CN103933148B - The ARR pharmaceutical composition of a kind of control and application thereof - Google Patents
The ARR pharmaceutical composition of a kind of control and application thereof Download PDFInfo
- Publication number
- CN103933148B CN103933148B CN201410101567.8A CN201410101567A CN103933148B CN 103933148 B CN103933148 B CN 103933148B CN 201410101567 A CN201410101567 A CN 201410101567A CN 103933148 B CN103933148 B CN 103933148B
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- prepared
- chinese medicine
- medicine extract
- treat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses the ARR pharmaceutical composition of a kind of control and application thereof, said composition is prepared from by Chinese medicine extract and adjuvant, and wherein said Chinese medicine extract is prepared from through decoction and alcohol sedimentation technique by the traditional Chinese medicinal material raw materials of following weight portion: Herba Pyrolae 21-30 part, Semen Ziziphi Spinosae 36-50 part, Flos Carthami 7-14 part, Radix Sophorae Tonkinensis 10-18 part, Fructus Arctii 21-30 part.The pharmaceutical composition that the present invention relates to prevents and treats ARR determined curative effect, and the cost of medication is simultaneously few, and safety is higher.
Description
Technical field
The invention belongs to technical field of Chinese medicine, prevent and treat ARR pharmaceutical composition in particular to one, particularly relate to a kind of pharmaceutical composition and the application thereof that prevent and treat ventricular arrhythmia.
Background technology
Arrhythmia is because the exciting exception of sinuatrial node or excitement result from beyond sinuatrial node, exciting conduction slowly, retardance or through abnormal passage conduction, namely the origin of cardiomotility and (or) conductive impairment cause frequency and (or) the allorhythmia of heartbeat.Ventricular arrhythmia refers to the cardiac arrhythmia originating from ventricle, is common arrhythmia, comprises ventricular premature contraction (room early), ventricular tachycardia (room speed), ventricular fibrillation (quivering in room) etc.But anti-arrhythmic conventional clinically is at present based on Western medicine, and can bring out conduction block and heart failure at dosage during improper or long-term prescription, incidence rate is 3% ~ 13%.
Summary of the invention
The object of the present invention is to provide the ARR pharmaceutical composition of a kind of control and application thereof.This pharmaceutical composition, as the cardiopathic secret prescription handed down in the family from generation to generation for the treatment of, finds that after animal experiment study it is to prevent and treat the curative effect in arrhythmia also very good, is especially applicable to the patient medication treatment of ventricular arrhythmia.
The object of the present invention is achieved like this:
The ARR pharmaceutical composition of a kind of control, be prepared from by Chinese medicine extract and adjuvant, wherein said Chinese medicine extract is prepared from through decoction and alcohol sedimentation technique by the traditional Chinese medicinal material raw materials of following weight portion: Herba Pyrolae 21-30 part, Semen Ziziphi Spinosae 36-50 part, Flos Carthami 7-14 part, Radix Sophorae Tonkinensis 10-18 part, Fructus Arctii 21-30 part.
Preferably, the ARR pharmaceutical composition of one control as above, wherein said Chinese medicine extract is prepared from through decoction and alcohol sedimentation technique by the traditional Chinese medicinal material raw materials of following weight portion: Herba Pyrolae 24-26 part, Semen Ziziphi Spinosae 40-45 part, Flos Carthami 9-11 part, Radix Sophorae Tonkinensis 12-15 part, Fructus Arctii 24-26 part.
Further preferably, the ARR pharmaceutical composition of control described above, wherein said Chinese medicine extract is prepared from through decoction and alcohol sedimentation technique by the traditional Chinese medicinal material raw materials of following weight portion: Herba Pyrolae 25 parts, Semen Ziziphi Spinosae 42 parts, 10 parts, Flos Carthami, Radix Sophorae Tonkinensis 13 parts, Fructus Arctii 25 parts.
Again further preferably, the ARR pharmaceutical composition of control as mentioned above, wherein said pharmaceutical composition is solid orally ingestible; Described solid orally ingestible comprises tablet, capsule and granule.
The preparation method of compound granule of the present invention comprises the steps: to take by recipe quantity the Herba Pyrolae 21-30 part cleaned up, Semen Ziziphi Spinosae 36-50 part, Flos Carthami 7-14 part, Radix Sophorae Tonkinensis 10-18 part and Fructus Arctii 21-30 part, merge, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is the extractum of 1.15, adding 95% (v/v) ethanol makes alcohol content reach 75% (v/v), stir, leave standstill 24 hours, filter, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverize 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin 1:2 ~ 4 takes clear paste powder, dextrin, and measure appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is the ethanol water of 55%, drops in trough type mixing machine by clear paste powder and dextrin, stirs 20 minutes, slowly add 55% ethanol while stirring, to making soft material, granulate with 12 order stainless steel sifts, 65 ~ 75 DEG C of dryings 2 hours, take out, cool and obtain described granule.
Found by a large amount of animal experiment study, pharmaceutical composition of the present invention prevents and treats ARR effect highly significant.Therefore, second object of the present invention is to provide a kind of pharmaceutical applications, the application of namely above-mentioned pharmaceutical composition in the ARR medicine of preparation control; Especially the application of preferably above-mentioned pharmaceutical composition in the medicine of preparation control ventricular arrhythmia.
Compared with prior art, the pharmaceutical composition that the present invention relates to is prepared from by the Chinese crude drug comparatively commonly used, after the dosage strengthening Semen Ziziphi Spinosae and Fructus Arctii, gomi herbs is collaborative plays antiarrhythmic curative effect, obviously can reduce the incidence rate quivered in ventricular premature contraction and room, postpone arrhythmia time of origin and also shorten the arrhythmia persistent period.In addition, because medicine of the present invention adopts comparatively conventional Chinese crude drug to be prepared from, toxicity is low, and patient medication is safer, and the cost of medication is simultaneously few.
Detailed description of the invention
It should be noted that, the traditional Chinese medicinal material raw materials source that various embodiments of the present invention adopt is as follows: Herba Pyrolae selects the dry herb into Pyrolaceae plant Herba pyrolae japonicae Pyrola calliantha H.Andres or ovum leaf Herba pyrolae japonicae Pyrola decorata H.Andres.Semen Ziziphi Spinosae selects Rhamnaceae plant Ziziphi Spinosae Ziziphus jujuba Mill.var.spinosa(Bunge) dry mature seed of Hu ex H.F.Chou.Flos Carthami selects the dried floral of feverfew Flos Carthami Carthamustinctorius L..Radix Sophorae Tonkinensis selects the dry root and rhizome of leguminous plant Sophora tonkinensis Gagnep. Sophora tonkinensis Gapnep..Fructus Arctii selects the dry mature fruit of feverfew Fructus Arctii Arctium lappa L..
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
The preparation of embodiment 1 Chinese medicine granules
Take the Herba Pyrolae 0.25kg cleaned up, Semen Ziziphi Spinosae 0.42kg, Flos Carthami 0.10kg, Radix Sophorae Tonkinensis 0.13kg and Fructus Arctii 0.25kg, merge, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is the extractum of 1.15, adding 95% (v/v) ethanol makes alcohol content reach 75% (v/v), stir, leave standstill 24 hours, filter, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverize 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin=1:3 takes clear paste powder, dextrin, and measure appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is the ethanol water of 55%, drops in trough type mixing machine by clear paste powder and dextrin, stir 20 minutes, slowly adding 55% ethanol while stirring, to making soft material, granulating with 12 order stainless steel sifts, 65 ~ 75 DEG C of dryings 2 hours, take out, cool and obtain described granule, by every bag of 10g packaging.
The preparation of embodiment 2 Chinese medicine granules
Take the Herba Pyrolae 0.22kg cleaned up, Semen Ziziphi Spinosae 0.45kg, Flos Carthami 0.11kg, Radix Sophorae Tonkinensis 0.10kg and Fructus Arctii 0.30kg, merge, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is the extractum of 1.15, adding 95% (v/v) ethanol makes alcohol content reach 75% (v/v), stir, leave standstill 24 hours, filter, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverize 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin=1:3 takes clear paste powder, dextrin, and measure appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is the ethanol water of 55%, drops in trough type mixing machine by clear paste powder and dextrin, stir 20 minutes, slowly adding 55% ethanol while stirring, to making soft material, granulating with 12 order stainless steel sifts, 65 ~ 75 DEG C of dryings 2 hours, take out, cool and obtain described granule, by every bag of 10g packaging.
The preparation of embodiment 3 Chinese medicine granules
Take the Herba Pyrolae 0.30kg cleaned up, Semen Ziziphi Spinosae 0.50kg, Flos Carthami 0.07kg, Radix Sophorae Tonkinensis 0.15kg and Fructus Arctii 0.26kg, merge, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, when being evaporated to 65 DEG C at 60-70 DEG C, relative density is the extractum of 1.15, adding 95% (v/v) ethanol makes alcohol content reach 75% (v/v), stir, leave standstill 24 hours, filter, filtrate is at 0.07MPa, under 65 DEG C of conditions, concentrating under reduced pressure one-tenth is 1.25 to relative density when 65 DEG C, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverize 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin=1:3 takes clear paste powder, dextrin, and measure appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is the ethanol water of 55%, drops in trough type mixing machine by clear paste powder and dextrin, stir 20 minutes, slowly adding 55% ethanol while stirring, to making soft material, granulating with 12 order stainless steel sifts, 65 ~ 75 DEG C of dryings 2 hours, take out, cool and obtain described granule, by every bag of 10g packaging.
Embodiment 4 Chinese medicine is studied the controlling experiment of arrhythmia rat model
Male SD rat 24, body weight 180-220g, is divided into model control group and treatment group at random, often organizes 12.Two groups of rats give corresponding tested material as follows:
Model control group: give to wait capacity purified water gavage, every day 1 time, continuous 1 week gavage.
Treatment group: give clear paste powder prepared by embodiment 1, by the dosage gavage of 80mg/kg body weight, every day 1 time, continuous 1 week gastric infusion.
30min after last medicine, with 10% chloral hydrate anesthesia (3.5mL/kg), connects electrocardiograph, record normal ECG, sublingual vein injection barium chloride 4mg/kg, arrhythmia time of occurrence, persistent period and arrhythmia generation number after observation administration.
Result of the test shows, and intravenous injection calcium chloride can bring out ventricular premature contraction (VP) or quiver (VF) in room, and incidence rate is 100%; Treatment group compares the incidence rate that obviously can reduce VP, VF with model group, postpone arrhythmia time of origin and shorten the arrhythmia persistent period, this imply that Chinese medicine extract of the present invention has the arrhythogenic effect of anti-barium chloride, the results are shown in Table 1.
After table 1 liang group rat modeling, ARR time of origin and persistent period compare
Compare with model control group, ▼ P < 0.01.
Claims (6)
1. prevent and treat the pharmaceutical composition of ventricular arrhythmia for one kind, be prepared from by Chinese medicine extract and adjuvant, it is characterized in that described Chinese medicine extract is prepared from through decoction and alcohol sedimentation technique by the traditional Chinese medicinal material raw materials of following weight portion: Herba Pyrolae 21-30 part, Semen Ziziphi Spinosae 36-50 part, Flos Carthami 7-14 part, Radix Sophorae Tonkinensis 10-18 part, Fructus Arctii 21-30 part.
2. prevent and treat the pharmaceutical composition of ventricular arrhythmia according to claim 1, it is characterized in that described Chinese medicine extract is prepared from through decoction and alcohol sedimentation technique by the traditional Chinese medicinal material raw materials of following weight portion: Herba Pyrolae 24-26 part, Semen Ziziphi Spinosae 40-45 part, Flos Carthami 9-11 part, Radix Sophorae Tonkinensis 12-15 part, Fructus Arctii 24-26 part.
3. prevent and treat the pharmaceutical composition of ventricular arrhythmia according to claim 2, it is characterized in that described Chinese medicine extract is prepared from through decoction and alcohol sedimentation technique by the traditional Chinese medicinal material raw materials of following weight portion: Herba Pyrolae 25 parts, Semen Ziziphi Spinosae 42 parts, 10 parts, Flos Carthami, Radix Sophorae Tonkinensis 13 parts, Fructus Arctii 25 parts.
4. according to any one of claim 1-3, prevent and treat the pharmaceutical composition of ventricular arrhythmia, it is characterized in that: described pharmaceutical composition is solid orally ingestible.
5. prevent and treat the pharmaceutical composition of ventricular arrhythmia according to claim 4, it is characterized in that: described solid orally ingestible comprises tablet, capsule and granule.
6. the application of the pharmaceutical composition described in any one of claim 1-3 in the medicine of preparation control ventricular arrhythmia.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410101567.8A CN103933148B (en) | 2014-03-19 | 2014-03-19 | The ARR pharmaceutical composition of a kind of control and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410101567.8A CN103933148B (en) | 2014-03-19 | 2014-03-19 | The ARR pharmaceutical composition of a kind of control and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103933148A CN103933148A (en) | 2014-07-23 |
| CN103933148B true CN103933148B (en) | 2015-08-19 |
Family
ID=51181205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410101567.8A Expired - Fee Related CN103933148B (en) | 2014-03-19 | 2014-03-19 | The ARR pharmaceutical composition of a kind of control and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103933148B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857273A (en) * | 2015-05-07 | 2015-08-26 | 青岛市市立医院 | Medicine for curing chronic heart rate disorder of elderly people |
| CN105106438A (en) * | 2015-09-23 | 2015-12-02 | 青岛友诚高新技术有限公司 | Traditional Chinese medicine composition for treating arrhythmia and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101574450B (en) * | 2009-06-15 | 2012-05-02 | 李成国 | Medicine for treating heart disease and preparation method thereof |
-
2014
- 2014-03-19 CN CN201410101567.8A patent/CN103933148B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN103933148A (en) | 2014-07-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102225138B (en) | Traditional Chinese medicine composition for treating fracture and preparation method and application thereof | |
| CN103933148B (en) | The ARR pharmaceutical composition of a kind of control and application thereof | |
| CN101088546A (en) | Heart-benefiting Yixinshu micropill and its prepn process | |
| KR102342819B1 (en) | Formulation of a micro drop pill and the preparation method thereof | |
| CN104001004A (en) | Traditional Chinese medicine composition for curing fractures and osteoporosis and preparation method and application thereof | |
| CN103690832B (en) | A kind of Chinese medicine composition for the treatment of viral myocarditis | |
| CN107007614A (en) | The medical usage of cycloastragenol | |
| CN111450143B (en) | Application of ficus microcarpa leaf extract in preparation of medicine for preventing and/or treating liver pathological changes | |
| CN105998244B (en) | A kind of Chinese medicine preparation for chronic heart failure | |
| CN106109625B (en) | A kind of preparation method of Chinese medicine preparation for heart failure treatment | |
| CN106943390B (en) | Application of the Strychnos nux-vomica aglycon in preparation prevention or treatment antiarrhythmic medicament | |
| CN105106663A (en) | Pharmaceutical preparation for treating arrhythmia | |
| CN104189770A (en) | Pharmaceutical composition for treating tuberculous pleuritis and preparation method thereof | |
| JPS61194031A (en) | Agent for promoting carcinostatic activity | |
| CN101579440A (en) | Traditional Chinese medicine preparation used for thrombocytopenia and leukopenia | |
| CN107625875A (en) | A kind of preparation method and purposes of Allium wallichii extract | |
| CN107890479B (en) | A Chinese medicinal capsule for treating coronary heart disease, and its preparation method | |
| CN102000168B (en) | Medicament for reducing blood sugar | |
| CN118267418A (en) | Plant composition for reducing uric acid, preparation method and gel candy | |
| CN104042772B (en) | A kind of Chinese medicine composition and preparation method for strengthening immunologic function | |
| CN105250847A (en) | Medicinal composition for treating asthma and application thereof | |
| CN105381407A (en) | Qi regulating and heart soothing tablet and preparation method thereof | |
| CN112316125A (en) | Traditional Chinese medicine composition based on hirudin and preparation method of micropills thereof | |
| CN105395514A (en) | Zhonghua ganling capsule and preparation method thereof | |
| CN111419948A (en) | Anti-fatigue composition and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150819 Termination date: 20160319 |