CN103285128B - Traditional Chinese medicine for treating bronchial asthma and preparation method thereof - Google Patents
Traditional Chinese medicine for treating bronchial asthma and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for treating bronchial asthma. The traditional Chinese medicine is prepared from the following medicines in mass fraction: 6 to 10 parts of ephedra, 3 to 6 parts of asarum sieboldii, 20 to 26 parts of gypsum, 4 to 8 parts of cassia twig, 10 to 12 parts of dried tangerine peel, 10 to 12 parts of semen lepidii, 20 to 30 parts of astragalus membranaceus, 20 to 30 parts of cortex mori radicis, 10 to 14 parts of fructus aurantii, 4 to 7 parts of radix aucklandiae, 10 to 14 parts of radix bupleuri, 10 to 14 parts of folium mori, 10 to 14 parts of honeysuckle, 8 to 12 parts of flos farfarae, and 8 to 12 parts of folium eriobotryae, wherein the ephedra is fried in advance, and the gypsum is raw gypsum. The preparation method comprises the following steps of: preparing each traditional Chinese medicine according to a prescription, wherein the ephedra is fried in advance; drying all the medicines and crushing into pieces; sterilizing; repeatedly decocting with water at three times; filtering and preparing into an extract; drying with medium heat; crushing and grinding into powder; finally pressing into troches or filling into capsules to obtain the finished product. The traditional Chinese medicine is fast to become effect, reliable, safe to use and suitable for being used for treating a patient suffering from bronchial asthma.
Description
Technical field
The present invention relates to pharmaceutical composition, in particular to the medicine for the treatment of bronchial asthma taking Chinese crude drug as preparation of raw material.
Background technology
Bronchial asthma (abbreviation asthma) is a kind of commonly encountered diseases, frequently-occurring disease.At present, global asthmatic patient about 300,000,000 people, Chinese patients with asthma about 3,000 ten thousand.Asthma affects the able-bodied important diseases of people.Treatment not in time, lack of standardization, asthma may be fatal.The risk factor of asthma comprises host factor (inherited genetic factors) and environmental factors two aspects, but most of asthmatic patient belongs to allergic constitution.The clinical manifestation of asthma is divided into acute attack stage, chronic sustained phase and clinical relieving period, acute attack, may be fatal when giving treatment to not in time.Doctor trained in Western medicine adopts and controls medicine and cushion treatment.
China is in treatment bronchial asthma for thousands of years, have accumulated rich experience.In recent years, there is the Chinese medicine formula application of many treatment bronchial asthma patent of invention, such as No. 200510114645.9 " a kind of compound Chinese medicinal preparation for the treatment of asthma and preparation method thereof ", number 200710116197.5 " a kind of Chinese medicine being used for the treatment of bronchial asthma for oral administration ", number 200910231514.7 " a kind of Chinese medicinal ointment for the treatment of bronchial asthma ", number 201010221755.6 " a kind of Chinese medicine composition for the treatment of bronchial asthma ", number 201110372302.8 " a kind of Chinese medicine for the treatment of bronchial asthma ", number 201210409375.4 " a kind of Chinese medicine decoction for the treatment of bronchial asthma and preparation method thereof " etc.The formula of above-mentioned patent application is different, and therapeutic effect is also not quite similar.In medical practice, in general, the traditional Chinese medical science cure the disease effective, substantially have no side effect.Therefore people continue to excavate Chinese material medicine resource, develop more efficiently medicine.
Summary of the invention
Object of the present invention is just to provide a kind of Chinese medicine for the treatment of bronchial asthma, increases the types of drugs for the treatment of bronchial asthma, makes patient remove the puzzlement of asthma, get well.
Another object of the present invention is to provide the preparation method of this Chinese medicine.
The Chinese medicine for the treatment of bronchial asthma of the present invention is formulated by following medical material, and their quality proportioning is:
Herba Ephedrae 6 ~ 10, Herba Asari 3 ~ 6, Gypsum Fibrosum 20 ~ 26, Ramulus Cinnamomi 4 ~ 8, Exocarpium Citri Rubrum 10 ~ 12, Semen Lepidii (Semen Descurainiae) 10 ~ 12, the Radix Astragali 20 ~ 30, Cortex Mori 20 ~ 30, Fructus Aurantii 10 ~ 14, the Radix Aucklandiae 4 ~ 7, Radix Bupleuri 10 ~ 14, Folium Mori 10 ~ 14, Flos Lonicerae 10 ~ 14, Flos Farfarae 8 ~ 12, Folium Eriobotryae 8 ~ 12; Described Herba Ephedrae must parch in advance, and described Gypsum Fibrosum is raw to be used.
The optimization formula of this Chinese medicine is:
Herba Ephedrae 8, Herba Asari 5, Gypsum Fibrosum 22, Ramulus Cinnamomi 6, Exocarpium Citri Rubrum 11, Semen Lepidii (Semen Descurainiae) 11, the Radix Astragali 25, Cortex Mori 25, Fructus Aurantii 12, the Radix Aucklandiae 6, Radix Bupleuri 12, Folium Mori 12, Flos Lonicerae 12, Flos Farfarae 10, Folium Eriobotryae 10; Described Herba Ephedrae must parch in advance, and described Gypsum Fibrosum is raw to be used.
In above-mentioned Chinese medicine,
herba Ephedraefor Ephedraceae plant plait Herba Ephedrae (
ephedra sinica) herb stem, acrid in the mouth is bitter, warm in nature, can diaphoresis, relievings asthma, diuretic (compiling " Chinese medicine voluminous dictionary " 2221 pages see the new medical college in Jiangsu);
herba Asarifor Fructus Aristolochiae plant Herba Asari (
asarum sieboldii) whole herb with root, acrid in the mouth, warm in nature, can dispel the wind, cold expelling, Hang Shui, have one's ideas straightened out (see " Chinese medicine voluminous dictionary " 1477 pages);
gypsum Fibrosum, for Sulfates mineral gypsum (
cypsum) Ore, acrid-sweet flavor, cold in nature, expelling pathogenic factors from muscles for clearing heat, relieving restlessness is quenched the thirst (see " Chinese medicine voluminous dictionary " 592 pages);
ramulus Cinnamomifor canella Cortex Cinnamomi (
cinnamomum cassia) twig, acrid-sweet flavor, warm in nature, can diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation (see " Chinese medicine voluminous dictionary " 1771 pages);
exocarpium Citri Rubrumfor rutaceae tangerine produced in fujian province (
citrum tangerina) or Zhu's Fructus Citri tangerinae (
citrum erythrosa) outer RED sector, acrid in the mouth is bitter, warm in nature, can expectorant, promoting the circulation of QI, alleviating distention in middle-JIAO, eliminating stagnation (see " Chinese medicine voluminous dictionary " 2639 pages);
semen Lepidii (Semen Descurainiae)for crucifer Lepidium sativum L. (
lepidium apetalum) seed, acrid in the mouth is bitter, cold in nature, has the effect (see " Chinese medicine voluminous dictionary " 2319 pages) of therapeutic method to keep the adverse QI flowing downwards row water;
the Radix Astragalifor leguminous plant Radix Astragali (
astragalus membranaceus) root, sweet in the mouth, slightly warm in nature, can stomach reinforcing consolidating superficial resistance, inducing diuresis to remove edema, invigorating the spleen and replenishing QI (see " Chinese medicine voluminous dictionary " 2036 pages);
cortex Morifor moraceae plants Mulberry (
morus alba) removing cork root bark, sweet in the mouth, cold in nature, have eliminating pathogen from the lung for relieving asthma, the effect (see " Chinese medicine voluminous dictionary " 1968 pages) of line water detumescence;
fructus Aurantiifor rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) (
poncirus trifoliata) nearly mellow fruit, cool in nature, bitter in the mouth is pungent, can dispelling the stagnated QI, removing food stagnancy (see " Chinese medicine voluminous dictionary " 1507 pages);
the Radix Aucklandiaefor feverfew Saussurea lappa Clarke (
saussurea lappa) root, acrid in the mouth is bitter, warm in nature, can circulation of qi promoting, pain relieving, warming middle-JIAO for easing the stomach (see " Chinese medicine voluminous dictionary " 353 pages);
radix Bupleurifor samphire Radix Bupleuri (
bupleurum chinense) root, bitter in the mouth, cool in nature, have reconciling superficies and interior, soothing the liver yang invigorating effect (see " Chinese crude drug voluminous dictionary " 1832 pages);
folium Morifor moraceae plants Mulberry (
morus alba) leaf, bitter but sweet flavor, cold in nature, have expelling wind and clearing away heat, cooling blood for improving eyesight effect (see " Chinese medicine voluminous dictionary " 1963 pages);
flos Loniceraefor caprifoliaceae plant Radix Ophiopogonis (
lonicera japonica) alabastrum, sweet in the mouth, cold in nature, can heat-clearing and toxic substances removing (see " Chinese medicine voluminous dictionary " 1403 pages);
flos Farfaraefor feverfew coltsfoot (
tussilago farfara) alabastrum, acrid in the mouth, warm in nature, can nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing (see " Chinese medicine voluminous dictionary " 2301 pages);
folium Eriobotryaefor rosaceous plant Folium Eriobotryae (
eriobotrya japonica) leaf, bitter in the mouth, cool in nature, have the effect (see " Chinese medicine voluminous dictionary " 1248 pages) of lung heat clearing stomach function regulating, lowering the adverse-rising QI to resolve phlegm.
Above-mentioned medical material should meet the regulation in " Chinese Pharmacopoeia " nineteen ninety-five version one under each medical material item.
The preparation method of the Chinese medicine for the treatment of bronchial asthma of the present invention is that wherein, Herba Ephedrae was processed in advance by each taste Chinese medicine in formula for medicine; Again above-mentioned whole medicine is dried, in flakes broken, then use disinfection by ultraviolet light, add water decoction repeatedly 3 times to put into pottery or copper tank or copper utensil (should not with iron pan), 1 ~ 2 hour first time, second time 0.5 ~ 1 hour, 0.5 hour third time, filters and makes extractum; Fire drying in using again, pulverizes, grinds to form 60 order powder; Last pharmaceutical technology routinely, is pressed into tablet or incapsulates, and every 1g or every sheet 1g, obtains tablet or capsule.Product should meet the requirement in " Chinese Pharmacopoeia " nineteen ninety-five version one.
The above-mentioned pharmaceutical technology being pressed into tablet comprises: 1. 60 obtained order powder are added adjuvant, main adjuvant is adhesive modified starch, mix homogeneously; 2. add water in mixed powder as wetting agent, make soft material; 3. soft material extruding is sieved, make granule; 4. granule is through super-dry, make its moisture be applicable to and evenly, grain graininess is suitable; 5. dried particles is through inspection, confirms the requirement meeting tablet; 6. extrude tablet with Chong Yashi or rotary tablet machine, what be up to the standards is finished product.
The pharmaceutical technology of above-mentioned capsule comprises: 1. preparing or buying with gelatin is the capsulae vacuus of primary raw material; 2. 60 obtained order powder are crossed No. 6 sieves, the fine powder obtained is for subsequent use; 3. enter soft capsule with artificial medicated powder of loading, or load medicated powder with automatic filling machine; 4. test to the effective ingredient of medicated powder and quality, the glue of qualified rear gelatin, in the sealing of capsule capping place, obtains finished product.
Inventor points out: this Chinese medicine also can be prepared into any one by conventional method of Chinese medicinal and commonly use peroral dosage form.No matter which kind of dosage form, all must deposit according to the relevant regulations of drug stock control.
The usage of Chinese materia medica for the treatment of bronchial asthma of the present invention is oral, warm water delivery service, every day 2 times, each 4-5 grain.Also dose can be added and subtracted as one sees fit according to the state of an illness.
Result in clinical application shows, this Chinese Herbs is remarkable, takes a few hours to get final product cough-relieving, control and breathe heavily; Make special effect to bronochitic, effective percentage is more than 85%
Inventor successfully cured many Bronchial Asthmas, and wherein more typical case has:
Case one: You Zhengrong, female, 70 years old.Patient starts to suffer from bronchial asthma for 1975, for a long time with ephedrine Zhichuan, after abusing and selling due to state control ephedrine, just use clenbuterol cough-relieving Zhichuan instead.Over nearly 5 years, because the age increases, clenbuterol has been difficult to solve bronchial asthma, and take medicine of the present invention after 1 month through changing into, asthma obviously alleviates, and serve on 4 months asthma basic controlling, health is obviously got well.
Case two: mother the present inventor Zhu Zhengying, female, 78 years old.Once suffered from bronchitis=asthma for many years, life-time service hormone drug or aminophylline are alleviated, but medicine shows effect again after stopping.Started to take medicine of the present invention two months in 2006, asthma obviously alleviates, and serve on half a year, and symptom controls completely.
Case three: Gong Xuhua, man, 14 years old, Cha He people from town, Bijie City, Guizhou Province.Pant because patient often coughs, rale in pharynx, dyspnea, the vexed pain of fullness in the chest, thirsty vexed, be bronchial asthma through hospital diagnosis.Take medicine of the present invention after 5 days, breathe smooth and easy, serve on 20 days, condition, follow up a case by regular visits to after half a year, do not recur.
Chinese medicine of the present invention, rapidly, reliably, use safety, is applicable to treat Bronchial Asthmas curative effect.
Detailed description of the invention
embodiment 1
By each taste Chinese medicine in formula for medicine, wherein, Herba Ephedrae was processed in advance; Again above-mentioned whole medicine is dried, in flakes broken, then use disinfection by ultraviolet light, put into copper tank and add water and repeatedly decoct 3 times, 2 hours first times, second time 1 hour, 0.5 hour third time, filters and makes extractum; Fire drying in using again, pulverizes, grinds to form 60 order powder; Last pharmaceutical technology routinely, be pressed into tablet, every sheet 1g, obtains tablet.
embodiment 2
Preparation process is with embodiment 1.Grind to form 60 object drug powders, finally pharmaceutical technology routinely, incapsulate, every 1g, obtain capsule product.
Claims (2)
1. treat a Chinese medicine for bronchial asthma, it is characterized in that this Chinese medicine is formulated by following medical material, their quality proportioning is:
Herba Ephedrae 6 ~ 10, Herba Asari 3 ~ 6, Gypsum Fibrosum 20 ~ 26, Ramulus Cinnamomi 4 ~ 8, Exocarpium Citri Rubrum 10 ~ 12, Semen Lepidii (Semen Descurainiae) 10 ~ 12, the Radix Astragali 20 ~ 30, Cortex Mori 20 ~ 30, Fructus Aurantii 10 ~ 14, the Radix Aucklandiae 4 ~ 7, Radix Bupleuri 10 ~ 14, Folium Mori 10 ~ 14, Flos Lonicerae 10 ~ 14, Flos Farfarae 8 ~ 12, Folium Eriobotryae 8 ~ 12; Described Herba Ephedrae must parch in advance, and described Gypsum Fibrosum is raw to be used.
2. according to Chinese medicine according to claim 1, it is characterized in that this Chinese medicine is formulated by following medical material, their quality proportioning is:
Herba Ephedrae 8, Herba Asari 5, Gypsum Fibrosum 22, Ramulus Cinnamomi 6, Exocarpium Citri Rubrum 11, Semen Lepidii (Semen Descurainiae) 11, the Radix Astragali 25, Cortex Mori 25, Fructus Aurantii 12, the Radix Aucklandiae 6, Radix Bupleuri 12, Folium Mori 12, Flos Lonicerae 12, Flos Farfarae 10, Folium Eriobotryae 10; Described Herba Ephedrae must parch in advance, and described Gypsum Fibrosum is raw to be used.
3. prepare the method for one of claim 1 and 2 described Chinese medicine, it is characterized in that wherein, Herba Ephedrae was processed in advance by each taste Chinese medicine in formula for medicine; Again above-mentioned whole medicine is dried, in flakes broken, then use disinfection by ultraviolet light, put into pottery or copper tank or copper utensil and add water and repeatedly decoct 3 times, 1 ~ 2 hour first time, second time 0.5 ~ 1 hour, 0.5 hour third time, filters and makes extractum; Fire drying in using again, pulverizes, grinds to form 60 order powder; Last pharmaceutical technology routinely, is pressed into tablet or incapsulates, and every 1g or every sheet 1g, obtains tablet or capsule.
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| CN103566157B (en) * | 2013-09-30 | 2016-05-11 | 尹雯雯 | A kind of Chinese medicine composition for the treatment of asthma |
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| KR101805004B1 (en) * | 2010-04-06 | 2017-12-07 | (주)아모레퍼시픽 | Fermentation method using medicinal leaf and skin external composition containing fermented extract by the method |
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