CN1528261A - Shampoo for treating white hair and lipso trichia and eliminating toxicant and preparing method thereof - Google Patents

Abstract

The present invention discloses a shampoo capable of curing poliosis, baldness and discharging toxic material and its preparation method. It is made up by using the Chinese medicinal materials of flavescent sophora root, dahurian angelica root, arctium root, ledebourielkla root, aconite/typhonium tuber and AES and water through the processes of weighing, decocting, filtering and stirring. Said shampoo can obtain stable and reliable therapeutic effect, and has no any toxic side effect.

Description

A kind of hair cream for the treatment of the hoariness and alopecia toxin expelling and preparation method thereof

One, technical field

The invention belongs to Chinese medicine hair cream technical field, especially relate to hair cream of a kind of hoariness and alopecia toxin expelling and preparation method thereof.

Two, background technology

Because the quickening of present social life rhythm and environment, artificial factor, people's living poliosis situation is commonplace and multiple, present treatment for poliosis, be divided into short-term and long-term treatment, short term therapy just is to use and dyes method agent hair dyeing, and this method is cured the symptoms, not the disease, and hair dye contains chemical drugs, it has certain toxicity, and the life-time service injury is healthy; Oral vitamin B1, calcium pantothenate etc. are adopted in long-term treatment, and the course of treatment is very long and curative effect is bad; The treatment by Chinese herbs poliosis adopts method for oral administration, as Radix Polygoni Multiflori tablet bazhen yimu pills, bazhen yimu wan, Ginseng Bolus for Tonification, LIUWEI DIHUANG WAN etc., this method is relatively good, the hair caring that can take care of health, but the growth cycle of hair is generally 2-6,4-5 month resting stage, the natural on-off cycles of hair growth phase that has can continue 25 years, persistent taking, expense are than higher, and uncertain therapeutic efficacy is fixed.

Alopecia also is puzzlement people's a great problem at present, the medicine liquor ratio of existing treatment alopecia is more, as to treat alopecia areata be that a stimulating hair growth is a principle, oral medicine has Alopecia Pill, vitamin B1, B6, B12, cystine, functions of nourishing hair and growing hair capsule etc., medicine for external use has 20% psoralea tincture, the Rhizoma Zingiberis Recens tincture, speckle insect destructive of the roots of seedlings tincture, capsicum tincture, the treatment of ultraviolet black light is adopted in physical therapy, 101 HAIR REGENERATING MEDICINE, 118 hair regenerating tonics etc., other acupuncture, ear acupuncture, percussopunctator etc., the method that these methods have is relatively good, the picture Alopecia Pill, 101 HAIR REGENERATING MEDICINE can reach hair growth promoting, hair care, maintenance hair scalp tissue, but the course of treatment is also long, expense is higher, and curative effect is relatively good.

Hair dyeing is popular at present, but can on scalp, catch harmful substance after the hair dyeing, the people of especially long-term hair dyeing forms allergic constitution easily, and is of common occurrence as the hair dyeing dermatitis, grievous injury people healthy, for these problems, just adopt Claritin for oral administration at present, alleviate allergic symptom, but enter the harmful substance in the human body scalp, still can't get rid of.

Three, summary of the invention

The objective of the invention is to improve prior art not enough and provide a kind of stable curative effect definite, effective, have no side effect, the treatment hoariness and alopecia hair cream of short treating period and preparation method thereof.

The object of the present invention is achieved like this, and a kind of hair cream for the treatment of the hoariness and alopecia toxin expelling is characterized in being made up of following weight portion medicine: Radix Sophorae Flavescentis 2-7 part, Radix Angelicae Dahuricae 2.5-9 part, Fructus Arctii 2-7 part, Radix Saposhnikoviae 1-4 part, Rhizoma Typhonii 0.2-7 part, Fructus Kochiae 2-8 part, Fructus Ligustri Lucidi 2-8 part, Radix Angelicae Sinensis 0.8-7 part, Radix Dipsaci 1-4 part, Rhizoma Ligustici 0.8-3 part, Radix Polygoni Multiflori 2-9 part, Herba Ecliptae 2-8 part, Cortex Cinnamomi 1-4 part, Cortex Magnoliae Officinalis 1-4 part, Fructus Psoraleae 0.8-6 part, Radix Aconiti Kusnezoffii 0.8-3 part, Radix Achyranthis Bidentatae 2-7 part, Radix Paeoniae Alba (parched) 0.9-7 part, Folium Mori 0.8-6 part, Pericarpium Citri Reticulatae 0.9-7 part, salt 5-12 part, AES5-12 part, water 50-300 part.

In order to realize purpose of the present invention, the present invention adopts the preparation of following steps method:

A, to take by weighing required medicine standby;

B, with outside the medicine desalination and AES that weigh up, other medicines are positioned over soaks 1-2 hour in the container;

C, water is boiled with slow fire opened the back after 15-20 minute, and medicine soup is filtered out, and was positioned in another container;

D, step c three times repeatedly;

After e, the medicine soup mixing, filter, obtain filtrate with the 80-100 mesh filter screen with three acquisitions;

F, filtrate precipitated 1-2 hour after, disgorging;

G, twice sedimentation and filtration repeatedly obtain filtrate;

H, filtrate is added AES, stir to a direction, until no AES piece;

I, filtrate cold add salt during to room temperature, stir into even paste to a direction and get final product.

In order further to realize purpose of the present invention, used container can be aluminum matter, rustless steel or container made of iron among the step b.

Radix Sophorae Flavescentis, cold in nature, bitter in the mouth, return liver, stomach, large intestine, the heart, kidney, urinary bladder channel, have heat clearing and damp drying, eliminating fire and detoxication, killing parasites for relieving itching, diuretic function, be used for hygropyretic dysentery, the jaundice of having loose bowels, damp-heat accumulation, dysuria edema, discharging fresh blood stool, bleeding hemorrhoids, skin flea are itched, eczema, eczema, blood tinea corporis skin ulcer, naughty white-browed; Toxicity test, to the effect of cardiovascular system, lightyellow sophora root injection can make decreased heart rate in stripped Bufo siccus and the test of rabbit cardiac perfusion, and myocardial contraction weakens; Antiinflammatory action, mouse subcutaneous injection matrine can make that the abdominal cavity inflammatory exudation reduces due to the acetic acid, and matrine is penetrated in the rat intramuscular injection has obvious inhibition to the Ovum Gallus domesticus album foot is swollen, and continuous use 6d also has obvious inhibition to granuloma induced by implantation of cotton pellets; Antiallergic, relieving asthma, phlegm-dispelling functions, matrine can suppress the passive and skin allergy initiatively of animal, can reduce the sensitized animal serum antibody and form, and the allergic asthma due to the histamine is had stronger antagonism.

The Radix Angelicae Dahuricae, warm in nature, acrid in the mouth is returned lung, spleen, stomach warp, has expelling wind and removing dampness, understand things pain-stopping, detumescence and apocenosis function; Be used for all pains of women's head-ornaments that ailment said due to cold or exposure causes, clear sun sink, the dairrhea caused by pathogenic damp chronic diarrhea of cold-damp damaging the spleen and stomach, and the carbuncle abscess, cold syndrome such as the sombre multiple abscess of carbuncle of yin nature carbuncle on the back then are suitable for the same usefulness of warming YANG cold-dispelling drug such as Aconitum carmichjaelii Debx., Cortex Cinnamomi, and the skin Pruritus is often joined Radix Paeoniae Alba nourishing blood to expel wind; Toxicity test, analgesic, analgesia and antiinflammatory action, the Radix Angelicae Dahuricae or Radix angelicae dahuricae decoct are irritated stomach, the rabbit that generates heat due to the egg peptone is descended to inject in the back trivial solution heat effect is arranged, the antipathogen effect, the Radix Angelicae Dahuricae external to escherichia coli, Bacillus typhi, bacillus pyocyaneus etc. have inhibitory action in various degree, decoct has in various degree inhibitory action to fungus that Trichophyton concentricunm causes a disease, one of Radix Angelicae Dahuricae photochemotherapy treatment psoriasis mechanism, may be that the DNA that suppresses the psoriasis epidermis cell synthesizes, make the normal rate of increase of psoriasis epidermis cellular-restoring of rapid propagation, thereby skin lesion is cured, pigment increases.

Fructus Arctii (parched), cool in nature, acrid in the mouth, hardship attach to the lung and stomach meridians, and have the function of dispelling wind and heat pathogens, lung qi dispersing rash, clearing throat, removing toxic substances and promoting subsidence of swelling; Be used for the fever and aversion to wind due to the affection due to external wind and heat, disease such as headache cough grade, at the measles initial stage, rash goes out freely not reach the wind heat urticaria, skin pruritus, the scarlet fever due to the hyperactivity of toxic heat, macule can be joined removing pathogenic heat from blood and toxic substance from the body such as Radix Arnebiae (Radix Lithospermi), Rhizoma Cimicifugae, heat clearing away expelling pathogenic factors from the exterior; Toxicity test, antibiosis and antiviral functions, Fructus Arctii immersion (1: 2) is permitted blue achorion in vitro to Trichophyton concentricunm, and pathomycetes such as epidermophyton inguinale have inhibitory action, and Fructus Arctii extract has anti AIDS virus (HIV) activity.

The Fructus Kochiae, cold in nature, bitter in the mouth, return kidney, urinary bladder channel, have clearing away heat and promoting diuresis, removing damp to relieve itching, be used for gonorrhea, edema leukorrhagia, control damp-heat in the urinary bladder; the puckery pain of dribbling urination, skin eczema eczema, skin pruritus; can join Radix Saposhnikoviae; it is for oral administration both can to have fried in shallow oil soup, also can be used for washout, wash skin wind, heat and order ends and moistening; Toxicity test, antibacterial action, the infusion of 1: 2 concentration of the Fructus Kochiae are in vitro all had in various degree inhibitory action to permitting dermatophytess such as blue achorion, rust microspore's tinea bacterium, ulotrichy microspore's tinea bacterium.

Radix Saposhnikoviae, warm in nature, acrid in the mouth, sweet is returned bladder, lung, spleen channel, has expelling pathogenic wind from the body surface, the function of pain relieving spasmolytic is the key medicine of dispeling the wind, and is used for exterior syndrome due to wind-cold, headache general pain, tetanus and infantile convulsion, control skin ulcer, the rash that disappears, all available this dispelling wind for relieving itching of skin pruritus, wind is contained and is joined Fructus Atriplicis Sibiricae, Cortex Dictamni, wet Sheng is joined Rhizoma Atractylodis; Toxicity test, refrigeration function, decoct, preserved material is irritated stomach to heating rabbit agent injection lumbar injection due to the typhoid fever polyvalent vaccine, to triple vaccine (pertussis, diphtheria, tetanus) the heating rabbit all has moderate or trivial solution heat effect due to, anti-inflammatory and analgesic effect, decoct and ethanol preserved material gavage, rat Ovum Gallus domesticus album swelling of the feet had certain inhibitory action, to Immune Effects, anti-edema due to wind pathogen extract significantly improves the phagocytic percentage and the phagocytic index of Turnover of Mouse Peritoneal Macrophages, and can resist the inhibitory action of hydrocortisone to phagocytic function, obviously increase the weight of mice, effect with enhancing human body immunity function, Radix Saposhnikoviae is for multiple dysentery bacterium, Hemolytic streptococcus also has inhibitory action in various degree.

Rhizoma Typhonii, warm in nature, acrid in the mouth, slightly poisonous, return liver, stomach warp, have the expectorant of dispeling the wind, the arresting convulsion epilepsy, eliminating stagnation, the antidotal function is used for the wind-phlegm appoplexy involving the collateral, tetanus, oral administration and externally can be controlled tuberculous lymphadenitis, carbuncle furuncle, venom; Toxicity test, the anti-mycobacterium tuberculosis effect, injection has certain therapeutical effect to infecting the Bacillus tuberculosis Cavia porcellus, and its curative effect is only second to streptomycin, the anticoagulant effect, Rhizoma Typhonii has remarkable antithrombase effect.

Fructus Ligustri Lucidi, cool in nature, sweet in the mouth, hardship are returned liver, kidney channel, have nourishing YIN and clearing away heat, the function of the black hair that makes eye bright; The soreness of the waist and knees that is used for the hepatic and renal YIN deficiency, dizzy tinnitus order flower, early whitening of beard and hair has effect in increasing leukocyte, also uses the leukopenia of Chronic Benzene Poisoning and caused by radiotherapy and chemotherapy, acute, chronic hepatitis and hyperlipidemia etc.; Toxicity test, to Immune Effects, increase immune organ weight, the Fructus Ligustri Lucidi water decoction is irritated stomach, can make mouse thymus, spleen weight obviously increases, strengthen humoral immune function, the Fructus Ligustri Lucidi decoct is irritated stomach can obviously improve the serum antibody activity, rising normal serum Igc content, improve cellular immune function, the Fructus Ligustri Lucidi water extract is at an amount of phytohaemagglutinin of external obvious enhancing (PHA), and water extract is stronger than ethanol extract effect, suppress allergy, the Fructus Ligustri Lucidi decoct is irritated stomach and is obviously suppressed mice passive cutaneous anaphylaxis, PCA (PCA), reduce rat pericranium mast cell degranulation percentage rate, the rat skin capillary permeability that antihistamine is caused increases, administration before antigen is attacked, oleanolic acid is that Fructus Ligustri Lucidi suppresses allergic main effective ingredient, to the influence of hemopoietic system, adopt diffusion chamber plasma clot method to confirm, Fructus Ligustri Lucidi medicinal liquid subcutaneous injection can promote mice erythroid hematopoiesis cell (CFU-E) growth, is that CFU-GM (CFU-D) but obviously reduces to grain, illustrate that Fructus Ligustri Lucidi has facilitation to erythroid hematopoiesis, Fructus Ligustri Lucidi is very little to animal toxicity, and rabbit is once obeyed fresh mature fruit 75 grams, does not see intoxicating phenomenon.

Radix Angelicae Sinensis, warm in nature, sweet in the mouth, suffering are returned liver, the heart, spleen channel, and having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the function of loosening bowel to relieve constipation is used for that blood deficiency is had a dizzy spell, stops in the shallow complexion, congestion, blood deficiency is held concurrently all kinds of pain card of the stasis of blood; Toxicity test, influence to blood and hemopoietic system, anticoagulant and antithrombotic form, influence to hemopoietic system, Radix Angelicae Sinensis polysaccharide is to the erythrocyte of anemia mice, hemoglobin, leukocyte and femur nucleated cell number recover to have obvious facilitation, multi-functional hemopoietic stem cell proliferation there is the significant stimulation effect, blood vessel dilating, bring high blood pressure down, Radix Angelicae Sinensis can be expanded peripheral blood vessel, reduce resistance, increase flow, this is relevant with excited cholinoceptor and histamine receptor, anti-inflammatory and analgesic effect, the Radix Angelicae Sinensis water decoction all has the obvious suppression effect to the acute and chronic disease that multiple proinflammatory agent causes, anti-microbial effect, and Radix Angelicae Sinensis volatile oil is to staphylococcus aureus, escherichia coli, shigella flexneri, prevention administration of infecting mouses such as bacillus pyocyaneus or treatment all have antibacterial action.

Radix Dipsaci, slightly warm in nature, bitter in the mouth, suffering, little puckery, return liver, kidney channel, have invigorating the liver and kidney, the nourishing muscle and tendon bone, get round by bribery, and blood vessels, antiabortive hemostatic function, be used for lumbago due to renal deficiency, the foot and knee being feeble, and blood vessels, antiabortive hemostasis, traumatic injury is in carbuncle ulcer Fang Zhongjia this product, the enhancing detumescence and apocenosis is arranged, the promoting regeneration of the tissue and arresting bleeding effect; Toxicity test, the Radix Dipsaci water decoction is irritated stomach, can improve the mice hypoxia-bearing capability, prolong the mice swimming with a load attached to the body persistent period, promote the mouse macrophage phagocytic activity, flavone component in the Radix Dipsaci has antioxidant activity and antiinflammatory action, and the effect of vitamin antagonist E deficiency disease is arranged, and streptococcus pneumoniae is had inhibitory action.

Rhizoma Ligustici, warm in nature, acrid in the mouth is returned urinary bladder channel, has the function of dispersing wind-cold, damp-clearing pain-relieving, is used for headache and parietal headache, cold, stagnation of cold-damp in middle-JIAO, external also can be treated dermatosiss such as scabies, acne; Toxicity test, ligustilide is to the effect of breathing heavily that causes to Cavia porcellus of antihistamine and acetylcholine, and can may be direct effect to the inhibitory action of Cavia porcellus smooth muscle to antihistamine, acetylcholine or barium chloride, typhoid fever, paratyphoid fever polyvalent vaccine are caused that the rabbit of heating has the trivial solution heat effect, and can reduce the normal body temperature of mice, show significant calmness is arranged, central inhibitory action such as analgesia, analgesic and cooling.

Radix Polygoni Multiflori, slightly warm in nature, bitter in the mouth, sweet, puckery is returned liver, kidney channel, has that nourishing YIN is nourished blood, a function of detoxifcation, loosening bowel to relieve constipation, is used for deficiency of the liver and kindey, and essence and blood is empty to be lost, rubella, skin pruritus due to the hyperactivity of YANG due to deficiency of YIN, blood deficiency and depleted fluid, carbuncle sore tumefacting virus, wind syndrome due to dryness of blood; Toxicity test, slow down aging, Radix Polygoni Multiflori and preparation thereof can prolong the growth cycle of diploid cell, the contained vegetable lecithin that enriches of Radix Polygoni Multiflori can stop the deposition of cholesterol in liver, the prevention lipid material is in the serum delay or be penetrated into endarterium, and alleviating arteriosclerosis, its contained lecithin is the composition of formation nervous tissue, and can promote the erythrocyte growth promoter.

Herba Ecliptae, cool in nature, liver, kidney channel are returned in sweet in the mouth, acid, have cooling blood for hemostasis, tonifying kidney and nourishing yin, the function of heat-clearing and toxic substances removing is used for the various hemorrhages due to the heat in blood, deficiency of kidney yin, have a dizzy spell, early whitening of beard and hair, go into the kidney nourishing YIN and the hair of growing, women's pudendal pruritus, eczema, paddy-field dermatitis, furuncle and phyma are controlled in external; Toxicity test, to Immune Effects, the Herba Ecliptae decoct is irritated stomach, can obviously increase mouse thymus weight childhood, anastalsis, Herba Ecliptae leaf powder spreads on hemorrhage place of dog tremulous pulse half cut-off and compressing a little outward, and good haemostatic effect is arranged, and water extract also has remarkable anastalsis, its anastalsis and Herba Ecliptae promote blood capillary to shrink, shorten hemorrhage relevantly, in addition bacillus pyocyaneus is had the bacteriostatic effect, obvious sedation and analgesia effect is arranged with blood coagulation.

Cortex Cinnamomi, extremely hot in nature, acrid in the mouth, sweet, return kidney, spleen, heart channel, have insufficiency of kidney-YANG, mend that fire is supporing yang, the function of dispersing cold for relieving pain, warm promoting blood circulation, be used for pain disease due to QI stagnated by cold or the cold blood stasis, the QI and blood deficiency and coldness can be impelled Yin grows while yang is generating and strengthens the effect of invigorating QI and blood; Toxicity test, cinnamic aldehyde can strengthen the guinea pig in vitro myocardial contraction and increase the heartbeat number, can promote SNE to discharge catecholamine, antibacterial action, Oleum Cinnamomi and cinnamic aldehyde have bactericidal action, and be better than feminine gender to the effect of gram positive bacteria, and tangible fungicidal action is also arranged.

Cortex Magnoliae Officinalis: warm in nature, acrid in the mouth, hardship are returned spleen, stomach, large intestine, lung meridian, have relieving distension by promoting circulation of QI, dampness except that full function, are used for the solid cubic content stagnation of QI, the full distension of gastral cavity, dampness-phlegm syndrome, damp-phlegm resistance lung, retention of dampness in middle-JIAO; Toxicity test, the effect of smooth muscle, the Cortex Magnoliae Officinalis decoct all is excitation to rabbit intestine in vitro and bronchus, the Cortex Magnoliae Officinalis decocting liquid can suppress the Skeletal Muscle Contraction that acetylcholine causes, the contained alkaloid of Cortex Magnoliae Officinalis belongs to the muscle relaxant of non-polarized type, antiinflammatory action, the contact dermatitis that the Cortex Magnoliae Officinalis water extract brings out chloropicrin is the strong inhibition effect.

Fructus Psoraleae, warm in nature, acrid in the mouth is returned kidney, spleen channel, has reinforcing the kidney and supporting YANG, helping inspiration to relieve asthma, warm spleen antidiarrheal function, is used for insufficiency of kidney-YANG, failure of the kidney in receiving QI, external curing vitiligo, psoriasis; Toxicity test, to the cardiovascular system effect, the isolated heart test shows, corylifolinin can be expanded Cavia porcellus, rabbit, the arteria coronaria of cat and rat, with Cavia porcellus for, cause photosensitization, psoralen and xanthotoxin cause photosensitization, for oral administration after again with ultraviolet or sun exposure, can make red swelling of the skin, pigment increases, and can be used for curing vitiligo and psoriasis, antibacterial action, staphylococcus aureus there is inhibitory action, the staphylococcus aureus that penicillin and other antibiotic are developed immunity to drugs, Staphylococcus albus etc., Fructus Psoraleae extract can suppress its growth, and mycete is also had certain inhibitory action.

Radix Aconiti Kusnezoffii Preparata has another name called Radix Aconiti, and is hot in nature, and acrid in the mouth is poisonous, and GUIXIN, liver,spleen,kidney warp have dispelling cold and dampness, the ailment said due to cold or exposure of loosing, antalgic, removing mass be by the function of expectorant, is used for arthromyodynia, trusted subordinate's cold type of pain, and external also has an analgesic effect to mucocutaneous; Toxicity test, the anti-mycobacterium tuberculosis effect, injection has certain therapeutical effect to infecting the Bacillus tuberculosis Cavia porcellus, its curative effect is only second to streptomycin and is with dosage and increases progressively relation, the anticoagulant effect has remarkable antithrombase effect, analgesic activity, the water extract is irritated stomach, can prolong the mice hot plate pain reaction time.

Radix Achyranthis Bidentatae, property is flat, and liver, kidney channel are returned in bitter in the mouth, acid, have invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome function, are used for women's amenorrhea, the menoxenia of congestion retardance, and it is dizzy to have a headache, the burning hot disease in tops such as aphtha of the mouth and tongue, soreness of waist and knee joint, weakness of the lower extremities, rheumatic arthralgia; Toxicity test, effect to uterine smooth muscle, the Radix Achyranthis Bidentatae decoct has stronger excitation to unpregnancy and first pregnant mice isolated uterine, the tension force contractility and the rhythm and pace of moving things are all increased, anti-inflammatory and analgesic effect, the mice ear that Radix Achyranthis Bidentatae extract causes Oleum Tiglii has the obvious suppression effect, Radix Achyranthis Bidentatae extract and pure agent PARA FORMALDEHYDE PRILLS(91,95) Da Shu Zu Le swelling also have the obvious suppression effect, protein assimilation, after the mouse peritoneal injection or gavaging ecdysterone or Radix Achyranthis Bidentatae, discovery can obviously improve the function of aminoacid synthetic proteins egg, and action intensity is similar to anabolic hormone, the 4-chlorotestosterone also can promote that the RNA of liver cell nuclear and cell membrane is synthetic simultaneously, promote the mitochondrial albumen of nucleus synthetic, to hemorheological influence, Radix Achyranthis Bidentatae decoct 10 gram/kilograms are irritated stomach, twice of every day.Continuous 3d all has remarkable reduction effect to high low shear rate, whole blood viscosity, erythrocyte proportion, the erythrocyte aggregation index of normal rat.

Radix Paeoniae Alba (parched), cold nature, spleen channel is returned in bitter in the mouth, acid, has to nourish blood and the function of battalion, relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver, is used for menoxenia, shallow complexion, disharmony of nutrient QI with defensive QI, perspiration and aversion to wind, side of body rib, gastral cavity abdomen, the extremity contraction is anxious has a pain; Toxicity test, the cardiovascular system effect, the Radix Paeoniae Alba total glycosides that extracts from the Radix Paeoniae Alba can make the rabbit ear vasodilation of exsomatizing, drip number and capacity increase in the per minute, the Radix Paeoniae Alba hydrotrope has the anti-hypoxia of highly significant, anti-cardiac muscle lacks ischemia and the effect of antiplatelet thrombosis, antibiotic, antiinflammatory action, the Radix Paeoniae Alba is to dysentery bacterium, typhoid fever, Salmonella paratyphi, staphylococcus, bacillus pyocyaneus etc. all have inhibitory action, preserved material has inhibitory action to some pathogenic fungus, the immune system effect, Radix Paeoniae Alba total glucosides is replied mouse immune has regulating action, superpower reaction has potentiation to the mice delayed, the inductive DH of cyclophosphamide is strengthened and suppresses all have obvious antagonism, the Radix Paeoniae Alba to have and obviously protect the liver and reduce the ALT effect.

Pericarpium Citri Reticulatae, warm in nature, bitter in the mouth, suffering are returned spleen, stomach, lung meridian, have the function of circulation of qi promoting spleen invigorating, stomach function regulating preventing or arresting vomiting, drying dampness to eliminate phlegm, are used for stagnation of QI in spleen and stomach, and gastral cavity abdominal distention is vexed, and disorder of stomach-QI, nausea and vomiting, damp-phlegm are stopped up stagnant, cough with copious phlegm; Toxicity test, effect to cardiovascular system, bright Pericarpium Citri tangerinae decoct and alcohol extract, to exsomatizing and excitation all being arranged at the body frog heart, cardiac contractile force is strengthened, output increases, but it is little to the heart rate influence, then be inhibitory action when heavy dose of, antiulcer and digestion-aid effect, the subcutaneous injection Hesperidin has the effect that suppresses the ulcer generation, antibacterial action to experimental gastric ulcer, Pericarpium citri reticuatae chachiensis is in vitro to staphylococcus, mucositis is bacterium how, the growth of hemolytic haemophilus has inhibitory action, in 25% and 50% concentration common superficial mycosis is had inhibitory action, acrothesium floccosum all has inhibitory action, antiinflammatory action, Hesperidin has the effect of vitamin D sample, can reduce capillary permeability, prevent microvascular bleeding, but the antagonism histamine, the vascular permeability that LYSOLECITHIN SUNLECITHIN A causes increases, prevent agkistrodon halyx pallas venom induced mice subcutaneous hemorrhage, hesperidin methyl also has inhibitory action to the permeability of blood capillary.

Folium Mori, cold in nature, bitter in the mouth, sweet is returned lung, Liver Channel, has the function of wind and heat dispersing, cooling blood for improving eyesight, is used for affection due to external wind and heat, fever and headache, pharyngalgia cough, the dizziness headache due to wind-heat of liver channel or liver-fire rise; Toxicity test, Folium Mori have certain hypoglycemic activity, and the Folium Mori injection is very little to the acute toxicity of mice, with 60 times (the each 5 milliliters of intramuscular injection of adult's consumption) of 10% Folium Mori injection people consumption, to mouse peritoneal injection 21d, internal organs there is certain infringement continuously.

Salt, cold in nature, salty in the mouth, return stomach, kidney, large intestine, small intestine meridian, have inducing vomiting, heat clearing away, removing heat from blood, moisturize, detoxifcation, itching relieving function, be used for chronic constipation, dilute salt water is drunk, and the unimpeded effect just of profit is arranged, toothache due to pathogenic wind-heat, gingiva bleeding gingival hemorrhage, the laryngalgia of hyperactivity of deficient fire, carbuncle from the beginning of, enclose medicine with the strong brine accent, skin infection is routed, with the saline cleaning skin ulcer face of 0.9 concentration, can detoxifcation anticorrosion, killing parasites for relieving itching also can be washed skin pruritus, poisonous insect stings.

AES, a kind of special raw material that is used to make abluent, shampoo, shampoo.

Hair cream toxicity test of the present invention, with the white mice is example, the present invention's plaster of having one's hair wash directly is applied on mice baring skin and the fur simultaneously, smear every day once, smeared continuously 15 days, mice fur light, baring skin is normal, there is no unusually, observe, prove absolutely that conjuring cream of the present invention is without any side effects from above white mice test situation.

Hair is divided into epidermal area, cortical layer, medullary substance layer, epidermal area is the ground floor of hair outermost, form by multiwalled overlapping cutin sheet, its outer is towards sending out the tip, the cutin sheet is the translucent and colourless color that can see cortical layer nature pigment particle, it is the outermost layer of hair, accounts for hair 10%; Cortical layer is the second layer of hair, i.e. intermediate layer, and it is a branch of bundle fiber cell, is impregnated with by the pasty mass ring, contains hydrogen bond, also keratin such as amino key, also has the natural pigment particle of hair, cortical layer accounts for 80% of hair; The medullary substance layer is the medullary substance layer at the hair center, is made up of the transparent polygon keratinocyte that is separated from each other, and accounts for hair 10%.

The growth rhythm of hair has trophophase and resting stage, will come off naturally to the certain hour hair, grow new hair, the trophophase of hair is generally 2-6, and be 4-5 month resting stage, the speed of growth of hair is subjected to health effects, faster or slower, the 0.3-0.4 millimeter of growing average every day, the trophophase of hair is the longest in the hair, resting stage is the shortest, general trophophase is 5 years, and the longest 25 years, adult's hair volume is generally about ten thousand of 10-15.

The cause of disease of poliosis can be divided into five kinds:

1, heritability teen-ager leukotrichia mainly is heritability or familial;

2, the aging poliosis is mainly in the old people, and old people's bodily tissue organ is in aging, and kidney qi is not prosperous, and QI and blood is not prosperous, and the decline of pigment embryo blast cell stops the generation of pigment particle in sending out, so hair bleaches, generally betides more than 50 years old;

3, chemical poliosis mainly is the bleached chemical effect of peroxide and ammonia, dyes effect with color.

4, symptomatic poliosis is also pretended illness because of the property poliosis, and its origin cause of formation is many-sided, mainly comprises malnutrition, QI and blood wanes, the B that is deficient in vitamin, acute and chronic infectious disease and wasting diseases, strong direct stimulation, the emotion wound, troubled thoughts are excessive and work with one's mind excessively aspects such as cardiovascular disease and hypertension;

5, anaphylaxis poliosis, hypersensitive test is not made in the dyeing operation error, and coup injury epidermal area hair, middle level hair cause deep layer root of hair hair follicle to be poisoned, and make the on the high side of alopecia, also have hair color to bleach.

Alopecia mainly is divided into: naturality alopecia, alopecia areata are alopecia after circular alopecia (being commonly called as alopecia areata), seborrheic alopecia, the suckling, the alopecia (Secondary cases alopecia) of strain property, alopecia cicatrisata, aging alopecia.

Four, specific embodiments

Below in conjunction with embodiment the present invention is described in further detail.

Embodiment 1, takes by weighing 2 parts of Radix Sophorae Flavescentiss, 2.5 parts of the Radixs Angelicae Dahuricae, 2 parts of Fructus Arctiis, 1 part of Radix Saposhnikoviae, 0.2 part of Rhizoma Typhonii, 2 parts of the Fructus Kochiae, 2 parts of Fructus Ligustri Lucidi, 0.8 part of Radix Angelicae Sinensis, 1 part of Radix Dipsaci, 0.8 part of Rhizoma Ligustici, 2 parts of Radix Polygoni Multiflori, 2 parts of Herba Ecliptaes, 1 part of Cortex Cinnamomi, 1 part of Cortex Magnoliae Officinalis, 0.8 part of Fructus Psoraleae, 0.8 part of Radix Aconiti Kusnezoffii, 2 parts of Radix Achyranthis Bidentataes, 0.9 part of Radix Paeoniae Alba (parched), 0.8 part on Folium Mori, 0.9 part of Pericarpium Citri Reticulatae, 5 parts of salt, AES5 part, 50 parts in water, outside the medicine desalination and AES that weigh up, other medicines are positioned over soaks 1-2 hour in the container, with slow fire that water is boiled then, open the back after 15-20 minute, medicine soup is filtered out, be positioned in another container, decoct repeatedly three times, after the medicine soup mixing with three acquisitions, filter with the 80-100 mesh filter screen, obtain filtrate, filtrate is precipitated 1-2 hour after, disgorging, twice sedimentation and filtration obtains filtrate repeatedly, filtrate is added AES, stir, until no AES piece to a direction, the filtrate cold adds salt during to room temperature, stirs into even paste to a direction and gets final product.

Embodiment 2, take by weighing 7 parts of Radix Sophorae Flavescentiss, 9 parts of the Radixs Angelicae Dahuricae, 7 parts of Fructus Arctiis, 4 parts of Radix Saposhnikoviaes, 7 parts of Rhizoma Typhoniis, 8 parts of the Fructus Kochiae, 8 parts of Fructus Ligustri Lucidi, 7 parts of Radix Angelicae Sinensis, 4 parts of Radix Dipsacis, 3 parts of Rhizoma Ligusticis, 9 parts of Radix Polygoni Multiflori, 8 parts of Herba Ecliptaes, 4 parts of Cortex Cinnamomis, 4 parts of Cortex Magnoliae Officinalis, 6 parts of Fructus Psoraleaes, 3 parts of Radix Aconiti Kusnezoffii, 7 parts of Radix Achyranthis Bidentataes, 7 parts of Radix Paeoniae Alba (parched)s, 6 parts on Folium Mori, 7 parts of Pericarpium Citri Reticulataes, 12 parts of salt, AES12 part, 300 parts in water, preparation method is with embodiment 1.

Embodiment 3, take by weighing 4.5 parts of Radix Sophorae Flavescentiss, 6 parts of the Radixs Angelicae Dahuricae, 4.5 parts of Fructus Arctiis, 2.5 parts of Radix Saposhnikoviaes, 3 parts of Rhizoma Typhoniis, 5 parts of the Fructus Kochiae, 5 parts of Fructus Ligustri Lucidi, 3 parts of Radix Angelicae Sinensis, 2.5 parts of Radix Dipsacis, 2 parts of Rhizoma Ligusticis, 5.5 parts of Radix Polygoni Multiflori, 5 parts of Herba Ecliptaes, 2.5 parts of Cortex Cinnamomis, 2.5 parts of Cortex Magnoliae Officinalis, 3.4 parts of Fructus Psoraleaes, 1.9 parts of Radix Aconiti Kusnezoffii, 4.5 parts of Radix Achyranthis Bidentataes, 3.5 parts of Radix Paeoniae Alba (parched)s, 3.4 parts on Folium Mori, 3.6 parts of Pericarpium Citri Reticulataes, 8 parts of salt, AES9 part, 200 parts in water, preparation method is with embodiment 1.

When using hair cream of the present invention, do not mix use with other products.

1, hair washing method commonly used: hair is soaked, and it is soft at head to get an amount of hair cream, and water rinses, and gets an amount of hair cream again and gently rubs at root of hair, gently rub 3-10 minute after, kept 10-40 minute, rinse and get final product.

2, treatment hair washing method: first day wash clean hair, second day dawn sent out, and spread hair cream after having pulled out and gently rubbed, and need not wash, and kept hair cream on scalp, allowed scalp fully absorb the drug, and kept more than 20 minutes.

Points for attention:

1, before use this product, poliosis must be pulled up, be beneficial to root of hair and absorb;

2, might produce the dandruff in the use, this is because the reason of toxin expelling is a normal phenomenon:

Be not splashed in the eyes when 3, using,, use a large amount of flushing with clean water as early as possible if be splashed into;

4, please this product being positioned over shady and cool place preserves;

5, make sure to keep in mind to have hair dyed, perm during the treatment;

6, this product is invalid to alopecia totalis, heritability alopecia poliosis, 60 years old the above persons.

Clinical data

The 86 routine alopecia areata patients sequence number of going to a doctor is divided into two groups at random, treats 46 examples, contrast 40 examples.

1.1 two groups of GCSs relatively see Table 1, analyze P＞0.05, no significant difference through Ridit.

The clinical physical data of table 1 relatively

Sex age course of disease site of pathological change

The n men and women 5-25 26-60 1-3 month is end-to-end two rear flank hardwood portions more than 3 years

Treatment organizes 46 32 14 10 36 40 63 36 7

Matched group 40 28 12 9 31 35 53 31 6

1.2 diagnosis basis

(1) past does not have the alopecia areata history, local becomes the defluxion medical history, or alopecia unconsciously, but hair do not fall in flakes, becomes the rare medical history of hair;

(2) local bright and clean, level and smooth, NIP, abscess, cicatrix, depression, the alopecia areata border is clearly demarcated;

(3) seborrheic alopecia, volume top hypotrichosis jewelry, expensive clothing and other valuables, often with capitis pityriasis, hair is glossy, and the bran bits are many, conscious pruritus.

2, Therapeutic Method

2.1 medicine is formed: medicine of the present invention;

2.2 manufacture method: manufacture method of the present invention;

2.3 administrated method:

(1) treatment group: by aforementioned using method of the present invention;

(2) matched group: the doctor trained in Western medicine expectant treatment, 101 HAIR REGENERATING MEDICINE is smeared at oral Alopecia Pill or alopecia areata position.

3, observation of curative effect

3.1 criterion of therapeutical effect

Recovery from illness: alopecia areata position hair begins growth;

Invalid: treat only general doing well,improving after 3 months, alopecia areata position hair is growth not.

3.2 therapeutic effect sees Table 2, by 6 months treatment, two groups of curative effects were analyzed p＜0.05 through Ridit, and there were significant differences.

Table 2 liang group curative effect relatively

N cures the average natural law of invalid total effective rate cured person that takes a turn for the better

Treatment organizes 46 32 10 4 91% 92

Matched group 40 20 7 13 68% 162

Treatment poliosis, toxin expelling do not contrast scheme at present, and curative effect situation of the present invention is as follows: the present invention treats poliosis case 36 examples, effective percentage 98%, treatment toxin expelling case 42 examples, effective percentage 99%.

4, medical record for example

Liu so-and-so, woman, 42 years old, Laizhou City people from Pinglidian, first visit in Augusts 15 in 1999 is because of the alopecia of sudden head large tracts of land, form alopecia areata, half a year many, do not take effect through multi-treatment, be suitable for hair cream of the present invention, used 4 months continuously, the alopecia areata position is born soft fine, uses continuously 7th month, the alopecia areata position begins to grow common hair color, and symptom disappears substantially.

Fight certain, man, 31 years old, people from Laizhou City, JIUYUE in 2000 first visit on the 23rd, because of the hair poliosis was more in recent years, the history of having hair dyed simultaneously is longer, causes capitis pityriasis, scalp is more, through adopting conventional therapy, though the dandruff reduces, but the curative effect instability has repeatedly, poliosis symptom no change, use the present invention after 5 months, the dandruff disappears substantially, and poliosis obviously reduces, used 10 months continuously, the symptom complete obiteration, poliosis does not have substantially.

Claims (3)

1, a kind of hair cream for the treatment of the hoariness and alopecia toxin expelling is characterized in that being made up of following weight portion medicine: Radix Sophorae Flavescentis 2-7 part, Radix Angelicae Dahuricae 2.5-9 part, Fructus Arctii 2-7 part, Radix Saposhnikoviae 1-4 part, Rhizoma Typhonii 0.2-7 part, Fructus Kochiae 2-8 part, Fructus Ligustri Lucidi 2-8 part, Radix Angelicae Sinensis 0.8-7 part, Radix Dipsaci 1-4 part, Rhizoma Ligustici 0.8-3 part, Radix Polygoni Multiflori 2-9 part, Herba Ecliptae 2-8 part, Cortex Cinnamomi 1-4 part, Cortex Magnoliae Officinalis 1-4 part, Fructus Psoraleae 0.8-6 part, Radix Aconiti Kusnezoffii 0.8-3 part, Radix Achyranthis Bidentatae 2-7 part, Radix Paeoniae Alba (parched) 0.9-7 part, Folium Mori 0.8-6 part, Pericarpium Citri Reticulatae 0.9-7 part, salt 5-12 part, AES5-12 part, water 50-300 part.

2, a kind of method for preparing the hair cream of the described treatment hoariness and alopecia of claim 1 toxin expelling is characterized in that this method may further comprise the steps:

A, to take by weighing required medicine standby;

B, with outside the medicine desalination and AES that weigh up, other medicines are positioned over soaks 1-2 hour in the container;

C, water is boiled with slow fire opened the back after 15-20 minute, and medicine soup is filtered out, and was positioned in another container;

D, step c three times repeatedly;

After e, the medicine soup mixing, filter, obtain filtrate with the 80-100 mesh filter screen with three acquisitions;

F, filtrate precipitated 1-2 hour after, disgorging;

G, twice sedimentation and filtration repeatedly obtain filtrate;

H, filtrate is added AES, stir to a direction, until no AES piece;

I, filtrate cold add salt during to room temperature, stir into even paste to a direction and get final product.

3, a kind of method for preparing the hair cream of treatment hoariness and alopecia toxin expelling according to claim 2 is characterized in that container used among the step b can be aluminum matter, rustless steel or container made of iron.