CN115089663B - Traditional Chinese medicine composition with qi-tonifying and body fluid-generating effects and preparation method thereof - Google Patents
Traditional Chinese medicine composition with qi-tonifying and body fluid-generating effects and preparation method thereof Download PDFInfo
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- CN115089663B CN115089663B CN202210780693.5A CN202210780693A CN115089663B CN 115089663 B CN115089663 B CN 115089663B CN 202210780693 A CN202210780693 A CN 202210780693A CN 115089663 B CN115089663 B CN 115089663B
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Abstract
The application discloses a traditional Chinese medicine composition with the effects of tonifying qi and promoting the production of body fluid and a preparation method thereof, wherein the composition comprises the following components in parts by weight: 10-40 parts of radix glehniae, 10-40 parts of dwarf lilyturf tuber, 10-40 parts of dendrobium, 20-60 parts of Chinese yam, 10-40 parts of kudzuvine root, 5-20 parts of ginseng, 20-60 parts of astragalus mongholicus, 10-40 parts of schisandra chinensis, 10-40 parts of white paeony root, 10-30 parts of platycodon grandiflorum, 10-30 parts of burdock, 10-30 parts of figwort root, 10-30 parts of glossy privet fruit, 10-30 parts of eclipta, 4-15 parts of cassia twig and 5-10 parts of liquorice. The composition can effectively solve the problem of poor treatment effect on qi and yin fluid impairment symptoms of patients after radiotherapy in the existing traditional Chinese medicine composition.
Description
Technical Field
The application relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition with qi-tonifying and fluid-generating effects and a preparation method thereof.
Background
Malignant tumors are the second leading cause of death of urban and rural residents in China at present, and have risen to the first in partial urban areas. Radiotherapy is one of the important methods for treating malignant tumors, and a plurality of tumors take the treatment method as a main therapy, so that the curative effect is definite, and toxic and side effects of radiotherapy comprise reaction of local irradiation parts, systemic reaction and local reaction; modern medical research proves that radioactive rays can ionize organisms and destroy cells and tissues which are damaged normally, and different symptoms and signs are presented according to different irradiation parts; the general reaction is manifested as thirst, dry throat, dry tongue, dry stool, yellow urine, pale complexion, dizziness, listlessness, spontaneous perspiration, night sweat, debilitation, anorexia, palpitation, insomnia, and other symptoms. For these toxic and side effects of radiotherapy, patients often cannot tolerate them, and not only the quality of life is affected, but also the total radiation dose has to be reduced and the treatment is interrupted, so that the curative effect is seriously affected, and an effective method is required to be found in clinic, so that the contradiction is solved.
According to the theory of traditional Chinese medicine, the radiation line is fire heat toxin pathogen, and is most prone to consuming qi and damaging fluid, so that clinically patients are prone to fatigue, dizziness, low voice, inappetence, dry mouth, dry throat, sore throat, dry stool, red tongue with little coating or pale tongue with white coating, weak pulse and other symptoms of qi-yin deficiency and fluid-deficiency, and from the aspect of pathogenesis, the traditional unified view is that the traditional Chinese medicine is a recipe composition for treating qi-tonifying yin-nourishing and heat-clearing and detoxifying by consuming qi and damaging yin (fluid), qi-yin (fluid) deficiency. However, the existing medicaments for tonifying qi, nourishing yin, clearing heat and detoxicating have poor treatment effect after radiotherapy through effect judgment.
Disclosure of Invention
Aiming at the defects in the prior art, the application provides a traditional Chinese medicine composition with the effects of tonifying qi and promoting the production of body fluid, and the composition can effectively solve the problem that the traditional Chinese medicine composition has poor treatment effect on qi-yin-fluid impairment symptoms of patients after radiotherapy.
In order to achieve the above purpose, the technical scheme adopted by the application for solving the technical problems is as follows:
a traditional Chinese medicine composition with the effects of tonifying qi and promoting the production of body fluid comprises the following components in parts by weight: 10-40 parts of radix glehniae, 10-40 parts of dwarf lilyturf tuber, 10-40 parts of dendrobium, 20-60 parts of Chinese yam, 10-40 parts of kudzuvine root, 5-20 parts of ginseng, 20-60 parts of astragalus mongholicus, 10-40 parts of schisandra chinensis, 10-40 parts of white paeony root, 10-30 parts of platycodon grandiflorum, 10-30 parts of burdock, 10-30 parts of figwort root, 10-30 parts of glossy privet fruit, 10-30 parts of eclipta, 4-15 parts of cassia twig and 5-10 parts of liquorice.
Further, the composition comprises the following components in parts by weight: 20-30 parts of radix glehniae, 15-20 parts of dwarf lilyturf tuber, 15-30 parts of dendrobium, 30-50 parts of Chinese yam, 15-30 parts of kudzuvine root, 10-15 parts of ginseng, 30-50 parts of astragalus mongholicus, 15-20 parts of schisandra chinensis, 15-30 parts of white paeony root, 15-20 parts of platycodon grandiflorum, 15-20 parts of burdock, 15-20 parts of figwort root, 15-20 parts of glossy privet fruit, 15-20 parts of eclipta, 6-12 parts of cassia twig and 6-9 parts of liquorice.
Further, 25 parts of radix glehniae, 20 parts of dwarf lilyturf tuber, 25 parts of dendrobium, 40 parts of Chinese yam, 25 parts of kudzuvine root, 15 parts of ginseng, 40 parts of astragalus root, 20 parts of Chinese magnoliavine fruit, 25 parts of white paeony root, 20 parts of platycodon root, 20 parts of great burdock achene, 20 parts of figwort root, 20 parts of glossy privet fruit, 20 parts of eclipta, 12 parts of cassia twig and 8 parts of liquorice.
In the scheme, the glehnia root has sweet and slightly bitter taste, is slightly cold in nature and tends to settle, has the effects of nourishing yin and clearing heat, tonifying stomach and promoting fluid production, can nourish yin of lung and stomach, clear lung and stomach heat, is a good medicine for treating yin impairment of lung and stomach or dryness heat impairment of body fluid, and the glehnia root is selected to nourish yin and clear lung, tonify stomach and promote fluid production, so that the lung is not impaired by dryness heat, thereby playing the roles of dispersing and descending, dredging and regulating water channels, regulating systemic water delivery and metabolism, quenching thirst and promoting fluid production;
radix Ophiopogonis is sweet and slightly bitter in taste and slightly cold in nature, and enters heart, lung and stomach meridians; has the effects of nourishing yin and promoting fluid production, moistening lung and clearing heart, is better for nourishing lung and stomach yin and producing body fluid, is used for treating little body fluid and thirst due to lung and stomach yin deficiency, can clear heart and relieve restlessness, and can produce blood due to calm, and can also be used for dissolving body fluid due to the same source of body fluid and blood, and the recipe uses dwarf lilyturf tuber, has sweet and cold taste, is a Gan Liang yin-supplementing top-grade product, and is combined with glehnia root, nourishing yin and promoting fluid production, and assisting the effect of dwarf lilyturf tuber in nourishing yin.
Dendrobium nobile is sweet and slightly cold, nourishes the body, enters stomach and kidney meridians, is a good product of stomach yin deficiency, clears deficiency heat, takes the property of dendrobe sweet and nourished gently, nourishes stomach yin, nourishes kidney yin, generates body fluid, withdraws deficiency heat, kidney governs water, kidney yang is qi-transforming into a good degree, spleen governs transportation and transformation, and transmits body fluid generated by kidney to lung, so that lung distributes the whole body to quench thirst.
Pueraria root, radix Puerariae, gan Xinliang, tends to rise and float, promote the production of body fluid to quench thirst and raise yang to stop diarrhea, on one hand, the effect of the radix Puerariae on clearing heat and promoting the production of body fluid to quench thirst is taken, so that body fluid is not damaged by heat evil, and on the other hand, the effect of the radix Puerariae on encouraging qi rising of spleen and stomach to promote the rising of yang is taken, so that body fluid can bear, and symptoms such as dry mouth and thirst are relieved.
White peony root, radix Paeoniae alba, bitter in flavor, sour in taste, slightly cold in nature, can astringe acid, enter liver meridian, benefit yin and blood of liver, and also soften liver and alleviate pain. Liver qi regulates liver qi to promote liver qi to dredge blood and body fluids, nourish blood and promote fluid production, and white peony root can nourish yin;
the schisandra fruit has sour and astringent taste, sweet and tonifying taste, can astringe and tonify lung qi, nourish kidney yin, tonify qi, strengthen superficies, astringe lung and stop sweat, nourish yin and promote the production of body fluid, prevent body fluid from being dispersed, and enable body fluid to be biochemically active, so that the Chinese magnoliavine fruit is "open source and throttled";
the ginseng and the astragalus root can tonify primordial qi greatly, so-called healthy qi can not be dried, and qi can promote the production of body fluid, promote the circulation of body fluid and take over the body fluid, and healthy qi can promote the production of body fluid, so that body fluid can be normally distributed and excreted, and body fluid is not lost without any cause;
chinese yam is sweet and flat, enters spleen, lung and kidney meridians, and can nourish yin of spleen, lung and kidney, astringe and stop diarrhea, astringe essence and stop leukorrhagia, tonify qi yin, not heat and not dry, tonify but not greasy. The recipe takes the actions of tonifying but not greasy of Chinese yam, tonifying qi and yin, and tonifying both lung, spleen and kidney together with ren Shen and Huang Qi as the mutual action.
Radix scrophulariae, radix Glycyrrhizae, radix Et rhizoma Rhei, radix Angelicae sinensis, and radix Angelicae sinensis, have effects of clearing heat, cooling blood, nourishing yin, reducing pathogenic fire, removing toxic substances, and resolving hard mass, and can be used for treating late stage of disease, yin deficiency, heat generation, and thirst, preventing body fluid from being damaged by heat, and can be used for treating menorrhagia, and can be used for removing shaped nodule.
The radiation and chemotherapy is easy to hurt yin of human body, and has the functions of liver and kidney deficiency, yin deficiency and fire excess, and glossy privet fruit in the recipe, sweet and bitter, and liver and kidney meridian entering, liver and kidney nourishing; ecliptae herba, cold in nature, sweet and sour in taste, and capable of nourishing yin of liver and kidney by tonifying kidney meridian and liver meridian, nourishing liver and kidney, and both Ecliptae herba and fructus Ligustri Lucidi are compatible, so that yin fluid is a biochemical source;
radix Platycodi and fructus Arctii have effects of relieving sore throat and inducing resuscitation, and most patients with radiotherapy and chemotherapy have symptoms of laryngopharynx disorder, hoarseness and swelling and pain, etc., and the two are paired to promote fluid flow and induce resuscitation and relieve sore throat.
Ramulus Cinnamomi warms yang and transforms qi, and is added with yang-warming herbs in order to care yang qi, prevent excessive yin nourishing and hurt yang, and mutually interact yin and yang, and yin is used for yang in yin, so yin is used for yang assistance and biochemical infinite.
Licorice root, radix Glycyrrhizae is cool in nature and can clear heat and detoxify, and most of the recipe is astringent and tonic, and Licorice root, radix Glycyrrhizae can regulate the properties of various drugs;
the preparation method of the traditional Chinese medicine composition with the effects of tonifying qi and promoting the production of body fluid comprises the steps of decocting or pulverizing the above medicines for taking.
Further, the operation method of decoction comprises the following steps: soaking the above materials in cold water for 20-50min, boiling with strong fire, decocting with slow fire for 10-20min, filtering, collecting filtrate, decocting with water twice, filtering, and mixing all filtrates.
Further, the powdering operation method comprises the following steps: pulverizing the above materials, and sieving with 100-120 mesh sieve to obtain fine powder.
The beneficial effects of the application are as follows:
the Chinese medicinal composition takes the sand in the formula of dwarf lilyturf tuber and dendrobium as monarch drugs, and has the effects of nourishing yin, moistening dryness, clearing lung, quenching thirst, benefiting stomach and promoting fluid production; radix scrophulariae, radix puerariae, radix paeoniae alba and schisandra chinensis are ministerial drugs, and are used for cooling blood, nourishing yin, detoxifying, astringing yin and promoting fluid production; eclipta, glossy privet fruit, chinese yam, ginseng, astragalus root, platycodon root, great burdock achene and cassia twig are used as adjuvants, and the effects of tonifying qi and yin, nourishing liver and kidney, inducing resuscitation, relieving sore throat and warming yang to promote qi are achieved; glycyrrhrizae radix is used as guiding drug and harmonizes the drugs. The recipe has the effects of nourishing yin, promoting the production of body fluid, moistening dryness, tonifying qi, detoxifying and relieving sore throat.
Detailed Description
Example 1
A traditional Chinese medicine composition with the effects of tonifying qi and promoting the production of body fluid comprises the following components in parts by weight: 15 parts of radix glehniae, 15 parts of dwarf lilyturf tuber, 20 parts of dendrobium, 25 parts of Chinese yam, 15 parts of kudzuvine root, 10 parts of ginseng, 25 parts of astragalus root, 15 parts of shizandra berry, 15 parts of white paeony root, 15 parts of platycodon root, 15 parts of burdock, 15 parts of figwort root, 15 parts of glossy privet fruit, 15 parts of eclipta, 6 parts of cassia twig and 6 parts of liquorice.
Example 2
A traditional Chinese medicine composition with the effects of tonifying qi and promoting the production of body fluid comprises the following components in parts by weight: 30 parts of radix glehniae, 30 parts of dwarf lilyturf tuber, 30 parts of dendrobium, 50 parts of Chinese yam, 30 parts of kudzuvine root, 15 parts of ginseng, 30 parts of astragalus root, 30 parts of shizandra berry, 30 parts of white paeony root, 20 parts of platycodon root, 20 parts of burdock, 20 parts of figwort root, 20 parts of glossy privet fruit, 25 parts of eclipta, 12 parts of cassia twig and 9 parts of liquorice.
Example 3
A traditional Chinese medicine composition with the effects of tonifying qi and promoting the production of body fluid comprises the following components in parts by weight: 25 parts of radix glehniae, 20 parts of dwarf lilyturf tuber, 25 parts of dendrobium, 40 parts of Chinese yam, 25 parts of kudzuvine root, 15 parts of ginseng, 40 parts of astragalus root, 20 parts of shizandra berry, 25 parts of white paeony root, 20 parts of platycodon root, 20 parts of burdock, 20 parts of figwort root, 20 parts of glossy privet fruit, 20 parts of eclipta, 12 parts of cassia twig and 8 parts of liquorice.
Comparative example 1
A traditional Chinese medicine composition with the effects of tonifying qi and promoting the production of body fluid comprises the following components in parts by weight: 25 parts of codonopsis pilosula, 20 parts of dwarf lilyturf tuber, 25 parts of dendrobium, 40 parts of Chinese yam, 25 parts of kudzuvine root, 15 parts of ginseng, 40 parts of astragalus, 20 parts of dark plum fruit, 25 parts of white paeony root, 20 parts of platycodon root, 20 parts of burdock, 20 parts of figwort root, 20 parts of glossy privet fruit, 20 parts of eclipta, 12 parts of cassia twig and 8 parts of liquorice.
Comparative example 2
A traditional Chinese medicine composition with the effects of tonifying qi and promoting the production of body fluid comprises the following components in parts by weight: 25 parts of radix glehniae, 20 parts of dwarf lilyturf tuber, 25 parts of dendrobium, 40 parts of Chinese yam, 25 parts of kudzuvine root, 15 parts of ginseng, 40 parts of astragalus root, 20 parts of shizandra berry, 25 parts of white paeony root, 20 parts of platycodon root, 20 parts of burdock, 20 parts of figwort root, 20 parts of glossy privet fruit, 20 parts of eclipta and 8 parts of liquorice.
Comparative example 3
A traditional Chinese medicine composition with the effects of tonifying qi and promoting the production of body fluid comprises the following components in parts by weight: 25 parts of radix glehniae, 20 parts of dwarf lilyturf tuber, 25 parts of dendrobium, 40 parts of Chinese yam, 25 parts of kudzuvine root, 15 parts of ginseng, 40 parts of astragalus root, 20 parts of shizandra berry, 25 parts of white paeony root, 20 parts of platycodon root, 20 parts of burdock, 20 parts of figwort root, 20 parts of glossy privet fruit, 20 parts of epimedium herb, 12 parts of cassia twig and 8 parts of liquorice.
Test examples
1. Clinical data
1.1 selected cases were all from hospitalized patients in the medical college of Chuanbei in the year 2020-2022, 210 cases were all 102 men and 108 women, the ages were all between 36-78 years, the average ages were 48.82 years, the cases were randomly divided into 7 groups of 30 persons each, and the data of sex, age, disease and radiation dose in each group were balanced and comparable.
1.2 diagnostic criteria
All patients have clear pathological basis, are clearly diagnosed as malignant tumor, and accord with the relevant standard of Chinese common malignant tumor diagnosis and treatment Specification; (2) all patients are in or out of radiotherapy treatment; (3) Reference Zhu Yifeng, etc. The symptoms of deficiency of both qi and yin are pale complexion, dizziness, listlessness, palpitation, insomnia, spontaneous perspiration, debilitation, anorexia, pale tongue with white coating, thready and weak pulse, dry mouth, dry throat, sore throat, and dry stool. (4) sign informed consent.
1.3 exclusion criteria
(1) Patients who used the drug for this trial had a clear history of allergy or refused the treatment with the drug; (2) unwilling to sign informed consent or a person falling off halfway; (3) those without definitive pathological diagnosis; (4) Patients are combined with serious heart, liver and kidney dysfunction, serious abnormal hematopoietic system and other diseases; (5) those suffering from a history of refractory mental illness; (6) patients with severe loss of clinical data.
2 method
2.1 the treatment groups are divided into 6 groups, the control group is 1 group, and the treatment group and the control group are respectively treated with western medicine symptomatic support treatment: such as fluid infusion, nutritional support, pain relief, antiemetic, blood pressure reduction, correction of anemia, anti-infection, etc., and the agents of examples 1-3 and comparative examples 1-3 are administered to patients in different treatment groups, respectively, and the treatment condition of each group of patients is observed in the control group without taking any drug.
The reagents in examples 1-3 and comparative examples 1-3 were prepared by decocting the following steps: soaking the above Chinese medicinal decoction pieces in cold water for 30min after soaking the decoction pieces for about 2cm, boiling with strong fire, maintaining with slow fire for about 20min, filtering to obtain decoction, decocting with water for 2 times again, and mixing the decoction obtained from 3 times with about 1000ml of decoction.
The medicine taking method comprises the following steps: taken three times a day, about 150ml each time, warm after meals.
2.2 efficacy assessment criteria:
the syndrome of deficiency of both qi and yin in traditional Chinese medicine is integrated: the symptoms of deficiency of both qi and yin are incorporated by reference to the "guidelines for clinical study of New Chinese drugs (trial run)" published by the national science and technology Press in 2002: the symptoms of mental fatigue, hypodynamia, no speaking, dry mouth and throat, dysphoria with feverish sensation in the chest, and constipation are classified into 5 categories, each symptom is classified into four categories, 0 indicates "none", 1 indicates "light", 2 indicates "medium", 3 indicates "heavy", and the higher the score is, the more serious.
The nimodipine method is adopted and is divided into four grades: and (3) healing: the Chinese medicine symptom score is reduced by more than 95 percent. The effect is shown: the Chinese medicine symptom score is reduced by less than 95 percent and more than or equal to 70 percent. The method is effective: the total integral is reduced by less than 70 percent and more than or equal to 30 percent. Invalidation: the Chinese medicine symptoms score is reduced by less than 30 percent, and no change or aggravation is caused. Total effective rate= (number of clinical recovery cases + number of significant cases + number of effective cases)/total number of cases of the group 100%.
3. Results
The data in the above table shows that the medicament prepared by the formulation in the embodiments 1-3 of the application treats patients after radiotherapy, and the symptoms of mental fatigue, hypodynamia, no speaking, dry mouth and throat, dysphoria with feverish sensation and constipation of the patients are relieved and even disappear; and after the formulas in the comparative examples 1-3 are adjusted, the results show that the therapeutic effect of the formulas in the comparative examples 1-3 is reduced mainly due to the change of the compatibility of medicinal materials among the formulas.
In the comparison document 1, radix glehniae is replaced by radix codonopsis pilosulae with similar effects, schisandra chinensis is replaced by dark plum with similar effects, each medicinal material has unique parts although the effects of the medicinal materials after replacement are similar, and the effect of the composition after replacement is poor mainly due to the fact that the compatibility between radix glehniae and radix ophiopogonis disappears and the tonifying effect of the schisandra chinensis disappears.
The use of cassia twig is canceled in the comparison document 2, so that the medicaments in the formula are all yin nourishing medicaments, and the effects of nourishing yin and promoting the production of body fluid can be generated, but excessive yin nourishing is caused to hurt yang due to the fact that yang qi is not considered, so that yin and yang are uncoordinated, and the effect of nourishing yin is also poor.
In comparative example 3, eclipta was replaced with epimedium herb having a similar effect, and although epimedium herb has a yang tonifying effect, the elimination of eclipta resulted in disappearance of interaction between eclipta and glossy privet fruit, and thus, the final therapeutic effect was also deteriorated.
Claims (5)
1. The traditional Chinese medicine composition with the effects of tonifying qi and promoting the production of body fluid is characterized by comprising the following components in parts by weight: 20-30 parts of radix glehniae, 15-20 parts of dwarf lilyturf tuber, 15-30 parts of dendrobium, 30-50 parts of Chinese yam, 15-30 parts of kudzuvine root, 10-15 parts of ginseng, 30-50 parts of astragalus mongholicus, 15-20 parts of schisandra chinensis, 15-30 parts of white paeony root, 15-20 parts of platycodon grandiflorum, 15-20 parts of burdock, 15-20 parts of figwort root, 15-20 parts of glossy privet fruit, 15-20 parts of eclipta, 6-12 parts of cassia twig and 6-9 parts of liquorice.
2. The traditional Chinese medicine composition with the effects of tonifying qi and promoting the production of body fluid according to claim 1, which is characterized by comprising the following components in parts by weight: 25 parts of radix glehniae, 20 parts of dwarf lilyturf tuber, 25 parts of dendrobium, 40 parts of Chinese yam, 25 parts of kudzuvine root, 15 parts of ginseng, 40 parts of astragalus root, 20 parts of shizandra berry, 25 parts of white paeony root, 20 parts of platycodon root, 20 parts of burdock, 20 parts of figwort root, 20 parts of glossy privet fruit, 20 parts of eclipta, 12 parts of cassia twig and 8 parts of liquorice.
3. The method for preparing the traditional Chinese medicine composition with the effects of tonifying qi and promoting the production of body fluid according to any one of claims 1 to 2, wherein the medicine is decocted or powdered for administration.
4. The method for preparing the traditional Chinese medicine composition with the effects of tonifying qi and promoting the production of body fluid according to claim 3, wherein the operation method of decoction is as follows: soaking the above materials in cold water for 20-50min, boiling with strong fire, decocting with slow fire for 10-20min, filtering, collecting filtrate, decocting with water twice, filtering, and mixing all filtrates.
5. The method for preparing the traditional Chinese medicine composition with the effects of tonifying qi and promoting the production of body fluid according to claim 3, wherein the method for powdering comprises the following steps: pulverizing the above materials, and sieving with 100-120 mesh sieve to obtain fine powder.
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| CN1375278A (en) * | 2001-03-21 | 2002-10-23 | 武汉莱奇尔中药现代化研究开发有限公司 | Micron level Chinese medicine liquid extract preparation and its preparation process |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1375278A (en) * | 2001-03-21 | 2002-10-23 | 武汉莱奇尔中药现代化研究开发有限公司 | Micron level Chinese medicine liquid extract preparation and its preparation process |
Non-Patent Citations (2)
| Title |
|---|
| 化疗加扶正中草药治疗恶性肿瘤的临床观察;王勇强;苏东峰;王仲玉;陈淑萍;;吉林医学;-;第-卷(第17期);3438-3439 * |
| 益气养阴法治疗鼻咽癌放疗并发症;刘种德 等;湖南中医杂志;第13卷(第2期);16、17 * |
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