CN103055147B - That treats chronic aplastic anemia sticks medicine and preparation method thereof - Google Patents
That treats chronic aplastic anemia sticks medicine and preparation method thereof Download PDFInfo
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- CN103055147B CN103055147B CN201310004703.7A CN201310004703A CN103055147B CN 103055147 B CN103055147 B CN 103055147B CN 201310004703 A CN201310004703 A CN 201310004703A CN 103055147 B CN103055147 B CN 103055147B
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Abstract
That treats chronic aplastic anemia sticks medicine, it is characterized in that pasting medicine by the deficiency of YIN forms; Be prepared into by Radix Rehmanniae Preparata 25-35g, Colla Plastri Testudinis 25-35g, Radix Angelicae Sinensis 10-20g, Colla Corii Asini 10-20g, Radix Notoginseng 3-6g and Pseudobulbus Bletillae (Rhizoma Bletillae) 3-6g.The advantages such as patent of the present invention has easy to use, good effect, and side effect is little.<b />
Description
Technical field
The present invention relates to one and stick Chinese medicine, particularly relate to treat chronic aplastic anemia stick medicine and preparation method, during use, this plaster spreads on SHENYU point.
Background technology
Chronic aplastic anemia (is called for short chronic aplastic anemia, chronic aplastic anemia, CAA) because the many factors such as physics, chemistry, biology cause hemopoietic function of bone marrow to subtract the disease of exhaustion, pancytopenia, commonly encountered diseases and the frequently-occurring disease of blood system, at China's sickness rate 6.1/10 ten thousand, account for 12% of disease in the blood system.Its clinical manifestation is anemia, hemorrhage, infection, and based on anemia, its onset is hidden, make slow progress, course of disease delay is difficult heals, and can alleviate, very easily recur though treatment is rear.At present, western medical treatment chronic aplastic anemia many employings androgen, immunosuppressant, hematopoietic cell growth factor etc., although evident in efficacy, but the unstability of its curative effect and drug side effect thereof, as liver, nephrotoxicity, gastrointestinal reaction, virilization etc., have a strong impact on existence and the quality of life of patient.Though TCM Document, without this name of disease of chronic aplastic anemia, belongs to the category of " blood deficiency " " asthenia " according to its clinical symptoms, there is it to its treatment, the Systematic therapy scheme centered by kidney that modern times are formed from ancient times.Kidney governing bones, raw marrow, store essential substances, although essence and blood sharing the same origin theory thinks that aplastic anemia shows as QI and blood deficiency, but it is kidney at all, deficiency of kidney-essence, kidney is store essential substances, raw marrow not, oligospermia does not change blood, marrow not hemopoietic and cause that this is sick less, and defines the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs system centered by kidney gradually, and kidney tonifying, essence replenishing, blood-nourishing blood-generating are its base therapy principles.Chinese medicine participates in chronic aplastic anemia treatment and all demonstrate obvious curative effects in clinical practice and experimentation, and low price, more easily accepted by patient.Modern experimental research shows, kidney-nourishing tcm drug all can promote that in bone marrow, hematopoietic progenitor population forms unit (CFU-F) propagation, hemopoietic stem cell growth; Simultaneously by suppressing short apoptosis factor as lowered the expression of Fas albumen, suppress the activity of Key kinases Casasse-3, or increase anti-apoptotic factor as increased bone marrow CD34+ cell bcl-2 protein expression, coordinate the apoptosis of Hematopoietic Stem/group cell, thus recover hemopoietic function of bone marrow.Strengthening spleen, tonifying kidney Chinese medicine promotes bone marrow hematogenesis by improving immunologic function, and it can improve the ratio of T lymphocyte subgroup, and CD4+/CD8+ returns to normal level, suppress Ts function, increase NK cytoactive, reduce hemopoietic negative regulatory factor TNF-α simultaneously, 1FN-γ, the releases such as IL-2.Blood-activating and stasis-removing is then by promoting marrow fibroblast, and hematopoietic progenitor population forms unit (CFU-F), CFU-E (CFU-E) propagation, improves hematopoiesis microcirculation, accelerates metabolism, promote bone marrow regeneration.
Summary of the invention
Object of the present invention, be open treatment chronic aplastic anemia stick medicine, this medicine is easy to use, good effect, and side effect is little.
Another object of the present invention, is to provide a kind of preparation method of this medicine.
The technical scheme adopted is:
That treats chronic aplastic anemia sticks medicine, it is characterized in that pasting medicine by the deficiency of YIN forms.
The deficiency of YIN pastes medicine, is be prepared into by Radix Rehmanniae Preparata 25-35g, Colla Plastri Testudinis 25-35g, Radix Angelicae Sinensis 10-20g, Colla Corii Asini 10-20g, Radix Notoginseng 3-6g and Pseudobulbus Bletillae (Rhizoma Bletillae) 3-6g.
The preparation method sticking medicine for the treatment of chronic aplastic anemia, comprises the steps:
1, get the raw materials ready:
Get Radix Rehmanniae Preparata, Colla Plastri Testudinis, Radix Angelicae Sinensis, Colla Corii Asini, Radix Notoginseng and the Pseudobulbus Bletillae (Rhizoma Bletillae), dry respectively, be ground into fine powder, cross 200 mesh sieves, splendid attire is for subsequent use respectively.
2, prepare the deficiency of YIN and paste medicine:
Get Radix Rehmanniae Preparata powder 25-35g, Carapax Et Plastrum Testudinis rubber powder 25-35g, Radix Angelicae Sinensis powder 10-20g, Colla Corii Asini powder 10-20g, Radix Notoginseng powder 3-6g and Pseudobulbus Bletillae (Rhizoma Bletillae) powder 3-6g, be mixed even, obtain final product.
The using method sticking medicine for the treatment of chronic aplastic anemia of the present invention:
Select SHENYU point for sticking a little, get the deficiency of YIN and paste medicine 6.6g, add 4ml distilled water and make paste, be placed in diameter 2.5cm plaster central authorities and stick in groove, plaster is accurately affixed on bilateral SHENYU point, give TDP irradiation and stick position 30 minutes, sticking lasting 6-8 hour, once a day, 15 days was 1 course for the treatment of, annual application 4 course for the treatment of (Spring Equinox, the Summer Solstice, the Autumnal Equinox, Winter Solstice), continuous application 3 years.Deficiency of the kidney yin person paste by the deficiency of YIN; Whenever the Summer Solstice (when the Summer Solstice cloudy life of beginning), all patients all paste 3 days to play the subsides deficiency of YIN same day in the Summer Solstice.
Inventor is according to the experience of more than 30 years treatment chronic aplastic anemia, invent chronic aplastic anemia shen shu application therapy, this therapy is under the guidance of traditional Chinese medical science inner disease outer treat theory, for chronic aplastic anemia etiology and pathogenesis, dialectically to combine with differential diagnosis of diseases, select medicine prescription with kidney tonifying, essence replenishing, blood-nourishing blood-generating for principle, theoretical in conjunction with tcm time medicine theory, meridional point, select to treat between Winter Solstice and midsummer, give full play to the Comprehensive Treatment effect of chronotherapy, pharmacotherapy, acupoint therapy.By clinical observation, chronic aplastic anemia shen shu application therapy is safe and effective, cheap.
Fang Xie
1. the deficiency of YIN is pasted with Radix Rehmanniae Preparata, Colla Plastri Testudinis as monarch drug
The sweet tepor of Radix Rehmanniae Preparata, enter Liver and kidney and the special nourishing the blood and yin of merit, life essence-filling, marrow-benefitting is the key medicine of tonifying kidney-yin." medicineization justice " cloud: Radix Rehmanniae Preparata settling five organs, and blood vessels, profit skin, nourishing the heart to keep a sound mind, peaceful soul, nourishes Kidney-Yin, packing bone marrow, for panacea also. " Radix Rehmanniae Preparata sweet Wen Zhirun is described, nourishing YIN benefit is smart in hemopoietic, has the merit of the tonify deficiency that nourishes blood.Colla Plastri Testudinis, salty in the mouth, sweet cold nature, returns liver, kidney, heart channel, has effect of nourishing YIN for suppressing the hyperactive YANG, replenishing kidney and strengthening bone, reinforcing the heart of nourishing blood." book on Chinese herbal medicine covers bamboo fish trap " records Carapax Et Plastrum Testudinis energy " special nourishing YIN declines, and kind nourishing kidney is damaged "." Ling Shu Miraculous Pivot or Divine Axis carbuncle " cloud: " body fluid and tune, change and red be blood ".Illustrate that Colla Plastri Testudinis is by nourishing cloudy essence to treat the cloudy thanks to all diseases of blood deficiency.
With Radix Angelicae Sinensis, Colla Corii Asini enriching yin and nourishing kidney, blood-nourishing blood-generating is ministerial drug altogether.Enrich blood with Pseudobulbus Bletillae (Rhizoma Bletillae), pseudo-ginseng blood-circulation-invigovating, promoting tissue regeneration by removing blood stasis, and help all medicine drug effects thoroughly to reach skin texture, be adjuvant altogether.All medicines share plays enriching yin and nourishing kidney altogether, and beneficial essence fills out the merit of marrow, the treatment chronic aplastic anemia person that is partial to deficiency of the kidney yin.
2. modern pharmacological research
Radix Rehmanniae Preparata: its principle active component is prepared rehmannia root polysaccharide, this composition has the effect promoting bone marrow hematogenesis and excitement immunity, its mechanism may be by promoting to induce after IL-1 secretion in serum grain-huge to bite transcribing of fine colony stimulating factor, or produce grain-huge by induction T cell after promoting IL-2 secretion and bite fine colony stimulating factor, grain-huge is bitten fine colony stimulating factor and can be maintained hemopoietic forebody cell and mature erythrocyte (neutrophilic granulocyte, eosinophilic granulocyte and mononuclear phagocyte) survival, promote hemopoietic forebody cell (mononuclear cell, granulocyte and megalokaryocyte) proliferation and differentiation, strengthen the phagocytic function of neutrophilic granulocyte and macrophage.
Colla Plastri Testudinis active component is various colloid, keratin, steroidal compounds and a small amount of trace element; it can leukocyte increasing, platelet, hemoglobin content; reticuloendothelial phagocytic function can also be strengthened; improve immunity of organisms infection control; anemia, shortens the bleeding time caused by wound, also has enhancing development; defying age, the effect of protection central nervous system.
Radix Angelicae Sinensis: main component is volatile oil, organic acid, fructose, polysaccharide, vitamin etc.Its anti-anemia effect is mainly because Radix Angelicae Sinensis polysaccharide can stimulate the bone marrow macrophage in hemopoietic inductive microenviroment, secrete and the synthesis hematopoietic regulation factor from gene and protein level, promote that polyphyly hemopoietic progenitor cell is as the proliferation and differentiation of CFU-Mix, CFU-E, CFU-GM etc., stimulate bone marrow hematogenesis, wherein contained in Radix Angelicae Sinensis vitamin B12, nicotinic acid, folic acid, folinic acid are important hemopoietic raw material.In addition, when giving back, there is enhancing human body immunity function, antioxidation and scavenging free radicals, analgesia, antiinflammatory, antibacterial, the effect such as radioprotective and antibody Monoclonal.
Colla Corii Asini: its pharmacological action has been coordinated jointly by protein, aminoacid and trace element in Colla Corii Asini, its anti-anemia effect mainly possesses allos inducing properties by donkey skin extracellular matrix composition contained in Colla Corii Asini, it is by increasing hematopoietic progenitor colony BFU-E, CFU-E, CFU-GM, Liver and kidney EPO and GM-CSFmRNA is stimulated to express, improve the content of peripheral blood GM-CSF, IL-6, EPO, reduce hemopoietic negative regulatory factor INF-γ, TGF-β content, play the effect promoting bone marrow hematogenesis.In addition Colla Corii Asini also has antitumor, blood vessel dilating, improves immunity of organisms, promotes the effects such as the absorption of calcium.
The Pseudobulbus Bletillae (Rhizoma Bletillae): active component is bibenzyl, luxuriant and rich with fragrance class and derivant thereof, and volatile oil, mannan, phlegmatic temperament and glucose etc., have hemostasis, antiulcer, antibacterial, antitumor, promotes wound healing, promotes the function of vascular endothelial cell growth.In addition, in this product, volatile oil is a kind of natural penetrating agent, and the outer used time can promote that skin is to the absorption of medicine and transmission.
Radix Notoginseng: its effective ingredient is the compounds such as volatile oil, arasaponin, flavonoid glycoside, aminoacid, modern pharmacological research shows the multiple effects such as it has hemostasis, enriches blood, blood fat reducing, antiinflammatory, defying age, arrhythmia, wherein arasaponin can the multiple transcription factor of induction of hematopoiesis cell as GATA bunch, AP bunch, nuclear factor-KB etc. are from gene level regulation and control hematopoietic progenitor cell, propagation, promote hemopoietic, improve anemia.Arasaponin, dencichine are by strengthening hematoblastic viscous yielding campaign simultaneously, and material such as styptic activity such as induced platelet release ADP, arachidonic acid etc., plays the effect promoting blood coagulation.In addition, volatile oil is good penetrating agent, can promote the Transdermal absorption of medicine.
3. cave principle is selected
Theoretical according to Chinese medicine meridian acupuncture points on the human body, meridians are paths of human qi and blood running, and acupuncture points on the human body is that the QI and blood infusion of human body zang-fu differentiation is in the privileged sites of body surface.Acupuncture points on the human body belongs to each passages through which vital energy circulates, and passages through which vital energy circulates is under the jurisdiction of specific internal organs, connects each other, refinforces each other between acupuncture points on the human body, passages through which vital energy circulates, internal organs, forms an indivisible entirety.Drug effect is in acupuncture points on the human body, and by dredging the meridian, concordant remedies gas, effect through gas, QI and blood regulating, Yin Yang balancing, to reach the object of preventing and curing diseases.SHENYU acupoint comes from " Ling Shu Miraculous Pivot or Divine Axis the back of the body Yu " section, is the back shu points of kidney, belongs to bladder meridian.Under the 2nd spinous process of lumbar vertebra, 1.5 cun of places are opened on side.There is kidney tonifying supporing yang, receive the merit of gasified water, strengthening the body resistance.Cure mainly all diseases of suffering from a deficiency of the kidney.Back shu points is internal organs through the acupuncture point of gas infusion in back of the body waist, is internal organs, the exterior and the interior internal organs, affiliated histoorgan " information epitome ".Because of bladder meridian and kidney meridian phase the exterior and the interior, and waist is house of kidney, and the kidney generating marrow and dominating bone, chooses shen shu and stick, and medicine can be directly acted on kidney, play kidney tonifying marrow facilitating, the effect of spermatogenesis blood.
4. application time is selected
According to chronic aplastic anemia pathogen and pathology of tcm in conjunction with tcm time medicine thought really.Tcm time medicine thought thinks that man and nature are unified, and the vital movement rhythm and pace of moving things and the natural mechanical periodicity of people exist synchronicity.Its root of chronic aplastic anemia is in the passing of time caused negative and positive of qi and blood virtual loss of suffering from a deficiency of the kidney."Nei Jing" cloud: " kidney person master sting, the dominator of storing essence, and smart part also, is shaoyin within yin, leads in winter gas "." Plain Questions. opinion during visceral-qi method " propose: " sick at kidney, more in the spring, the spring does not heal, and is far more than the long summer, and the long summer is not dead, is held in the autumn, arises from the winter." illustrating that kidney belongs to the winter, main Tibetan, humans during winter months's yang-energy is accumulated in kidney, and now the yang-energy of kidney is the most prosperous; if yang-energy is when prosperous in kidney, and winter trembles with fear in sky, cold tending to injure YANG; then can feel evil morbidity or increase the weight of the state of an illness, therefore chronic aplastic anemia patient aggravation in winter, is even especially with relatively yang deficiency person.And summer human body kidney the moon essence abundant, if cloudy damage of essence is empty, sky thermal burn is cloudy, then can increase the weight of the state of an illness, and therefore chronic aplastic anemia patient yin asthenia generating intrinsic heat in summer symptom is obvious, is very especially to be partial to deficiency of YIN person.According to Changing Pattern free period, when being the summersolstice the annual Summer Solstice, we propose the theory of " nourishing YIN in the Summer Solstice ".Whenever the Summer Solstice, all patients all stick the deficiency of YIN paste three, giving treatment in accordance with the tendency of pathological change to rise the same day in the Summer Solstice, strengthen kidney invigorating and YANG supporting, effect of YIN nourishing benefit marrow.On ordinary days partially decline according to patient is yin or yang excess, give to stick agent accordingly.
The advantages such as patent of the present invention has easy to use, good effect, and side effect is little.
Detailed description of the invention
Embodiment one
That treats chronic aplastic anemia sticks medicine, pastes medicine form by the deficiency of YIN.
The deficiency of YIN pastes medicine, is be prepared into by Radix Rehmanniae Preparata 30g, Colla Plastri Testudinis 30g, Radix Angelicae Sinensis 15g, Colla Corii Asini 15g, Radix Notoginseng 5g and Pseudobulbus Bletillae (Rhizoma Bletillae) 5g.
Embodiment two
That treats chronic aplastic anemia sticks medicine, pastes medicine form by the deficiency of YIN.
The deficiency of YIN pastes medicine, is be prepared into by Radix Rehmanniae Preparata 25g, Colla Plastri Testudinis 25g, Radix Angelicae Sinensis 10g, Colla Corii Asini 10g, Radix Notoginseng 3g and Pseudobulbus Bletillae (Rhizoma Bletillae) 5g.
Embodiment three
That treats chronic aplastic anemia sticks medicine, pastes medicine form by the deficiency of YIN.
The deficiency of YIN pastes medicine, is be prepared into by Radix Rehmanniae Preparata 35g, Colla Plastri Testudinis 35g, Radix Angelicae Sinensis 20g, Colla Corii Asini 20g, Radix Notoginseng 6g and Pseudobulbus Bletillae (Rhizoma Bletillae) 3g.
Claims (3)
1. that treats chronic aplastic anemia sticks medicine, it is characterized in that pasting medicine by the deficiency of YIN forms;
The deficiency of YIN pastes medicine, is be prepared into by Radix Rehmanniae Preparata 25-35g, Colla Plastri Testudinis 25-35g, Radix Angelicae Sinensis 10-20g, Colla Corii Asini 10-20g, Radix Notoginseng 3-6g and Pseudobulbus Bletillae (Rhizoma Bletillae) 3-6g.
2. treatment chronic aplastic anemia according to claim 1 stick medicine, it is characterized in that by the deficiency of YIN paste medicine form;
The deficiency of YIN pastes medicine, is be prepared into by Radix Rehmanniae Preparata 30g, Colla Plastri Testudinis 30g, Radix Angelicae Sinensis 15g, Colla Corii Asini 15g, Radix Notoginseng 5g and Pseudobulbus Bletillae (Rhizoma Bletillae) 5g.
3. the preparation method sticking medicine for the treatment of chronic aplastic anemia according to claim 1, is characterized in that comprising the steps:
(1) get the raw materials ready:
Get Radix Rehmanniae Preparata, Colla Plastri Testudinis, Radix Angelicae Sinensis, Colla Corii Asini, Radix Notoginseng and the Pseudobulbus Bletillae (Rhizoma Bletillae), dry respectively, be ground into fine powder, cross 200 mesh sieves, splendid attire is for subsequent use respectively;
(2) prepare the deficiency of YIN and paste medicine:
Get Radix Rehmanniae Preparata powder 25-35g, Carapax Et Plastrum Testudinis rubber powder 25-35g, Radix Angelicae Sinensis powder 10-20g, Colla Corii Asini powder 10-20g, Radix Notoginseng powder 3-6g and Pseudobulbus Bletillae (Rhizoma Bletillae) powder 3-6g, be mixed even, obtain final product.
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| CN104000942A (en) * | 2014-05-18 | 2014-08-27 | 陈洪佳 | Mixed traditional Chinese medicine for treating aplastic anemia |
| CN104524254A (en) * | 2014-12-08 | 2015-04-22 | 吕凤荣 | Qi failing to control blood type "aplastic anemia" spleen tonifying and kidney invigorating preparation and preparation method thereof |
| CN104544046B (en) * | 2014-12-11 | 2016-12-07 | 江苏古月楼餐饮有限公司 | A kind of woman's steamed dumping stuffing material and the manufacture method of woman's steamed dumping |
Citations (4)
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|---|---|---|---|---|
| CN1137393A (en) * | 1995-06-08 | 1996-12-11 | 孟涛 | Yisuishengxue Chinese medicine preparation for tonifying marrow and promoting generation of blood |
| CN1840006A (en) * | 2006-01-26 | 2006-10-04 | 周伟 | Medicine for treating aplastic anemia |
| CN101391056A (en) * | 2008-10-23 | 2009-03-25 | 王湛 | Medicine for treating aplastic anemia |
| CN102205051A (en) * | 2011-05-20 | 2011-10-05 | 韩丹艳 | Notoginseng root hematogenic medicament and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1137393A (en) * | 1995-06-08 | 1996-12-11 | 孟涛 | Yisuishengxue Chinese medicine preparation for tonifying marrow and promoting generation of blood |
| CN1840006A (en) * | 2006-01-26 | 2006-10-04 | 周伟 | Medicine for treating aplastic anemia |
| CN101391056A (en) * | 2008-10-23 | 2009-03-25 | 王湛 | Medicine for treating aplastic anemia |
| CN102205051A (en) * | 2011-05-20 | 2011-10-05 | 韩丹艳 | Notoginseng root hematogenic medicament and preparation method thereof |
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