CN103919888B - A kind of compound hair oil and preparation method thereof - Google Patents
A kind of compound hair oil and preparation method thereof Download PDFInfo
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- CN103919888B CN103919888B CN201410180079.0A CN201410180079A CN103919888B CN 103919888 B CN103919888 B CN 103919888B CN 201410180079 A CN201410180079 A CN 201410180079A CN 103919888 B CN103919888 B CN 103919888B
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Abstract
Compound hair oil of the present invention; Be made up of Radix Cyathulae 12 ~ 18 parts, Radix Morindae Officinalis 9 ~ 12 parts, Fructus Schisandrae Chinensis 8 ~ 13 parts, Radix vernoniae asperae 10 ~ 15 parts, Folium Ginkgo 9 ~ 15 parts, Cacumen Platycladi 15 ~ 22 parts, Semen Plantaginis 12 ~ 18 parts, Radix Angelicae Sinensis 11 ~ 19 parts, Folium Ilicis 15 ~ 18 parts, sodium alginate 18 ~ 23 parts, silicon dioxide powder 15 ~ 22 parts, granada seed oil 18 ~ 25 parts, perilla oil 23 ~ 33 parts.This hair oil preparation method, comprising: A, get Radix Cyathulae, Radix Morindae Officinalis, Fructus Schisandrae Chinensis, Radix vernoniae asperae, Folium Ginkgo, adds 75 ~ 90% ethanol extraction extractum; B, get Cacumen Platycladi, Semen Plantaginis, Radix Angelicae Sinensis, Folium Ilicis make 300 ~ 800 order powder; C, get sodium alginate, silicon dioxide powder, granada seed oil, perilla oil mixing and stirring; D, by the mixture in the extractum in steps A, the powder in step B, step C, join in ultrasonic stirrer and stir.
Description
Technical field
The invention belongs to technical field of medicine preparation, be specially a kind of compound hair oil and preparation method thereof.
Background technology
Women's generation seborrheic alopecia is not rarely seen, and wherein the incidence rate of career woman is usually high than the incidence rate of housewife.For career woman, can because of emulative occupational stress (stress and physical stress etc.), androgen in body is caused to increase, scalp smegma oils and fats is too much, for hair follicle provides the blood capillary of nutrition to shrink, cause hair follicle metabolism suppressed, finally cause a mao atrophy, diminish, a series of change such as trophophase shortening, cause seborrheic alopecia.Climacteric women hormonal balance gets muddled, and along with the stopping gradually of Monitoring Ovarian Function, it is more that hormonal balance temporarily changes androgen into.Hair follicle affects by androgen, can cause the alopecia of similar male pattern alopecia.
Therapeutic Method comprises: 1. Chinese medicine treatment by oral administration of medicines: can select tonification Radix Achyranthis Bidentatae ball or add taste decoction of four noble drugs.Tonification Radix Achyranthis Bidentatae ball selects Achyranthes bidentata Bl, Radix Rehmanniae, Fructus Aurantii, Semen Cuscutae, Cortex Lycii etc., smashes end, honeyed pill processed, for oral administration; Add taste decoction of four noble drugs and select Chinese medicine Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae Preparata, Radix Rehmanniae Preparata etc., decoct decoction and take.2. Chinese medicine external: with Chinese medicinal chrysanthemum, Fructus Viticis, dry Cacumen Platycladi (Cacumen Biotae), Rhizoma Chuanxiong, Cortex Mori dermatome, the Radix Angelicae Dahuricae, Herba Asari, Herba Ecliptae etc., decoction being used as a lotion.Alopecia Chinese traditional treatment method effect is better, and shortcoming is that treatment cycle is slightly long.3. catering therapy: by Cuscuta chinensis, Poria, Semen Nelumbinis meat, Semen Sesami Nigrum, fructus zizaniae caduciflorae etc., add suitable quantity of water after boiling with very hot oven, be cooked into medicated porridge with low baking temperature, add a little Sal and eat it.Every day 1 ~ 2 time, 10 ~ 15 can be serve on.This medicated porridge nourishing kidney yin spleen invigorating, is applicable to the de-originator of nourishing kidney-yin.
Summary of the invention
The object of this invention is to provide a kind of compound hair oil and preparation method thereof, this compound hair oil is applicable to women's seborrheic alopecia.
Compound hair oil of the present invention; Crude drug by following parts by weight: Radix Cyathulae 12 ~ 18 parts, Radix Morindae Officinalis 9 ~ 12 parts, Fructus Schisandrae Chinensis 8 ~ 13 parts, Radix vernoniae asperae 10 ~ 15 parts, Folium Ginkgo 9 ~ 15 parts, Cacumen Platycladi 15 ~ 22 parts, Semen Plantaginis 12 ~ 18 parts, Radix Angelicae Sinensis 11 ~ 19 parts, Folium Ilicis 15 ~ 18 parts, sodium alginate 18 ~ 23 parts, silicon dioxide powder 15 ~ 22 parts, granada seed oil 18 ~ 25 parts, perilla oil 23 ~ 33 parts are made.
As optimization, this compound hair oil, the crude drug by following parts by weight: Radix Cyathulae 14 parts, Radix Morindae Officinalis 11 parts, Fructus Schisandrae Chinensis 10 parts, Radix vernoniae asperae 12 parts, Folium Ginkgo 13 parts, Cacumen Platycladi 18 parts, Semen Plantaginis 16 parts, Radix Angelicae Sinensis 17 parts, Folium Ilicis 16 parts, sodium alginate 20 parts, silicon dioxide powder 18 parts, granada seed oil 23 parts, perilla oil 28 parts are made.
As this compound of optimization hair oil, described silicon dioxide powder particle diameter is 10 ~ 40nm.
Prepare the method for this compound hair oil, comprise the following steps:
A, the Radix Cyathulae of getting described parts by weight, Radix Morindae Officinalis, Fructus Schisandrae Chinensis, Radix vernoniae asperae, Folium Ginkgo, add 75 ~ 90% alcohol reflux 3-4 time, each 2 ~ 3 hours, each 6 ~ 7 times of quantity of solvent, collecting decoction, filters, is condensed into the extractum of 1.00 ~ 1.35 (60 ° of C);
B, the Cacumen Platycladi of getting described parts by weight, Semen Plantaginis, Radix Angelicae Sinensis, Folium Ilicis make 300 ~ 800 order powder;
C, the sodium alginate getting described parts by weight, silicon dioxide powder, granada seed oil, perilla oil add in blender and stir;
D, by the mixture in the extractum in steps A, the powder in step B, step C, join in ultrasonic stirrer, under 52 ~ 68 DEG C of conditions, ultrasonic agitation 2 ~ 3 hours, cooling.
In compound hair oil prescription of the present invention, Radix Cyathulae is dispeled the wind, dampness removing, stimulates the menstrual flow, and invigorates blood circulation.Dispelling the wind and dampness pathogens lumbocrural pain, foot flaccidity clonic spasm of the muscle, stranguria with blood, hematuria, women's amenorrhea, lump in the abdomen.For amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.
Radix Morindae Officinalis reinforcing the kidney and supporting YANG; Bone and muscle strengthening; Expelling wind and removing dampness.Cure mainly impotence due to deficiency of the kidney; Seminal emission premature ejaculation; Cold and pain in the lower abdomen; Incontinence of urine; Cold womb is infertile; Anemofrigid-damp arthralgia; Soreness of the waist and knees; Rheumatism limb gas.
Fructus Schisandrae Chinensis is astringed the lung, nourishing kidney, promotes the production of body fluid, and receives antiperspirant, arresting seminal emission.Control the deficiency of the lung to breath with cough, xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.
The conventional use of Radix vernoniae asperae comprises: angina pectoris, arthritis, bronchial asthma, post-partum pain, cholera, convulsions, tic, spasm, dyspepsia, gonorrhea, hysteria, Liver and kidney problem, measles, pericarditis, rheumatism, scarlet fever, sciatica, scrofula (lymphoid tuberculosis), venom, sexual function are weak, variola, seminal emission tinnitus, pertussis.
Folium Ginkgo is astringed the lung, and relievings asthma, blood circulation promoting and blood stasis dispelling, pain relieving.For cough and asthma due to lung deficiency; Coronary heart disease, angina pectoris, hyperlipidemia, anticoagulant is solid, has certain probability to improve memory.Though Folium Ginkgo energy blood circulation promoting, prevention cardiovascular diseases, but can not be taken other simultaneously and control cardiovascular drugs (such as aspirin), Semen Ginkgo extrac is concentrated granular shape, there is very strong scavenging free radicals and antioxidation, flavonoid glycoside in Folium Ginkgo, aminoacid and Amino acid synthesis collagen protein composition are to human body beauty treatment, and check melanin grows, and keep skin gloss and elasticity to play no small effect.
Cacumen Platycladi feeble QI is fragrant, and the one in bitter and puckery flavor blood-cooling hemostatic, has effect that hemostasis, black beard and hair, cough-relieving are breathed heavily.These product all have inhibitory action to staphylococcus aureus, micrococcus catarrhalis, dysentery bacterium, Bacillus typhi, diphtheria corynebacterium etc.
Semen Plantaginis clearing away heat and promoting diuresis, removing heat from blood, removing toxic substances.Cure mainly accumulation of heat in the urinary bladder, dysuria, stranguria with turbid discharge leukorrhagia, heat-damp in summer dysentery, epistaxis, hematuria, liver-heat conjunctival congestion, laryngopharynx swelling and pain, carbuncle sore tumefacting virus.
Chinese angelica blood supplementing; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation; Cure mainly all cards of blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.
Folium Ilicis falls apart wind heat, refresh oneself, relieving thirst and restlessness.For headache, toothache, conjunctival congestion, calentura excessive thirst, dysentery.Eliminate indigestion and phlegm, relieving restlessness is quenched the thirst, and profit two just, is deoiled greasy, and loose liver-wind, controls Hiccough and deaf, arteries and veins of invigorating blood circulation, cool uterus.Enteritis, burn due to hot liquid or fire, otopyosis, acute mastitis from the beginning of, wind heat, toothache, flaming up of liver-fire, feeling of fullness in the head is dizzy, tinnitus.
Sodium alginate has another name called sodium alginate, seaweed gel, Algin, alginate, is by the natural polysaccharide carbohydrate extracted in Thallus Laminariae (Thallus Eckloniae).Be widely used in the products such as food, medicine, weaving, printing and dyeing, papermaking, daily-use chemical industry, as uses such as thickening agent, emulsifying agent, stabilizing agent, binding agent, sizing agents.
Silicon dioxide is the novel adjuvant of one being used as medicine preparation, is a kind of high-purity, the good white powder of mobility.Be fabulous flow improver additive in tablet manufacturing process, greatly can improve mobility of particle, improve bulk density, the tablet hardness obtained is increased, and disintegration shortens, thus improves drug-eluting speed.Because the extractum of most of Chinese patent medicine has humidity, the characteristic of moisture absorption, and micropowder silica gel has adsorption moisture, promotes the characteristic of flowing.
Granada seed oil can be widely used in medicine and healthcare field.Granada seed oil is also widely used in the middle of cosmetics simultaneously, removes wrinkle, alleviates mild skin allergy and all kinds of inflammatory problems.Granada seed oil contains natural estrogen, has stronger antioxidation, antiinflammatory, antimicrobial characteristic.As a kind of desirable skin-nourishing agent, granada seed oil can nutrition skin, keep skin wet, improve skin elasticity; Balance skin pH value, thus protection skin is encroached on from free radical; The fast quick-recovery of skin of be full of cracks, irriate can be made.
Perilla oil obtains from the seed of Labiatae medicinal plants Folium Perillae (Perillafrutesccns), it is a kind of natural oil of high degree of unsaturation, contained Main Ingredients and Appearance is alpha-linolenic acid, content, up to 50%-70%, is that in all crude vegetals found at present, this content of fatty acid is the highest.The organic perilla oil in long Bai work mill, linolenic acid content, more than 60%, is perilla oil best at present.The edible, medicinal of Fructus Perillae oil has a long history, and Shennong's Herbal is classified as top grade.Have protect the liver, antithrombotic, blood fat reducing, blood pressure lowering, vision protection, improves the effect of intelligence, and has inhibitory action to anaphylaxis and inflammation.
This hair oil plurality of active ingredients combines, and sterilizing, nourishing YIN and benefiting blood, balancing hormones, moisten piliation, is easy to absorb; Treatment women seborrheic alopecia Be very effective.
Pertinent clinical data is as follows:
Physical data: totally 160 examples, sex is women, the oldest 54 years old, minimum 28 years old.Be divided into two groups at random.
Diagnostic criteria: carry out dialectical with reference to " traditional Chinese medical science skin cypridology ".Deficiency of the liver and kindey is demonstrate,proved: alopecia has genetic predisposition more, and patient is based on mental excessive or weakling, and hair becomes soft, sparse, frequently greasy, or increases with dandruff, time have pruritus, or companion's insomnia, poor memory, or companion's waist knee joint expectorant is soft, nocturia, body of the tongue is light red, and tongue is few, thready pulse.Women's seborrheic alopecia, show as the crown splendid ' crown " border circular areas engenders oligotrichosis, hair is often combed forward to cover sparse forehead by women, but still visible hair line hair.
Therapeutic Method: treatment group: by hair oil in the embodiment of the present invention 1, be coated in region of shaving one's head, keep 1 ~ 2 hour at every turn, then clean up, every day three times.One month course for the treatment of.
Matched group: oral finasteride tablet (trade name protects method only, Hangzhou Mo Shadong pharmaceutical Co. Ltd, the accurate word J2oo2oo57 of traditional Chinese medicines), each 1mg, every day 1 time is oral.One month course for the treatment of.
Criterion of therapeutical effect: recovery from illness: alopecia district all covers with hair, but sparse compared with other normal portions, affected part squama, incrustation disappear, and pruritus disappears; Effective: alopecia district covers with hair substantially, but sparse compared with other normal portions, and affected part squama, incrustation disappear, and pruritus alleviates; Effective: alopecia district has kainogenesis long, affected part squama, incrustation reduce, and pruritus takes a turn for the better; Invalid: alopecia district is long without kainogenesis, squama, incrustation, pruritus are unchanged.Efficacy result is in table 1.
Detailed description of the invention
The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; those skilled in the art to nonessential improvement and adjustment more of the present invention, still belong to protection scope of the present invention according to content of the present invention.
Embodiment 1, A, get Radix Cyathulae 14 grams, Radix Morindae Officinalis 11 grams, Fructus Schisandrae Chinensis 10 grams, Radix vernoniae asperae 12 grams, Folium Ginkgo 13 grams, add 75 ~ 90% alcohol reflux 3-4 time, each 2 ~ 3 hours, each 6 ~ 7 times of quantity of solvent, collecting decoction, filters, is condensed into the extractum of 1.00 ~ 1.35 (60 ° of C); B, get Cacumen Platycladi 18 grams, Semen Plantaginis 16 grams, Radix Angelicae Sinensis 17 grams, Folium Ilicis 16 restrain into 300 ~ 800 order powder; C, get sodium alginate 20 grams, Degussa aerosil R974 particle diameter is 12nm, 18 grams, granada seed oil 23 grams, perilla oil 28 grams add in blender and stir; D, by the mixture in the extractum in steps A, the powder in step B, step C, join in ultrasonic stirrer, under 52 ~ 68 DEG C of conditions, ultrasonic agitation 2 ~ 3 hours, cooling.
Embodiment 2, A, get Radix Cyathulae 12 grams, Radix Morindae Officinalis 9 grams, Fructus Schisandrae Chinensis 8 grams, Radix vernoniae asperae 10 grams, Folium Ginkgo 9 grams, add 75 ~ 90% alcohol reflux 3-4 time, each 2 ~ 3 hours, each 6 ~ 7 times of quantity of solvent, collecting decoction, filters, is condensed into the extractum of 1.00 ~ 1.35 (60 ° of C); B, get Cacumen Platycladi 15 grams, Semen Plantaginis 12 grams, Radix Angelicae Sinensis 11 grams, Folium Ilicis 15 restrain into 300 ~ 800 order powder; C, get sodium alginate 18 grams, silicon dioxide powder 15 grams, granada seed oil 18 grams, perilla oil 23 grams add in blender and stir; D, by the mixture in the extractum in steps A, the powder in step B, step C, join in ultrasonic stirrer, under 52 ~ 68 DEG C of conditions, ultrasonic agitation 2 ~ 3 hours, cooling.
Embodiment 3, A, get Radix Cyathulae 18 grams, Radix Morindae Officinalis 12 grams, Fructus Schisandrae Chinensis 13 grams, Radix vernoniae asperae 15 grams, Folium Ginkgo 15 grams, add 75 ~ 90% alcohol reflux 3-4 time, each 2 ~ 3 hours, each 6 ~ 7 times of quantity of solvent, collecting decoction, filters, is condensed into the extractum of 1.00 ~ 1.35 (60 ° of C); B, get Cacumen Platycladi 22 grams, Semen Plantaginis 18 grams, Radix Angelicae Sinensis 19 grams, Folium Ilicis 18 restrain into 300 ~ 800 order powder; C, get sodium alginate 23 grams, silicon dioxide powder 22 grams, granada seed oil 25 grams, perilla oil 33 grams add in blender and stir; D, by the mixture in the extractum in steps A, the powder in step B, step C, join in ultrasonic stirrer, under 52 ~ 68 DEG C of conditions, ultrasonic agitation 2 ~ 3 hours, cooling.
Claims (4)
1. a compound hair oil, it is characterized in that by the crude drug of following parts by weight: Radix Cyathulae 12 ~ 18 parts, Radix Morindae Officinalis 9 ~ 12 parts, Fructus Schisandrae Chinensis 8 ~ 13 parts, Radix vernoniae asperae 10 ~ 15 parts, Folium Ginkgo 9 ~ 15 parts, Cacumen Platycladi 15 ~ 22 parts, Semen Plantaginis 12 ~ 18 parts, Radix Angelicae Sinensis 11 ~ 19 parts, Folium Ilicis 15 ~ 18 parts; Be equipped with the adjuvant of following parts by weight: sodium alginate 18 ~ 23 parts, silicon dioxide powder 15 ~ 22 parts, granada seed oil 18 ~ 25 parts, perilla oil 23 ~ 33 parts are made.
2. compound hair oil according to claim 1, it is characterized in that by the crude drug of following parts by weight: Radix Cyathulae 14 parts, Radix Morindae Officinalis 11 parts, Fructus Schisandrae Chinensis 10 parts, Radix vernoniae asperae 12 parts, Folium Ginkgo 13 parts, Cacumen Platycladi 18 parts, Semen Plantaginis 16 parts, Radix Angelicae Sinensis 17 parts, Folium Ilicis 16 parts; Be equipped with the adjuvant of following parts by weight: sodium alginate 20 parts, silicon dioxide powder 18 parts, granada seed oil 23 parts, perilla oil 28 parts are made.
3. compound hair oil according to claim 1, is characterized in that described silicon dioxide powder particle diameter is 10 ~ 40nm.
4. prepare a method for compound hair oil described in any one of claims 1 to 3, it is characterized in that comprising the following steps:
A, the Radix Cyathulae of getting described parts by weight, Radix Morindae Officinalis, Fructus Schisandrae Chinensis, Radix vernoniae asperae, Folium Ginkgo, add 75 ~ 90% alcohol reflux 3 ~ 4 times, each 2 ~ 3 hours, each 6 ~ 7 times of quantity of solvent, merge extractive liquid, filters, is condensed into the extractum of 1.00 ~ 1.35 at 60 DEG C;
B, the Cacumen Platycladi of getting described parts by weight, Semen Plantaginis, Radix Angelicae Sinensis, Folium Ilicis make 300 ~ 800 order powder;
C, the sodium alginate getting described parts by weight, silicon dioxide powder, granada seed oil, perilla oil add in blender and stir;
D, by the mixture in the extractum in steps A, the powder in step B, step C, join in ultrasonic stirrer, under 52 ~ 68 DEG C of conditions, ultrasonic agitation 2 ~ 3 hours, cooling.
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Citations (4)
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|---|---|---|---|---|
| CN101757062A (en) * | 2008-10-31 | 2010-06-30 | 陈恒树 | Blood-cooling and spirit-quieting hair restorer pill |
| CN102451126A (en) * | 2010-10-15 | 2012-05-16 | 台盐实业股份有限公司 | Hair-growing cosmetic composition, and preparation method thereof |
| CN103479989A (en) * | 2013-09-29 | 2014-01-01 | 蔡铭成 | Natural composite anti-hair-loss hair-growing liquid for external use |
| CN103725491A (en) * | 2012-10-11 | 2014-04-16 | 钱国祥 | Curculigo root health care wine for primary hypertension |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757062A (en) * | 2008-10-31 | 2010-06-30 | 陈恒树 | Blood-cooling and spirit-quieting hair restorer pill |
| CN102451126A (en) * | 2010-10-15 | 2012-05-16 | 台盐实业股份有限公司 | Hair-growing cosmetic composition, and preparation method thereof |
| CN103725491A (en) * | 2012-10-11 | 2014-04-16 | 钱国祥 | Curculigo root health care wine for primary hypertension |
| CN103479989A (en) * | 2013-09-29 | 2014-01-01 | 蔡铭成 | Natural composite anti-hair-loss hair-growing liquid for external use |
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