CN100462101C - Medicament for treating aplastic anemia - Google Patents
Medicament for treating aplastic anemia Download PDFInfo
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- CN100462101C CN100462101C CNB2006101282759A CN200610128275A CN100462101C CN 100462101 C CN100462101 C CN 100462101C CN B2006101282759 A CNB2006101282759 A CN B2006101282759A CN 200610128275 A CN200610128275 A CN 200610128275A CN 100462101 C CN100462101 C CN 100462101C
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- rhizoma
- aplastic anemia
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Abstract
The invention discloses a medicament for treating regenerative anemia which is prepared from Chinese herbs of ginseng, cow-bezoar, pulp of dogwood fruit, polygala root, banksia rose, prepared rhizome of rehmannia, white atractylodes rhizome, licorice root, astragalus root, poria cocos, Chinese caterpillar fungus, cimicifuga rhizome, spine date seed, hairy deerhorn, longan pulp, Chinese angelica root, poria with hostwood, Cinnamomum cassia, slice of aconite, schisandra fruit, dried ginger, root of red rooted saliva and motherwort.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of medicine for the treatment of aplastic anemia.
Background technology
Aplastic anemia sickness rate in recent years is higher, aplastic anemia is called for short aplastic anemia, be obviously to reduce owing to multiple reason causes the bone marrow hematogenesis tissue, the depletion of bone marrow hematogenesis function, classical symptom is: carrying out property anemia, hemorrhage, infect and pancytopenia, on the traditional Chinese medical science, belong to " chronic consumptive disease; disorders of blood " category, cause the chemistry that is generally of this disease, treatment, factors such as infection, it is white that primary disease often shows yellowish complexion, health is weak, severe palpitation, it is dizzy to be easy to flu, part patient has heating paresthesia, and heating easily repeatedly, skin has the petechia, pale tongue, white and thin fur, deep-thready pulse or count accurately also has some patients to merge gingival infection, the anorectal inflammation, throat is dried itches etc.The main feature of hemogram is a pancytopenia during aplastic anemia, the hemoglobin of chronic aplastic anemia is many about 50 grams per liters, numeration of leukocyte is about 2000/ cubic millimeter, neutrophilic granulocyte also reduces, mostly about 25%, and accounting for percentage ratio, increases in lymphocyte, platelet can reduce to 1 ten thousand-2 ten thousand/cubic millimeter, and reticulocyte is normal〉the pancytopenia degree of 1% acute aplastic anemia is more serious, and hemoglobin can be reduced to about 30 grams per liters, leukocyte is reduced to about 1000/ cubic millimeter, neutrophilic granulocyte extremely reduces can be less to 10%, and platelet can be less than 10000/ cubic millimeter, and reticulocyte reduces, often be lower than 1%, even be 0%.Patient's condition danger, more the back is undesirable, and is generally dead in half a year to one year.Doctor trained in Western medicine mainly contains the following aspects to the treatment of aplastic anemia: A: androgen; B: immunosuppressive therapy: as ciclosporin A, ATG, heavy dose of prednisolone, heavy dose of third ball etc.; C: microcirculation improvement is as 654-2 etc.; The choice drug of chronic aplastic anemia treatment is " androgen ", it stimulates cell hemopoietic under the bone marrow, to chronic aplastic anemia curative effect preferably, total effective rate is about 70%-80%, but androgen treatment chronic aplastic anemia comes into force slowly, no matter inject or oral, at least want about two months ability first meeting curative effect, part patient's curative effect occurs more late, generally continuous treatment 6 months nonresponder still, just be considered to invalid and abandon, so will adhere to treating continuously half a year at least androgen, and the hormone therapy side effect is bigger, and medical expense is very high.
Summary of the invention
The medicine that the purpose of this invention is to provide a kind of short treating period, effective treatment aplastic anemia.
The present invention realizes above-mentioned purpose by the following technical solutions: a kind of medicine for the treatment of aplastic anemia, mainly make by the raw material of following parts by weight:
Red, each 10~25 Calculus Boviss, 2~5 Fructus Corni 10~25 of Radix Ginseng
Radix Polygalae 6~10 Radix Aucklandiae 5~10 dried Radix Rehmanniaes Preparata 20~40
The Rhizoma Atractylodis Macrocephalae 25~40 Radix Glycyrrhizaes 6~10 Radixs Astragali 15~35
Poria 10~20 Cordyceps 6~10 Rhizoma Cimicifugaes 8~25
Semen Ziziphi Spinosae 6~15 Cornu Cervi Pantotrichums 5~20 Arillus Longans 15~40
Radix Angelicae Sinensis 20~50 Poria cum Radix Pinis 6~15 Cortex Cinnamomis 8~20
RADIX ACONITI LATERALIS PREPARATA 8~20 Fructus Schisandrae Chinensis 10~20 Rhizoma Zingiberiss 5~15
Radix Salviae Miltiorrhizae 8~20 Herba Leonuris 13~20
Also add following parts by weight raw material arranged:
Rhizoma Dioscoreae 10~15 Os Draconis 6~15 Concha Ostreaes 6~15
Radix Bupleuri 3~10 Massa Medicata Fermentata 5~15 Fructus Hordei Germinatus 5~15
Caulis Spatholobi 8~20
A kind of medicine for the treatment of aplastic anemia, preferably make by following parts by weight raw material:
Red, each 10~20 Calculus Boviss, 3~5 Fructus Corni 10~20 of Radix Ginseng
Radix Polygalae 6~8 Radix Aucklandiae 5~8 dried Radix Rehmanniaes Preparata 20~30
The Rhizoma Atractylodis Macrocephalae 25~30 Radix Glycyrrhizaes 6~8 Radixs Astragali 15~30
Poria 10~15 Cordyceps 6~8 Rhizoma Cimicifugaes 8~15
Semen Ziziphi Spinosae 6~10 Cornu Cervi Pantotrichums 5~18 Arillus Longans 15~30
Radix Angelicae Sinensis 20~40 Poria cum Radix Pinis 6~10 Cortex Cinnamomis 8~15
RADIX ACONITI LATERALIS PREPARATA 8~15 Fructus Schisandrae Chinensis 10~15 Rhizoma Zingiberiss 5~10
Radix Salviae Miltiorrhizae 8~15 Herba Leonuris 13~18 Rhizoma Dioscoreaes 10~13
Os Draconis 6~10 Concha Ostreaes 6~10 Radix Bupleuri 3~6
Massa Medicata Fermentata 5~10 Fructus Hordei Germinatus 5~10 Caulis Spatholobis 8~15
A kind of medicine for the treatment of aplastic anemia, most preferably make by the raw material of following parts by weight:
Red, each 25 Calculus Boviss, 5 Fructus Corni 25 of Radix Ginseng
Radix Polygalae 10 Radix Aucklandiae 10 dried Radix Rehmanniaes Preparata 40
The Rhizoma Atractylodis Macrocephalae 40 Radix Glycyrrhizaes 10 Radixs Astragali 35
Poria 20 Cordyceps 10 Rhizoma Cimicifugaes 25
Semen Ziziphi Spinosae 15 Cornu Cervi Pantotrichums 20 Arillus Longans 40
Radix Angelicae Sinensis 50 Poria cum Radix Pinis 15 Cortex Cinnamomis 20
RADIX ACONITI LATERALIS PREPARATA 20 Fructus Schisandrae Chinensis 20 Rhizoma Zingiberiss 15
Radix Salviae Miltiorrhizae 20 Herba Leonuris 20 Rhizoma Dioscoreaes 15
Os Draconis 15 Concha Ostreaes 15 Radix Bupleuri 10
Massa Medicata Fermentata 15 Fructus Hordei Germinatus 15 Caulis Spatholobis 20
Above crude drug is concocted according to following method:
1, Radix Polygalae, Radix Glycyrrhizae, the Radix Astragali, the little fire of Rhizoma Cimicifugae are made popular, add the little fire of Mel and fry 15 minutes, and big fire is received and done.
2, Rhizoma Dioscoreae, the Rhizoma Atractylodis Macrocephalae, Semen Ziziphi Spinosae, Fructus Hordei Germinatus, Massa Medicata Fermentata, Fructus Schisandrae Chinensis, Rhizoma Zingiberis parching to brown Jiao.
3, Os Draconis, Concha Ostreae are fried and burn till redness.
4, Radix Bupleuri is made popular, fries with rice vinegar and does.
5, fry the dried powder of beating in the Radix Rehmanniae Preparata aluminum pot.
6, Radix Angelicae Sinensis is chosen the Radix Angelicae Sinensis body.
Above raw material can be made into mixture, pill, capsule or tablet.
1, oral liquid: each component drug decocts together, concentrates, and is distributed into fractional pack, a 10ml, and three times on the one, taking medicine before meal usefulness changes one after each meal into if any the diarrhoea situation.
2, pill: raw material is pulverizing respectively, makes honeyed pill according to the ratio adding Mel of 1:1~1.7, about each honeyed pill 9g; Take one time 1~2 ball, three times on the one.
3, capsule: the material medicine pulverizing, incapsulate, one time 2~4, three times on the one.
Among the present invention; after crude drug is concocted; red; Radix Ginseng's QI invigorating helps hemopoietic; contain multivitamin; glucose etc.; Radix Rehmanniae Preparata; Cortex Cinnamomi; Fructus Corni; Arillus Longan; the Radix Angelicae Sinensis body; Cornu Cervi Pantotrichum; Cordyceps; Rhizoma dioscoreae (parched) promotes the bone marrow spermatogenesis; hemopoietic; enrich blood and lubricated not dry; can prevent Cornu Cervi Pantotrichum; Radix Ginseng; Cordyceps; Rhizoma Zingiberis Preparatum; Radix Aconiti Lateralis Preparata is mended and is given birth to hot; scorching hemorrhage; also contain abundant ferrum; potassium; zinc; mineral such as calcium; the Rhizoma Atractylodis Macrocephalae; Radix Glycyrrhizae Preparata; Radix Astragali Preparata; Fructus Schisandrae Chinensis; Semen Ziziphi Spinosae; Radix Polygalae; Poria; Poria cum Radix Pini; Radix Aconiti Lateralis Preparata; Rhizoma Zingiberis Preparatum; Rhizoma Cimicifugae; Radix Bupleuri; forge Os Draconis; forge Concha Ostreae and play spleen invigorating altogether; ascending up spleen-Qi and Yang; astringent or styptic treatment for spontaneous sweating kidney qi; wherein Rhizoma Cimicifugae is that specifically functional medicine is arranged simply; leukocytic medicine can improve patient's white blood cell count if it cooperates liter; cooperate the erythrocytic medicine of liter can improve patient's erythrocyte quantity; cooperate the medicine of hemopoietic platelet to also have the effect of thrombocytosis in addition; Radix Salviae Miltiorrhizae; Caulis Spatholobi; Herba Leonuri; Massa Medicata Fermentata; Fructus Hordei Germinatus; the Radix Aucklandiae; Calculus Bovis is played activating blood and promoting diuresis altogether; the appetizing feed; prevented the trouble of greasy stomach; Calculus Bovis has the merit of cephalocathartic detoxifcation; protect from infection; help red; leukocytic generation; make meridians unblocked, help the absorption and the stop of other drug.Medicine of the present invention is with strong points, therapeutic effect good, short treating period.
The specific embodiment
Embodiment, following table is enumerated 6 embodiments of the invention, raw material in the following example is made corresponding dosage forms take for the patient.
Component | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 |
Red Radix Ginseng | Each is 10 years old | Each is 15 years old | Each is 20 years old | Each is 25 years old | Each is 22 years old | Each is 25 years old | Each is 12 years old | Each is 18 years old | Each is 20 years old | Each is 15 years old |
Calculus Bovis | 5 | 3 | 2 | 4 | 5 | 5 | 3 | 4 | 2 | 3 |
Fructus Corni | 15 | 10 | 20 | 25 | 22 | 25 | 12 | 18 | 20 | 22 |
Radix Polygalae | 6 | 8 | 7 | 9 | 10 | 10 | 7 | 8 | 9 | 6 |
The Radix Aucklandiae | 5 | 6 | 10 | 8 | 9 | 8 | 5 | 6 | 10 | 7 |
Dried Radix Rehmanniae Preparata | 20 | 25 | 40 | 30 | 35 | 40 | 22 | 28 | 32 | 38 |
The Rhizoma Atractylodis Macrocephalae | 40 | 25 | 30 | 35 | 27 | 40 | 28 | 32 | 38 | 26 |
Radix Glycyrrhizae | 6 | 8 | 10 | 9 | 7 | 10 | 8 | 6 | 7 | 9 |
The Radix Astragali | 30 | 15 | 25 | 35 | 20 | 35 | 16 | 18 | 28 | 32 |
Poria | 20 | 10 | 15 | 17 | 13 | 20 | 10 | 18 | 16 | 12 |
Cordyceps | 6 | 8 | 7 | 10 | 9 | 10 | 9 | 6 | 8 | 7 |
Rhizoma Cimicifugae | 8 | 15 | 20 | 25 | 17 | 25 | 9 | 12 | 18 | 22 |
Semen Ziziphi Spinosae | 6 | 10 | 8 | 15 | 12 | 15 | 9 | 12 | 8 | 14 |
Cornu Cervi Pantotrichum | 5 | 18 | 15 | 10 | 20 | 20 | 6 | 9 | 12 | 16 |
Arillus Longan | 30 | 40 | 20 | 15 | 25 | 40 | 18 | 22 | 28 | 38 |
Radix Angelicae Sinensis (body) | 20 | 50 | 30 | 40 | 35 | 38 | 22 | 48 | 42 | 32 |
Poria cum Radix Pini | 6 | 10 | 8 | 15 | 12 | 15 | 6 | 7 | 9 | 12 |
Cortex Cinnamomi | 8 | 15 | 12 | 20 | 18 | 20 | 18 | 10 | 16 | 9 |
RADIX ACONITI LATERALIS PREPARATA | 18 | 15 | 8 | 20 | 13 | 20 | 9 | 12 | 10 | 16 |
Fructus Schisandrae Chinensis | 10 | 13 | 15 | 20 | 17 | 20 | 12 | 16 | 18 | 19 |
Rhizoma Zingiberis | 8 | 5 | 10 | 15 | 12 | 15 | 6 | 8 | 9 | 14 |
Radix Salviae Miltiorrhizae | 20 | 15 | 8 | 12 | 17 | 20 | 9 | 10 | 18 | 13 |
Herba Leonuri | 20 | 13 | 15 | 18 | 17 | 18 | 14 | 16 | 19 | 20 |
Rhizoma Dioscoreae | 10 | 0 | 12 | 15 | 13 | 0 | 0 | 0 | 10 | 12 |
Os Draconis | 15 | 0 | 10 | 6 | 12 | 0 | 0 | 0 | 8 | 13 |
Concha Ostreae | 10 | 0 | 15 | 12 | 6 | 0 | 0 | 0 | 8 | 13 |
Radix Bupleuri | 3 | 0 | 10 | 6 | 8 | 0 | 0 | 0 | 5 | 9 |
Massa Medicata Fermentata | 5 | 0 | 12 | 15 | 10 | 0 | 0 | 0 | 8 | 13 |
Fructus Hordei Germinatus | 5 | 0 | 10 | 15 | 12 | 0 | 0 | 0 | 8 | 13 |
Caulis Spatholobi | 15 | 0 | 20 | 8 | 10 | 0 | 0 | 0 | 12 | 18 |
Medicine of the present invention is through 12 routine clinical experiments, acute aplastic anemia 8 examples wherein, chronic aplastic anemia 4 examples, take medicine of the present invention, 15 days courses of treatment, oral medicine of the present invention is after 3 courses of treatment, inquire and follow up a case by regular visits to the doorstep through phone, all patients' symptom all is significantly improved or cures.
Therapeutic outcome sees the following form:
Case | Cure | Produce effects | Effectively |
Acute aplastic anemia | 1 | 4 | 3 |
Chronic aplastic anemia | 0 | 2 | 2 |
Case 1: Shao, man, the village people of Lingbao City Kawaguchi, through the People's Hospital, Lingbao City, Sanmenxia City the Yellow River hospital is diagnosed as " pure red property aplastic anemia anemia ", and is not obvious through treating, treat on April 12nd, 2003, patient's complexion HUANGBAI(sic) at that time, whole body swelling, abdominal discomfort and expanding, defecate immediately after the food, suffer from diarrhea every day 3~4 times, feel run-down, appetite is poor, light red tongue, tongue are greasy in vain, deep and weak pulse, leukocyte 2500/mm
3, hematochrome 5g/mm
3Treatment: take medicine of the present invention, 15 days, swelling was moved back slightly, after up in consumption add and subtract slightly, adhered to taking 65 days, swelling is disappeared, and wherein chemically examines leukocyte 2900/mm on May 3
3, hematochrome 6g/mm
3, again through treatment in 50 days, all transference cures, mental restoration is as usual.
Case 2: Wang, man, the Yin Zhuan of Lingbao City people from town, once in the People's Hospital, Lingbao City, Sanmenxia City the Yellow River hospital, the affiliated hospitalize of Xi'an hematopathy study on prevention, three tame hospitals are diagnosed as acute aplastic anemia, on JIUYUE 17th, 2003, treat, this patient's complete blood cell is low, dizzy, nervous, cardiopalmus, palpitation with a distress feeling, anorexia, agitation, with swelling and aching of gum pain, mouthful difficult opening, anus is itched, leukocyte 2000/mm
3, hematochrome 3.5g/mm
3Treatment: take medicine of the present invention, October 16 is to the chemical examination of the People's Hospital, Lingbao City, leukocyte 3700/mm
3, hematochrome 4.2g/mm
3, to continue to take medicine, November 18 chemically examined again, leukocyte 4500/mm
3, hematochrome 5.3g/mm
3Dizzy, nervous, cardio palmus shape disappears, and it is normal that diet recovers.
Case 3: Lee, man, 11 years old, be diagnosed as chronic aplastic anemia through how tame hospital, on March 12nd, 2006 treated, and inspection is learnt, this patient's yellowish complexion is white, weak all over, sends out low grade fever, the permanent current nose bleeding, treatment: take medicine of the present invention, epistaxis reduces after 3~5 days, nose is no longer hemorrhage after 10 days, after March, spirit takes a turn for the better, and is strong on one's body.
Claims (5)
1. a medicine for the treatment of aplastic anemia is characterized in that, is mainly made by the raw material of following parts by weight:
Red, each 10~25 Calculus Boviss, 2~5 Fructus Corni 10~25 of Radix Ginseng
Radix Polygalae 6~10 Radix Aucklandiae 5~10 dried Radix Rehmanniaes Preparata 20~40
The Rhizoma Atractylodis Macrocephalae 25~40 Radix Glycyrrhizaes 6~10 Radixs Astragali 15~35
Poria 10~20 Cordyceps 6~10 Rhizoma Cimicifugaes 8~25
Semen Ziziphi Spinosae 6~15 Cornu Cervi Pantotrichums 5~20 Arillus Longans 15~40
Radix Angelicae Sinensis 20~50 Poria cum Radix Pinis 6~15 Cortex Cinnamomis 8~20
RADIX ACONITI LATERALIS PREPARATA 8~20 Fructus Schisandrae Chinensis 10~20 Rhizoma Zingiberiss 5~15
Radix Salviae Miltiorrhizae 8~20 Herba Leonuris 13~20.
2. the medicine of treatment aplastic anemia as claimed in claim 1 is characterized in that, also adding has following parts by weight raw material:
Rhizoma Dioscoreae 10~15 Os Draconis 6~15 Concha Ostreaes 6~15
Radix Bupleuri 3~10 Massa Medicata Fermentata 5~15 Fructus Hordei Germinatus 5~15
Caulis Spatholobi 8~20.
3. the medicine of treatment aplastic anemia as claimed in claim 2 is characterized in that, is made by following parts by weight raw material:
Red, each 10~20 Calculus Boviss, 3~5 Fructus Corni 10~20 of Radix Ginseng
Radix Polygalae 6~8 Radix Aucklandiae 5~8 dried Radix Rehmanniaes Preparata 20~30
The Rhizoma Atractylodis Macrocephalae 25~30 Radix Glycyrrhizaes 6~8 Radixs Astragali 15~30
Poria 10~15 Cordyceps 6~8 Rhizoma Cimicifugaes 8~15
Semen Ziziphi Spinosae 6~10 Cornu Cervi Pantotrichums 5~18 Arillus Longans 15~30
Radix Angelicae Sinensis 20~40 Poria cum Radix Pinis 6~10 Cortex Cinnamomis 8~15
RADIX ACONITI LATERALIS PREPARATA 8~15 Fructus Schisandrae Chinensis 10~15 Rhizoma Zingiberiss 5~10
Radix Salviae Miltiorrhizae 8~15 Herba Leonuris 13~18 Rhizoma Dioscoreaes 10~13
Os Draconis 6~10 Concha Ostreaes 6~10 Radix Bupleuri 3~6
Massa Medicata Fermentata 5~10 Fructus Hordei Germinatus 5~10 Caulis Spatholobis 8~15.
4. the medicine of treatment aplastic anemia as claimed in claim 2 is characterized in that, is made by the raw material of following parts by weight:
Red, each 25 Calculus Boviss, 5 Fructus Corni 25 of Radix Ginseng
Radix Polygalae 10 Radix Aucklandiae 10 dried Radix Rehmanniaes Preparata 40
The Rhizoma Atractylodis Macrocephalae 40 Radix Glycyrrhizaes 10 Radixs Astragali 35
Poria 20 Cordyceps 10 Rhizoma Cimicifugaes 25
Semen Ziziphi Spinosae 15 Cornu Cervi Pantotrichums 20 Arillus Longans 40
Radix Angelicae Sinensis 50 Poria cum Radix Pinis 15 Cortex Cinnamomis 20
RADIX ACONITI LATERALIS PREPARATA 20 Fructus Schisandrae Chinensis 20 Rhizoma Zingiberiss 15
Radix Salviae Miltiorrhizae 20 Herba Leonuris 20 Rhizoma Dioscoreaes 15
Os Draconis 15 Concha Ostreaes 15 Radix Bupleuri 10
Massa Medicata Fermentata 15 Fructus Hordei Germinatus 15 Caulis Spatholobis 20.
5. as the medicine of any described treatment aplastic anemia of claim 1~4, it is characterized in that above raw material is made mixture, pill, capsule or tablet.
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CNB2006101282759A CN100462101C (en) | 2006-11-24 | 2006-11-24 | Medicament for treating aplastic anemia |
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CNB2006101282759A CN100462101C (en) | 2006-11-24 | 2006-11-24 | Medicament for treating aplastic anemia |
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CN100462101C true CN100462101C (en) | 2009-02-18 |
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Families Citing this family (6)
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CN102727709B (en) * | 2012-05-31 | 2014-03-26 | 固镇县中医院 | Chinese herbal pill for treating spleen deficiency type thrombocytopenia |
CN102727748B (en) * | 2012-05-31 | 2013-10-09 | 刘敏 | Traditional Chinese medicine composition for treating aplastic anemia by nourishing qi and yin |
CN102727765B (en) * | 2012-05-31 | 2013-10-09 | 刘敏 | Internally-used medicine for treating aplastic anemia by nourishing yin and yang |
CN102961554B (en) * | 2012-11-14 | 2014-02-26 | 凤台县中医院 | Traditional Chinese medicine composition for treating uterine prolapse |
CN103028086B (en) * | 2012-12-20 | 2014-06-04 | 周瑾 | Traditional Chinese medicine pill for treating iron deficiency anemia |
CN103386071A (en) * | 2013-07-08 | 2013-11-13 | 周明千 | A Chinese herbal medicine combination for treating leukemia |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1051504A (en) * | 1989-11-04 | 1991-05-22 | 姜振轩 | The compound method and the technology of regeneration powder |
CN1271590A (en) * | 1999-04-22 | 2000-11-01 | 李国峰 | Medical capsule for curing aplastic anemia and its preparing process |
CN1080564C (en) * | 1995-09-15 | 2002-03-13 | 仇殿明 | Medicine for treatment of aplastic anemia and its preparation method |
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2006
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1051504A (en) * | 1989-11-04 | 1991-05-22 | 姜振轩 | The compound method and the technology of regeneration powder |
CN1080564C (en) * | 1995-09-15 | 2002-03-13 | 仇殿明 | Medicine for treatment of aplastic anemia and its preparation method |
CN1271590A (en) * | 1999-04-22 | 2000-11-01 | 李国峰 | Medical capsule for curing aplastic anemia and its preparing process |
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