CN102552519B - Chinese medicine composition for activating blood and stopping pain, preparation process and application - Google Patents
Chinese medicine composition for activating blood and stopping pain, preparation process and application Download PDFInfo
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- CN102552519B CN102552519B CN2011104556963A CN201110455696A CN102552519B CN 102552519 B CN102552519 B CN 102552519B CN 2011104556963 A CN2011104556963 A CN 2011104556963A CN 201110455696 A CN201110455696 A CN 201110455696A CN 102552519 B CN102552519 B CN 102552519B
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Abstract
The invention relates to a Chinese medicine composition for activating blood and stopping pain and for treating chronic lumbar strain, a preparation process and application. The Chinese medicine composition is characterized by being composed of the following raw material medicines by weight: rehmannia glutinosa 28-32 parts, caulis spatholobi 12-18 parts, angelica sinensis 8-12 parts, achyranthes bidentata 8-12 parts, liquorice 4-6 parts, longspur epimedium 8-12 parts, teasel root 12-18 parts, frankincense 4-6 parts, fructus psoraleae 8-12 parts, desert living cistanche 8-12 parts, xuanhu 8-12 parts, bark of eucommia 12-18 parts, radix pseudostellariae 18-22 parts, borneol 3-5 parts and ground beeltle 4-12 parts. The preparation process comprises taking the borneol and the ground beeltle with the parts, and respectively crushing the borneol and the ground beeltle into fine powder; performing ethanol extraction on the other medicines to obtain ethanol extract fine powder; and evenly mixing the obtained objects. A plurality of medicines are combined for use to achieve the effects of jointly nourishing and activating blood, tonifying kidneys and strengthening tendon. The Chinese medicine composition for activating the blood and stopping the pain, the preparation process and the application are used for treating diseases of chronic lumbar strain and the like caused by kidney and liver insufficiency and qi and blood weakness. The total effective rate is 97.1%.
Description
Technical field
The present invention relates to a kind of traditional Chinese medicinal composition for blood circulation invigorating and preparation technology and application, particularly a kind of lumbar muscle strain for the treatment of has Chinese medicine composition and preparation technology and the application of promoting blood circulation and stopping pain effect, belongs to technical field of Chinese medicines.
Background technology
Lumbar muscle strain is a kind of common waist disease, refers to that the disease of pain occurs for waist one or both sides or just medium place, is found in the diseases such as nephropathy that modern medicine is referred to as, rheumatism, rheumatoid disease, lumbar muscle strain vertebra and wound, gynecological.Cardinal symptom is waist or waist and sacrum pain, outbreak repeatedly, and pain can change with climate change or tired degree.The traditional Chinese medical science can think that lumbar muscle strain is because experiencing due to cold-damp, damp and hot, qi depression to blood stasis, deficiency of the kidney body void or tumbling down wound.Prior art as: the name be called " a kind of Chinese medicine composition for the treatment of lumbar muscle degeneration by oral administration " CN200710014232.2, the crude drug of its effective ingredient by following weight portion is: the Radix Astragali, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Gentianae Macrophyllae, Rhizoma Chuanxiong etc.Its drug effect has synergism, and the Chinese medicine composition of this kind treating lumbar muscle degeneration by oral administration has been obtained remarkable result in the therapeutic process of lumbar muscle strain.However, in prior art, to the treatment lumbar muscle strain, the curative effect with Chinese medicine composition of promoting blood circulation and stopping pain effect remains further to be improved.
Summary of the invention
Therefore, people are for the treatment lumbar muscle strain, and still there is demand in the Chinese medicine composition with promoting blood circulation and stopping pain effect of better curative effect.Up to the present, not yet find to destroy the data of novelty of the present invention, present inventor people is by clinical practice, a large amount of clinical datas have been collected, obtained the treatment lumbar muscle strain, had the Chinese medicine composition of the better curative effect of promoting blood circulation and stopping pain effect, thereby completed the present invention.
Purpose of the present invention is exactly that a kind for the treatment of lumbar muscle strain with better curative effect will be provided, and has Chinese medicine composition and preparation technology and the application of promoting blood circulation and stopping pain effect.
Technical solution of the present invention one: it is comprised of the crude drug of following weight portion: 28-32 parts, Radix Rehmanniae Preparata, 12-18 parts of Caulis Spatholobis, 8-12 parts of Radix Angelicae Sinensis, 8-12 parts of Huaihe River cattle sunset, 4-6 parts, Radix Glycyrrhizae, 8-12 parts of Herba Epimedii, 12-18 parts of Radix Dipsacis, 4-6 parts of Olibanum (processed)s, 8-12 parts of Fructus Psoraleaes, 8-12 parts of Herba Cistanches, 8-12 parts of Rhizoma Corydalis, 12-18 parts of the Cortexs Eucommiae, 18-22 parts of Radix Pseudostellariaes, 3-5 parts of Borneolum Syntheticums, 4-12 parts of Eupolyphaga Seu Steleophagas.
Preferably: it is comprised of the crude drug of following weight portion: 30 parts, Radix Rehmanniae Preparata, 15 parts of Caulis Spatholobis, 10 parts of Radix Angelicae Sinensis, 10 parts of Huaihe River cattle sunset, 5 parts, Radix Glycyrrhizae, 10 parts of Herba Epimedii, 15 parts of Radix Dipsacis, 5 parts of Olibanum (processed)s, 10 parts of Fructus Psoraleaes, 10 parts of Herba Cistanches, 10 parts of Rhizoma Corydalis, 15 parts of the Cortexs Eucommiae, 20 parts of Radix Pseudostellariaes, 4 parts of Borneolum Syntheticums, 6 parts of Eupolyphaga Seu Steleophagas.
Technical solution of the present invention two: this preparation technology comprises the steps:
A. proportioning weighting raw materials by weight;
B. Borneolum Syntheticum and the Eupolyphaga Seu Steleophaga of getting described weight portion are ground into respectively 120-150 purpose fine powders; Standby;
C. get the medical material outside described Borneolum Syntheticum and Eupolyphaga Seu Steleophaga, pulverizing medicinal materials becomes 20-40 purpose fine powders, the concentration that adds 6-10 times of amounts of its weight is 50-70% alcohol reflux 1-3 times, each 1-2 hours, and standing 12-48 hours, filter, it is 1.10-1.30 clear paste that filtrate decompression is concentrated into 40 ℃ of relative densities, and vacuum drying is ground into 120-150 purpose fine powders, namely get the ethanol extract fine powder, standby;
D, 120-150 purpose fine powders that Borneolum Syntheticum and Eupolyphaga Seu Steleophaga are ground into respectively, and ethanol extract fine powder mix homogeneously, and get final product.
Technical solution of the present invention three: described a kind of traditional Chinese medicinal composition for blood circulation invigorating for the treatment of chronic lumbar muscle strain has following dosage form: pill, capsule, granule, tablet, oral liquid.
Technical solution of the present invention four: the described a kind of application of traditional Chinese medicinal composition for blood circulation invigorating in preparation promoting blood circulation and stopping pain medicine for the treatment of chronic lumbar muscle strain.
Described a kind of traditional Chinese medicinal composition for blood circulation invigorating for the treatment of chronic lumbar muscle strain is for the preparation of the treatment caused by liver and kidney deficiency, the application due to deficient qi and blood in the medicine of chronic lumbar muscle strain.
Preparation technology is in the situation that meet " specification requirement of new Chinese medicine Study on Preparation ", the effective constituent that mainly contains that uses modern new agent technology to extract Chinese medicine composition is used as medicine, add some accessory substances, as water, sugar, starch etc., also exist other method to make pill, capsule, granule, tablet, oral liquid.
In the present invention: Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Caulis Spatholobi nourshing blood and promoting blood circulation, moisten flourish muscle arteries and veins; Olibanum, Huaihe River Niu Xi, Rhizoma Corydalis promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain; Herba Epimedii, Herba Cistanches, Fructus Psoraleae, Radix Dipsaci, the Cortex Eucommiae, Eupolyphaga Seu Steleophaga warming and recuperating the kidney-YANG, strengthening the tendons and bones; The Borneolum Syntheticum clearing away heat to alleviate pain; Be equipped with Radix Pseudostellariae QI invigorating benefit; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Close and use it, playing altogether nourshing blood and promoting blood circulation, the effect of the strong muscle of the kidney invigorating.Be used for the treatment of caused by liver and kidney deficiency, the disease such as chronic lumbar muscle strain due to deficient qi and blood.
The specific embodiment
The present invention can specifically implement by the technical scheme that illustrates in summary of the invention, be described further by following clinical observation test and embodiment, yet scope of the present invention is not limited to following embodiment.
The clinical observation on the therapeutic effect data
1, clinical data:
1.1 physical data: this group amounts to 258 routine chronic lumbar muscle strain patients and is my Out-patient Department and inpatient, male 143 examples wherein, female's 115 examples; 31-50 years old 44 examples, 51-65 years old 118 example, over-65s 96 examples; The oldest 91 years old, minimum 36 years old of age.Be the diagnosis basis of renal deficiency type with reference to card marquis type in " disease of tcm Standardization of diagnosis and curative effect " lumbar muscle strain.At random all cases are divided into two groups, treatment group 137 examples, male 74 examples, female's 63 examples; Matched group 121 examples, male 69 examples, female's 52 examples; Two groups of patients learn processing by statistics at aspects such as sex, age, the course of disease, the state of an illness, and the difference nonsignificance has comparability.
1.2 Therapeutic Method: matched group gives the etidocine tablet treatment; Treatment group is with nourshing blood and promoting blood circulation, and the strong muscle of the kidney invigorating is method for the treatment of.Two weeks of taking medicine are 1 course for the treatment of.Prescription adjusts accordingly in following scope endogenous cause of ill symptom:
It is comprised of the crude drug of following weight portion: 28-32 parts, Radix Rehmanniae Preparata, 12-18 parts of Caulis Spatholobis, 8-12 parts of Radix Angelicae Sinensis, 8-12 parts of Huaihe River cattle sunset, 4-6 parts, Radix Glycyrrhizae, 8-12 parts of Herba Epimedii, 12-18 parts of Radix Dipsacis, 4-6 parts of Olibanum (processed)s, 8-12 parts of Fructus Psoraleaes, 8-12 parts of Herba Cistanches, 8-12 parts of Rhizoma Corydalis, 12-18 parts of the Cortexs Eucommiae, 18-22 parts of Radix Pseudostellariaes, 3-5 parts of Borneolum Syntheticums, 4-12 parts of Eupolyphaga Seu Steleophagas.
Capsule, every fills 0.5 gram with warm yellow wine or warm water delivery service.One time 3,2 times on the one.Continuous use 1 month.During treating, encourage two groups of patients to carry out suitable functional exercise etc.
1.3 curative effect determinate standard is according to the efficacy assessment standard evaluation of lumbar muscle strain in State Administration of Traditional Chinese Medicine's " disease of tcm Standardization of diagnosis and curative effect ".
1. cure: the lumbago transference cure, the waist activity is freely;
2. take a turn for the better: lumbago alleviates, and the waist movable function recovers substantially;
3. do not heal: symptom is not improved.
1.4 statistical method adopts
tThe check and
ⅹ 2Check.
2, result
Two groups of patient clinical curative effects compare, produce effects 44 examples in treatment group 137 examples, and effective 89 examples, invalid 4 examples, total effective rate is 97.1%; Produce effects 12 examples in matched group 121 examples, effective 81 examples, invalid 28 examples, total effective rate 76.9%.Epidemiological Analysis by statistics, treatment group and matched group exist on clinical efficacy extremely significant difference (
P＜0.05).
Embodiment 1: it is comprised of the crude drug of following weight portion: 30 parts, Radix Rehmanniae Preparata, 15 parts of Caulis Spatholobis, 10 parts of Radix Angelicae Sinensis, 10 parts of Huaihe River cattle sunset, 5 parts, Radix Glycyrrhizae, 10 parts of Herba Epimedii, 15 parts of Radix Dipsacis, 5 parts of Olibanum (processed)s, 10 parts of Fructus Psoraleaes, 10 parts of Herba Cistanches, 10 parts of Rhizoma Corydalis, 15 parts of the Cortexs Eucommiae, 20 parts of Radix Pseudostellariaes, 4 parts of Borneolum Syntheticums, 6 parts of Eupolyphaga Seu Steleophagas.
This preparation technology comprises the steps:
A. proportioning weighting raw materials by weight;
B. Borneolum Syntheticum and the Eupolyphaga Seu Steleophaga of getting described weight portion are ground into respectively 120-150 purpose fine powders; Standby;
C. get the medical material outside described Borneolum Syntheticum and Eupolyphaga Seu Steleophaga, pulverizing medicinal materials becomes 20-40 purpose fine powders, the concentration that adds 6-10 times of amounts of its weight is 50-70% alcohol reflux 1-3 times, each 1-2 hours, and standing 12-48 hours, filter, it is 1.10-1.30 clear paste that filtrate decompression is concentrated into 40 ℃ of relative densities, and vacuum drying is ground into 120-150 purpose fine powders, namely get the ethanol extract fine powder, standby;
D, 120-150 purpose fine powders that Borneolum Syntheticum and Eupolyphaga Seu Steleophaga are ground into respectively, and ethanol extract fine powder mix homogeneously, and get final product.
Embodiment 2: it is comprised of the crude drug of following weight portion: 28 parts, Radix Rehmanniae Preparata, 12 parts of Caulis Spatholobis, 8 parts of Radix Angelicae Sinensis, 8 parts of Huaihe River cattle sunset, 4 parts, Radix Glycyrrhizae, 8 parts of Herba Epimedii, 12 parts of Radix Dipsacis, 4 parts of Olibanum (processed)s, 8 parts of Fructus Psoraleaes, 8 parts of Herba Cistanches, 8 parts of Rhizoma Corydalis, 12 parts of the Cortexs Eucommiae, 18 parts of Radix Pseudostellariaes, 3 parts of Borneolum Syntheticums, 12 parts of Eupolyphaga Seu Steleophagas.
Preparation technology adopts the technique in technical solution of the present invention two.
Embodiment 3: it is comprised of the crude drug of following weight portion: 32 parts, Radix Rehmanniae Preparata, 18 parts of Caulis Spatholobis, 12 parts of Radix Angelicae Sinensis, 12 parts of Huaihe River cattle sunset, 6 parts, Radix Glycyrrhizae, 12 parts of Herba Epimedii, 18 parts of Radix Dipsacis, 6 parts of Olibanum (processed)s, 12 parts of Fructus Psoraleaes, 12 parts of Herba Cistanches, 12 parts of Rhizoma Corydalis, 18 parts of the Cortexs Eucommiae, 22 parts of Radix Pseudostellariaes, 5 parts of Borneolum Syntheticums, 4 parts of Eupolyphaga Seu Steleophagas.
Preparation technology adopts the technique in technical solution of the present invention two.
Embodiment 4: it is comprised of the crude drug of following weight portion: 28 parts, Radix Rehmanniae Preparata, 18 parts of Caulis Spatholobis, 8 parts of Radix Angelicae Sinensis, 12 parts of Huaihe River cattle sunset, 4 parts, Radix Glycyrrhizae, 12 parts of Herba Epimedii, 12 parts of Radix Dipsacis, 6 parts of Olibanum (processed)s, 8 parts of Fructus Psoraleaes, 12 parts of Herba Cistanches, 8 parts of Rhizoma Corydalis, 18 parts of the Cortexs Eucommiae, 18 parts of Radix Pseudostellariaes, 4 parts of Borneolum Syntheticums, 6 parts of Eupolyphaga Seu Steleophagas.
Preparation technology adopts the technique in technical solution of the present invention two.
Embodiment 5: it is comprised of the crude drug of following weight portion: 32 parts, Radix Rehmanniae Preparata, 12 parts of Caulis Spatholobis, 12 parts of Radix Angelicae Sinensis, 8 parts of Huaihe River cattle sunset, 6 parts, Radix Glycyrrhizae, 8 parts of Herba Epimedii, 18 parts of Radix Dipsacis, 4 parts of Olibanum (processed)s, 12 parts of Fructus Psoraleaes, 8 parts of Herba Cistanches, 12 parts of Rhizoma Corydalis, 12 parts of the Cortexs Eucommiae, 22 parts of Radix Pseudostellariaes, 5 parts of Borneolum Syntheticums, 10 parts of Eupolyphaga Seu Steleophagas.
Preparation technology adopts the technique in technical solution of the present invention two.
Claims (2)
1. a traditional Chinese medicinal composition for blood circulation invigorating preparation technology who treats chronic lumbar muscle strain, is characterized in that this preparation technology comprises the steps:
A. proportioning weighting raw materials by weight; 28-32 parts, Radix Rehmanniae Preparata, 12-18 parts of Caulis Spatholobis, 8-12 parts of Radix Angelicae Sinensis, 8-12 parts of Huaihe River cattle sunset, 4-6 parts, Radix Glycyrrhizae, 8-12 parts of Herba Epimedii, 12-18 parts of Radix Dipsacis, 4-6 parts of Olibanum (processed)s, 8-12 parts of Fructus Psoraleaes, 8-12 parts of Herba Cistanches, 8-12 parts of Rhizoma Corydalis, 12-18 parts of the Cortexs Eucommiae, 18-22 parts of Radix Pseudostellariaes, 3-5 parts of Borneolum Syntheticums, 4-12 parts of Eupolyphaga Seu Steleophagas;
B. Borneolum Syntheticum and the Eupolyphaga Seu Steleophaga of getting described weight portion are ground into respectively 120-150 purpose fine powders; Standby;
C. get the medical material outside described Borneolum Syntheticum and Eupolyphaga Seu Steleophaga, pulverizing medicinal materials becomes 20-40 purpose fine powders, the concentration that adds 6-10 times of amounts of its weight is 50-70% alcohol reflux 1-3 times, each 1-2 hours, and standing 12-48 hours, filter, it is 1.10-1.30 clear paste that filtrate decompression is concentrated into 40 ℃ of relative densities, and vacuum drying is ground into 120-150 purpose fine powders, namely get the ethanol extract fine powder, standby;
D, 120-150 purpose fine powders that Borneolum Syntheticum and Eupolyphaga Seu Steleophaga are ground into respectively, and ethanol extract fine powder mix homogeneously, and get final product.
2. a kind of traditional Chinese medicinal composition for blood circulation invigorating preparation technology who treats chronic lumbar muscle strain according to claim 1, is characterized in that this traditional Chinese medicinal composition for blood circulation invigorating has following dosage form: pill, capsule, granule, tablet.
3. a kind of application of traditional Chinese medicinal composition for blood circulation invigorating in preparation promoting blood circulation and stopping pain medicine for the treatment of the traditional Chinese medicinal composition for blood circulation invigorating preparation technology preparation of chronic lumbar muscle strain according to claim 1.
4. the traditional Chinese medicinal composition for blood circulation invigorating of a kind of traditional Chinese medicinal composition for blood circulation invigorating preparation technology preparation for the treatment of chronic lumbar muscle strain according to claim 1 is for the preparation of the treatment caused by liver and kidney deficiency, the application due to deficient qi and blood in the medicine of chronic lumbar muscle strain.
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| CN104606455B (en) * | 2015-02-13 | 2015-09-16 | 祝爱莲 | A kind of medicament for the treatment of lumbar muscle strain |
| CN111067979A (en) * | 2018-10-22 | 2020-04-28 | 广西小咕噜生物科技有限公司 | External traditional Chinese medicine formula for treating shoulder, neck and lumbago |
| CN111773264A (en) * | 2020-08-17 | 2020-10-16 | 张博 | A pharmaceutical composition for treating nephropathy, and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101279079A (en) * | 2008-04-10 | 2008-10-08 | 北京中泰天和科技有限公司 | Chinese medicine composite for nourishing kidney, removing dampness and strengthening muscle, and relaxing tendons and collaterals |
| CN101574432A (en) * | 2009-04-07 | 2009-11-11 | 北京万寿通医药科技有限公司 | Traditional Chinese medicine preparation for curing lumbar muscle strain |
| KR101011285B1 (en) * | 2010-04-23 | 2011-01-28 | 변경삼 | Composition for relieving pain of lumber intervertebral disc and preparation method thereof |
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| CN1063945C (en) * | 1995-09-25 | 2001-04-04 | 石建民 | External compress paste for discopathy |
| CN101637557A (en) * | 2008-07-28 | 2010-02-03 | 杜焕印 | Liquid medicine for promoting blood circulation and dispelling pain |
| CN102166277B (en) * | 2011-03-31 | 2013-10-30 | 谢子俊 | Waist healing pill |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101279079A (en) * | 2008-04-10 | 2008-10-08 | 北京中泰天和科技有限公司 | Chinese medicine composite for nourishing kidney, removing dampness and strengthening muscle, and relaxing tendons and collaterals |
| CN101574432A (en) * | 2009-04-07 | 2009-11-11 | 北京万寿通医药科技有限公司 | Traditional Chinese medicine preparation for curing lumbar muscle strain |
| KR101011285B1 (en) * | 2010-04-23 | 2011-01-28 | 변경삼 | Composition for relieving pain of lumber intervertebral disc and preparation method thereof |
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