CN103041028B - Traditional Chinese medicine composition for treating acne - Google Patents
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Abstract
The invention discloses a traditional Chinese medicine composition for treating acne. The traditional Chinese medicine composition comprises rhizoma coptidis, radix scutellariae, radix rehmanniae, radix angelicae sinensis, radix sophorae flavescentis, cynanchum paniculatum, cortex dictamni, honeysuckle flowers and licorice roots; and the traditional Chinese medicine composition is characterized by comprising the following Chinese medicinal herbs in parts by mass: 5-20 parts of rhizoma coptidis, 5-25 parts of radix scutellariae, 10-30 parts of radix rehmanniae, 8-30 parts of radix angelicae sinensis, 5-30 parts of radix sophorae flavescentis, 5-30 parts of cynanchum paniculatum, 5-25 parts of cortex dictamni, 10-30 parts of honeysuckle flowers, and 5-15 parts of licorice roots. The traditional Chinese medicine composition has the advantages that through the reasonable compatibility of various Chinese medicinal herbs, and by adopting a special formula of a dual-monarch drug, the traditional Chinese medicine composition meets the compatibility requirements of assistant and guide Chinese medicinal herbs, and achieves a good effect that the cure rate is 52.5% and the total effective rate is 92.5% under limited sample conditions. The traditional Chinese medicine composition disclosed by the invention is rigorous and scientific in formula compatibility; and the Chinese medicinal herbs, either monomers or compositions, produce no toxic or side effect under reasonable application conditions, thereby providing a new therapeutic schedule for the exploration of acne treatment.
Description
Technical field
The invention belongs to the traditional field of Chinese herbal medicine technology of China, specially refer to a kind of Chinese medicine composition of Acne treatment.
Background technology
Acne is the obstruction due to cortex glandular tube and pore, causes the skin outflow pilosebaceous chronic inflammatory disease due to smooth.The traditional Chinese medical science is called " acne ", " whelk ", " skin sore ".Total incidence accounts for the 20-24% of population, is especially apt to occur in adolescence men and women, is mainly in the abundant positions of sebaceous gland such as face, chest, back, part has rash to itch and pain, the course of disease is permanent and slowly, the continued several years having, badly influences patient's face and physical and mental health.Doctor trained in Western medicine thinks that its morbidity is main and sex hormone level, sebaceous gland are secreted in a large number, propionibacterium acnes propagation, the factor analysis such as the dyskeratosis of hair follicle cortex gland conduit and inflammation.The traditional Chinese medical science is thought the pathogensis of primary disease: plain body sun heat is contained partially, and lung meridian intrinsic heat, is subject to ailment said due to cold or exposure again, stifling face and sending out; The pungent delicious food savoury of surfeit, helps heat of wetting, damp-heat gluing each other, upper steaming face and causing; Deficiency of spleen-QI, dysfunction of the spleen in transportation and transformation, stops in turbid damp, strongly fragrant heat-transformation of a specified duration, the bright body fluid of heat, decocts and is smelt expectorant, and the wet hot phlegm stasis of blood stagnates skin and sends out.According to this pathogenesis, the present inventor has done research in earnest, and the morbidity of analyzing acne be unable to do without " wetting ", " heat " two large principal elements, and then has proposed goal of the invention of the present invention.
Summary of the invention
Goal of the invention of the present invention is according to above-mentioned pathogenesis of acne mechanism, and according to the theory of Chinese Chinese medicine, it is main drawing up heat clearing and damp drying, holds concurrently with eliminating fire and detoxication, and removing heat from blood and promoting blood circulation dispels the wind and one group of Chinese medicine composition of Acne treatment.A kind of Chinese medicine composition of Acne treatment is provided.
Technical solution of the present invention is to realize like this, the Chinese medicine composition of this Acne treatment, there is Rhizoma Coptidis, Radix Scutellariae, the Radix Rehmanniae, Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Radix Cynanchi Paniculati, Cortex Dictamni, Flos Lonicerae and Radix Glycyrrhizae, it is characterized in that each Chinese medicine material forms according to following mass fraction compatibility
Rhizoma Coptidis 5-20 part, Radix Scutellariae 5-25 part, Radix Rehmanniae 10-30 part, Radix Angelicae Sinensis 8-30 part, Radix Sophorae Flavescentis 5-30 part, Radix Cynanchi Paniculati 5-30 part, Cortex Dictamni 5-25 part, Flos Lonicerae 10-30 part, Radix Glycyrrhizae 5-15 part.
By optimizing, each Chinese medicine material of said Rhizoma Coptidis, Radix Scutellariae, the Radix Rehmanniae, Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Radix Cynanchi Paniculati, Cortex Dictamni, Flos Lonicerae and Radix Glycyrrhizae forms according to following mass fraction compatibility:
Rhizoma Coptidis 10-15 part, Radix Scutellariae 10-20 part, Radix Rehmanniae 10-20 part, Radix Angelicae Sinensis 10-20 part, Radix Sophorae Flavescentis 10-20 part, Radix Cynanchi Paniculati 10-20 part, Cortex Dictamni 10-20 part, Flos Lonicerae 15-20 part, Radix Glycyrrhizae 8-15 part.
Through further optimizing, each Chinese medicine material of said Rhizoma Coptidis, Radix Scutellariae, the Radix Rehmanniae, Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Radix Cynanchi Paniculati, Cortex Dictamni, Flos Lonicerae and Radix Glycyrrhizae forms according to following mass fraction compatibility:
Rhizoma Coptidis 12-15 part, Radix Scutellariae 15-20 part, Radix Rehmanniae 15-20 part, Radix Angelicae Sinensis 15-20 part, Radix Sophorae Flavescentis 15-20 part, Radix Cynanchi Paniculati 15-20 part, Cortex Dictamni 15-20 part, Flos Lonicerae 15-20 part, Radix Glycyrrhizae 10-15 part.
According to Chinese medicine and modern < < Chinese Pharmacopoeia > >, record, above-mentioned all taste Chinese herbal medicine are below described.
Rhizoma Coptidis.Meridian distribution of property and flavor: (root) hardship, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.Usage and dosage: decoction, 2～5 grams.
Radix Scutellariae.Meridian distribution of property and flavor: hardship, cold.Return lung, gallbladder, spleen, stomach, large intestine, small intestine meridian.Function cures mainly: heat clearing and damp drying, and eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.Usage and dosage: 3～9g.
The Radix Rehmanniae.Meridian distribution of property and flavor: sweet, cold.GUIXIN, liver, kidney channel.Function cures mainly: Radix Rehmanniae clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid.Usage and consumption: 9～15 grams.
Radix Angelicae Sinensis.Meridian distribution of property and flavor: sweet in the mouth; Pungent; Bitter; Warm in nature.Return liver, the heart, spleen channel.Function cures mainly: tonifying blood and regulating menstruation; Promoting blood circulation and stopping pain; Loosening bowel to relieve constipation.Usage and dosage: for oral administration: to decoct soup, 6-12 gram; Or enter ball, loose; Or infusing drugs in wine; Or deposited cream.
Radix Sophorae Flavescentis.Meridian distribution of property and flavor: bitter in the mouth; Cold in nature.Return liver, kidney, large intestine, small intestine meridian, heart channel, urinary bladder channel.Function cures mainly: heat clearing and damp drying; Parasite killing (external), diuresis.Usage and dosage: 4.5～9g.
Radix Cynanchi Paniculati.Meridian distribution of property and flavor: pungent, temperature.Return liver, stomach warp.Function cures mainly: the removing dampness of dispeling the wind, antalgesic-antipruritic.Usage and dosage: 3～12g, enter decoct should after under.
Cortex Dictamni.Meridian distribution of property and flavor: hardship; Salty; Cold.Return spleen channel, lung meridian, small intestine meridian, stomach warp, urinary bladder channel.Function cures mainly: heat clearing and damp drying; Dispelling wind for relieving itching; Removing toxic substances.Rubella due to wind heat noxious dampness; Eczema; Scabies; Jaundice; Damp-heat arthralgia.Usage and dosage: for oral administration: to decoct soup, 6-15 gram; Or enter ball, loose.
Flos Lonicerae.Meridian distribution of property and flavor: sweet, micro-hardship, delicate fragrance, pungent, cold.Return lung, stomach, the heart, large intestine channel.Function cures mainly: dispelling wind-heat, heat-clearing and toxic substances removing.Consumption: 10～30 grams of crude drugs; Fry 10～20 grams of medicines; 10～15 grams of charcoal drugs.
Radix Glycyrrhizae.Meridian distribution of property and flavor: sweet in the mouth, property is flat, nontoxic.Return 12 warps.Function cures mainly: have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic be so that the pharmacological action such as anticancer.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Usage and dosage: 1.5～9g.
In said medicine combination, Rhizoma Coptidis, Radix Scutellariae are monarch drug altogether, and the two is the property of bitter cold, kind middle burnt stomach-fire, the clear damp-heat in middle-JIAO of rushing down of Rhizoma Coptidis, Radix Scutellariae rushes down part of the body cavity above the diaphragm housing the heart and lungs lung-fire, clearing away lung-heat partially, Rhizoma Coptidis and Radix Scutellariae, similar temperament and respectively have speciality, therefore two medicine synergism and the damp and hot benefit in Qinghua is aobvious.Flos Lonicerae heat-clearing and toxic substances removing, wind-dispelling heat-dissipating are ministerial drug.Radix Sophorae Flavescentis heat clearing and damp drying, Radix Rehmanniae clearing away heat and cooling blood, Chinese Angelica blood replonishing is invigorated blood circulation, and it is adjuvant drug altogether that Radix Cynanchi Paniculati, Cortex Dictamni go wind antipruritic.Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is for making medicine.Harmoniously, the effect of play altogether heat clearing and damp drying, eliminating fire and detoxication, removing heat from blood and promoting blood circulation, dispeling the wind, all has good result for the acne of various pattern of syndrome in full side.
Useful technique effect of the present invention is the reasonable compatibility through all taste Chinese herbal medicine, adopt the special formula of two monarchs drug, meet the Chinese medicine compatibility requirement of monarch, under limited sample condition, obtained cure rate 52.5%, total effective rate reaches 92.5% good result.Prescription compatibility rigorous and scientific of the present invention, all Chinese herbal medicine materials are monomer or prescription no matter, and the generation that all has no side effect under rational service condition, for Acne treatment has been explored a new therapeutic scheme.
The specific embodiment
The embodiment that provides concrete quality composition below, the present invention is described in detail.Following amount is daily dose, one pair of every day.
Embodiment 1
Get: 5 grams of Rhizoma Coptidis, 5 grams of Radix Scutellariaes, 10 grams, the Radix Rehmanniae, 8 grams of Radix Angelicae Sinensis, 5 grams of Radix Sophorae Flavescentiss, 5 grams of Radix Cynanchi Paniculatis, 5 grams of Cortex Dictamni, 10 grams of Flos Loniceraes, 5 grams, Radix Glycyrrhizae.Sooner or later each is once decocted in water for oral dose.
Embodiment 2
Get: 20 grams of Rhizoma Coptidis, 25 grams of Radix Scutellariaes, 30 grams, the Radix Rehmanniae, 30 grams of Radix Angelicae Sinensis, 30 grams of Radix Sophorae Flavescentiss, 30 grams of Radix Cynanchi Paniculatis, 25 grams of Cortex Dictamni, 30 grams of Flos Loniceraes, 15 grams, Radix Glycyrrhizae.Sooner or later each is once decocted in water for oral dose.
Embodiment 3
10 grams of Rhizoma Coptidis, 10 grams of Radix Scutellariaes, 15 grams, the Radix Rehmanniae, 15 grams of Radix Angelicae Sinensis, 10 grams of Radix Sophorae Flavescentiss, 10 grams of Radix Cynanchi Paniculatis, 10 grams of Cortex Dictamni, 15 grams of Flos Loniceraes, 8 grams, Radix Glycyrrhizae.Sooner or later each is once decocted in water for oral dose.
Embodiment 4
12 grams of Rhizoma Coptidis, 15 grams of Radix Scutellariaes, 20 grams, the Radix Rehmanniae, 20 grams of Radix Angelicae Sinensis, 15 grams of Radix Sophorae Flavescentiss, 15 grams of Radix Cynanchi Paniculatis, 15 grams of Cortex Dictamni, 20 grams of Flos Loniceraes, 10 grams, Radix Glycyrrhizae.Sooner or later each is once decocted in water for oral dose.
Embodiment 5
15 grams of Rhizoma Coptidis, 20 grams of Radix Scutellariaes, 25 grams, the Radix Rehmanniae, 25 grams of Radix Angelicae Sinensis, 20 grams of Radix Sophorae Flavescentiss, 20 grams of Radix Cynanchi Paniculatis, 20 grams of Cortex Dictamni, 25 grams of Flos Loniceraes, 12 grams, Radix Glycyrrhizae.Sooner or later each is once decocted in water for oral dose.
Embodiment 6
15 grams of Rhizoma Coptidis, 20 grams of Radix Scutellariaes, 20 grams, the Radix Rehmanniae, 20 grams of Radix Angelicae Sinensis, 20 grams of Radix Sophorae Flavescentiss, 20 grams of Radix Cynanchi Paniculatis, 20 grams of Cortex Dictamni, 20 grams of Flos Loniceraes, 10 grams, Radix Glycyrrhizae.Sooner or later each is once decocted in water for oral dose.
Decocting method is as follows: above-mentioned all taste Chinese herbal medicine are placed in decoction pot, add clear water 500-600 milliliter, soak 30-60 minute, then decoction pot is placed in to the upper boiled 3-5 of boiling minute of first big fire of fire, then little fire keeps fluidized state in decoction pot, 20-30 minute, makes pot interior clear water and Chinese herbal medicine through decocting and be mixed into medicine soup fully.Treat that in decoction pot, medicine soup amount is 150-200 milliliter, medicine soup is poured out.To in decoction pot, pour the water of 500-600 milliliter into again, repeat aforesaid process.After the medicine soup of twice decoction is mixed, take at twice.
Therapeutic effect:
In People's Republic of China's Chinese medicine industry standard (ZY/T001-94):
Eight, in TCM Dermatology disease Standardization of diagnosis and curative effect:
The diagnosis basis of 41 acne, syndrome-classification, efficacy evaluation.
Acne are mainly in face, take pimple, pustule, tuberosity sometimes can extrude the white a kind of dermatosis that sample powder juice is feature of cracking rice.Be equivalent to acne vulgaris.
41.1 diagnosis basis.
41.1.1 from the beginning of at follicular orifice, present the red pimple of small rice grain size, also can develop into pustule.After this can form scleroma sample hoary hair's acne or blackhead, serious case can form scleroma property cyst.
41.1.2 be mainly in face and the chest and back of men and women's adolescence, often with seborrhea.
41.1.3 have eating and drinking without temperance more, surfeit delicious food savoury, or sense exopathogen etc. brings out.
41.1.4 after adolescence, majority can alleviate naturally.
41.1.5 women is many with menoxenia.
41.2 syndrome-classifications.
41.2.1 wind and heat in the lung meridian: pimple color is red, or have the pain of itching.Red tongue, yellow and thin fur, floating and rapid pulse.
41.2.2 damp-heat accumulation: erythra congestion and swelling pain, or have pustule, halitosis, constipation, yellowish urine.Red tongue, yellow and greasy fur, slippery and rapid pulse.
41.2.3 phlegm-damp condenses: erythra is formed cyst, or have indigestion and loss of appetite, loose stool.Light red tongue is fat, thin fur, rolling pulse.
41.3 efficacy evaluations.
41.3.1 cure: skin lesion is disappeared, subjective symptoms disappears.
41.3.2 take a turn for the better: subjective symptoms obviously alleviates, and skin lesion disappears more than 30%.
41.3.3 do not heal: skin lesion and symptom be the unchanged or less than 30% that disappears all.
According to afore mentioned rules requirement, from 2010 01 month in December, 2012, patient diagnosis Acne treatment patient 120 people, age 13-28 year, wherein man: 78 people, female: 42 people.Adopt the prescription of Chinese medicine composition of the present invention, one pair of every day, be sooner or later decocted in water for oral dose at twice, 7 days courses for the treatment of.Through the treatment of 3 courses for the treatment of, cure 63 people, 48 people that take a turn for the better, 9 people of not healing.Cure rate 52.5%, total effective rate reaches 92.5%, and invalid 7.5%.
In 120 people, lung meridian wind-heat type 40 people, damp-heat accumulation type 40 people, phlegm-damp condensation type 40 people, all adopt Chinese medicine composition prescription of the present invention.Drug regimen formula has been broken syndrome boundary, has been taken into account the characteristics of incidence of each pattern of syndrome, has realized specific prescription for certain illness, and has obtained satisfied clinical efficacy.
Prescription of the present invention institute consumption is higher compared with the recommendation of the documents such as Chinese Pharmacopoeia, its reason, and the one,, the patient of acne is youngster mostly, and this disease is because savoury is rich etc., reason causes; The 2nd,, current Chinese herbal medicine is mostly artificial culture, and its drug effect and genuine degree are all to some extent not as traditional wild Chinese herbal medicine.So the more general patient of consumption in prescription and the consumption of literature recommendation are large, this is also confirmed by practice.Large consumption in employing side, has obtained good therapeutic effect.
In order to adapt to various different patients' needs, the Chinese medicine composition of this prescription can be made the dosage forms such as loose, ball, capsule or granule according to the regulation of Chinese Pharmacopoeia, to facilitate, takes and applies.
Claims (3)
1. a Chinese medicine composition for Acne treatment, has Rhizoma Coptidis, Radix Scutellariae, the Radix Rehmanniae, Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Radix Cynanchi Paniculati, Cortex Dictamni, Flos Lonicerae and Radix Glycyrrhizae, it is characterized in that each Chinese medicine material forms according to following mass fraction compatibility:
Rhizoma Coptidis 5-20 part, Radix Scutellariae 5-25 part, Radix Rehmanniae 10-30 part, Radix Angelicae Sinensis 8-30 part, Radix Sophorae Flavescentis 5-30 part, Radix Cynanchi Paniculati 5-30 part, Cortex Dictamni 5-25 part, Flos Lonicerae 10-30 part, Radix Glycyrrhizae 5-15 part.
2. according to the Chinese medicine composition of a kind of Acne treatment claimed in claim 1, it is characterized in that each Chinese medicine material of said Rhizoma Coptidis, Radix Scutellariae, the Radix Rehmanniae, Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Radix Cynanchi Paniculati, Cortex Dictamni, Flos Lonicerae and Radix Glycyrrhizae forms according to following mass fraction compatibility:
Rhizoma Coptidis 10-15 part, Radix Scutellariae 10-20 part, Radix Rehmanniae 10-20 part, Radix Angelicae Sinensis 10-20 part, Radix Sophorae Flavescentis 10-20 part, Radix Cynanchi Paniculati 10-20 part, Cortex Dictamni 10-20 part, Flos Lonicerae 15-20 part, Radix Glycyrrhizae 8-15 part.
3. according to the Chinese medicine composition of a kind of Acne treatment claimed in claim 1, it is characterized in that each Chinese medicine material of said Rhizoma Coptidis, Radix Scutellariae, the Radix Rehmanniae, Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Radix Cynanchi Paniculati, Cortex Dictamni, Flos Lonicerae and Radix Glycyrrhizae forms according to following mass fraction compatibility:
Rhizoma Coptidis 12-15 part, Radix Scutellariae 15-20 part, Radix Rehmanniae 15-20 part, Radix Angelicae Sinensis 15-20 part, Radix Sophorae Flavescentis 15-20 part, Radix Cynanchi Paniculati 15-20 part, Cortex Dictamni 15-20 part, Flos Lonicerae 15-20 part, Radix Glycyrrhizae 10-15 part.
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