrhes ", number 200510012330.3 " medicine for the treatment of dysmenorrhes and preparation method thereof ", number 200610002243.4 " a kind of medicine for the treatment of dysmenorrhea and preparation method thereof ", 200710151606.5 number " treatment dysmenorrhes, Chinese medicine composition of menoxenia and preparation method thereof ", number 200810139780.2 " preventing and treating the Chinese medicine of dysmenorrhea ", number 200910011460.3 " a kind of medicine for the treatment of dysmenorrhes and preparation method thereof ", number 201010524452.1 " a kind of Chinese medicine for the treatment of dysmenorrhea ", number 201110194699.6 " a kind of Chinese herbs paste and preparation for the treatment of menalgia ", No. 201210237468.3 " menalgia medicated wine " and No. 201310016133.3 " being used for the treatment of the preparation method of Chinese medicine and the external use plaster thereof of menalgia " etc.These patent applications all disclose some Drug therapy dysmenorrhes diseases of utilizing Chinese crude drug to prepare, but its curative effect there is no report.Therefore people are still at exploitation renewal, more effective medicine.
Summary of the invention
Object of the present invention is just to provide a kind of Chinese medicine for the treatment of dysmenorrhes disease, to increase the types of drugs for the treatment of dysmenorrhes disease, enables the health service into people.
Another object of the present invention is to provide the preparation method of this Chinese medicine.
The Chinese medicine for the treatment of dysmenorrhes disease of the present invention is formulated by 13 taste principal agents and 5 taste accessory drugss, and the quality of medicinal material proportioning of principal agent and accessory drugs is:
Principal agent: Rhizoma Curcumae 6～8, Herba Asari 3～6, Radix Curcumae 8～12, Poria 8～12, the Radix Astragali 8～12, Radix Achyranthis Bidentatae 12～17, Flos Carthami 8～10, Semen Persicae 8～15, Fructus Aurantii 8～10, Rhizoma Chuanxiong 8～10, Radix Paeoniae Rubra 8～10, Rhizoma Cyperi 12～16, Radix Angelicae Sinensis 12～16;
Accessory drugs: Fructus Evodiae 6～8, Radix Aucklandiae (Radix Vladimiriae) 6～8, Radix Bupleuri 10～14, Radix Glycyrrhizae 3～5, Pericarpium Citri Reticulatae Viride 8～10.
The optimization formula of this Chinese medicine is:
Principal agent: Rhizoma Curcumae 8, Herba Asari 5, Radix Curcumae 10, Poria 10, the Radix Astragali 10, Radix Achyranthis Bidentatae 16, Flos Carthami 9, Semen Persicae 12, Fructus Aurantii 9, Rhizoma Chuanxiong 9, Radix Paeoniae Rubra 9, Rhizoma Cyperi 14, Radix Angelicae Sinensis 14;
Accessory drugs: Fructus Evodiae 7, Radix Aucklandiae (Radix Vladimiriae) 7, Radix Bupleuri 12, Radix Glycyrrhizae 4, Pericarpium Citri Reticulatae Viride 9.
In above-mentioned principal agent medical material:
rhizoma Curcumaefor zingiberaceous plant Rhizoma Curcumae (
curcuma lzedoaria) rhizome, acrid in the mouth hardship, warm in nature, has circulation of qi promoting, removing blood stasis, removing food stagnancy, pain relieving effect (see the new medical college in Jiangsu compile " Chinese medicine voluminous dictionary " 2450 pages);
herba Asarifor Fructus Aristolochiae plant Herba Asari (
asarum sieboldii) whole herb with root, acrid in the mouth, warm in nature, can dispel the wind, cold expelling, Hang Shui, have one's ideas straightened out (seeing " Chinese medicine voluminous dictionary " 1477 pages);
radix Curcumaefor zingiberaceous plant Rhizoma Curcumae Longae (
curcuma longa) or zingiberaceous plant Rhizoma Curcumae (
curcuma lzedoaria) tuber, acrid in the mouth hardship, cool in nature, has promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs effect (seeing " Chinese medicine voluminous dictionary " 1316 pages);
poriafor Polyporaceae plant Poria (
poria cocos) dry sclerotia, slightly sweet flavor, property is flat, has the effect (seeing " Chinese medicine voluminous dictionary " 1596 pages) of eliminating dampness and diuresis, happy Fructus Alpiniae Oxyphyllae;
the Radix Astragalifor leguminous plant Radix Astragali (
astragalus membranaceus) root, sweet in the mouth, slightly warm in nature, can stomach reinforcing consolidating superficial resistance, inducing diuresis to remove edema, invigorating the spleen and replenishing QI (seeing " Chinese medicine voluminous dictionary " 2036 pages);
radix Achyranthis Bidentatae,for amaranthaceous plant Radix Achyranthis Bidentatae (
achyranthes bidentata) root, sweet in the mouth picric acid, property is flat, has the effect (seeing " Chinese medicine voluminous dictionary " 417 pages) of dissipating blood stasis blood, subduing inflammation;
flos Carthamifor irides Stigma Croci (
crocus sativus) top and the stigma of style, sweet in the mouth, property is flat, can blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens (seeing " Chinese medicine voluminous dictionary " 2671 pages);
semen Persicae, for rosaceous plant Fructus Persicae (
prunus percisa) seed, bitter but sweet flavor, property is flat, has blood stasis removing and clots absorbing, moistens hot-tempered laxation effect (seeing " Chinese medicine voluminous dictionary " 1787 pages);
fructus Aurantii,for rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) (
poncirus trifoliata) mellow fruit nearly, cool in nature, bitter in the mouth is pungent, can dispelling the stagnated QI, and removing food stagnancy (seeing " Chinese medicine voluminous dictionary " 1507 pages);
rhizoma Chuanxiongfor umbrella section plant Rhizoma Chuanxiong (
ligusticum chuanxiong) rhizome, acrid in the mouth, warm in nature, can activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain (seeing " Chinese medicine voluminous dictionary " 220 pages);
radix Paeoniae Rubrafor ranunculaceae plant Radix Paeoniae (
paeonia lactiflora) root, sour in the mouth hardship, cool in nature, can circulation of qi promoting, pain relieving, removing heat from blood, detumescence (seeing " Chinese medicine voluminous dictionary " 1093 pages);
rhizoma Cyperifor sedge dried tuber (
cyperus rotundus) rhizome, the micro-hardship of acrid in the mouth is sweet, property is flat, the resolving depression of regulating the flow of vital energy, pain relieving regulating menstruation (seeing " Chinese medicine voluminous dictionary " 1672 pages);
radix Angelicae Sinensis,for umbelliferae angelica (
angelica sinensis) root, sweet in the mouth is pungent, warm in nature, the effect that has benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation can be controlled menoxenia, headache due to deficiency of blood, dizzy, the numbness of withering (seeing " Chinese medicine voluminous dictionary " 876 pages).
In above-mentioned accessory drugs medical material:
fructus Evodiae,for rutaceae Fructus Evodiae (
evodia retaecarpa) immature fruit, acrid in the mouth hardship, warm in nature, poisonous, have warming middle-JIAO, pain relieving, regulate the flow of vital energy, the effect (seeing " Chinese medicine voluminous dictionary " 1118 pages) of dampness;
radix Aucklandiae (Radix Vladimiriae),be the Radix Aucklandiae, for feverfew Saussurea lappa Clarke (
saussurea lappa) root, acrid in the mouth hardship, warm in nature, can circulation of qi promoting, pain relieving, warming middle-JIAO for easing the stomach (seeing " Chinese medicine voluminous dictionary " 353 pages);
radix Bupleuri, for samphire Radix Bupleuri (
bupleurum chinense) root, bitter in the mouth, cool in nature, have reconciling superficies and interior, soothing the liver yang invigorating effect (seeing " Chinese crude drug voluminous dictionary " 1832 pages);
radix Glycyrrhizae, for glycyrrhizic legume (
glycyrrhiza uralensis) rhizome, sweet in the mouth, property are flat, have and middle emergency, lung moistening, removing toxic substances invigorating the spleen and replenishing QI effect (seeing " Chinese medicine voluminous dictionary " 567 pages);
pericarpium Citri Reticulatae Viride, for rutaceae tangerine produced in fujian province (
citrus tangerina) peel or young fruit, acrid in the mouth hardship, slightly warm in nature, can soothing the liver dispelling the stagnated QI, eliminating stagnation, expectorant (seeing " Chinese medicine voluminous dictionary " 1224 pages).
Above-mentioned medical material should meet the regulation under each medical material item in one of " Chinese Pharmacopoeia " nineteen ninety-five version.
The preparation method of the Chinese medicine of the treatment dysmenorrhes disease that inventor provides is that above-mentioned 13 taste principal agents and 5 taste accessory drugss are cleaned respectively, with hot-air seasoning, is processed into fragment; Use again disinfection by ultraviolet light, after mixing by formula proportion, put into the pond that pottery or copper tank or wooden barrel or cement is built into and add water retting, and pass into steam heated to boiling 3 times, and 1～2 hour for the first time, 0.5～1 hour for the second time, 0.5 hour for the third time, so far wherein active ingredient proposed substantially; After filtering, medicinal liquid is made extractum; Fire drying in using again, pulverizes, grinds to form 60 order powder; Finally pharmaceutical technology routinely, is pressed into tablet or incapsulates, and every 1g or every 1g, obtain tablet or capsule.Product should meet the requirement in one of " Chinese Pharmacopoeia " nineteen ninety-five version.
The above-mentioned pharmaceutical technology that is pressed into tablet comprises: 1. the 60 order powder that make are added to adjuvant, main adjuvant is adhesive modified starch, mix homogeneously; 2. in mixed powder, add water as wetting agent, make soft material; 3. soft material extruding is sieved, granulation; 4. granule is through super-dry, make its moisture be applicable to and evenly, grain graininess is suitable; 5. dried particles, through inspection, confirms to meet the requirement of tablet; 6. extrude tablet with punching type or rotary tablet machine, what be up to the standards is finished product.
The pharmaceutical technology of above-mentioned capsule comprises: 1. prepare or buy the capsulae vacuus taking gelatin as primary raw material; 2. the 60 order powder that make are crossed to sieve No. 6, the fine powder obtaining is for subsequent use; 3. enter soft capsule with the artificial medicated powder of loading, or pack medicated powder into automatic filling machine; 4. the effective ingredient to medicated powder and quality are tested, and the qualified rear glue with gelatin, in the sealing of capsule capping place, obtains finished product.
Inventor points out: this Chinese medicine also can be prepared into any conventional peroral dosage form by conventional method of Chinese medicinal.No matter which kind of dosage form, all must deposit according to the relevant regulations of drug stock control.
The Chinese medicine using method for the treatment of dysmenorrhes disease of the present invention is oral, warm water delivery service, every day 2 times, each 4～5/sheet.
The Chinese medicine for the treatment of dysmenorrhes disease of the present invention is tested application clinical, and treatment dysmenorrhes disease patient 17 examples, all achieve good results.Model case has:
Case one: Zhou great Mei, female, 27 years old; Graduate from Beijing institute of foreign languages, the work of Beijing Yi Jia foreign enterprise; Because of menstrual period pain cause shock, be repeatedly sent to hospital doctor by " 120 " ambulance and examine rescue, through Beijing, Shanghai, West China Duo Jia hospital treatment all to no effect after, dismiss the work of foreign enterprise's high salary, go back to native place Bijie; Readme dysmenorrhea is had a surplus for 10 years, each menstrual period, first or second fetus, the generation of the bad phenomenon such as just whole body splits pain, and numb with whole body, cramp; Start to take medicine of the present invention when first three day of menstrual phase, until menstrual onset, pain subtracts greatly, and numb, cramp phenomenon originally disappear, and patient sends a telegram here and says gratefully, and it is large painful that she has broken away from one over 10 years finally, and perhaps this prescription has changed her all one's life.There is not untoward reaction menstrual period in second month yet.Telephone number: 13985352698.
Case two: Nie Yumei, female, 35 years old; Menstrual period lower abdomen pain for many years, 2009 start to increase the weight of, every menstrual phase first day starts hypogastralgia, when serious, white, the cold sweat of face deep blue all over the body and with nauseating, dizzy etc., must can be alleviated with analgesic, after 2010, also difficult alleviating pain of use analgesic; After take this medicine, menstruation come within first 5 days, starts to take, dysmenorrhea subtracts; Honor doctor's advice, starts to take according to top from next menstruation, and dysmenorrhea all disappears afterwards, not recurrence.
Case three: Li Yuanguang, female, 41 years old, dysmenorrhea 13 years, 14 the beginning of the year tide, about 30 days cycles, in 5 to 6 days menstrual period, menstruation first day is stomachache just, about 2 to 3 days, generally can insist, within 19 years old, start symptom aggravation, sometimes severe pain bed, and with the sensation of lumbago, once took multiple Chinese medicine and western medicine, DeGrain, after being introduced, takes medicine of the present invention and serve on one month with regard to pain relieving in second day, second month menstrual phase, without pain, now had a surplus for 2 years, and dysmenorrhea phenomenon does not recur.
The Chinese medicinal material for the treatment of dysmenorrhes disease of the present invention is easy to get, and easy to process, curative effect is obvious, is applicable to treat the patient of dysmenorrhes disease.
Detailed description of the invention
embodiment 1chinese medicine according to the following step preparation treatment dysmenorrhes disease:
Above-mentioned 13 taste principal agents and 5 taste accessory drugs medical materials are cleaned respectively, with hot-air seasoning, be processed into fragment; Use again disinfection by ultraviolet light.Then get principal agent: Rhizoma Curcumae 8g, Herba Asari 5g, Radix Curcumae 10g, Poria 10g, Radix Astragali 10g, Radix Achyranthis Bidentatae 16g, Flos Carthami 9g, Semen Persicae 12g, Fructus Aurantii 9g, Rhizoma Chuanxiong 9g, Radix Paeoniae Rubra 9g, Rhizoma Cyperi 14g, Radix Angelicae Sinensis 14g; Get again accessory drugs: Fructus Evodiae 7g, Radix Aucklandiae (Radix Vladimiriae) 7g, Radix Bupleuri 12g, Radix Glycyrrhizae 4g, Pericarpium Citri Reticulatae Viride 9g; After mixing, put into wooden barrel and add water retting, and pass into steam heated 3 times to boiling, 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, so far wherein active ingredient proposed substantially; After filtering, medicinal liquid is made extractum; Fire drying in using again, pulverizes, grinds to form 60 order powder; Finally pharmaceutical technology routinely, is pressed into tablet, and every 1g, obtains tablet product.
embodiment 2
Preparation process is with embodiment 1.Grind to form 60 object drug powders, finally pharmaceutical technology routinely, incapsulates, and every 1g, obtains capsule product.
Claims (3)
1. treat a Chinese medicine for dysmenorrhes disease, it is characterized in that this Chinese medicine is formulated by 13 taste principal agents and 5 taste accessory drugss, the quality of medicinal material proportioning of principal agent and accessory drugs is:
Principal agent: Rhizoma Curcumae 6～8, Herba Asari 3～6, Radix Curcumae 8～12, Poria 8～12, the Radix Astragali 8～12, Radix Achyranthis Bidentatae 12～17, Flos Carthami 8～10, Semen Persicae 8～15, Fructus Aurantii 8～10, Rhizoma Chuanxiong 8～10, Radix Paeoniae Rubra 8～10, Rhizoma Cyperi 12～16, Radix Angelicae Sinensis 12～16;
Accessory drugs: Fructus Evodiae 6～8, Radix Aucklandiae (Radix Vladimiriae) 6～8, Radix Bupleuri 10～14, Radix Glycyrrhizae 3～5, Pericarpium Citri Reticulatae Viride 8～10.
2. Chinese medicine as claimed in claim 1, is characterized in that this Chinese medicine is formulated by 13 taste principal agents and 5 taste accessory drugss, and the quality of medicinal material proportioning of principal agent and accessory drugs is:
Principal agent: Rhizoma Curcumae 8, Herba Asari 5, Radix Curcumae 10, Poria 10, the Radix Astragali 10, Radix Achyranthis Bidentatae 16, Flos Carthami 9, Semen Persicae 12, Fructus Aurantii 9, Rhizoma Chuanxiong 9, Radix Paeoniae Rubra 9, Rhizoma Cyperi 14, Radix Angelicae Sinensis 14;
Accessory drugs: Fructus Evodiae 7, Radix Aucklandiae (Radix Vladimiriae) 7, Radix Bupleuri 12, Radix Glycyrrhizae 4, Pericarpium Citri Reticulatae Viride 9.
3. the method for the Chinese medicine of the treatment dysmenorrhes disease of one of preparation claim 1 or 2, is characterized in that above-mentioned 13 taste principal agents and 5 taste accessory drugss to clean respectively, with hot-air seasoning, is processed into fragment; Use again disinfection by ultraviolet light, after mixing by formula proportion, put into the pond that pottery or copper tank or wooden barrel or cement is built into and add water retting, and pass into steam heated to boiling 3 times, and 1～2 hour for the first time, 0.5～1 hour for the second time, 0.5 hour for the third time, so far wherein active ingredient proposed substantially; After filtering, medicinal liquid is made extractum; Fire drying in using again, pulverizes, grinds to form 60 order powder; Finally pharmaceutical technology routinely, is pressed into tablet or incapsulates, and every 1g or every 1g, obtain tablet or capsule.
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104664352A (en) * | 2013-11-30 | 2015-06-03 | 刘志方 | Nutritional tablet for treating dysmenorrhea |
| CN104474521B (en) * | 2014-12-30 | 2017-08-11 | 兰州古驰生物科技有限公司 | A kind of Chinese medicine preparation for being used to recuperate under medical treatment dysmenorrhoea |
| CN106266950A (en) * | 2016-08-30 | 2017-01-04 | 高华勇 | Health care milk tea for the treatment of menalgia and preparation method thereof |
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Non-Patent Citations (2)
| Title |
|---|
| 原发性痛经的中药临床应用规律分析;魏爱平等;《北京中医药大学学报(中医临床版)》;20110131;第18卷(第01期);24-26 * |
| 魏爱平等.原发性痛经的中药临床应用规律分析.《北京中医药大学学报(中医临床版)》.2011,第18卷(第01期),24-26. |
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