CN102451126A - Hair-growing cosmetic composition, and preparation method thereof - Google Patents
Hair-growing cosmetic composition, and preparation method thereof Download PDFInfo
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- CN102451126A CN102451126A CN2010105223421A CN201010522342A CN102451126A CN 102451126 A CN102451126 A CN 102451126A CN 2010105223421 A CN2010105223421 A CN 2010105223421A CN 201010522342 A CN201010522342 A CN 201010522342A CN 102451126 A CN102451126 A CN 102451126A
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Abstract
The invention discloses a hair-growing cosmetic composition. An extraction solution containing the hair-growing cosmetic composition can be obtained by extracting plant which comprises acorus gramineus, spirulina powder, vitamin B5 and at least one of Chinese herbal medicines by using a small amount of an organic solution, and then performing solid-liquid separation and pelletizing. By a preparation method for the hair-growing cosmetic composition, the process can effectively simplified and the using of organic solvent can be reduced, and the obtained hair-growing cosmetic composition can promote hair to be blackened and grown and capillus to be increased, and the thick flavor of the Chinese herbal medicines can be saved or reduced greatly.
Description
Technical field
The invention relates to a kind of vegetalization cosmetic compositions and manufacturing approach thereof, particularly send out cosmetic composition and manufacturing approach thereof relevant for a kind of educating.
Background technology
The Chinese herbal medicine extract is widely used in natural drug (phyto-medicine), replenishes in alternative medicine therapy (alternative medicine), dietary supplement (dietary supplement), the function cosmetics (cosmaceuticals).The Chinese herbal medicine application mode, also by traditional directly take, coating, decoction, the red ball of cream are loose etc., along with the progress of science and technology, utilize different extraction modes, can further define and understand the contained active ingredient of Chinese herbal medicine.
Chinese herbal medicine extraction mode can generally be divided into the extraction of liquid phase-liquid phase or the extraction of solid phase-liquid phase, and wherein the extraction of solid phase-liquid phase also is called " leaching ", is the composition that utilizes in all kinds of solvents separating solids mixture.
The Chinese herbal medicine extract can be according to different purpose or demand, and utilizes different modes to extract.General for example steam distillation method capable of using, fat are inhaled (oils and fats separation) method, solvent extraction, cold press method, supercritical fluid carbon dioxide extraction, deep fat infusion method, resin extraction, vacuum distillation method etc., the different components of extraction Chinese herbal medicine.
Though Chinese herbal medicine contains many active ingredients, the flavour of a drug of Chinese herbal medicine are thick and heavy, educate when sending out product being applied to, and its thick and heavy taste of Chinese medicine is not easy to be accepted by most of people.Secondly, when using convention extraction Chinese herbal medicine, can consume a large amount of water or organic solvent, treatment step is also comparatively loaded down with trivial details simultaneously.
In view of this, needing badly provides a kind of educating to send out a cosmetic composition and a manufacturing approach thereof, overcoming the thick and heavy problem of taste of Chinese medicine, and reduces the consumption of water or organic solvent.
Summary of the invention
An embodiment of the present invention is that a kind of manufacturing approach of sending out cosmetic composition of educating is being provided; It utilizes a small amount of organic extractant solution one vegetable matter; Wherein this vegetable matter can comprise for example Rhizoma Acori Graminei (Acorus gramineus), spirulina (Spirulina sp.) powder, vitamin B5 and at least one Chinese medicinal herbs; It can obtain to contain the extract of educating a cosmetic composition after solid-liquid filtration and micronize processing.This educates the use that manufacturing approach of sending out cosmetic composition can effectively be simplified processing procedure and reduce organic solvent, and gained educate send out a cosmetic composition can promote color development increase black, capillus increases, hair is grown up does not have again or significantly reduce thick and heavy taste of Chinese medicine.
Secondly; Another embodiment of the present invention is to provide a kind of educating to send out cosmetic composition; It is to utilize said method extraction vegetable matter and get, can promote color development increase black, capillus increases, hair is grown up and do not have or significantly reduce thick and heavy taste of Chinese medicine, can use being added into a relevant product of educating.
According to above-mentioned embodiment of the present invention, propose a kind of Chinese herbal medicine and educate the manufacturing approach of sending out cosmetic composition.In one embodiment, at first carry out an extraction step, it ties up in the reactive tank, with 0 ℃ to 50 ℃ temperature, utilizes an organic extractant solution one vegetable matter 2 hours to 72 hours.
In the above-described embodiments, aforesaid reactive tank for example can be an agitator tank, and this agitator tank system is with for example 20 to 50 ℃ temperature, by aforesaid organic extractant solution vegetable matter 2 hours to 72 hours.
In other embodiments, the previous reaction groove for example can be a Supersonic wave trough, and the frequency of this Supersonic wave trough for example 30kHz to 70kHz capable of using, by aforesaid organic extractant solution vegetable matter 2 hours to 4 hours.In this embodiment, aforesaid Supersonic wave trough more can have a circulating cooling system, makes the temperature maintenance of this Supersonic wave trough when carrying out extraction step at for example 0 ℃ to 30 ℃.
When carrying out extraction step, the w/v of aforesaid vegetable matter and organic solution for example can be 0.1g/mL to 0.3g/mL.In another illustration, aforesaid organic solution for example can be 1: 4 to 3: 2 ethanol of volume ratio and water.In another illustration, aforesaid vegetable matter can comprise the Rhizoma Acori Graminei (Acorus gramineus) of 2 percentage by weight to 4 percentage by weights, spirulina (Spirulina sp.) powder of 3 percentage by weight to 5 percentage by weights, the vitamin B5 of 0.5 percentage by weight to 2 percentage by weight and at least one Chinese medicinal herbs of 89 percentage by weight to 94.5 percentage by weights.In another illustration again, aforesaid at least one Chinese medicinal herbs can include but not limited to the group that Semen Ginkgo (Ginkgo biloba) leaf, Semen Cuscutae (Cuscuta australis R.Brown or Cucsuta obtusiflora Kunth var.australis Engelm.), Radix Angelicae Sinensis (Angelicae Sinensis Radix), Cortex Moutan (root cortex of Paenoina suffruticos), Radix Rehmanniae Preparata (Rehmanniae Preparata Radix), Fructus Psoraleae (Psoraleae semen), Radix Polygoni Multiflori (Polygonum multiflorun, Dioscoreabulbifera or Cynanchum wilfordi), the Radix Paeoniae Alba (Paeonia lactiflora), Rhizoma Polygonati (rhizome of Polygonatum kingianum Coll.Ex Hemsl., Polygonatumsibiricum Red. or Polygonatum cyrtonema Hua), Fructus Schisandrae Chinensis (SchisandraeFructus), Cortex Lycii (Lycii Radicis Cortex), Radix Ginseng (Ginseng Radix), Fructus Corni (Cornus officinalis), Rhizoma Zingiberis Recens (Zingiberis Rhizoma), Fructus Ligustri Lucidi (Ligustrum Lucidum), Cortex Cinnamomi (Cinnamomi Cortex), Semen Sesami Nigrum (5esamunindicium Linn.), Radix Salviae Miltiorrhizae (Salvia multiorrhizae Bunge), Cacumen Platycladi (Platycladus orientalis (L.) Franco) leaf, Rhizoma Chuanxiong (LigusticumRhizoma), Rhizoma Drynariae (Drynariae Rhizoma), Radix Astragali (Astragali Radix), Fructus Mori (Mori Fructus), Fructus Rubi (Rubi Fructus), Radix Polygalae (Polygalae Radix), Semen sojae atricolor (Glyeine max (L.) Merrill), Radix Aconiti Lateralis Preparata (Radix aconiti lateralispreparata) or above-mentioned combination in any are formed.
Then, carry out solid-liquid separation step, to obtain a filtrating by the aforementioned organic solution that contains vegetable matter.
Then, carry out the micronize step, to obtain an extract by aforementioned filtrating.In an illustration, methods such as for example ball mill pulverizing method capable of using, pneumatic type injection comminuting method or high pressure homogenizing are carried out, with the above-mentioned filtrating of micronize.In another illustration, through micronize and the median particle diameter (D50) of extract for example can be 500nm to 1000nm, wherein this extract can comprise that aforesaid educating send out a cosmetic composition, and educating of gained sent out a cosmetic composition and do not had or significantly reduce taste of Chinese medicine.
In an embodiment of the present invention, when carrying out aforementioned extraction step, more can add bittern water in the aforementioned organic solution that contains vegetable matter.
According to other embodiment of the present invention, propose a kind of educating and send out cosmetic composition, it is characterized in that this and educate a cosmetic combinations system and utilize above-mentioned arbitrary method obtained.
Use of the present invention educating and send out cosmetic composition and manufacturing approach thereof; It is to utilize a small amount of organic extractant solution one vegetable matter; Wherein this vegetable matter can comprise for example Rhizoma Acori Graminei, Spirulina powder, vitamin B5 and at least one Chinese medicinal herbs; After solid-liquid separation and micronize processing, can obtain to contain the extract of educating a cosmetic composition again.This Chinese herbal medicine is educated the use that the manufacturing approach of sending out cosmetic composition can effectively be simplified processing procedure and reduce organic solvent, and the Chinese herbal medicine of gained educate send out a cosmetic composition can promote color development increase black, capillus increases, hair is grown up does not have again or significantly reduce thick and heavy taste of Chinese medicine.
Description of drawings
For letting above and other objects of the present invention, characteristic, advantage and the embodiment can be more obviously understandable, appended graphic detailed description be following:
Educate the manufacturing flow chart of sending out cosmetic composition shown in Fig. 1 according to an embodiment of the invention.
Fig. 2 educates the HPLC comparison collection of illustrative plates of sending out cosmetic composition according to an embodiment of the invention for showing.
Fig. 3 shows the HPLC comparison collection of illustrative plates of educating each composition part of sending out cosmetic composition according to an embodiment of the invention.
Fig. 4 illustrates to educate the HPLC comparison collection of illustrative plates of sending out cosmetic composition according to another embodiment of the present invention.
[primary clustering symbol description]
100: method
103: carry out solid-liquid separation step, to obtain the step of filtrating by the organic solution that contains vegetable matter
105: the above-mentioned filtrating of micronize, to obtain extract by filtrating, wherein extract can comprise the step of educating a cosmetic composition
101: extract processing procedure, to utilize the step of organic extractant solution vegetable matter
201/203/205/301/303/305/
307/309/311/313/315/317
/319/321/323/325/327/329/
331/333/335/337/339/341/
343/345/347/349/351/353/
355/357/401/403: curve
The specific embodiment
Brought forward is said, and the present invention provides a kind of Chinese herbal medicine to educate and sends out cosmetic composition and manufacturing approach thereof, and it is to utilize a small amount of organic extractant solution one vegetable matter.
Alleged here " educate and send out cosmetic composition " of the present invention means that the source is main with vegetable matters such as Chinese medicinal herbses; Contain to educate through the extract that extraction, solid-liquid filter and micronize is handled gained and send out a cosmetic composition, can promote color development to increase black, capillus increase, hair growth etc. and educate hair.
In one embodiment, this vegetable matter can comprise for example Rhizoma Acori Graminei (Acorusgramineus), spirulina (Spirulina sp.) powder, vitamin B5 and at least one Chinese medicinal herbs.In an illustration, aforesaid vegetable matter can comprise the Rhizoma Acori Graminei of 2 percentage by weight to 4 percentage by weights, the Spirulina powder of 3 percentage by weight to 5 percentage by weights, the vitamin B5 of 0.5 percentage by weight to 2 percentage by weight and at least one Chinese medicinal herbs of 89 percentage by weight to 94.5 percentage by weights.In another illustration, aforesaid Chinese medicinal herbs can include but not limited to the group that Semen Ginkgo (Ginkgo biloba) leaf, Semen Cuscutae (Cuscuta australis R.Brown or Cucsutaobtusiflora Kunth var.australis Engelm.), Radix Angelicae Sinensis (AngelicaeSinensis Radix), Cortex Moutan (root cortex of Paenoina suffruticos), Radix Rehmanniae Preparata (Rehmanniae Preparata Radix), Fructus Psoraleae (Psoraleae semen), Radix Polygoni Multiflori (Polygonum multiflorun, Dioscorea bulbifera or Cynanchumwilfordi), the Radix Paeoniae Alba (Paeonia lactiflora), Rhizoma Polygonati (rhizome of Polygonatumkingianum Coll.Ex Hemsl., Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua), Fructus Schisandrae Chinensis (Schisandrae Fructus), Cortex Lycii (Lycii Radicis Cortex), Radix Ginseng (Ginseng Radix), Fructus Corni (Cornusofficinalis), Rhizoma Zingiberis Recens (Zingiberis Rhizoma), Fructus Ligustri Lucidi (LigustrumLucidum), Cortex Cinnamomi (Cinnamomi Cortex), Semen Sesami Nigrum (Sesamun indicium Linn.), Radix Salviae Miltiorrhizae (Salvia multiorrhizae Bunge), Cacumen Platycladi (Platycladus orientalis (L.) Franco) leaf, Rhizoma Chuanxiong (Ligusticum Rhizoma), Rhizoma Drynariae (DrynariaeRhizoma), Radix Astragali (Astragali Radix), Fructus Mori (Mori Fructus), Fructus Rubi (RubiFructus), Radix Polygalae (Polygalae Radix), Semen sojae atricolor (Glycine max (L.) Merrill), Radix Aconiti Lateralis Preparata (Radix aconiti lateralis preparata) or above-mentioned combination in any are formed.
In addition; Alleged here " Spirulina powder " of the present invention can comprise and utilize any type of frond of conventional process gained or algae powder, for example fresh frond, through exsiccant frond, cryodesiccated frond, above-mentioned through the algae powder that grinds or any type of frond or the algae powder of other convention.
Of the present invention educating sent out the above-mentioned vegetable matter of a small amount of organic extractant solution of cosmetic combinations system utilization and got.See also Fig. 1, it is to illustrate to educate the manufacturing flow chart of sending out cosmetic composition according to an embodiment of the invention.And then say it, in one embodiment, this educates the manufacturing approach 100 of sending out cosmetic composition can carry out an extraction step earlier; It ties up in the reactive tank; With about 0 ℃ to about 50 ℃ temperature, utilize an organic extractant solution one vegetable matter 2 hours to 72 hours, shown in step 101.In an illustration, the w/v of aforesaid vegetable matter and organic solution for example can be 0.1g/mL to 0.3g/mL.In another illustration, aforesaid organic solution for example can be 1: 4 to 3: 2 ethanol of volume ratio and water.In another illustration, aforesaid organic solution for example can be 1: 1 ethanol of volume ratio and water.In another illustration again, aforesaid ethanol can include but not limited to the ethanol (the for example medicinal alcohol of 95% (v/v)) or the Radix Betae ethanol (beet alcohol) of dehydrated alcohol, 95 percents by volume.In another illustration again, when carrying out aforementioned extraction step, more can add bittern water in the aforementioned organic solution that contains vegetable matter.
In the above-described embodiments, aforesaid reactive tank for example can be an agitator tank, in for example about 20 to about 50 ℃ temperature, by aforesaid organic extractant solution (following also can be described as leaching) vegetable matter 2 hours to 72 hours.In other embodiments, the previous reaction groove for example can be a Supersonic wave trough, and the frequency of this Supersonic wave trough for example 30kHz to 70kHz capable of using, leaches vegetable matter 2 hours to 4 hours by aforesaid organic solution.In this embodiment; Aforesaid Supersonic wave trough more can have a circulating cooling system; Make the temperature maintenance of this Supersonic wave trough when carrying out extraction step at for example about 0 ℃ to about 30 ℃; The heat loss that is produced when reducing because of the operation ultrasound, and can avoid the volatilization of low-boiling point material and the inactivation of bioactive substance.
Then, carry out solid-liquid separation step, to obtain a filtrating by the aforementioned organic solution that contains vegetable matter; Wherein this filtrating can comprise an aforesaid cosmetic composition of educating; Shown in step 103, drive the method for capable solid-liquid separation in the thought into, the filter membrane of for example convention capable of using (filter material), diatomite filtration method, mode such as centrifugal are carried out; Those skilled in the art knew under this should be the present invention, so do not give unnecessary details in addition.
Then, the above-mentioned filtrating of micronize is shown in step 105, to obtain an extract by aforementioned filtrating.In an illustration, method such as for example ball milling or high pressure homogenizing etc. capable of using, the above-mentioned filtrating of micronize.In another illustration, through micronize and the median particle diameter (D50) of extract for example can be 500nm to 1000nm.
What deserves to be mentioned is; Utilize aforementioned vegetable matter with special formulation; After a small amount of organic extractant solution and micronize processing; Not only effectively simplify processing procedure and reduce the use of organic solvent, can effectively remove again or significantly reduce and educate the thick and heavy taste of Chinese medicine of sending out cosmetic composition, so can be applicable to a relevant product of educating.For example, the extract of above-mentioned gained can be separately sent out a product as educating, and perhaps extract is added directly to existing educating and sends out in the product as active component, or extract is added into existing educating again after drying sends out in the product as active component.
Alleged here " educate send out a product " of the present invention mean add above-mentioned educate send out cosmetic composition as active component after, can separately or make an addition to other convention and educate and send out in the product, with promote color development increase black, capillus increases, the hair growth.Of the present invention educating sent out cosmetic composition after trial volunteer uses 6 months to 12 months, prove to have to promote color development to increase function black, that capillus increases, hair is grown up, and nothing or significantly reduce thick and heavy taste of Chinese medicine.
Below utilize several embodiments so that application of the present invention to be described, so it is not that those skilled in the art under the present invention are not breaking away from the spirit and scope of the present invention, when doing various changes and retouching in order to qualification the present invention.
Embodiment one: preparation Chinese herbal medicine hair-growing composition
Cosmetic composition is sent out relevant for utilizing the vegetable matter preparation to educate by this embodiment system.The vegetable matter system that this embodiment uses comprises the Rhizoma Acori Graminei of 2 percentage by weight to 4 percentage by weights, the Spirulina powder of 3 percentage by weight to 5 percentage by weights, the vitamin B5 of 0.5 percentage by weight to 2 percentage by weight and at least one Chinese medicinal herbs of 89 percentage by weight to 94.5 percentage by weights.Aforesaid at least one Chinese medicinal herbs can include but not limited to the group that Folium Ginkgo, Semen Cuscutae, Radix Angelicae Sinensis, Cortex Moutan, Radix Rehmanniae Preparata, Fructus Psoraleae, Radix Polygoni Multiflori, the Radix Paeoniae Alba, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Cortex Lycii, Radix Ginseng, Fructus Corni, Rhizoma Zingiberis Recens, Fructus Ligustri Lucidi, Cortex Cinnamomi, Semen Sesami Nigrum, Radix Salviae Miltiorrhizae, Cacumen Platycladi, Rhizoma Chuanxiong, Rhizoma Drynariae, Radix Astragali, Fructus Mori, Fructus Rubi, Radix Polygalae, Semen sojae atricolor, Radix Aconiti Lateralis Preparata or above-mentioned combination in any are formed.In another illustration, shown in aforesaid vegetable matter the 1st table:
The 1st table
Then, the vegetable matter of the 1st table is placed agitator tank, mixing plant (auspicious Thailand smart machine limited company, HD-550, Taiwan) for example is in for example about 20 to about 50 ℃ temperature, change (revolution per minute with per minute about 2000; Rpm) to the rotating speed of about 3000rpm; By ethanol water (the for example ethanol and the water of 1: 1 95 percents by volume of volume ratio; Ultimate density is the ethanol water of 47.5 percents by volume) extracted vegetable matter 2 hours to 72 hours, wherein the vegetable matter of the 1st table and the w/v of ethanol water for example can be 0.1g/mL to 0.3g/mL.Perhaps, the vegetable matter of the 1st table is placed above-mentioned agitator tank,, extracted vegetable matter about 2 hours to 4 hours by aforesaid ethanol water in for example about 45 ℃ temperature, the rotating speed of about 2500rpm.
Another kind of mode; Also can with the 1st the table vegetable matter place the Supersonic wave trough, for example the ultrasound disintegrating apparatus (SONIC, VCX 750; U.S.A.); With the frequency of for example 30kHz to 70kHz, in for example about 0 ℃ to about 30 ℃ temperature, by Radix Betae ethanol water (volume ratio 1: 1 Radix Betae ethanol and water for example; Ultimate density is the Radix Betae ethanol water of 50 percents by volume) extracted vegetable matter 2 hours to 72 hours, wherein the vegetable matter of the 1st table and the w/v of Radix Betae ethanol water for example can be 0.1g/mL to 0.3g/mL.Perhaps; The vegetable matter of the 1st table is placed above-mentioned Supersonic wave trough; In for example about 45 ℃ temperature; Extracted vegetable matter about 2 hours to 4 hours by aforesaid ethanol water, wherein the vegetable matter of the 1st table and the w/v of ethanol water for example can be 0.1g/mL to 0.3g/mL.After this extraction step was handled, its solid content for example can be 1 percentage by weight to 5 percentage by weight.
In another embodiment, when carrying out aforementioned extraction step, more can add bittern water in the aforementioned organic solution that contains vegetable matter.Alleged here " the bittern water " of the present invention means that utilizing brine gauge to record Baume degrees (° B é) reaches the salt that 29 degree are above, have bitterness.In an illustration, this bittern water for example can be 0.2% (m/m) to 0.5% (m/m) in the aforementioned addition that contains the organic solution of vegetable matter.In another illustration, this bittern water for example can be 0.3% (m/m) to 0.4% (m/m) in the aforementioned addition that contains the organic solution of vegetable matter.
Then, for example filter membrane capable of using (filter material), diatomite filtration method, conventional approaches such as centrifugal are carried out solid-liquid separation step and are obtained a filtrating.
Afterwards, carry out the micronize processing procedure, to obtain an extract by aforementioned filtrating.It can be to utilize ball mill pulverizing equipment, pneumatic type to spray disintegrating apparatus or high pressure homogenizing equipment, makes the further micronize of above-mentioned filtrating.Another kind of mode, (APV-2000high pressure homogenizer for example, SPX Corp. U.S.A), makes the further micronize of above-mentioned filtrating to high pressure homogenizing equipment also capable of using.Through micronize and the median particle diameter (D50) of extract for example can be 500nm to 1000nm, wherein this extract can comprise that aforesaid educating send out a cosmetic composition, and this educates and sends out a cosmetic composition and do not have or significantly reduce thick and heavy taste of Chinese medicine.In utilizing the embodiment of Radix Betae ethanol water extraction, its typical mean solids content is about 3.39%, and measures and contain the polyphenol of the zingiberol of the 0.084mg/mL that has an appointment, about 1.57mg/mL and total candy of about 46mg/mL.
Be noted that because this embodiment utilizes the 1st table to have the vegetable matter of special formulation at this, handle, therefore can effectively remove or significantly reduce and educate the thick and heavy taste of Chinese medicine of sending out cosmetic composition through a small amount of organic extractant solution and micronize.
See also Fig. 2, it is cosmetic composition is sent out in demonstration according to an embodiment of the invention through educating of agitator tank gained high efficiency LC (High Performance LiquidChromatography; HPLC) comparison collection of illustrative plates, wherein transverse axis be the time (minute), the longitudinal axis is trap (absorbance unit; A.U.); Curve 201 is the HPLC analysis result of Cacumen Platycladi; Curve 203 is the HPLC analysis result of educating a cosmetic composition that utilizes vegetable matter (the not containing Cacumen Platycladi) gained of the 1st table, and curve 205 is the HPLC analysis result of educating a cosmetic composition that utilizes the vegetable matter gained of the 1st table.
See also Fig. 3, it is that the HPLC comparison collection of illustrative plates that each that send out cosmetic composition formed part is educated in demonstration according to an embodiment of the invention, wherein transverse axis be the time (minute), the longitudinal axis is trap (absorbance unit; A.U.), to show curve 301 (spirulina), curve 303 (Cortex Lycii), curve 305 (Radix Aconiti Lateralis Preparata), curve 307 (Radix Rehmanniae Preparata), curve 309 (Radix Astragali), curve 311 (Rhizoma Polygonati), curve 313 (Semen sojae atricolor), curve 315 (Fructus Corni), curve 317 (Fructus Ligustri Lucidi), curve 319 (Radix Ginseng), curve 321 (Rhizoma Zingiberis Recens), curve 323 (Fructus Rubi), curve 325 (Fructus Mori), curve 327 (Semen Sesami Nigrum), curve 329 (Fructus Psoraleaes; Psoralea corylifolia L.), the HPLC analysis result of curve 331 (Rhizoma Drynariae), curve 333 (Semen Cuscutae), curve 335 (Radix Polygalae), curve 337 (Rhizoma Acori Graminei), curve 339 (Rhizoma Chuanxiong), curve 341 (Radix Polygoni Multiflori), curve 343 (Radix Angelicae Sinensis), curve 345 (Cortex Cinnamomi), curve 347 (Fructus Schisandrae Chinensis), curve 349 (Radix Paeoniae Alba), curve 351 (Radix Salviae Miltiorrhizae), curve 353 (Cortex Moutan), curve 355 (Folium Ginkgo), curve 357 (educate and send out cosmetic composition).
Comparison by Fig. 2 and Fig. 3 can be known; Each composition that cosmetic composition contains the listed vegetable matter of the 1st table is really sent out in educating of embodiment one gained, comprises spirulina, Cortex Lycii, Radix Aconiti Lateralis Preparata, Radix Rehmanniae Preparata, Radix Astragali, Rhizoma Polygonati, Semen sojae atricolor, Fructus Corni, Fructus Ligustri Lucidi, Radix Ginseng, Rhizoma Zingiberis Recens, Fructus Rubi, Fructus Mori, Semen Sesami Nigrum, Fructus Psoraleae, Rhizoma Drynariae, Semen Cuscutae, Radix Polygalae, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Radix Polygoni Multiflori, Cacumen Platycladi, Radix Angelicae Sinensis, Cortex Cinnamomi, Fructus Schisandrae Chinensis, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Cortex Moutan, Folium Ginkgo.
In this embodiment, HPLC more capable of using system, for example diode arrays UV detector (Diode Array UV Detector, HITACHI, L-7455, Tokyo, Japan).The chromatography condition illustration is following: the chromatography tubing string for example can be COSMOSIL 5C18 MS-II tubing string (5 μ m, 4.6mm * 250mm) or the suitable person of other character.Mobile phase is by 0.1% phosphoric acid (H
3PO
4Solvent orange 2 A) and second cyanogen (CH
3CN; Solvent B) forms (Fig. 4).In other illustration, the mobile phase of chromatography condition also can be for by deionized water (solvent orange 2 A) and 80% second cyanogen (CH
3CN; Solvent B) forms.Solvent gradient program setting condition can be shown and following illustration as the 2nd: flow velocity for example can be controlled in 1.0mL/min.The chromatography temperature can maintain 35 ℃.After containing the membrane filtration of the sample for example 0.5 μ m capable of using that educates the extract of sending out cosmetic composition; Carry out the analysis of HPLC finger printing; Wherein inject HPLC systematic sample volume and for example can be 20 μ L, the internal standard article are propyl p-hydroxybenzoate (the propyl paraben of 250 μ g/mL; PPB) solution.The spectrographic wavelength of UV of detecting for example can be 200nm to 380nm.
The 2nd table
See also Fig. 4; It is cosmetic composition is sent out in demonstration according to another embodiment of the present invention through educating of agitator tank gained a HPLC finger printing (finger profile); Wherein transverse axis be the time (minute); The longitudinal axis is trap (A.U.), and curve 401 is the HPLC analysis result of the vegetable matter (raw material) of the 1st table, and curve 403 is to utilize the educate HPLC analysis result of sending out cosmetic composition of the vegetable matter of the 1st table through the agitator tank gained.Result by Fig. 4 can know; Educating of embodiment one sent out cosmetic composition (curve 403) compared to raw material (curve 401); More have more peak value 6 (Radix Polygalae), peak value 8 (Radix Polygalae), peak value 16 (unknown new composition), peak value 17 (Folium Ginkgo), peak value 19 (unknown new composition), salvianolic acid B (salvianolic acid B), schizandrin (Schizandrin) etc., shown in curve 403.
In addition; In other embodiments; The beet alcohol that utilizes the medicinal alcohol of 50% (v/v) or utilize 50% (v/v) is sent out a cosmetic composition through educating of Supersonic wave trough extraction, also can utilize HPLC respectively and after wavelength 254nm, 280nm, 366nm detecting, the HPLC finger printing of gained shows; Utilize the medicinal alcohol of 50% (v/v) or utilize the educating of beet alcohol extraction gained of 50% (v/v) to send out cosmetic composition; Both are at the HPLC finger printing that utilizes after wavelength 254nm, 280nm, 366nm detecting are analyzed, and the distribution of its each peak value all identical (figure does not illustrate) is not given unnecessary details at this in addition.
Embodiment two: the test result of trial volunteer
This embodiment is the trial volunteer with 10, and educating of test implementation example one sent out cosmetic composition to the zest of skin and for educating the effect of sending out, and wherein has 5 experimenters to continue use and reaches 12 months.
1. skin patch test (skin patch test)
Skin patch test (skin patch test) is the inspection technique widely-used at present, that safety is easy again; It mainly is that the assessment test substance touches skin; Whether cause various uncomfortable reactions; For example itch, red, sting, swell, peel, stop using etc., understand the zest of test substance by this to skin.
This embodiment is the trial volunteer with 5, utilizes skin patch test, and assessment contains educating of embodiment one and sends out the zest of cosmetic composition for scalp.The skin patch system of this embodiment is with 8 * 8 square millimeters of (mm
2) the safe patch (Finn of area
Epitest Ltd Oy Finland), does not contain or immerses to contain to educate and send out a cosmetic composition, about 48 hours of the scalp that again this skin patch is attached at the experimenter.Afterwards, take off the skin patch, and in 3 hours, observe and note down experimenter's scalp condition, its result is of the 3rd table.In addition; The experimenter uses in educating of embodiment one send out during 12 months of cosmetic composition; Observe and note down and use the back scalp whether uncomfortable reaction is arranged; For example itch, red, sting, swell, peel, stop using etc., send out cosmetic composition for the adaptive influence of scalp with educating of assessment embodiment one.
The 3rd table
| Scalp condition | Skin patch test (X/Y) | Scalp adaptive testing (X/Y) |
| Itch | 0/5 | 0/5 |
| Red, thorn | 0/5 | 0/5 |
| Swollen | 0/5 | 0/5 |
| Decortication | 0/5 | 0/5 |
| Stop using | 0/5 | 0/5 |
(annotate: the X of the 3rd table representes to have the number of uncomfortable reaction, and Y representes the testing total number.)
Result by the 3rd table can know, skin patch and contain the skin patch that educating of embodiment one sent out cosmetic composition is for scalp nonirritant all.
2. assessment is educated and is sent out effect
This embodiment is the trial volunteer with 10, utilizes skin patch test, and assessment contains educating of embodiment one and sends out cosmetic composition for educating the effect of sending out, and wherein has lasting use of 5 experimenters to reach 12 months, and its result is of the 5th table.
The relevant assessment that improves scalp (or hair) degree of preserving moisture, "+" means and is higher than more than 1.2 times of initial measurement, " 0 " means not have obviously and changes that "-" means 0.9 times that is lower than initial measurement.
The assessment that the sebum of relevant scalp is regulated, "+" means and suppresses experimenter's scalp lipid (being fit to oiliness scalp person), "-" means and promotes experimenter's scalp lipid (being not suitable for oiliness scalp person).
The assessment that the lipid of relevant hair improves, "+" means and is higher than more than 1.2 times of initial measurement, " 0 " means not have obviously and changes that "-" means 0.9 times that is lower than initial measurement.
The assessment of relevant scalp (or hair) pH-value, "+" means compared to the initial measurement pH value to be increased more than 0.2, and " 0 " means not have obviously and changes that "-" means and reduce more than 0.2 compared to initial measurement.
The assessment of relevant color development, the present invention system is with the variable quantity of δZhi gap 1.5, as color development difference measurement index.In specific words, alleged here " δZhi " of the present invention is that expression is according to (the Commission International Del ' Eclairage of International Commission on Illumination; CIE) method for expressing that proposes utilizes colorimeter measurement color development lightness (lighiness; L) variable quantity (L
2-L
1) after, the numerical value that calculates according to following formula (I):
Wherein, L
1For the experimenter use educating of embodiment one send out cosmetic composition before utilize the color development brightness value of colorimeter measurement, L
2For using educating of embodiment one, the experimenter sends out cosmetic composition utilizes colorimeter measurement after a period of time color development brightness value.Generally speaking, the aberration gap that δZhi is represented can be listed like the aberration hierarchical table of the 4th table, and the present invention system is with the variable quantity of δZhi gap 1.5, third level aberration just, as color development difference measurement index:
The 4th table
The assessment of relevant hair growth rate, "+" means that every month, hair was grown up more than 0.2 centimeter (0.2cm/m), " 0 " means not have obviously and changes.
The 5th table
(annotate: the X of the 5th table representes that the number of improving reaction is arranged, and Y representes the testing total number.)
Result by the 5th table can know, utilizes educating of embodiment one to send out a cosmetic composition, really can promote color development increase black, capillus increases, hair is grown up.
What need replenish is; Though the present invention is an illustration with the Chinese herbal medicine of special formulation, specific extraction conditions, particular analysis method or particular instrument; A cosmetic composition and the manufacturing approach thereof of educating of the present invention is described; But those skilled in the art can know under the present invention; The present invention is not limited to this, is not breaking away from the spirit and scope of the present invention, and of the present invention educating sent out cosmetic composition and manufacturing approach can use Chinese herbal medicine, other extraction conditions, other analytical method or the Other Instruments of other prescription to carry out.
Can know by the invention described above embodiment; Of the present invention educating sent out cosmetic composition and manufacturing approach thereof; Its advantage is to utilize a small amount of organic extractant solution one vegetable matter; Wherein this vegetable matter can comprise for example Rhizoma Acori Graminei, Spirulina powder, vitamin B5 and at least one Chinese medicinal herbs, after solid-liquid filtration and micronize processing, can obtain to contain the extract of educating a cosmetic composition again.This educates the use that manufacturing approach of sending out cosmetic composition can effectively be simplified processing procedure and reduce organic solvent, and gained educate send out a cosmetic composition can promote color development increase black, capillus increases, hair is grown up does not have again or significantly reduce thick and heavy taste of Chinese medicine.
Though the present invention with several embodiment openly as above; Right its is not in order to limit the present invention; Those skilled in the art under the present invention; Do not breaking away from the spirit and scope of the present invention, when can doing various changes and retouching, so protection scope of the present invention is as the criterion when looking accompanying the claim person of defining.
Claims (10)
1. educate the manufacturing approach of sending out cosmetic composition for one kind, comprise at least:
Carry out an extraction step; It is in a reactive tank; Temperature with 0 ℃ to 50 ℃; Utilize an organic extractant solution one vegetable matter; Wherein this vegetable matter comprises the Rhizoma Acori Graminei of 2 percentage by weight to 4 percentage by weights, the Spirulina powder of 3 percentage by weight to 5 percentage by weights, the vitamin B5 of 0.5 percentage by weight to 2 percentage by weight and at least one Chinese medicinal herbs of 89 percentage by weight to 94.5 percentage by weights at least, and wherein this at least one Chinese medicinal herbs is selected from a group that is made up of Folium Ginkgo, Semen Cuscutae, Radix Angelicae Sinensis, Cortex Moutan, Radix Rehmanniae Preparata, Fructus Psoraleae, Radix Polygoni Multiflori, the Radix Paeoniae Alba, Rhizoma Polygonati, Fructus Schisandrae Chinensis, Cortex Lycii, Radix Ginseng, Fructus Corni, Rhizoma Zingiberis Recens, Fructus Ligustri Lucidi, Cortex Cinnamomi, Semen Sesami Nigrum, Radix Salviae Miltiorrhizae, Cacumen Platycladi, Rhizoma Chuanxiong, Rhizoma Drynariae, Radix Astragali, Fructus Mori, Fructus Rubi, Radix Polygalae, Semen sojae atricolor, Radix Aconiti Lateralis Preparata and above-mentioned combination in any thereof;
Carry out a solid-liquid separation step, to obtain a filtrating by this organic solution that contains this vegetable matter; And
Carry out a micronize step, to obtain an extract by this filtrating, wherein this extract comprises that this is educated and sends out a cosmetic composition, and this is educated and sends out a cosmetic composition and do not have or significantly reduce taste of Chinese medicine.
2. the manufacturing approach of sending out cosmetic composition of educating according to claim 1; Wherein this organic solution is the mixed solution of ethanol and water; And this ethanol is the ethanol or the Radix Betae ethanol of dehydrated alcohol, 95 percents by volume, and wherein the volume ratio of this ethanol and water is 1: 4 to 3: 2.
3. the manufacturing approach of sending out cosmetic composition of educating according to claim 1, wherein the time of this this vegetable matter of organic extractant solution is 2 hours to 72 hours, and the w/v of this vegetable matter and this organic solution is 0.1g/mL to 0.3g/mL.
4. the manufacturing approach of sending out cosmetic composition of educating according to claim 1; When carrying out this extraction step; More add bittern water in this vegetable matter and this organic solution, and this bittern water is that 0.2% (m/m) is to 0.5% (m/m) in the addition of this organic solution that contains this vegetable matter.
5. the manufacturing approach of sending out cosmetic composition of educating according to claim 1, wherein this reactive tank is an agitator tank, and this agitator tank system with 20 to 50 ℃ temperature by this vegetable matter of this organic extractant solution 2 hours to 72 hours.
6. the manufacturing approach of sending out cosmetic composition of educating according to claim 1, wherein this reactive tank is a Supersonic wave trough, and this Supersonic wave trough frequency of utilizing 30kHz to 70kHz was by this vegetable matter of this organic extractant solution 2 hours to 4 hours.
7. the manufacturing approach of sending out cosmetic composition of educating according to claim 6, wherein this Supersonic wave trough has more a circulating cooling system, makes the temperature maintenance of this Supersonic wave trough when carrying out this extraction step at 0 ℃ to 30 ℃.
8. the manufacturing approach of sending out cosmetic composition of educating according to claim 1, wherein this micronize step is carried out for utilizing ball mill pulverizing method, pneumatic type injection comminuting method or high pressure homogenizing method.
9. the manufacturing approach of sending out cosmetic composition of educating according to claim 1, wherein a median particle diameter (D50) of this extract is 500nm to 1000nm.
10. educate a cosmetic composition for one kind, it is characterized in that this educates a cosmetic composition is that utilization is obtained like arbitrary method of claim 1 to 9.
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| CN1528261A (en) * | 2003-10-08 | 2004-09-15 | 张洪庭 | Shampoo for treating white hair and lipso trichia and eliminating toxicant and preparing method thereof |
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| CN102727859B (en) * | 2012-07-19 | 2013-12-04 | 魏中玉 | Traditional Chinese medicine hair blackening composition, extracting solution thereof and traditional Chinese medicine hair blackening solution |
| CN102727859A (en) * | 2012-07-19 | 2012-10-17 | 重庆港轶生物科技有限公司 | Traditional Chinese medicine hair blackening composition, extracting solution thereof and traditional Chinese medicine hair blackening solution |
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