CN1840006A - Medicine for treating aplastic anemia - Google Patents

Abstract

The invention discloses a medicament for treating regenerative anemia, which is preparing from pilose asiabell root, white atractylodes rhizome, astragalus root, Chinese angelica root, prepared rhizome of rehmannia, licorice root, prepared aconite root, hairy vein agrimony, spatholobus stem, notoginseng, banksia rose, deer horn gum, donkey-hide gelatin, tortoise-plastron glue, root bark of tree peony and dried rehmannia root.

Description

The medicine of treatment aplastic anemia

Technical field: the present invention relates to a kind of medicine for the treatment of aplastic anemia, belong to the field of Chinese medicines.

Background technology: aplastic anemia belongs to categories such as " asthenia ", " blood disorder " of motherland's medical science.Just prosperous from the beginning of the heresy Sheng, evil quadrature is striven, and belongs to excess syndrome.Earlier involve cloudy the damage, i.e. hypofunction and anemia gradually transfers deficiency syndrome to because of yang deficiency.The existing tens of thousands of people of patient of aplastic anemia suffers from China at present, and wherein 50% is the minor, has a strong impact on people's work study, and good medicine improves patient's health status to press for a kind of therapeutic effect.

Summary of the invention: in order to solve the problem of above-mentioned existence, the invention provides a kind of benefiting qi and nourishing blood that has, short treating period and therapeutic effect are obvious, the medicine of the treatment aplastic anemia that cost is low.

The objective of the invention is to be achieved through the following technical solutions: the medicine of treatment aplastic anemia, it is made up of the component of following parts by weight proportioning:

Radix Codonopsis 30～45, Rhizoma Atractylodis Macrocephalae (parched) 15～30, Radix Astragali Mongolici (processed) 60～80, Radix Angelicae Sinensis 15～30, Radix Rehmanniae Preparata 30～50, Radix Glycyrrhizae Preparata 6～15, Radix Aconiti Lateralis Preparata 20～35, Herba Agrimoniae 30～45, Caulis Spatholobi 30～50, Radix Notoginseng 5～15, Radix Aucklandiae (Radix Vladimiriae) 6～15, Colla cornus cervi 15～30, Colla Corii Asini 15～30, Colla Plastri Testudinis 15～30, Cortex Moutan 10～20, the Radix Rehmanniae 30～35.

Medicament selection Radix Codonopsis of the present invention, Rhizoma Atractylodis Macrocephalae (parched), Radix Astragali Mongolici (processed), Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata, Radix Aconiti Lateralis Preparata, Herba Agrimoniae, Caulis Spatholobi, Radix Notoginseng, Radix Aucklandiae (Radix Vladimiriae), Colla cornus cervi, Colla Corii Asini, Colla Plastri Testudinis, Cortex Moutan, the Radix Rehmanniae are formed, medicine wherein of the present invention is reused Radix Aconiti Lateralis Preparata, Cornu Cervi in forming, borrow the big heat of Radix Aconiti Lateralis Preparata Da Xin, big kidney-Yang invigorating.Radix Aconiti Lateralis Preparata has excited systemic cell vitality and boosting, the strong positive secret marrow of Cornu Cervi, can promote the complete blood cell growth, similar functions of hormones be arranged, Radix Astragali invigorating the spleen and replenishing QI, the blood coagulation of Herba Agrimoniae repercussive, the Radix Aucklandiae (Radix Vladimiriae) sending down the abnormal ascending QI, Colla Corii Asini, Colla Plastri Testudinis nourishing YIN, life essence-filling, marrow-benefitting, make each efficacy of drugs produce synergism these drug regimens, can effectively treat aplastic anemia.

Pharmacological action:

Radix Codonopsis:

1, nature and flavor: sweet flat;

2, return through the meridian of Foot-TAI YIN of starting with;

3, function cures mainly: invigorating the spleen and replenishing QI, promote the production of body fluid, the function of spleen and stomach regulating weakness, QI and blood deficiency.

Rhizoma Atractylodis Macrocephalae (parched):

1, nature and flavor: bitter sweet, warm;

2, return through: go into spleen, stomach warp;

3, function cures mainly: spleen reinforcing, stomach reinforcing, dampness and in.

Radix Astragali Mongolici (processed):

1, nature and flavor: sweet, tepor;

2, return through: go into lung, spleen channel;

3, function cures mainly: benefit is defended consolidating superficial resistance, inducing diuresis to remove edema, and poison holding, granulation promoting can be treated the card of all weakness of QI blood deficiency.

Radix Angelicae Sinensis:

1, nature and flavor: Gan Xin, temperature;

2, return through: go into the heart, liver, spleen channel;

3, function cures mainly: benefiting blood and regulating blood circulation, menstruction regulating and pain relieving is moisturized laxation.

Radix Rehmanniae Preparata:

1, nature and flavor: sweet, tepor;

2, return through: go into liver, kidney channel;

3, function cures mainly: YIN nourishing, enrich blood, and control deficiency of YIN insufficiency of blood, it is empty not enough to enrich blood greatly, promoting blood circulation, physical strength profiting.

Radix Glycyrrhizae Preparata:

1, nature and flavor: sweet, flat;

2, return through: go into spleen, stomach, lung meridian;

3, function cures mainly: and middle emergency, lung moistening, detoxifcation, coordinating the actions of various ingredients in a prescription, the pathogen of main vital organs of the human body cold and heat.

Radix Aconiti Lateralis Preparata:

1, nature and flavor: Xin Gan, heat, poisonous;

2, return through: go into the heart, spleen, kidney channel;

3, function cures mainly: recuperating depleted YANG is mended fire, dispelling cold and removing dampness.

Herba Agrimoniae:

1, nature and flavor: toil, flat;

2, return through: go into lung, liver, spleen channel;

3, function cures mainly: hemostasis, be good for the stomach.

Caulis Spatholobi:

1, nature and flavor: bitter sweet, temperature;

2, return through: go into the heart, spleen two warps;

3, function cures mainly: have and invigorate blood circulation, enrich blood, effects such as Shujin.

Radix Notoginseng:

1, nature and flavor: sweet little hardship, temperature;

2, return through: go into liver, stomach, large intestine channel;

3, function cures mainly: hemostasis, dissipating blood stasis, detumescence, analgesic therapy.

Radix Aucklandiae (Radix Vladimiriae):

1, nature and flavor: arduous, temperature;

2, return through: go into lung, liver, spleen channel;

3, function cures mainly: promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach.

Colla cornus cervi:

1, nature and flavor: sweet, flat;

2, return through: go into liver, kidney channel;

3, function cures mainly: have the effect that QI invigorating is enriched blood.

Colla Corii Asini:

1, nature and flavor: sweet, flat;

2, return through: go into lung, liver, kidney channel;

3, function cures mainly: nourishing YIN and supplementing blood, and antiabortive.

Colla Plastri Testudinis:

1, nature and flavor: sweet salty, flat;

2, return through: go into liver, kidney channel;

3, function cures mainly: YIN nourishing, enrich blood, stop blooding.

Cortex Moutan:

1, nature and flavor: arduous, cold;

2, return through: go into the heart, liver, kidney channel;

3, function cures mainly: heat clearing away, removing heat from blood, and blood, clear stasis of blood effect.

The specific embodiment:

The test example:

The clinical observation of Drug therapy aplastic anemia of the present invention:

1, physical data

From 2001 to 2005, accept the patient of 350 aplastic anemia altogether for medical treatment, wherein the male patient is 185,165 of female patients, below 10 years old 30,10～20 years old 125,20～40 years old 115, more than 40 years old 80.

2, diagnostic criteria

(1) tcm diagnosis standard: aplastic anemia belongs to categories such as " asthenia ", " blood disorder " of Chinese medicine, and disease is seen pale complexion, dizziness headache, order is stuck with paste tinnitus, and heart beating is breathed hard, spiritlessness and weakness, soreness of waist and knee joint, the difficult dreaminess of sleeping, forgetful, dysphoria with feverish sensation in the chest palms and soles, yellow urine, the slight edema of lower limb, extremity skin has petechia, pale tongue, tongue are greasy in vain, the clinical manifestation of the unable grade of stringy,thready and rapid pulse.

(2) Western medicine diagnose standard: 1. pancytopenia, reticulocyte percent＜0.01, percentage of lymphocyte increases; 2. generally see liver, splenomegaly; 3. bone marrow multi-section position hypoplasia (＜normal 50%) or severe lower (＜normal 25%), and hematopoietic cell reduces, and the non-hematopoietic cell ratio increases, bone marrow granule inanition (person of having ready conditions makes the visible hemopoietic tissue of bone marrow biopsy and evenly reduces); 4. can except cause the refractory anemia in the other diseases of pancytopenia such as paroxysmal nocturnal hemoglobinuria, the myelodysplastic syndrome, acute hemopoietic function stagnation, myelofibrosis, acute leukemia, malignant histocytosis etc.; 5. general anti-anemic drug thing is failed to respond to any medical treatment.

3, using method

Every day, potion was decocted in water for oral dose, and divided and took for three times, and 30 days is a course of treatment, generally takes for 3～4 courses of treatment and can fully recover.

4, curative effect determinate standard

Recovery from illness: the clinical symptoms complete obiteration of treatment back, check that through bone marrow aspiration all are normal, all are normal through observing 3～5 months.

Produce effects: treatment back cardinal symptom disappears substantially, observes continuously 3～5 months, and no longer recurrence is normal substantially through the bone marrow aspiration inspection.

Effectively: symptom makes moderate progress after treating, and observes no longer recurrence in 3～5 months continuously, and is normal substantially through the bone marrow aspiration inspection.

Invalid: symptom does not have improvement or improvement is arranged after treating, and observes through 3～5 months, and symptom is the same, checks no change through bone marrow aspiration.

5, therapeutic effect (see Table 1, table 2)

Table 1: case and therapeutic effect relationship:

Table 2: case and the course of treatment relation:

			Healing time
								Case	Recovery from illness	30 days	60 days	90 days	120 days
2001	77	69	2	15	37	15
							2002	68	61	1	12	35	13
2003	59	53	2	13	30	8
							2004	80	72	3	18	43	8
2005	66	59	1	19	30	9

6, the case case is lifted:

Case one: Liu Yuhua, woman, 35 years old, the workman, the patient does bone marrow aspiration inspection because of feeling badly in Chinese medical university April calendar year 2001, is diagnosed as aplastic anemia, short-term is accepted not effect of treatments such as prednisone, leucogen, methyl testosterone, and hematochrome 4 restrains %, platelet 50,000/mm on inspection ³, leukocyte 2.000/mm ³, the sick meeting of clinical manifestation color is pale, dizziness headache, and order is stuck with paste tinnitus, heart beating is breathed hard, spiritlessness and weakness, soreness of waist and knee joint, the difficult dreaminess of sleeping, forgetful, extremity skin has petechia, the pale tongue tongue is greasy in vain, and stringy,thready and rapid pulse is unable, take 15 doses of medicines of the present invention after its disease take effect, stop blood transfusion, took medicine continuously 3 months again thereafter, all diseases in back of taking medicine disappear, the color chemical examination is normal, hale and hearty, resumes work.

Case two: Zhang Hua, the man, 21 years old, the student, in February, 2002 is because of general weakness, shortness of breath and palpitation, indigestion and loss of appetite, lusterless complexion, dryness of the tongue, white and thin fur, the petechia appears in whole body, at Chinese medical university lab testing: hemoglobin 4 gram %, leukocyte 2.500/mm ³, erythrocyte 1,500,000/mm ³, platelet 30,000/mm ³, the bone marrow aspiration inspection is diagnosed as aplastic anemia, and is invalid through multi-treatment, begin to take 15 doses of medicines of the present invention in January, 2003 after the state of an illness be clearly better, continuously take medicine 4 courses of treatment state of an illness rehabilitation.Return school's reading in JIUYUE, 2003.

Case three: Li Chunying, man, 15 years old, student, in May, 2003 because of heart beating, breathe hard, dizzy, inappetence, lassitude, pale complexion, lip is light red etc., and symptom is gone to the diagnosis and treatment of Chinese medical university, through the bone marrow aspiration inspection, be diagnosed as aplastic anemia, hemogram: erythrocyte 2,600,000/mm ³, leukocyte 4.000/mm ³, haemachrome 50%, platelet 5.5 ten thousand/mm ³, invalid through multi-treatment, need enrich blood 2 times in every month, after the state of an illness takes a favorable turn after taking 30 doses of medicines of the present invention, continuous taking medicine 2 courses of treatment, disease is rehabilitation.Return school's reading in JIUYUE, 2003.

In sum: use the medicine of treatment aplastic anemia of the present invention, patient's 350 examples, 314 examples of wherein fully recovering, produce effects 16 examples, effective 11 examples, invalid 9 examples, cure rate 89.7%, obvious effective rate 4.6%, effective percentage 3.1%, total effective rate are 97.4%.

Embodiment 1:

The medicine of treatment aplastic anemia: it is made up of the component of following weight proportion: Radix Codonopsis 30g, Rhizoma Atractylodis Macrocephalae (parched) 15g, Radix Astragali Mongolici (processed) 60g, Radix Angelicae Sinensis 15g, Radix Rehmanniae Preparata 30g, Radix Glycyrrhizae Preparata 6g, Radix Aconiti Lateralis Preparata 20g, Herba Agrimoniae 30g, Caulis Spatholobi 30g, Radix Notoginseng 5g, Radix Aucklandiae (Radix Vladimiriae) 6g, Colla cornus cervi 15g, Colla Corii Asini 15g, Colla Plastri Testudinis 15g, Cortex Moutan 10g, Radix Rehmanniae 30g.

Using method: said medicine is decocted in water for oral dose according to a conventional method, and potion divided and took for three times every day.

Embodiment 2:

The medicine of treatment aplastic anemia: it is made up of the component of following weight proportion: Radix Codonopsis 35g, Rhizoma Atractylodis Macrocephalae (parched) 20g, Radix Astragali Mongolici (processed) 60g, Radix Angelicae Sinensis 20g, Radix Rehmanniae Preparata 40g, Radix Glycyrrhizae Preparata 10g, Radix Aconiti Lateralis Preparata 30g, Herba Agrimoniae 40g, Caulis Spatholobi 35g, Radix Notoginseng 8g, Radix Aucklandiae (Radix Vladimiriae) 10g, Colla cornus cervi 20g, Colla Corii Asini 25g, Colla Plastri Testudinis 20g, Cortex Moutan 15g, Radix Rehmanniae 30g.

Using method: said medicine is decocted in water for oral dose according to a conventional method, and potion divided and took for three times every day.

Embodiment 3:

The medicine of treatment aplastic anemia: it is made up of the component of following weight proportion: Radix Codonopsis 45g, Rhizoma Atractylodis Macrocephalae (parched) 30g, Radix Astragali Mongolici (processed) 80g, Radix Angelicae Sinensis 30g, Radix Rehmanniae Preparata 50g, Radix Glycyrrhizae Preparata 15g, Radix Aconiti Lateralis Preparata 35g, Herba Agrimoniae 40g, Caulis Spatholobi 45g, Radix Notoginseng 15g, Radix Aucklandiae (Radix Vladimiriae) 15g, Colla cornus cervi 25g, Colla Corii Asini 30g, Colla Plastri Testudinis 30g, Cortex Moutan 20g, Radix Rehmanniae 32g.

Using method: said medicine is decocted in water for oral dose according to a conventional method, and potion divided and took for three times every day.

Embodiment 4:

The medicine of treatment aplastic anemia: it is made up of the component of following weight proportion: Radix Codonopsis 40g, Rhizoma Atractylodis Macrocephalae (parched) 25g, Radix Astragali Mongolici (processed) 70g, Radix Angelicae Sinensis 25g, Radix Rehmanniae Preparata 45g, Radix Glycyrrhizae Preparata 8g, Radix Aconiti Lateralis Preparata 25g, Herba Agrimoniae 35g, Caulis Spatholobi 50g, Radix Notoginseng 10g, Radix Aucklandiae (Radix Vladimiriae) 8g, Colla cornus cervi 15g, Colla Corii Asini 20g, Colla Plastri Testudinis 20g, Cortex Moutan 12g, Radix Rehmanniae 35g.

Using method: said medicine is decocted in water for oral dose according to a conventional method, and potion divided and took for three times every day.

Claims (1)

1, the medicine of treatment aplastic anemia, it is characterized in that: it is made up of the component of following parts by weight proportioning:

Radix Codonopsis 30～45, Rhizoma Atractylodis Macrocephalae (parched) 15～30, Radix Astragali Mongolici (processed) 60～80, Radix Angelicae Sinensis 15～30, Radix Rehmanniae Preparata 30～50, Radix Glycyrrhizae Preparata 6～15, Radix Aconiti Lateralis Preparata 20～35, Herba Agrimoniae 30～45, Caulis Spatholobi 30～50, Radix Notoginseng 5～15, Radix Aucklandiae (Radix Vladimiriae) 6～15, Colla cornus cervi 15～30, Colla Corii Asini 15～30, Colla Plastri Testudinis 15～30, Cortex Moutan 10～20, the Radix Rehmanniae 30～35.