CN102648976B - Medicine for delaying chronic renal failure - Google Patents
Medicine for delaying chronic renal failure Download PDFInfo
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- CN102648976B CN102648976B CN2012101226788A CN201210122678A CN102648976B CN 102648976 B CN102648976 B CN 102648976B CN 2012101226788 A CN2012101226788 A CN 2012101226788A CN 201210122678 A CN201210122678 A CN 201210122678A CN 102648976 B CN102648976 B CN 102648976B
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Abstract
The invention discloses a medicine for delaying chronic renal failure. The medicine for delaying chronic renal failure is prepared from the following components in part by weight: 25-36 parts of radix astragali, 5-12 parts of tangerine peel, 10-15 parts of Rhizoma Pinelliae, 10-20 parts of Poria cocos, 10-15 parts of fructus amomi, 10-20 parts of Codonopsis pilosula, 3-20 parts of dried ginger, 7-23 parts of Coptis, 5-12 parts of cardamom seeds, 25-31 parts of red-rooted salvia, 10-17 parts of rhubarb, 16-28 parts of Rehmannia, 9-15 parts of yam, 10-15 parts of cornus, 2-10 parts of fried licorice, 9-15 parts of Poria cocos, 10-30 parts of dandelion and 6-15 parts of betel nut. Through a synergistic effect of various components in the compound prescription, the orally taken medicine for delaying progression of the chronic renal failure has the functions of tonifying the spleen, nourishing the kidney, harmonizing the stomach, removing the dampness, eliminating turbidity, detoxifying, benefiting Qi, activating blood circulation and the like and has obvious effects on deficiency of spleen and kidney, internal existence of wetness and turbidity, stasis of toxin and evils, obstruction of blood vessels and veins and the like caused by the chronic renal failure.
Description
Technical field
The present invention relates to a kind of medicine of delaying chronic kidney exhaustion disease progression for oral administration
Background technology
Chronic renal failure (CRF) is the clinical syndrome by the complexity that various chronic kidney disease continue progress, a large amount of nephronlosses of irreversibility due to increasing the weight of and various metabolism disorder form.Main morphological change is the fibrosis of glomerular sclerosis, renal tubular interstitium etc.It will carry out sexual development to end stage renal failure with friction speed.Its main manifestations is the toxic metabolite retention, water, electrolyte, acid base imbalance, and the infringement of whole body multisystem.Chronic renal failure is the major disease of serious harm human health, and its sickness rate is sustainable growth trend in the world.Though the population of China prevalence does not have definite data statistics, it also increases year by year.According to Mount Huang meeting summary in 1992, chronic renal failure is divided into: 1. renal function of compensatory phases 2. of renal function loses 4. Uremic of compensatory phases 3. renal failure stages (Uremic), its Therapeutic Principle is: 1. the Preventing Countermeasures of morning, noon and afternoon CRF and measure: 1) in time, effectively control hypertension, 2) the property feature of ACEI and ARB, 3) strictly control blood glucose, 4) control albuminuria, 5) dietetic therapy; 2.CRF nutrition treatment; 3. Drug therapy: 1) correct acidosis and water, electrolyte disturbance: a and correct metabolic acidosis, the control of b water sodium disorder, the treatment of c hyperpotassemia.2) hypertensive treatment, the 3) treatment of anemia and the application of erythropoietin, 4) hypocalcemia, 5) control is infected, the 6) treatment of hyperlipemia, 7) oral adsorbent method and catharsis therapy, 8) other; 4. uremia's alternative medicine: 1, hemodialysis, 2, peritoneal dialysis, 3, renal transplantation.In a word, to the various symptomatic treatments of chronic renal failure, take and delay it and proceed to end stage renal failure as maximum target, to hope the life quality that improves the patient, reduce uremia's replacement therapy and reduce medical expense, and finally reduce its case fatality rate.
Summary of the invention
The object of the present invention is to provide a kind of medicine for chronic renal function failure patients delaying chronic kidney hypofunction for oral administration.
For achieving the above object, the technical solution of employing is in the present invention:
The medicine of delaying chronic kidney hypofunction, made by the raw material of following weight parts: Radix Astragali 25-36, Pericarpium Citri Reticulatae 5-12, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10-15, Poria 10-20, Fructus Amomi 10-15, Radix Codonopsis 10-20, Rhizoma Zingiberis 3-20, Rhizoma Coptidis 7-23, KOUREN 5-12, Radix Salviae Miltiorrhizae 25-31, Radix Et Rhizoma Rhei 10-17, Radix Rehmanniae Preparata 16-28, Rhizoma Dioscoreae 9-15, Fructus Corni 10-15, Radix Glycyrrhizae Preparata 2-10, Poria 9-15, Herba Taraxaci 10-30, Semen Arecae 6-15.
Further, the medicine of delaying chronic kidney hypofunction, made by the raw material of following weight parts: the Radix Astragali 30, Pericarpium Citri Reticulatae 10, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 12, Poria 15, Fructus Amomi 13, Radix Codonopsis 15, Rhizoma Zingiberis 13, Rhizoma Coptidis 17, KOUREN 10, Radix Salviae Miltiorrhizae 27, Radix Et Rhizoma Rhei 14, Radix Rehmanniae Preparata 22, Rhizoma Dioscoreae 13, Fructus Corni 12, Radix Glycyrrhizae Preparata 7, Poria 12, Herba Taraxaci 20, Semen Arecae 12.
The present invention selects the Radix Astragali, Pericarpium Citri Reticulatae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Poria, Fructus Amomi, Radix Codonopsis, Rhizoma Zingiberis, Rhizoma Coptidis, KOUREN, Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Radix Glycyrrhizae Preparata, Poria, Herba Taraxaci, Semen Arecae kinds of traditional Chinese medicines to make decoction or granule.Wherein: the Radix Astragali, sweet tepor, return the Liver and kidney warp, and nourishing YIN and supplementing blood, beneficial essence are filled out marrow, for the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat seminal emission, interior-heat are quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair.Pericarpium Citri Reticulatae, the toil temperature, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Xin Wen, poisonous, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass,, globus hystericus vexed for abundant expectoration cough with asthma, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache, vomiting regurgitation, phlegm retention vertigo and palpitation, breast gastral cavity painful abdominal mass etc., multiplex in stopping nausea and vomiting by lowering the adverse flow of QI.Poria, sweet light flat, promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool have loose bowels, irritability, palpitation with fear insomnia.Fructus Amomi, Xin Wen, removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortively,, Deficiency and coldness of spleen and stomach not hungry for turbid damp obstructing in middle-JIAO, wrist painful abdominal mass, vomiting are had loose bowels, pregnancy reactions, frequent fetal movement.Radix Codonopsis, sweet micro-hardship is slightly cold, moistening the lung and resolving phlegm, yin nourishing stomach function regulating, suppressing the hyperactive liver removing toxic substances,, furunculosis skin infection dizzy for cough due to lung-heat, vomiting regurgitation, lack of appetite xerostomia, conjunctival congestion.Rhizoma Zingiberis, hot, warming spleen and stomach for dispelling cold, recuperating depleted YANG are promoted blood circulation, drying dampness to eliminate phlegm, and coldness and pain in the epigastrium, vomiting are had loose bowels, cold extremities faint pulse, phlegm retention are breathed with cough.Rhizoma Coptidis, bitter cold, heat clearing and damp drying, eliminating fire and detoxication, for damp and hot feeling of fullness, vomiting, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tell nosebleed, conjunctival congestion acid regurgitation, have a toothache, quench one's thirst, the carbuncle furuncle.KOUREN, Xin Wen, the removing dampness painful abdominal mass that disappears, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving.Radix Salviae Miltiorrhizae, hardship is slightly cold, stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the relieving restlessness that clears away heart-fire, for menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swell and ache, dysphoria and insomnia, hepatosplenomegaly, angina pectoris.Radix Et Rhizoma Rhei, bitter cold, the logical intestinal that expels the heat-evil, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Radix Rehmanniae Preparata, sweet tepor, return the Liver and kidney warp, and nourishing YIN and supplementing blood, beneficial essence are filled out marrow, for the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair.Rhizoma Dioscoreae, sweet flat, spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Fructus Corni, sour and astringent tepor, liver and kidney tonifying, essence astringing and desertion stemming.Radix Glycyrrhizae Preparata, sweet flat, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, the multiple arteries and veins of invigorating the spleen and replenishing QI, weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.
The compound granular of this kind of delaying chronic kidney exhaustion disease progression for oral administration is by respectively forming the synergism of medicine in compound recipe, there is strengthening spleen, tonifying kidney, stomach function regulating removing dampness, let out the effects such as turbid toxin expelling, benefiting QI for activating blood circulation, to accumulateing in the deficiency of spleen and stomach of chronic renal failure, turbid damp, the poison heresy is detained, and the obstructed grade of blood vessels has remarkable result.
The specific embodiment
Below in conjunction with embodiment, the present invention is described in detail:
Embodiment 1
The medicine of delaying chronic kidney hypofunction, made by the raw material of following weight parts: Radix Astragali 25-36, Pericarpium Citri Reticulatae 5-12, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 10-15, Poria 10, Fructus Amomi 10, Radix Codonopsis 10, Rhizoma Zingiberis 3, Rhizoma Coptidis 7, KOUREN 5, Radix Salviae Miltiorrhizae 25, Radix Et Rhizoma Rhei 10, Radix Rehmanniae Preparata 16, Rhizoma Dioscoreae 9, Fructus Corni 10, Radix Glycyrrhizae Preparata 2, Poria 9, Herba Taraxaci 10, Semen Arecae 6.
Embodiment 2
The medicine of delaying chronic kidney hypofunction, made by the raw material of following weight parts: the Radix Astragali 36, Pericarpium Citri Reticulatae 12, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 15, Poria 20, Fructus Amomi 15, Radix Codonopsis 20, Rhizoma Zingiberis 20, Rhizoma Coptidis 23, KOUREN 12, Radix Salviae Miltiorrhizae 31, Radix Et Rhizoma Rhei 17, Radix Rehmanniae Preparata 28, Rhizoma Dioscoreae 15, Fructus Corni 15, Radix Glycyrrhizae Preparata 10, Poria 15, Herba Taraxaci 30, Semen Arecae 15.
Embodiment 3
The medicine of delaying chronic kidney hypofunction, made by the raw material of following weight parts: the Radix Astragali 30, Pericarpium Citri Reticulatae 10, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 12, Poria 15, Fructus Amomi 13, Radix Codonopsis 15, Rhizoma Zingiberis 13, Rhizoma Coptidis 17, KOUREN 10, Radix Salviae Miltiorrhizae 27, Radix Et Rhizoma Rhei 14, Radix Rehmanniae Preparata 22, Rhizoma Dioscoreae 13, Fructus Corni 12, Radix Glycyrrhizae Preparata 7, Poria 12, Herba Taraxaci 20, Semen Arecae 12.
The manufacture method of the medicine of delaying chronic kidney hypofunction:
Get the Radix Astragali, Pericarpium Citri Reticulatae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Poria, Fructus Amomi, Radix Codonopsis, KOUREN, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Radix Glycyrrhizae Preparata, Poria, Herba Taraxaci, Semen Arecae, add 8 times of water gagings and decoct 2 times, each 1.5 hours, filter, merging filtrate, being evaporated to relative density is 1.05～1.08 (60 ℃), let cool, add ethanol to containing the alcohol amount, reaching 70%, placement is spent the night, and filters, decompression recycling ethanol, and continue to be concentrated into the thick paste that relative density is 1.30～1.35 (60 ℃), drying under reduced pressure, obtain.
Get Rhizoma Zingiberis, Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei decoction piece, add 60% alcohol reflux 2 times, each 1.5 hours, filter, merging filtrate, decompression recycling ethanol, and continue to be concentrated into the thick paste that relative density is 1.30～1.35 (60 ℃), drying under reduced pressure, obtain.
Get above-mentioned two parts of thick pastes, pulverize, cross 80 mesh sieves, add microcrystalline Cellulose, add starch to total amount, mix thoroughly, with 90% ethanol granulation, drying, in flakes, film coating, obtain granule medicament in compacting.
For showing the therapeutic effect of medicine of the present invention, carry out following comparative illustration:
1, clinical data
1. case choice criteria
Inclusive criteria: (1) age was at the sex of 18～65 years old; (2) meet the chronic renal failure diagnostic criteria, it drafts standard in 1993 with reference to " CHINESE JOURNAL OF INTERNAL MEDICINE " editorial board nephropathy special interest group.1. chronic renal failure diagnostic criteria; 2. chronic renal failure clinical stages standard; 3. TCM syndrome diagosis is with reference to the standard of " guideline of clinical investigations of new Chinese medicine treatment chronic renal failure ".(3) differential diagnosis in tcm belongs in prescription with reference to " new Chinese medicine guideline of clinical investigations " and renal failure recovering particles, deficiency of spleen and stomach that function cures mainly formulation, turbid damp and accumulates, and malicious heresy is detained, the obstructed pattern of syndrome of blood vessels.
Exclusion standard: (1) is diagnosed as Acute Renal Failure Patients; (2) peritoneal dialysis and hemodialysis patients; (3) gestation or prepare gestation and age of sucking the female; (3) merge intentionally, the serious diseases such as brain, lung, liver, hemopoietic system, or the patient of the wasting diseasess such as malignant tumor, active tuberculosis is arranged, hepatitis B inspection prompting e antigen positive person, or the renal transplantation latter; (4) psychotic, can not the partner.
2, physical data
The observation case is 2010 03 month and is in hospital and the out-patient to First People's Hospital, economic and technological development zone, 09 month Qingdao in 2011, complete case-data is arranged, totally 130 examples.Adopt the completely randomized design scheme, application table of random number method, the sequencing medical by the patient is divided into granule therapy group 80 examples at random by it, man's 48 examples, female's 32 examples, 18～65 years old age, on average (46.2 ± 12.8) year, the kidney health is injected matched group 50 examples, male 28 examples, female's 22 examples, 19～63 years old age, average (45.0 ± 14.6) year, each organizes Alb, Hb before patient's physical data and treatment, RBC, Scr, BUN level and 24hUpr through harmony relatively, difference there are no significant meaning (P>0.05), have comparability.
3, Therapeutic Method
All patients all adopt the high-quality low protein diet, according to the state of an illness, in conjunction with diuresis, control blood pressure, correct acidosis, and anemia, correct the anti symptom treatment such as calcium and phosphorus metabolism disorder.On above-mentioned treatment basis, treatment group gives the renal failure recovering particles, and warm water is taken after mixing it with water, every day 2 times.The matched group Experimental Study on Shenkang Injection in Treating, 5% glucose injection 250ml+ SHENKANG ZHUSHEYE 60ml intravenous drip, every day 1 time.It within 2 months, is a course for the treatment of.
4, observation index
Clinical symptoms and sign: anemia, weak, inappetence, dim complexion, tongue fur and pulse condition, and limds edema etc., laboratory checking index as: the treatment before and after serum albumin (Alb), hemoglobin (Hb), red blood cell count(RBC) (RBC), serum creatinine (Scr), blood urea nitrogen (BUN) and twenty-four-hour urine protein quantification (24hUpr).
5, therapeutic evaluation
Treat the chronic renal failure guideline of clinical investigations and draft efficacy assessment standard in conjunction with clinical experience with reference to new Chinese medicine in " new Chinese medicine guideline of clinical investigations ".Clinical recovery: clinical symptoms, sign disappear or basic the disappearance, and main physical and chemical index is normal; Produce effects: clinical symptoms, sign are obviously improved, main physical and chemical index normal; Effectively: clinical symptoms, sign all take a favorable turn, main physical and chemical index normal; Invalid: clinical symptoms, sign all are not improved, even increase the weight of.
6, statistical method
Statistical procedures is used the SPSS13.0 statistical package, and all continuous datas first carry out the homogeneity of variance analysis, confirms that variance adopts after neat
Mean, relatively apply the t check in group, ranked data adopt Ridit to analyze, and P<0.05 has been considered as statistical significance.
Therapeutic evaluation
According to certain the standard of curative effect evaluation, Estimating curative effect is: granule therapy group 0 example of fully recovering, produce effects 41 examples, effective 30 examples, no effect 9; Matched group 0 example of fully recovering, produce effects 23 examples, effective 21 examples, invalid 6 examples.
Between two groups, comparing difference is without significance (P>0.05), in Table 1.
Table 1 liang group curative effect relatively
Annotate: compare P>0.05 with matched group.
Table 2 is taken clinical drug symptom of the present invention, sign curative effect relatively
Annotate: there were significant differences for treatment group and matched group comparison total effective rate, P<0.05.
Table 3 is taken Drug therapy of the present invention front and back serum creatinine, blood urea nitrogen and twenty-four-hour urine protein quantification and is changed relatively
Annotate: before two groups of treatments with treatment after between serum creatinine, blood urea nitrogen and twenty-four-hour urine protein quantification relatively there were significant differences P<0.01, two group after treatment result relatively, no significant difference, P>0.05.
Table 4 is taken Drug therapy of the present invention front and back albumin, hemoglobin and red blood cell count(RBC) and is changed relatively
Annotate: before two groups of treatments with treatment after between serum creatinine, blood urea nitrogen and twenty-four-hour urine protein quantification relatively there were significant differences P<0.01, two group after treatment result relatively, no significant difference, P>0.05.
About untoward reaction
Observation period endoparticle treatment group has the reactions such as slight stomach discomfort, times of defecation increase after having some cases to take medicine, suitably reduce dosage or the rear most elimination of taking medicine after meal, can proceed to observe; Kidney health matched group, occasionally have hypercalcemia to occur, and after suitably reducing the intake of vitamin D, can eliminate symptom, proceeds to observe.Groups of grains is 8.75% (7/80); Kidney health 8.00% (4/50), between each group, adverse reaction rate compares, difference not statistically significant, P>0.05.
In sum, above application medicine of the present invention is done treatment to 80 routine patients of chronic renal failures and is observed, obtain significant curative effect, and before and after treatment, Liver and kidney cardiac function and blood biochemical, defecation check, all do not find obvious toxic-side effects, drug administration safety of the present invention is described, to human body nonhazardous effect.
Claims (1)
1. the medicine of delaying chronic kidney hypofunction, is characterized in that, by the raw material of following weight parts, made:
The Radix Astragali 30, Pericarpium Citri Reticulatae 10, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 12, Poria 15, Fructus Amomi 13, Radix Codonopsis 15, Rhizoma Zingiberis 13, Rhizoma Coptidis 17, KOUREN 10, Radix Salviae Miltiorrhizae 27, Radix Et Rhizoma Rhei 14, Radix Rehmanniae Preparata 22, Rhizoma Dioscoreae 13, Fructus Corni 12, Radix Glycyrrhizae Preparata 7, Poria 12, Herba Taraxaci 20, Semen Arecae 12.
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| CN103830466A (en) * | 2012-11-27 | 2014-06-04 | 包桂荣 | Medicine for treating early kidney failure |
| CN105614862A (en) * | 2016-01-22 | 2016-06-01 | 南京贝杉国际贸易有限公司 | Functional food capable of protecting renal function and delaying chronic renal failure process |
| CN107961364B (en) * | 2017-12-06 | 2021-01-26 | 南方医科大学深圳医院 | Traditional Chinese medicine composition for treating chronic renal failure |
| CN115779029A (en) * | 2022-12-23 | 2023-03-14 | 广州市番禺区中医院 | Preparation method of oral nephrosis traditional Chinese medicine decoction with low potassium content |
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| JP2002291439A (en) * | 2001-03-30 | 2002-10-08 | Kinjirushi Wasabi Kk | Food or preparation using spicy material as raw material |
| CN1814124A (en) * | 2005-08-29 | 2006-08-09 | 吴开敏 | Rehmannia-root preparation of nourishing Yin, supplementing kidney and Qi, activating blood circulation |
| CN101396506B (en) * | 2008-10-09 | 2011-01-26 | 刘运波 | Traditional Chinese medicine for treating chronic glomerulonephritis |
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