CN104147198A - Traditional Chinese medicine compound for treating papular acne and preparation thereof - Google Patents
Traditional Chinese medicine compound for treating papular acne and preparation thereof Download PDFInfo
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- CN104147198A CN104147198A CN201410428777.8A CN201410428777A CN104147198A CN 104147198 A CN104147198 A CN 104147198A CN 201410428777 A CN201410428777 A CN 201410428777A CN 104147198 A CN104147198 A CN 104147198A
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Abstract
The invention relates to the field of cosmetics and provides a traditional Chinese medicine compound for treating papular acne and a preparation thereof. The compound is prepared from following raw materials comprising greater celandine, honeysuckles, sophora flavescens, cortex phellodendri, dandelion, sophora flowers, dictamnus dasycarpus turcz and borneol. The traditional Chinese medicine compound is simple in medicines, is an external-use embrocation liniment, is high in effective rate and is free of toxic and side effects.
Description
Technical field
The invention belongs to cosmetic field, relate to a kind of pharmaceutical composition with acne-removing and preparation method thereof, particularly a kind of acne papulosa Chinese medicine compound and preparation method thereof for the treatment of.
Background technology
Acne papulosa is that Semen setariae, to pea-sized hard little pimple, is pale red to peony because it is main that skin lesion causes the little pimple of inflammatory.Can there be the not seborrheic plug of blackening of a blackhead or top in pimple central authorities.
The pathology cause of disease of acne papulosa has following several:
Endocrine factors: acne papulosa and property endocrine have close relationship: adolescence is few morbidity in the past, sexual function forfeiture or the people of going down do not fall ill; Application testosterone increases, and can impel the growth of beard and the generation of acne papulosa; During by thyroliberin or corticosteroid hormone treatment disease, often cause acne papulosa; Women premenstrually often has an acne papulosa outbreak in the moon.
The effect of sebum: the growth of sebaceous gland is also relevant with androgen increase with the secretion of sebum, wherein increases the effect of sebaceous gland activeness with testosterone the strongest, causes that sebum secretion increases, and stops up pore, forms acne and acne papulosa.
Microorganism in hair follicle: the acne papulosa corynebacterium existing in hair follicle, Staphylococcus albus and oval pityriasis sporeformer, make hair follicle and hair follicle that non-particularity inflammatory reaction occur around, near the atomic ulcer of acne wall and free fatty enter after corium, add near the cell of blackhead extruding, make their antimicrbial power decline and caused inflammation by the infection of antibacterial, so acne papulosa occurs patient.
Current Therapeutic Method mainly contains: local cleaning: with clear water, wash one's face, remove the mixture of oils and fats, scurf and the antibacterial of skin surface, avoid with oils, powder class skin care cosmetics and the ointment machin cream that contains glucocorticoid composition.Acupuncture and moxibustion treatment: after often selecting the uniform reinforcing-reducing method Protective Erfect of Acupunctures such as cave big vertebra, Pishu, tsu san li, connected valleys, sp 6, let the acupuncture needle remain at a certain point 30 minutes, every day 1 time, is for 7 times 1 course for the treatment of.Auriculotherapy: patient's bilateral ear lung point of take is master point, is equipped with Shenmen, sympathetic, endocrine, subcortex point and buries Semen Vaccariae seed, 3 times, the upper cave of external immobilization with adhesive tape massage every day, each approximately 10 minutes.Dietetic therapy: patient declares high sugared, higher fatty acid, the wine of few food, the irritable food such as pungent, polyphagia vegetable (bean sprout, green vegetable, Caulis et Folium Chrysanthemi segeti, Fructus Benincasae, Fructus Luffae, Fructus Momordicae charantiae, Corm Eleocharitis) and fruit.
Although right above-mentioned therapy has certain preventive and therapeutic effect, has inconvenience, be difficult to obtain desirable therapeutic effect.
Summary of the invention
Object of the present invention provides a kind of pharmaceutical composition with acne-removing and preparation method thereof, particularly a kind of acne papulosa Chinese medicine compound and preparation method thereof for the treatment of.
The technical solution used in the present invention: a kind of acne papulosa Chinese medicine compound for the treatment of, is prepared from by the raw material of following weight portion:
Herba Chelidonii 6-9 part Flos Lonicerae 6-9 part Radix Sophorae Flavescentis 4-8 part Cortex Phellodendri 4-8 part
Herba Taraxaci 3-6 part Flos Sophorae 4-6 part Cortex Dictamni 4-6 part Borneolum Syntheticum 0.01-0.05 part
As one of preferred technical scheme, be:
Bend 6 parts of 6 portions of Cortex Phellodendris of 8 parts of Radix Sophorae Flavescentiss of 8 portions of Flos Loniceraes of dish
0.01 part of 4 parts of Borneolum Syntheticum of 6 parts of Cortex Dictamni of 3 parts of Flos Sophoraes of Herba Taraxaci
As two of preferred technical scheme, be:
6 parts of 6 portions of Cortex Phellodendris of 6 parts of Radix Sophorae Flavescentiss of 9 portions of Flos Loniceraes of Herba Chelidonii
0.02 part of 4 parts of Borneolum Syntheticum of 4 parts of Cortex Dictamni of 6 parts of Flos Sophoraes of Herba Taraxaci
As three of preferred technical scheme, be:
4 parts of 4 portions of Cortex Phellodendris of 9 parts of Radix Sophorae Flavescentiss of 6 portions of Flos Loniceraes of Herba Chelidonii
0.01 part of 6 parts of Borneolum Syntheticum of 6 parts of Cortex Dictamni of 3 parts of Flos Sophoraes of Herba Taraxaci
The present invention also provides a kind of preparation method for the treatment of acne papulosa Chinese medicine compound external application Chinese medicine liniment, it is characterized in that: comprise the steps:
1. first Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae, Cortex Dictamni are ground into respectively to 20-40 order powder.
2. from powder, take Herba Chelidonii 6-9 part, Flos Lonicerae 6-9 part, Radix Sophorae Flavescentis 4-8 part, Cortex Phellodendri 4-8 part, Herba Taraxaci 3-6 part, Flos Sophorae 4-6 part, Cortex Dictamni 4-6 part.
3. 8 times of amount 95% alcohol reflux secondaries that add the seven flavor medicine material gross weights such as Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae and Cortex Dictamni, each 1-3 hour, merge extractive liquid,, filters, decompression recycling ethanol is also concentrated into thick paste, and vacuum drying obtains ethanol extract.Get medicinal residues after alcohol extraction, add 10 times of water gagings and decoct three times, each 1-3 hour, collecting decoction, it is 1.15～1.20 thick pastes that filtrate decompression is concentrated into relative density, vacuum drying is water extract.
4. add Borneolum Syntheticum jointly to pulverize ethanol extract, water extract, mixing mixes, and crosses 100 mesh sieves, the purified water that adds the seven flavor medicine material gross weight 1-2 such as Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae and Cortex Dictamni doubly to measure, stir, filter, fill obtains Traditional Chinese medicine liniment of the present invention.
The using method that the present invention treats acne papulosa liniment is: during use, be stained with medicinal liquid embrocate affected part or medicinal liquid soak at acne erythra place, every day 2-3 time, 7 days courses for the treatment of with cotton swab.
The present invention brings useful technique effect:
1. prescription of the present invention, through experiment choosing side repeatedly, has accomplished that medication simplifies, and we are only comprised of 8 taste medical materials.
2. to treat acne papulosa Chinese medicine compound be medicine for external use liniment in the present invention, avoided oral drugs to gastral stimulation, and drug safety improves greatly.
3. pharmaceutical preparation of the present invention, preparation method is simple, is easy to store, and is convenient to transportation.
Curative effect of medication of the present invention definite, have no side effect, treating both the principal and secondary aspects of a disease, effective percentage is high, life-time service has protection skin, brightens, the effect of delicate skin.
The specific embodiment
Below the invention will be further described for the description by the specific embodiment, but this is not limitation of the present invention.
Embodiment 1
1. first Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae, Cortex Dictamni are ground into respectively to 20-40 order powder.
2. from powder, take 8 parts of Herba Chelidoniis, 8 parts of Flos Loniceraes, 6 parts of Radix Sophorae Flavescentiss, 6 parts of Cortex Phellodendris, 3 parts of Herba Taraxacis, 6 parts, Flos Sophorae, 4 parts of Cortex Dictamni.
3. 8 times of amount 95% alcohol reflux secondaries that add the seven flavor medicine material gross weights such as Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae and Cortex Dictamni, each 2 hours, merge extractive liquid,, filtered, decompression recycling ethanol is also concentrated into thick paste, and vacuum drying obtains ethanol extract.Get medicinal residues after alcohol extraction, add 10 times of water gagings and decoct three times, each 2 hours, collecting decoction, it is 1.15～1.20 thick pastes that filtrate decompression is concentrated into relative density, vacuum drying is water extract.
4. the Borneolum Syntheticum of ethanol extract, water extract and 0.01 weight portion is pulverized jointly, mixing mixes, cross 100 mesh sieves, the purified water that adds 1 times of amount of seven flavor medicine material gross weight such as Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae and Cortex Dictamni, stir, filter, fill obtains Traditional Chinese medicine liniment of the present invention.
Embodiment 2
1. first Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae, Cortex Dictamni are ground into respectively to 20-40 order powder.
2. from powder, take 9 parts of Herba Chelidoniis, 6 parts of Flos Loniceraes, 6 parts of Radix Sophorae Flavescentiss, 6 parts of Cortex Phellodendris, 6 parts of Herba Taraxacis, 4 parts, Flos Sophorae, 4 parts of Cortex Dictamni, 0.02 part of Borneolum Syntheticum.
3. 8 times of amount 95% alcohol reflux secondaries that add the seven flavor medicine material gross weights such as Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae and Cortex Dictamni, each 2 hours, merge extractive liquid,, filtered, decompression recycling ethanol is also concentrated into thick paste, and vacuum drying obtains ethanol extract.Get medicinal residues after alcohol extraction, add 10 times of water gagings and decoct three times, each 2 hours, collecting decoction, it is 1.15～1.20 thick pastes that filtrate decompression is concentrated into relative density, vacuum drying is water extract.
4. the Borneolum Syntheticum of ethanol extract, water extract and 0.02 weight portion is pulverized jointly, mixing mixes, cross 100 mesh sieves, the purified water that adds 1.5 times of amounts of seven flavor medicine material gross weight such as Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae and Cortex Dictamni, stir, filter, fill obtains Traditional Chinese medicine liniment of the present invention.
Embodiment 3
1. first Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae, Cortex Dictamni are ground into respectively to 20-40 order powder.
2. from powder, take 6 parts of Herba Chelidoniis, 9 parts of Flos Loniceraes, 4 parts of Radix Sophorae Flavescentiss, 4 parts of Cortex Phellodendris, 3 parts of Herba Taraxacis, 6 parts, Flos Sophorae, 6 parts of Cortex Dictamni, 0.01 part of Borneolum Syntheticum.
3. 8 times of amount 95% alcohol reflux secondaries that add the seven flavor medicine material gross weights such as Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae and Cortex Dictamni, each 2 hours, merge extractive liquid,, filtered, decompression recycling ethanol is also concentrated into thick paste, and vacuum drying obtains ethanol extract.Get medicinal residues after alcohol extraction, add 10 times of water gagings and decoct three times, each 2 hours, collecting decoction, it is 1.15～1.20 thick pastes that filtrate decompression is concentrated into relative density, vacuum drying is water extract.
4. the Borneolum Syntheticum of ethanol extract, water extract and 0.01 weight portion is pulverized jointly, mixing mixes, cross 100 mesh sieves, the purified water that adds 1.5 times of amounts of seven flavor medicine material gross weight such as Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae and Cortex Dictamni, stir, filter, fill obtains Traditional Chinese medicine liniment of the present invention.
Embodiment 4
1. first Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae, Cortex Dictamni are ground into respectively to 20-40 order powder.
2. from powder, take 7 parts of Herba Chelidoniis, 9 parts of Flos Loniceraes, 6 parts of Radix Sophorae Flavescentiss, 5 parts of Cortex Phellodendris, 4 parts of Herba Taraxacis, 5 parts, Flos Sophorae, 5 parts of Cortex Dictamni, 0.01 part of Borneolum Syntheticum.
3. 8 times of amount 95% alcohol reflux secondaries that add the seven flavor medicine material gross weights such as Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae and Cortex Dictamni, each 2 hours, merge extractive liquid,, filtered, decompression recycling ethanol is also concentrated into thick paste, and vacuum drying obtains ethanol extract.Get medicinal residues after alcohol extraction, add 10 times of water gagings and decoct three times, each 2 hours, collecting decoction, it is 1.15～1.20 thick pastes that filtrate decompression is concentrated into relative density, vacuum drying is water extract.
4. the Borneolum Syntheticum of ethanol extract, water extract and 0.01 weight portion is pulverized jointly, mixing mixes, cross 100 mesh sieves, the purified water that adds 1.5 times of amounts of seven flavor medicine material gross weight such as Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae and Cortex Dictamni, stir, filter, fill obtains Traditional Chinese medicine liniment of the present invention.
Pharmacodynamic experiment
Clinical observation:
In year May in February, 2012 to 2014, carry out altogether here acne papulosa patient 212 examples of going to a doctor.Age 15-34 year, 20 years old mean age.The course of disease is the longest 5 years, the shortest 6 weeks.Male's 85 examples; Women's 127 examples.Be divided at random two groups for the treatment of groups and matched group, treatment group 162 examples wherein, matched group 50 examples, the there was no significant difference such as two groups of ages, symptom, sex, has comparability.
Treatment group: the liniment treated (according to patient's physical condition, within the scope of the present composition, concrete parts by weight being finely tuned) that adopts medicine of the present invention to make.During use, be stained with medicinal liquid embrocate affected part or medicinal liquid soak at acne erythra place with cotton swab, every day 2 times, each is once sooner or later.
Matched group: adopt compound sulfur lotion for treatment, every day 2 times, sooner or later respectively once.
During all patient's medications, give up alcohol, pungent, greasy product.
Two groups of patients observe treatment two weeks.
Efficacy evaluation:
Cure: pars affecta skin full recovery is normal, and pimple is entirely and disappears;
Effective: pars affecta skin surface pimple disappears more than 85%;
Effective: pars affecta skin surface pimple disappears more than 40% or obviously alleviates;
Invalid: pars affecta skin surface pimple disappear 40% following person or with treat before compare without significant change.
Therapeutic outcome: as shown in table 1.
The contrast of table 1. therapeutic outcome
| Group | Number of cases | Cure (%) | Effective | Effectively | Invalid | Total effective rate |
| Treatment group | 162 | 83 | 53 | 18 | 8 | 95.1％ |
| Matched group | 50 | 8 | 14 | 10 | 18 | 64.0％ |
Inventor stops administration to healing patient and pays a return visit after 1 month, the patient that the present invention cures, and recurrence 3 examples, relapse rate is 3.6%, the patient who cures through compound sulfur lotion, paid a return visit after 1 month, all recurrence.
Claims (6)
1. a treatment acne papulosa Chinese medicine compound, is prepared from by following raw materials according: Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae, Cortex Dictamni and Borneolum Syntheticum.
2. treatment acne papulosa Chinese medicine compound according to claim 1, is characterized in that being prepared from by the raw material of following weight portion:
Herba Chelidonii 6-9 part Flos Lonicerae 6-9 part Radix Sophorae Flavescentis 4-8 part Cortex Phellodendri 4-8 part
Herba Taraxaci 3-6 part Flos Sophorae 4-6 part Cortex Dictamni 4-6 part Borneolum Syntheticum 0.01-0.05 part.
3. treatment acne papulosa Chinese medicine compound according to claim 1, is characterized in that being prepared from by the raw material of following weight portion:
Bend 6 parts of 6 portions of Cortex Phellodendris of 8 parts of Radix Sophorae Flavescentiss of 8 portions of Flos Loniceraes of dish
0.01 part of 4 parts of Borneolum Syntheticum of 6 parts of Cortex Dictamni of 3 parts of Flos Sophoraes of Herba Taraxaci.
4. treatment acne papulosa Chinese medicine compound according to claim 1, is characterized in that being prepared from by the raw material of following weight portion:
6 parts of 6 portions of Cortex Phellodendris of 6 parts of Radix Sophorae Flavescentiss of 9 portions of Flos Loniceraes of Herba Chelidonii
0.02 part of 4 parts of Borneolum Syntheticum of 4 parts of Cortex Dictamni of 6 parts of Flos Sophoraes of Herba Taraxaci.
5. treatment acne papulosa Chinese medicine compound according to claim 1, is characterized in that being prepared from by the raw material of following weight portion:
4 parts of 4 portions of Cortex Phellodendris of 9 parts of Radix Sophorae Flavescentiss of 6 portions of Flos Loniceraes of Herba Chelidonii
0.01 part of 6 parts of Borneolum Syntheticum of 6 parts of Cortex Dictamni of 3 parts of Flos Sophoraes of Herba Taraxaci.
6. according to the preparation method of the treatment acne papulosa Chinese medicine compound external application Chinese medicine liniment described in claim 1-5, it is characterized in that: comprise the steps:
1. first Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae, Cortex Dictamni are ground into respectively to 20-40 order powder.
2. from powder, take Herba Chelidonii 6-9 part, Flos Lonicerae 6-9 part, Radix Sophorae Flavescentis 4-8 part, Cortex Phellodendri 4-8 part, Herba Taraxaci 3-6 part, Flos Sophorae 4-6 part, Cortex Dictamni 4-6 part.
3. 8 times of amount 95% alcohol reflux secondaries that add the seven flavor medicine material gross weights such as Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae and Cortex Dictamni, each 1-3 hour, merge extractive liquid,, filters, decompression recycling ethanol is also concentrated into thick paste, and vacuum drying obtains ethanol extract.Get medicinal residues after alcohol extraction, add 10 times of water gagings and decoct three times, each 1-3 hour, collecting decoction, it is 1.15～1.20 thick pastes that filtrate decompression is concentrated into relative density, vacuum drying is water extract.
4. add Borneolum Syntheticum jointly to pulverize ethanol extract, water extract, mixing mixes, and crosses 100 mesh sieves, the purified water that adds the seven flavor medicine material gross weight 1-2 such as Herba Chelidonii, Flos Lonicerae, Radix Sophorae Flavescentis, Cortex Phellodendri, Herba Taraxaci, Flos Sophorae and Cortex Dictamni doubly to measure, stir, filter, fill obtains Traditional Chinese medicine liniment of the present invention.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105687883A (en) * | 2016-03-02 | 2016-06-22 | 周常 | Medicine composition for removing acne |
| CN106344726A (en) * | 2016-11-11 | 2017-01-25 | 成都悦伦商贸有限公司 | Method for preparing traditional Chinese medicine composition for treating papule type acnes |
| CN106389524A (en) * | 2016-11-11 | 2017-02-15 | 成都悦伦商贸有限公司 | Traditional Chinese medicine composition for treating papulopustular acne |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105687883A (en) * | 2016-03-02 | 2016-06-22 | 周常 | Medicine composition for removing acne |
| CN106344726A (en) * | 2016-11-11 | 2017-01-25 | 成都悦伦商贸有限公司 | Method for preparing traditional Chinese medicine composition for treating papule type acnes |
| CN106389524A (en) * | 2016-11-11 | 2017-02-15 | 成都悦伦商贸有限公司 | Traditional Chinese medicine composition for treating papulopustular acne |
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Application publication date: 20141119 |