CN105816617A - Traditional Chinese medicine composition for treating obesity type polycystic ovarian syndrome - Google Patents

Traditional Chinese medicine composition for treating obesity type polycystic ovarian syndrome Download PDF

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CN105816617A
CN105816617A CN201610281153.7A CN201610281153A CN105816617A CN 105816617 A CN105816617 A CN 105816617A CN 201610281153 A CN201610281153 A CN 201610281153A CN 105816617 A CN105816617 A CN 105816617A
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rhizoma
chinese medicine
medicine composition
obesity
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石敏
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Shandong Provincial Hospital
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Shandong Provincial Hospital
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296Epimedium
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    • A61K36/39Convolvulaceae (Morning-glory family), e.g. bindweed
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/746Morinda
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/88Liliopsida (monocotyledons)
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    • A61K36/8888Pinellia
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    • A61K36/88Liliopsida (monocotyledons)
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)

Abstract

The invention provides a traditional Chinese medicine composition for treating an obesity type polycystic ovarian syndrome. The traditional Chinese medicine composition is prepared from, by weight, 9-12 parts of rhizoma pinelliae, 10-15 parts of cassia twigs, 7-10 parts of rhizoma atractylodis, 10-20 parts of rhizoma cyperi, 10-20 parts of exocarpium citri rubrum, 10-20 parts of herba epimedii, 8-12 parts of radix morindae officinalis, 10-20 parts of rhizoma chuanxiong and 10-15 parts of roasted fructus aurantii immaturus. In the formula, rhizoma pinelliae, rhizoma atractylodis and exocarpium citri rubrum strengthen the spleen, dry dampness and reduce phlegm, rhizoma cyperi warms the meridians for promoting coronary circulation and regulates menstruation to relieve pain, herba epimedii and radix morindae officinalis replenish kidney yang and strengthen muscles and bones, rhizoma chuanxiong and fructus aurantii immaturus promote qi circulation and eliminate stagnation, and all the medicinal materials are used together to jointly achieve the effects of invigorating the spleen and the kidney, reducing phlegm and promoting urination and promoting qi circulation to regulate menstruation. The reproductive axis can be normally started if kidney qi is enough, the uterus can recover the normal physiological cycle if phlegm turbidity is removed, follicles can be smoothly discharged, menstruation can come at the appointed time, embryo gestating can be achieved, and the effect of treating the obesity type polycystic ovarian syndrome is significant. Not only that, the traditional Chinese medicine composition also has the effects of improving reproductive internal secretion of organisms, reducing blood glucose and blood lipid and losing weight.

Description

A kind of Chinese medicine composition treating Obesity-type Polycystic Ovary Syndrome
Technical field
The present invention relates to a kind of Chinese medicine composition treating Obesity-type Polycystic Ovary Syndrome, belong to Chinese medicine neck Territory.
Background technology
Polycystic ovarian syndrome (polycystic ovary syndrome, PCOS) be with hyperandrogenism, The syndrome that ovulation failure and polycystic ovary are characterized.In adolescence and Female in child bearing period, sickness rate is relatively for it Height, for 5%-10%, accounts for the 50%-70% of the most ovulatory infertility, wherein shows as overweight people and accounts for 50%, and Based on abdominal obesity (central obesity), because this patient's menoxenia, infertile, fat, hirsutism etc. are near Phase is perplexed and the risk of the multiple long term complications such as diabetes, cardiovascular disease and carcinoma of endometrium occurs, becomes For affecting one of physically and mentally healthy most common and most important disease with quality of life of women.
Obesity is an important clinical performance of PCOS, and modern medicine study shows, PCOS ob esity's symptom Generation and PCOS disease development reciprocal causation.The free testosterone that PCOS increases in the patient can strengthen α-adrenergic Anti-lipolytic effect, thus cause fat generation.During the most internal a large amount of androgen, Sex hormone binding globulin expression declines, the free androgen of increase and the androgen receptor in fatty tissue Combine, be adipose cell division, fat growth, triglyceride (TG) storage.And abdominal part and internal organs fat Accumulation also can further result in the generation of hyperandrogenism, both interact, and mutually promote so that pernicious Circulation.
Traditional Chinese Medicine is thought, menstruation is-kidney-sky decyl-punching appoints-effect of uterus Reproductive Axis, be menses, internal organs dirty, QI and blood, meridians coordinative role are in the physiological phenomenon of uterus.Fu Qingzhu speech " through this in kidney ", " going out all kidneys through water ". Illustrate that the material source of menstruation is originally in kidney.POCS patient or because of congenital deficiency of kidney-QI, or because damaging spleen kidney the day after tomorrow, Normal cause stagnation of phlegm-damp punching is appointed, and stops up stagnant uterus, has upset the physiological action of kidney-sky decyl-punching times-uterus, the moon has occurred Through dilute, amenorrhea.Phlegm-dampness constitution person has itself can damage kidney yang, the two reciprocal causation.Phlegm-damp is mark.Facing On bed, most of PCOS patients have menstrual cycle to delay, hypomenorrhea, in appearance body are plentiful or fat, breast Vexed nausea, spirit is sleepy, and heavy sensation of the body is not well, and to have skin of face oils and fats concurrently more more, and complexion is yellowish and dark, many Antiperspirant and viscous, many sputums in larynx, profuse leukorrhea, matter is dilute, and light red tongue is fat greatly, and tongue is the most greasy, rolling pulse or heavy sliding etc. special Sex expression.Phlegm-damp travels round whole body with gas, is detained and then produces different pathological changes at different internal organs, and phlegm-damp is exuberant Skin then patient's obesity, hirsutism;Phlegm-damp cohesion adipose membrane then ovary presents many capsules sample and changes;Phlegm-damp is detained punching Appointing uterus then menstrual cycle to delay, even amenorrhea, these 3 is the typical clinical manifestation of PCOS patient.So It is that primary disease is main and most important Therapeutic Principle that the kidney invigorating is reduced phlegm.
The Therapeutic Method of PCOS is mainly had by modern medicine: western medicine, operative treatment, Chinese traditional treatment etc.. Western medicine has certain dependency, and after drug withdrawal, symptom is the most repeatedly, and operation has the risk etc. that attachment area adhesion occurs.And Chinese medicine can integrally-regulated organism endocrine function, few side effects.As CN104162057A relates to one The Chinese medicine composition for the treatment of Obesity-type Polycystic Ovary Syndrome, described Chinese medicine composition includes following crude drug: Radix Angelicae Sinensis, the Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Curculiginis, Herba Epimedii, Fructus Ligustri Lucidi, Folium Photiniae (Folium Photiniae serrulatae), Carapax Trionycis, Radix Salviae Miltiorrhizae, Cortex Moutan, system perfume Attached, Poria, Flos Caryophylli (under Hou), Rhizoma Acori Graminei, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Pinelliae Preparata, Fructus Hordei Germinatus, Jiao Liuqu, life Fructus Crataegi.And add Radix Bupleuri, Herba Leonuri in premenstruum, add Ramulus Cinnamomi, Fructus Liquidambaris the onset of ovulation, add postmenstruation Cornu Cervi tablet, Fluoritum, Radix Morindae Officinalis.It is an advantage of the current invention that: this Chinese medicine composition the kidney invigorating is reduced phlegm, increase fertilizer can be played Fat PCOS adiponectin level and improve the effect of insulin resistant of this type of patient.CN104162 094A discloses a kind of Chinese medicine composition treating Obesity-type Polycystic Ovary Syndrome and pharmaceutical preparation thereof, by such as The crude drug composition of lower weight portion: Atractylis chinensis 6-15 part, Massa Medicata Fermentata 6-15 part, Rhizoma Cyperi 6-15 part, Rhizoma Zingiberis Recens half Summer 6-15 part, Poria 6-15 part, Radix Angelicae Sinensis 9-30 part, Fructus Lycii 10-30 part, Fructus Mori 10-20 part, Radix Curcumae 6-15 part, Flos Rosae Rugosae 6-15 part, Spina Gleditsiae 10-30 part, Spica Prunellae 10-30 part, Sargassum 10-30 Part, Rhizoma Acori Graminei 10-30 part, Rhizoma Curcumae 10-20 part, Radix Cyathulae 10-20 part, Radix Scutellariae (parched) 9-15 part.Should Chinese medicine composition can effectively treat Obesity-type Polycystic Ovary Syndrome and side effect is little, relapse rate is low.But mesh Before still do not have pertinent literature to report the present invention treats the Chinese medicine composition of Obesity-type Polycystic Ovary Syndrome.
Summary of the invention
It is an object of the invention to the deficiency overcome in traditional treatment, it is provided that one is treated obese type polycystic ovary and combined The Chinese medicine composition of simulator sickness.
Technical solution of the present invention is as follows: a kind of Chinese medicine composition treating Obesity-type Polycystic Ovary Syndrome, with weight Amount part meter, including the crude drug of following component: Rhizoma Pinelliae 9-12 part, Ramulus Cinnamomi 10-15 part, Rhizoma Atractylodis 7-10 part, Rhizoma Cyperi 10-20 part, Exocarpium Citri Rubrum 10-20 part, Herba Epimedii 10-20 part, Radix Morindae Officinalis 8-12 part, Rhizoma Chuanxiong 10-20 Part, Fructus Aurantii Immaturus (parched) 10-15 part.
Preferably, a kind of Chinese medicine composition treating Obesity-type Polycystic Ovary Syndrome of the present invention, in parts by weight, Crude drug including following component: the Rhizoma Pinelliae 9 parts, Ramulus Cinnamomi 12 parts, Rhizoma Atractylodis 9 parts, Rhizoma Cyperi 15 parts, Exocarpium Citri Rubrum 15 parts, Herba Epimedii 15 parts, Radix Morindae Officinalis 10 parts, Rhizoma Chuanxiong 15 parts, Fructus Aurantii Immaturus (parched) 12 parts.
The present inventor's research thinks that the kidney invigorating Circulation Resolving Phlegm is the primary therapy of phlegm-damp type PCOS patient of suffering from a deficiency of the kidney, and PCOS suffers from Person is with kidney asthenia as the principal aspect, phlegm-damp for target dysgenesia disease, and possible natural endowment is not enough, or takes contraception for a long time Medicine, spleen kidney deficiency, disturbance in functioning of QI, water-damp not being transformed, for a long time impairment of YANG gas.Deficiency of spleen-YANG and kidneyYANG, is not enough to temperature palace.Palace Cold blood stasis, and arrive opsomenorrhea and close, amenorrhea and infertile;Deficiency of spleen-YANG and kidneyYANG, dampness expectorant is solidifying and fat, dampness blood stasis and To aversion to cold and cold limbs, edema hirsutism, the whole body is tired heavily waits disease.Therefore answer righting (the kidney invigorating) in treatment, uncharm and (change Expectorant), because of " sick phlegm retention person, when with temperature medicine and it ", equilibrium between yin and yang to be focused on.Phlegm-damp is the mark of primary disease, Eliminating the phlegm wet heresy, must give wet method of reducing phlegm, in side, the Rhizoma Pinelliae, Rhizoma Atractylodis, Exocarpium Citri Rubrum the spleen strengthening and damp drying reduce phlegm, Ramulus Cinnamomi, perfume (or spice) Attached warming the meridian and promoting blood circulation menstruction regulating and pain relieving, Herba Epimedii, Radix Morindae Officinalis kidney-replenishing bone and muscle strengthening, Rhizoma Chuanxiong, Fructus Aurantii Immaturus circulation of qi promoting disappear stagnant, all Medicine share plays strengthening spleen, tonifying kidney altogether, the diuretic that reduces phlegm, the effect of circulation of qi promoting regulating menstruation.The kidney qi foot then normal startup of Reproductive Axis gram, Expectorant is turbid to be gone, and uterus can recover the normal physiological cycle, and follicle is got rid of smooth and easy, and menstruation can come at the appointed time, and tire is pregnant. Moreover, the present invention also can improve body reproductive endocrine, reduces blood glucose, blood fat, reduces the effect of body weight.
For improving therapeutic effect further, can be according to the physiological characteristics opinion of women menses wane and wax of yin and yang transformation rule Control: add Cornu Cervi tablet 5-16 part, Fluoritum 10-15 part premenstruum with kidney-replenishing;Add Herba Leonuri 10-20 menstrual period Part, Radix Bupleuri 10-20 part, Radix Salviae Miltiorrhizae 10-30 part, Herba Lycopi's 10-20 part, add the onset of ovulation Semen Cuscutae 5-10 part, Radix Angelicae Sinensis 10-20 part, with the kidney invigorating QI and blood regulating induced ovulation, adds Rhizoma Dioscoreae 9-15 part, Rhizoma Polygonati 9-15 part, Radix Rehmanniae Preparata postmenstruation Yellow 9-15 part is with tonifying kidney-yin.
Preparation method: medical material clear water soaks half an hour, after big fire is boiled, then slow fire boiling 20 minutes, take Head is decocted, and adds water decoction 15 minutes, takes two and decocts, and two decoct and even, point sooner or later takes for twice, every day potion, It serve on 3 months.
The present invention also provide for the Chinese medicine composition of above-mentioned Obesity-type Polycystic Ovary Syndrome in preparation prevention and/or Application in the medicine for the treatment of Obesity-type Polycystic Ovary Syndrome.
In side of the present invention, the pharmacological action of each crude drug is as follows:
The Rhizoma Pinelliae: pungent, temperature;Poisonous.Return spleen, stomach, lung meridian.Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass. For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and vomits regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.
Ramulus Cinnamomi: acrid, sweet, warm.GUIXIN, lung, bladder warp.Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, The flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, Renal mass.
Rhizoma Atractylodis: pungent, bitter, temperature.Return spleen, stomach, Liver Channel.Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For gastral cavity Distention and fullness in the abdomen, has loose bowels, edema, tinea pedis flaccidity, rheumatic arthralgia, anemofrigid cold, nyctalopia.
Rhizoma Cyperi: hardship pungent, micro-, micro-sweet, flat.Return liver, spleen, tri-jiao channel.Promoting QI circulation for relieving depression, menstruction regulating and pain relieving.With In stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, Menoxenia, amenorrhea dysmenorrhea.
Exocarpium Citri Rubrum: pungent, bitter, temperature.Return lung, spleen channel.Cold expelling, dampness, promoting the circulation of QI, expectorant.For cough due to wind and cold, Itching of the throat abundant expectoration, food stagnation gets sick from drinking too much wine, and vomiting and nausea painful abdominal mass is vexed.
Herba Epimedii: acrid, sweet, warm.Return liver, kidney channel.Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Lose for sexual impotence Essence, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture;Climacteric hypertension.
Radix Morindae Officinalis: sweet, pungent, tepor.Return kidney, Liver Channel.Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For sexual impotence Seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.
Rhizoma Chuanxiong: pungent, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, Amenorrhea dysmenorrhea, lump in the abdomen stomachache, breast side of body twinge, tumbling and swelling, headache, rheumatic arthralgia.
Fructus Aurantii Immaturus: bitter, pungent, sour, temperature.Return spleen, stomach warp.Dispelling the stagnated QI removing food stagnancy, scattered painful abdominal mass of reducing phlegm.Stop in stagnant, Feeling of fullness distending pain, weight, constipation, the expectorant stagnant vapour lock thoracic obstruction, blocked-up chest after dysentery;Gastroptosis, proctoptosis, uterus takes off Hang down.
Fluoritum: sweet, temperature.GUIXIN, lung, kidney channel.Tranquilizing mind, warming the lung, warm palace.For insomnia and dreamful sleep, Palpitation and being susceptible to fright, cough and asthma due to lung deficiency, infertility.
Cornu Cervi: salty, temperature.Return liver, kidney channel.The kidney warming sun, bone and muscle strengthening, promoting the circulation of blood is subsided a swelling.For impotence and seminal emission, Spinal column cold type of pain, carbuncle of yin nature skin infection, acute mastitis is from the beginning of, swelling and pain due to blood stasis.
Herba Leonuri: bitter, pungent, is slightly cold.Return liver, pericardium channel.Promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menstruation not Adjust, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria;Acute nephritis edema.
Radix Bupleuri: bitter, is slightly cold.Return liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, cold Heat contact, distending pain in the chest and hypochondrium, menoxenia, sub-official prolapses, proctoptosis.
Radix Salviae Miltiorrhizae: bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menstruation Uncomfortable, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia;Liver spleen Enlargement, angina pectoris.
Herba Lycopi: bitter, pungent, tepor.Return liver, spleen channel.Blood circulation promoting and blood stasis dispelling, line water detumescence.For menoxenia, Amenorrhea, dysmenorrhea, postnatal blood stasis stomachache, edema.
Semen Cuscutae: sweet, temperature.Return liver,kidney,spleen warp.Nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, only Rush down.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, tire Dynamic uneasiness, spleen is suffered from a deficiency of the kidney and is rushed down;Externally treating leucoderma.
Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation.With In blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, Injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Rhizoma Dioscoreae: sweet, flat.Return spleen, lung, kidney channel.Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For spleen Empty lack of appetite, incessant chronic diarrhea, the deficiency of the lung breathes with cough, and emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) is mended Spleen stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Rhizoma Polygonati: sweet is flat.Return spleen, lung, kidney channel.Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For taste Weakness, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.
Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.Nourishing YIN and supplementing blood, benefit essence fills out marrow.For the hepatic and renal YIN deficiency, waist Knees soreness, osteopyrexia and fever, night sweat passes out semen, and interior-heat quenches one's thirst, blood deficiency and yellow complexion, severe palpitation, and menoxenia is collapsed Leak down blood, dizziness, tinnitus, early whitening of beard and hair.
It is evident in efficacy that the present invention treats Obesity-type Polycystic Ovary Syndrome, and effective percentage reaches 92.5%, and without any Side effect.Below in conjunction with clinical data, effect of the present invention is done furtherly.
1 physical data
Choose my institute in January ,-2016 in January, 2015 because of menoxenia or infertile medical patient 80 example, sick Example inclusive criteria: (1) meets doctor trained in Western medicine diagnosis of polycystic ovary syndrome standard (with reference to Rotterdam's diagnosis in 2003 Standard);(2) meet differential diagnosis in tcm and belong to phlegm-damp type of suffering from a deficiency of the kidney;(3) body weight BMI >=25;(4) age is at 16-36 Between Sui;Other treatment is not carried out in (5) 3 months;(6) volunteer tested.
Being randomly divided into two groups for the treatment of groups and matched group, two groups of patient clinical datas compare zero difference.
2 Therapeutic Method
2.1 treatment groups: use treatment by Chinese herbs of the present invention: the Rhizoma Pinelliae 9 grams, Ramulus Cinnamomi 12 grams, Rhizoma Atractylodis 9 grams, Rhizoma Cyperi 15 grams, Exocarpium Citri Rubrum 15 grams, Herba Epimedii 15 grams, Radix Morindae Officinalis 10 grams, Rhizoma Chuanxiong 15 grams, Fructus Aurantii Immaturus (parched) 12 grams.Warp Early stage adds Cornu Cervi tablet 5-16 gram, Fluoritum 10-15 gram;Add Herba Leonuri 10-20 gram, Radix Bupleuri 10-20 menstrual period Gram, Radix Salviae Miltiorrhizae 10-30 gram, Herba Lycopi 10-20 gram;Add Semen Cuscutae 5-10 gram, Radix Angelicae Sinensis 10-20 gram the onset of ovulation; Add Rhizoma Dioscoreae 9-15 gram, Rhizoma Polygonati 9-15 gram, Radix Rehmanniae Preparata 9-15 gram postmenstruation;Remove in natural menstrual or Progesterone Moving back property rises and takes Chinese medicine decoction of the present invention for hemorrhage 5th day, every day potion, every day twice, colleague attention keep on a diet With add sharp movement, continuously treatment 3 months.
2.2 matched groups: with Or Metformin In Treating, each 0.5 gram, three times on the one, oral in half an hour after the meal, Treatment 3 months continuously.Diet identically controlled with test group and add sharp movement.
All treating 3 months for two groups is a course for the treatment of, normal to menstruation recovery after treatment or close to normal patient with Visit a course for the treatment of.
3 curative effect determinate standards
Total mark × 100% before 3.1 TCM syndrome curative effect rates=(total mark after total mark-treatment before treatment)/treatment
Recovery from illness: disease curative effect rate >=95% after treatment;
Effective: disease curative effect rate >=70% after treatment, < 95%
Effective: disease curative effect rate >=30% after treatment, < 70%
Invalid: disease curative effect rate < 30% after treatment
3.2 lose weight curative effect determinate standard
Short Term Clinical is fully recovered: body weight reached in normal range;Effective: more than weight loss 5KG;
Effective: more than weight loss 3kg, below 5KG;
Invalid: weight loss is less than 3kg
3.3 TCM syndrome standards of grading
Suffer from a deficiency of the kidney with reference to the menoxenia in " new Chinese medicine guideline of clinical investigations ", phlegm-damp Syndrome Scale quantifies Index is drafted, such as table 1 below
Table 1 TCM syndrome standards of grading
P < 0.05
Result shows, two groups of differences have significance, shows that tcm syndrome comparitive study, treatment group are better than matched group.
Before and after 4.2 treatments, TCM syndrome scoring is compared
The scoring of table 3 TCM syndrome is compared
Statistical analysis, self compares in two groups before and after treatment, two groups of equal P < 0.05 differences by significance, Comparing between group after treatment, P < 0.05, difference has significance.Show that treatment group and matched group all can significantly reduce TCM syndrome is marked, and treatment group is substantially better than matched group.
4.3 other results contrast
Statistical analysis, two groups to reduce effect in terms of BMI, WHR in loss of weight curative effect suitable.At sex hormone level Aspect, statistics LH, FSH, LH/FSH numeric ratio relatively, without significant difference, i.e. two groups reduction LH, FSH, LH/FSH aspect therapeutic equivalence;Two groups are reduced therapeutic equivalence on FINS, reduce treatment group on HOMA-IR too late Matched group.In terms of blood lipid level, two groups are being reduced TG, LDL-C and are raising therapeutic equivalence on HDL-C.
Detailed description of the invention
In order to make those skilled in the art be more fully understood that the present invention program, below in conjunction with specific embodiment party The present invention is described in further detail for formula.
Embodiment 1. 1 kinds treats the Chinese medicine composition of Obesity-type Polycystic Ovary Syndrome, including following component Crude drug: the Rhizoma Pinelliae 9 grams, Ramulus Cinnamomi 10 grams, Rhizoma Atractylodis 7 grams, Rhizoma Cyperi 10 grams, Exocarpium Citri Rubrum 10 grams, Herba Epimedii 10 Gram, Radix Morindae Officinalis 8 grams, Rhizoma Chuanxiong 10 grams, Fructus Aurantii Immaturus (parched) 10 grams.
Preparation method: medical material clear water soaks half an hour, after big fire is boiled, then slow fire boiling 20 minutes, take Head is decocted, and adds water decoction 15 minutes, takes two and decocts, and two decoct and even, point sooner or later takes for twice, every day potion, It serve on 3 months.
Embodiment 2. 1 kinds treats the Chinese medicine composition of Obesity-type Polycystic Ovary Syndrome, including following component Crude drug: the Rhizoma Pinelliae 12 grams, Ramulus Cinnamomi 15 grams, Rhizoma Atractylodis 10 grams, Rhizoma Cyperi 20 grams, Exocarpium Citri Rubrum 20 grams, Herba Epimedii 20 grams, Radix Morindae Officinalis 12 grams, Rhizoma Chuanxiong 20 grams, Fructus Aurantii Immaturus (parched) 15 grams.
Preparation method is with embodiment 1.
Embodiment 3. 1 kinds treats the Chinese medicine composition of Obesity-type Polycystic Ovary Syndrome, including following component Crude drug: the Rhizoma Pinelliae 9 grams, Ramulus Cinnamomi 12 grams, Rhizoma Atractylodis 9 grams, Rhizoma Cyperi 15 grams, Exocarpium Citri Rubrum 15 grams, Herba Epimedii 15 Gram, Radix Morindae Officinalis 10 grams, Rhizoma Chuanxiong 15 grams, Fructus Aurantii Immaturus (parched) 12 grams.
Preparation method is with embodiment 1.
Embodiment 4. 1 kinds treats the Chinese medicine composition of Obesity-type Polycystic Ovary Syndrome, including following component Crude drug: the Rhizoma Pinelliae 9 grams, Ramulus Cinnamomi 12 grams, Rhizoma Atractylodis 9 grams, Rhizoma Cyperi 15 grams, Exocarpium Citri Rubrum 15 grams, Herba Epimedii 15 Gram, Radix Morindae Officinalis 10 grams, Rhizoma Chuanxiong 15 grams, Fructus Aurantii Immaturus (parched) 12 grams.
Add Cornu Cervi tablet 10 grams, Fluoritum 10 grams premenstruum;Add menstrual period Herba Leonuri 15 grams, Radix Bupleuri 15 grams, Radix Salviae Miltiorrhizae 20 grams, Herba Lycopi 15 grams;Add Semen Cuscutae 8 grams, Radix Angelicae Sinensis 15 grams the onset of ovulation;Add Rhizoma Dioscoreae 12 postmenstruation Gram, Rhizoma Polygonati 12 grams, Radix Rehmanniae Preparata 12 grams.
Preparation method is with embodiment 1.
Embodiment 5. 1 kinds treats the Chinese medicine composition of Obesity-type Polycystic Ovary Syndrome, including following component Crude drug: the Rhizoma Pinelliae 10 grams, Ramulus Cinnamomi 12 grams, Rhizoma Atractylodis 8 grams, Rhizoma Cyperi 18 grams, Exocarpium Citri Rubrum 20 grams, Herba Epimedii 16 grams, Radix Morindae Officinalis 11 grams, Rhizoma Chuanxiong 16 grams, Fructus Aurantii Immaturus (parched) 12 grams.
Add Cornu Cervi tablet 8 grams, Fluoritum 10 grams premenstruum;Add menstrual period Herba Leonuri 16 grams, Radix Bupleuri 10 grams, Radix Salviae Miltiorrhizae 25 grams, Herba Lycopi 12 grams;Add Semen Cuscutae 6 grams, Radix Angelicae Sinensis 15 grams the onset of ovulation;Add Rhizoma Dioscoreae 15 postmenstruation Gram, Rhizoma Polygonati 10 grams, Radix Rehmanniae Preparata 10 grams.
Preparation method is with embodiment 1.

Claims (5)

1. treat a Chinese medicine composition for Obesity-type Polycystic Ovary Syndrome, it is characterized in that, in parts by weight, including following group Point crude drug: Rhizoma Pinelliae 9-12 part, Ramulus Cinnamomi 10-15 part, Rhizoma Atractylodis 7-10 part, Rhizoma Cyperi 10-20 part, Exocarpium Citri Rubrum 10-20 part, excessive Sheep leaves of pulse plants 10-20 part, Radix Morindae Officinalis 8-12 part, Rhizoma Chuanxiong 10-20 part, Fructus Aurantii Immaturus (parched) 10-15 part.
2. treat the Chinese medicine composition of Obesity-type Polycystic Ovary Syndrome as claimed in claim 1, it is characterized in that, in parts by weight, Crude drug including following component: the Rhizoma Pinelliae 9 parts, Ramulus Cinnamomi 12 parts, Rhizoma Atractylodis 9 parts, Rhizoma Cyperi 15 parts, Exocarpium Citri Rubrum 15 parts, Herba Epimedii 15 parts, Radix Morindae Officinalis 10 parts, Rhizoma Chuanxiong 15 parts, Fructus Aurantii Immaturus (parched) 12 parts.
3. treat the Chinese medicine composition of Obesity-type Polycystic Ovary Syndrome as claimed in claim 1 or 2, it is characterized in that, premenstruum Add Cornu Cervi tablet 5-16 part, Fluoritum 10-15 part;Add Herba Leonuri 10-20 part, Radix Bupleuri 10-20 part, Radix Salviae Miltiorrhizae 10-30 menstrual period Part, Herba Lycopi's 10-20 part;Add Semen Cuscutae 5-10 part, Radix Angelicae Sinensis 10-20 part the onset of ovulation;Add Rhizoma Dioscoreae 9-15 part, Rhizoma Polygonati postmenstruation 9-15 part, Radix Rehmanniae Preparata 9-15 part.
4. treat the Chinese medicine composition of Obesity-type Polycystic Ovary Syndrome described in claim 1 or 2 in preparation prevention and/or treatment Application in the medicine of Obesity-type Polycystic Ovary Syndrome.
5. treat the Chinese medicine composition of Obesity-type Polycystic Ovary Syndrome described in claim 3 in preparation prevention and/or treatment obesity Application in the medicine of type polycystic ovarian syndrome.
CN201610281153.7A 2016-04-29 2016-04-29 Traditional Chinese medicine composition for treating obesity type polycystic ovarian syndrome Pending CN105816617A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106334060A (en) * 2016-11-03 2017-01-18 山东中医药大学附属医院 Pharmaceutical composition for treating endomorphy type polycystic ovarian syndrome
CN108853427A (en) * 2018-08-02 2018-11-23 中山大学附属第医院 A kind of Chinese medicinal formulae for treating overweight/obesity type Stein-Leventhal syndrome
CN109045169A (en) * 2018-11-05 2018-12-21 甘肃大整健康管理股份有限公司 A kind of health care preparation having both conditioning determining female physiological periodicity and weight losing function

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104162057A (en) * 2014-08-26 2014-11-26 上海市闸北区中医医院 Traditional Chinese medicine composition for treating obese polycystic ovarian syndrome and applications thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104162057A (en) * 2014-08-26 2014-11-26 上海市闸北区中医医院 Traditional Chinese medicine composition for treating obese polycystic ovarian syndrome and applications thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106334060A (en) * 2016-11-03 2017-01-18 山东中医药大学附属医院 Pharmaceutical composition for treating endomorphy type polycystic ovarian syndrome
CN108853427A (en) * 2018-08-02 2018-11-23 中山大学附属第医院 A kind of Chinese medicinal formulae for treating overweight/obesity type Stein-Leventhal syndrome
CN109045169A (en) * 2018-11-05 2018-12-21 甘肃大整健康管理股份有限公司 A kind of health care preparation having both conditioning determining female physiological periodicity and weight losing function

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