CN114177243A - Traditional Chinese medicine composition for preventing and adjuvant therapy of liver tumor and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for preventing and adjuvant therapy of liver tumor and preparation method and application thereof Download PDFInfo
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- CN114177243A CN114177243A CN202111649438.9A CN202111649438A CN114177243A CN 114177243 A CN114177243 A CN 114177243A CN 202111649438 A CN202111649438 A CN 202111649438A CN 114177243 A CN114177243 A CN 114177243A
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Abstract
The invention provides a traditional Chinese medicine composition for preventing and treating liver tumor in an auxiliary way, a preparation method and application thereof, belonging to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises astragalus membranaceus, angelica sinensis, radix bupleuri, cornus officinalis, salvia miltiorrhiza, bighead atractylodes rhizome, rhizoma anemarrhenae, pericarpium citri reticulatae, radix rehmanniae preparata, medlar and cassia twig, and the astragalus membranaceus is used as a monarch drug, so that the curative effects of strengthening body resistance and eliminating evil, storing vital qi and keeping the evil dry can be achieved, the traditional Chinese medicine composition has good prevention and adjuvant therapy effects on liver tumors, the recurrence of postoperative liver tumors is effectively prevented, the survival time of patients is prolonged, and the life quality of the patients is improved. The traditional Chinese medicine composition has broad-spectrum applicability, easily obtained raw materials, safety, no toxic or side effect, simple preparation method and low preparation cost.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing and assisting in treating liver tumors, and a preparation method and application thereof.
Background
The primary liver tumor is one of the common clinical tumors, wherein primary hepatocellular carcinoma (HCC) accounts for more than 90% of primary liver cancer (hereinafter referred to as liver cancer). The newly discovered liver cancer patients and the patients who die of the liver cancer in China are about 11 thousands of people respectively, account for 45 percent of the liver cancer patients all over the world, and are one of three major life cancers. And the liver cancer patients have no early signs or symptoms, develop rapidly, have high malignancy degree and generally can survive for three to six months on average after diagnosis. Therefore, the prevention and treatment of liver cancer is one of the tasks in China's medical and health profession.
Early detection and early treatment are important means for prolonging the life of patients. Early detection of clinical treatment mainly includes surgery and radiotherapy and chemotherapy. For patients found at an advanced stage, non-surgical treatment is generally adopted. For example: ultrasound ablation therapy, and the like. The disadvantages of these treatments are: the radiotherapy and chemotherapy has great damage to other organs of human body and short life prolonging time in non-operative treatment. Therefore, the clinical treatment of liver tumor is far from satisfactory, and the refractory property of liver tumor has become a common concern in medical field.
The traditional Chinese medicine is a treasure of Chinese nation. In long-term clinical practice of traditional Chinese medicine, abundant experience is accumulated for diagnosis and treatment of liver cancer, a large amount of traditional Chinese medicine prescription data is reserved, and the traditional Chinese medicine prescription data is often used as an effective auxiliary method for treating liver tumors at present. However, in the clinical practice, the difference between the treatment based on syndrome differentiation and the theoretical basis and the definition of the traditional Chinese medicine results in the large difference between the components and the content of the traditional Chinese medicine formula, the curative effect varies from person to person, and certain toxic and side effects can also occur due to improper medication. Therefore, a traditional Chinese medicine formula for preventing and treating tumors in an auxiliary manner, which has broad spectrum, obvious curative effect and no toxic or side effect, is lacked at present.
Disclosure of Invention
In view of the above, the present invention aims to provide a traditional Chinese medicine composition for prevention and adjuvant therapy of liver tumor, which has the characteristics of broad-spectrum applicability, safety, no toxic or side effect, and can effectively inhibit the occurrence and development of liver tumor, and the recurrence of postoperative liver tumor, and prolong the survival time of patients.
In order to achieve the above purpose, the invention provides the following technical scheme:
a traditional Chinese medicine composition for preventing and adjuvant therapy of liver tumor comprises the following raw materials in parts by weight: 15-25 parts of astragalus membranaceus, 5-15 parts of angelica sinensis, 2-10 parts of radix bupleuri, 10-20 parts of cornus officinalis, 5-15 parts of salvia miltiorrhiza, 7-15 parts of bighead atractylodes rhizome, 10-20 parts of rhizoma anemarrhenae, 5-15 parts of pericarpium citri reticulatae, 10-20 parts of radix rehmanniae preparata, 7-15 parts of wolfberry and 7-15 parts of cassia twig.
Preferably, the feed comprises the following raw materials in parts by weight: 17-20 parts of astragalus membranaceus, 7-10 parts of angelica sinensis, 3-8 parts of radix bupleuri, 13-17 parts of cornus officinalis, 7-10 parts of salvia miltiorrhiza, 8-12 parts of bighead atractylodes rhizome, 11-15 parts of rhizoma anemarrhenae, 7-10 parts of pericarpium citri reticulatae, 13-17 parts of radix rehmanniae preparata, 8-12 parts of wolfberry and 8-12 parts of cassia twig.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: mixing the astragalus, the angelica, the radix bupleuri, the cornus officinalis, the salvia miltiorrhiza, the bighead atractylodes rhizome, the rhizoma anemarrhenae, the dried orange peel, the prepared rhizome of rehmannia, the medlar and the cassia twig to obtain a traditional Chinese medicine mixture, mixing the traditional Chinese medicine mixture with water, soaking, decocting for 1-3 times, filtering, and combining filtrates to obtain the traditional Chinese medicine composition.
Preferably, the mass ratio of the traditional Chinese medicine mixture to the water is 1 (7-13).
Preferably, the soaking time is 10-30 min.
Preferably, the time of each decoction is 40-120 min.
Preferably, the number of times of decoction is 2; the decocting step comprises decocting the above materials for the first time, filtering, adding water to the residue, decocting for the second time, and filtering to obtain a second decoction.
Preferably, the mass ratio of the dregs of a decoction to the water is 1 (5-8).
The invention also provides application of the traditional Chinese medicine composition or the traditional Chinese medicine composition obtained by the preparation method in preparation of a medicine for preventing and/or treating liver tumor.
The invention also provides a medicament for preventing and/or treating liver tumor, which is prepared into tablets, capsules, granules, pills or oral liquid by adding pharmaceutically acceptable auxiliary materials into the traditional Chinese medicine composition.
Compared with the prior art, the invention has the following beneficial effects:
the traditional Chinese medicine composition disclosed by the invention integrates 11 raw materials, takes astragalus as a monarch drug, radix bupleuri and cornus officinalis as ministers, takes pericarpium citri reticulatae, rhizoma atractylodis macrocephalae and rhizoma anemarrhenae as assistants, and takes cassia twig, radix rehmanniae preparata, medlar and radix salviae miltiorrhizae as guides, so that the curative effects of strengthening body resistance and eliminating evil, storing body resistance and keeping evil qi undried can be achieved, the traditional Chinese medicine composition has good prevention and auxiliary treatment effects on liver tumors, the recurrence of postoperative liver tumors can be effectively prevented, the survival time of patients can be effectively prolonged, and the life quality of the patients can be improved. The traditional Chinese medicine composition has broad-spectrum applicability, easily obtained raw materials, safety, no toxic or side effect, simple preparation method and low preparation cost.
Drawings
FIG. 1 is a schematic anatomical diagram of liver tissues of mice in a treatment group and a control group in Experimental example 1, wherein the upper part is the schematic anatomical diagram of liver tissues of mice in the treatment group, and the lower part is the schematic anatomical diagram of liver tissues of mice in the control group;
FIG. 2 shows the sizes and numbers of tumors in mice of the treated group and the control group in Experimental example 1.
Detailed Description
The invention provides a traditional Chinese medicine composition for preventing and treating liver tumor in an auxiliary way, which comprises the following raw materials in parts by weight: 15-25 parts of astragalus membranaceus, 5-15 parts of angelica sinensis, 2-10 parts of radix bupleuri, 10-20 parts of cornus officinalis, 5-15 parts of salvia miltiorrhiza, 7-15 parts of bighead atractylodes rhizome, 10-20 parts of rhizoma anemarrhenae, 5-15 parts of pericarpium citri reticulatae, 10-20 parts of radix rehmanniae preparata, 7-15 parts of wolfberry and 7-15 parts of cassia twig.
The astragalus root of the present invention is preferably 17 to 20 parts by weight, more preferably 18 parts by weight, and is astragalus root, i.e., astragalus mongholicus, which is a plant of the genus astragalus of the family leguminosae, which is perennial. Astragalus root can be used as a medicine, has sweet taste and mild nature, and enters lung, spleen, liver and kidney meridians. Has effects of invigorating qi, consolidating superficial resistance, promoting urination, tonifying heart, lowering blood pressure, resisting bacteria, removing toxic substance, promoting pus discharge, promoting granulation, enhancing capillary resistance, arresting sweating, and treating exterior deficiency, spontaneous perspiration, internal injury due to qi deficiency, spleen deficiency, diarrhea, edema, carbuncle, cellulitis, etc.
The weight portion of the angelica sinensis is preferably 7-10 portions, more preferably 9 portions, and the angelica sinensis is dried root of angelica sinensis of an Umbelliferae plant. Sweet, pungent and warm in nature and flavor, enter liver, heart and spleen meridians. Enriching the blood; promoting blood circulation; regulating menstruation and relieving pain; moistening dryness and smoothing intestine. The main symptoms are blood deficiency; menoxenia; amenorrhea; dysmenorrhea; the accumulation of symptoms; (ii) metrorrhagia and metrostaxis; abdominal pain due to deficiency-cold; flaccidity and paralysis; numbness of the skin; intestinal dryness and difficult defecation; severe dysentery with diarrhea; carbuncle, cellulitis, sore and ulcer; injury from falling.
The weight portion of the bupleurum is preferably 3 to 8 portions, more preferably 5 portions, and the bupleurum is the dried root of bupleurum or bupleurum stenophyllum of the Umbelliferae. Bitter in property and slightly cold in nature, entering liver and gallbladder meridians. Has the functions of harmonizing exterior and interior, soothing liver and invigorating yang. Can be used for treating common cold, fever, malaria, stagnation of qi due to depression of the liver, distending pain of chest and hypochondrium, rectocele, uterine prolapse, and menoxenia.
The weight portion of the dogwood pulp is preferably 13-17 parts, more preferably 15 parts, and the dogwood pulp is dried mature pulp of dogwood belonging to the dogwood family. Sour and astringent taste, slightly warm in nature. It enters liver and kidney meridians. Has the efficacies of tonifying liver and kidney, astringing and relieving depletion. It is commonly used for vertigo, tinnitus, soreness and pain of waist and knees, impotence, spermatorrhea, enuresis, frequent micturition, metrorrhagia, leukorrhagia, profuse sweating, exhaustion, internal heat, and diabetes.
The weight portion of the salvia miltiorrhiza is preferably 7-10 portions, more preferably 9 portions, and the salvia miltiorrhiza is dried roots and rhizomes of salvia miltiorrhiza belonging to the family labiatae. Bitter and slightly cold in taste. It enters heart and liver meridians. Has the effects of activating blood circulation to dissipate blood stasis, stimulating the menstrual flow to relieve pain, clearing away the heart-fire and relieving restlessness, cooling blood and eliminating carbuncle. Can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.
The weight portion of the bighead atractylodes rhizome is preferably 8-12 parts, more preferably 10 parts, and the bighead atractylodes rhizome is a perennial herb of the family Compositae of the order Campanulales. White atractylodes rhizome (rhizome): bitter, sweet and warm. It enters spleen and stomach meridians. Invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion. Can be used for treating spleen deficiency, anorexia, dyspepsia, diarrhea, edema, spontaneous perspiration, and threatened abortion.
The weight portion of the rhizoma anemarrhenae is preferably 11-15 portions, more preferably 12 portions, and the rhizoma anemarrhenae is a perennial herbaceous plant. Bitter in property and cold in nature. It enters lung, stomach and kidney meridians. Has the effects of clearing heat, purging fire, nourishing yin and moistening dryness. Can be used for treating fever polydipsia, lung heat dry cough, hectic fever due to yin-deficiency, internal heat diabetes, and constipation due to intestinal dryness.
The dried orange peel is preferably 7-10 parts by weight, more preferably 9 parts by weight, and is mature pericarp of Rutaceae plant tangerine and its cultivar. Warm in nature, pungent and bitter in flavor. It enters spleen, stomach and lung meridians. The main functions are regulating qi, stimulating appetite, eliminating dampness and phlegm, and treating spleen and stomach diseases. Belongs to qi regulating medicine, and also has the effects of resisting gastric ulcer, protecting liver, promoting bile flow, boosting pressure, tonifying heart, expanding coronary artery and resisting tumor.
The prepared rhizome of rehmannia of the invention is preferably 13 to 17 parts by weight, more preferably 15 parts by weight, and the prepared rhizome of rehmannia is rehmannia which is a plant of Scrophulariaceae. Sweet in nature and taste, slightly warm. It enters liver and kidney meridians. The main functions are nourishing yin and enriching blood. It is indicated for deficiency of yin and blood, atrophy and weakness of waist and knees, fatigue, cough, steaming bone, seminal emission, metrorrhagia, menoxenia, diabetes, scanty urine, deafness and blurred vision.
The medlar of the invention is preferably 8 to 12 parts by weight, more preferably 10 parts by weight, and the medlar is the fruit of medlar which belongs to the family of solanaceae and the genus of medlar. Sweet in nature and taste and mild in nature. It enters liver and kidney meridians. The main functions are nourishing kidney, moistening lung, tonifying liver and improving vision. It is indicated for liver and kidney yin deficiency, soreness and weakness of waist and knees, dizziness, blurred vision, hyperdacryosis, cough due to asthenia, diabetes, and spermatorrhea.
The cassia twig of the invention is preferably 8 to 12 parts by weight, more preferably 10 parts by weight, and belongs to cinnamoles, lauraceae and medium arbors; pungent, sweet and warm in nature. It enters heart, lung and bladder meridians. Has effects of inducing sweat, expelling pathogenic factors from muscles, warming and dredging channels, supporting yang, regulating qi, and lowering qi. It is commonly used for wind-cold type common cold, abdominal cold pain, amenorrhea due to blood cold, arthralgia, phlegm and fluid retention, edema and palpitation.
The theoretical formulation of the invention is based on the traditional Chinese medicine theory of 'yang moving, dispersing, solidifying and gasifying, yin static, solidifying and forming' of Zhangjing Yue of Ming dynasty physicians. The five elements of the liver belong to wood, which is pleased in the nature of the temperature in spring festival, and mainly stores blood by transportation and excretion, uses yin to yang, and uses blood to qi by right and left. Liver tumor and liver cirrhosis are all liver dysfunction. Yang qi transformation, yin formation and liver cirrhosis, wherein the tumor is the deficient transformation of yang, the tumor is the form with qi at the root, and the transformation of qi is the dispersion of qi and the stagnation of qi is the coagulation. Therefore, the formula takes the astragalus root as a monarch, the radix bupleuri and the cornus officinalis as ministers, the dried orange peel, the bighead atractylodes rhizome and the rhizoma anemarrhenae as assistants, and the cassia twig, the prepared rhizome of rehmannia, the medlar and the salvia miltiorrhiza as guides, so as to tonify liver qi, increase the temperature of the astragalus root and supplement liver qi. Huang Qi is used to treat all the diseases caused by liver deficiency. Liver cirrhosis, a tumor refers to the formation of yin and insufficiency of yang. The liver is sour, the pulp of dogwood fruit is sour and astringent, the property is slightly warm, the liver and kidney are tonified, the medicine is introduced into the liver, and the astragalus root is used together to nourish yin and tonify yang, and yang is moved to yin powder. The use of Bupleurum root in the recipe, the use of Bupleurum root in less dosage, is intended to raise yang, the use of Bupleurum root in more dosage will lead to liver failure, and the use of Bupleurum root in more dosage will lead to liver qi deficiency. Corni fructus can astringe liver yin, and bupleuri radix can promote liver yang. Huang Qi is a medicine for tonifying lung and spleen, and rising temperature of Huang Qi can tonify qi, so it is also a yang-qi rising in rain. Anemarrhena rhizome, rhizoma anemarrhenae, being cold, moistening and nourishing yin, combines the four herbs and the two herbs in the rain, so it is very good at ascending yang and yin, and is good at running rain. The ointment has excellent effect and can relieve dysphoria with smothery sensation, the treatment of the maladjustment can damage the kidney due to consumptive disease, the astragalus can tonify lung qi and tonify the upper source of kidney water, so that qi can generate water by itself, and the rhizoma anemarrhenae can nourish body fluid in the lung, so that yin and yang are not surpassed, and the function of generating water is general as well as recorded in Western of medicine, astragalus solution. The combination of astragalus root and rhizoma anemarrhenae, the generation of golden water, and the nourishing of water and culvert wood. The astragalus is used as a medicine for tonifying spleen and lung, is combined with the bighead atractylodes rhizome and the dried orange peel, eliminates dampness and promotes diuresis, invigorates qi and strengthens spleen, the dried orange peel is bitter in taste, pungent, warm in nature, regulates qi and strengthens spleen, eliminates dampness and reduces phlegm, and has the effects of ascending and descending, spleen yang generation and phlegm and fluid self-transformation. The cassia twig and the astragalus are used together to supplement the yang of heart and lung and the sufficient yang of heart and lung, such as the beautiful middle-jiao, the yin-haze opens automatically, the salvia is bitter and cold, the salvia enters heart and liver channels, the blood circulation is promoted, the blood stasis is removed, the pain is relieved, the blood is cooled and the swelling is reduced. The prepared rehmannia root and the medlar have the effects of nourishing kidney yin and warming kidney yang, and the whole formula is combined, so that the overall view of the traditional Chinese medicine is reflected, wherein yin ascends to the descending of yang, liver ascends along with the left of spleen qi, and gallbladder descends along with the right of stomach qi. Lung-metal produces kidney water, kidney water nourishes liver wood, liver wood produces heart fire, heart fire descends to strengthen spleen earth, earth is built to produce metal. Realizes the treatment of qi circulation, yin balancing and yang secret, spirit control, and internal storage of healthy qi, and no pathogenic factor. The whole formula is mild in medicine, regulates qi activity, regulates the whole environment, cures incurable diseases, preserves health, prevents and treats diseases, is safe and effective and has no toxic or side effect.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: mixing the astragalus, the angelica, the radix bupleuri, the cornus officinalis, the salvia miltiorrhiza, the bighead atractylodes rhizome, the rhizoma anemarrhenae, the dried orange peel, the prepared rhizome of rehmannia, the medlar and the cassia twig to obtain a traditional Chinese medicine mixture, mixing the traditional Chinese medicine mixture with water, soaking, decocting for 1-3 times, filtering, and combining filtrates to obtain the traditional Chinese medicine composition.
In the invention, the mass ratio of the traditional Chinese medicine mixture to water is preferably 1 (7-13), more preferably 1:10, the soaking time is preferably 10-30min, more preferably 20min, the time of each decoction is preferably 40-120min, more preferably 60min, and the number of times of decoction is preferably 2; the decocting step comprises the steps of decocting for the first time, filtering, adding water into the decoction dregs for decocting for the second time, and filtering to obtain a second decoction filtrate, wherein the mass ratio of the decoction dregs to the water is preferably 1 (5-8), and more preferably 1: 6.
The traditional Chinese medicine composition prepared by the invention is taken 1 time each day in the morning and evening, 200 ml each time, and uncooked, cold, sticky, slippery, five-pungent and smelly foods are avoided during the taking period.
The invention also provides application of the traditional Chinese medicine composition or the traditional Chinese medicine composition obtained by the preparation method in preparation of a medicine for preventing and/or treating liver tumor.
The invention also provides a medicament for preventing and/or treating liver tumor, which is prepared into tablets, capsules, granules, pills or oral liquid by adding pharmaceutically acceptable auxiliary materials into the traditional Chinese medicine composition.
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
Example 1
Accurately weighing 18g of astragalus membranaceus, 9g of angelica sinensis, 5g of radix bupleuri, 15g of cornus officinalis, 9g of salvia miltiorrhiza, 10g of bighead atractylodes rhizome, 12g of rhizoma anemarrhenae, 10g of pericarpium citri reticulatae, 15g of radix rehmanniae preparata, 10g of medlar and 10g of cassia twig, mixing the materials, mixing the mixture with water according to the weight ratio of 1:10, soaking the mixture in the water for 20min, decocting the mixture in the water for 2h, and filtering the mixture to obtain filtrate, thus obtaining the traditional Chinese medicine composition.
Example 2
Accurately weighing 15g of astragalus, 5g of angelica, 2g of radix bupleuri, 10g of cornus officinalis, 5g of salvia miltiorrhiza, 7g of bighead atractylodes rhizome, 10g of rhizoma anemarrhenae, 5g of dried orange peel, 10g of prepared rehmannia root, 7g of medlar and 7g of cassia twig, mixing the materials and water according to a weight ratio of 1: 7, soaking in water for 30min, decocting for 40min, filtering to obtain a first filtrate and a filter residue, mixing the filter residue with water according to the weight ratio of 1:6, decocting for 40min, filtering to obtain a second filtrate, and mixing with the first filtrate to obtain the traditional Chinese medicine composition.
Example 3
Accurately weighing 25g of astragalus membranaceus, 15g of angelica sinensis, 10g of radix bupleuri, 20g of cornus officinalis, 15g of salvia miltiorrhiza, 15g of bighead atractylodes rhizome, 20g of rhizoma anemarrhenae, 15g of pericarpium citri reticulatae, 20g of radix rehmanniae preparata, 15g of medlar and 15g of cassia twig, mixing the mixture with water according to the weight ratio of 1:13, soaking the mixture in water for 10min, decocting the mixture for 120min, filtering the mixture to obtain first filtrate and filter residue, mixing the filter residue with the water according to the weight ratio of 1:5, decocting the mixture for 40min, filtering the mixture to obtain second filtrate, and mixing the second filtrate with the first filtrate to obtain the traditional Chinese medicine composition.
Example 4
Accurately mixing 20g of astragalus membranaceus, 12g of angelica sinensis, 5g of radix bupleuri, 15g of cornus officinalis, 12g of salvia miltiorrhiza, 15g of bighead atractylodes rhizome, 15g of rhizoma anemarrhenae, 12g of pericarpium citri reticulatae, 20g of radix rehmanniae preparata, 12g of medlar and 12g of cassia twig, mixing the mixture with water according to the weight ratio of 1:10, soaking the mixture in water for 20min, decocting the mixture for 60min, filtering the mixture to obtain first filtrate and filter residue, mixing the filter residue with the water according to the weight ratio of 1:8, decocting the mixture for 40min, filtering the mixture to obtain second filtrate, and mixing the second filtrate with the first filtrate to obtain the traditional Chinese medicine composition.
Experimental example 1
The traditional Chinese medicine composition has the effect on liver cancer of mice
The experiment is mainly completed by the experimental animal center of university of Dalian medical science.
Experimental animals: the H-ras12V transgenic liver cancer model mouse is selected as an experimental object. The liver cancer model mouse directly induces the generation and development of spontaneous liver cancer by the Ras oncogene specifically expressed in the hepatocyte, the pathological generation and development process of the liver cancer model mouse is similar to that of human liver cancer, and the liver cancer model mouse has the advantages of single genetic background, high morbidity (up to 90%), timely morbidity (6-8 months old tumor), good repeatability, regular presentation of the whole process of the generation and development of the liver cancer and the like, and provides an excellent disease animal model for verifying the curative effect of the medicament on the generation and development of the liver cancer.
The experimental method comprises the following steps: (1) 28 male H-Ras12V transgenic liver cancer model mice are selected. Groups were randomized into 2, control and treatment groups of 14 individuals each. The treatment group started to drink the traditional Chinese medicine composition of the invention in example 1 freely at 3 months of age, and replaced fresh traditional Chinese medicines every day. The control group started drinking water normally at 3 months of age. The other feeding conditions of the control group and the treatment group were not changed. During the test period, the animals were observed daily for diet, drinking water, behavioral activity, and the animal body weights were measured and recorded every 5 days. (2) By the age of 6 months, the mice were sacrificed, the livers were dissected out, weighed, photographed, and the size and number of tumors were measured.
The diet, behavior and mental state of the treated mice were normal during the experiment, and no significant change was observed. The control group mice had normal diet, behavior and mental status in the early period of the experiment (3-5 months old), and had no significant change, but in the later period of the experiment (5-6 months old), the liver tumor grew to cause symptoms of enlargement of upper abdomen, emaciation, disorder of hair, listlessness, etc. in different degrees.
As can be seen from fig. 1 and fig. 2, the occurrence and development of the tumor in the treatment group of the present invention are significantly inhibited through the comparative experiment with the control group, which proves that the traditional Chinese medicine composition of the present invention has a significant inhibiting effect on the occurrence and development of the in situ spontaneous liver tumor.
Experimental example 2
The traditional Chinese medicine composition prepared by the embodiment is applied to clinical treatment
Zhangqi, male, 68 years old, Dalian city, Liaoning province, Zhenju: liver cancer. Relapse after two times of interventional therapy is caused, the three traditional Chinese medicines have poor effect on treating the residual moon, and after the targeted medicine is taken, the liver area is painful and full, the body is painful, the appetite is poor, the loose stool is discharged, the tongue is red, the tongue coating is yellow and greasy, and the history of hypertension and blood sugar exists. By taking the traditional Chinese medicine composition disclosed by the embodiment 1 of the invention, the traditional Chinese medicine composition is taken 1 time in the morning and evening, 200 ml of the composition is taken every time, and uncooked, cold, sticky and slippery food and five pungent and smelly food are avoided during the taking period. After the decoction is taken for half a month, the liver area is full and relieved, the body pain is relieved, the appetite is increased, the targeted medicine is stopped taking, the decoction is continuously taken, the aftereffect of two months disappears, the mental state is good, the medicine is stopped taking, and the normal state of the life is recovered at present.
Huang-Zhi, female 82 years old, Dalian City in Liaoning province, Hospital diagnosis: in the late stage of liver cancer, the householder is informed of the danger of diseases. By taking the traditional Chinese medicine composition of the embodiment 3 of the invention, the traditional Chinese medicine composition is taken 1 time in the morning and evening, 200 ml each time, and uncooked, cold, sticky and slippery food and five pungent and smelly food are avoided during the taking period. After the administration of the formula for half a month, the pain of the liver area is caused, the appetite is increased, after the administration of the formula for more than a month, the rest symptoms are greatly relieved, and the mental state is good.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for preventing and adjuvant therapy of liver tumor is characterized by comprising the following raw materials in parts by weight: 15-25 parts of astragalus membranaceus, 5-15 parts of angelica sinensis, 2-10 parts of radix bupleuri, 10-20 parts of cornus officinalis, 5-15 parts of salvia miltiorrhiza, 7-15 parts of bighead atractylodes rhizome, 10-20 parts of rhizoma anemarrhenae, 5-15 parts of pericarpium citri reticulatae, 10-20 parts of radix rehmanniae preparata, 7-15 parts of wolfberry and 7-15 parts of cassia twig.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 17-20 parts of astragalus membranaceus, 7-10 parts of angelica sinensis, 3-8 parts of radix bupleuri, 13-17 parts of cornus officinalis, 7-10 parts of salvia miltiorrhiza, 8-12 parts of bighead atractylodes rhizome, 11-15 parts of rhizoma anemarrhenae, 7-10 parts of pericarpium citri reticulatae, 13-17 parts of radix rehmanniae preparata, 8-12 parts of wolfberry and 8-12 parts of cassia twig.
3. A method for preparing the traditional Chinese medicine composition of claim 1 or 2, which is characterized by comprising the following steps: mixing the astragalus, the angelica, the radix bupleuri, the cornus officinalis, the salvia miltiorrhiza, the bighead atractylodes rhizome, the rhizoma anemarrhenae, the dried orange peel, the prepared rhizome of rehmannia, the medlar and the cassia twig to obtain a traditional Chinese medicine mixture, mixing the traditional Chinese medicine mixture with water, soaking, decocting for 1-3 times, filtering, and combining filtrates to obtain the traditional Chinese medicine composition.
4. The preparation method of claim 3, wherein the mass ratio of the traditional Chinese medicine mixture to the water is 1 (7-13).
5. The method of claim 3, wherein the soaking time is 10-30 min.
6. The method of claim 3, wherein the time for each decoction is 40-120 min.
7. The method according to claim 3 or 6, wherein the number of times of decoction is 2; the decocting step comprises decocting the above materials for the first time, filtering, adding water to the residue, decocting for the second time, and filtering to obtain a second decoction.
8. The preparation method according to claim 7, wherein the mass ratio of the decoction dregs to the water is 1 (5-8).
9. Use of the Chinese medicinal composition of claim 1 or 2 or the Chinese medicinal composition obtained by the preparation method of any one of claims 3 to 8 in the preparation of a medicament for preventing and/or treating liver tumor.
10. A medicament for preventing and/or treating liver tumor, which is characterized in that pharmaceutically acceptable auxiliary materials are added into the traditional Chinese medicine composition of claim 1 or 2 to prepare tablets, capsules, granules, pills or oral liquid.
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| CN202111649438.9A Pending CN114177243A (en) | 2021-12-30 | 2021-12-30 | Traditional Chinese medicine composition for preventing and adjuvant therapy of liver tumor and preparation method and application thereof |
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Citations (4)
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|---|---|---|---|---|
| CN1451413A (en) * | 2002-04-12 | 2003-10-29 | 周遇春 | Flavoured siberian solomonseal rhizome decoction and preparing process thereof |
| CN101837108A (en) * | 2010-05-12 | 2010-09-22 | 李广斌 | Liver and kidney yin-nourishing soup |
| CN102657815A (en) * | 2012-05-04 | 2012-09-12 | 毛世平 | Chinese patent medicine orally-taken pill for treating malignant tumors |
| CN109893574A (en) * | 2017-12-11 | 2019-06-18 | 青岛市中心医院 | A kind of Chinese medicine composition, the method that decoction is prepared by it and the traditional Chinese herbal decoction prepared by this method |
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2021
- 2021-12-30 CN CN202111649438.9A patent/CN114177243A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1451413A (en) * | 2002-04-12 | 2003-10-29 | 周遇春 | Flavoured siberian solomonseal rhizome decoction and preparing process thereof |
| CN101837108A (en) * | 2010-05-12 | 2010-09-22 | 李广斌 | Liver and kidney yin-nourishing soup |
| CN102657815A (en) * | 2012-05-04 | 2012-09-12 | 毛世平 | Chinese patent medicine orally-taken pill for treating malignant tumors |
| CN109893574A (en) * | 2017-12-11 | 2019-06-18 | 青岛市中心医院 | A kind of Chinese medicine composition, the method that decoction is prepared by it and the traditional Chinese herbal decoction prepared by this method |
Non-Patent Citations (1)
| Title |
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| 蒋锐沅等: "基于"阳化气,阴成形"理论探讨原发性肝癌的病因与治法", 《四川中医》 * |
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