CN103751607A - Traditional Chinese medicine composition for the treatment of aplastic anemia - Google Patents
Traditional Chinese medicine composition for the treatment of aplastic anemia Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for the treatment of aplastic anemia. The traditional Chinese medicine composition consists of traditional Chinese medicine raw materials by weight part: 10-40 parts of radix rehmanniae, 10-30 parts of prepared rhizome rehmannia, 5-25 parts of dogwood, 10-30 parts of mulberry fruit, 5-25 parts of fruit of Chinese wolfberry, 10-30 parts of salvia miltiorrhiza, 5-25 parts of angelica, 10-30 parts of astragalus membranaceus, 5-25 parts of radix paeoniae alba, 10-40 parts of glossy privet fruit, 5-25 parts of codonopsis pilosula, 10-30 parts of rhizoma alismatis, 5-25 parts of eclipta alba, 5-20 parts of golden cypress, 5-25 parts of herba agrimoniae, 10-30 parts of radix scutellariae, 5-25 parts of fleece-flower root, 5-25 parts of couch grass root, 5-20 parts of caulis dendrobii, 5-25 parts of sanguisorba, 5-25 parts of white atractylodes rhizome and 5-15 parts of liquorice. The traditional Chinese medicine composition provided by the invention has the efficacies of nourishing the liver and kidney, invigorating spleen and supplementing qi, replenishing blood and nourishing yin, promoting blood circulation to remove blood stasis, and nourishing the bone marrow, and is distinct in curative effect and reliable in effect of the treatment of aplastic anemia.
Description
Technical field
The present invention relates to a kind of pharmaceutical product of not determining structure of traditional herbal medicines, especially a kind of Chinese medicine composition for the treatment of aplastic anemia.
Background technology
Aplastic anemia is called for short aplastic anemia, that a kind of hemopoietic function of bone marrow being caused by factors such as biology, chemistry, physics goes down or exhaustion, intractable hematopathy take hematopoietic stem cell injuries, peripheral blood pancytopenia as feature is the more common disease of hemopoietic system.Its main manifestations is hemopoietic hypofunction of marrow, pancytopenia and anemia, hemorrhage, infection.Although each age group all can be fallen ill, common with person between twenty and fifty, and male is more than women, northern more than south.Treatment aplastic anemia doctor trained in Western medicine is with treatments such as immunosuppressant, glucocorticoid, androgen and blood transfusions at present, although some patients were relief of symptoms temporarily, easily repeatedly, therapeutic effect is undesirable.And drug price used is high, side effect is large, and long-term taking immunosuppressant can cause liver, renal function injury and gastral untoward reaction.
The traditional Chinese medical science is by aplastic anemia ownership " asthenia ", " blood disorder " category.Think overstrain internal injury, experience pathogen, or poisonous substance kiling the impairment of QI-blood, is the Etiological that causes primary disease.The blood of can not uniting as insufficiency of the spleen, having a guilty conscience can not main blood, and deficiency of the liver can not store blood, the essence and blood loss of suffering from a deficiency of the kidney, the interior internal organs that can not be in harmonious proportion, can not escort battalion outward and defend, and defend outer not Yin Zeyi and suffer from diseases caused by exogenous pathogenic factor for heat.Among the five internal organs, especially dirty important with spleen kidney two, if insufficiency of the spleen and kidney, because void causes damage, because damaging into labor, essence and blood does not fill and is asthenia.
According to theory of Chinese medical science, for the pathogeny of aplastic anemia, adopt the method for the treatment of of nourishing the liver and kidney, invigorating the spleen and benefiting QI, the yin nourishing of enriching blood, blood circulation promoting and blood stasis dispelling, life essence-filling, marrow-benefitting, carry out dialectical prescription compatibility, to reach the object for the treatment of both the principal and secondary aspects of a disease.
Summary of the invention
In order to overcome, in prior art, treat the deficiency that aplastic anemia exists, the invention provides a kind of prepare easy, cost is low, the Chinese medicine composition of evident in efficacy, the treatment aplastic anemia that has no side effect.
The technical solution adopted for the present invention to solve the technical problems is: a kind of Chinese medicine composition for the treatment of aplastic anemia, it is characterized in that: its raw material of Chinese medicine and weight portion proportioning are: Radix Rehmanniae 10-40 part, Radix Rehmanniae Preparata 10-30 part, Fructus Corni 5-25 part, Fructus Mori 10-30 part, Fructus Lycii 5-25 part, Radix Salviae Miltiorrhizae 10-30 part, Radix Angelicae Sinensis 5-25 part, Radix Astragali 10-30 part, Radix Paeoniae Alba 5-25 part, Fructus Ligustri Lucidi 10-40 part, Radix Codonopsis 5-25 part, Rhizoma Alismatis 10-30 part, Herba Ecliptae 5-25 part, Cortex Phellodendri 5-20 part, Herba Agrimoniae 5-25 part, Radix Scutellariae 10-30 part, Radix Polygoni Multiflori 5-25 part, Rhizoma Imperatae 5-25 part, Herba Dendrobii 5-20 part, Radix Sanguisorbae 5-25 part, Rhizoma Atractylodis Macrocephalae 5-25 part, Radix Glycyrrhizae 5-15 part.
The preferred technical solution of the present invention is: a kind of Chinese medicine composition for the treatment of aplastic anemia, is characterized in that: its raw material of Chinese medicine and weight portion proportioning are: 25 parts, the Radix Rehmanniae, 20 parts, Radix Rehmanniae Preparata, 15 parts of Fructus Corni, 20 parts of Fructus Mori, 15 parts of Fructus Lycii, 20 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Astragali, 15 parts of the Radix Paeoniae Albas, 25 parts of Fructus Ligustri Lucidi, 15 parts of Radix Codonopsis, 20 parts of Rhizoma Alismatis, 15 parts of Herba Ecliptaes, 12 parts of Cortex Phellodendris, 15 parts of Herba Agrimoniaes, 20 parts of Radix Scutellariaes, 15 parts of Radix Polygoni Multiflori, 15 parts of Rhizoma Imperataes, 10 parts of Herba Dendrobiis, 15 parts of Radix Sanguisorbaes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts, Radix Glycyrrhizae.
Chinese medicine composition of the present invention is under Traditional Chinese medical theory and clinical experience guidance, selected medicament composing prescription.In Chinese medicine composition of the present invention: the Radix Rehmanniae has the effect of clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, pain relieving regulating menstruation; Radix Rehmanniae Preparata has the effect of the yin nourishing of enriching blood, life essence-filling, marrow-benefitting; Fructus Corni has the effect of liver and kidney tonifying, essence astringing and desertion stemming; Fructus Mori has nourishing YIN and supplementing blood, the effect of the intestine moistening of promoting the production of body fluid; Fructus Lycii has the effect of nourishing the liver and kidney, nourishing the liver to improve visual acuity, strengthening the body resistance, spermatogenesis benefit marrow, enriching yin and nourishing kidney, benefiting vital QI for tranquillizing; Radix Salviae Miltiorrhizae has the effect of promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind; Radix Angelicae Sinensis have enrich blood invigorate blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation; The Radix Astragali has that benefiting QI for strengthening the superficies, tonifying the lung spleen invigorating, arresting sweating are admittedly de-, wind dispelling is transported malicious effect; The Radix Paeoniae Alba has the effect of clear and coherent blood vessels, nourishing blood to suppress the hyperactive liver, slow middle arresting sweating; Fructus Ligustri Lucidi has the effect that nourishing the liver and kidney, tonifying YIN nourish blood; Radix Codonopsis has the effect of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; Rhizoma Alismatis has promoting diuresis to eliminate damp pathogen, treating stranguria effect expels the heat-evil; Herba Ecliptae has the effect of liver-nourishing kidney-boosting, cooling blood for hemostasis; Cortex Phellodendri has heat clearing and damp drying, pathogenic fire purging except steaming, the effect of detoxification sore treatment; Herba Agrimoniae has the effect of astringing to arrest bleeding, detoxification sore treatment, parasite killing, puckery antiperspirant, cough-relieving; Radix Scutellariae has the effect of heat clearing and damp drying, eliminating fire and detoxication, arresting bleeding and miscarriage prevention; Radix Polygoni Multiflori has the effect of the liver benefiting that nourishes blood, controlling nocturnal emission with astringent drugs kidney tonifying; Rhizoma Imperatae has the effect of cooling blood for hemostasis, heat-clearing and toxic substances removing; Herba Dendrobii has the effect of reinforcing stomach reg fluid, nourishing YIN and clearing away heat; Radix Sanguisorbae has the effect of cooling blood for hemostasis, heat-clearing and toxic substances removing, pathogenic fire purging sore; The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, the antiabortive effect of hidroschesis; Radix Glycyrrhizae has the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, coordinating the actions of various ingredients in a prescription.The selected medicament composing prescription of the present invention, its drug component is through dialectical compatibility, helps using mutual assistant, plays altogether nourishing the liver and kidney, invigorating the spleen and benefiting QI, the effect of the yin nourishing of enriching blood, blood circulation promoting and blood stasis dispelling, life essence-filling, marrow-benefitting, and the treatment of aplastic anemia is reached to treating both the principal and secondary aspects of a disease.
The component of the present composition all adopts natural raw material of Chinese medicine, and its preparation is easy, medicine source is wide, cost is low.The present invention follows the prescriptions principle of the traditional Chinese medical science, and various component drug adopt the use that is decocted in water for oral dose.Through clinical practice checking, it is evident in efficacy reliable, and the property of medicine is gentle, does not occur toxic and side effects, and effective percentage reaches 93%, cure rate 68%.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1
Treat a Chinese medicine composition for aplastic anemia, its raw material of Chinese medicine and weight proportion are: Radix Rehmanniae 25g, Radix Rehmanniae Preparata 20g, Fructus Corni 15g, Fructus Mori 20g, Fructus Lycii 15g, Radix Salviae Miltiorrhizae 20g, Radix Angelicae Sinensis 15g, Radix Astragali 20g, Radix Paeoniae Alba 15g, Fructus Ligustri Lucidi 25g, Radix Codonopsis 15g, Rhizoma Alismatis 20g, Herba Ecliptae 15g, Cortex Phellodendri 12g, Herba Agrimoniae 15g, Radix Scutellariae 20g, Radix Polygoni Multiflori 15g, Rhizoma Imperatae 15g, Herba Dendrobii 10g, Radix Sanguisorbae 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Glycyrrhizae 10g.
Embodiment 2
Treat a Chinese medicine composition for aplastic anemia, its raw material of Chinese medicine and weight proportion are: Radix Rehmanniae 15g, Radix Rehmanniae Preparata 30g, Fructus Corni 5g, Fructus Mori 25g, Fructus Lycii 10g, Radix Salviae Miltiorrhizae 30g, Radix Angelicae Sinensis 5g, Radix Astragali 25g, Radix Paeoniae Alba 10g, Fructus Ligustri Lucidi 40g, Radix Codonopsis 5g, Rhizoma Alismatis 30g, Herba Ecliptae 10g, Cortex Phellodendri 20g, Herba Agrimoniae 5g, Radix Scutellariae 30g, Radix Polygoni Multiflori 10g, Rhizoma Imperatae 25g, Herba Dendrobii 5g, Radix Sanguisorbae 25g, Rhizoma Atractylodis Macrocephalae 10g, Radix Glycyrrhizae 12g.
Embodiment 3
Treat a Chinese medicine composition for aplastic anemia, its raw material of Chinese medicine and weight proportion are: Radix Rehmanniae 20g, Radix Rehmanniae Preparata 15g, Fructus Corni 20g, Fructus Mori 10g, Fructus Lycii 20g, Radix Salviae Miltiorrhizae 15g, Radix Angelicae Sinensis 5g, Radix Astragali 10g, Radix Paeoniae Alba 20g, Fructus Ligustri Lucidi 15g, Radix Codonopsis 20g, Rhizoma Alismatis 10g, Herba Ecliptae 5g, Cortex Phellodendri 15g, Herba Agrimoniae 10g, Radix Scutellariae 25g, Radix Polygoni Multiflori 5g, Rhizoma Imperatae 20g, Herba Dendrobii 12g, Radix Sanguisorbae 5g, Rhizoma Atractylodis Macrocephalae 20g, Radix Glycyrrhizae 5g.
Embodiment 4
Treat a Chinese medicine composition for aplastic anemia, its raw material of Chinese medicine and weight proportion are: Radix Rehmanniae 10g, Radix Rehmanniae Preparata 25g, Fructus Corni 10g, Fructus Mori 30g, Fructus Lycii 5g, Radix Salviae Miltiorrhizae 25g, Radix Angelicae Sinensis 10g, Radix Astragali 30g, Radix Paeoniae Alba 5g, Fructus Ligustri Lucidi 20g, Radix Codonopsis 10g, Rhizoma Alismatis 25g, Herba Ecliptae 10g, Cortex Phellodendri 5g, Herba Agrimoniae 25g, Radix Scutellariae 15g, Radix Polygoni Multiflori 20g, Rhizoma Imperatae 10g, Herba Dendrobii 15g, Radix Sanguisorbae 20g, Rhizoma Atractylodis Macrocephalae 5g, Radix Glycyrrhizae 6g.
Embodiment 5
Treat a Chinese medicine composition for aplastic anemia, its raw material of Chinese medicine and weight proportion are: Radix Rehmanniae 40g, Radix Rehmanniae Preparata 10g, Fructus Corni 25g, Fructus Mori 15g, Fructus Lycii 25g, Radix Salviae Miltiorrhizae 10g, Radix Angelicae Sinensis 25g, Radix Astragali 15g, Radix Paeoniae Alba 25g, Fructus Ligustri Lucidi 10g, Radix Codonopsis 25g, Rhizoma Alismatis 15g, Herba Ecliptae 25g, Cortex Phellodendri 10g, Herba Agrimoniae 20g, Radix Scutellariae 10g, Radix Polygoni Multiflori 25g, Rhizoma Imperatae 5g, Herba Dendrobii 20g, Radix Sanguisorbae 10g, Rhizoma Atractylodis Macrocephalae 25g, Radix Glycyrrhizae 15g.
Chinese medicine composition in embodiment of the present invention decocting method is routinely produced medicament.Concrete grammar is as follows: the raw material of Chinese medicine of prescription is put into container, adds cold water and cover powder, soak 15～20 minutes, then add water and do not have approximately 6 centimetres of powder, decoct for the first time, adopt intense fire to decoct before at a simmer, after boiling with slow fire boiling 20～30 minutes; Decoct for the second time, add water and do not have approximately 4 centimetres of powder, after water boils, decoct 15～20 minutes.Decoct extracting juice twice, merge.
The present invention, with the given a kind of Chinese medicine composition for the treatment of aplastic anemia of embodiment 1, does clinical efficacy and is summarized as follows:
One, general data: this Chinese medicine composition is applied to clinical observation case 100 examples, male 58 examples, female's 42 examples, 20～60 years old age.
Two, diagnostic criteria:
1, tcm diagnosis standard: aplastic anemia belongs to the categories such as " asthenia ", " blood disorder " of Chinese medicine, and disease is seen pale complexion, dizziness headache, order is stuck with paste tinnitus, and heart beating is breathed hard, spiritlessness and weakness, soreness of waist and knee joint, the difficult dreaminess of sleeping, forgetful, dysphoria with feverish sensation in the chest palms and soles, yellow urine, edema that lower limb are slight, extremity skin has petechia, pale tongue, tongue is greasy in vain, the clinical manifestation of the unable grade of stringy,thready and rapid pulse.
2, Western medicine diagnose standard: pancytopenia, reticulocyte percent < 0.01, percentage of lymphocyte increases;
Generally see liver, splenomegaly; Bone marrow multiple location hypoplasia (< normal 50%) or severe lower (< normal 25%), hematopoietic cell reduces, non-hematopoietic cell ratio increases, bone marrow granule inanition (person of having ready conditions makes the visible hemopoietic tissue of bone marrow biopsy and evenly reduces); Except energy, cause that the other diseases of pancytopenia is as the refractory anemia in paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome, acute aplastic crisis, myelofibrosis, acute leukemia, malignant histocytosis etc.; General anti-anemic drug thing is failed to respond to any medical treatment.
Three, usage and dosage: during clinical practice, potion on the one, the about 400ml of twice extracting juice of decocting, point morning, late twice empty stomach decoction being taken warmly.It within 15 days, is a course for the treatment of.Avoid cold and uncooked food during the treatment thing of pungent stimulation.
Four, criterion of therapeutical effect:
(1) recovery from illness: after treatment, clinical symptoms disappears completely, checks that through bone marrow aspiration all are normal, through observing 3～5 months, all are normal;
(2) effective: after treatment, cardinal symptom disappears substantially, Continuous Observation 3～5 months, no longer recurrence, through bone examination by centesis normal;
(3) effective: after treatment, symptom makes moderate progress, Continuous Observation no longer recurrence in 3～5 months, checks normal through bone marrow aspiration;
(4) invalid: after treatment, symptom, without improving or being improved, was observed through 3～5 months, and symptom is the same, through bone marrow aspiration, checks unchanged.
Five, therapeutic effect: in this clinical observation case, take medicine 2-6 the course for the treatment of, recovery from illness 68 examples, follow up a case by regular visits to and have no recurrence; Effective 16 examples, effective 9 examples, invalid 7 examples.During treatment, there is not toxic and side effects.
Six, model case:
Case 1:
Normal certain, female, 26 years old.Because of pale complexion, dizziness headache, order is stuck with paste tinnitus, and heart beating is breathed hard, spiritlessness and weakness, soreness of waist and knee joint, the difficult dreaminess of sleeping, forgetful, extremity skin has petechia, the symptoms such as pale tongue tongue is greasy in vain, and stringy,thready and rapid pulse is unable are gone to hospital therapy, do bone marrow aspiration inspection, are diagnosed as aplastic anemia.Once took the treatments such as methyl testosterone, poor effect.Take 2 courses for the treatment of of medicament prepared by Chinese medicine composition of the present invention, the state of an illness is alleviated; Continue to take 2 courses for the treatment of, all diseases disappear, and color chemical examination is normal, hale and hearty, can normally work and live, and cure.
Case 2:
Cui, man, 32 years old.Because of heart beating, breathe hard, dizzy, inappetence, lassitude, pale complexion, edema that lower limb are slight, lip is light red etc., and symptom is gone to hospital therapy, through bone marrow aspiration inspection, is diagnosed as aplastic anemia.Laboratory examination: erythrocyte 2,600,000/mm3, leukocyte 4.000/mm3, haemachrome 50%, platelet 5.5 ten thousand/mm3.Take 2 courses for the treatment of of medicament prepared by Chinese medicine composition of the present invention, the state of an illness takes a favorable turn; Continue to take 3 courses for the treatment of, all diseases disappear, and color chemical examination is normal, cure.
Case 3:
Poplar, man, 32 years old.Be diagnosed as aplastic anemia 1 year, general weakness, shortness of breath and palpitation, indigestion and loss of appetite, lusterless complexion, dryness of the tongue, white and thin fur, there is petechia in whole body.The Drug therapys such as oral stanozolol, ampeptide elemente, hematochrome is always unstable, time low when high, be interrupted and take Chinese herbal medicine and blood transfusion Supporting Therapy, effect is undesirable.Take 3 courses for the treatment of of medicament prepared by Chinese medicine composition of the present invention, the state of an illness is clearly better; Continue to take 3 courses for the treatment of, all diseases disappear, and blood routine examination is normal, cure.Follow up a case by regular visits to half a year without recurrence.
Claims (2)
1. treat the Chinese medicine composition of aplastic anemia for one kind, it is characterized in that: its raw material of Chinese medicine and weight portion proportioning are: Radix Rehmanniae 10-40 part, Radix Rehmanniae Preparata 10-30 part, Fructus Corni 5-25 part, Fructus Mori 10-30 part, Fructus Lycii 5-25 part, Radix Salviae Miltiorrhizae 10-30 part, Radix Angelicae Sinensis 5-25 part, Radix Astragali 10-30 part, Radix Paeoniae Alba 5-25 part, Fructus Ligustri Lucidi 10-40 part, Radix Codonopsis 5-25 part, Rhizoma Alismatis 10-30 part, Herba Ecliptae 5-25 part, Cortex Phellodendri 5-20 part, Herba Agrimoniae 5-25 part, Radix Scutellariae 10-30 part, Radix Polygoni Multiflori 5-25 part, Rhizoma Imperatae 5-25 part, Herba Dendrobii 5-20 part, Radix Sanguisorbae 5-25 part, Rhizoma Atractylodis Macrocephalae 5-25 part, Radix Glycyrrhizae 5-15 part.
2. a kind of Chinese medicine composition for the treatment of aplastic anemia according to claim 1, is characterized in that: its raw material of Chinese medicine and weight portion proportioning are: 10 parts, 25 parts, the Radix Rehmanniae, 20 parts, Radix Rehmanniae Preparata, 15 parts of Fructus Corni, 20 parts of Fructus Mori, 15 parts of Fructus Lycii, 20 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Angelicae Sinensis, 20 parts of the Radixs Astragali, 15 parts of the Radix Paeoniae Albas, 25 parts of Fructus Ligustri Lucidi, 15 parts of Radix Codonopsis, 20 parts of Rhizoma Alismatis, 15 parts of Herba Ecliptaes, 12 parts of Cortex Phellodendris, 15 parts of Herba Agrimoniaes, 20 parts of Radix Scutellariaes, 15 parts of Radix Polygoni Multiflori, 15 parts of Rhizoma Imperataes, 10 parts of Herba Dendrobiis, 15 parts of Radix Sanguisorbaes, the Rhizoma Atractylodis Macrocephalae 15, Radix Glycyrrhizae.
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