CN101574450B - Drug for treating heart disease and preparation method thereof - Google Patents
Drug for treating heart disease and preparation method thereof Download PDFInfo
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- CN101574450B CN101574450B CN2009100671109A CN200910067110A CN101574450B CN 101574450 B CN101574450 B CN 101574450B CN 2009100671109 A CN2009100671109 A CN 2009100671109A CN 200910067110 A CN200910067110 A CN 200910067110A CN 101574450 B CN101574450 B CN 101574450B
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Abstract
The invention relates to a drug for treating heart disease and belongs to a traditional Chinese medicine and a preparation method. According to parts by weight, the raw materials made into effective ingredients include: 15-20 parts of spina date seed, 10-15 parts of valerian, 10-15 parts of vine of multiflower knotweed, 15-20 parts of salvia miltiorrhiza, 10-15 parts of adonis, 5-10 parts of safflower and 3-5 parts of liquorice. The drug has the main functions of: nourishing the heart and calming the nerves, reinforcing functional activities of the heart, invigorating blood circulation and stopping the pain, and mainly treats the following symptoms: palpitation, shortness of breath, chest distress, various arrhythmia, myocarditis, coronary artery disease, angina and cardiac failure. The drug belongs to a pure traditional Chinese medicine preparation and is characterized by unique medicine choice, ingenious composition and outstanding efficacy with less dosage. The drug yields good healing effect clinically in relieving pains from patients.
Description
Technical field
The invention belongs to a kind of Chinese medicine medicine and method for preparing, specifically be meant a kind of treatment heart disease and preparation method thereof.
Background technology
Cardiopathic clinical symptom performance; The arrhythmia that a variety of causes of doctor trained in Western medicine causes is like tachycardia, bradycardia, premature beat, heart failure, myocarditis, coronary heart disease, angina pectoris etc.; Differential diagnosis in tcm thinks it mainly is owing to YANG QI deficiency, deficiency of YIN loss, and the heart is become homeless foster and is caused.In treatment often with benefiting QI and nourishing blood, nourishing yin and warming yang, reduce phlegm that to wash drink, blood circulation promoting and blood stasis dispelling, tranquilizing by nourishing the heart be the cardiopathic principle of treatment.
At present, the cardiopathic medicine of existing treatment as: the reinforcing the heart sheet of calming the nerves, its Main Ingredients and Appearance is Radix Rehmanniae, Radix Salviae Miltiorrhizae, Cortex Albiziae, Rhizoma Acori Graminei, Semen Cuscutae, Fructus Schisandrae Chinensis etc., has nourishing blood to tranquillize the mind, the function of nourishing the liver and kidney.Cure mainly: cardiopalmus, dizzy tinnitus, insomnia forgetfulness etc.And for example: the succinum Anshen Wan, its Main Ingredients and Appearance is: the Radix Rehmanniae, Radix Angelicae Sinensis, Semen Platycladi, Semen Ziziphi Spinosae (parched), Radix Asparagi, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Scrophulariae, Radix Platycodonis, Cortex Albiziae, succinum, Os Draconis etc., its effect nourishing YIN nourishes blood, heart tonifying and tranquilizing.It is forgetful etc. to cure mainly deficiency of heart-blood, palpitation and insomnia, palpitation with a distress feeling.The said medicine weak point: it is single to cure the disease, the efficacy of a drug too a little less than, therapeutic effect is undesirable.The long patient of the old course of disease is difficult to cure, and medicining times is many in addition, inconvenient patient treatment.
Summary of the invention
The present invention provides a kind to treat cardiopathic medicine and preparation method thereof, single with curing the disease of solving that present medicine exists, the efficacy of a drug is too weak, therapeutic effect is undesirable, to the long patient of the old course of disease be difficult to cure, medicining times is many in addition, the problem of inconvenient patient treatment.
Various clinically arrhythmia, coronary heart disease, myocarditis, angina pectoris all are deficiency of heart-QI, stagnation of heart-blood and causing.Disease is seen sensation of oppression over the chest with shortness of breath, palpitation and restlessness, clinical symptoms such as precordialgia.Follow the traditional theory of the traditional Chinese medical science, Semen Ziziphi Spinosae, Rhizoma et radix valerianae, Caulis Polygoni Multiflori in the side, tranquilizing by nourishing the heart, reinforce functional activities of the heart are monarch drug altogether; Radix Salviae Miltiorrhizae, the pain relieving of Flos Carthami promoting blood circulation to remove blood stasis are ministerial drug altogether; The Herba Adonidis heart tonifying is calm, controls heart failure, is adjuvant drug; The Radix Glycyrrhizae blood-cleaning detoxifying, all medicines of blending are messenger drug; All medicines share, and play Qi-benefiting and heart-nourishing altogether, heart tonifying and tranquilizing, promoting flow of QI and blood, numbness relieving and pain relieving, the effect of giving consideration to both the incidental and fundamental.
The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and each amounts of components is for all having better curative effect in the following weight parts scope:
Semen Ziziphi Spinosae 15-20 part, Rhizoma et radix valerianae 10-15 part, Caulis Polygoni Multiflori 10-15 part, Radix Salviae Miltiorrhizae 15-20 part, Herba Adonidis 10-15 part, Flos Carthami 5-10 part, Radix Glycyrrhizae 3-5 part.
Be preferably:
17.5 parts of Semen Ziziphi Spinosaes, 12.5 parts of Rhizoma et radix valerianaes, 12.5 parts of Caulis Polygoni Multiflori, 17.5 parts of Radix Salviae Miltiorrhizaes, 12.5 parts of Herba Adonidiss, 7.5 parts on Flos Carthami, 4 parts in Radix Glycyrrhizae.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations.Preferably the method for preparing of medicine activity component of the present invention is following:
A. pulverize, Radix Glycyrrhizae porphyrize, mistake 100 mesh sieves, mixing;
B. with Semen Ziziphi Spinosae, Rhizoma et radix valerianae, Caulis Polygoni Multiflori, Radix Salviae Miltiorrhizae, Herba Adonidis, Flos Carthami, cataclasm, decoct 2～3 times, each 3～5 hours, gradation filtration, merging filtrate, be concentrated into relative density for, survey the thick paste of density 1.18-1.28 25 ℃ the time;
C. with above-mentioned Radix Glycyrrhizae medicated powder and concentrated thick paste mix homogeneously.
The active component of medicine of the present invention can add various conventional adjuvant required when preparing different dosage form; Be prepared into any peroral dosage form commonly used like disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine, like granule, pill, powder, tablet, capsule, oral liquid etc.
Behind the medicine activity component mix homogeneously of the present invention, process concentrated watered pill, put shady and cool ventilation place drying by conventional method.These article are ball-point pen type, black, the sweet little hardship of sour in the mouth.
Function of the present invention cures mainly: tranquilizing by nourishing the heart, reinforce functional activities of the heart, promoting blood circulation and stopping pain.Cure mainly: nervous, breathe hard uncomfortable in chest and various arrhythmia, myocarditis, coronary heart disease, angina pectoris, heart failure.
Medicine of the present invention belongs to pure Chinese medicinal preparation, has the medicine of choosing uniqueness, and prescription is ingenious, the characteristics of parum drug and centralize the power.Received good curative effect clinically, for the patient removes slight illness.Usage and dosage: oral, each 2 balls, every ball weigh 0.3 gram, and every ball contains crude drug amount 1.68 grams, obeys warm water delivery service 4-6 day 1 time.Medication 1 month was a course of treatment, 1～3 course of treatment of general therapeutic.
The specific embodiment
Embodiment 1 preparation tablets of the present invention
Semen Ziziphi Spinosae 150 grams, Rhizoma et radix valerianae 100 grams, Caulis Polygoni Multiflori 100 grams, Radix Salviae Miltiorrhizae 150 grams, Herba Adonidis 100 grams, Flos Carthami 50 grams, Radix Glycyrrhizae 30 grams.
Method for preparing is following:
A. pulverize, Radix Glycyrrhizae porphyrize powder is crossed 100 mesh sieves, mixing;
B. with Semen Ziziphi Spinosae, Rhizoma et radix valerianae, Caulis Polygoni Multiflori, Radix Salviae Miltiorrhizae, Herba Adonidis, Flos Carthami, cataclasm, decoct 2 times, each 3 hours, gradation filtration, merging filtrate, be concentrated into relative density for, survey the thick paste of density 1.18 25 ℃ the time;
C. with above-mentioned Radix Glycyrrhizae medicated powder and concentrated thick paste mix homogeneously;
D. add the conventional adjuvant of preparation tablet, process tablet.
The preparation of embodiment 2 pills of the present invention
Semen Ziziphi Spinosae 175 grams, Rhizoma et radix valerianae 125 grams, Caulis Polygoni Multiflori 125 grams, Radix Salviae Miltiorrhizae 175 grams, Herba Adonidis 125 grams, Flos Carthami 75 grams, Radix Glycyrrhizae 40 grams.
Method for preparing is following:
A. pulverize, Radix Glycyrrhizae porphyrize powder is crossed 100 mesh sieves, mixing;
B. with Semen Ziziphi Spinosae, Rhizoma et radix valerianae, Caulis Polygoni Multiflori, Radix Salviae Miltiorrhizae, Herba Adonidis, Flos Carthami, cataclasm, decoct 3 times, each 4 hours, gradation filtration, merging filtrate, be concentrated into relative density for, survey the thick paste of density 1.23 25 ℃ the time;
C. with above-mentioned Radix Glycyrrhizae medicated powder and concentrated thick paste mix homogeneously;
D. process concentrated watered pill 500 balls by conventional method, put shady and cool ventilation place drying, every ball weighs 0.3 gram, and every ball contains crude drug amount 1.68 grams, and these article are ball-point pen type, black, the sweet little hardship of sour in the mouth.
The preparation of embodiment 3 capsules of the present invention
Semen Ziziphi Spinosae 200 grams, Rhizoma et radix valerianae 150 grams, Caulis Polygoni Multiflori 150 grams, Radix Salviae Miltiorrhizae 200 grams, Herba Adonidis 150 grams, Flos Carthami 100 grams, Radix Glycyrrhizae 50 grams.
Method for preparing is following:
A. pulverize, Radix Glycyrrhizae porphyrize powder is crossed 100 mesh sieves, mixing;
B. with Semen Ziziphi Spinosae, Rhizoma et radix valerianae, Caulis Polygoni Multiflori, Radix Salviae Miltiorrhizae, Herba Adonidis, Flos Carthami, cataclasm, decoct 3 times, each 5 hours, gradation filtration, merging filtrate, be concentrated into relative density for, survey the thick paste of density 1.28 25 ℃ the time;
C. with above-mentioned Radix Glycyrrhizae medicated powder and concentrated thick paste mix homogeneously;
D. said medicine is dry, porphyrize, encapsulated.
Experimental example: the visual report of the clinical use of the present invention.
One, natural situation, the sick kind: heart disease
Sex: male patient's 65 examples, female patient 35 examples.
Age: 35-40 year 10 examples, 41-50 year 15 examples, 51-55 year 20 examples, 56-60 year 25 examples,
61-65 year 30 examples.
Medical history: 3-5 20 examples, 6-15 45 examples, above 35 examples of 16-20.
Patient's symptom: disease sees that cardiopalmus is uncomfortable in chest, dyspnea with shortness of breath, fatigue and asthenia, have a dizzy spell, or draws the shoulder back of the body, pharyngoxerosis, or constipation with dry stool, red tongue or purple dim, performances such as tongue is few, deep,thready and forceless pulse because of the unsuccessful precordial fullness pain of feelings will, pain.
Two, the course of treatment and administrated method:
Taking medicine 1 month is a course of treatment, takes medicine 1 time in 4-6 days, obeys 2 at every turn, after meal half an hour warm water delivery service.
Three, curative effect determinate standard:
The patient takes medicine, and electrocardiogram improves after a course of treatment, and all diseases alleviate, and effective percentage reaches 100%; Patient's clinical symptom disappearance after three courses of treatment of taking medicine, all diseases are not done behind the medicine, and cure rate reaches more than 85%.
100 routine cardiac's therapeutic outcome statistical tables
| Age | Example | Medical history | Example | Effectively | Cure |
| 35～40 | 10 | 3-5 | 20 | 20 | 19 |
| 41～50 | 15 | 6～8 | 15 | 15 | 13 |
| 51～55 | 20 | 9～10 | 20 | 20 | 16 |
| 56～60 | 25 | 10～15 | 10 | 10 | 9 |
| 61～65 | 30 | 16～20 | 35 | 35 | 28 |
| 100 | 100 | Effective percentage 100% | Cure rate 85% |
Claims (3)
1. the cardiopathic medicine of treatment is characterized in that in weight portion, processes raw materials of effective components and consists of:
Semen Ziziphi Spinosae 15-20 part, Rhizoma et radix valerianae 10-15 part, Caulis Polygoni Multiflori 10-15 part, Radix Salviae Miltiorrhizae 15-20 part, Herba Adonidis 10-15 part, Flos Carthami 5-10 part, Radix Glycyrrhizae 3-5 part.
2. the cardiopathic medicine of treatment according to claim 1 is characterized in that in weight portion, processes raw materials of effective components and consists of:
17.5 parts of Semen Ziziphi Spinosaes, 12.5 parts of Rhizoma et radix valerianaes, 12.5 parts of Caulis Polygoni Multiflori, 17.5 parts of Radix Salviae Miltiorrhizaes, 12.5 parts of Herba Adonidiss, 7.5 parts on Flos Carthami, 4 parts in Radix Glycyrrhizae.
3. according to claim 1 or claim 2 the method for preparing of the cardiopathic medicine of treatment: it is characterized in that comprising the following steps:
A. pulverize Radix Glycyrrhizae, with Radix Glycyrrhizae porphyrize, mistake 100 mesh sieves, mixing;
B. with Semen Ziziphi Spinosae, Rhizoma et radix valerianae, Caulis Polygoni Multiflori, Radix Salviae Miltiorrhizae, Herba Adonidis, Flos Carthami, cataclasm, decoct 2～3 times, each 3～5 hours, gradation filtration, merging filtrate, surveying relative density when being concentrated into 25 ℃ is the thick paste of 1.18-1.28;
C. with above-mentioned Radix Glycyrrhizae medicated powder and concentrated thick paste mix homogeneously.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100671109A CN101574450B (en) | 2009-06-15 | 2009-06-15 | Drug for treating heart disease and preparation method thereof |
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| CN2009100671109A CN101574450B (en) | 2009-06-15 | 2009-06-15 | Drug for treating heart disease and preparation method thereof |
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| CN101574450A CN101574450A (en) | 2009-11-11 |
| CN101574450B true CN101574450B (en) | 2012-05-02 |
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| CN103933148B (en) * | 2014-03-19 | 2015-08-19 | 青岛市市立医院 | The ARR pharmaceutical composition of a kind of control and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129616A (en) * | 2007-08-27 | 2008-02-27 | 尹克华 | Traditional Chinese medicine for treating rheumatic heart disease |
| CN101422562A (en) * | 2007-10-29 | 2009-05-06 | 辽宁中医药大学附属医院 | Medicine for treating premature beat and atrial fibrillation |
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2009
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129616A (en) * | 2007-08-27 | 2008-02-27 | 尹克华 | Traditional Chinese medicine for treating rheumatic heart disease |
| CN101422562A (en) * | 2007-10-29 | 2009-05-06 | 辽宁中医药大学附属医院 | Medicine for treating premature beat and atrial fibrillation |
Non-Patent Citations (2)
| Title |
|---|
| 卢富华.黄春林治疗心律失常的经验.《湖北中医杂志》.2005,第27卷(第4期),23-24. * |
| 郑梅生.中医药治疗冠心病心律失常的临床研究述评.《中国中医基础医学杂志》.1999,第5卷(第7期),3-7. * |
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