CN102552755B - Traditional Chinese medicine composition for treating aplastic anemia - Google Patents
Traditional Chinese medicine composition for treating aplastic anemia Download PDFInfo
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- CN102552755B CN102552755B CN2012100539588A CN201210053958A CN102552755B CN 102552755 B CN102552755 B CN 102552755B CN 2012100539588 A CN2012100539588 A CN 2012100539588A CN 201210053958 A CN201210053958 A CN 201210053958A CN 102552755 B CN102552755 B CN 102552755B
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Abstract
The invention relates to a traditional Chinese medicine composition for treating aplastic anemia. The traditional Chinese medicine composition comprises the following raw materials of herbs by weight proportion: 20-25 g of Rehmannia Glutinosa, 15-20 g of Barbary Wolfberry Fruit, 15-20 g of Malaytea Scurfpea Fruit, 15-20 g of Epimedium, 10-15 g of Colla Cornus Cervi, 3-9 g of Adix aconiti lateralis preparata, 3-9 g of Cassia Twig, 10-15 g of Radix Ginseng Rubra, 10-15 g of Dried Tangerine Peel, 10-15 g of Common Vladimiria Root, 20-25 g of Fructus Crataegi, 10-15 g of Medicated Leaven, 10-15 gof Fried Malt. The pharmaceutical ingredients in the composition are characterized in dialectic synergy. The Traditional Chinese medicine can increase the number of White blood cells, red blood cells, hemoglobin and platelet, resist infection and stop bleeding via nourishing liver and kiney, replenishing qi and blood and strengthening the spleen and stomach, and has the advantages of easy preparation process, convenience in taking, low cost, few side effects, the short period of treatment, remarkable curative effect.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine composition for the treatment of aplastic anemia.
Background technology
Aplastic anemia is a kind of marrow hematopoiesis function failure that is caused by Different types of etiopathogenises, be the intractable hematopathy of feature with hematopoietic stem cell injuries, peripheral blood pancytopenia, mainly show as hemopoietic hypofunction of marrow, pancytopenia and anemia, hemorrhage, infect.Treatment aplastic anemia doctor trained in Western medicine is with treatments such as immunosuppressant, glucocorticoid, androgen and blood transfusions at present, though the part patient can postpone separating symptom, easily repeatedly, therapeutic effect is undesirable.Used drug price height, side effect is big, takes immunosuppressant for a long time and can cause liver, renal function injury and gastral untoward reaction.
Chinese medicine thinks that aplastic anemia belongs to " asthenia " category, " deficiency syndrome should be treated by tonifying method "." the kidney being the origin of congenital constitution; main store essential substances; the essence and blood alternate, and then blood is prosperous for smart foot, and kidney main bone is again given birth to marrow; bone marrow hematogenesis ", so it is in close relations that kidney and hemopoietic have, modern pharmacology shows: Chinese medicine can promote the generation of hematopoietic stem cell, increases the immunocompetence of body, recover the immune function that hemopoietic function improves body, particularly evident when acting on peripheral blood cells decline and bone marrow depression.
Summary of the invention
The present invention is directed to the prior art deficiency, a kind of Chinese medicine composition for the treatment of aplastic anemia is provided, this medicine belongs to pure Chinese medicinal preparation, and can enrich blood yin nourishing, nourishing the liver and kidney, promoting the flow of QI in the collateral by warming the meridian, blood circulation promoting and blood stasis dispelling can effectively be treated aplastic anemia.
Technical scheme of the present invention is: a kind of Chinese medicine composition for the treatment of aplastic anemia is characterized in that being made up of following materials of weight proportions medicine: Radix Rehmanniae Preparata 20-25 gram, Fructus Lycii 15-20 gram, Fructus Psoraleae 15-20 gram, Herba Epimedii 15-20 gram, Colla cornus cervi 10-15 gram, Radix Aconiti Lateralis Preparata 3-9 gram, Ramulus Cinnamomi 3-9 gram, Radix Ginseng Rubra 10-15 gram, Pericarpium Citri Reticulatae 10-15 gram, Radix Aucklandiae 10-15 gram, Fructus Crataegi (parched to brown) 20-25 gram, Massa Medicata Fermentata 10-15 gram, Fructus Hordei Germinatus (parched) 10-15 gram.
The preferred technical solution of the present invention is: a kind of Chinese medicine composition for the treatment of aplastic anemia is characterized in that being made up of following materials of weight proportions medicine: Radix Rehmanniae Preparata 20 grams, Fructus Lycii 15 grams, Fructus Psoraleae 15 grams, Herba Epimedii 15 grams, Colla cornus cervi 10 grams, Radix Aconiti Lateralis Preparata 6 grams, Ramulus Cinnamomi 6 grams, Radix Ginseng Rubra 12 grams, Pericarpium Citri Reticulatae 15 grams, the Radix Aucklandiae 15 grams, Fructus Crataegi (parched to brown) 20 grams, Massa Medicata Fermentata 15 grams, Fructus Hordei Germinatus (parched) 15 grams.
Radix Rehmanniae Preparata in the present composition has the effect of the yin nourishing of enriching blood, life essence-filling, marrow-benefitting; Fructus Lycii has the effect of nourishing the liver and kidney, nourishing the liver to improve visual acuity, strengthening the body resistance, spermatogenesis benefit marrow, enriching yin and nourishing kidney, benefiting vital QI for tranquillizing; Fructus Psoraleae has the effect of reinforcing the kidney and supporting YANG, controlling nocturnal emission with astringent drugs reducing urination, warm spleen antidiarrheal, helping inspiration to relieve asthma; Herba Epimedii has kidney invigorating and YANG supporting, the effect of strengthening the tendons and bones, expelling wind and removing dampness; Colla cornus cervi has the lean of benefit blood, the effect of antiabortive hemostasis; Radix Aconiti Lateralis Preparata has recuperating depleted YANG and rescuing the patient from collapse, mends effect fiery supporing yang, dispersing cold for relieving pain; Ramulus Cinnamomi has the effect of diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain; Radix Ginseng Rubra has strongly invigorating primordial QI, and multiple arteries and veins takes off the effect of nourishing qi to stop admittedly; Pericarpium Citri Reticulatae has the effect of diuretic, drying dampness to eliminate phlegm in regulating qi-flowing for strengthening spleen, the accent; The Radix Aucklandiae has the effect of intestinal stasis relieving in promoting the circulation of QI to relieve pain, the accent; Fructus Crataegi (parched to brown) has the effect of spleen benefiting and stimulating the appetite, relieving dyspepsia, blood circulation promoting and blood stasis dispelling; Massa Medicata Fermentata has the effect of the stomach function regulating that helps digestion; Fructus Hordei Germinatus (parched) has promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back the effect of newborn relieving distension.
Method for making of the present invention: above-mentioned raw material of Chinese medicine is put into marmite, add clear water to exceeding raw material face 2cm, soak and began to decoct in 30 minutes; First juice: changed slow fire after intense fire is boiled 15 minutes, it is standby to pour out medicine juice, adds clear water again; Second juice: changed slow fire after intense fire is boiled 30 minutes, it is standby to pour out medicine juice, adds clear water again; The 3rd juice: changed slow fire after intense fire is boiled 30 minutes, and all poured out medicine juice standby.Three fried medicine juice are mixed, divides clothes three times, day obeys three times, every day potion, serveing on 30 days is a course for the treatment of, generally takes for 3～4 courses for the treatment of and can fully recover.
Drug component in the present composition is through dialectical compatibility, its preparation is simple, complement each other using, have synergism, reach the purpose that improves leukocyte, erythrocyte, hemoglobin, platelet and infection, hemostasis by invigorating the liver and kidney, replenishing QI and blood, strengthening the spleen and stomach etc., and expense is low, side effect is minimum, taking convenience, short treating period, evident in efficacy, the big multipotency of Patients with Aplastic Anemia is cured.Total effective rate 83.3%, cure rate 64.8%.
The specific embodiment:
Embodiment 1: a kind of Chinese medicine composition for the treatment of aplastic anemia, it is made up of following materials of weight proportions medicine: Radix Rehmanniae Preparata 20-25 gram, Fructus Lycii 15-20 gram, Fructus Psoraleae 15-20 gram, Herba Epimedii 15-20 gram, Colla cornus cervi 10-15 gram, Radix Aconiti Lateralis Preparata 3-9 gram, Ramulus Cinnamomi 3-9 gram, Radix Ginseng Rubra 10-15 gram, Pericarpium Citri Reticulatae 10-15 gram, Radix Aucklandiae 10-15 gram, Fructus Crataegi (parched to brown) 20-25 gram, Massa Medicata Fermentata 10-15 gram, Fructus Hordei Germinatus (parched) 10-15 gram.
Above-mentioned raw material of Chinese medicine is put into marmite by proportioning, add clear water to exceeding raw material face 2cm, soak and began to decoct in 30 minutes.First juice: changed slow fire after intense fire is boiled 15 minutes, it is standby to pour out medicine juice, adds clear water again; Second juice: changed slow fire after intense fire is boiled 30 minutes, it is standby to pour out medicine juice, adds clear water again; The 3rd juice: changed slow fire after intense fire is boiled 30 minutes, and all poured out medicine juice standby.Three fried medicine juice are mixed, divides clothes three times, day obeys three times, every day potion, serveing on 30 days is a course for the treatment of.
Embodiment 2: a kind of Chinese medicine composition for the treatment of aplastic anemia, it is made up of following materials of weight proportions medicine: Radix Rehmanniae Preparata 20 grams, Fructus Lycii 15 grams, Fructus Psoraleae 15 grams, Herba Epimedii 15 grams, Colla cornus cervi 10 grams, Radix Aconiti Lateralis Preparata 6 grams, Ramulus Cinnamomi 6 grams, Radix Ginseng Rubra 12 grams, Pericarpium Citri Reticulatae 15 grams, the Radix Aucklandiae 15 grams, Fructus Crataegi (parched to brown) 20 grams, Massa Medicata Fermentata 15 grams, Fructus Hordei Germinatus (parched) 15 grams.
Embodiment 3: a kind of Chinese medicine composition for the treatment of aplastic anemia, it is made up of following materials of weight proportions medicine: Radix Rehmanniae Preparata 25 grams, Fructus Lycii 20 grams, Fructus Psoraleae 20 grams, Herba Epimedii 20 grams, Colla cornus cervi 15 grams, Radix Aconiti Lateralis Preparata 3 grams, Ramulus Cinnamomi 9 grams, Radix Ginseng Rubra 10 grams, Pericarpium Citri Reticulatae 10 grams, the Radix Aucklandiae 10 grams, Fructus Crataegi (parched to brown) 25 grams, Massa Medicata Fermentata 10 grams, Fructus Hordei Germinatus (parched) 10 grams.
Embodiment 4: a kind of Chinese medicine composition for the treatment of aplastic anemia, and it is made up of following materials of weight proportions medicine:: Radix Rehmanniae Preparata 22 grams, Fructus Lycii 18 grams, Fructus Psoraleae 18 grams, Herba Epimedii 18 grams, Colla cornus cervi 12 grams, Radix Aconiti Lateralis Preparata 9 grams, Ramulus Cinnamomi 3 grams, Radix Ginseng Rubra 15 grams, Pericarpium Citri Reticulatae 12 grams, the Radix Aucklandiae 12 grams, Fructus Crataegi (parched to brown) 22 grams, Massa Medicata Fermentata 12 grams, Fructus Hordei Germinatus (parched) 12 grams.
Clinical efficacy is summed up:
One, general data: this Chinese medicine composition is used for many years clinically, clinical observation case 106 examples, male 58 examples, women 48 examples, 20～30 years old age, 46 examples, 30～45 years old age, 60 examples.
Two, diagnostic criteria
1, tcm diagnosis standard: aplastic anemia belongs to categories such as " asthenia ", " blood disorder " of Chinese medicine, and disease sees that color is white, dizziness headache, order is stuck with paste tinnitus, and heart beating is breathed hard, spiritlessness and weakness, soreness of waist and knee joint, the difficult dreaminess of sleeping, forgetful, dysphoria with feverish sensation in the chest palms and soles, yellow urine, the slight edema of lower limb, extremity skin has petechia, pale tongue, tongue are greasy in vain, the clinical manifestation of the unable grade of stringy,thready and rapid pulse.
2, Western medicine diagnose standard: pancytopenia, reticulocyte percent＜0.01, percentage of lymphocyte increases; Generally see liver, splenomegaly; Bone marrow multi-section position hypoplasia (＜normal 50%) or severe lower (＜normal 25%), and hematopoietic cell reduces, and the non-hematopoietic cell ratio increases, bone marrow granule inanition (person of having ready conditions makes the visible hemopoietic tissue of bone marrow biopsy and evenly reduces); Cause the refractory anemia in the other diseases of pancytopenia such as paroxysmal nocturnal hemoglobinuria, the myelodysplastic syndrome, acute hemopoietic function stagnation, myelofibrosis, acute leukemia, malignant histocytosis etc. except the energy; General anti-anemic drug thing is failed to respond to any medical treatment.
Three, usage and dosage: during clinical practice, the component in the present composition, consumption are taken the circumstances into consideration increase and decrease according to patient's body weight, age and symptom.Potion on the one after three times extracting juice of decocting mix, divides and takes for early, middle and late three times.30 days is a course for the treatment of.
Four, curative effect determinate standard
Recovery from illness: the clinical symptoms complete obiteration for the treatment of back, check that through bone marrow aspiration all are normal, all are normal through observing 3～5 months.
Produce effects: treatment back cardinal symptom disappears substantially, observes continuously 3～5 months, and no longer recurrence is normal substantially through the bone marrow aspiration inspection.
Effectively: symptom makes moderate progress after treating, and observes no longer recurrence in 3～5 months continuously, and is normal substantially through the bone marrow aspiration inspection.
Invalid: symptom does not have improvement or improvement is arranged after treating, and observes through 3～5 months, and symptom is the same, checks no change through bone marrow aspiration.
Five, therapeutic effect: use the Chinese medicine composition for the treatment of aplastic anemia of the present invention, wherein cure 70 examples, produce effects 14 examples, effective 6 examples, invalid 18 examples, cure rate 64.8%, obvious effective rate 12.9%, effective percentage 5.6%, total effective rate are 83.3%.
Six, model case
1, Xu certain, man, 32 years old, because feeling badly, do the bone marrow aspiration inspection in March, 2002, be diagnosed as aplastic anemia, short-term is accepted prednisone, the leucogen, treatments such as methyl testosterone, hematochrome 4 restrains %, platelet 50,000/mm3 on inspection, leukocyte 2.000/mm3, the clinical manifestation disease is seen green around the gills, dizziness headache, order is stuck with paste tinnitus, and heart beating is breathed hard, spiritlessness and weakness, soreness of waist and knee joint, the difficult dreaminess of sleeping, forgetful, extremity skin has petechia, and the pale tongue tongue is greasy in vain, and stringy,thready and rapid pulse is unable, take the present composition and take effect after 30 doses one course for the treatment of, stop the blood transfusion, after take medicine continuously again 3 courses for the treatment of, all diseases disappear, the color chemical examination is normal, hale and hearty, can operate as normal and life.
2, Song, the woman, 26 years old, in May, 2003 was because of general weakness, shortness of breath and palpitation, indigestion and loss of appetite, lusterless complexion, dryness of the tongue, white and thin fur, the petechia appears in whole body.Medical check: hemoglobin 4 gram %, leukocyte 2.500/mm3, erythrocyte 1,500,000/mm3, platelet 30,000/mm3, the bone marrow aspiration inspection is diagnosed as aplastic anemia, the state of an illness is clearly better rehabilitation after continuous 3 courses for the treatment of of taking medicine after beginning to take 20 doses of medicines of the present invention in June, 2003.
3, Lee, man, 40 years old, in August, 2004 because of heart beating, breathe hard, dizzy, inappetence, lassitude, pale complexion, symptoms such as lip is light red are gone to hospital therapy, through the bone marrow aspiration inspection, are diagnosed as aplastic anemia, medical check: erythrocyte 2,600,000/mm3, leukocyte 4.000/mm3, haemachrome 50%, platelet 5.5 ten thousand/mm3, need enrich blood in every month 2 times, take a favorable turn by the state of an illness after taking 30 doses of medicines of the present invention, rehabilitation after continuous 4 courses for the treatment of of taking medicine.
Claims (2)
1. Chinese medicine composition for the treatment of aplastic anemia, it is made up of following materials of weight proportions medicine: Radix Rehmanniae Preparata 20-25 gram, Fructus Lycii 15-20 gram, Fructus Psoraleae 15-20 gram, Herba Epimedii 15-20 gram, Colla cornus cervi 10-15 gram, Radix Aconiti Lateralis Preparata 3-9 gram, Ramulus Cinnamomi 3-9 gram, Radix Ginseng Rubra 10-15 gram, Pericarpium Citri Reticulatae 10-15 gram, Radix Aucklandiae 10-15 gram, Fructus Crataegi (parched to brown) 20-25 gram, Massa Medicata Fermentata 10-15 gram, Fructus Hordei Germinatus (parched) 10-15 gram.
2. a kind of Chinese medicine composition for the treatment of aplastic anemia according to claim 1, it is made up of following materials of weight proportions medicine: Radix Rehmanniae Preparata 20 grams, Fructus Lycii 15 grams, Fructus Psoraleae 15 grams, Herba Epimedii 15 grams, Colla cornus cervi 10 grams, Radix Aconiti Lateralis Preparata 6 grams, Ramulus Cinnamomi 6 grams, Radix Ginseng Rubra 12 grams, Pericarpium Citri Reticulatae 15 grams, the Radix Aucklandiae 15 grams, Fructus Crataegi (parched to brown) 20 grams, Massa Medicata Fermentata 15 grams, Fructus Hordei Germinatus (parched) 15 grams.
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| CN103656464B (en) * | 2013-12-24 | 2015-09-09 | 李明莉 | A kind of Chinese medicine for the treatment of aplastic anemia |
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