CN104606636A - Traditional Chinese medicine composition for treating depression and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating depression and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating depression and a preparation method thereof. The traditional Chinese medicine composition consists of the following traditional Chinese medicines: rhizoma acori graminei, radix curcumae, American ginseng and Hypericum perforatum. The traditional Chinese medicine composition provided by the invention achieves warm and cold combination, simultaneous consideration of deficiency and excess and combined use of qi and blood, is precise and appropriate in compatibility of medicines, has the effects of activating spleen and clearing damp, soothing liver-qi stagnation, tonifying qi and strengthening the spleen and eliminating phlegm by cooling and is well applied to clinical application on patients suffering from depression with the symptoms such as stagnation of liver qi and spleen deficiency and dampness stagnation. The clinical test and animal experiment prove that the traditional Chinese medicine composition provided by the invention has the characteristics that special effects are achieved through a small prescription, both symptoms and root causes are treated and the application is convenient; and the clinical application effect is obvious and is superior to that of the existing technology.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to Chinese medicine composition of a kind of Cure of depression and preparation method thereof.
Background technology
Along with increasingly sharpening of social competition, the quickening day by day of rhythm of life, the weary art of releiving of multiple pressure, increasing people is subjected to the torment of depression, age of onset declines year by year, patient group expands year by year, drastically influence physical and mental health and the life happiness of people, also brings white elephant to entire society.Predict according to World Health Organization (WHO) (WHO), whole world depression rate is 3.1%, and Present Global has patients with depression about 3.4 hundred million, has become the large illness in the world the 4th, and to the year two thousand twenty, depression is only second to the second largest disease of cardiovascular disease by becoming.
Depression has the advantages that sickness rate is high, hazardness is large, relapse rate is high.Patient to be gone down and except the emotional symptoms such as enjoyment forfeiture except emotion continues low, pessimistic, interest, how with retardation of thinking, hypomnesis, aprosexia, sleep disorder, Somatic discomfort sense, poor appetite, shortage initiative, worry oneself to suffer from various disease and self-accusation from symptoms such as crime, can suicide be there is in severe patient.Depression seriously annoyings that people work normally, studying and living, and its high homicide rate tendency also directly affects social stability, therefore, society should be caused to pay attention to.
The patients with depression of current China is based on light, moderate, and the psychiatric scholar of domestic majority thinks, the simple puzzlement relying on psychotherapy can not solve light moderate depressive patients.And clinical antidepressant medicine mainly comprises tricyclic antidepressants, selectivity serotonin (5-HT) re uptake presses down the chemicals such as agent, oxidase inhibitor, the application of these medicines needs systematic treating that is enough, pedicure journey, although there is certain therapeutical effect to the depression of various degree, but also there is the drawback that untoward reaction is larger, and there is to antidepressant Western medicine psychology of significantly conflicting in the patients with depression of China's majority, cause Treatment Compliance difference, the situation that treatment expulsion rate is high.Therefore from Chinese herbal medicine, find the important directions that effective, safe antidepressants have become research both at home and abroad in recent years.
Chinese patent medicine conventional at present mainly contains Wu Liang Su Hai wetland, capsule for reliving liver and reliving upset, JIEYUANSHEN KELI, JIAWEI XIAOYAOWAN, depression alleviating pills, precious Siberian cocklebur depression alleviating pills etc., and the peaceful strongly fragrant Special-shaped sheet studied, the peaceful sheet of dissipating depression of QI etc., also has following relevant report:
CN200910059522.8 (CN101590207A) discloses a kind of pharmaceutical composition of Cure of depression, and it is the Chinese medicine preparation be prepared from for primary raw material with Radix Curcumae, Herba Hyperici Monogyni, Fructus Tribuli, Rhizoma Acori Graminei.
CN200510066317.6 (CN1850255A) discloses and a kind ofly treats pharmaceutical composition of depression or anxiety neurosis and preparation method thereof, this pharmaceutical composition with Herba Hyperici perforati, Radix Curcumae, Rhizoma Acori Graminei, Radix Ginseng, Radix Polygalae, Flos Albiziae for raw material.
In above-mentioned report except Rhizoma Acori Graminei, Radix Curcumae, Herba Hyperici Monogyni, one of them adds Fructus Tribuli, pungent, bitter, and tepor is slightly poisonous, returns Liver Channel.There is suppressing the hyperactive liver soothing the liver, promoting blood circulation by removing wind, improving eyesight, antipruritic effect, because of it, there is certain dispersing the stagnated live-QI to relieve the stagnation of QI function therefore for this, still belong to soothing the liver product in the composition.And composition Radix Panacis Quinquefoliis different in this compositions, there is air making-up and spleen enlivening effect, fully can look after the diseases such as depression spleen and stomach function is low, mechanism of qi is not enough, whole body fatigue and weak.
Though and adopt ginseng qi-tonifying spleen invigorating in another compositions, warm-dryness syndrome is partial to by Radix Ginseng, and benefiting action is partially strong, easily helps humidogene heat.And Radix Panacis Quinquefolii is relatively cool, can QI invigorating and not dry than Radix Ginseng.
The Chinese medicine of current Cure of depression is set about from the basic pathogenesis of depression of liver-QI mostly, adopt the method for depressed liver-energy dispersing and QI regulating, tranquilizing by nourishing the heart more, or be aided with nourish heart, calm the nerves, spleen invigorating, or have the product such as purging liver-fire concurrently, the consideration of the rarer pathogenesis from depression of liver-QI, insufficiency of the spleen phlegm-damp.
The scorching academician of traditional Chinese medical science encephalopathy scholar Wang Yong thinks, depression has the feature of stagnation of QI dampness more, wetly goes, and spleen is strongly fragrant also to be separated, three burnt mechanism of qi hinges and unobstructed, therefore whole body pent-up then removes, and point out depression main pathogenesis and depression of liver-QI, stagnation of dampness due to deficiency of the spleen is in close relations.
Therefore, based on scorching academician's " resolving depression of the being amusing " academic thought of Wang Yong, in order to make up the deficiency of existing prescription, inventor is by the experiment of a large amount of list of references, Clinical practice experience and range of animal, and optimization of C/C composites gradually, finally determines the present invention.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition of Cure of depression.
Another object of the present invention is to the preparation method of the Chinese medicine composition that a kind of Cure of depression is provided.
The Chinese medicine composition of a kind of Cure of depression provided by the invention, it is made up of following Chinese medicine: Rhizoma Acori Graminei, Radix Curcumae, Radix Panacis Quinquefolii, Herba Hyperici Monogyni.
Preferably, described Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Acori Graminei 10-30 part, Radix Curcumae 10-30 part, Radix Panacis Quinquefolii 10-30 part, Herba Hyperici Monogyni 10-30 part.
Further preferably, described Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Acori Graminei 20-30 part, Radix Curcumae 20-30 part, Radix Panacis Quinquefolii 20-30 part, Herba Hyperici Monogyni 20-30 part.
Further preferred, described Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Acori Graminei 30 parts, Radix Curcumae 30 parts, Radix Panacis Quinquefolii 20-30 part, Herba Hyperici Monogyni 20-30 part.
The most preferably, described Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Acori Graminei 30 parts, Radix Curcumae 30 parts, Radix Panacis Quinquefolii 30 parts, Herba Hyperici Monogyni 30 parts.
In above-mentioned Chinese medicine composition:
Described weight portion can be the known unit of weights of field of medicaments such as μ g, mg, g, kg, also can be its multiple, as 1/10,1/100,10 times, 100 times etc.
Present invention also offers the method preparing above-mentioned Chinese medicine composition, the method comprises the following steps: take each composition according to proportioning, then pulverize, to obtain final product.
Present invention also offers the method that another prepares above-mentioned Chinese medicine composition, the method comprises the following steps: take Rhizoma Acori Graminei, Radix Curcumae, Radix Panacis Quinquefolii and Herba Hyperici Monogyni according to proportioning, with soak by water 2-3 time, each water consumption is the 2-8 times amount of Chinese medicine gross weight, and each decocting time is 0.5-2 hour, and twice decocting liquid, filter, concentrated, dry, to obtain final product.
Present invention also offers the preparation containing above-mentioned Chinese medicine composition, said preparation is made up separately of Chinese medicine composition or is formed by with Chinese medicine composition and pharmaceutically acceptable carrier.
Described preparation is oral formulations, the oral formulations such as described oral formulations is water extract, tablet, pill (described pill is water-honeyed pill or concentrated pill) powder, capsule, oral liquid, granule or health tea; Described external preparation is paster or medicated pillow.
The present invention is mainly and orally uses, and the mode of taking is daytime every day take 2 times, and two minor tick 6 hours are advisable.
Present invention also offers above-mentioned Chinese medicine composition or the application of its preparation in the medicine preparing Cure of depression.
The Chinese medicine composition of Cure of depression provided by the invention has the following advantages:
1, Chinese medicine composition provided by the invention is made up of Rhizoma Acori Graminei, Radix Curcumae, Radix Panacis Quinquefolii, Herba Hyperici Monogyni, wherein:
Rhizoma Acori Graminei is the dry rhizome of acorus gramineus araceae plant, and property is pungent, warm, bitter in the mouth, GUIXIN, stomach warp, has effect of refreshment of having one's ideas straightened out, removing dampness to restore normal function of the stomach, beneficial will of allaying excitement.Rhizoma Acori Graminei is pungent to be opened bitter dry temperature and leads to, and fragrance is walked to alter, and not only enters heart channel, and happy key, beneficial intelligence, tranquilizing mind, can enter stomach warp again, and kind removing dampness is turbid, stomach of being amusing, circulation of qi promoting are stagnant." Bencao Congxin ": " arduous and warm, fragrance and faling apart, happy hole, sharp nine orifices, improve visual and auditory acuity, sounding sound, dries except wind, and by expectorant removing food stagnancy, whet the appetite alleviating distention in middle-JIAO ... "
Radix Curcumae is the dried root of zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary or Rhizoma Curcumae, and acrid in the mouth, hardship, cold in nature, return liver, gallbladder, heart channel, have promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clear away heart-fire removing heat from blood, effect of promoting the function of the gallbladder to alleviate jaundice.The pungent loose hardship of Radix Curcumae is let out, can resolving depression have one's ideas straightened out, and cold in nature enter heart channel, can clear away heart-fire again heat, therefore can be used for turbid forgetful, the coma disease of hoodwinking thinking of expectorant.Essentials of Matea Medica: " circulation of qi promoting, resolving depression let out blood, removing blood stasis with potent drugs.Cool heat in the heart, loose stagnation of liver-QI.”
Radix Panacis Quinquefolii is the root of Araliaceae Radix Panacis Quinquefolii, sweet, micro-hardship, cool.Return lung, the heart, kidney, spleen channel, there is the effect of boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Compared with Radix Ginseng, cooler in the nature, hold concurrently when tonification spleen lung qi the moon and to relieve inflammation or internal heat yin nourishing, can also reinforcing the heart gas, strengthening the spleen gas, the moon that can nourish heart of holding concurrently, grows spleen cloudy." Records of Tradition Chinese and Western Medicine in Combination ": " can subsidize edema caused by disorder of QI, holding concurrently can tonification blood system, for it is cool in nature and mend, all wish Radix Ginsengs and be not subject to the temperature compensation person of the Radix Ginseng, all can this generation it.”
Herba Hyperici Monogyni, has another name called Herba Hyperici perforati, and Europe is commonly called as Herba Hyperici perforati, and belong to Hypericum Guttiferae herbaceos perennial, its property is put down, and acrid in the mouth is pained, has effect of heat-clearing and toxic substances removing, astringing to arrest bleeding, dampness removing.Herba Hyperici perforati extract is mainly used in the disease such as Cure of depression, hepatitis, because it is evident in efficacy, side effect is little, use safety, has become the drug of first choice of depression at present in states such as America and Europes.
The present invention is the Chinese medicine composition forming a kind of Cure of depression with resolving depression effect of being amusing based on depression " stagnation of liver-QI spleen wets " pathogenesis, and wherein Rhizoma Acori Graminei is warm in nature, removing dampness of can being amusing, refreshment of having one's ideas straightened out, and is monarch drug; Radix Curcumae is cool in nature, promoting QI circulation for relieving depression, clears away heart-fire and invigorates blood circulation, with being ministerial drug, both can vital energy regualting and blood circulation-promoting, and Rhizoma Acori Graminei clearing and dissipating phlegm-heat can be coordinated again; Radix Panacis Quinquefolii is cool in nature, air making-up and spleen enlivening, replenishing YIN and removing heat, looks after depression spleen and stomach function disease that is low and fatigue and weak all over the body, and not dry than ginseng qi-tonifying; The strongly fragrant then easily heat-transformation for a long time of phlegm-damp, Herba Hyperici Monogyni herb is cool in nature, has the merit of clearing away heat-damp and promoting diuresis, and its extract itself has antidepressant effect.
The cool combination of full side's temperature, deficiency and excess is taken into account, QI and blood use, and compatibility is precise and appropriate, damp eliminating of being amusing, dispersing the stagnated live-QI to relieve the stagnation of QI, air making-up and spleen enlivening, removing heat-phlegm, is applicable to the clinical practice of depression of liver-QI, spleen asthenia and dampness retention patients with depression better.
2, current, on existing market, the Chinese medicine of Cure of depression is mostly based on soothing the liver, be aided with nourish heart, calm the nerves, spleen invigorating, or have the product such as purging liver-fire concurrently, the consideration of the rarer pathogenesis from depression of liver-QI, insufficiency of the spleen phlegm-damp.Chinese medicine composition provided by the invention emphasizes spleen and stomach function on soothing the liver basis, warm cool combination, using medicines of both cold and hot natures simultaneously, and deficiency and excess combines, QI and blood use, and turbid caused unfavorable, the refreshing machine of clear key of spleen damp-phlegm more paid close attention to after stagnation of liver-QI is malfunctioning.
3, confirm through clinical trial and zoopery, the little medicine in the Chinese medicine composition side of having provided by the invention is special, and giving consideration to both the incidental and fundamental, applies convenient feature, and clinical application effect is remarkable, is better than prior art.And side effect is little, better tolerance, meets the psychological goal of the most of patients with depression Drug therapy of China, improves the compliance of patient treatment, has a extensive future.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: the Chinese medicine composition of Cure of depression and pill thereof
1, raw material: Rhizoma Acori Graminei 30g, Radix Curcumae 30g, Radix Panacis Quinquefolii 30g, Herba Hyperici Monogyni 30g.
2, preparation method:
1) raw materials of traditional Chinese medicinal materials is taken according to above-mentioned consumption;
2) by dry for above-mentioned raw materials Chinese crude drug, be ground into fine powder, sieve, obtain Chinese medicine composition;
3, honeyed pill: add refined honey 50g in the fine powder 50g of Chinese medicine composition, honey during described refined honey is preferably, fully mixes, and makes into soft or hard and is suitable for, pill.
Embodiment 2: the Chinese medicine composition of Cure of depression and pill thereof
1, raw material: Rhizoma Acori Graminei 30g, Radix Curcumae 30g, Radix Panacis Quinquefolii 20g, Herba Hyperici Monogyni 20g.
2, preparation method:
1) raw material Chinese medicine is taken according to above-mentioned consumption, for subsequent use;
2) get appropriate containers, above-mentioned raw materials is put into container and soak 30 minutes, water consumption is 6 times amount of Chinese medicine gross weight, then decocts 2 hours, filters, decoct, second time water consumption is 4 times amount of Chinese medicine gross weight, decocts 1.5 hours, filters again, merge twice filtrate, concentrated, dry, to obtain final product.
3, honeyed pill: add refined honey 45g in the fine powder 50g of Chinese medicine composition, honey during described refined honey is preferably, fully mixes, and makes into soft or hard and is suitable for, pill.
Embodiment 3: the Chinese medicine composition of Cure of depression and pill thereof
1, raw material: Rhizoma Acori Graminei 20g, Radix Curcumae 20g, Radix Panacis Quinquefolii 10g, Herba Hyperici Monogyni 10g.
2, preparation method:
1) raw materials of traditional Chinese medicinal materials is taken according to above-mentioned consumption;
2) by dry for above-mentioned raw materials Chinese crude drug, be ground into fine powder, sieve, obtain Chinese medicine composition;
3, honeyed pill: add refined honey 60g in the fine powder 50g of Chinese medicine composition, honey during described refined honey is preferably, fully mixes, and makes into soft or hard and is suitable for, pill.
Comparative example 1:
With reference to the embodiment 7 of CN200910059522.8 (CN101590207A), i.e. Radix Curcumae 30g, Herba Hyperici Monogyni 30g, Rhizoma Acori Graminei 20g, Fructus Tribuli 20g, this patent is write exactly can soak by water, but there is no concrete grammar, therefore, carry out soak by water according to the method for the embodiment of the present invention 2.
Experimental example 1: zoopery
1, laboratory animal
Cleaning grade healthy adult male SD rat, body weight 180-200g, is provided by Military Medical Science Institute's Experimental Animal Center, animal quality certification SCXK-2012-0001.
2, method for building animal model
Adopt 21 days chronic imprevisions stress (chronic unpredict stress, CUS) method establishment rat depression model, except normal group, the all single cage of administration group and model group rats is raised, chronic stress method is specific as follows: will press from both sides tail, normal-temperature water swimming (23 DEG C, 15min), frozen water swimming (12 DEG C, 5min), illumination all night (24h), water (24h) is prohibited in fasting, wet bedding and padding (24h), totally 6 kinds stimulate random arrangement in 21d, every day a kind, often kind stimulates at least appearance 2 times, homologous stimulus can not occur continuously, make animal can not expect stimulate generation give continuously 21 days stress, cause chronic stress depression model.Normal group do not accept any stress.
3, experiment grouping
After adaptability raises 7 days, carry out the experiment of spacious field, reject horizontal and vertical activity total score lower than 10 rat, then be divided into 6 groups at random, i.e. Normal group, model control group, comparative example 1 group of (sertraline hydrochloride sheet, Pfizer company produces (the accurate word H10980141 of traditional Chinese medicines), 50mg/ sheet, given low 4.5mg/kg), comparative example 2 groups of (XIAOYAO POWDER, formula is Radix Bupleuri 15g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba 15g, Rhizoma Atractylodis Macrocephalae 15g, Poria 15g, Radix Glycyrrhizae Preparata 7.5g, Rhizoma Zingiberis Recens 5g, Herba Menthae 5g, gavage crude drug dosage 8.3g/kg), comparative example 3 groups (adopts the Chinese medicine composition that comparative example 1 provides, given low 8.3g/kg), embodiment 1 group (gavage crude drug dosage 8.3g/kg), embodiment 2 groups (gavage crude drug dosage 8.3g/kg), embodiment 3 groups (gavage crude drug dosage 8.3g/kg), often organize 10.
4, medication
Embodiment 1 group, comparative example 2 groups and comparative example 3 groups give corresponding Compatible Granule, and purchased from Beijing Kangrentang Medicine Co., Ltd (the granule preparation that whole part extracts), suspension oral gavage, every day 1 time, gives 21 days continuously.
Comparative example 1 group gives sertraline hydrochloride suspension oral gavage, every day 1 time, successive administration 21 days.
Model group administration time and approach, with Chinese drug-treated group and Western medicine group, replace medicinal liquid with distilled water.
5, observation index
5.1 rat body weight changes
5.2 sucrose solution preference experiments
All rats carry out the experiment of sucrose solution preference in before modeling and after modeling the 22nd day.Animal puts into sucrose water and 1 bottle of common drinking water of 1 bottle 1% after water 20h is prohibited in fasting, and 2 bottles of positions are random, observes its liquid-consumed amount in 1h, gets rid of the liquid-consumed amount caused by drinking bottle water clock.Calculate sucrose solution preference=sucrose solution consumption/always liquid-consumed × 100%.
5.3 spacious field experiments
Test spacious case apparatus used to be made up of opaque timber, bottom surface is the square of 100 × 100cm and is divided into 25 equilateral grids, and be around the wooden wall of high 40cm, field chamber interior wall fills black paint vehicle.Before experiment and after modeling, the 22nd afternoon 14:00-18:00 carries out this experimental observation in quiet room.After the experiment of sucrose solution preference terminates, rat is put into center grid, observation rat passes through lattice number in 3min, and (4 pawls all enter grid and just count, for horizontal movement score) (2 fore paws soar or seek connections with wall rear number of times, for the score that moves both vertically), every rat only carries out 1 mensuration, and after mensuration, thoroughly clean spacious case carries out next only observation again.
6, experimental result
6.1 rat body weight result of variations: in table 1
Table 1 rat body weight change (g)
| Group | Body weight (0w) | Body weight (1w) | Body weight (2w) | Body weight (3w) |
| Normal group | 184.3±5.8 | 225.8±12.0 | 261.9±10.7 | 317.0±14.8 |
| Model group | 183.4±9.0 | 212.4±16.8 | 220.5±29.1 ++ | 234.0±38.8 ++ |
| Comparative example 1 group | 183.5±7.8 | 228.6±14.9 | 258.4±19.4 * | 301.5±19.2 ** |
| Comparative example 2 groups | 180.8±13.7 | 222.5±18.3 | 236.8±25.2 | 268.7±28.1 * |
| Comparative example 3 groups | 181.9±13.2 | 225.0±11.8 | 244.1±21.6 | 272.6±30.1 * |
| Embodiment 1 group | 180.6±10.0 | 220.3±10.9 | 249.9±21.3 * | 308.1±22.0 ** |
| Embodiment 2 groups | 182.5±11.4 | 227.9±15.2 | 247.8±17.6 | 302.5±16.6 ** |
| Embodiment 3 groups | 183.1±8.9 | 224.7±10.8 | 242.0±20.3 | 298.7±27.1 ** |
Note: compare with normal group
+p<0.05,
++p<0.01; Compare with model group
*p<0.05,
*p<0.01.
Table 1 result shows: the body weight no difference of science of statistics of each group rat before modeling.Through 21 days chronic stresses, compare with normal group, model group rats body weight significantly reduces (P<0.01); Compare with model group, after each group of embodiment and comparative example 1 group of intervention, stress rats body weight significantly improves (P<0.01), and after comparative example 2 groups, 3 groups of interventions, rat body weight is also significantly increased (P<0.05).And compared with comparative example 2 groups, 3 groups, after embodiment 1 group, 2 groups, 3 groups interventions, body weight improves (P<0.05).
6.2 sucrose solution preference test results: in table 2
Table 2 sucrose solution preference is tested
Note: compare+P<0.05 with normal group, ++ P<0.01; * P<0.05 is compared, * * P<0.01 with model group.
Table 2 result shows: the sucrose solution preference rate no difference of science of statistics of each group rat before modeling.After 21 days chronic stresses, compare with normal group, model group rats sucrose solution preference rate significantly reduces (P<0.01); Compare with model group, after embodiment 1 group, comparative example 1 group of intervention, the sucrose solution preference rate of stress rats significantly improves (P<0.01), the sucrose solution preference rate of embodiment 2,3 groups of rats also significantly improves (P<0.05), though though and comparative example 2 groups, 3 groups intervene after sucrose solution preference rate also have part to improve, difference does not reach statistical significance (P > 0.05)
6.3 rat spacious field experimental results: in table 3
The spacious field experiment of table 3 rat
| Group | Total distance | Center percentage ratio (%) | Enter center number of times |
| Normal group | 4749.1±835.3 | 22.6±12.7 | 9.1±3.2 |
| Model group | 3834.2±588.1 + | 6.3±4.3 ++ | 3.4±2.1 ++ |
| Comparative example 1 group | 4616.4±499.6 * | 14.1±8.7 * | 7.8±3.5 * |
| Comparative example 2 groups | 4235.8±773.1 | 12.1±6.8 | 5.4±3.8 |
| Comparative example 3 groups | 4144.5±649.1 | 10.7±12.8 | 5.1±4.5 |
| Embodiment 1 group | 4606.0±638.5 * | 16.2±8.1 * | 7.6±3.8 * |
| Embodiment 2 groups | 4503±631.9 | 15.8±5.8 | 7.1±2.9 |
| Embodiment 3 groups | 4492±711.8 | 15.2±7.2 | 6.9±4.1 |
Note: compare with normal group
+p<0.05,
++p<0.01; Compare with model group
*p<0.05,
*p<0.01.
Table 3 result shows: after 21 days chronic stresses, compare with normal group, the total distance of motion of model group rats obviously reduces (P<0.05), enters center percentage ratio and number of times all significantly reduces (P<0.01); Compare with model group, comparative example 1 group and each group of embodiment significantly improve the total distance of motion, enter center percentage ratio and number of times (P<0.05).Though and comparative example 2 groups, 3 groups in the total distance of motion with enter center percentage ratio and also have part to improve, difference does not reach statistical significance (P > 0.05).
7, experiment conclusion
As can be seen from rat body weight, sucrose solution consumption experiment, the experiment of spacious field, improving in depressive emotion, embodiment respectively organize with comparative example 1 group, 2 groups, 3 groups all can improve rat depressive emotion, and embodiment respectively organizes comparatively comparative example 2 groups, 3 groups of better effects if.
Therefore, can find from zoopery, embodiments of the invention group can reach the curative effect of current antidepressant Western medicine in the curative effect for the treatment of depression, and is better than prior art.
Experimental example 2: clinical trial
1, patient enters group standard:
1.1 ages: 30-65 one full year of life, men and women;
1.2 with reference to " ICD-10 spirit is classified with behavior disorder " (World Health Organization (WHO) compiles, People's Health Publisher, nineteen ninety-five) Diagnosis of Depression.Meet wherein minor depressive outbreak, modest depression outbreak diagnostic point;
1.317 points of < HAMD (17)≤24 points;
There is except 1.4 the severe physical Diseases such as the heart, brain, liver, kidney;
The severe psychiatric diseases such as bipolar affective disorder, schizophrenia symptom except 1.5.
2, test grouping:
Comparative example 3 groups and embodiment 1 group (be in experimental example 1 and refer to), wherein comparative example 3 group of 33 example, embodiment 1 group of 33 example.
3, test method:
All patients derive from Beijing University of Traditional Chinese Medicine Subsidiary Dongfang Hospital's encephalopathy two section outpatient clinic patient in May ,-2014 in May, 2013, side based on the prescription of comparative example 3, embodiment 1 is adopted to treat, adopt Compatible Granule (Beijing Kangrentang Medicine Co., Ltd) day 1 dose, take after mixing it with water at twice; Further consultation once weekly, contrasts symptom, and carry out HAMD detection, carries out record to side reaction, carries out six weeks altogether.
4, efficacy assessment standard:
Effective: symptom total mark reduces >=50%;
Take a turn for the better: symptom total mark reduces >=30%, < 50%;
Invalid: symptom total mark reduces < 30%.
Total effective rate=effective+improvement.
Note: computing formula (nimodipine method): deduction rate=[before (before treatment the rear total mark of total mark-treatment) ÷ treatment total mark] × 100%
5, result of the test:
The front two groups of state of an illness distribution situations of 5.1 treatment: in table 5
Table 5 liang group: HAMD integral distribution situation
| Group | Number of cases | Slightly (> 17 points) | Moderate (> 25 points) | Severe (> 35 points) |
| Comparative example 3 groups | 33 | 29 | 4 | 0 |
| Embodiment 2 groups | 33 | 28 | 5 | 0 |
Table 5 result shows: selected patients 66 example all belongs to patients with depression in various degree, no significant difference between state of an illness distribution situation two groups.
Before and after 5.2 liang of group treatments, HAMD scoring is compared: in table 6
Before and after table 6 liang group treatment, HAMD scoring is compared
Note: with this group before treatment ,+P<0.05, ++ P<0.01
Table 6 result shows: after treatment, significant difference (P < 0.05) all appears in two groups of scorings with this group before treatment, wherein embodiment 1 group and this group treat before there were significant differences (P < 0.01), treat afterwards embodiment 1 group comparatively comparative example 3 groups of differences have statistical significance (P < 0.05).
5.3 liang of group effective percentage compare: in table 7
Table 7: two groups of effective percentage compare
| Group | Number of cases | Effective | Take a turn for the better | Invalid | Total effective rate |
| Comparative example 2 groups | 33 | 8 | 19 | 6 | 81.8％ |
| Embodiment 2 groups | 33 | 10 | 20 | 3 | 90.9％ |
6, result display:
The total effective rate of comparative example 3 is 81.8%, has certain therapeutic effect; And embodiments of the invention 2 total effective rate is greater than 90%.
7, untoward reaction aspect: comparative example 3 groups and embodiment 2 groups, do not occur untoward reaction at treatments period, do not occur the gastrointestinal symptoms such as Nausea and vomiting, asymptomatic sharp deterioration case yet.
Conclusion: all find from the test of animal Experiment and clinic presentations, adopt square Cure of depression symptom based on Chinese medicine composition provided by the invention evident in efficacy, and be better than prior art.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (10)
1. a Chinese medicine composition for Cure of depression, it is made up of following Chinese medicine: Rhizoma Acori Graminei, Radix Curcumae, Radix Panacis Quinquefolii, Herba Hyperici Monogyni.
2. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Acori Graminei 10-30 part, Radix Curcumae 10-30 part, Radix Panacis Quinquefolii 10-30 part, Herba Hyperici Monogyni 10-30 part.
3. Chinese medicine composition according to claim 2, is characterized in that, described Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Acori Graminei 20-30 part, Radix Curcumae 20-30 part, Radix Panacis Quinquefolii 20-30 part, Herba Hyperici Monogyni 20-30 part.
4. Chinese medicine composition according to claim 3, is characterized in that, described Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Acori Graminei 30 parts, Radix Curcumae 30 parts, Radix Panacis Quinquefolii 20-30 part, Herba Hyperici Monogyni 20-30 part.
5. Chinese medicine composition according to claim 4, is characterized in that, described Chinese medicine composition is made up of the Chinese medicine of following weight portion: Rhizoma Acori Graminei 30 parts, Radix Curcumae 30 parts, Radix Panacis Quinquefolii 30 parts, Herba Hyperici Monogyni 30 parts.
6. prepare a method for the Chinese medicine composition described in any one of claim 1-5, it is characterized in that, the method comprises the following steps: take each composition according to proportioning, then pulverize, to obtain final product.
7. prepare the method for the Chinese medicine composition described in any one of claim 1-5 for one kind, it is characterized in that, the method comprises the following steps: take Rhizoma Acori Graminei, Radix Curcumae, Radix Panacis Quinquefolii and Herba Hyperici Monogyni according to proportioning, and with soak by water 2-3 time, each water consumption is the 2-8 times amount of Chinese medicine gross weight, each decocting time is 0.5-2 hour, and twice decocting liquid, filter, concentrated, drying, to obtain final product.
8., containing the preparation of the Chinese medicine composition described in any one of claim 1-5, it is characterized in that, said preparation is made up separately of Chinese medicine composition or is formed by with Chinese medicine composition and pharmaceutically acceptable carrier.
9. preparation according to claim 8, is characterized in that, described preparation is oral formulations, and described oral formulations is preferably tablet, pill, powder, capsule, oral liquid, granule or health tea.
10. the Chinese medicine composition described in any one of claim 1-5 or the preparation described in claim 8 or 9 application in the medicine preparing Cure of depression.
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