CN102920836B - Traditional Chinese medicine composite for treating immune thrombocytopenic purpura - Google Patents
Traditional Chinese medicine composite for treating immune thrombocytopenic purpura Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composite for treating immune thrombocytopenic purpura. The traditional Chinese medicine composite is prepared from the following raw materials in parts by weight: 10-30 parts of cornu bubali, 10-30 parts of indigo naturalis, 10-30 parts of lithospermum, 10-30 parts of pseudo-ginseng, 10-30 parts of selaginella tamariscina, 10-30 parts of angelica sinensis, 1-5 parts of ginseng, 10-30 parts of astragalus mongholicus, 10-30 parts of rehmannia root, 1-5 parts of antler slices, 10-30 parts of tortoise shell, 1-5 parts of placenta hominis, 10-15 parts of radix salviae miltiorrhizae, 10-30 parts of polygonum cuspidatum and 10-20 parts of cortex moutan. The traditional Chinese medicine composite is prepared into powder, pills, pastes or tablets by weighing the raw materials in the weight proportion and using a conventional traditional Chinese preparation method. The traditional Chinese medicine composite is high in components and is quantitatively blended; the dosage form can be powder, pills, pastes or tablets; and the medicines are matched with each other, the composite has the functions of replenishing qi to invigorate the spleen, governing the blood, tonifying kidney to perform spermatogenesis and culture the blood, promoting blood circulation to remove blood stasis to generate new blood, so that the human immunocompetence can be obviously improved, the micro-circulation is improved, the blood cells are increased, and the worries and the poor reaction of the patients caused by hormonotherapy of western medicine and spleen cutting are improved.
Description
Technical field
The present invention relates to Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for the treatment of immunologic thrombocytopenic purpura.
Background technology
Purpura is more common clinically sign, often because platelet counts reduces, causes, therefore general term thrombocytopenic purpura.Wherein common with immunologic thrombocytopenic purpura, though thrombotic thrombocytopenic purpura sickness rate is lower, mortality rate is higher.Idiopathic thrombocytopenic purpura is considered to agnogenic hemorrhage in the past always, and large quantity research has in recent years confirmed that primary disease is relevant with immunoreation, therefore should be called idiopathic thrombocytopenic purpura (being also called for short ITP).The Hematologic Features of primary disease is thrombocytopenia in peripheral blood, and platelet surface is combined with antiplatelet antibody, and platelet life span shortens, and bone marrow megakaryocyte can increase and thrombocytopoiesis obstacle by compensatory.
In prior art, the method for the treatment of immunologic thrombocytopenic purpura is a lot.Wherein, modal method is hormonotherapy and the Splenectomy for treating method of Western medicine, but all has side effect, the trouble and worry that can bring or untoward reaction.Therefore, Study of Traditional Chinese Medicine formula becomes those skilled in the art's important selection.
Summary of the invention
For prior art above shortcomings, the object of the present invention is to provide a kind of Chinese medicine composition for the treatment of immunologic thrombocytopenic purpura, to improve the hormonotherapy of Western medicine and to cut trouble and worry and the untoward reaction that spleen brings to patient, solve the slow defect of other Chinese Herbs.
Realize above-mentioned purpose, the present invention adopts following technical scheme: a kind of Chinese medicine composition for the treatment of immunologic thrombocytopenic purpura, and it is to be made by following portions by weight proportioning raw materials:
Cornu Bubali 10-30 part; Indigo Naturalis 10-30 part; Radix Arnebiae (Radix Lithospermi) 10-30 part; Radix Notoginseng 10-30 part; Roll up white 10-30 part; Radix Angelicae Sinensis 10-30 part; Radix Ginseng 1-5 part; Radix Astragali 10-30 part; Radix Rehmanniae 10-30 part; Cornu Cervi tablet 1-5 part; Carapax Et Plastrum Testudinis 10-30 part; Placenta Hominis 1-5 part; Radix Salviae Miltiorrhizae 10-15 part; Rhizoma Polygoni Cuspidati 10-30 part; Cortex Moutan 10-20 part;
The preparation method of described Chinese medicine composition, takes raw material by above-mentioned weight proportion, with the conventional preparation method of Chinese medicine, makes powder, pill, cream system, tablet.
Compared to existing technology, the present invention has following beneficial effect:
Treatment by Chinese herbs ITP determined curative effect of the present invention, safety, few side effects; And prescription is superior, from thousands of kinds of Chinese medicines screening and go out ten five tastes, be quantitatively mixed, dosage form is powder, pill, unguentum, tablet.In compositions, Radix Ginseng, the Radix Astragali, Radix Angelicae Sinensis invigorating the spleen and replenishing QI, nourish blood, take the photograph blood; Cornu Cervi tablet, Placenta Hominis, the strong marrow of Carapax Et Plastrum Testudinis Zishen fill fine, with activated bone marrow hemopoietic, the stable platelet that promotes; The Radix Rehmanniae, Cortex Moutan, Carapax Et Plastrum Testudinis, Cornu Bubali, Rhizoma Polygoni Cuspidati, Indigo Naturalis replenishing YIN and removing heat removing pathogenic heat from blood and toxic substance from the body, to control the absurd row of its inclined to one side YinXuXueRe, the card that blood oozing from the body openings or subcuta neous tissue arteries and veins is outer; Radix Salviae Miltiorrhizae, Radix Notoginseng, the white promoting blood flow and remove blood stasis and stop bleeding of volume, and do not hinder fresh blood.
All medicines share, and have replenishing QI to invigorate the spleen, system blood, and kidney-tonifying sperm-generating nourishes blood, and blood circulation promoting and blood stasis dispelling tissue regeneration promoting is taken the photograph the merit of blood.Can significantly improve human body immunity, improve microcirculation, promote platelet, improve the hormonotherapy of Western medicine and cut trouble and worry and the untoward reaction that spleen brings to patient.
By to the hundreds of routine clinical observation on the therapeutic effect of immunologic thrombocytopenic purpura, effective percentage reaches 92%, and inefficiency is 8%.The present invention has instant effect, and relapse rate is low, and medical expense is few, the long-term taking advantage such as also have no adverse reaction.Meanwhile, chronic aplastic anemia anemia, leukopenia are also had to good therapeutic effect.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described in further detail.
Concrete formula sees table:
| Formula | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Cornu Bubali | 10 | 10 | 15 | 30 | 20 |
| Indigo Naturalis | 10 | 10 | 10 | 30 | 15 |
| Radix Arnebiae (Radix Lithospermi) | 10 | 10 | 15 | 30 | 20 |
| Radix Notoginseng | 10 | 10 | 10 | 18 | 30 |
| Volume is white | 10 | 10 | 15 | 18 | 30 |
| Radix Angelicae Sinensis | 30 | 30 | 30 | 20 | 30 |
| Radix Ginseng | 5 | 5 | 5 | 1 | 3 |
| The Radix Astragali | 30 | 30 | 30 | 10 | 25 |
| The Radix Rehmanniae | 15 | 20 | 20 | 30 | 20 |
| Cornu Cervi tablet | 5 | 5 | 5 | 1 | 3 |
| Carapax Et Plastrum Testudinis | 10 | 10 | 10 | 30 | 18 |
| Placenta Hominis | 5 | 5 | 5 | 1 | 3 |
| Radix Salviae Miltiorrhizae | 10 | 10 | 10 | 15 | 12 |
| Rhizoma Polygoni Cuspidati | 10 | 10 | 15 | 30 | 15 |
| Cortex Moutan | 10 | 10 | 10 | 20 | 15 |
Two, one of can be the optionally following method of the making of Chinese medicine composition:
1, by above-mentioned part by weight proportioning, make pill.
2, by above-mentioned part by weight proportioning, make unguentum.
Three, proven case:
1, Chen, female, 35 years old.First visit on July 1 in 2008.Patient occurred unclean through row first quarter moon before 1 year, gynaecological examination is normal, light red through color, and amount is many, dizziness, tinnitus, weak, two skin of lower extremity ecchymosis.Mou county people's hospital is diagnosed as idiopathic thrombocytopenic purpura.The platelet 15 * 10 of having a blood test
9/ L, treats after February with XUEKANG KOUFUYE prednisone, and the dermal ecchymosis goes down, and Jing Hang 5 Japanese sides are clean, dizzy, weak alleviating.The platelet 102 * 10 of having a blood test
9/ L rises to normally.The oral decrement gradually of prednisone, while taking to 10mg on the 1st, skin is observed again new ecchymosis, and menstrual phase extends to 12 only.The platelet 25 * 10 of having a blood test
9/ L.Dizzy weak the increasing the weight of of patient, lack of appetite, timid cold, frequently, shallow complexion, sleeps poor nocturia.To Chongqing large hospital diagnosis and treatment, the routine of having a blood test: WBC7.6 * 10
9/ L, Hb132g/L; PLT21 * 10
9/ L, bone marrow aspiration is diagnosed as " idiopathic thrombocytopenic purpura ", and blood coagulation spectrum is normal, and cardiopulmonary are normal, and liver spleen is little.Give hormone, add immunosuppressant treatment.But patient worries, hormone side effect is too large, and last time hormone therapy is unsuccessfully refused medication in addition, after being introduced in here tcm diagnosis and treatment.Card is shown in: patient's shallow complexion, and lassitude, dizzy weak, tinnitus, fear of cold limb are cool, and nocturia is frequent, lack of appetite, xerostomia is tasteless, skin of lower extremity ecchymosis, thin white fur of tongue, pale tongue, thready pulse is number slightly.Tcm diagnosis: blood disorder (flesh [blood is ugly] L ü).Card belongs to spleen kidney two and loses, asthenia of essence and blood, QI failing to control blood.Prescription: ginseng sees the above table embodiment 1; By above-mentioned part by weight, be mixed with pill, take after 20 days, patient cables it: dizzy weak alleviating, skin of lower extremity ecchymosis reduces.Advise its following the service 15 days, examination platelet.Further consultation on August 5 in 2008: patient has rosy cheeks, spirit is rather good, and dizziness is weak obviously to alleviate, and skin of lower extremity stasis of blood class disappears substantially, the platelet 88 * 10 of having a blood test
9/ L, effect is remarkable, and following the service chases after January to be controlled.Within 2008, JIUYUE is examined on the 10th, and all diseases of patient disappear, and strong as ordinary person, the platelet of having a blood test shows: PLT113 * 10
9/ L, recovers normal, and patient requires after treatment 2 months.After 2 years, former patient is with friend to come here to diagnose a disease, and the platelet of announcement, after treatment by Chinese herbs last time, keeps normal always, then without other discomfort.
2, Zhang, female, 5 years old, first visit on July 1 in 2010.Infant is because of thrombocytopenic purpura in May, 1.Recently, aggravation, moves in Chongqing large hospital.The routine of having a blood test is shown: WBC9.52 * 10
9/ L, N:0.10, L:0.84; RBC:3.59 * 10
12/ L, Hb99g/L; PLT30 * 10
9/ L.Bone marrow smear: meet thrombocytopenic purpura (ITP).Diagnosis: chronic thombocytopenic purpura, granulocytopenia? give prednisone 5mg, 2 times on the 1st, in conjunction with symptomatic treatment.The routine of having a blood test after 1 week is shown: WBC10.6 * 10
9/ L, N:0.05, L:0.75; Hb100g/L; PLT102 * 10
9/ L, infant body temperature, breathing, heart rate are normal, liver spleen is little, and two skin of lower extremity are dispersed in old ecchymosis.Leave hospital and continue to take prednisone 5mg/ time, a twice-daily, D-Cal 0.3g/ time, a twice-daily.After two weeks, the infant state of an illness occurs again repeatedly, and new petechia appears in two skin of lower extremity, lassitude, and dizzy weak, the decreased food intake of receiving is few.Move in certain large hospital, the routine of having a blood test is shown: WBC7.10 * 10
9/ L, N:0.47, L:0.41; RBC:4.2 * 10
12/ L, Hb89g/L; PLT21 * 10
9/ L, gives the symptomatic treatments such as platelet transfusion.Parents of hospitalized children is worried very much, noses about everywhere this sick method for the treatment of.By friend, introduce here to require Chinese medicine diagnosis and treatment.Examine and see: infant hair is sparse, shallow complexion, omits edema, pale lips, and lassitude, is off one's feed, and lazy speech happiness is sleeping, and yellow urine, is hard and dry, thin white fur of tongue, pale tongue, deep-thready pulse.Tcm diagnosis: blood disorder (flesh blood is ugly).Ginseng sees the above table embodiment 2, is mixed with unguentum takes by above-mentioned part by weight.Take after 30 days, infant carrys out further consultation, and the routine of having a blood test is shown: WBC6.5 * 10
9/ L, RBC:4.3 * 10
12/ L, Hb125g/L; PLT68 * 10
9/ L (platelet).Spirit is better, has rosy cheeks, and head has grown soft of much black, and lower limb ecchymosis starts to disappear, food can, two is just normal.Parents with Children is automatic stop hormone, still requires treatment by Chinese herbs, following the service 2 months.15 days three October in 2010 examines, and the platelet of having a blood test shows: PLT125 * 10
9/ L, recovers normal, and infant is again without other discomfort, and new ecchymosis, does not appear in two skin of lower extremity yet.It can consider drug withdrawal, but Parents with Children is feared its recurrence, still requires to cure 3 months.After 1 year, infant goes home to celebrate a festival with its father and mother, and spy comes here to visit, and this disease of announcement heals, and daughter prepares to go to school.
3, Liu: female, 36 years old, first visit on May 24 in 2004.Patient goes out to celebrate a festival on March 8th, 2002, suddenly dizziness, cardiopalmus, fall in ground, unconscious, after its family members, repeatedly exhale sum to pinch to press in people, wake up as usual afterwards, do not draw attention and treat.Patient was recurred and was fainted again on August 2nd, 2004, and weak after waking up, lack of appetite, breathes hard, and cardiopalmus is moved in certain county people's hospital, is diagnosed as thrombocytopenia.Its routine blood test shows: WBC4.5 * 10
9/ L, RBC:3.25 * 10
12/ L, Hb90g/L; PLT21 * 10
9/ L
Liver spleen is little, doubts blood spectrum normal, and cardiopulmonary are normal, give XUEKANG KOUFUYE, compound recipe soap tablet, and the symptomatic treatments such as platelet transfusion are after January, the platelet of having a blood test: PLT85 * 10
9/ L, Hb125g/L; WBC4.7 * 10
9/ L, symptom takes a turn for the better and leaves hospital.Due to economic conditions, the not continuous medicine of using of patient.On October 2nd, 2004, patient faints suddenly in being on duty on the way, unconscious, through colleague, is sent to after hospital emergency, proceeds to Chengdu front three hospital treatment.While being admitted to hospital, the routine of having a blood test is shown: WBC4.7 * 10
9/ L, RBC:3.6 * 10
12/ L, Hb85g/L; PLT18 * 10
9/ L, liver spleen is little, and blood coagulation spectrum is normal.Bone marrow aspiration diagnosis: idiopathic thrombocytopenic purpura.Give platelet transfusion, human γ-globulin, the symptomatic treatments such as oral meticorten, after 20 days, platelet is always in 15-22 * 10
9/ L fluctuation, patient is weak, cardiopalmus, lack of appetite, skin of lower extremity ecchymosis.Attending physician requires patient to perform to cut spleen operation mental preparation, but patient and family members thereof disagree with and cut spleen and initiatively leave hospital.On December 5th, 2004, carry out upon somebody's introduction here requirement Chinese medicine.Card is shown in: patient's lassitude, shallow complexion, lip is light without pool, lack of appetite, xerostomia, drink cold, large constipation, menstruation first quarter moon is unclean, two skin of lower extremity ecchymosis present, thin white fur of tongue, thready pulse is number slightly.Tcm diagnosis: blood disorder, card belongs to deficiency of both QI and YIN, asthenia of essence and blood, bleeding due to blood-heat.Ginseng sees the above table embodiment 3, by above-mentioned mass ratio, is mixed with pill, takes 30 days.Further consultation on January 10 in 2005, the platelet 75 * 10 of having a blood test
9/ L, all proofs are aobvious to be alleviated, and advises its following the service 2 months, notes not flu, prohibits raw food, distantly related thing.25 days three March in 2005 examines, the platelet 210 * 10 of having a blood test
9/ L, strong as ordinary person, consideration drug withdrawal, but patient still requires to chase after and controls 3 months to consolidate it.In May, 2007, former patient lends the poor here of just coming, the repeatedly check over the past two years of announcements, and platelet keeps normally always, and this disease does not recur again.
5 pairs of thrombocytopenia of embodiment 4 and embodiment all have obvious curative effects.
Finally it should be noted that, above embodiment is only in order to illustrate technical scheme of the present invention but not restriction technologies scheme, although applicant has been described in detail the present invention with reference to preferred embodiment, those of ordinary skill in the art is to be understood that, those are modified or are equal to replacement technical scheme of the present invention, and do not depart from aim and the scope of the technical program, all should be encompassed in the middle of claim scope of the present invention.
Claims (1)
1. a Chinese medicine composition for the treatment of immunologic thrombocytopenic purpura, is characterized in that, with Chinese medicine conventional method, makes powder, pill, unguentum or tablet; It is to be made by the crude drug of following quality proportioning:
Cornu Bubali 10-30 part; Indigo Naturalis 10-30 part; Radix Arnebiae (Radix Lithospermi) 10-30 part;
Radix Notoginseng 10-30 part; Herba Selaginellae 10-30 part; Radix Angelicae Sinensis 10-30 part;
Radix Ginseng 1-5 part; Radix Astragali 10-30 part, Radix Rehmanniae 10-30 part;
Cornu Cervi tablet 1-5 part; Carapax Et Plastrum Testudinis 10-30 part; Placenta Hominis 1-5 part;
Radix Salviae Miltiorrhizae 10-15 part; Rhizoma Polygoni Cuspidati 10-30 part; Cortex Moutan 15-20 part.
2. a treatment immunologic thrombocytopenic purpura Chinese medicine composition, is characterized in that, with Chinese medicine conventional method, makes powder, pill, unguentum or tablet; It is to be made by the crude drug of following quality proportioning: 5 parts of Radix Ginsengs, 30 parts of the Radixs Astragali, 15 parts, the Radix Rehmanniae, 5 parts of Cornu Cervi tablets, 10 parts of Carapax Et Plastrum Testudiniss, 5 parts of Placenta Hominiss, 10 parts of Indigo Naturaliss, 10 parts of Cornu Bubalis, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Rhizoma Polygoni Cuspidati, 10 parts of Cortex Moutans, 30 parts of Radix Angelicae Sinensis, 10 parts of Herba Selaginellaes, 10 parts of Radix Notoginseng, 10 parts of Radix Arnebiae (Radix Lithospermi)s.
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| CN103720916B (en) * | 2014-01-17 | 2016-04-13 | 青岛市中心医院 | Tea ointment of the thrombocytopenic purpura that alleviation causes because of radiation and preparation method thereof |
| CN105963392A (en) * | 2016-07-04 | 2016-09-28 | 上海世道健康科技有限公司 | Traditional Chinese medicine composition, preparation and preparation method and purpose thereof |
| CN108186809B (en) * | 2018-02-06 | 2023-01-10 | 丁樱 | Heat-clearing and bleeding-stopping granules and preparation method thereof |
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