CN104645005A - Traditional Chinese medicine composition for treating menopausal somnipathy and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating menopausal somnipathy and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating menopausal somnipathy and a preparation method thereof. The traditional Chinese medicine composition provided by the invention can perfect the sleep quality, has the functions of fatigue resistance and ageing resistance, and has a remarkable effect of perfecting blood stasis. The traditional Chinese medicine composition is mainly prepared from the following raw materials: 8-20 parts of angelica, 5-15 parts of esliptae herba, 5-15 parts of salviae miltiorrhizae, 3-10 parts of hawthorns, 10-25 parts of folium ginkgo, 5-15 parts of cynanchum paniculatum, 10-20 parts of astragalus membranaceus, 3-10 parts of lily, 10-20 parts of polygonum multiflorum, 5-15 parts of honeysuckle, 8-20 parts of polygala tenuifolia, 5-12 parts of pearl grass, 10-20 parts of common cephalanoplos herb, 3-10 parts of banana shrub, 5-15 parts of cortex phellodendri, 3-10 parts of raspberry, 3-10 parts of fructus forsythia, 5-12 parts of honewort, 10-15 parts of herba epimedii, 10-20 parts of puerarin, 3-10 parts of bighead atractylodes rhizome, 5-15 parts of cistanche, 5-15 parts of fructus schizandrae, 5-25 parts of glossy privet fruit and 10-20 parts of licorice. Pharmacological experiments and clinical experiments prove that the traditional Chinese medicine composition has a significant curative effect on menopausal somnipathy, and thus has a broad medical promotion value.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to and be a kind ofly used for the treatment of Chinese medicine composition of climacteric sleep disorder and preparation method thereof.
Background technology
Sleep disorder refers to a class disease that often can not obtain ortho sleep, and the lighter falls asleep disintoxicated, or dreaminess early awakening, and severe one is lain awake all night.Chinese medicine is thought, feelings will is hindered, work and rest mistake degree, weakness due to chronic disease, overaction of the five emotions and eating and drinking without temperance all can cause negative and positive to lose friendship, occurs sleep disorder, and primary disease is divided into the 4 kinds of syndrome determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of deficiency of both the heart and spleen, qi depression to blood stasis, hyperactivity of fire caused by deficiency of YIN and stagnation of phlegm-damp in middle-JIAO.Women’s climacteric sleep disorder is a kind of common disease, can cause certain injury to the body and mind of women.Clinically, caused by physiologic factor, disease factor, medicine factor and dietary factor person case load far less than by psychological factor the case load that causes a disease.Climacteric sleep disorder be climacteric ovarian estrogen secretion to reduce gradually and pituitary gonadotropic hormone increases, cause the momentary imbalance of neuroendocrine, the imbalance of hypothalamic-pituitary-ovarian axle feedback system and function disorder of autonomic nervous system, produce depressed, anxiety neurosis, these produce the main cause of sleep disorder often.
Climacteric, sleep disorder often had following performance: 1, sleep untrue: the sense of reality of sleep insuffience, although many climacteric sleep disorder disease patients can fall into a profound sleep, believe firmly after waking up and oneself do not fall asleep, sleep quality is not high yet.2, poor sleeping quality: although many climacteric sleep disorder disease patients can fall asleep, can feel that sleep can not be recovered from fatigue, still has feeling of fatigue, sleep quality extreme difference after waking up.3, evening, difficulty was fallen asleep: climacteric, sleep disorder disease patient often tossed about in bed, originally very tired, very sleepy feel, and can lie on a bed is exactly can't fall asleep, and the length of one's sleep obviously reduces.4, daytime is tired especially: the climacteric sleep disorder disease patient had feels sleepy daytime, and drowsy, listless, night is excited sleeplessness, learns, has a meeting, attends class and doze off.5, shallow dream of sleeping is many: the normal self-induction of climacteric sleep disorder disease patient is slept unreal, non-sleeping of all seemingly sleeping a night, once daydream of closing one's eyes, once there being sound to wake up, has plenty of early awakening.
At present clinically for climacteric sleep disorder the medicine for the treatment of more, as anxiety, antidepressant drug can improve the anxiety and depression of patient, also can make loosening all muscles, eliminate some Somatic discomfort senses.Other treatment comprises physical training, and tourism is recuperated, and also contributes to short-term and improves tense situation, alleviates stress.But western medical treatment medicine has serious toxic and side effects more, then relapse rate is high in the treatment of short-term life style, can not fundamentally cure climacteric sleep disorder.Chinese medicine is the medical science applied characteristic of China, have accumulated abundant clinical experience by the method for determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs in treatment climacteric sleep disorder.At present a lot of patient can adopt the dialectical compatibility treatment of Chinese medicine, comprehensively regulating function, Yin Yang balancing emotion regulation, can rehabilitation gradually.The Chinese medicine used clinically is at present cut for the uncertain therapeutic efficacy of climacteric sleep disorder, particularly long-term prescription poor effect, and it is definite that the present invention aims to provide a kind of therapeutic effect, the climacteric treatment of sleep disorders medicine that treatment cost is low.
In prior art, chemicals is cured the symptoms, not the disease, and poisonous side effect of medicine is large, and it is fixed that Chinese medicine then exists uncertain therapeutic efficacy, lacks relative medicine preparation.In order to overcome above-mentioned the deficiencies in the prior art, the object of this invention is to provide a kind of Chinese medicine composition effectively can treating climacteric sleep disorder, its instant effect, short treating period, cure rate are high, are applicable to being developed to clinical treatment medicine.
For realizing object of the present invention, existing according to following technical scheme, Chinese medicine of the present invention is made up of the raw material of following weight:
Radix Angelicae Sinensis 8-20 part, Herba Ecliptae 5-15 part, Radix Salviae Miltiorrhizae 5-15 part, Fructus Crataegi 3-10 part, Folium Ginkgo 10-25 part, Radix Cynanchi Paniculati 5-15 part, Radix Astragali 10-20 part, Bulbus Lilii 3-10 part, Radix Polygoni Multiflori 10-20 part, Flos Lonicerae 5-15 part, Radix Polygalae 8-20 part, Herba Phyllanthi Urinariae 5-12 part, Herba Cirsii 10-20 part, 3-10 part with a smile, Cortex Phellodendri 5-15 part, Fructus Rubi 3-10 part, Fructus Forsythiae 3-10 part, Radix Bupleuri 5-12 part, Herba Epimedii 10-15 part, Radix Puerariae 10-20 part, Rhizoma Atractylodis Macrocephalae 3-10 part, Herba Cistanches 5-15 part, Fructus Schisandrae Chinensis 5-15 part, Fructus Ligustri Lucidi 5-25 part, Radix Glycyrrhizae 10-20 part,
According to the difference of Chinese medicine composition to climacteric treatment of sleep disorders effect, above-mentioned Chinese medicine composition basis is preferably as follows:
(1) Radix Angelicae Sinensis 15 parts, Herba Ecliptae 10 parts, Radix Salviae Miltiorrhizae 10 parts, Fructus Crataegi 7 parts, Folium Ginkgo 18 parts, Radix Cynanchi Paniculati 10 parts, the Radix Astragali 15 parts, Bulbus Lilii 7 parts, Radix Polygoni Multiflori 15 parts, Flos Lonicerae 10 parts, Radix Polygalae 14 parts, Herba Phyllanthi Urinariae 9 parts, Herba Cirsii 15 parts, with a smile 7 parts, Cortex Phellodendri 10 parts, Fructus Rubi 7 parts, Fructus Forsythiae 6 parts, Radix Bupleuri 8 parts, Herba Epimedii 13 parts, Radix Puerariae 15 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Herba Cistanches 10 parts, Fructus Schisandrae Chinensis 10 parts, Fructus Ligustri Lucidi 20 parts, 15 parts, Radix Glycyrrhizae.
(2) Radix Angelicae Sinensis 8 parts, Herba Ecliptae 5 parts, Radix Salviae Miltiorrhizae 5 parts, Fructus Crataegi 3 parts, Folium Ginkgo 10 parts, Radix Cynanchi Paniculati 5 parts, the Radix Astragali 10 parts, Bulbus Lilii 3 parts, Radix Polygoni Multiflori 10 parts, Flos Lonicerae 5 parts, Radix Polygalae 8 parts, Herba Phyllanthi Urinariae 5 parts, Herba Cirsii 10 parts, with a smile 3 parts, Cortex Phellodendri 5 parts, Fructus Rubi 3 parts, Fructus Forsythiae 3 parts, Radix Bupleuri 5 parts, Herba Epimedii 10 parts, Radix Puerariae 10 parts, the Rhizoma Atractylodis Macrocephalae 3 parts, Herba Cistanches 5 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Ligustri Lucidi 5 parts, 10 parts, Radix Glycyrrhizae.
(3) Radix Angelicae Sinensis 20 parts, Herba Ecliptae 15 parts, Radix Salviae Miltiorrhizae 15 parts, Fructus Crataegi 10 parts, Folium Ginkgo 25 parts, Radix Cynanchi Paniculati 15 parts, the Radix Astragali 20 parts, Bulbus Lilii 10 parts, Radix Polygoni Multiflori 20 parts, Flos Lonicerae 15 parts, Radix Polygalae 20 parts, Herba Phyllanthi Urinariae 12 parts, Herba Cirsii 20 parts, with a smile 10 parts, Cortex Phellodendri 15 parts, Fructus Rubi 10 parts, Fructus Forsythiae 10 parts, Radix Bupleuri 12 parts, Herba Epimedii 15 parts, Radix Puerariae 20 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Herba Cistanches 15 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Ligustri Lucidi 25 parts, 20 parts, Radix Glycyrrhizae.
(4) Radix Angelicae Sinensis 12 parts, Herba Ecliptae 12 parts, Radix Salviae Miltiorrhizae 10 parts, Fructus Crataegi 5 parts, Folium Ginkgo 16 parts, Radix Cynanchi Paniculati 18 parts, the Radix Astragali 13 parts, Bulbus Lilii 6 parts, Radix Polygoni Multiflori 20 parts, Flos Lonicerae 10 parts, Radix Polygalae 10 parts, Herba Phyllanthi Urinariae 8 parts, Herba Cirsii 16 parts, with a smile 6 parts, Cortex Phellodendri 10 parts, Fructus Rubi 5 parts, Fructus Forsythiae 8 parts, Radix Bupleuri 7 parts, Herba Epimedii 8 parts, Radix Puerariae 14 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Herba Cistanches 5 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Ligustri Lucidi 15 parts, 17 parts, Radix Glycyrrhizae.
In order to express Chinese medicine composition of the present invention better, Chinese medicine composition of the present invention can be prepared into dosage form conventional clinically.Such as, the preparations such as powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule, described pharmaceutical preparation all can prepare according to Chinese medicine preparation preparation method well-known to those skilled in the art.Preferably, Chinese medicine composition of the present invention conveniently preparation technology be prepared into powder, water preparation, tablet or capsule.
Present invention also offers a kind of preparation method of Chinese medicine composition described above, it mainly comprises following step: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, the alcoholic solution that volumetric concentration is 40% ~ 95% is added according to 4 ~ 9 times of coarse powder gross weight, reflux, extract, three times, return time is 2 ~ 5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art can technically prepare conventional Chinese medicine pharmaceutical dosage form clinically, as tablet, capsule etc. in this preparation method.
The present invention also asks to protect the purposes of above-mentioned Chinese medicine composition in preparation treatment climacteric sleep disorder remedies.Wherein said climacteric sleep disorder has a kind of symptom in sleep disorder, blood stasis, fatiguability asthenia, easily aging or symptom combination.Pharmaceutical composition of the present invention, when treating climacteric sleep disorder, demonstrates the activity of remarkable resisting fatigue, antioxidant radical, activating blood circulation to dissipate blood stasis and improving water flood quality.Test examples 7 of the present invention shows, give the effect that positive drug and Chinese medicine composition of the present invention all can obtain significant antifatigue effect and improving water flood quality, wherein the antifatigue effect of Chinese medicine composition high dose group of the present invention and the effect of improving water flood quality and positive controls have pole significant difference, in Chinese medicine composition, dosage group and positive controls have significant difference, this shows that the effect of the high dose group of Chinese medicine composition of the present invention and the antifatigue effect of low dose group and improving water flood quality significantly will be better than positive controls, Chinese medicine composition of the present invention has the therapeutic effect more excellent than existing medicine in the fatigue reaction reducing climacteric sleep disorder patient and improving water flood quality.
In a word, Chinese medicine composition of the present invention, in treatment climacteric sleep disorder, compared with prior art has following advantage:
1) compared with the chemotherapeutic agent of Current therapeutic, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, significantly improve the compliance of climacteric sleep disorder patient, and improve the quality of life of patient.
2) multi-medicament component is contained in Chinese medicine composition of the present invention, action target spot is numerous, pharmacological evaluation shows it and has significant resisting fatigue and improving water flood isoreactivity, efficiently solve the morbidity root of climacteric sleep disorder, it serves the effect for the treatment of both the principal and secondary aspects of a disease to the therapeutic effect of climacteric sleep disorder.
3) the present invention is that inventor is on the basis of secret prescription handed down in the family from generation to generation, in conjunction with the summary of clinical experience for many years, obtain through repeatedly testing, therefore this medicine has unique curative effect to the climacteric sleep disorder that a variety of causes causes, this medicine compatibility science, curative effect is rapid, the advantage that instant effect, short treating period, cure rate are high, expense is little.
Summary of the invention
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but those skilled in the art should know, described embodiment does not also limit the present invention in any way.
(1) example of formulations part
Embodiment 1 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows:
Radix Angelicae Sinensis 8kg, Herba Ecliptae 5kg, Radix Salviae Miltiorrhizae 5kg, Fructus Crataegi 3kg, Folium Ginkgo 10kg, Radix Cynanchi Paniculati 5kg, Radix Astragali 10kg, Bulbus Lilii 3kg, Radix Polygoni Multiflori 10kg, Flos Lonicerae 5kg, Radix Polygalae 8kg, Herba Phyllanthi Urinariae 5kg, Herba Cirsii 10kg, with a smile 3kg, Cortex Phellodendri 5kg, Fructus Rubi 3kg, Fructus Forsythiae 3kg, Radix Bupleuri 5kg, Herba Epimedii 10kg, Radix Puerariae 10kg, Rhizoma Atractylodis Macrocephalae 3kg, Herba Cistanches 5kg, Fructus Schisandrae Chinensis 5kg, Fructus Ligustri Lucidi 5kg, Radix Glycyrrhizae 10kg;
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, add according to 4 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 40%, reflux, extract, three times, return time is 5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Chinese medical concrete is pulverized and adds preparation and commonly use adjuvant and be prepared into tablet or capsule.
Embodiment 2 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows:
Radix Angelicae Sinensis 20kg, Herba Ecliptae 15kg, Radix Salviae Miltiorrhizae 15kg, Fructus Crataegi 10kg, Folium Ginkgo 25kg, Radix Cynanchi Paniculati 15kg, Radix Astragali 20kg, Bulbus Lilii 10kg, Radix Polygoni Multiflori 20kg, Flos Lonicerae 15kg, Radix Polygalae 20kg, Herba Phyllanthi Urinariae 12kg, Herba Cirsii 20kg, with a smile 10kg, Cortex Phellodendri 15kg, Fructus Rubi 10kg, Fructus Forsythiae 10kg, Radix Bupleuri 12kg, Herba Epimedii 15kg, Radix Puerariae 20kg, Rhizoma Atractylodis Macrocephalae 10kg, Herba Cistanches 15kg, Fructus Schisandrae Chinensis 15kg, Fructus Ligustri Lucidi 25kg, Radix Glycyrrhizae 20kg;
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, add according to 5 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 90%, reflux, extract, three times, return time is 3h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Chinese medical concrete is pulverized and adds preparation and commonly use adjuvant and be prepared into tablet or capsule.
Embodiment 3 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows:
Radix Angelicae Sinensis 15kg, Herba Ecliptae 10kg, Radix Salviae Miltiorrhizae 10kg, Fructus Crataegi 7kg, Folium Ginkgo 18kg, Radix Cynanchi Paniculati 10kg, Radix Astragali 15kg, Bulbus Lilii 7kg, Radix Polygoni Multiflori 15kg, Flos Lonicerae 10kg, Radix Polygalae 14kg, Herba Phyllanthi Urinariae 9kg, Herba Cirsii 15kg, with a smile 7kg, Cortex Phellodendri 10kg, Fructus Rubi 7kg, Fructus Forsythiae 6kg, Radix Bupleuri 8kg, Herba Epimedii 13kg, Radix Puerariae 15kg, Rhizoma Atractylodis Macrocephalae 7kg, Herba Cistanches 10kg, Fructus Schisandrae Chinensis 10kg, Fructus Ligustri Lucidi 20kg, Radix Glycyrrhizae 15kg;
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, add according to 5 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 70%, reflux, extract, three times, return time is 4h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Chinese medical concrete is pulverized and adds preparation and commonly use adjuvant and be prepared into tablet or capsule.
Embodiment 4 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows:
Radix Angelicae Sinensis 8kg, Herba Ecliptae 15kg, Radix Salviae Miltiorrhizae 15kg, Fructus Crataegi 3kg, Folium Ginkgo 25kg, Radix Cynanchi Paniculati 15kg, Radix Astragali 10kg, Bulbus Lilii 10kg, Radix Polygoni Multiflori 10kg, Flos Lonicerae 10kg, Radix Polygalae 16kg, Herba Phyllanthi Urinariae 12kg, Herba Cirsii 10kg, with a smile 3kg, Cortex Phellodendri 5kg, Fructus Rubi 10kg, Fructus Forsythiae 10kg, Radix Bupleuri 7kg, Herba Epimedii 10kg, Radix Puerariae 15kg, Rhizoma Atractylodis Macrocephalae 3kg, Herba Cistanches 10kg, Fructus Schisandrae Chinensis 10kg, Fructus Ligustri Lucidi 10kg, Radix Glycyrrhizae 10kg;
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, add according to 5 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 70%, reflux, extract, three times, return time is 4h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Adding ethanol to alcohol content is 75% (v/v), leaves standstill 24 hours, gets supernatant, and reclaim ethanol and concentrate, add water to 1000ml, stir evenly, subpackage, flowing steam sterilization 35min, obtains mixture.
Embodiment 5 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows:
Radix Angelicae Sinensis 12kg, Herba Ecliptae 12kg, Radix Salviae Miltiorrhizae 10kg, Fructus Crataegi 5kg, Folium Ginkgo 16kg, Radix Cynanchi Paniculati 18kg, Radix Astragali 13kg, Bulbus Lilii 6kg, Radix Polygoni Multiflori 20kg, Flos Lonicerae 10kg, Radix Polygalae 10kg, Herba Phyllanthi Urinariae 8kg, Herba Cirsii 16kg, with a smile 6kg, Cortex Phellodendri 10kg, Fructus Rubi 5kg, Fructus Forsythiae 8kg, Radix Bupleuri 7kg, Herba Epimedii 8kg, Radix Puerariae 14kg, Rhizoma Atractylodis Macrocephalae 10kg, Herba Cistanches 5kg, Fructus Schisandrae Chinensis 15kg, Fructus Ligustri Lucidi 15kg, Radix Glycyrrhizae 17kg;
Preparation method is with embodiment 4.
Embodiment 6 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows:
Radix Angelicae Sinensis 14kg, Herba Ecliptae 10kg, Radix Salviae Miltiorrhizae 13kg, Fructus Crataegi 6kg, Folium Ginkgo 20kg, Radix Cynanchi Paniculati 15kg, Radix Astragali 20kg, Bulbus Lilii 3kg, Radix Polygoni Multiflori 16kg, Flos Lonicerae 9kg, Radix Polygalae 11kg, Herba Phyllanthi Urinariae 7kg, Herba Cirsii 16kg, with a smile 7kg, Cortex Phellodendri 11kg, Fructus Rubi 5kg, Fructus Forsythiae 10kg, Radix Bupleuri 12kg, Herba Epimedii 15kg, Radix Puerariae 16kg, Rhizoma Atractylodis Macrocephalae 10kg, Herba Cistanches 15kg, Fructus Schisandrae Chinensis 12kg, Fructus Ligustri Lucidi 18kg, Radix Glycyrrhizae 17kg;
Preparation technology is with embodiment 4.
(2) test examples part
Embodiment 7 Chinese medicine composition anti-fatigue test of the present invention and sleep improvement effect
Resisting fatigue is tested: get healthy Kunming mouse, body weight 18 ~ 22g mice 50, is divided into 5 groups at random.Often organize 10, each 5 of male and female, grouping situation is in table 2.Each treated animal ig administration, positive drug group ig FUKANGNING tablet, Chinese medicine composition is respectively to exceeding the tablet prepared according to the embodiment of the present invention 1, and each group dosage is as shown in table 1, the front physiological saline solution of administration, Normal group ig normal saline.Each group of successive administration 10 days, 1h after last administration, mice being put into water temperature is that the tank of 20 DEG C is swum.Until mice sinks under water, calculate swimming time.
Sleep improvement is tested: separately get healthy Kunming mouse, body weight 20 ~ 22g mice 50, is divided into 5 groups at random, often organizes 10, male female each 5.Grouping situation and dosage design with above-mentioned anti-fatigue test, successive administration 5 days.1h after last medicine, with the dosage mice ig pentobarbital sodium of 35mg/kg, take righting reflex loss as index, record mouse sleep time.
Resisting fatigue experimental result and the sleep improvement experimental result of mice are as shown in table 1.
The resisting fatigue experimental result of table 1 Chinese medicine composition of the present invention and sleep improvement experimental result
| Group | Dosage (by crude drug gauge) | n | Swimming time | The length of one's sleep |
| Normal group | Equal-volume normal saline | 10 | 6.53±1.31 | 25.61±5.34 |
| Positive controls | 7.5mg/kg | 10 | 9.29±1.71 * | 29.35±7.57 * |
| Low group of Chinese medicine composition | 7.5mg/kg | 10 | 9.47±1.52 * | 28.69±8.54 * |
| Group in Chinese medicine composition | 10mg/kg | 10 | 11.26±1.78 **# | 32.69±6.85 **# |
| Chinese medicine composition object height group | 15mg/kg | 10 | 13.25±1.94 **## | 35.97±8.69 **## |
Compare with model control group,
*p < 0.05; Compare with model control group,
*p < 0.01;
Compare with positive controls,
#p < 0.05; Compare with positive controls,
##p < 0.01.
Result display gives positive drug and Chinese medicine composition of the present invention all can obtain significant antifatigue effect, wherein the antifatigue effect of Chinese medicine composition high dose group of the present invention and positive controls have pole significant difference, in Chinese medicine composition, dosage group and positive controls have significant difference, this shows that the high dose group of Chinese medicine composition of the present invention and the antifatigue effect of middle dosage group significantly will be better than positive controls, and the fatigue reaction that Chinese medicine composition of the present invention is reducing climacteric sleep disorder patient has the therapeutic effect more excellent than existing medicine.
Give positive drug and Chinese medicine composition of the present invention all can obtain significant sleep quality improvement result, wherein the sleep quality improvement result of Chinese medicine composition high dose group of the present invention and positive controls have pole significant difference, in Chinese medicine composition, dosage group and positive controls have significant difference, this shows that the high dose group of Chinese medicine composition of the present invention and the antifatigue effect of middle dosage group significantly will be better than positive controls, and Chinese medicine composition of the present invention has the therapeutic effect more excellent than existing medicine in the sleep quality improving climacteric sleep disorder patient.
Claims (8)
1. treat the Chinese medicine composition of climacteric sleep disorder for one kind, it is characterized in that, described Chinese medicine composition obtains primarily of the raw material of following weight portion: Radix Angelicae Sinensis 8-20 part, Herba Ecliptae 5-15 part, Radix Salviae Miltiorrhizae 5-15 part, Fructus Crataegi 3-10 part, Folium Ginkgo 10-25 part, Radix Cynanchi Paniculati 5-15 part, Radix Astragali 10-20 part, Bulbus Lilii 3-10 part, Radix Polygoni Multiflori 10-20 part, Flos Lonicerae 5-15 part, Radix Polygalae 8-20 part, Herba Phyllanthi Urinariae 5-12 part, Herba Cirsii 10-20 part, 3-10 part with a smile, Cortex Phellodendri 5-15 part, Fructus Rubi 3-10 part, Fructus Forsythiae 3-10 part, Radix Bupleuri 5-12 part, Herba Epimedii 10-15 part, Radix Puerariae 10-20 part, Rhizoma Atractylodis Macrocephalae 3-10 part, Herba Cistanches 5-15 part, Fructus Schisandrae Chinensis 5-15 part, Fructus Ligustri Lucidi 5-25 part, Radix Glycyrrhizae 10-20 part.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that, described Chinese medicine composition obtains primarily of the raw material of following weight portion: Radix Angelicae Sinensis 15 parts, Herba Ecliptae 10 parts, Radix Salviae Miltiorrhizae 10 parts, Fructus Crataegi 7 parts, Folium Ginkgo 18 parts, Radix Cynanchi Paniculati 10 parts, the Radix Astragali 15 parts, Bulbus Lilii 7 parts, Radix Polygoni Multiflori 15 parts, Flos Lonicerae 10 parts, Radix Polygalae 14 parts, Herba Phyllanthi Urinariae 9 parts, Herba Cirsii 15 parts, 7 parts with a smile, Cortex Phellodendri 10 parts, Fructus Rubi 7 parts, Fructus Forsythiae 6 parts, Radix Bupleuri 8 parts, Herba Epimedii 13 parts, Radix Puerariae 15 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Herba Cistanches 10 parts, Fructus Schisandrae Chinensis 10 parts, Fructus Ligustri Lucidi 20 parts, 15 parts, Radix Glycyrrhizae.
3. Chinese medicine composition as claimed in claim 1, it is characterized in that, described Chinese medicine composition obtains primarily of the raw material of following weight portion: Radix Angelicae Sinensis 8 parts, Herba Ecliptae 5 parts, Radix Salviae Miltiorrhizae 5 parts, Fructus Crataegi 3 parts, Folium Ginkgo 10 parts, Radix Cynanchi Paniculati 5 parts, the Radix Astragali 10 parts, Bulbus Lilii 3 parts, Radix Polygoni Multiflori 10 parts, Flos Lonicerae 5 parts, Radix Polygalae 8 parts, Herba Phyllanthi Urinariae 5 parts, Herba Cirsii 10 parts, with a smile 3 parts, Cortex Phellodendri 5 parts, Fructus Rubi 3 parts, Fructus Forsythiae 3 parts, Radix Bupleuri 5 parts, Herba Epimedii 10 parts, Radix Puerariae 10 parts, the Rhizoma Atractylodis Macrocephalae 3 parts, Herba Cistanches 5 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Ligustri Lucidi 5 parts, 10 parts, Radix Glycyrrhizae.
4. Chinese medicine composition as claimed in claim 1, it is characterized in that, described Chinese medicine composition obtains primarily of the raw material of following weight portion: Radix Angelicae Sinensis 20 parts, Herba Ecliptae 15 parts, Radix Salviae Miltiorrhizae 15 parts, Fructus Crataegi 10 parts, Folium Ginkgo 25 parts, Radix Cynanchi Paniculati 15 parts, the Radix Astragali 20 parts, Bulbus Lilii 10 parts, Radix Polygoni Multiflori 20 parts, Flos Lonicerae 15 parts, Radix Polygalae 20 parts, Herba Phyllanthi Urinariae 12 parts, Herba Cirsii 20 parts, 10 parts with a smile, Cortex Phellodendri 15 parts, Fructus Rubi 10 parts, Fructus Forsythiae 10 parts, Radix Bupleuri 12 parts, Herba Epimedii 15 parts, Radix Puerariae 20 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Herba Cistanches 15 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Ligustri Lucidi 25 parts, 20 parts, Radix Glycyrrhizae.
5. Chinese medicine composition as claimed in claim 1, it is characterized in that, described Chinese medicine composition obtains primarily of the raw material of following weight portion: Radix Angelicae Sinensis 12 parts, Herba Ecliptae 12 parts, Radix Salviae Miltiorrhizae 10 parts, Fructus Crataegi 5 parts, Folium Ginkgo 16 parts, Radix Cynanchi Paniculati 18 parts, the Radix Astragali 13 parts, Bulbus Lilii 6 parts, Radix Polygoni Multiflori 20 parts, Flos Lonicerae 10 parts, Radix Polygalae 10 parts, Herba Phyllanthi Urinariae 8 parts, Herba Cirsii 16 parts, 6 parts with a smile, Cortex Phellodendri 10 parts, Fructus Rubi 5 parts, Fructus Forsythiae 8 parts, Radix Bupleuri 7 parts, Herba Epimedii 8 parts, Radix Puerariae 14 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Herba Cistanches 5 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Ligustri Lucidi 15 parts, 17 parts, Radix Glycyrrhizae.
6. the Chinese medicine composition as described in as arbitrary in claim 1-5, it is characterized in that, described Chinese medicine composition is powder, water preparation, tablet or capsule.
7. prepare the method for the arbitrary described Chinese medicine composition of claim 1-5 for one kind, it is characterized in that, described preparation method comprises the steps: that getting the above-mentioned Chinese crude drug of recipe quantity is broken into coarse powder, adds according to 4 ~ 9 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 40% ~ 95%, reflux, extract, three times, return time is 2 ~ 5h, filter, filtrate recycling ethanol, cold filtration, wash with water, after drying, namely obtain Chinese medical concrete; Those skilled in the art can technically prepare conventional Chinese medicine pharmaceutical dosage form clinically in this preparation method.
8. the purposes of the arbitrary described Chinese medicine composition of claim 1-5 in preparation climacteric treatment of sleep disorders medicine.
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