CN103860958B - A kind of Chinese medicine composition for treating acne - Google Patents
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Abstract
The invention belongs to technical field of Chinese medicines, disclose a kind of Chinese medicine composition for treating acne, it is made up of following raw material: Flos Lonicerae, Flos Chrysanthemi Indici, Herba Taraxaci, Herba Hedyotidis Diffusae, Radix Salviae Miltiorrhizae, the Radix Astragali, Herba Violae, Herba Houttuyniae, Radix Isatidis, Semen Coicis.The present invention is to use natural Chinese medicinal herb, hot, wet, the stasis of blood, the pathogenesis pathology of poison understanding on, with heat clearing away, detoxify, invigorate blood circulation, dampness removing is as Therapeutic Principle, full side sincerely keeps the etiology and pathogenesis of pathogenesis of acne, develops with ball, capsule, granule as dosage form with Modern preparations technique, had both maintained the curative effect of Chinese medicine decoction, facilitate again patient, there are taking convenience, safety, it is simple to the advantage such as carry, the endocrine of human body after taking, can be regulated, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, with strong points, evident in efficacy.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of Chinese medicine composition for treating acne.
Background technology
Acne is one of relatively conventional facial discosmetic dermatosis, and its sickness rate is high.Acne is referred to as " Cuo in Gu doctor's nationality
", " pimples ", " skin ulcer ", " acne ", " whelk ", " winddorn " or " rosacea caused by lung-wind " etc., the modern times are still
Claim " acne ", be commonly called as " comedo ".
It is a kind of sebaceous gland illness that Paederus fuscipes Curtis is common, clinical manifestation be apt to occur in face acne, pimple, pustule,
The pleomorphism skin lesion such as tuberosity are feature, and its pathogenic factor is mainly precocious gland maturity androgen secretion and increases, and have stimulated
Subcutaneous adipose gland, makes hypersteatosis, causes blocking pore and forming acne.In addition antibacterial infection, surfeit fat and sugar class
Also can be ill.The western medicine therapy for the treatment of acne takes following a few class method mainly for etiology.Suppression local inflammation: oral
And externally used antimicrobial element is such as tetracycline, minocycline, metronidazole etc.；Androgen antagonist: oral estrogen, Progesterone, chloroxoquinoline
Lead to；Suppression smegma, improves follicular orifice hyperkeratosis: as with retinoic acid, zinc sulfate etc.；Above therapy is respectively provided with
Certain curative effect, but use western medicine that drug resistance easily occurs, many side effect occur, such as xerostomia, lip decortication, skin
Skin is dried pruritus, gastrointestinal reaction etc., and Women of Childbearing Age takes it also occur that monster.
The traditional Chinese medical science thinks that primary disease is caused by exuberant lung-stomach heat, influenza ailment said due to cold or exposure.Primary disease is apt to occur in face, shirtfront, shoulder back and skin
The position that adipose gland is many, some as syringe needle, Semen Sesami size pore pimple, blush around pimple, there is black point at top, also
Claiming " blackhead ", have white paste to discharge during extruding, can continue development and form pustule acne, inflammation severe patient can be sent out
The hard mealiness of generated or acne cystica.The doctor trained in Western medicine cause of disease had both been used for reference in the treatment of the traditional Chinese medical science, had used again the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of the traditional Chinese medical science, mark
That originally takes into account is adjusted from internal body pathological change, so the research effective Chinese medicine of low toxicity becomes to attach most importance to further.
Summary of the invention
The technical problem to be solved is to provide a kind of effective, safe and reliable for treating in acne
Drug composition.
The technical problem to be solved realizes by the following technical solutions:
A kind of Chinese medicine composition for treating acne, is made up of the crude drug of following weight portion,
Flos Lonicerae 8-20 part, Flos Chrysanthemi Indici 5-15 part, Herba Taraxaci 20-40 part, Herba Hedyotidis Diffusae 5-15 part, Radix Salviae Miltiorrhizae 8-20
Part, Radix Astragali 5-15 part, Herba Violae 5-15 part, Herba Houttuyniae 5-15 part, Radix Isatidis 5-15 part, Semen Coicis 8-10 part.
Preferred weight part of each crude drug is:
Flos Lonicerae 10-15 part, Flos Chrysanthemi Indici 8-12 part, Herba Taraxaci 25-35 part, Herba Hedyotidis Diffusae 8-12 part, Radix Salviae Miltiorrhizae 10-15
Part, Radix Astragali 8-12 part, Herba Violae 8-12 part, Herba Houttuyniae 8-12 part, Radix Isatidis 8-12 part, Semen Coicis 10-15
Part.
The preferred weight portion of each crude drug is:
Flos Lonicerae 12 parts, Flos Chrysanthemi Indici 10 parts, Herba Taraxaci 30 parts, Herba Hedyotidis Diffusae 10 parts, Radix Salviae Miltiorrhizae 12 parts, the Radix Astragali
10 parts, Herba Violae 10 parts, Herba Houttuyniae 10 parts, Radix Isatidis 10 parts, Semen Coicis 12 parts.
Crude drug used in the present invention can be commercially available from common Chinese shop, and its specification meets country's Chinese crude drug standard.
It is a further object to provide a kind of method preparing the present composition, comprise the steps,
Weigh the Flos Lonicerae of recipe quantity, Flos Chrysanthemi Indici, Herba Taraxaci, Herba Hedyotidis Diffusae, the Radix Astragali, Herba Violae, Herba Houttuyniae, plate
Lan Gen, Semen Coicis decoct twice, add ten times amount water for the first time, and second time adds octuple amount water, adds 73% ethanol alcohol after concentration
Heavy, cold preservation stands 48 hours；Weigh Radix Salviae Miltiorrhizae by proportioning to add 70% ethanol and carry out reflux, extract, decoct twice, backflow cold preservation
Stand 48 hours；Will stand after collect medical filtration, concentration, reach about density 1.21-1.41, then use 200 mesh
Filter-cloth filtering, receives in container, makes extractum, finally directly or adds pharmaceutically acceptable excipient system through normal process steps
Become clinically-acceptable dosage form.
Preferably, described density is about 1.31.
Preferably, described Chinese medicine composition can be prepared as oral formulations.It is further preferred that described oral formulations is soup
Agent, pill, capsule, granule.
In Chinese medicine composition for treating acne of the present invention, the pharmacology analysis of its each raw material is as follows:
Flos Lonicerae: cold in nature, sweet in the mouth, kind heat-clearing and toxic substances removing, food the most suitable." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: Flos Lonicerae heat clearing away, solves
All skin ulcers." SHENGCAO medicine standby will " says that it goes skin heat in blood.Essentials of Matea Medica is also known as: control scabies.
Flos Chrysanthemi Indici: dissipate wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, dizziness of having a headache, conjunctival congestion and swelling pain, eyes is dim-sighted." this
Grass is through dredging ": Flos Chrysanthemi autocracy wind wood, therefore for going the key medicine of wind.Hardship can expel the heat-evil, sweet can benefit blood, sweet detoxify, flat then hold concurrently pungent,
Therefore also eliminating stagnation, Ku Renxin, small intestinal, sweet flavour associating with spleen, stomach, flat pungent walk liver, gallbladder, double enter abundant and large intestine.Its main air dizziness, swollen
Bitterly, mesh be intended to take off, lacrimation, the dead flesh of skin, aversion to wind, arthralgia chiefly caused by damp pathogen person, all wind trembling and dizziness, all belong to edema with the liver involved, wind medicine ancestor liver, liver opens
Key, in mesh, wind being YANG-pathogen, certainly will be gone on, and blood deficiency is the hottest, and heat then gives birth to wind, wind-fire fight mutually thus also.Lumbago goes happy person,
Be the time of the blood deficiency stagnation of QI, bitter to let out stagnant knot, sweet with benefit blood vessels, pungent flat with scattered deficiency-heat also.Its remove irritable feverish sensation in the chest person, the main blood of the heart,
Void is then sick is tired of, in deficiency of YIN causing heat syndrome closes at, therefore heat is in the heart, and blood benefit is then cloudy raw, and cloudy life is then tired, and only toil can expel the heat-evil, therefore tired
Heat also solves.Peace the intestines and stomach, profit five pulse conditions of ZANG-organs, adjust extremity, profit vim and vigour person, i.e. heat extraction, dispel the wind, benefit blood, enter the heart, enter spleen, enter liver
Test also.Raw smashing most treats skin ulcer, and blood line furuncle particularly key medicine, the poison for the treatment of person's wind-fire is also.
" Bencao Jingshu ": Herba Taraxaci is hidden sweet flat, and its property is nontoxic.When being to enter stomach, the key medicine of antipyretic removing heat from blood into liver." book on Chinese herbal medicine
Justice ": Herba Taraxaci, its property is refrigerant, controls all and treats skin ulcer, carbuncle and ulcer, the red and swollen all cards of pyretic toxicity, can take and can apply, quite have confirmed.
The micro-hardship of Herba Hedyotidis Diffusae property is sweet cold, returns stomach, large intestine channel, has heat-clearing and toxic substances removing, the effect of eliminating carbuncle of invigorating blood circulation, for furuncle and prickly heat carbuncle
The key medicine of infections；Modern Chinese medicine pharmacological research shows, Herba Hedyotidis Diffusae has antibacterial a, antiinflammation, improving immunocompetence,
Can stimulate reticuloendothelial system, strengthen cell phagocytic activity, play anti-infectious function, and have androgen antagonist sample effect and
Suppression smegma effect.Radix Salviae Miltiorrhizae: bitter, be slightly cold, GUIXIN, Liver Channel, there is promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood disappears
Carbuncle, the effects such as clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.The Radix Astragali: sweet in the mouth, slightly warm in nature, there is the effects such as invigorating QI to consolidate the body surface resistance, torr skin ulcer granulation promoting.
" Bencao Congxin " records the Radix Astragali, beats reason, tonifying the lung gas in fact, lets out YIN-fire, expelling pathogenic factors from muscles heat, processs and use invigorating middle warmer, benefit vigour, Wen Sanjiao,
Strong taste.Herba Violae: bitter, acrid, cold is nontoxic；GUIXIN, Liver Channel, be used as medicine, its mildly bitter flavor cold in nature, heat-clearing and toxic substances removing,
Removing heat from blood is subsided a swelling.Herba Houttuyniae: cold nature, bitter in the mouth, heat-clearing and toxic substances removing, removing pus and relieving carbuncle, inducing diuresis for treating stranguria syndrome.Radix Isatidis: there is heat clearing away,
The effects such as removing toxic substances, dispels the wind, dehumidifying.Semen Coicis: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal.For edema, tinea pedis, dysuria,
Arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen.
The present invention is to fumigate in upper based on acne in theory of Chinese medical science is many because of lung-heat, and heat in blood accumulates resistance skin；Because of the pungent savoury of surfeit,
Then giving birth to damp and hot, superinverse causes in skin.Also have because of spleen insufficiency, phlegm-damp pent-up with the passing of time stagnation of QI-blood, phlegm and blood stasis, stagnate
In skin.Also having because of deficiency of kidney yin, the imbalance between YIN and YANG of kidney, the most prosperous and fecula thorn crossed by fire mutually.Also have because of Chong and Ren channel disorder, the heart
The high Sheng of fire etc..Treatment is worked as with cleaning lung stomach damp and hot, and the expectorant stasis of blood is dissolved in removing pathogenic heat from blood and toxic substance from the body, and yin nourishing is empty, adjusts the methods such as punching times.Because of herein
Fang Zhongxu heat clearing away class medicine, blood stasis dispelling class medicine are main.Such as clearing away heat and eliminating dampness medicine Flos Lonicerae, Herba Hedyotidis Diffusae, Radix Isatidis etc.；Rush down
Fire antidote Herba Violae, Semen Coicis etc.；Removing heat from blood and promoting blood circulation medicine Radix Salviae Miltiorrhizae etc., removing toxicity for eliminating carbuncles suppuration medicine Flos Chrysanthemi Indici, Herba Taraxaci etc..
The present invention compared to existing technology have the beneficial effect that the present invention be use natural Chinese medicinal herb, make treatment acne medicine
Preparation, hot, wet, the stasis of blood, the pathogenesis pathology of poison understanding on, with heat clearing away, detoxify, invigorate blood circulation, dampness removing as Therapeutic Principle,
Full side sincerely keeps the etiology and pathogenesis of pathogenesis of acne, combines modern Chinese medicine pharmacological research on the basis of differential diagnosis in tcm opinion is controlled, ginseng west in inner feelings,
Dialectical unify mutually with differential diagnosis of diseases, given full play to the unique advantage of Chinese medicine.Chinese medicine composition of the present invention change Chinese medicine decoction it
Dosage form, develops with ball, capsule, granule as dosage form with Modern preparations technique, had both maintained the curative effect of Chinese medicine decoction, and facilitated again
Patient, has taking convenience, safety, it is simple to the advantage such as carry.Can be with heat-clearing and toxic substances removing after taking, blood circulation promoting and blood stasis dispelling, eliminating stagnation,
Cure face or the acne of chest and back, reach the effect of face and skin beautifying；With strong points, evident in efficacy, have no side effect.
Pharmacological testing shows: how many in keratinization degree, epidermis thickened degree, hair follicle degrees of expansion, hair follicle interior angle compound matter and
5 aspects of cell infiltration, compare with modeling blank group, it is seen that lesion degree has different alleviating.Through statistical procedures, in
Dosage group, positive controls and high dose group compare with modeling blank group significant difference (P ＜ 0.01), and agent in this medicine is described
Amount group and high dose group have obvious anti-keratinous effect；Low dose group compares with modeling blank group significant difference (P ＜ 0.05),
Certain anti-keratinization ability is described.
After being administered 2 weeks, can significantly reduce rabbit anteserum testosterone concentration, under Isodose, its action effect is better than positive control
Group, it is notable that high dose group reduces serum testosterone effect.Model blank group sebaceous gland diameter, hair follicle area are above normally
Group, difference has significance, further illustrates modeling success.The sebaceous gland diameter of high, medium and low dosage group is less than and touches type group,
Difference has significance.The sebaceous gland diameter of high, medium and low dosage group becomes positive correlation, positive controls and middle dosage group with dosage
Similar.Visible, acne can safely and effectively be treated by the medicine that the present invention prepares.
Detailed description of the invention
For the technological means making the present invention realize, creation characteristic, reach purpose and be easy to understand with effect, below in conjunction with
Specific embodiment, is expanded on further the present invention.
Embodiment 1, a kind of Chinese medicine composition for treating acne
Flos Lonicerae 11 parts, Flos Chrysanthemi Indici 9 parts, Herba Taraxaci 29 parts, Herba Hedyotidis Diffusae 9 parts, Radix Salviae Miltiorrhizae 11 parts, the Radix Astragali 9 parts,
Herba Violae 9 parts, Herba Houttuyniae 9 parts, Radix Isatidis 9 parts, Semen Coicis 11 parts.
Weigh the Flos Lonicerae of recipe quantity, Flos Chrysanthemi Indici, Herba Taraxaci, Herba Hedyotidis Diffusae, the Radix Astragali, Herba Violae, Herba Houttuyniae, plate
Lan Gen, Semen Coicis decoct and are for twice 1.5 hours, add ten times amount water for the first time, and second time adds octuple amount water, after concentration
Adding 73% ethanol precipitate with ethanol, cold preservation stands 48 hours；Weigh Radix Salviae Miltiorrhizae by proportioning to add 70% ethanol and carry out reflux, extract, decoct twice,
Backflow cold preservation stands 48 hours；Will stand after collect medical filtration, concentration, reach density about 1.31, then use
200 mesh filter-cloth filterings, receive in container, make extractum, finally directly or add pharmaceutically acceptable tax through normal process steps
Clinically-acceptable capsule is made in shape agent.
Embodiment 2, a kind of Chinese medicine composition for treating acne
Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 5 parts, Herba Taraxaci 40 parts, Herba Hedyotidis Diffusae 5 parts, Radix Salviae Miltiorrhizae 20 parts, the Radix Astragali 5 parts,
Herba Violae 15 parts, Herba Houttuyniae 5 parts, Radix Isatidis 15 parts, Semen Coicis 8 parts.
Weigh the Flos Lonicerae of recipe quantity, Flos Chrysanthemi Indici, Herba Taraxaci, Herba Hedyotidis Diffusae, the Radix Astragali, Herba Violae, Herba Houttuyniae, plate
Lan Gen, Semen Coicis decoct and are for twice 1.5 hours, add ten times amount water for the first time, and second time adds octuple amount water, after concentration
Adding 73% ethanol precipitate with ethanol, cold preservation stands 48 hours；Weigh Radix Salviae Miltiorrhizae by proportioning to add 70% ethanol and carry out reflux, extract, decoct twice,
Backflow cold preservation stands 48 hours；Will stand after collect medical filtration, concentration, reach density about 1.21, then use
200 mesh filter-cloth filterings, receive in container, make extractum, finally directly or add pharmaceutically acceptable tax through normal process steps
Clinically-acceptable capsule is made in shape agent.
Embodiment 3, a kind of Chinese medicine composition for treating acne
Flos Lonicerae 10 parts, Flos Chrysanthemi Indici 12 parts, Herba Taraxaci 25 parts, Herba Hedyotidis Diffusae 12 parts, Radix Salviae Miltiorrhizae 10 parts, the Radix Astragali 12
Part, Herba Violae 8 parts, Herba Houttuyniae 12 parts, Radix Isatidis 8 parts, Semen Coicis 15 parts.
Weigh the Flos Lonicerae of recipe quantity, Flos Chrysanthemi Indici, Herba Taraxaci, Herba Hedyotidis Diffusae, the Radix Astragali, Herba Violae, Herba Houttuyniae, plate
Lan Gen, Semen Coicis decoct and are for twice 1.5 hours, add ten times amount water for the first time, and second time adds octuple amount water, after concentration
Adding 73% ethanol precipitate with ethanol, cold preservation stands 48 hours；Weigh Radix Salviae Miltiorrhizae by proportioning to add 70% ethanol and carry out reflux, extract, decoct twice,
Backflow cold preservation stands 48 hours；Will stand after collect medical filtration, concentration, reach density about 1.41, then use
200 mesh filter-cloth filterings, receive in container, make extractum, finally directly or add pharmaceutically acceptable tax through normal process steps
Clinically-acceptable capsule is made in shape agent.
Embodiment 4, a kind of Chinese medicine composition for treating acne
Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 5 parts, Herba Taraxaci 40 parts, Herba Hedyotidis Diffusae 5 parts, Radix Salviae Miltiorrhizae 20 parts, the Radix Astragali 5 parts,
Herba Violae 15 parts, Herba Houttuyniae 5 parts, Radix Isatidis 15 parts, Semen Coicis 8 parts.
Preparation method is with embodiment 1.
Embodiment 5, a kind of Chinese medicine composition for treating acne
Flos Lonicerae 15 parts, Flos Chrysanthemi Indici 8 parts, Herba Taraxaci 35 parts, Herba Hedyotidis Diffusae 12 parts, Radix Salviae Miltiorrhizae 10 parts, the Radix Astragali 12
Part, Herba Violae 8 parts, Herba Houttuyniae 12 parts, Radix Isatidis 8 parts, Semen Coicis 15 parts.
Preparation method is with embodiment 1.
Embodiment 6, a kind of Chinese medicine composition for treating acne
Flos Lonicerae 11 parts, Flos Chrysanthemi Indici 11 parts, Herba Taraxaci 29 parts, Herba Hedyotidis Diffusae 11 parts, Radix Salviae Miltiorrhizae 11 parts, the Radix Astragali 9
Part, Herba Violae 11 parts, Herba Houttuyniae 9 parts, Radix Isatidis 11 parts, Semen Coicis 11 parts.
Preparation method is with embodiment 1.
Embodiment 7, a kind of Chinese medicine composition for treating acne
Flos Lonicerae 13 parts, Flos Chrysanthemi Indici 9 parts, Herba Taraxaci 31 parts, Herba Hedyotidis Diffusae 9 parts, Radix Salviae Miltiorrhizae 13 parts, the Radix Astragali 11 parts,
Herba Violae 9 parts, Herba Houttuyniae 11 parts, Radix Isatidis 9 parts, Semen Coicis 13 parts.
Preparation method is with embodiment 1.
Embodiment 8, a kind of Chinese medicine composition for treating acne
Flos Lonicerae 12 parts, Flos Chrysanthemi Indici 10 parts, Herba Taraxaci 30 parts, Herba Hedyotidis Diffusae 10 parts, Radix Salviae Miltiorrhizae 12 parts, the Radix Astragali
10 parts, Herba Violae 10 parts, Herba Houttuyniae 10 parts, Radix Isatidis 10 parts, Semen Coicis 12 parts.
Preparation method with embodiment 1, finally through normal process steps directly or add pharmaceutically acceptable excipient make clinic can
The pill accepted.
Embodiment 9, a kind of Chinese medicine composition for treating acne
Flos Lonicerae 12 parts, Flos Chrysanthemi Indici 10 parts, Herba Taraxaci 30 parts, Herba Hedyotidis Diffusae 10 parts, Radix Salviae Miltiorrhizae 12 parts, the Radix Astragali
10 parts, Herba Violae 10 parts, Herba Houttuyniae 10 parts, Radix Isatidis 10 parts, Semen Coicis 12 parts.
Preparation method with embodiment 1, finally through normal process steps directly or add pharmaceutically acceptable excipient make clinic can
The granule accepted.
Embodiment 10, the anti-keratinous effect of Acne Model experimental to the rabbit ear
1 experiment
L.1 material
Health orchid rabbit at the new tenth of the twelve Earthly Branches 48, male and female half and half, body weight (2.5 ± 0.2) kg, fed standard chow.
Coal tar (commercially available), BX-50 type Olympus optical microscope.
Tanshinone capsule, 0.25 gram × 24, batch number: 20110320, Hebei Xinglong Xili Pharmaceutical Co., Ltd., state
Medicine quasi-word Z13020110.
1.2 method
1.2.1 modeling and administration
Taking 8 rabbits at random is normal group, is not coated with coal tar；Remaining 40 rabbits, inside ears, syrinx opens 2cm × 2cm at day
Scope, is coated with 0.25 coal tar every day 2 times, continuous 2 weeks.After modeling 2 weeks, it is randomly divided into 5 groups, often group 8, wherein
L group is model blank group, gastric infusion, 1 time/d, and dosage is respectively as follows: low dose group 0.563g/kg (adult's clinic
Consumption 3 times), middle dosage group 1.125g/kg (adult quantity 6 times), high dose group 1.688g/kg(adult's clinic use
Measure 9 times), positive control drug (tanshinone capsule) 2.250g/kg (adult's quantity 6 times), successive administration 2 weeks.
L.2.2 pathological study
Result of determination, last is administered latter 24 hours, takes serum and surveys testosterone concentration, then takes auricle, and 10% formaldehyde is fixed, stone
Wax embed, serial section, conventional H E dye, under light microscopic tissues observed change, from keratinization degree, epidermis thickened degree,
Hair follicle degrees of expansion, hair follicle interior angle compound matter is how many and 5 each side such as cell infiltration carry out pathology by histological score standard
Change comprehensive score, be shown in Table 1.
Table 1, histological observation standards of grading
2 results
2.1 meat clothes are observed
The normal group rabbit ear is poor, soft, blood capillary, follicular orifice marshalling seen from rabbit ear pipe clearly seen from it；
The modeling blank group rabbit ear thickens, rough surface, and pore increases, with yellow pimple；
Low dose group hair follicle keratotic plug reduces inconspicuous, however it remains；
High dose group hair follicle keratotic plug reduces substantially, and part keratotic plug leaves over the hair follicle of pitting after coming off, and pimple flattens minimizing；
Positive controls is similar to middle dosage group, though rabbit ear portion pimple has been recovered, but still visible obvious hair follicle keratotic plug, skin
The most coarse plumpness of skin, shrinking pore is inconspicuous.
2.2 histological findings
Normal group, rabbit ear epidermis is relatively thin, about l layer granular layer, layer 2-4 prickle cell layer, the accidental cell infiltration of skin corium,
Corium, epidermal junction understand, it is seen that hair follicle；
Modeling blank group, epidermis and follicular epithelium irregular thickening, granular layer substantially thickens, acanthosis, hair follicle four round angle
Changing layer substantially to thicken, the hair follicle of adjacent expansion mutually merges, and is full of keratinization thing in hair follicle chamber, and inflammatory cell infiltration is more；
Low dose group hair follicle keratotic plug has reduced but inconspicuous, and epidermis is 4-5 layer；
Middle dosage group hair follicle keratotic plug, inflammatory infiltration reduce, and granular layer, prickle cell layer are thinning, but still visible plump prickle cell layer
And granular layer, there is keratinization material filling in hair follicle, a little inflammatory cell infiltration is shown in by corium.
High dose group hair follicle keratotic plug, inflammatory infiltration significantly reduce, and granular layer, prickle cell layer are the most thinning；
Positive controls epidermis thickens and alleviates, and still visible plump prickle cell layer and granular layer, have keratinization material filling in hair follicle,
A little inflammatory cell infiltration is shown in by corium.
Microscopic observation, be administered each group compared with modeling blank group, pathological changes has alleviating in various degree, but still has a small amount of loose angle
Compound matter is filled, dermal inflammation Leukopenia, but visible inmature hair follicle in various degree is formed.
The table 2. impact on rabbit ear Acne Model anti-keratinous effect
It can be seen that in keratinization degree, epidermis thickened degree, hair follicle degrees of expansion, hair follicle interior angle compound matter how many and inflammatory cell
Infiltrate 5 aspects, compare with modeling blank group, it is seen that lesion degree has different alleviating.Through statistical procedures, middle dosage group,
Positive controls and high dose group compare with modeling blank group significant difference (P ＜ 0.01), and dosage group and height in this medicine are described
Dosage group has obvious anti-keratinous effect；Low dose group compares with modeling blank group significant difference (P ＜ 0.05), and explanation has
Certain anti-keratinization ability.
The table 3. impact on Acne Model anti-keratinous effect
With rank test, compare with modeling blank group, * P ＜ 0.05, * * P ＜ 0.01.
2.3 impacts on Testosterone Content in Serum
Result (table 4) shows: after modeling 2 weeks, rabbit ear Acne Model testosterone concentration significantly raises.After being administered 2 weeks, energy
Significantly reducing rabbit anteserum testosterone concentration, under Isodose, its action effect is better than positive controls, and high dose group reduces blood
Clear testosterone effect is notable.
Table 4 is taken medicine the comparison of before and after's rabbit anteserum testosterone levels
Compare with modeling blank group, * P ＜ 0.05, * * P ＜ 0.01.
2.4 respectively organize sebaceous gland and hair follicle Area comparison under mirror
Model blank group sebaceous gland diameter, hair follicle area are above normal group, and difference has significance, further illustrate modeling
Merit.The sebaceous gland diameter of high, medium and low dosage group is less than touching type group, and difference has significance.The skin of high, medium and low dosage group
Adipose gland diameter becomes positive correlation with dosage, and positive controls is similar to middle dosage group.
This test shows, Chinese medicine composition of the present invention has preferable anti-keratinous effect to experimental rabbit ear Acne Model.To epidermis
The expansion of keratinization, hair follicle, hair follicle interior angle compound matter, inflammatory infiltration, promotion virgin wool Tibetan household slave one-tenth, hair follicle area and sebaceous gland diameter
Aspect has effect, and becomes positive correlation with dosage.Visible, acne can safely and effectively be treated by the medicine that the present invention prepares.
Certainly, described above is not limitation of the present invention, and the present invention is also not limited to the example above, the art
Those of ordinary skill, in the essential scope of the present invention, the change made, retrofits, adds or replaces, all should belong to this
Bright protection domain.
Claims (4)
1. the Chinese medicine composition being used for treating acne, it is characterized in that, be made up of the raw material of following parts by weight: Flos Lonicerae 12 parts, Flos Chrysanthemi Indici 10 parts, Herba Taraxaci 30 parts, Herba Hedyotidis Diffusae 10 parts, Radix Salviae Miltiorrhizae 12 parts, the Radix Astragali 10 parts, Herba Violae 10 parts, Herba Houttuyniae 10 parts, Radix Isatidis 10 parts, Semen Coicis 12 parts.
A kind of Chinese medicine composition for treating acne, it is characterized in that, its preparation method is: weigh the Flos Lonicerae of recipe quantity, Flos Chrysanthemi Indici, Herba Taraxaci, Herba Hedyotidis Diffusae, the Radix Astragali, Herba Violae, Herba Houttuyniae, Radix Isatidis, Semen Coicis decoct twice, add ten times amount water for the first time, second time adds octuple amount water, adding 73% ethanol precipitate with ethanol after concentration, cold preservation stands 48 hours；Weighing Radix Salviae Miltiorrhizae by proportioning to add 70% ethanol and carry out reflux, extract, decoct twice, backflow cold preservation stands 48 hours；The medical filtration that to collect after standing, concentration, reach density 1.21-1.41, then with 200 mesh filter-cloth filterings, receive in container, make extractum, finally direct through normal process steps or add pharmaceutically acceptable excipient and make clinically-acceptable dosage form.
A kind of Chinese medicine composition for treating acne, it is characterised in that described Chinese medicine composition is prepared as oral formulations.
A kind of Chinese medicine composition for treating acne, it is characterised in that described oral formulations is pill, capsule or granule.
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| CN104146942A (en) * | 2014-08-29 | 2014-11-19 | 桂林市艾康科技有限公司 | Bamboo liquid facial mask for resisting inflammatory and senescence |
| CN104208514A (en) * | 2014-09-16 | 2014-12-17 | 于向英 | Composition for treating hairline sore |
| CN105267300A (en) * | 2014-12-26 | 2016-01-27 | 完美（中国）有限公司 | Acne removing traditional Chinese medicine composition |
| CN104721349B (en) * | 2015-04-12 | 2017-12-19 | 卫俊斗 | A kind of Xiao Cuo Jie Fu Cream Chinese medicine composition and preparation method thereof |
| CN104857078A (en) * | 2015-06-09 | 2015-08-26 | 徐艳 | Medicinal preparation for treating acne |
| CN106177635A (en) * | 2016-08-30 | 2016-12-07 | 陈秀华 | A kind of Chinese medicine composition for anti-acne and the application in mask product thereof |
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