CN101590207A - A kind of medicine for the treatment of depression and preparation method thereof - Google Patents
A kind of medicine for the treatment of depression and preparation method thereof Download PDFInfo
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- CN101590207A CN101590207A CNA2009100595228A CN200910059522A CN101590207A CN 101590207 A CN101590207 A CN 101590207A CN A2009100595228 A CNA2009100595228 A CN A2009100595228A CN 200910059522 A CN200910059522 A CN 200910059522A CN 101590207 A CN101590207 A CN 101590207A
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- rhizoma acori
- acori graminei
- radix curcumae
- herba hyperici
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Abstract
The invention discloses a kind of pharmaceutical composition for the treatment of depression, it is to be the Chinese medicine preparation that primary raw material is prepared from Radix Curcumae, Herba Hyperici Monogyni, Fructus Tribuli, Rhizoma Acori Graminei.It is simple, unique that the present invention writes out a prescription, and low price is evident in efficacy.Through clinical research confirmation, this medicine can obviously improve the clinical symptoms of depression, reduces Hamilton depressive scale (HAM-D) scoring, and total effective rate is 84%.The invention also discloses the preparation method of the above medicine, according to the different qualities of every flavor Chinese medicine, with after the pretreatment such as different solvents extraction, formulated in proportion respectively.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of depression.Be the Chinese patent medicine that primary raw material is prepared from Radix Curcumae, Herba Hyperici Monogyni, Fructus Tribuli, Rhizoma Acori Graminei specifically.The invention still further relates to manufacturing method for above mentioned medicine.
Background technology
Depression is called as " blue secret worry " in the west, show that according to relevant investigation the depression sickness rate is about 3%-5% in China, and the patient has surpassed 2,600 ten thousand people at present.The principal character of depressive symptom is that emotion (mental state) is low, and it often many simultaneous phenomenons can also occur, and common has: 1. to daily routines forfeiture interest, do not have happy sense; 2. energy obviously goes down, causeless lasting tired sense; 3. psychomotor activity is sluggish or intense; 4. self evaluation is low excessively, or self-accusation, or feeling of guilt is arranged, and can reach the vain hope degree; 5. association difficulty, or conscious elaborative faculty significantly descends; 6. occur the thought of wanting to die repeatedly, or suicide is arranged; 7. insomnia, or early awakening, or hypersomnia; 8. inappetence, or body weight obviously alleviates; 9. libido obviously goes down.If people the listless while occurs during with four in the above-mentioned symptom, just can determine that there has been depressive symptom in patient.The treatment of depression has multiple mode, based on Drug therapy.At present commonly used for 1. tricyclic antidepressants (TCA) as imipramine, amitriptyline, the equality of worrying too much; 2. five hydroxytryptamine reuptake inhibitor (SSRI) is as fluoxetine, Sertraline, paroxetine, fluvoxamine etc., depression there is sure curative effect, total effective rate is about about 70%, but onset time is slower, and this type of medicine side reaction is extensively as xerostomia, constipation, blurred vision, dysuria, tachycardia, unable, dizzy, heart block etc.Therefore, the Chinese medicine preparation of depression is treated in exploitation, has a extensive future, though research at present has the Chinese patent medicine of some treatment depressions, but still can not satisfy patient's needs, and its prescription composition is all complicated, and flavour of a drug are more, and price is higher, unsatisfactory curative effect.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine and corresponding preparations thereof for the treatment of the depression determined curative effect.Its characteristics have: can obviously improve patient's depressive symptom, and low price, have no side effect.
Solution of the present invention is based on the pathogenetic understanding of motherland's medical science to depression, and motherland's medical science is classified as it " strongly fragrant disease " category, and pathogenic factor and depression of liver-QI, the expectorant stasis of blood cover that to close thinking relevant.According to oneself clinical experience for many years, from numerous Chinese medicines, determine the effective Chinese medicine of a series of treatment depressions earlier, through clinical checking repeatedly, screen compound Chinese medicinal preparation again.Has regulating qi to disperse stagnation, effects such as waking up the patient from unconsciousness by dissipating phlegm.Can obviously improve patient's depressive symptom, and low price, have no side effect.
The present invention is a kind of pharmaceutical composition for the treatment of depression, it is characterized in that it comprises: Radix Curcumae 10～50%, Herba Hyperici Monogyni 10～50%, Fructus Tribuli 10～30%, Rhizoma Acori Graminei 10～30%.
Medicine composition of the present invention can also contain one or more in the Chinese medicines such as Radix Bupleuri, Herba Centellae.
Medicine of the present invention can be the medicine of said dosage form on any pharmaceutics.
The preparation of this medicine can prepare by the conventional method on the various medicaments, as:
Radix Curcumae, Herba Hyperici Monogyni, Fructus Tribuli, Rhizoma Acori Graminei extract according to a conventional method with ethanol or water etc., concentrate, and drying gets extract, makes the medicine of required dosage form.
In the above preparation process, if necessary, can add adjuvant commonly used in an amount of pharmaceutics, as starch, dextrin, microcrystalline cellulose, amylum pregelatinisatum, magnesium stearate, micropowder silica gel, sucrose, carboxymethyl starch sodium etc.
For showing clinical effectiveness of the present invention, select 20～60 years old, be diagnosed as patient's 62 examples of depression, diagnostic criteria is by Chinese mental sickness classification schemes and diagnostic criteria (CCMD-2-R) and 17 the Hamilton depression scale standard ratings (HAM-D) carried out in 1994, the course of disease 5 months～7 years.Random packet is carried out observation of curative effect.Chinese medicine preparation group (treatment group) 32 examples, male 24 examples, women 8 examples, 42 ± 8 years old age; Prozac group (matched group) 30 examples, man's 20 examples, woman's 10 examples, at 41 ± 10 years old age, two groups of age differencess do not have significance (P＜0.05), two groups of case history of past illnesies and disease accompanied integration are close, all carry out history-taking when going into to organize, physical examination and laboratory inspection, all cases that still unstabilized physical disease or other mental sickness are arranged, all give eliminating, do not take any psychotropic drugs after going into to organize.
Therapeutic Method: the treatment group gives Chinese medicine preparation 15g/ day, divide 3 times oral; Matched group gives prozac 20mg/ day, and equal 6 weeks are 1 course of treatment.
Efficacy determination: efficacy determination is used Hamilton depressive scale (HAM-D) scoring, and 17 HAM-D are divided into slightly (≤17 minutes) with patient, moderate (18～24 minutes), and severe (〉=24 minutes) ,≤7 are divided into no depressive symptom.Change is divided into therapeutic outcome according to the HAM-D total points: (1) is almost recovered: scoring reduces 91%～100%; (2) marked improvement: scoring reduces 46%～90%; (3) progressive: scoring reduces 19%～45%; (4) worsen: scoring does not have minimizing or increases in 18%, and statistical analysis adopts x
2Check.
Result: treatment 6 week back treatment group cure rate 28.1% (9/32), obvious effective rate (marked improvement and progress) 56.3% (18/32), total effective rate 84.4%, matched group cure rate 33.3% (10/30), obvious effective rate 46.7% (14/30), total effective rate 80%.Two groups of cure rate difference not statistically significants (P＞0.05), but matched group has 5 routine patients symptoms such as nauseating and diarrhoea to occur, and the treatment group does not have tangible untoward reaction.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
Medicine of the present invention can be made up of and different proportion relations multiple heterogeneity, as (consumption is weight percentage):
(1) Radix Curcumae 50 Herba Hyperici Monogynis 10 Rhizoma Acori Graminei 10 Fructus Tribulis 30
(2) Radix Curcumae 40 Herba Hyperici Monogynis 20 Rhizoma Acori Graminei 15 Fructus Tribulis 25
(3) Radix Curcumae 40 Herba Hyperici Monogynis 30 Rhizoma Acori Graminei 10 Fructus Tribulis 20
(4) Radix Curcumae 40 Herba Hyperici Monogynis 30 Rhizoma Acori Graminei 15 Fructus Tribulis 15
(5) Radix Curcumae 40 Herba Hyperici Monogynis 40 Rhizoma Acori Graminei 10 Fructus Tribulis 10
(6) Radix Curcumae 30 Herba Hyperici Monogynis 40 Rhizoma Acori Graminei 15 Fructus Tribulis 15
(7) Radix Curcumae 30 Herba Hyperici Monogynis 30 Rhizoma Acori Graminei 20 Fructus Tribulis 20
(8) Radix Curcumae 20 Herba Hyperici Monogynis 40 Rhizoma Acori Graminei 15 Fructus Tribulis 25
(9) Radix Curcumae 20 Herba Hyperici Monogynis 50 Rhizoma Acori Graminei 20 Fructus Tribulis 10
(10) Radix Curcumae 10 Herba Hyperici Monogynis 50 Rhizoma Acori Graminei 30 Fructus Tribulis 10
(11) Radix Curcumae 30 Herba Hyperici Monogynis 20 Rhizoma Acori Graminei 10 Fructus Tribulis 10 Herba Centellaes 20 Radix Bupleuri 10
The preparation method of medicine of the present invention, can be with reference to following method:
(1) Radix Curcumae, Herba Hyperici Monogyni, Fructus Tribuli, Rhizoma Acori Graminei water are pressed decocting method and extracted, concentrate, drying gets extract, adds appropriate amount of starch, granulates, and is processed into granule.
(2) with the Herba Hyperici Monogyni alcohol reflux, reclaim solvent, get extract; With Radix Curcumae,, Fructus Tribuli, Rhizoma Acori Graminei water press decocting method and extract, concentrate, extract, mixes with extract of hypericum perforatum, drying, tablet is processed in granulation.
(3) Radix Curcumae, Herba Hyperici Monogyni, Fructus Tribuli, Rhizoma Acori Graminei water are pressed decocting method and extracted, concentrate, drying is granulated, and is processed into tablet.
(4) with the Herba Hyperici Monogyni alcohol reflux, reclaim solvent, get extract; With Radix Curcumae,, Fructus Tribuli, Rhizoma Acori Graminei water press decocting method and extract, concentrate, extract, mixes with extract of hypericum perforatum, drying, capsule is processed in granulation.
(5) Radix Curcumae, Herba Hyperici Monogyni, Fructus Tribuli, Rhizoma Acori Graminei water are pressed decocting method and extracted, concentrate, drying is granulated, and is processed into capsule.
And for example, consumption consists of Radix Curcumae 30 Herba Hyperici Monogynis 20 Rhizoma Acori Graminei 10 Fructus Tribulis 10 Herba Centellaes 20 Radix Bupleuri 10 capsules, and its preparation method is:
Herba Hyperici Monogyni, Herba Centellae are used alcohol reflux, reclaim solvent, get alcohol extract; Radix Curcumae, Radix Bupleuri, Fructus Tribuli, Rhizoma Acori Graminei water are pressed decocting method extract, concentrate, get water extract, mix with alcohol extract, drying is granulated, and is processed into capsule.
Claims (7)
1. a medicine for the treatment of depression is characterized in that it is to be made by following raw materials by weight proportions: Radix Curcumae 10～50%, Herba Hyperici Monogyni 10～50%, Fructus Tribuli 10～30% and Rhizoma Acori Graminei 10～30%.
2. medicine according to claim 1 is characterized in that each drug weight ratio range is in the crude drug: Radix Curcumae 20～45%, Herba Hyperici Monogyni 20～45%, Fructus Tribuli 15～25% and Rhizoma Acori Graminei 10～25%.
3. medicine according to claim 2 is characterized in that each drug weight ratio range is in the crude drug: Radix Curcumae 25～40%, Herba Hyperici Monogyni 25～35%, Fructus Tribuli 15～20% and Rhizoma Acori Graminei 15～20%.
4. medicine according to claim 3 is characterized in that each drug weight ratio range is in the crude drug: Radix Curcumae 40%, Herba Hyperici Monogyni 30%, Fructus Tribuli 15% and Rhizoma Acori Graminei 15%.
5. medicine according to claim 1, medicine composition of the present invention can also contain one or more in the Chinese medicines such as Radix Bupleuri, Herba Centellae.
6. according to each described medicine in the claim 1 to 5, it is characterized in that the dosage form of said medicine is selected from granule or tablet or capsule.
7. the method for preparing each described medicine in the claim 1 to 5, it is characterized in that: Radix Curcumae, Herba Hyperici Monogyni, Fructus Tribuli, Rhizoma Acori Graminei, Radix Bupleuri, Herba Centellae water or Different concentrations of alcohol solution are extracted according to a conventional method, then each extract is mixed evenly, make the medicine of required dosage form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CNA2009100595228A CN101590207A (en) | 2009-06-08 | 2009-06-08 | A kind of medicine for the treatment of depression and preparation method thereof |
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| CNA2009100595228A CN101590207A (en) | 2009-06-08 | 2009-06-08 | A kind of medicine for the treatment of depression and preparation method thereof |
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| CN101590207A true CN101590207A (en) | 2009-12-02 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606636A (en) * | 2015-01-29 | 2015-05-13 | 北京中医药大学东方医院 | Traditional Chinese medicine composition for treating depression and preparation method thereof |
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2009
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606636A (en) * | 2015-01-29 | 2015-05-13 | 北京中医药大学东方医院 | Traditional Chinese medicine composition for treating depression and preparation method thereof |
| CN104606636B (en) * | 2015-01-29 | 2018-03-06 | 北京中医药大学东方医院 | A kind of Chinese medicine composition for treating depression and preparation method thereof |
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Open date: 20091202 |