CN111388564B - Traditional Chinese medicine for treating bradyarrhythmia - Google Patents
Traditional Chinese medicine for treating bradyarrhythmia Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Abstract
The invention relates to a traditional Chinese medicine composition for treating bradyarrhythmia. The medicament is prepared from the following Chinese medicinal raw materials in parts by weight: 18-22 parts of red ginseng, 14-16 parts of bran-fried bighead atractylodes rhizome, 18-22 parts of epimedium herb, 18-22 parts of fructus psoraleae, 28-32 parts of cornu cervi degelatinatum, 18-22 parts of salvia miltiorrhiza, 28-32 parts of cassia twig, 14-16 parts of prepared rehmannia root, 5-7 parts of pseudo-ginseng, 18-22 parts of astragalus membranaceus and 14-16 parts of rhizoma nardostachyos. The traditional Chinese medicine composition has the effects of warming yang, tonifying qi, removing blood stasis and dredging stagnation, can effectively and radically treat bradyarrhythmia, can treat both symptoms and root causes, has long-term and definite curative effect, is safe to use, and is worthy of popularization and application.
Description
Technical Field
The invention relates to a traditional Chinese medicine for treating bradyarrhythmia.
Background
Chronic arrhythmia is a disease with cardiac frequency lower than normal value, and generally has the symptoms of occult disease, mild patients can cause organ insufficient blood supply, and severe patients can cause serious circulatory disturbance to endanger life. At present, western medicine treatment is limited, and atropine, isoproterenol, alpha and beta receptor agonists and the like are adopted for common drug treatment. The western medicines are easy to relapse after stopping taking the medicine, and side effects such as secondary tachyarrhythmia, intolerance and the like are easy to generate. The cardiac pacemaker can be used as a radical treatment method for an indication patient, but the cardiac pacemaker is expensive, has a plurality of risks for invasive treatment and limits the clinical universal application. With the continuous development of the traditional Chinese medicine industry, the adoption of the traditional Chinese medicine for treating the slow arrhythmia is a good choice for patients who do not tolerate western medicines and refuse to install pacemakers. The traditional Chinese medicine treatment focuses on strengthening the body resistance and consolidating the constitution, treats both principal and secondary aspect of diseases, has low price, small toxic and side effects and reliable long-term curative effect, and has few recrudescence once cured.
The slow arrhythmia belongs to the categories of palpitation, severe palpitation and the like in traditional Chinese medicine, at present, compound traditional Chinese medicines are mostly limited to medicaments such as ephedra herb, asarum herb, monkshood and the like which warm and dredge heart yang, the medicaments are slightly divergent and shallow in walking, the heart yang is easy to dissipate in the process of activating the heart yang, even if the heart rate is improved, the effect can be obtained only for one time, the conduction block is difficult to dredge, the recurrence rate is high, and the long-term curative effect is insufficient. At present, the urgent need is to explore a traditional Chinese medicine composition which has long-term curative effect and can effectively and radically cure bradyarrhythmia.
Disclosure of Invention
The invention aims to provide the traditional Chinese medicine for treating the bradyarrhythmia, which can effectively radically treat the bradyarrhythmia, can treat both principal and secondary aspects of the bradyarrhythmia, has long and definite curative effect and safe use, is worthy of popularization and application, and is a safe and effective traditional Chinese medicine preparation.
The technical scheme of the invention is as follows:
the invention relates to a traditional Chinese medicine for treating bradyarrhythmia, which is a medicament prepared from the following traditional Chinese medicine raw materials in parts by weight:
18-22 parts of red ginseng; 14-16 parts of bran-fried bighead atractylodes rhizome; 18-22 parts of epimedium; 18-22 parts of fructus psoraleae; 28-32 parts of cornu cervi degelatinatum; 18-22 parts of salvia miltiorrhiza; 28-32 parts of cassia twig; 14-16 parts of prepared rehmannia root; 5-7 parts of pseudo-ginseng; 18-22 parts of astragalus; 14-16 parts of rhizoma nardostachyos.
The preparation method comprises the following steps:
the first step is as follows: weighing the Chinese herbal medicine raw materials according to the corresponding proportion of the prescription, mixing half of the total amount of the red ginseng and the cornu cervi degelatinatum according to the weight parts and the pseudo-ginseng, and crushing the mixture into powder A with the fineness of 24 meshes; the second step: mixing the rest red ginseng and cornu cervi degelatinatum with the rest eight Chinese herbal medicines such as the red sage root and the like, adding water, decocting for two times, namely 2.5 hours for the first time and 2 hours for the second time, then merging the decoctions, filtering, and concentrating the filtrate into clear paste B with the density of 1.10-1.20 g/mL; the third step: mixing the powder A prepared in the first step and the fluid extract B prepared in the second step, drying, crushing into powder with the fineness of 80 meshes, adding starch accounting for 8-15% of the total weight, mixing uniformly, sieving with a 80-mesh sieve, and encapsulating. The filling amount of each capsule is 0.5g.
The usage and dosage are as follows:
the capsule preparation is 0.5g per capsule. Orally administered 5 granules once for adult, 3 times daily; the preparation is administered 3 times a day for children under 16 years old. Taken before meals or following the doctor's advice.
The invention has the beneficial effects that:
the preparation is prepared from red ginseng, pseudo-ginseng, salvia miltiorrhiza, fructus psoraleae, epimedium, cornu cervi degelatinatum, cassia twig, astragalus mongholicus, fried bighead atractylodes rhizome, nardostachys chinensis, prepared rehmannia root and the like, has the functions of warming yang, tonifying qi, removing blood stasis and relieving stagnation, is mainly applied to patients with thoracic obstruction, severe palpitation symptoms such as yang-qi deficiency and heart vessel blockage, and is clinically commonly seen in various bradyarrhythmias caused by myocarditis and coronary heart disease. The preparation of the invention is mainly used for treating the diseases, and can effectively increase heart rate and improve myocardial conduction besides effectively relieving clinical symptoms. The pathogenesis of the bradyarrhythmia is concerned with the deficiency of three yang of heart, spleen and kidney and blood stasis as the target. The preparation of the invention adopts the principle of tonifying the heart, spleen and kidney by three yang together and the rule of reducing phlegm and removing stagnancy as the auxiliary. Compared with the prior art, the traditional Chinese medicine has the following effects: the heart, the spleen and the kidney tonify the three yang simultaneously, and the blood stasis is removed and the stagnation is removed, so that the medicines are used together to strengthen the body resistance, clear the source and treat both the principal and secondary aspects simultaneously, thereby enabling the heart pulse to be vigorous, active and rooted and achieving the purpose of treating the bradyarrhythmia.
The traditional Chinese medicine of the invention has the formula:
in the formula of the traditional Chinese medicine composition, the cassia twig is pungent and sweet in taste and warm in nature, enters heart, lung and bladder channels, and has the effects of sweating, expelling muscles, warming and dredging channels, supporting yang, regulating qi and calming the pulse; the epimedium herb is pungent and sweet in flavor and warm in nature, enters liver and kidney channels, and has the effects of tonifying kidney yang, strengthening muscles and bones and dispelling wind-damp; cornu Cervi Degelatinatum is salty and astringent, has warm nature, enters liver and kidney channels, and has effects of warming kidney, tonifying yang, astringing and stopping bleeding; the red ginseng is sweet in taste, slightly bitter in taste and warm in nature, has the functions of invigorating primordial qi, recovering pulse, relieving depletion, benefiting qi and controlling blood, and has the functions of invigorating spleen, lung, heart and kidney; the astragalus root is sweet in taste and slightly warm in nature, enters lung and spleen channels, and has the effects of tonifying qi and raising yang, consolidating superficial resistance and arresting sweating, inducing diuresis and reducing edema, promoting fluid production and nourishing blood, removing stagnation and removing obstruction of qi, expelling pus, healing sore and promoting granulation. The Chinese medicinal cassia twig warms and clears heart yang; herba Epimedii and cornu Cervi Degelatinatum can warm and tonify kidney yang; red ginseng and Astragalus root, radix Ginseng Rubra are the monarch drugs for warming and activating spleen yang.
In the formula of the traditional Chinese medicine composition, the bran-fried bighead atractylodes rhizome is bitter and sweet in taste and warm in nature, enters spleen and stomach channels, and has the effects of strengthening spleen and tonifying qi, eliminating dampness and promoting diuresis, suppressing sweating and preventing miscarriage. The psoralea fruit is pungent and bitter in taste and warm in nature, enters kidney and spleen channels, and has the effects of warming kidney and tonifying yang, absorbing qi and relieving asthma, and warming spleen and stopping diarrhea. The traditional Chinese medicines of the white atractylodes rhizome fried with bran and the fructus psoraleae are used as ministerial medicines and can help monarch medicines to warm and tonify kidney yang and warm and transport spleen yang.
In the formula of the traditional Chinese medicine composition, the nardostachys root and rhizome is pungent and sweet in taste and warm in nature, enters spleen and stomach channels, and has the effects of regulating qi, relieving pain, relieving depression and activating spleen. Prepared rehmannia root, radix rehmanniae Praeparata is sweet in taste and slightly warm in nature, enters liver and kidney meridians, and has the effects of enriching blood and nourishing yin, and replenishing vital essence and marrow. The traditional Chinese medicine rhizoma nardostachyos has the effects of regulating qi and tonifying without stagnation; prepared rehmannia root, radix rehmanniae Praeparata has the effects of nourishing blood and nourishing yin, and can be used as an adjuvant drug for preventing yang-tonifying drugs from being too warm and dry and for seeking yang from yin.
In the formula of the traditional Chinese medicine composition, the salvia miltiorrhiza is bitter in taste and slightly cold in nature, and has the effects of invigorating blood circulation, removing blood stasis, stimulating the menstrual flow, relieving pain, clearing away the heart-fire, relieving restlessness, cooling blood and eliminating carbuncle, and the salvia miltiorrhiza enters heart and liver channels; notoginseng radix is sweet in taste, slightly bitter in nature, warm in nature, and enters liver and stomach meridians, and has effects of removing blood stasis, stopping bleeding, and relieving swelling and pain. The salvia miltiorrhiza and the pseudo-ginseng activate blood circulation to remove meridian obstruction, and promote qi and blood circulation under the action of a large amount of warm tonifying medicines, and are used as guiding medicines.
The medicines are combined to supplement three yang of heart yang, spleen yang and kidney yang, so that blood stasis is transformed, the original is corrected, the source is cleared, and the principal and secondary aspects are treated simultaneously, thereby achieving good clinical curative effect.
The preparation is prepared from red ginseng, pseudo-ginseng, salvia miltiorrhiza, fructus psoraleae, epimedium, cornu cervi degelatinatum, cassia twig, astragalus membranaceus, fried bighead atractylodes rhizome, nardostachys chinensis, prepared rehmannia root and the like, has the functions of warming yang, tonifying qi, dispersing blood stasis and relieving stagnation, is mainly applied to patients suffering from obstruction of qi in the chest, severe palpitation due to yang deficiency and heart vessel obstruction, and is clinically commonly seen in various chronic arrhythmias caused by myocarditis and coronary heart disease. The preparation of the invention is mainly used for treating the diseases, and can effectively increase heart rate and improve myocardial conduction besides effectively relieving clinical symptoms. The pathogenesis of the bradyarrhythmia is concerned with the deficiency of three yang of heart, spleen and kidney and blood stasis as the target. The preparation of the invention adopts the principle of tonifying the heart, spleen and kidney by three yang together and the rule of reducing phlegm and removing stagnancy as the auxiliary.
The following is a summary of some clinical data of the invention
Various chronic arrhythmia is caused by myocarditis and coronary heart disease, and clinically, symptoms such as yang-qi deficiency, heart-vessel blockage type chest stuffiness, severe palpitation and the like are often presented. The traditional Chinese medicine composition disclosed by the invention is mainly used for treating the diseases, and not only can effectively relieve clinical symptoms, but also can effectively increase heart rate and improve conduction of cardiac muscle. The fact proves that the traditional Chinese medicine composition has definite curative effect and safe use when being used for treating the thoracic obstruction and the severe palpitation which belong to the patients with yang-qi deficiency and heart vessel obstruction, and is a safe and effective traditional Chinese medicine capsule preparation worthy of popularization and application.
1. General data of patient
Of 100 patients, 60 men (60%), 40 women (40%); age 17-63 years, mean (34 ± 11.2) years; the disease course is 8 months to 10 years, the average disease course (2.2 +/-1.3) years, wherein 28 cases within 1 year, 46 cases within 1 to 5 years and 26 cases above 5 years are included; the medication time is 25 to 75 days, and the average medication time (41 +/-12.4) days.
2. Analysis of clinical efficacy
The traditional Chinese medicine is a traditional Chinese medicine composition for treating chronic rhythms, which is provided by the inventor through a large number of clinical tests and researches; the traditional Chinese medicine composition has the effects of increasing heart rate, improving myocardial conduction and the like, can adjust disordered immune function of a patient, and can enhance physique of the patient, so that symptoms of chest impediment, severe palpitation and the like of the patient are obviously improved, the condition of the patient is effectively controlled, and the purpose of treating the patient fundamentally is achieved.
In clinical treatment of all patients, the effective rate for improving the average heart rate is 71.5%, the effective rate for improving the conduction block is 90.3%, and the total effective rate for sick sinus syndrome is 77%.
Analysis of clinical efficacy (number of cases,%)
| Observation index | Number of examples | Show effect | Is effective | Invalidation | Total effective rate |
| Average heart rate | 56 | 24(42.9%) | 16(28.6%) | 16(28.6%) | 42(71.5%) |
| Conduction block | 31 | 16(51.6%) | 12(38.7%) | 3(9.7%) | 94(90.3%) |
| Sick sinus syndrome | 13 | 6(46.2%) | 4(30.8%) | 3(23.1%) | 38(77.0%) |
The effect is shown: the average ventricular rate increase is more than or equal to 10 times/min, the symptoms disappear, and the electrocardiogram is basically normal;
the method has the following advantages: the ventricular rate is averagely increased by more than or equal to 6 times/min, the symptoms are improved, and the electrocardiogram is improved;
and (4) invalidation: the ventricular rate increased averagely <6 times/min, and no improvement or deterioration of symptoms and electrocardiogram occurred.
3. Analysis of usage
The clinical application of 100 patients is that the average daily dosage is 15 granules, the minimum dosage is 9 granules, and the maximum dosage is 18 granules; the average use time is 41 days, the shortest use time is 25 days, and the longest use time is 75 days; the total dose is 920 granules on average, 170 granules are used at minimum, and 1820 granules are used at maximum.
Analysis of usage
| Item | Mean number | Standard deviation of | Minimum number of | Maximum number of | Median number |
| Daily dose (granule) | 15 | 3 | 12 | 18 | 16 |
| Service time (sky) | 41 | 12.4 | 25 | 75 | 76 |
| Dosage (granule) | 920 | 82.5 | 172 | 1820 | 980 |
4. Clinical application safety analysis
In the clinical application process, people always pay attention to safety observation, patients have no adverse reactions such as systemic anaphylactic reaction and the like, and other safety problems are not found through literature retrieval.
5. To summarize:
the pathogenesis of the bradyarrhythmia is that the heart, spleen and kidney are deficient in three yang and blood stasis is the target. The traditional Chinese medicine composition mainly adopts the principle of simultaneous tonifying of three yang of heart, spleen and kidney and the principle of reducing phlegm and removing stagnation, has the functions of warming yang and tonifying qi, and removing blood stasis and removing stagnation, is mainly applied to patients with thoracic obstruction and severe palpitation which belong to yang-qi deficiency and heart vessel blockage, and is clinically commonly seen in various chronic arrhythmias caused by myocarditis and coronary heart disease. The traditional Chinese medicine composition can effectively relieve clinical symptoms, and can also effectively increase heart rate and improve myocardial conduction. The fact proves that the traditional Chinese medicine composition has definite curative effect on the chest impediment and severe palpitation patients with yang-qi deficiency and heart vessel obstruction, is safe to use and is worth popularizing.
Typical cases are:
zhang Yi, woman, age 53, teacher. For intermittent palpitation for more than 1 month, the doctor should be treated in 4 months in 2019. The symptoms are palpitation, chest distress, dizziness, hypodynamia, insomnia, poor appetite, dark tongue, white and greasy fur and slow pulse. Physical examination: the heart rate is 50 times/minute, the rhythm is irregular, and the auscultation areas of the valves do not smell and obviously produce noise. And (3) checking electrocardiogram display: 1. sinus rhythm; 2. type II atrioventricular block. Combined with patient symptoms, impressions: and (3) Western diagnosis: bradyarrhythmia; traditional Chinese medicine diagnosis: palpitation, heart yang deficiency. After the capsule of the invention is orally taken, 5 capsules are taken each time, three times a day, and the capsule is continuously applied for 60 days, the main clinical symptoms disappear, and the electrocardiogram is recovered to be normal.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto.
Example 1
The invention relates to a traditional Chinese medicine for treating bradyarrhythmia, which is a medicament prepared from the following traditional Chinese medicine raw materials in parts by weight:
18 g of red ginseng; 14 g of white atractylodes rhizome stir-fried with bran; 18 g of epimedium; 18 g of fructus psoraleae; 28 g of cornu cervi degelatinatum; 18 g of salvia miltiorrhiza; 28 g of cassia twig; prepared rehmannia root, radix rehmanniae 14 g; 5g of pseudo-ginseng; 18 g of astragalus; 14 g of nard.
The preparation method comprises the following steps:
the first step is as follows: weighing the Chinese herbal medicine raw materials according to the corresponding proportion, mixing half of the total amount of the red ginseng and the cornu cervi degelatinatum and the pseudo-ginseng according to the parts by weight, and crushing the mixture into powder A with the fineness of 24 meshes; the second step is that: mixing the rest red ginseng and cornu cervi degelatinatum with the rest eight Chinese herbal medicines such as the red sage root and the like, adding water, decocting for two times, namely 2.5 hours for the first time and 2 hours for the second time, then merging the decoctions, filtering, and concentrating the filtrate into clear paste B with the density of 1.10-1.20 g/mL; the third step: mixing the powder A prepared in the first step and the fluid extract B prepared in the second step, oven drying, pulverizing into 80 mesh powder, adding starch 10 wt%, mixing, sieving with 80 mesh sieve, and making into capsule. The filling amount of each capsule is 0.5g.
Example 2
The invention relates to a traditional Chinese medicine for treating bradyarrhythmia, which is a medicament prepared from the following traditional Chinese medicine raw materials in parts by weight:
20g of red ginseng; 15 g of white atractylodes rhizome fried with bran; 21 g of epimedium; psoralea fruit 20 g; 30 g of cornu cervi degelatinatum; 21 g of salvia miltiorrhiza; 30 g of cassia twig; prepared rehmannia root 15 g; 6 g of pseudo-ginseng; 20g of astragalus; 15 g of nard.
The preparation method comprises the following steps:
the first step is as follows: weighing the Chinese herbal medicine raw materials according to corresponding proportions, mixing half of the total amount of red ginseng and cornu cervi degelatinatum and pseudo-ginseng according to parts by weight, and crushing to prepare powder A with the fineness of 24 meshes; the second step: mixing the rest red ginseng and cornu cervi degelatinatum with the rest eight Chinese herbal medicines such as the red sage root and the like, adding water, decocting for two times, namely 2.5 hours for the first time and 2 hours for the second time, then merging the decoctions, filtering, and concentrating the filtrate to obtain clear paste B with the density of 1.10-1.20 g/mL; the third step: mixing the powder A prepared in the first step and the fluid extract B prepared in the second step, oven drying, pulverizing into 80 mesh powder, adding starch 12 wt%, mixing, sieving with 80 mesh sieve, and making into capsule. The filling amount of each capsule is 0.5g.
Example 3
The invention relates to a traditional Chinese medicine for treating bradyarrhythmia, which is a medicament prepared from the following traditional Chinese medicine raw materials in parts by weight:
21 g of red ginseng; 16 g of white atractylodes rhizome fried with bran; 22 g of epimedium; 22 g of fructus psoraleae; 32 g of cornu cervi degelatinatum; 22 g of salvia miltiorrhiza; 32 g of cassia twig; prepared rehmannia root, radix rehmanniae Preparata 16 g; 7 g of pseudo-ginseng; 22 g of astragalus; 16 g of nard.
The preparation method comprises the following steps:
the first step is as follows: weighing the Chinese herbal medicine raw materials according to corresponding proportion, mixing half of the total amount of the red ginseng and the cornu cervi degelatinatum and the pseudo-ginseng according to the weight part, and crushing to prepare powder A with the fineness of 24 meshes; the second step is that: mixing the rest red ginseng and cornu cervi degelatinatum with the rest eight Chinese herbal medicines such as the red sage root and the like, adding water, decocting for two times, namely 2.5 hours for the first time and 2 hours for the second time, then merging the decoctions, filtering, and concentrating the filtrate into clear paste B with the density of 1.10-1.20 g/mL; the third step: mixing the powder A prepared in the first step and the fluid extract B prepared in the second step, oven drying, pulverizing into 80 mesh powder, adding 14 wt% starch, mixing, sieving with 80 mesh sieve, and making into capsule. The filling amount of each capsule is 0.5g.
Claims (1)
1. A traditional Chinese medicine for treating bradyarrhythmia is a medicament prepared from the following traditional Chinese medicine raw materials in parts by weight:
18-22 parts of red ginseng; 14-16 parts of bran-fried bighead atractylodes rhizome; 18-22 parts of epimedium; 18-22 parts of fructus psoraleae; 28-32 parts of cornu cervi degelatinatum; 18-22 parts of salvia miltiorrhiza; 28-32 parts of cassia twig; 14-16 parts of prepared rehmannia root; 5-7 parts of pseudo-ginseng; 18-22 parts of astragalus; 14-16 parts of rhizoma nardostachyos;
the preparation method of the traditional Chinese medicine for treating the bradyarrhythmia comprises the following steps:
the first step is as follows: weighing the Chinese herbal medicine raw materials according to the corresponding proportion of the prescription, mixing half of the total amount of the red ginseng and the cornu cervi degelatinatum according to the weight parts and the pseudo-ginseng, and crushing the mixture into powder A with the fineness of 24 meshes;
the second step is that: mixing the rest red ginseng and cornu cervi degelatinatum with the rest eight Chinese herbal medicines such as the red sage root and the like, adding water, decocting for two times, namely 2.5 hours for the first time and 2 hours for the second time, then merging the decoctions, filtering, and concentrating the filtrate into clear paste B with the density of 1.10-1.20 g/mL;
the third step: mixing the powder A prepared in the first step and the fluid extract B prepared in the second step, drying, crushing into powder with the fineness of 80 meshes, adding starch accounting for 8-15% of the total weight, mixing uniformly, sieving with an 80-mesh sieve, and encapsulating, wherein the filling amount of each capsule is 0.5g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| 三阳同补治疗缓慢性心律失常50例临床观察;齐建兴等;《中国中医药信息杂志》;20050930;第12卷(第9期);78-79 * |
| 温阳通滞对可乐定造成大鼠缓慢性心律失常的影响;齐建兴;《中国中医药现代远程教育》;20140831;第12卷(第16期);157-159 * |
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