CN100431570C - Medicine for treating idiopathy thrombocytopenia peliosis - Google Patents
Medicine for treating idiopathy thrombocytopenia peliosis Download PDFInfo
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- CN100431570C CN100431570C CNB2005100421957A CN200510042195A CN100431570C CN 100431570 C CN100431570 C CN 100431570C CN B2005100421957 A CNB2005100421957 A CN B2005100421957A CN 200510042195 A CN200510042195 A CN 200510042195A CN 100431570 C CN100431570 C CN 100431570C
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Abstract
The present invention discloses a medicine for treating primary purpura hemorrhagica, which is mainly composed of the following raw materials: 30 to 60 portions of astragalus root, 16 to 48 portions of figwort root, 16 to 48 portions of rehmannia root, 20 to 60 portions of herba agrimoniae, 16 to 48 portions of callicarpa herb, 16 to 48 portions of turtle shell, 20 to 60 portions of angelica, 40 to 100 portions of Chinese date, 20 to 60 portions of largehead atractylodes rhizome, 8 to 24 portions of largetrifoliolious bugbane rhizome and 10 to 30 portions of purple gromwell root. The whole formula has strict compatibility so as to realize coordination between QI and blood, the quantity of blood platelets in peripheral blood can be obviously increased and achieve a normal level, and all the disease symptoms are eliminated to restore health.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of the idiopathic thrombocytopenic purpura disease, relate in particular to a kind of Chinese medicine for the treatment of the idiopathic thrombocytopenic purpura disease.
Background technology
Idiopathic thrombocytopenic purpura (ITP) is a kind of more common hematostaxis disease that causes owing to thrombocytopenia, its Clinical symptoms is the thrombocytopenia in the peripheral blood, megalokaryocyte compensatory hypertrophy in platelet survival time shortening and the bone marrow, skin, mucosa, joint or visceral hemorrhage phenomenon.Pilosity is born in school age child and women.Think that at present its cause of disease and pathogeny thereof are relevant with autoimmune, so this disease also can be described as immunologic thrombocytopenic purpura.Its clinical manifestation is similar to the traditional Chinese medical science " purpura ", diseases such as " hematohidrosis " and " speckle poison ", but above-mentioned all diseases all can belong to the category of " blood disorder ".
The clinical treatment Western medicine of ITP does not still have specific medicament at present, generally with adrenocortical hormone (abbreviation hormone), splenectomy immunosuppressant etc.But because above-mentioned Therapeutic Method all has commonplace toxicity.Dosage is big, and financial burden is heavier, in case drug withdrawal, relapse rate is high.
The objective of the invention is at above-mentioned situation, provide a kind of dosage few, have no side effect, moderate cost, the medicine of the treatment ITP disease of convenient oral.
The present invention treats the Chinese medicinal capsule of idiopathic thrombocytopenic purpura, be to adopt the natural Chinese medicinal herb material to do raw material, through compbined test acquisition repeatedly, its raw material prescription: by the Radix Astragali, Rhizoma Cimicifugae, Radix Arnebiae (Radix Lithospermi), four kinds of medical materials of Fructus Jujubae is basic prescription, Radix Astragali 30-60 part, Rhizoma Cimicifugae 8-24 part, Radix Arnebiae (Radix Lithospermi) 10-30 part, Fructus Jujubae 40-100 mainly can treat with the lung deficiency of spleen-YANG, and sinking of QI of middle-JIAO is the ITP patient of primary symptom, but QI invigorating, ascending the clear and descending the turbid, spleen reinforcing is good for the stomach;
Add Radix Scrophulariae 6-48 part, two kinds of medical materials of Radix Rehmanniae 6-48 part, applicable to the stagnant heat fire-transformation, heat is compeled the ITP patient of blood preposterous type, but heat clearing away, removing heat from blood.
Adding Herba Agrimoniae 20-60 part, Folium Callicarpae Formosanae 16-48 part can be strengthened above-mentioned ITP patient's hemostasia effect on the basis of aforementioned six kinds of crude drug, reduce the bleeding of subcutaneous or internal organs.Favourable stable disease.
On the basis of aforementioned eight kinds of crude drug, add Carapax Trionycis 16-48 part again, Radix Angelicae Sinensis 20-60 part.Strengthen the nourishing YIN for suppressing the hyperactive YANG of this preparation, the effect of enriching blood, promotion ITP patient's hemopoietic lift slab function.
Add the Rhizoma Atractylodis Macrocephalae again on the basis of aforementioned ten kinds of crude drug, can strengthen spleen and stomach function, The spleen governs the blood can increase ITP patient's stable disease, improves curative effect, reduces relapse rate, to reach basic treatment.
Qi as the commander of blood, ten thousand diseases all are born in gas, and the stagnation of QI is stasis then, and the capable then blood of gas is capable, and the living then blood of gas is given birth to the absurd row of hot forcing blood.Radix Astragali QI invigorating, Radix Scrophulariae, Radix Rehmanniae clearing away heat from blood, pathogenic fire reducing.The Rhizoma Cimicifugae ascending the clear and descending the turbid; Herba Agrimoniae, Folium Callicarpae Formosanae hemostasis.The Radix Arnebiae (Radix Lithospermi) speckle removing.The Carapax Trionycis calming down the floating YANG for astringing YIN.Radix Angelicae Sinensis strengthens blood nourishing function.Stomach is mended in Rhizoma Atractylodis Macrocephalae spleen invigorating.Full side's compatibility is rigorous, is in harmonious proportion to reach QI and blood, and all disease knowing are removed, and get well.
Constitutive material medicine content range can be: Radix Astragali 30-60 part, Radix Scrophulariae 16-48 part, Radix Rehmanniae 16-48 part, Herba Agrimoniae 20-60 part, Folium Callicarpae Formosanae 16-48 part, Carapax Trionycis 16-48 part, Radix Angelicae Sinensis 20-60 part, Fructus Jujubae 40-100 part, Rhizoma Atractylodis Macrocephalae 20-60 part, Rhizoma Cimicifugae 8-24 part, Radix Arnebiae (Radix Lithospermi) 10-30 part.
Raw medicinal material prescription of the present invention is based on following pharmacology apolegamy: the Pharmacopoeia of the People's Republic of China carries: the Radix Astragali, the sweet in the mouth temperature is gone into the lung spleen channel, function invigorating QI to consolidate the body surface resistance, diuresis poison holding, the thin Huang of blood deficiency.
Radix Scrophulariae, nature and flavor are sweet, bitter, salty, are slightly cold.Return spleen, stomach, kidney channel, function removing heat from blood YIN nourishing, eliminating fire and detoxication.Be used for consumption of YIN caused by febrile disease, maculae caused by violent heat pathogen.
Radix Rehmanniae, sweet, bitter, cold.GUIXIN, liver, kidney channel.Function cures mainly: clearing away heat and promoting production of body fluid, and removing heat from blood, the speckle dermexanthesis is sent out in hemostasis, spits blood epistaxis.
Herba Agrimoniae is bitter, puckery, flat.GUIXIN, Liver Channel.The function astringing to arrest bleeding, detoxifcation.Be used for hemoptysis, spit blood metrostaxis.
Carapax Trionycis, salty, be slightly cold.Return liver, kidney channel.Nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving is brought down a fever to remove and is steamed.Be used for fever due to yin deficiency, the consumptive fever hectic fever due to YIN-deficiency.
Radix Angelicae Sinensis, nature and flavor are sweet, hot, warm.Return liver, the heart, spleen channel.Function is enriched blood and is invigorated blood circulation.Be used for blood deficiency and yellow complexion.
Fructus Jujubae, nature and flavor are sweet, warm.Return spleen, stomach warp.Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.
The Rhizoma Atractylodis Macrocephalae, nature and flavor hardship, sweet, warm.Return spleen, stomach warp.The function invigorating the spleen and benefiting QI.
Radix Arnebiae (Radix Lithospermi), nature and flavor are sweet, salty, cold.GUIXIN, Liver Channel.The function removing heat from blood, invigorate blood circulation the detoxifcation rash.Be used for the heat in blood poison and contain, macule is purple black.
Rhizoma Cimicifugae, nature and flavor suffering, little sweet is slightly cold.Heat-clearing and toxic substances removing, the elevate a turnable ladder yang-energy.Be used for YANG toxin syndrome and send out speckle.
Folium Callicarpae Formosanae, nature and flavor are bitter flat, and function is invigorated blood circulation, hemostasis, heat extraction, detoxifcation.Control haematemesis, spitting of blood, epistaxis is had blood in stool, metrorrhagia, wound hemorrhage etc.
The preparation method that the present invention treats the Chinese medicinal capsule of ITP is: each composition in the component is determined a concrete volume value in amount ranges separately, weigh the consumption number of each crude drug then, produce extracting solution through decocting in water, concentrate spraying, encapsulated forming.
Concrete technological process is as follows:
1, decocting in water (producing extracting solution): the crude drug that will be equipped with is in proportion sent into the multi-function extractor decocting in water, obtains extracting solution.
2, concentrate: extracting solution is sent into the centrifugal thin-film thickener concentrate;
3, spraying: send into duster again and dust, drying, pulverizing;
4, encapsulated: that medicated powder is dressed up capsule by Semicapsulefillingmachine.
The capsule that the above-mentioned technological process of process is processed into, when being used for the treatment of the sufferer of ITP, be according to the weight of conditions of patients, the quality of health, the age size is taken the circumstances into consideration medication.Generally speaking, it is a gram that the adult takes this capsule at every turn, uses warm water delivery service; Took in 1st three times, took continuously one to three months.(one month is a course of treatment) gets final product.Child's consumption reduces by half.
Advantage of the present invention is: 1, this medicine is the efficient medicine of ITP, the platelet counts in the ascending peripheral blood clearly, and can reach normal level.
2, with this capsule for treating ITP, dosage is few, has no side effect, and can strengthen patient's self immunologic function, moderate cost, convenient oral simultaneously.3, can avoid using adrenocortical hormones in treating (Western medicine) to bring tangible side reaction etc. with this capsule for treating ITP to the patient.4, the treatment works well, and through the clinical practice of 36 years thousands of cases (part is through the invalid case of western medicine), the above rate of produce effects is more than 80%.This capsule also has the effect that recovers hepatic and renal function.6, usage is simple, meets the requirement of three little (dosage is little, and side effect is little, and toxicity the is little) triple effects (promptly efficient, quick-acting, long-acting) that health ministry advocates in recent years.7, make this capsule and adopt the natural Chinese medicinal herb material, the raw medicinal material wide material sources, process is simple, makes easily, and is with low cost.8, product is taken care of easily.
Embodiment:
Example 1, be equipped with crude drug, added water and send into the multi-function extractor decocting in water, obtained extracting solution in the ratio of 40 kilograms of the Radixs Astragali, 10 kilograms of Rhizoma Cimicifugaes, 15 kilograms of Radix Arnebiae (Radix Lithospermi)s, 25 kilograms in Fructus Jujubae; Extracting solution is sent into the centrifugal thin-film thickener to be concentrated; Send into duster again and dust, drying, pulverizing; Medicated powder is dressed up capsule by Semicapsulefillingmachine.
Example 2, be equipped with crude drug, added water and send into the multi-function extractor decocting in water, obtained extracting solution in the ratio of 40 kilograms of the Radixs Astragali, 10 kilograms of Rhizoma Cimicifugaes, 20 kilograms of Radix Arnebiae (Radix Lithospermi)s, 40 kilograms in Fructus Jujubae, 15 kilograms of Radix Scrophulariaes, 15 kilograms in the Radix Rehmanniae; Extracting solution is sent into the centrifugal thin-film thickener to be concentrated; Send into duster again and dust, drying, pulverizing; Medicated powder is dressed up capsule by Semicapsulefillingmachine.
Example 3, be equipped with crude drug in the ratio of 40 kilograms of the Radixs Astragali, 10 kilograms of Rhizoma Cimicifugaes, 20 kilograms of Radix Arnebiae (Radix Lithospermi)s, 40 kilograms in Fructus Jujubae, 15 kilograms of Radix Scrophulariaes, 15 kilograms in the Radix Rehmanniae, 25 kilograms of Herba Agrimoniaes, 20 kilograms of Folium Callicarpae Formosanae, add water and send into the multi-function extractor decocting in water, obtain extracting solution; Extracting solution is sent into the centrifugal thin-film thickener to be concentrated; Send into duster again and dust, drying, pulverizing; Medicated powder is dressed up capsule by Semicapsulefillingmachine.
Example 4, be equipped with crude drug in 40 kilograms of the Radixs Astragali, 10 kilograms of Rhizoma Cimicifugaes, 20 kilograms of Radix Arnebiae (Radix Lithospermi)s, 40 kilograms in Fructus Jujubae, 615 kilograms of Radix Scrophulariaes, 15 kilograms in the Radix Rehmanniae, 25 kilograms of Herba Agrimoniaes, 20 kilograms of Folium Callicarpae Formosanae, 22 kilograms of Carapax Trionycis, 25 kilograms of ratios of Radix Angelicae Sinensis, add water and send into the multi-function extractor decocting in water, obtain extracting solution; Extracting solution is sent into the centrifugal thin-film thickener to be concentrated; Send into duster again and dust, drying, pulverizing; Medicated powder is dressed up capsule by Semicapsulefillingmachine.
Example 5, press 20 kilograms of the Radixs Astragali, 7 kilograms of Radix Scrophulariaes, 6 kilograms in the Radix Rehmanniae, 10 kilograms of Herba Agrimoniaes, 8 kilograms of Folium Callicarpae Formosanae, 8 kilograms of Carapax Trionycis, 10 kilograms of Radix Angelicae Sinensis, 20 kilograms in Fructus Jujubae, 10 kilograms of the Rhizoma Atractylodis Macrocephalaes, 5 kilograms of Rhizoma Cimicifugaes, the ratio that Radix Arnebiae (Radix Lithospermi) is 7 kilograms has been equipped with crude drug, add water and send into the multi-function extractor decocting in water, obtain extracting solution; Extracting solution is sent into the centrifugal thin-film thickener to be concentrated; Send into duster again and dust, drying, pulverizing; Medicated powder is dressed up capsule by Semicapsulefillingmachine.
The part case history:
Xu so-and-so, the woman, 17, the new people of Tongan District township Wu Tu people from village, the student, seek medical advice to the Xiamen upon somebody's introduction in 2002,7,18, patient's thrombocytopenic purpura before 3 years is imitated time through hospitalization such as Xiamen City hospitals, preceding case is made a definite diagnosis, fail to respond to any medical treatment through the whole bag of tricks, platelet 22,100, the side effect of hormone is apparent.After purpura Yiganning capsule treatment of the present invention (Western medicine such as hormone of stopping using), each 4, every day three times, the platelet of regularly having a blood test was cured fully in November, 2003, and is all normal through inspections such as regular platelet, and platelet still maintains more than 200,000 at present.
Lin, woman, 54, Xiang peace Pu, Liu five shop people from south.Because of suffering from idiopathic thrombocytopenic purpura, aplastic anemia, leukopenia, psoriasis (in JIUYUE, 2000 hysteromyoma operation once) is main treatment 10 years through Xiamen City hospital, the secondary of being in hospital is invalid, platelet is reduced to below 13,000, Syndrome in TCM is seen: white and thin fur, and thready and rapid pulse is string slightly, pale complexion, moon face, typical hormone side effect sign such as buffalo hump, two lower limb have the hemorrhage district of 8 place's lamellars (right 6, left 2), treat (Western medicine such as hormone of stopping using) through purpura Yiganning capsule of the present invention in 2003,8,29.Treatment to 2003, platelet on the 9th, 25 rise to 21,000.Complexion take a favorable turn slightly, adheres to treatment, rises to 75,000 to 2004,12,20 platelet.(normal ten to 300,000).Still in treatment, complexion is good at present, and life does not have institute's discomfort freely, can normally take part in the work.
Chen, woman, 30 years old, Xiangan District Xin Dian people from town, Xiamen, at the beginning of 1975 because of acute idiopathic thrombocytopenic purpura disease rescue in hospital invalid, platelet is reduced to more than 3,000, critically ill, the systemic bleeding patch accounts for body surface area more than 50%, after it is peaceful to take purpura of the present invention, treatment is year surplus, surplus the platelet life to ten ten thousand.Follow up a case by regular visits to that all are normal, married before 4 years, the girl that gives a birth, mother and daughter's situation is all good.
Flood so-and-so, man, 15 years old, Xiangan District Xin Dian people from town, Xiamen, in April, 2003, two treatments was invalid in hospital because of acute thrombocytopenic purpura is sick acute, platelet reduces about 5,000 average every day, reduces to surplus in the of 40,000, sb.'s sickness becomes critical.After it is peaceful to take purpura of the present invention, treat two courses of treatment (two months), platelet recovery is normal.Platelet check in two years is normal value 6 times.After follow up a case by regular visits to that all are normal.
Claims (5)
1, a kind of medicine for the treatment of the idiopathic thrombocytopenic purpura disease, it is characterized in that: the solvent of crude drug is: Radix Astragali 30-60 part, Rhizoma Cimicifugae 8-24 part, Radix Arnebiae (Radix Lithospermi) 10-30 part, four kinds of medical materials of Fructus Jujubae 40-100 part.
2, a kind of medicine for the treatment of the idiopathic thrombocytopenic purpura disease according to claim 1 is characterized in that: also comprise Radix Scrophulariae 6-48 part, Radix Rehmanniae 6-48 part.
3, a kind of medicine for the treatment of the idiopathic thrombocytopenic purpura disease according to claim 2 is characterized in that: also comprise Herba Agrimoniae 20-60 part, Folium Callicarpae Formosanae 16-48 part.
4, a kind of medicine for the treatment of the idiopathic thrombocytopenic purpura disease according to claim 3 is characterized in that: also comprise Carapax Trionycis 16-48 part, Radix Angelicae Sinensis 20-60 part.
5, a kind of medicine for the treatment of the idiopathic thrombocytopenic purpura disease according to claim 1, it is characterized in that: the component of crude drug is: Radix Astragali 30-60 part, Radix Scrophulariae 16-48 part, Radix Rehmanniae 16-48 part, Herba Agrimoniae 20-60 part, Folium Callicarpae Formosanae 16-48 part, Carapax Trionycis 16-48 part, Radix Angelicae Sinensis 20-60 part, Fructus Jujubae 40-100 part, Rhizoma Atractylodis Macrocephalae 20-60 part, Rhizoma Cimicifugae 8-24 part, Radix Arnebiae (Radix Lithospermi) 10-30 part.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658643B (en) * | 2009-09-15 | 2011-04-06 | 刘锋 | Medicament for treating allergic purpura |
| CN101953936B (en) * | 2010-09-19 | 2012-11-07 | 李西爱 | Traditional Chinese medicine preparation for treating immune thrombocytopenia and preparation method thereof |
| CN102648975A (en) * | 2011-11-10 | 2012-08-29 | 薛喜凤 | Traditional Chinese medicine for treating primary thrombocytopenic purpura |
| CN103181967B (en) * | 2011-12-28 | 2016-03-23 | 吉林省松辽制药有限公司 | A kind of oral medicine replenishing qi and nourishing blood tablet for the treatment of qi-blood deficiency syndrome and preparation method thereof |
| CN102920836B (en) * | 2012-11-28 | 2014-05-07 | 徐昌万 | Traditional Chinese medicine composite for treating immune thrombocytopenic purpura |
| CN110638946A (en) * | 2019-09-27 | 2020-01-03 | 李明杰 | Chinese herbal medicine composition for preventing and treating thrombocytopenic purpura |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1217195A (en) * | 1997-11-12 | 1999-05-26 | 内蒙古医学院 | Zhixuening-medicine for stopping bleeding |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1217195A (en) * | 1997-11-12 | 1999-05-26 | 内蒙古医学院 | Zhixuening-medicine for stopping bleeding |
Non-Patent Citations (2)
| Title |
|---|
| 中药升板汤治疗原发性血小板减少性紫癜30例. 王天恩，李惠荣，郑金福，许勇刚.辽宁中医杂志，第23卷第10期. 1996 |
| 中药升板汤治疗原发性血小板减少性紫癜30例. 王天恩，李惠荣，郑金福，许勇刚.辽宁中医杂志，第23卷第10期. 1996 * |
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