A kind of medicine for the treatment of coronary heart disease
Technical field
The present invention relates to a kind of medicine for the treatment of coronary heart disease, belong to technical field of Chinese medicines.
Background technology
Coronary heart disease is the heart disease of a kind of myocardial ischemia-anoxemia (angina pectoris) of being caused by coronary artery organic (atherosclerosis or dynamic property vasospasm) stenosis or occlusion or myocardial necrosis (myocardial infarction), also known as ischemic heart desease.Along with the raising of people's living standard, the change of living habit, and the progress faster of aging society, the sickness rate of coronary heart disease increases day by day, affect coronary heart disease occur, development risk factor increasing, seriously jeopardize the health of the mankind.Statistics show, the prevalence of coronary heart disease be generally male higher than women, China in 2011 dies from coronary heart disease number and reaches 3,000,000, and patients with coronary heart disease sum reaches 2.7 hundred million, and wherein the patient of 70 years old accounts for more than 60%, coronary heart disease to the lethality of old people up to 80%.In recent years along with the change of people life style and work rhythm, the sickness rate of coronary heart disease presents the trend of rejuvenation gradually, and in 30-35 year crowd, the sickness rate of patients with coronary heart disease accounts for 5% of whole incidence of coronary heart disease number.Thus the Therapy study of coronary heart disease is seemed particularly urgent.
For the treatment key agents treatment of coronary heart disease and operative treatment two kinds of methods in current doctor trained in Western medicine, but Western medicine side effect is large, and cures the symptoms, not the disease; And operative therapy has a big risk, costly, patient's misery of bearing is large.Coronary heart disease belongs to the category of " thoracic obstruction ", " pained " in the traditional Chinese medical science, uses Coronary Heart Diseases Treated with TCM can not only improve the symptom of patient and can improve the pathology damage of patient to a great extent, shows the advantage that it is unique in coronary heart disease treatment.Market today exists the Chinese medicine for the treatment of coronary heart disease miscellaneous, but their therapeutic effect is general not high, the course for the treatment of is longer, cures the defects such as rear easily recurrence.
Summary of the invention
For problems of the prior art, the invention provides a kind of medicine for the treatment of coronary heart disease.This medicine is formed by pure traditional Chinese medicine, and scientific formulation is reasonable, and have curative effect high, instant effect, do not recur more, cost is low, the feature that safety has no side effect.
The present invention is by the following technical solutions:
A kind of medicine for the treatment of coronary heart disease, it is characterized in that, it is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 10-20 part, Rhizoma Chuanxiong 5-15 part, Fructus Perillae 6-10 part, Radix Paeoniae Rubra 20-30 part, Flos Carthami 10-20 part, Rhizoma Corydalis 15-25 part, Lignum Santali Albi 10-20 part, Radix Curcumae 4-8 part, Sanguis Draxonis 2-6 part, Rhizoma Kaempferiae 10-20 part, Herba Asari 6-12 part, Semen Persicae 8-16 part, Pollen Typhae 10-20 part, Radix Cyathulae 15-25 part, Rhizoma Curcumae 10-16 part, Fructus Fici 20-30 part, Semen Sinapis Albae 4-8 part, Radix Scrophulariae 8-12 part, Radix Arnebiae (Radix Lithospermi) 3-8 part, Rhizoma Cimicifugae 10-15 part, Semen Cuscutae 15-25 part, Rhizoma Polygonati Odorati 10-20 part, Herba Cistanches 20-30 part.
Preferably, the medicine of above-mentioned treatment coronary heart disease is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 15 parts, Rhizoma Chuanxiong 10 parts, Fructus Perillae 8 parts, Radix Paeoniae Rubra 25 parts, 15 parts, Flos Carthami, Rhizoma Corydalis 20 parts, 15 parts, Lignum Santali Albi, Radix Curcumae 6 parts, Sanguis Draxonis 5 parts, Rhizoma Kaempferiae 15 parts, Herba Asari 8 parts, 12 parts, Semen Persicae, Pollen Typhae 15 parts, Radix Cyathulae 20 parts, Rhizoma Curcumae 14 parts, Fructus Fici 25 parts, Semen Sinapis Albae 6 parts, Radix Scrophulariae 10 parts, Radix Arnebiae (Radix Lithospermi) 6 parts, Rhizoma Cimicifugae 12 parts, Semen Cuscutae 20 parts, Rhizoma Polygonati Odorati 15 parts, Herba Cistanches 25 parts.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation, is prepared into any one in tablet, pill, capsule, granule, oral liquid or decoction.
Preferred dosage form of the present invention is capsule.Above medical material is joined by measuring, and pulverized by described medicine as powder crosses 100 mesh sieves afterwards, mixing sterilization incapsulates, and each capsule gets product by 0.4 gram of dress.
Usage of the present invention and consumption: oral, one day 3 times, each 3, within 1 hour after meal, taking, 10 days was 1 course for the treatment of, and general 1 course for the treatment of can take effect, and 3-4 the course for the treatment of can cure, and patient with severe symptoms needs 5-6 the course for the treatment of.
Medicine pharmacological action of the present invention is as follows:
Radix Angelicae Sinensis: sweet, pungent, warm; Return liver, the heart, spleen channel; There is benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation, anticancer, anti-ageing anti-old, immune effect.Rhizoma Chuanxiong: pungent, temperature; Enter liver, gallbladder meridian; Have activating QI to alleviate the depression, method wind-dryness is wet, effect of promoting blood circulation and stopping pain.Fructus Perillae: pungent, temperature; Return lung meridian; There is sending down the abnormal ascending QI expectorant, relieving cough and asthma, effect of intestine moistening.Radix Paeoniae Rubra: bitter, is slightly cold; Return Liver Channel; There is clearing away heat and cooling blood, effect of blood circulation promoting and blood stasis dispelling.Flos Carthami: pungent, temperature; GUIXIN, Liver Channel; There is promoting blood circulation to restore menstrual flow, effect of eliminating stasis to stop pain.Rhizoma Corydalis: pungent, bitter, temperature; Return liver, spleen channel; Have and invigorate blood circulation, circulation of qi promoting, effect of pain relieving.Lignum Santali Albi: pungent, temperature; Return spleen, stomach, the heart, lung meridian; There is circulation of qi promoting warming middle-JIAO, effect of appetizing pain relieving.Radix Curcumae: pungent, bitter, cold; Return liver, the heart, lung meridian; Have promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clear away heart-fire removing heat from blood, effect of promoting the function of the gallbladder to alleviate jaundice.Sanguis Draxonis: sweet, salty is flat; GUIXIN, Liver Channel; There is analgesic therapy of invigorating blood circulation, removing stasis to stop bleeding, effect of expelling pus and promoting granulation.Rhizoma Kaempferiae: pungent, temperature; Return spleen, stomach warp; There is warming middle-JIAO for eliminating dampness, effect of promoting the circulation of QI to relieve pain.Herba Asari: pungent, temperature; GUIXIN, lung, kidney channel; There is the cold expelling that induces sweat, wind-expelling pain-stopping, sensible, effect of warming the lung to resolve fluid-retention.Semen Persicae: bitter, sweet, flat; GUIXIN, liver, large intestine channel; There is blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, effect of relieving cough and asthma.Pollen Typhae: sweet, flat; Return liver, pericardium channel; There is hemostasis, blood stasis dispelling, treating stranguria effect.Radix Cyathulae: sweet, micro-hardship, flat; Return liver, kidney channel; There is eliminating blood stasis and inducing menstruation, easing joint movement, effect of inducing diuresis for treating stranguria syndrome.Rhizoma Curcumae: pungent, bitter, temperature; Return liver, spleen channel; There is removing blood stasis circulation of qi promoting, effect of removing food stagnancy pain relieving.Fructus Fici: flat, sweet; Return spleen channel; There is invigorating the spleen and benefiting QI, subduing swelling and detoxicating, nourish effect of intestine moistening.Semen Sinapis Albae: odorless, pungent, peppery; Enter meridian of Hand-TAI YIN; There is warming the lung eliminating phlegm promoting the circulation of QI, effect of resolving mass and removing the obstruction of the collateral pain relieving.Radix Scrophulariae: sweet, bitter, salty, is slightly cold; Return spleen, stomach, kidney channel; Clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, effect of detoxicating and resolving stagnation of pathogens.Radix Arnebiae (Radix Lithospermi): sweet, salty, cold; GUIXIN, Liver Channel; There is removing heat from blood and promoting blood circulation, effect of removing toxic substances rash.Rhizoma Cimicifugae: pungent, sweet, is slightly cold; Return lung, spleen, large intestine, stomach warp; Deliver rash, heat-clearing and toxic substances removing, effect of ascending up spleen-Qi and Yang.Semen Cuscutae: Xin Gan is flat; Enter liver, kidney channel; Nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, effect of improving eyesight antidiarrheal.Rhizoma Polygonati Odorati: sweet, flat; Enter lung, stomach warp; There is nourishing YIN to relieve dryness, effect of promoting the production of body fluid to quench thirst.Herba Cistanches: sweet, salty, warm in nature; Return kidney, large intestine channel; There is kidney-replenishing, benefiting essence-blood, the effect in intestine moistening road.
The invention has the beneficial effects as follows: pharmaceutical formulation of the present invention is scientific and reasonable, its drug effect has synergism, has effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, invigorating the spleen and replenishing QI, warming the kidney to invigorate YANG, effectively can regulate cardiac function.Prove through clinical application for many years, medicine of the present invention is evident in efficacy to various coronary heart disease, and the property of medicine is gentle, and rapidly effective, cure rate is high, does not recur, safe without toxic side effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.
Embodiment 1
Treat a medicine for coronary heart disease, it is made up of the crude drug of following weight: Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 5g, Fructus Perillae 6g, Radix Paeoniae Rubra 20g, Flos Carthami 10g, Rhizoma Corydalis 15g, Lignum Santali Albi 10g, Radix Curcumae 4g, Sanguis Draxonis 2g, Rhizoma Kaempferiae 10g, Herba Asari 6g, Semen Persicae 8g, Pollen Typhae 10g, Radix Cyathulae 15g, Rhizoma Curcumae 10g, Fructus Fici 20g, Semen Sinapis Albae 4g, Radix Scrophulariae 8g, Radix Arnebiae (Radix Lithospermi) 3g, Rhizoma Cimicifugae 10g, Semen Cuscutae 15g, Rhizoma Polygonati Odorati 10g, Herba Cistanches 20g.
Joined by measuring by above-mentioned medical material, pulverized by described medicine as powder crosses 100 mesh sieves afterwards, mixing sterilization incapsulates, and each capsule gets product by 0.4 gram of dress.
Embodiment 2
Treat a medicine for coronary heart disease, it is made up of the crude drug of following weight: Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 10g, Fructus Perillae 8g, Radix Paeoniae Rubra 25g, Flos Carthami 15g, Rhizoma Corydalis 20g, Lignum Santali Albi 15g, Radix Curcumae 6g, Sanguis Draxonis 5g, Rhizoma Kaempferiae 15g, Herba Asari 8g, Semen Persicae 12g, Pollen Typhae 15g, Radix Cyathulae 20g, Rhizoma Curcumae 14g, Fructus Fici 25g, Semen Sinapis Albae 6g, Radix Scrophulariae 10g, Radix Arnebiae (Radix Lithospermi) 6g, Rhizoma Cimicifugae 12g, Semen Cuscutae 20g, Rhizoma Polygonati Odorati 15g, Herba Cistanches 25g.
Joined by measuring by above-mentioned medical material, pulverized by described medicine as powder crosses 100 mesh sieves afterwards, mixing sterilization incapsulates, and each capsule gets product by 0.4 gram of dress.
Embodiment 3
Treat a medicine for coronary heart disease, it is made up of the crude drug of following weight: Radix Angelicae Sinensis 20g, Rhizoma Chuanxiong 15g, Fructus Perillae 10g, Radix Paeoniae Rubra 30g, Flos Carthami 20g, Rhizoma Corydalis 25g, Lignum Santali Albi 20g, Radix Curcumae 8g, Sanguis Draxonis 6g, Rhizoma Kaempferiae 20g, Herba Asari 12g, Semen Persicae 16g, Pollen Typhae 20g, Radix Cyathulae 25g, Rhizoma Curcumae 16g, Fructus Fici 30g, Semen Sinapis Albae 8g, Radix Scrophulariae 12g, Radix Arnebiae (Radix Lithospermi) 8g, Rhizoma Cimicifugae 15g, Semen Cuscutae 25g, Rhizoma Polygonati Odorati 20g, Herba Cistanches 30g.
Joined by measuring by above-mentioned medical material, pulverized by described medicine as powder crosses 100 mesh sieves afterwards, mixing sterilization incapsulates, and each capsule gets product by 0.4 gram of dress.
Embodiment 4
Treat a medicine for coronary heart disease, it is made up of the crude drug of following weight: Radix Angelicae Sinensis 14g, Rhizoma Chuanxiong 8g, Fructus Perillae 9g, Radix Paeoniae Rubra 28g, Flos Carthami 12g, Rhizoma Corydalis 22g, Lignum Santali Albi 16g, Radix Curcumae 5g, Sanguis Draxonis 5g, Rhizoma Kaempferiae 15g, Herba Asari 10g, Semen Persicae 14g, Pollen Typhae 18g, Radix Cyathulae 18g, Rhizoma Curcumae 14g, Fructus Fici 28g, Semen Sinapis Albae 7g, Radix Scrophulariae 12g, Radix Arnebiae (Radix Lithospermi) 6g, Rhizoma Cimicifugae 14g, Semen Cuscutae 18g, Rhizoma Polygonati Odorati 16g, Herba Cistanches 22g.
Joined by measuring by above-mentioned medical material, pulverized by described medicine as powder crosses 100 mesh sieves afterwards, mixing sterilization incapsulates, and each capsule gets product by 0.4 gram of dress.
Clinical practice example
1. clinical data: patients with coronary heart disease 660 example is accepted in random selecting outpatient service for medical treatment, be divided into two groups of i.e. treatment group and matched groups, clinical data there was no significant difference between two groups, two groups of ages, sex, the course of disease, complication etc. are through statistical procedures, difference there are no significant meaning (P>0. 05), has comparability.
2. diagnostic criteria: according to clinical medical history or electrocardiogram, open in-heart operation under pulsating, the sports load electrocardiogram of angina pectoris, myocardial infarction, Nuclear Cardiac Imaging and coronarography can be made a definite diagnosis.
3. Therapeutic Method: the medicine that treatment group uses the embodiment of the present invention 2 obtained, oral, one day 3 times, each 3, within 1 hour after meal, taking, 10 days was 1 course for the treatment of, and general 1 course for the treatment of can take effect, and 3-4 the course for the treatment of can cure, and patient with severe symptoms needs 5-6 the course for the treatment of.Matched group uses conventional western medicine treatment, as Drug therapys such as sorbide nitrate, beta-blocker, aspirin, verapamil, simvastatins, treats observe the curative effect after 60 days continuously.
4. curative effect determinate standard:
Cure: normal ECG, clinical symptoms all disappears, and follows up a case by regular visits to more than 1 year without recurrence;
Take a turn for the better: electrocardiogram is clearly better, clinical symptoms obviously alleviates or disappears more than half;
Invalid: electrocardiogram is without significant change, and clinical symptoms is without improvement.
5. therapeutic outcome: in table 1.
Table 1 clinical treatment outcome
Group |
Case load |
Cure n |
Improvement n |
Invalid n |
Total effective rate % |
Treatment group |
330 |
286 |
42 |
2 |
99.4% |
Matched group |
330 |
195 |
55 |
80 |
75.8% |
As can be seen from the above results, the treatment of medicine of the present invention to coronary heart disease has curative effect more better than general Western medicine, and its treatment total effective rate, up to 99.4%, is that one treats coronary heart disease good medicine, brings glad tidings to vast middle-old aged coronary heart disease patient.
Model case
Case 1: money, man, 60 years old, uncomfortable in chest, profuse sweating, Nausea and vomiting and time and with squeezing property pain after breastbone, there is angina pectoris once in a while, be diagnosed as coronary heart disease.After using 1 course for the treatment of of medicine of the embodiment of the present invention 2, clinical symptoms obviously alleviates, and angina pectoris attacks is elongated gradually for interval time, and after 2 courses for the treatment of of rear continuation after treatment, clinical symptoms all disappears, and follows up a case by regular visits to and does not recur for 2 years.
Case 2: what so-and-so, man, 48 years old, chest pain was had a surplus for 3 years repeatedly, can dyspnea when increasing the weight of, and cardiopalmus, companioned with headache is felt sick, and tentative diagnosis is coronary heart disease.After using 3 courses for the treatment of of medicine of the embodiment of the present invention 3, patient clinical symptom all disappears, and follows up a case by regular visits to and does not recur for 1 year.
Case 3: Cai so-and-so, female, 58 years old, paroxysmal chest pain, more than 2 years, was shown effect more than 10 time every day, and with nausea and vomiting, nervous symptom uncomfortable in chest, clinical diagnosis is coronary heart disease.After using 4 courses for the treatment of of medicine of the embodiment of the present invention 1, clinical symptoms all disappears, and follows up a case by regular visits to a year and a half not recur.
Case 4: Guo so-and-so, man, 72 years old, suffer from coronary heart disease to have a surplus for 6 years, often uncomfortable in chest, breathe hard, dizziness, feel sick and with time and angina pectoris sense, angina pectoris attacks was frequent afterwards, constriction uncomfortable in chest is more and more serious, then here treatment, after using 2 courses for the treatment of of medicine of the embodiment of the present invention 4, clinical symptom disappearance is more than half, continue to strengthen patient's recovery from illness after 2 courses for the treatment of of treatment, follow up a case by regular visits to and do not recur for 3 years.