CN104758854A - Chinese herba preparation for treating premature ovarian failure - Google Patents
Chinese herba preparation for treating premature ovarian failure Download PDFInfo
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Abstract
The invention discloses a Chinese herba preparation for treating the premature ovarian failure. The Chinese herba preparation is made of prepared rehmannia root, fried Chinese yam, teasel root, vinegar-processed radix bupleuri, rhizoma cyperi, curcuma aromatica, loranthus parasiticus, eucommia ulmoides, semen cuscutae, flatstem milkvetch seed, barbary wolfberry fruit, achyranthes root, dogwood, angelica sinensis, ligusticum wallichii, radix paeoniae alba, fried bighead atractylodes rhizome, codonopsis pilosula, semen plantaginis, glossy privet fruit, cornu cervi degelatinatum, colla corii asini, trigone and curcuma zedoary according to a certain weight ratio. The Chinese herba preparation has the effects of nourishing yin and blood, boosting essence, filling marrow, supplementing qi, promoting the production of body fluid, promoting qi circulation and relieving depression; the Chinese herba preparation has the good effect on improving the ovarian function, the physique of a patient can be strengthened, the Chinese herba preparation further has the advantages of being low in price and free of toxic and side effects, and therefore the effect of treating the premature ovarian failure is achieved.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for the treatment of premature ovarian failure, the invention still further relates to the preparation method of this Chinese medicine preparation.
Background technology
Premature ovarian failure refers to that women once had natural menstrual cycle, and before 35 years old, occur that ovarian atrophy continues amenorrhea.Meanwhile, clinical signs secondary sex characteristics is shunk back, and occurs that face is warmed, the menopause syndrome such as vexed, irritability; Easy catching a cold at ordinary times, blood follicule-stimulating hormone (FSH) level raises, and reaches more than 40 units, is equivalent to postmenopausal women's level; And blood estradiol level is significantly low.The obvious atrophy of gynecologial examination internal genitalia, vaginal mucosa is thin and congested.Cut open the belly and do biopsy of ovary, visible ovarian atrophy, under microscope, see in ovarian cortex being fibrous tissue, visible without folliculus at different levels such as primordium folliculus.
The cause of disease of premature ovarian failure is a lot, and as infection, immune factor etc., main manifestations is 1, gonad development infertility easily occurs chain reaction in patients with premature ovarian, and after the several years, menstruation is rare until amenorrhea gradually.2, chain reaction in patients with premature ovarian easily causes the non-growth person of gonad, primary amenorrhea, germinal aplasia person menophania delay or irregular menses, dysmenorrhea.3, chain reaction in patients with premature ovarian easily causes mastatrophy sagging, and cutis laxa is coarse, nervous, and dreaminess is suspicious, cardiopalmus, osteoporosis, arthralgia, genitals's inflammation, uterine prolapse, urinary incontinence, constipation, small pox, mottle.4, chain reaction in patients with premature ovarian easily causes not ovulating, and has ovulation person, and typical POF has hectic fever, and hypogonadism shows, as night sweat, constipation, alopecia, vagina drying, sexual life pain, libido decline, hypothyroidism, urinary system infection, body weight increases, and anxiety is suspicious etc.
But premature ovarian failure treatment is got up more difficult, doctor trained in Western medicine adopts hormone therapy alternative medicine clinically, need to use estrogen and progestogen under the guidance of doctor, time research shows this estrogen and progestogen therapy, have certain effect, symptom can be improved, but it is unsatisfactory to the recovery of ovarian function, after drug withdrawal simultaneously, symptom reappears, it has been state since the ovary of patient is in, the worse situation of the ovarian function of patient can be caused in addition, the method of hormone therapy can only play the effect that index is not effected a permanent cure, up to the present, also do not have definite effective method can recover the function of ovary, therefore cure difficulty to continue to increase.
In recent years, along with Chinese medicine development, be more and more concerned with the chemotherapy that natural plant kind medicine substitutes in doctor trained in Western medicine.Chinese medicine has the integrally-regulated effect of multisystem too many levels, can improve ovarian function, improves ovarian reserve ability, and promote follicular development and ovulation, regulating menstruation and assisting pregnancy is antiabortive, is confirmed in long-term clinical practice.Effectively can treat premature ovarian failure, reasonable price is applicable to the needs of extensive patients.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of premature ovarian failure, this Chinese medicine preparation has good effect for improving ovarian function, and can strengthen patient's body constitution, and have cheap, have no side effect feature.
Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of this treatment premature ovarian failure.
Inventor is in clinical treatment practice for many years, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of premature ovarian failure repeatedly, the present invention selects Radix Rehmanniae Preparata, Rhizoma dioscoreae (parched), Radix Dipsaci, Radix Bupleuri (processed with vinegar), Rhizoma Cyperi, Radix Curcumae, Herba Taxilli, the Cortex Eucommiae, Semen Cuscutae, Semen Astragali Complanati, Fructus Lycii, Radix Achyranthis Bidentatae, Fructus Corni, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae (parched), Radix Codonopsis, Semen Plantaginis, Fructus Ligustri Lucidi, Cornu Cervi Degelatinatum, Colla Corii Asini, Rhizoma Sparganii, Rhizoma Curcumae combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is nourishing YIN and supplementing blood, benefit essence fills out marrow, supplementing QI for promoting the production of body fluid, effect of promoting QI circulation for relieving depression, thus effectively can treat premature ovarian failure.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Rehmanniae Preparata: be scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa(Gdertn) Iibosch.ex Fisch. et Mey.) tuber form through Processing methods.Nature and flavor: sweet, tepor.Return liver, kidney channel.Effect: nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.Radix Rehmanniae Preparata can be enriched blood YIN nourishing and liver-nourishing kidney-boosting, and all blood deficiency the moon loses, dizzy caused by deficiency of the liver and kindey, all can apply.
Rhizoma dioscoreae (parched): be the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb..Nature and flavor are put down, sweet.Return spleen, lung, kidney channel.Effect: spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Radix Dipsaci: be the dry root of Dipsacaceae plant Radix Dipsaci Dipsacus asperoides C. Y. Cheng et T. M. Ai (or Dipsacus asper Wall).Nature and flavor: bitter, pungent, tepor.Return liver, kidney channel.Effect: invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Only metrorrhagia, the sweet temperature of this product is supporing yang, pungent temperature cold expelling, and with controlling insufficiency of kidney-YANG, below element deficiency and cold, sexual impotence erectile problem, seminal emission lingering diarrhea, the diseases such as enuresis frequent micturition, have liver and kidney tonifying concurrently, strong bone strengthening, the merit of promoting blood circulation.
Radix Bupleuri (processed with vinegar): be Umbelliferae herbaceos perennial Radix Bupleuri Bupleurum chinense DC.(Radix Bupleuri) or Radix Bupeuri Scorzonerfolii. Bupleurum scorzonerifolium Willd.(Radix Bupleuri Scorzonerifolii) root or herb.Radix Bupleuri (processed with vinegar): get radix bupleuri tablet, mixes thoroughly with vinegar, puts in pot to fry with slow fire to exhaust and micro-dry to vinegar, takes out, dries.Nature and flavor: bitter, pungent, be slightly cold.Return liver, gallbladder meridian.Effect: reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang.Radix Bupleuri has the effect of good dispersing the stagnated live-QI to relieve the stagnation of QI, is the key medicine for the treatment of irritability stasis, to the pain over the hypochondriac region no matter in by stagnation of liver-QI, outer by hindering servant person, all can apply.
Rhizoma Cyperi: be the dry rhizome of sedge dried tuber Cyperus rotundus L..Nature and flavor: pungent, micro-hardship, micro-sweet are flat.Return liver, spleen, tri-jiao channel.Effect: promoting QI circulation for relieving depression, menstruction regulating and pain relieving, antiabortive, regulate the flow of vital energy Shu Yu, harmonizing the liver and stomach.The pungent loose hardship of this product is let out, and is the key medicine of depressed liver-energy dispersing and QI regulating, can be used for all pain cards caused by irritability stasis." the southern regions of the Yunnan Province book on Chinese herbal medicine ": adjust the gas in blood, dissipating depression of QI, alleviating distention in middle-JIAO, helps digestion." book on Chinese herbal medicine is looked for the truth ": Rhizoma Cyperi, exclusive dissipating depression of QI falls apart gas, and with Radix Aucklandiae circulation of qi promoting, looks are with real different, and Radix Aucklandiae abnormal smells from the patient hardship is bad, therefore ventilation is very prompt, and this is then bitter and not very, therefore resolving depression is in the majority, and property and in the Radix Aucklandiae, therefore can add and subtract discrepancy, thinks circulation of qi promoting obstruction-removing prescription, otherwise should this and those ears unsuitable.
Radix Curcumae: be the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y. H. Chen et C. Ling, Rhizoma Curcumae Longae Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S. G. Lee et C. F. Liang or Rhizoma Curcumae Curcuma phaeocaulis Val..Nature and flavor: pungent, bitter, cold.Return liver, the heart, lung meridian.Effect: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice, removing heat from blood removing blood stasis with potent drugs.Cure mainly: all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.The pungent loose hardship of this product is let out, heat clearing away cold in nature, can have one's ideas straightened out by heart fire-clearing upset-relieving.Radix Curcumae pungent drugs can disperse and bitter drugs can descend, fragrance a surname reach, cold in nature again can heat clearing away.Both entered edema caused by disorder of QI with promoting QI circulation for relieving depression, entered again blood system with cooling blood and dissolving stasis, and be the gas medicine in blood, be used for the treatment of the chest pain of QI and blood stasis.
Herba Taxilli: be the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli Taxillus chinensis (DC.) Danser.Nature and flavor: bitter, sweet, flat.Return liver, kidney channel.Effect: invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit, Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening, the profit that nourishes blood muscle.
The Cortex Eucommiae: be the dry bark of the Eucommiaceae plant Cortex Eucommiae (Eucommia ulmoides Oliver).Nature and flavor: sweet, temperature.Return liver, kidney, stomach warp.Effect: liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, solid through antiabortive.Compendium of Material Medica: the Cortex Eucommiae, ancient prescription only knows nourishing kidney, and only Wang Haogu speech is Liver Channel edema caused by disorder of QI medicine, and profit liver is dry, and tonifying liver is empty, sends out former times people and does not send out also.Lid liver governing tendons, kidney governing bones, it is strong that kidney fills then bone, and liver is filled then muscle and is good for, and bends and stretches utilization, all belongs to muscle.
Semen Cuscutae: be the dry mature seed of dicotyledon scammonia section plant Semen Cuscutae Cuscuta chinensis Lam..Nature and flavor: sweet, warm.Return liver, kidney channel.Effect: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs is with urine, antiabortive, improving eyesight, antidiarrheal.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.Semen Cuscutae gets final product YANG invigorating, again can tonifying YIN, has temperature and not dry, and the feature of tonify without causing stagnation is the good medicine of flat invigorating the liver and kidney.Often join Fructus Lycii, Fructus Schisandrae Chinensis etc.The effect of Endocrine: Semen Cuscutae can increase hypothalamic-pituitary-ovarian and urge luteal function.
Semen Astragali Complanati: be the dry mature seed of leguminous plant astragatus complanatus Astragalus complanatus R.Brown..Nature and flavor: sweet, warm.Return liver, kidney channel.Effect: temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, improving eyesight.For lumbago due to renal deficiency, seminal emission premature ejaculation, nebulousurine leukorrhagia, dribbling urination, dizzy blurred vision." Gu Shi cures mirror " cloud: this product " special the kidney invigorating of reinforcing YIN-essence controlling nocturnal emission with astringent drugs, merit." Semen Astragali Complanati benefit essence and random sun, YANG invigorating and not random body.
Fructus Lycii: be the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Nature and flavor: sweet, flat.Return liver, kidney channel.Effect: nourishing the liver and kidney, replenishing vital essence to improve eyesight.Cure mainly: caused by liver and kidney deficiency; Have a dizzy spell; Visual unclear; Soreness of the waist and knees; Impotence and seminal emission; Cough due to consumptive disease; To quench one's thirst taking fluids profusely.Fructus Lycii contains the required nutrition of the healthy eye such as calcium, ferrum such as abundant carotene, retinol1, B1, B2, C, therefore is good at improving eyesight, so be commonly called as " bright eye ".The blurring of vision that ancient Chinese medicine doctor treatment deficiency of liver-blood, deficiency of kidney-YIN cause and nyctalopia, usually use Fructus Lycii.Fructus lycii extracted solution has delaying senility function and function for tonifying kidney.
Radix Achyranthis Bidentatae: be the root of Amaranthus mangostanus L. section herbaceos perennial Radix Achyranthis Bidentatae or RADIX CYATHULAE.Nature and flavor: bitter, sour, flat.Return liver, kidney channel.Effect: eliminating blood stasis and inducing menstruation, conducting blood to flow downwards, invigorating the liver and kidney, bone and muscle strengthening.Radix Achyranthis Bidentatae is apt to descending, and menstruation is unobstructed, normal urination, easyly greatly to rush down, and is easy to downward eliminating.
Fructus Corni: be the drying and ripening sarcocarp of Cornaceae plant Fructus Corni Cornus officinalis Sieb. et Zucc..Nature and flavor: sour, puckery, tepor.Return liver, kidney channel.Effect: liver and kidney tonifying, essence astringing and desertion stemming.Cure mainly and have a dizzy spell, deafness and tinnitus, soreness of the waist and knees, emission and spermatorrhea, frequent micturition, incessant sweating due to debility, woman uterine bleeding.Fructus Corni tepor is not dry, mends and not high, can flat nourishing YIN sun, supports the flourish muscle of marrow, by treating the liver kidney deficiency is commonly used.The sour-puckery flavor of Fructus Corni, can restrain solid de-, all gas body fluid persons of decoherencing, and available this product, with needed for card, is equipped with the same use of the medicine effected a permanent cure.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor: sweet, pungent, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Radix Angelicae Sinensis has inhibitory action to central nervous system, and volatile oil has the effects such as calmness, hypnosis, analgesia, anesthesia.For blood deficiency and yellow complexion, dizzy cardiopalmus, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores.Carry according to " book on Chinese herbal medicine is just ": " its sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, can support nutrition blood, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, nothing unsuitable." modern medicine study confirmation, Radix Angelicae Sinensis has antibacterial, antiinflammation.
Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Nature and flavor: pungent, temperature.Return liver, gallbladder, heart channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.The pungent loose temperature of this product is led to, can top, up mountain peak, assigns the sea of blood, outer thorough fur, bypass extremity, can invigorate blood circulation and can circulation of qi promoting, and it is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.Rhizoma Chuanxiong has obvious sedation.The in vitro testses such as antibacterial action: Rhizoma Chuanxiong has inhibitory action to large intestine, dysentery (Song Nei Shi), distortion, green pus, typhoid fever, Salmonella paratyphi and vibrio cholera etc.Rhizoma Chuanxiong water logging agent (1:3) also has inhibitory action to some pathogenic dermatophytes in vitro.
The Radix Paeoniae Alba: be the dry root of dicotyledon ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor: cool, picric acid, is slightly cold.Effect: easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing receives antiperspirant.This product energy nourishing the liver blood, holding back liver-yin, subduing the hyperfunction of the liver sun, dispersing liver-energy, can delay again that contraction is anxious, relieve the pain pain, is the good medicine of the various pain for the treatment of Liver Channel." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " purgation of spleen excess heat, only abdomen pain, sealing rushes down, and receives adverse flow of liver-QI pain, takes good care of conscience spleen channel blood, relax through sending down the abnormal ascending QI, only irritability pain." " herbal classic " Radix Paeoniae, though respectively in vain not red, the two is master to some extent respectively.So seek and unravel silk it and cure mainly all diseases, one is that replenishing blood and nourishing liver spleen is Kidney-Yin, and receives and take the photograph the at random of temper, and throwing off restraint of irritability is horizontal, then the Radix Paeoniae Alba.
Rhizoma Atractylodis Macrocephalae (parched): be the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor: bitter, sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive, the Rhizoma Atractylodis Macrocephalae can air making-up and spleen enlivening, again can dampness diuretic, is the key medicine of the spleen strengthening and damp drying.In the sweet temperature compensation of the Rhizoma Atractylodis Macrocephalae, can air making-up and spleen enlivening, also can strengthening superficial resistance to stop perspiration, and the Radix Astragali, Radix Pseudostellariae compatibility, play the merit of spleen reinforcing lung altogether.To rule together asthenia, the weak person of overstrain.
Radix Codonopsis: be the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis Codonopsis pilosula Nannf.var. modesta (Nannf.) L. T. Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Nature and flavor: sweet, flat.Return spleen, lung meridian.Effect: mend strengthening spleen and lung, nourishing blood to promote the production of body fluid.For deficiency of the spleen and lung, breathe hard, cardiopalmus, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst." Bencao Congxin " is recorded: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.Middle feeble QI is weak, mends in order to adjust, very smooth and proper." acid mucopolysaccharide in Radix Codonopsis has anticoagulant, can reduce blood fat and reduce blood viscosity and plasma viscosity, and have blood pressure lowering, blood fat reducing, antioxidation, defying age, improves the immunity of human body.
Semen Plantaginis: be the dry mature seed of Plantaginaceae plant Herba Plantaginis Plantago asiatica L. or Plantago depressa Willd Plantago depressa Willd..Nature and flavor: sweet, are slightly cold.Return liver, kidney, lung, small intestine meridian.Effect: clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, improving eyesight, eliminates the phlegm.For edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.
Fructus Ligustri Lucidi: be the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi Ligustrum lucidum Ait..Nature and flavor: bitter sweet, flat, nontoxic.Return liver, kidney, lung meridian.Effect: invigorating the liver and kidney, strong waist knee joint.Cure mainly: yin asthenia generating intrinsic heat, dizzy, order flower, tinnitus, soreness of the waist and knees, early whitening of beard and hair.Modern pharmacology is studied: Fructus Ligustri Lucidi can enhancing non-specific immunity function, has dual regulation to the immunologic function of exception; Rising effect is had to the leukopenia caused by chemotherapy and radiation; The serum cholesterol of laboratory animal can be reduced, have prevention and cut down atheromatous plaque and the effect alleviating plaque thickness, coronary atherosclerosis number can be reduced and alleviate its degree of congestion; Obviously can reduce mda content in Mus brain at advanced age, liver, improve superoxide dismutase (SOD) active, the certain defying age using value of tool; There are heart tonifying, diuresis, blood sugar lowering and hepatoprotective effect; And have cough-relieving, cathartic, antibacterial, antitumor action.
Cornu Cervi Degelatinatum: for Cornu Cervi removes photoresist the hornblock (boil Colla cornus cervi remaining bone slag) of matter.Nature and flavor: salty, warm.Return liver, kidney channel.Effect: warming the kidney to activate YANG, astringing to arrest bleeding.For spleen kidney yang flaccidity, lack of appetite and vomiting, leucorrhea, enuresis frequent micturition, metrostaxis, carbuncle sucutaneous nodule.
Colla Corii Asini: for the skin of equine species donkey Equus Asinus L. is through decocting, concentrating the solid gum made.Nature and flavor: sweet are flat.Return lung, liver, kidney channel.Effect: YIN nourishing of enriching blood, moisturizes, hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy." detailed outline ": Colla Corii Asini, will just enrich blood and liquid greatly, therefore can lung heat clearing tonifying YIN and control all cards.By Chen Ziming cloud: tonify deficiency animal glue, remove wind Colla Corii Asini.Cheng Wuji cloud: deficiency of YIN person, tonifying with drugs of thick flavor, Colla Corii Asini sweet, with nourishing YIN blood.Yang Shiying cloud: all control to breathe heavily cough, no matter the deficiency of the lung, excess of the lung, can under can temperature, palpus Colla Corii Asini is to pacify lung lung moistening, and its property is peaceful, is lung meridian key medicine.
Rhizoma Sparganii: be the dry tuber of Sparganiaceae plant Rhizoma Sparganii Spaganium stoloniferum Buch.-Ham..Nature and flavor: pungent, puckery, cool.Enter liver, spleen channel.Effect: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.Lump in the abdomen controlled by Chinese medicine, gathers, distending pain over the hypochondrium, food stagnation distending pain, dysmenorrhea, amenorrhea, and postnatal blood stasis is suffered from abdominal pain, traumatic injury.
Rhizoma Curcumae: be monocotyledon Zingiberaceae Zingiberaceae Rhizoma Curcumae Curcuma phaeocaulis Val., or RADIX CURCUMAE (also known as Curcuma wenyujin) C. wenyujin Y. H. Chen et C. Ling, the dry rhizome of Guangxi zedoary (also known as C. kwangsinensis) C.kwangsiensis S. lee et C. F. Liang.Nature and flavor: pungent, bitter, temperature.Return liver, spleen channel.Effect: removing blood stasis, promoting the circulation of QI to relieve pain.Often join Rhizoma Sparganii.Antibacterial action: Rhizoma Curcumae volatile oil in vitro can suppress staphylococcus aureus.The growth of beta hemolytic streptococcus, escherichia coli, Bacillus typhi, vibrio cholera etc.
Side's solution of the present invention is: in side, Radix Rehmanniae Preparata nourishing YIN and supplementing blood, beneficial essence fill out marrow, Rhizoma dioscoreae (parched) promotes the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission, Radix Dipsaci invigorating the liver and kidney, blood circulation regulating, Radix Bupleuri (processed with vinegar) dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang, Rhizoma Cyperi promoting QI circulation for relieving depression, menstruction regulating and pain relieving, Radix Curcumae regulating qi to disperse stagnation, heart fire-clearing upset-relieving, above Six-element is monarch drug altogether, fundamentally can carry out nourishing YIN and supplementing blood, beneficial essence fills out marrow, warm palace is carried out to the patient of premature ovarian failure and supports nest, menstruction regulating and pain relieving, increases the conditioning of body constitution, thus reaches the object of disease therapy.Herba Taxilli invigorating the liver and kidney, bone and muscle strengthening, Cortex Eucommiae bone and muscle strengthening, Chong and Ren Meridians regulating, Semen Cuscutae nourishing the liver and kidney, controlling nocturnal emission with astringent drugs are with urine, Semen Astragali Complanati temperature compensation Liver and kidney, Fructus Lycii nourishing the liver and kidney, replenishing vital essence to improve eyesight, Radix Achyranthis Bidentatae eliminating blood stasis and inducing menstruation, conducting blood to flow downwards, Fructus Corni liver and kidney tonifying, essence astringing and desertion stemming, above seven tastes are ministerial drug altogether, while assisting a ruler in governing a country monarch drug, also there is nourishing ovary, balance estrogen and progestogen, life lengthening, reaches the economic benefits and social benefits for the treatment of both the principal and secondary aspects of a disease.Radix Angelicae Sinensis, Rhizoma Chuanxiong blood-activating and qi-promoting, the Radix Paeoniae Alba is enriched blood easing the affected liver, suppressing the hyperactive liver pain relieving, Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI, dampness diuretic, Radix Codonopsis mends strengthening spleen and lung, nourishing blood to promote the production of body fluid, Semen Plantaginis clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, Fructus Ligustri Lucidi invigorating the liver and kidney, Cornu Cervi Degelatinatum warming the kidney to activate YANG, astringing to arrest bleeding, Colla Corii Asini nourishing blood YIN nourishing, Rhizoma Sparganii, the circulation of qi promoting of Rhizoma Curcumae removing blood stasis, removing food stagnancy pain relieving, a few taste is adjuvant drug altogether above, increase while drug effect, do not forget nourishing YIN for suppressing the hyperactive YANG, YIN nourishing of enriching blood, strengthen the body constitution of patient, increase the resistance of patient, and then accelerate patient's improvement.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, have nourishing YIN and supplementing blood, effect that beneficial essence fills out marrow, supplementing QI for promoting the production of body fluid, promoting QI circulation for relieving depression, effectively can treat premature ovarian failure.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Rehmanniae Preparata 13-23 part, Rhizoma dioscoreae (parched) 10-20 part, Radix Dipsaci 15-25 part, Radix Bupleuri (processed with vinegar) 7-17 part, Rhizoma Cyperi 7-17 part, Radix Curcumae 10-20 part, Herba Taxilli 13-23 part, Cortex Eucommiae 13-23 part, Semen Cuscutae 15-25 part, Semen Astragali Complanati 15-25 part, Fructus Lycii 15-25 part, Radix Achyranthis Bidentatae 10-20 part, Fructus Corni 5-15 part, Radix Angelicae Sinensis 10-20 part, Rhizoma Chuanxiong 7-17 part, Radix Paeoniae Alba 10-20 part, Rhizoma Atractylodis Macrocephalae (parched) 13-23 part, Radix Codonopsis 10-20 part, Semen Plantaginis 13-23 part, Fructus Ligustri Lucidi 10-20 part, Cornu Cervi Degelatinatum 7-17 part, Colla Corii Asini 2-8 part, Rhizoma Sparganii 10-20 part, Rhizoma Curcumae 10-20 part.
Wherein be preferably: Radix Rehmanniae Preparata 18 parts, Rhizoma dioscoreae (parched) 15 parts, Radix Dipsaci 20 parts, Radix Bupleuri (processed with vinegar) 12 parts, Rhizoma Cyperi 12 parts, Radix Curcumae 15 parts, Herba Taxilli 18 parts, the Cortex Eucommiae 18 parts, Semen Cuscutae 20 parts, Semen Astragali Complanati 20 parts, Fructus Lycii 20 parts, Radix Achyranthis Bidentatae 15 parts, Fructus Corni 10 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Chuanxiong 12 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 18 parts, Radix Codonopsis 15 parts, Semen Plantaginis 18 parts, Fructus Ligustri Lucidi 15 parts, Cornu Cervi Degelatinatum 12 parts, 5 parts, Colla Corii Asini, Rhizoma Sparganii 15 parts, Rhizoma Curcumae 15 parts.
Medicine of the present invention can adopt the conventional fabrication process of Chinese medicine preparation, can be made into said dosage form on any one pharmaceutics, as pill, powder, tablet, capsule, granule, syrup, oral liquid etc.Such as these crude drug grind into fine powder mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.
The preferred preparation method of the present invention is decoction, and its preparation method is as follows:
Step one: by weight proportion of the present invention, first becomes medicated bag by Semen Cuscutae, Semen Astragali Complanati, Fructus Lycii, Semen Plantaginis, Fructus Ligustri Lucidi bundle, is put in water and soaks 40-45 minute, filters, for subsequent use;
Step 2: by weight proportion of the present invention, by Radix Rehmanniae Preparata, Rhizoma dioscoreae (parched), Radix Bupleuri (processed with vinegar), the air-dry pulverizing of Rhizoma Atractylodis Macrocephalae (parched), grinds into powder to 180 mesh sieves, for subsequent use;
Step 3: by weight proportion of the present invention, take Radix Dipsaci, Rhizoma Cyperi, Radix Curcumae, Radix Achyranthis Bidentatae, the Radix Paeoniae Alba, Radix Codonopsis put into marmite, add after soaking in step one and remain cold water, exceed powder 2-5 centimetre, after being fried boiling with high heat, again with 20-30 minute at a simmer, filter, obtain filtrate, in residue medicinal residues, add the water of 3-4 centimetre, then the medicated bag added in Herba Taxilli, the Cortex Eucommiae, Fructus Corni, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Sparganii, Rhizoma Curcumae and step one decocts 20-30 minute, filter, obtain filtrate, merge twice filtrate, waste, for subsequent use;
Step 4: by weight proportion of the present invention, takes in the hot soup that Cornu Cervi Degelatinatum and Colla Corii Asini be put in step 3 while hot and carries out molten, then add step 2 gained fine powder, mix homogeneously, both the Chinese medicine decoction for the treatment of premature ovarian failure of the present invention.
Effect that medicine of the present invention has nourishing YIN and supplementing blood, beneficial essence fills out marrow, supplementing QI for promoting the production of body fluid, promoting QI circulation for relieving depression, and have good effect for improving ovarian function, patient's body constitution can be strengthened, and have cheap, and the feature of nontoxic pair, the mode that this Chinese medicine preparation adopts is treated and can be reduced the injury to patient body such as Western medicine hormone, alleviate the slight illness of patient, according to clinical 60 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 81.7%, two the total effective rate course for the treatment of 95%.
Detailed description of the invention
Embodiment one, Radix Rehmanniae Preparata 13 parts, Rhizoma dioscoreae (parched) 10 parts, Radix Dipsaci 15 parts, Radix Bupleuri (processed with vinegar) 7 parts, Rhizoma Cyperi 7 parts, Radix Curcumae 10 parts, Herba Taxilli 13 parts, the Cortex Eucommiae 13 parts, Semen Cuscutae 15 parts, Semen Astragali Complanati 15 parts, Fructus Lycii 15 parts, Radix Achyranthis Bidentatae 10 parts, Fructus Corni 5 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Chuanxiong 7 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Atractylodis Macrocephalae (parched) 13 parts, Radix Codonopsis 10 parts, Semen Plantaginis 13 parts, Fructus Ligustri Lucidi 10 parts, Cornu Cervi Degelatinatum 7 parts, 2 parts, Colla Corii Asini, Rhizoma Sparganii 10 parts, Rhizoma Curcumae 10 parts.
Embodiment two, Radix Rehmanniae Preparata 18 parts, Rhizoma dioscoreae (parched) 15 parts, Radix Dipsaci 20 parts, Radix Bupleuri (processed with vinegar) 12 parts, Rhizoma Cyperi 12 parts, Radix Curcumae 15 parts, Herba Taxilli 18 parts, the Cortex Eucommiae 18 parts, Semen Cuscutae 20 parts, Semen Astragali Complanati 20 parts, Fructus Lycii 20 parts, Radix Achyranthis Bidentatae 15 parts, Fructus Corni 10 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Chuanxiong 12 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 18 parts, Radix Codonopsis 15 parts, Semen Plantaginis 18 parts, Fructus Ligustri Lucidi 15 parts, Cornu Cervi Degelatinatum 12 parts, 5 parts, Colla Corii Asini, Rhizoma Sparganii 15 parts, Rhizoma Curcumae 15 parts.
Embodiment three, Radix Rehmanniae Preparata 23 parts, Rhizoma dioscoreae (parched) 20 parts, Radix Dipsaci 25 parts, Radix Bupleuri (processed with vinegar) 17 parts, Rhizoma Cyperi 17 parts, Radix Curcumae 20 parts, Herba Taxilli 23 parts, the Cortex Eucommiae 23 parts, Semen Cuscutae 25 parts, Semen Astragali Complanati 25 parts, Fructus Lycii 25 parts, Radix Achyranthis Bidentatae 20 parts, Fructus Corni 15 parts, Radix Angelicae Sinensis 20 parts, Rhizoma Chuanxiong 17 parts, the Radix Paeoniae Alba 20 parts, Rhizoma Atractylodis Macrocephalae (parched) 23 parts, Radix Codonopsis 20 parts, Semen Plantaginis 23 parts, Fructus Ligustri Lucidi 20 parts, Cornu Cervi Degelatinatum 17 parts, 8 parts, Colla Corii Asini, Rhizoma Sparganii 20 parts, Rhizoma Curcumae 20 parts.
Here is the clinical statistics data that patient uses medicine of the present invention:
One, physical data
Accept out-patient 120 example for medical treatment, patient is divided into observation group and matched group at random, wherein 36 years old mean age, the course of disease time is not etc., two groups of every basic documents such as patient age, the course of disease are substantially identical, no significant difference (P > 0.05).
Two, Therapeutic Method:
1, according to Medications Example two of the present invention, and preparation prepared by selected preparation method, weighting raw materials (daily dose), filter and remove residue after decocting, services once, decoction being taken warmly sooner or later.It within 30 days, is a course for the treatment of.
2, matched group conveniently Therapeutic Method, oral western medicine is treated, and the observation period is 30 days.
Three, efficacy assessment standard:
1, effective: clinical symptoms all disappears, menstrual cycle and all normal through amount, all are normal for lab testing, within three months, have no recurrence;
2, effective: clinical symptom relief, the state of an illness is controlled, and lab testing improves gradually;
3, invalid: clinical symptoms even increases the weight of without being clearly better.
Four, observation group's result statistics
Matched group result is added up
Wherein: total effective rate=obvious effective rate+effective percentage
Use the Comparison of therapeutic situation of this Chinese medicine preparation two groups of patients, two courses for the treatment of
Can find that observation group is apparently higher than matched group by the treatment total effective rate contrasting two groups of patients, illustrate thus, Chinese medicine of the present invention has good clinical effectiveness at treatment premature ovarian failure, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.
Model case and curative effect:
Case one, grandson patient, female, 34 years old, before half a year, menstruation is always abnormal, two or three months once, and through measuring rareness, often there is insomnia and dreamful sleep in patient, tired, the symptoms such as agitation, patient removes examination in hospital, be diagnosed as premature ovarian failure, patient is unwilling long-term steroid class medicine, determine to adopt treatment by Chinese herbs method, adopt made preparation in the embodiment of the present invention two, and selected preparation method, after patient takes a course for the treatment of, menstrual onset, also increased than in the past through amount, patient holds on and takes two courses for the treatment of, menstruation recovery is normal, sleep quality improves, energetic, body constitution also must be with improvement, the colour of skin becomes clear, Effect of follow-up visit by telephone three months, menstruation is always normal, recovery from illness.
Case two, patient Wu, female, 33 years old, patient is always abnormal for nearly 1 year menstrual period, a menstruation over several months, and it is fewer and feweri through measuring, patient goes to hospital to check, be diagnosed as premature ovarian failure, adopt made preparation in the embodiment of the present invention two, and selected preparation method, patient's menstrual onset after the course for the treatment of, through amount showed increased, patient continues to take two courses for the treatment of, menstrual cycle and all move closer to normal through amount, complexion is clearly better, sleep quality improves, body constitution obviously strengthens, Effect of follow-up visit by telephone three months, menstrual period, always normal through amount, recovery from illness.
Case three, patient's fourth, female, 30 years old, patient's menolipsis two months, originally think it is conceived, but often have a sleepless night recently always, look pale, patient goes to hospital to check, find not conceived, carry out comprehensive health check-up again, be diagnosed as premature ovarian failure, patient adopts made preparation in the embodiment of the present invention two, and selected preparation method, patient's menstrual onset after the course for the treatment of, normal through measuring, patient continues to take a course for the treatment of, menstrual cycle and through amount all normal, complexion is clearly better, sleep quality improves, body constitution obviously strengthens, Effect of follow-up visit by telephone three months, all are normal, recovery from illness.
Claims (4)
1. treat the Chinese medicine preparation of premature ovarian failure for one kind, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Radix Rehmanniae Preparata 13-23 part, Rhizoma dioscoreae (parched) 10-20 part, Radix Dipsaci 15-25 part, Radix Bupleuri (processed with vinegar) 7-17 part, Rhizoma Cyperi 7-17 part, Radix Curcumae 10-20 part, Herba Taxilli 13-23 part, Cortex Eucommiae 13-23 part, Semen Cuscutae 15-25 part, Semen Astragali Complanati 15-25 part, Fructus Lycii 15-25 part, Radix Achyranthis Bidentatae 10-20 part, Fructus Corni 5-15 part, Radix Angelicae Sinensis 10-20 part, Rhizoma Chuanxiong 7-17 part, Radix Paeoniae Alba 10-20 part, Rhizoma Atractylodis Macrocephalae (parched) 13-23 part, Radix Codonopsis 10-20 part, Semen Plantaginis 13-23 part, Fructus Ligustri Lucidi 10-20 part, Cornu Cervi Degelatinatum 7-17 part, Colla Corii Asini 2-8 part, Rhizoma Sparganii 10-20 part, Rhizoma Curcumae 10-20 part.
2. the Chinese medicine preparation for the treatment of premature ovarian failure according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Radix Rehmanniae Preparata 18 parts, Rhizoma dioscoreae (parched) 15 parts, Radix Dipsaci 20 parts, Radix Bupleuri (processed with vinegar) 12 parts, Rhizoma Cyperi 12 parts, Radix Curcumae 15 parts, Herba Taxilli 18 parts, the Cortex Eucommiae 18 parts, Semen Cuscutae 20 parts, Semen Astragali Complanati 20 parts, Fructus Lycii 20 parts, Radix Achyranthis Bidentatae 15 parts, Fructus Corni 10 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Chuanxiong 12 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 18 parts, Radix Codonopsis 15 parts, Semen Plantaginis 18 parts, Fructus Ligustri Lucidi 15 parts, Cornu Cervi Degelatinatum 12 parts, 5 parts, Colla Corii Asini, Rhizoma Sparganii 15 parts, Rhizoma Curcumae 15 parts.
3. the Chinese medicine preparation for the treatment of premature ovarian failure according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.
4. treat the preparation method of the Chinese medicine preparation of premature ovarian failure for one kind, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, first Semen Cuscutae, Semen Astragali Complanati, Fructus Lycii, Semen Plantaginis, Fructus Ligustri Lucidi bundle are become medicated bag, be put in water and soak 40-45 minute, filter, for subsequent use; Step 2: by weight proportion of the present invention, by Radix Rehmanniae Preparata, Rhizoma dioscoreae (parched), Radix Bupleuri (processed with vinegar), the air-dry pulverizing of Rhizoma Atractylodis Macrocephalae (parched), grinds into powder to 180 mesh sieves, for subsequent use; Step 3: by weight proportion of the present invention, take Radix Dipsaci, Rhizoma Cyperi, Radix Curcumae, Radix Achyranthis Bidentatae, the Radix Paeoniae Alba, Radix Codonopsis put into marmite, add after soaking in step one and remain cold water, exceed powder 2-5 centimetre, after being fried boiling with high heat, again with 20-30 minute at a simmer, filter, obtain filtrate, in residue medicinal residues, add the water of 3-4 centimetre, then the medicated bag added in Herba Taxilli, the Cortex Eucommiae, Fructus Corni, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Sparganii, Rhizoma Curcumae and step one decocts 20-30 minute, filter, obtain filtrate, merge twice filtrate, waste, for subsequent use; Step 4: by weight proportion of the present invention, takes in the hot soup that Cornu Cervi Degelatinatum and Colla Corii Asini be put in step 3 while hot and carries out molten, then add step 2 gained fine powder, mix homogeneously, both the Chinese medicine decoction for the treatment of premature ovarian failure of the present invention.
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| CN105169151A (en) * | 2015-11-03 | 2015-12-23 | 强红枫 | Application of camellia cuspidate-peony flower in preparation of medicine for preventing and treating complications after hysterectomy |
| CN105816660A (en) * | 2016-04-27 | 2016-08-03 | 皖南医学院 | Oral thick paste with effect of maintaining ovaries and preparation method thereof |
| CN109966407A (en) * | 2019-05-08 | 2019-07-05 | 普洱市中医医院 | Train first live-nourishing ' yanggan ' pill |
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| CN115137715A (en) * | 2022-06-24 | 2022-10-04 | 香港大学深圳医院 | Application of curcumin in preparation of medicine for treating premature ovarian insufficiency and ovarian response deficiency |
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| CN104906526A (en) * | 2015-07-14 | 2015-09-16 | 孙海玲 | Chinese medicine preparation for premature ovarian failure and preparation method of Chinese medicine preparation |
| CN105169151A (en) * | 2015-11-03 | 2015-12-23 | 强红枫 | Application of camellia cuspidate-peony flower in preparation of medicine for preventing and treating complications after hysterectomy |
| CN105816660A (en) * | 2016-04-27 | 2016-08-03 | 皖南医学院 | Oral thick paste with effect of maintaining ovaries and preparation method thereof |
| CN109966407A (en) * | 2019-05-08 | 2019-07-05 | 普洱市中医医院 | Train first live-nourishing ' yanggan ' pill |
| CN109966407B (en) * | 2019-05-08 | 2021-11-05 | 普洱市中医医院 | Vitality-cultivating and liver-nourishing pill |
| KR20210043788A (en) * | 2019-10-11 | 2021-04-22 | 대전대학교 산학협력단 | Pharmacentical composition of JBD composition and method of analyzing ovarian function |
| KR102287423B1 (en) * | 2019-10-11 | 2021-08-10 | 대전대학교 산학협력단 | Pharmacentical composition of JBD composition and method of analyzing ovarian function |
| WO2022086042A1 (en) * | 2020-10-20 | 2022-04-28 | 한국 한의학 연구원 | Composition for prevention, amelioration or treatment of poor ovarian responders caused by aging, comprising mixed medicinal herb extract as active ingredient |
| CN115137715A (en) * | 2022-06-24 | 2022-10-04 | 香港大学深圳医院 | Application of curcumin in preparation of medicine for treating premature ovarian insufficiency and ovarian response deficiency |
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