CN102552520A - Blood circulation-promoting and pain-stopping medicament for treating chest stuffiness and pains and preparation process and application thereof - Google Patents
Blood circulation-promoting and pain-stopping medicament for treating chest stuffiness and pains and preparation process and application thereof Download PDFInfo
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Abstract
The invention relates to a blood circulation-promoting and pain-stopping medicament for treating chest stuffiness and pains. The medicament consists of the following bulk pharmaceuticals in parts by weight: 12-18 parts of Chinese angelica, 12-18 parts of rehmannia root, 6-10 parts of officinal magnolia bark, 6-10 parts of cassia twig, 8-12 parts of szechuan lovage rhizome, 12-18 parts of tree peony root-bark, 8-12 parts of sargentg loryvine stem, 8-12 parts of corydalis tuber, 8-12 parts of safflower, 6-10 parts of immature bitter orange, 8-12 parts of red paeony root, 8-12 parts of fortune's drynaria rhizome and 3-5 parts of borneol. A preparation process of the medicament comprises the following steps of: smashing 3-5 parts by weight of borneol into fine powder of 120-150 meshes; smashing other medicinal materials except borneol into fine powder of 20-40 meshes, and performing ethanol extraction to obtain ethanol extract fine powder; and uniformly mixing the products. After the medicinal materials are used together, the effects of promoting blood circulation, removing blood stasis, promoting qi circulation and relieving pain are achieved. The medicament is used for treating symptoms such as chest stuffiness and pains and the like caused by blood stasis in chest and obstruction of the blood circulation. The total effective rate is 90.3 percent.
Description
Technical field
The present invention relates to a kind of promoting blood circulation and stopping pain medicine and preparation technology and application of treating obstruction of qi in the chest and cardialgia; Be particularly related to a kind of treatment obstruction of qi in the chest and cardialgia due to blood stasis, the hematogenous blockage in the heart; Have Chinese medicine composition and the preparation technology and the application of promoting blood circulation and stopping pain effect, belong to technical field of Chinese medicines.
Background technology
Obstruction of qi in the chest and cardialgia is meant suffocating pain over the chest a kind of disease that very then chest pain radiating to the back is losed heart, failing to sleep due to dyspnea is primary symptom.The lighter only feels uncomfortable in chest as stops up, and breathes and owes smooth; Weight person then has chest pain; Severe patient chest pain radiating to the back, backache radiating to the heart.Along with the change of modern society's life style and dietary structure, morbidity has the trend that increases gradually, thereby primary disease more and more causes people's attention.Because obstruction of qi in the chest and cardialgia shows as deficiency in origin and excess in superficiality, complicated clinical manifestation and pathological change are arranged, and Chinese medicine has the advantage of comprehensive function from integral body, thereby receive concern widely.As: name is called " a kind of Chinese medicine preparation of treating obstruction of qi in the chest and cardialgia and preparation method thereof " CN200610138675.8; Extract and Borneolum Syntheticum by the Benexate Hydrochloride of Chinese medicine Flos Caryophylli volatile oil, Chinese medicine Radix Paeoniae Rubra, Fructus Choerospondiatis, Herba Erigerontis, Semen Persicae, Flos Caryophylli are that active component etc. is formed; Has good blood circulation promoting and blood stasis dispelling; The removing obstruction in the collateral to relieve pain function, coronary heart disease is belonged to venation block pattern of syndrome person has therapeutical effect preferably.However, to treating the obstruction of qi in the chest and cardialgia due to blood stasis, the hematogenous blockage in the heart, the curative effect with Chinese medicine composition of promoting blood circulation and stopping pain effect remains further to be improved in the prior art.
Summary of the invention
Therefore, people are for the obstruction of qi in the chest and cardialgia of treating due to blood stasis, the hematogenous blockage in the heart, and still there is demand in the Chinese medicine composition with promoting blood circulation and stopping pain effect of better curative effect.Up to the present; Do not find to destroy the data of novelty of the present invention as yet; Present inventor people has collected a large amount of clinical datas through clinical practice, has obtained treating the obstruction of qi in the chest and cardialgia due to blood stasis, the hematogenous blockage in the heart; Have the Chinese medicine composition of the better curative effect of promoting blood circulation and stopping pain effect, thereby accomplished the present invention.
The object of the invention is exactly that a kind of treatment with better curative effect obstruction of qi in the chest and cardialgia due to blood stasis, the hematogenous blockage in the heart will be provided, and has Chinese medicine composition and the preparation technology and the application of promoting blood circulation and stopping pain effect.
Technical scheme one of the present invention: it is made up of following bulk drugs: 12-18 parts of Radix Angelicae Sinensis, 12-18 parts in the Radix Rehmanniae, 6-10 parts of Cortex Magnoliae Officinalis, 6-10 parts of Ramulus Cinnamomi; 8-12 parts of Rhizoma Chuanxiongs, 12-18 parts of Cortex Moutans, 8-12 parts of DAHUOXUE; 8-12 parts of Rhizoma Corydalis, 8-12 parts on Flos Carthami, 6-10 parts of Fructus Aurantii Immaturuss; 8-12 parts of Radix Paeoniae Rubra, 8-12 parts of Rhizoma Drynariae, 3-5 parts of Borneolum Syntheticums.
Preferably: it is made up of following bulk drugs: 15 parts of Radix Angelicae Sinensis, 15 parts in the Radix Rehmanniae, 8 parts of Cortex Magnoliae Officinalis, 8 parts of Ramulus Cinnamomi, 10 parts of Rhizoma Chuanxiongs, 15 parts of Cortex Moutans, 10 parts of DAHUOXUE, 10 parts of Rhizoma Corydalis, 10 parts on Flos Carthami, 8 parts of Fructus Aurantii Immaturuss, 10 parts of Radix Paeoniae Rubra, 10 parts of Rhizoma Drynariae, 4 parts of Borneolum Syntheticums.
Technical scheme two of the present invention: this preparation technology comprises the steps:
A. proportioning weighting raw materials by weight;
B. the Borneolum Syntheticum powder of getting said weight portion is broken into 120-150 purpose fine powders; Subsequent use;
C. get the medical material outside the said Borneolum Syntheticum, be ground into 20-40 purpose fine powders, the concentration that adds 6-10 times of amounts of its weight is 50-70% alcohol reflux 1-3 times; Each 1-2 hours, left standstill 12-48 hours, filter; It is 1.10-1.30 clear paste that filtrate decompression is concentrated into 40 ℃ of relative densities, and vacuum drying is ground into 120-150 purpose fine powders; Promptly get the ethanol extract fine powder, subsequent use;
D. 120-150 purpose fine powders and the ethanol extract fine powder mix homogeneously that Borneolum Syntheticum powder are broken into promptly get.
Technical scheme three of the present invention: this promoting blood circulation and stopping pain medicine has following dosage form: pill, capsule, granule, tablet, oral liquid.
Technical scheme four of the present invention: the described a kind of application of promoting blood circulation and stopping pain medicine in preparation promoting blood circulation and stopping pain medicine of treating obstruction of qi in the chest and cardialgia.
Described a kind of promoting blood circulation and stopping pain medicine of treating obstruction of qi in the chest and cardialgia is used for treating the application of the medicine of the obstruction of qi in the chest and cardialgia due to blood stasis, the hematogenous blockage in the heart in preparation.
Preparation technology is under the situation that meets " specification requirement of new Chinese medicine Study on Preparation ", and the effective constituent that mainly contains that uses modern preparation new technique to extract Chinese medicine composition is used as medicine, and adds some accessory substances; Like water, sugar, starch etc.; Also exist other method to process pill, capsule, granule; Tablet, oral liquid.
Among the present invention: Rhizoma Chuanxiong, Flos Carthami, DAHUOXUE, Cortex Moutan, Rhizoma Drynariae, Rhizoma Corydalis blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain; Radix Angelicae Sinensis, Radix Paeoniae Rubra nourshing blood and promoting blood circulation; Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Ramulus Cinnamomi circulation of qi promoting warming middle-JIAO, dispersing cold for relieving pain; Radix Rehmanniae is joined Chinese Angelica blood replonishing and blood, makes blood stasis dispelling and non-impairment of YIN blood; The Borneolum Syntheticum clearing away heat to alleviate pain.All medicines share, and play synthetic blood circulation promoting and blood stasis dispelling altogether, the merit of promoting the circulation of QI to relieve pain.Be used to treat the diseases such as obstruction of qi in the chest and cardialgia due to blood stasis, the hematogenous blockage in the heart.
The specific embodiment
The present invention can be described further through following clinical observation test and embodiment through the technical scheme practical implementation of explaining in the summary of the invention, yet scope of the present invention is not limited to following embodiment.
The clinical observation on the therapeutic effect data
1, clinical data:
1.1 physical data: this group amounts to 294 routine coronary atherosclerotic heart disease patients and is my gate and examines and inpatient wherein male 166 examples, women 128 examples; 31-50 years old 49 examples, 51-65 years old 133 example, over-65s 112 examples; The oldest 86 years old, minimum 32 years old of age.With reference to card marquis type in " disease of tcm diagnosis criterion of therapeutical effect " obstruction of qi in the chest and cardialgia is the diagnosis basis of type of obstruction of heart-blood.At random all cases are divided into two groups, 167 examples are organized in treatment, male 94 examples, women 73 examples; Matched group 127 examples, male 72 examples, women 55 examples; Through statistical procedures, the difference nonsignificance has comparability at aspects such as sex, age, the course of disease, the state of an illness for two groups of patients.When being admitted to hospital, all write down situation such as its electrocardiogram, blood pressure, heart rate, blood fat, hepatic and renal function.
1.2 Therapeutic Method: matched group gives isosorbide mononitrate; The treatment group is with blood circulation promoting and blood stasis dispelling, and promoting the circulation of QI to relieve pain are method of treatment.Prescription adjusts accordingly in following scope endogenous cause of ill symptom:
It is made up of following bulk drugs: 12-18 parts of Radix Angelicae Sinensis, 12-18 parts in the Radix Rehmanniae, 6-10 parts of Cortex Magnoliae Officinalis, 6-10 parts of Ramulus Cinnamomi; 8-12 parts of Rhizoma Chuanxiongs, 12-18 parts of Cortex Moutans, 8-12 parts of DAHUOXUE; 8-12 parts of Rhizoma Corydalis, 8-12 parts on Flos Carthami, 6-10 parts of Fructus Aurantii Immaturuss; 8-12 parts of Radix Paeoniae Rubra, 8-12 parts of Rhizoma Drynariae, 3-5 parts of Borneolum Syntheticums.Preparation technology adopts the technology in the technical scheme two of the present invention.
During treating, two groups of patients all stop using other resisting myocardial ischemias and anticoagulant, but sublingual administration nitroglycerine tablets temporarily during angina pectoris attacks, the person that has the other diseases concurrently continues to use related drugs and treats.Capsule is adorned 0.5 gram for every and is used warm water delivery service.One time 3,2 times on the one.Continuous use 1 month is checked situation such as patient's electrocardiogram, blood pressure, heart rate, blood fat, hepatic and renal function once more.
1.3 curative effect determinate standard is according to the efficacy assessment standard evaluation of obstruction of qi in the chest and cardialgia in State Administration of Traditional Chinese Medicine's " disease of tcm diagnosis criterion of therapeutical effect ".
1. cure: transference cure, electrocardiogram and relevant lab testing recover normal;
2. take a turn for the better: sx, attack times reduces, and the intermission prolongs, and lab testing has improvement;
3. do not heal: cardinal symptom and electrocardiogram do not have change.
1.4 statistical method adopts
tThe check with
ⅹ 2Check.
2, result
Two groups of patient's clinical efficacies compare, and produce effects 48 examples in 167 examples are organized in treatment, effective 103 examples, and invalid 16 examples, total effective rate is 90.3%; Produce effects 75 examples in matched group 127 examples, effective 39 examples, invalid 13 examples, total effective rate 89.8%.Through statistical analysis, treatment group and matched group on clinical efficacy relatively there was no significant difference (
P＞0.05).But shown that by check result treatment group patient is after treatment in 1 month, the clinical effectiveness that its blood stickiness and blood lipid level improve obviously is superior to matched group.
Embodiment 1: it is made up of following bulk drugs: 15 parts of Radix Angelicae Sinensis, 15 parts in the Radix Rehmanniae, 8 parts of Cortex Magnoliae Officinalis, 8 parts of Ramulus Cinnamomi, 10 parts of Rhizoma Chuanxiongs, 15 parts of Cortex Moutans, 10 parts of DAHUOXUE, 10 parts of Rhizoma Corydalis, 10 parts on Flos Carthami, 8 parts of Fructus Aurantii Immaturuss, 10 parts of Radix Paeoniae Rubra, 10 parts of Rhizoma Drynariae, 4 parts of Borneolum Syntheticums.
This preparation technology comprises the steps:
A. proportioning weighting raw materials by weight;
B. the Borneolum Syntheticum powder of getting said weight portion is broken into 120-150 purpose fine powders; Subsequent use;
C. get the medical material outside the said Borneolum Syntheticum, be ground into 20-40 purpose fine powders, the concentration that adds 6-10 times of amounts of its weight is 50-70% alcohol reflux 1-3 times; Each 1-2 hours, left standstill 12-48 hours, filter; It is 1.10-1.30 clear paste that filtrate decompression is concentrated into 40 ℃ of relative densities, and vacuum drying is ground into 120-150 purpose fine powders; Promptly get the ethanol extract fine powder, subsequent use;
D. 120-150 purpose fine powders and the ethanol extract fine powder mix homogeneously that Borneolum Syntheticum powder are broken into promptly get.
Embodiment 2: it is made up of following bulk drugs: 12 parts of Radix Angelicae Sinensis, 18 parts in the Radix Rehmanniae, 6 parts of Cortex Magnoliae Officinalis, 10 parts of Ramulus Cinnamomi, 8 parts of Rhizoma Chuanxiongs, 18 parts of Cortex Moutans, 8 parts of DAHUOXUE, 12 parts of Rhizoma Corydalis, 8 parts on Flos Carthami, 10 parts of Fructus Aurantii Immaturuss, 8 parts of Radix Paeoniae Rubra, 12 parts of Rhizoma Drynariae, 3 parts of Borneolum Syntheticums.
Preparation technology adopts the technology of embodiment 1.
Embodiment 3: it is made up of following bulk drugs: 18 parts of Radix Angelicae Sinensis, 12 parts in the Radix Rehmanniae, 10 parts of Cortex Magnoliae Officinalis, 6 parts of Ramulus Cinnamomi, 12 parts of Rhizoma Chuanxiongs, 12 parts of Cortex Moutans, 12 parts of DAHUOXUE, 8 parts of Rhizoma Corydalis, 12 parts on Flos Carthami, 6 parts of Fructus Aurantii Immaturuss, 12 parts of Radix Paeoniae Rubra, 8 parts of Rhizoma Drynariae, 5 parts of Borneolum Syntheticums.
Preparation technology adopts the technology of embodiment 1.
Embodiment 4: it is made up of following bulk drugs: 12 parts of Radix Angelicae Sinensis, 12 parts in the Radix Rehmanniae, 6 parts of Cortex Magnoliae Officinalis, 6 parts of Ramulus Cinnamomi, 8 parts of Rhizoma Chuanxiongs, 12 parts of Cortex Moutans, 8 parts of DAHUOXUE, 8 parts of Rhizoma Corydalis, 8 parts on Flos Carthami, 6 parts of Fructus Aurantii Immaturuss, 8 parts of Radix Paeoniae Rubra, 8 parts of Rhizoma Drynariae, 4 parts of Borneolum Syntheticums.
Preparation technology adopts the technology of embodiment 1.
Embodiment 5: it is made up of following bulk drugs: 18 parts of Radix Angelicae Sinensis, 18 parts in the Radix Rehmanniae, 10 parts of Cortex Magnoliae Officinalis, 10 parts of Ramulus Cinnamomi, 12 parts of Rhizoma Chuanxiongs; 18 parts of Cortex Moutans, 12 parts of DAHUOXUE, 12 parts of Rhizoma Corydalis, 12 parts on Flos Carthami; 10 parts of Fructus Aurantii Immaturuss, 12 parts of Radix Paeoniae Rubra, 12 parts of Rhizoma Drynariae, 4 parts of Borneolum Syntheticums.
Preparation technology adopts the technology of embodiment 1.
Claims (6)
1. promoting blood circulation and stopping pain medicine of treating obstruction of qi in the chest and cardialgia is characterized in that it is made up of following bulk drugs: 12-18 parts of Radix Angelicae Sinensis, 12-18 parts in the Radix Rehmanniae, 6-10 parts of Cortex Magnoliae Officinalis; 6-10 parts of Ramulus Cinnamomi, 8-12 parts of Rhizoma Chuanxiongs, 12-18 parts of Cortex Moutans, 8-12 parts of DAHUOXUE; 8-12 parts of Rhizoma Corydalis, 8-12 parts on Flos Carthami, 6-10 parts of Fructus Aurantii Immaturuss; 8-12 parts of Radix Paeoniae Rubra, 8-12 parts of Rhizoma Drynariae, 3-5 parts of Borneolum Syntheticums.
2. a kind of promoting blood circulation and stopping pain medicine of treating obstruction of qi in the chest and cardialgia according to claim 1 is characterized in that it is made up of following bulk drugs: 15 parts of Radix Angelicae Sinensis, 15 parts in the Radix Rehmanniae, 8 parts of Cortex Magnoliae Officinalis; 8 parts of Ramulus Cinnamomi, 10 parts of Rhizoma Chuanxiongs, 15 parts of Cortex Moutans, 10 parts of DAHUOXUE; 10 parts of Rhizoma Corydalis, 10 parts on Flos Carthami, 8 parts of Fructus Aurantii Immaturuss; 10 parts of Radix Paeoniae Rubra, 10 parts of Rhizoma Drynariae, 4 parts of Borneolum Syntheticums.
3. the described a kind of promoting blood circulation and stopping pain medicine of treating obstruction of qi in the chest and cardialgia of claim 1 is characterized in that this promoting blood circulation and stopping pain medicine has following dosage form: pill, capsule, granule, tablet, oral liquid.
4. the described a kind of preparation technology who treats the promoting blood circulation and stopping pain medicine of obstruction of qi in the chest and cardialgia of claim 1 is characterized in that this preparation technology comprises the steps:
A. proportioning weighting raw materials by weight;
B. the Borneolum Syntheticum powder of getting said weight portion is broken into 120-150 purpose fine powders; Subsequent use;
C. get the medical material outside the said Borneolum Syntheticum, be ground into 20-40 purpose fine powders, the concentration that adds 6-10 times of amounts of its weight is 50-70% alcohol reflux 1-3 times; Each 1-2 hours, left standstill 12-48 hours, filter; It is 1.10-1.30 clear paste that filtrate decompression is concentrated into 40 ℃ of relative densities, and vacuum drying is ground into 120-150 purpose fine powders; Promptly get the ethanol extract fine powder, subsequent use;
D. 120-150 purpose fine powders and the ethanol extract fine powder mix homogeneously that Borneolum Syntheticum powder are broken into promptly get.
5. the described a kind of application of promoting blood circulation and stopping pain medicine in preparation promoting blood circulation and stopping pain medicine of treating obstruction of qi in the chest and cardialgia of claim 1.
6. the described a kind of promoting blood circulation and stopping pain medicine of treating obstruction of qi in the chest and cardialgia of claim 1 is used for treating the application of the medicine of the obstruction of qi in the chest and cardialgia due to blood stasis, the hematogenous blockage in the heart in preparation.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547844A (en) * | 2013-10-15 | 2015-04-29 | 青岛博研达工业技术研究所(普通合伙) | Traditional Chinese medicine for treating chest stuffiness and pains with syndrome of yang deficiency and cold congelation and preparation method thereof |
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| CN104547844A (en) * | 2013-10-15 | 2015-04-29 | 青岛博研达工业技术研究所(普通合伙) | Traditional Chinese medicine for treating chest stuffiness and pains with syndrome of yang deficiency and cold congelation and preparation method thereof |
| CN104547972A (en) * | 2013-10-15 | 2015-04-29 | 青岛博研达工业技术研究所(普通合伙) | Chinese medicinal composition for treating heart and qi deficiency type chest stuffiness and pain |
| CN104547875A (en) * | 2013-10-15 | 2015-04-29 | 青岛博研达工业技术研究所(普通合伙) | Traditional Chinese medicine for treating arteries and veins stasis type chest stuffiness and pain |
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| Publication number | Publication date |
|---|---|
| CN102552520B (en) | 2014-02-12 |
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